LOCUS       CP088355               23266 bp    DNA     circular BCT 09-DEC-2021
DEFINITION  Escherichia coli strain F17EC0147 plasmid pF17EC0147-3, complete
            sequence.
ACCESSION   CP088355
VERSION     CP088355.1
DBLINK      BioProject: PRJNA782071
            BioSample: SAMN23391704
KEYWORDS    .
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1  (bases 1 to 23266)
  AUTHORS   Yoon,E.-J., Choi,Y.J., Kim,D., Won,D., Choi,J.R. and Jeong,S.H.
  TITLE     Chromosomal integration and amplification of group 9 blaCTX-M genes
            in Escherichia coli expand the spectrum of resistance under
            antimicrobial pressure
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 23266)
  AUTHORS   Yoon,E.-J., Choi,Y.J., Kim,D., Won,D., Choi,J.R. and Jeong,S.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-NOV-2021) Research Institute of Bacterial Resistance,
            Yonsei University College of Medicine, Gangnam Severance Hospital,
            Yonsei, Seoul 06273, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: other: SMRTLink v. v9.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 88x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 12/02/2021 11:36:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 5.3
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 5,345
            CDSs (total)                      :: 5,231
            Genes (coding)                    :: 4,973
            CDSs (with protein)               :: 4,973
            Genes (RNA)                       :: 114
            rRNAs                             :: 8, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 87
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 258
            CDSs (without protein)            :: 258
            Pseudo Genes (ambiguous residues) :: 0 of 258
            Pseudo Genes (frameshifted)       :: 109 of 258
            Pseudo Genes (incomplete)         :: 190 of 258
            Pseudo Genes (internal stop)      :: 40 of 258
            Pseudo Genes (multiple problems)  :: 71 of 258
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..23266
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /strain="F17EC0147"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:562"
                     /plasmid="pF17EC0147-3"
                     /geo_loc_name="South Korea"
                     /lat_lon="35.18 N 129.08 E"
                     /collection_date="2017"
                     /collected_by="Kor-GLASS"
     gene            complement(join(22936..23266,1..8))
                     /locus_tag="LQT59_26605"
                     /pseudo=""
     CDS             complement(join(22936..23266,1..8))
                     /locus_tag="LQT59_26605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004102821.1"
                     /note="frameshifted; incomplete; partial on complete
                     genome; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S-containing protein"
                     /name="Fe-S-containing protein"
     gene            72..851
                     /locus_tag="LQT59_26610"
                     /pseudo=""
     CDS             72..851
                     /locus_tag="LQT59_26610"
                     /inference="COORDINATES: protein motif:HMM:NF024733.2"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            complement(1755..2139)
                     /locus_tag="LQT59_26615"
                     /pseudo=""
     CDS             complement(1755..2139)
                     /locus_tag="LQT59_26615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_708754.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-ribbon domain-containing protein"
                     /name="zinc-ribbon domain-containing protein"
     gene            complement(2228..2707)
                     /locus_tag="LQT59_26620"
                     /pseudo=""
     CDS             complement(2228..2707)
                     /locus_tag="LQT59_26620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612086.1"
                     /note="frameshifted; incomplete; partial on complete
                     genome; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /name="IS3 family transposase"
     gene            complement(2791..4304)
                     /gene="ltrA"
                     /locus_tag="LQT59_26625"
                     /pseudo=""
     CDS             complement(2791..4304)
                     /gene="ltrA"
                     /locus_tag="LQT59_26625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_708749.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron reverse transcriptase/maturase"
                     /name="ltrA"
     gene            complement(4977..5717)
                     /locus_tag="LQT59_26630"
                     /pseudo=""
     CDS             complement(4977..5717)
                     /locus_tag="LQT59_26630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612086.1"
                     /note="frameshifted; incomplete; partial on complete
                     genome; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /name="IS3 family transposase"
     misc_feature    complement(5320..5436)
                     /locus_tag="LQT59_26630"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF01497"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="AL1L pseudoknot; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /pseudo=""
                     /db_xref="RFAM:RF01497"
     gene            5769..6047
                     /locus_tag="LQT59_26635"
                     /pseudo=""
     CDS             5769..6047
                     /locus_tag="LQT59_26635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000198547.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS91 family transposase"
                     /name="IS91 family transposase"
     gene            complement(6570..7747)
                     /gene="senB"
                     /locus_tag="LQT59_26640"
                     /pseudo=""
     CDS             complement(6570..7747)
                     /gene="senB"
                     /locus_tag="LQT59_26640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001020413.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="enterotoxin production-related protein TieB"
                     /name="senB"
     gene            complement(7816..10077)
                     /locus_tag="LQT59_26645"
     CDS             complement(7816..10077)
                     /locus_tag="LQT59_26645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001100765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TonB-dependent receptor"
                     /protein_id="UGD32853.1"
                     /translation="MNVIKLAIGSGILLLSCGAYSQSISEKTNSDKKGAAEFSPLSVSV
                     GKTTSEQEALEKTGATSSRTTDKNLQSLDATVRSMPGTYTQIDPGQGAISVNIRGMSGF
                     GRVNTMVDGITQSFYGTSTSGTTTHGSTNNMAGVLIDPNLLVAVDVTRGDSSGSEGINA
                     LAGSANMRTIGVDDVIFNGNTYGLRSRFSVGSNGLGRSGMIALGGKSDAFTDTGSIGVM
                     AAVSGSSVYSNFSNGSGINSKEFGYDKYMKQNPKSQLYKMDIRPDEFNSFELSARTYEN
                     KFTRRDITSDDYYIKYHYTPFSELIDFNVTASTSRGNQKYRDGSLYTFYKTSAQNRSDA
                     LDINNTSRFTVADNDLEFMLGSKLMRTRYDRTIHSAAGDPKANQESIENNPFAPSGQQD
                     ISALYTGLKVTRGIWEADFNLNYTRNRITGYKPACDSRVICVPQGSYDIDDKEGGFNPS
                     VQLSAQVTPWLQPFIGYSKSMRAPNIQEMFFSNSGGASMNPFLKPERAETWQAGFNIDT
                     RDLLVEQDALRFKALAYRSRIQNYIYSESYLVCSGGRKCSLPEVIGNGWEGISDEYSDN
                     MYIYVNSASDVIAKGFELEMDYDAGFAFGRLSFSQQQTDQPTSIASTHFGAGDITELPR
                     KYMTLDTGVRFFDNALTLGTIIKYTGKARRLSPDFEQDEHTGAIIKQDLPQIPTIIDLY
                     GTYEYNRNLTLKLSVQNLMNRDYSEALNKLNMMPGLGDETHPANSARGRTWIFGGDIRF
                     "
                     /name="TonB-dependent receptor"
     gene            complement(10246..11025)
                     /locus_tag="LQT59_26650"
     CDS             complement(10246..11025)
                     /locus_tag="LQT59_26650"
                     /inference="COORDINATES: protein motif:HMM:TIGR01352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy transducer TonB"
                     /protein_id="UGD32854.1"
                     /translation="MDDEYSPLLTVGKMEQLVYLFSTASWTDFPCVYLAFFRSSARYVS
                     CTGDHAAMGRNYRGSFFSTFASGGNRSTGVRSEEEKQQTEDRQQRPVTEDSDATIEITR
                     KKKSSDGEKKKTRPPRKIKAQTSDSNPTAVSSNAAPQALVESSRIAAPFNSDSTKRDNS
                     EASWESRVKGHLNRYKRYPGDARKRARTGTAVVTFTVNTEGTIVSSFLEISSGTFSLDR
                     EAIAVLERAQPLPKPPPEILEGGLFKVKMPITFKLKE"
                     /name="energy transducer TonB"
     gene            complement(11029..11904)
                     /locus_tag="LQT59_26655"
     CDS             complement(11029..11904)
                     /locus_tag="LQT59_26655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001224622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ChaN family lipoprotein"
                     /protein_id="UGD32855.1"
                     /translation="MRKFILISMITLASVSLGACRQNVTIKQDAPGQKAFLTDGQIYDL
                     HSGKIISSSELLADLATAQHLIIGEKHDNAEHHQIELWLIQNLLIQRPQGSVLLEMLTS
                     EQQPRVNQVKCWLKDNPVVRDSRVQELLNWQKGWSWEMYGDIVMQLLRGPYPLLNANIG
                     REQILALYKKNEFPKGKKSTAPVVQEALRETIISMHEGNLESQQLTSMLSIQQQRDRYM
                     ARQLLSAPVPSLLIAGGYHASKSMGVPLHMEDLATGTHPVVLMLAEKGMNITVDHADYV
                     WFVAPDTTKR"
                     /name="ChaN family lipoprotein"
     gene            complement(12277..12902)
                     /locus_tag="LQT59_26660"
                     /pseudo=""
     CDS             complement(12277..12902)
                     /locus_tag="LQT59_26660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005221104.1"
                     /note="frameshifted; incomplete; partial on complete
                     genome; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /name="replication initiation protein"
     gene            complement(14354..14689)
                     /locus_tag="LQT59_26665"
     CDS             complement(14354..14689)
                     /locus_tag="LQT59_26665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001080726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin E1 immunity protein"
                     /protein_id="UGD32847.1"
                     /translation="MNRKYYFNNMWWGWVTGGYMLYMSWDYDFKYRLLFWCISLCGMVL
                     YPVAKWYIEDTALKFTRPDFWNSGFFTDTPGKMGLLAVYTGTVFILSLPLSMIYILSVI
                     IKRLSVR"
                     /name="colicin E1 immunity protein"
     gene            14818..15165
                     /locus_tag="LQT59_26670"
     CDS             14818..15165
                     /locus_tag="LQT59_26670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001563283.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF6404 family protein"
                     /protein_id="UGD32848.1"
                     /translation="MTFEQKKARAIALMDSKKMWRSNYAPPLLRILWRLGIRLPPLPFM
                     PFWQVTVLTGGLWGISWGCAMWFIYWGPSGMVAGEAIIISITGGFLSGLLMASFHWWRR
                     KVNRLPPWDDV"
                     /name="DUF6404 family protein"
     gene            complement(15185..15694)
                     /locus_tag="LQT59_26675"
     CDS             complement(15185..15694)
                     /locus_tag="LQT59_26675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001545742.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UGD32849.1"
                     /translation="MTQSRRPSPLQRRVLIVLAALDEKRPGPVLTRDIERVLEQSGEAP
                     VYGPNLRASCRRLEDAGWLRTLRAPNLQLAVELTDAGRAVAQPLLPAGGTSATDLAVEL
                     NGITYQACRGDFVVRLDGSTCLQLWNKEGRVVRREGDPLEVAQWLQACHDAGMEVRVQI
                     NESAAP"
                     /name="hypothetical protein"
     gene            complement(15691..15951)
                     /locus_tag="LQT59_26680"
     CDS             complement(15691..15951)
                     /locus_tag="LQT59_26680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001523449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UGD32850.1"
                     /translation="MDQEMTFSLSYEQLTRFAEKRIRECNLDSHGVTYLCESAKAGAVL
                     IFWHELAINGYTSMNAIKRQEIIDADHQRLRKLIWPEDDWK"
                     /name="hypothetical protein"
     gene            16053..16792
                     /locus_tag="LQT59_26685"
                     /pseudo=""
     CDS             16053..16792
                     /locus_tag="LQT59_26685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612086.1"
                     /note="frameshifted; incomplete; partial on complete
                     genome; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /name="IS3 family transposase"
     misc_feature    16334..16450
                     /locus_tag="LQT59_26685"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF01497"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="AL1L pseudoknot; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /pseudo=""
                     /db_xref="RFAM:RF01497"
     gene            17464..17760
                     /locus_tag="LQT59_26690"
                     /pseudo=""
     CDS             17464..17760
                     /locus_tag="LQT59_26690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_708749.1"
                     /note="incomplete; partial on complete genome; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            17778..17950
                     /locus_tag="LQT59_26695"
                     /pseudo=""
     CDS             17778..17950
                     /locus_tag="LQT59_26695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012218039.1"
                     /note="frameshifted; incomplete; partial on complete
                     genome; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /name="transposase"
     gene            complement(18100..18734)
                     /locus_tag="LQT59_26700"
                     /pseudo=""
     CDS             complement(18100..18734)
                     /locus_tag="LQT59_26700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_309185.1"
                     /note="frameshifted; incomplete; partial on complete
                     genome; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="histidine-type phosphatase"
                     /name="histidine-type phosphatase"
     gene            complement(19022..19366)
                     /locus_tag="LQT59_26705"
     CDS             complement(19022..19366)
                     /locus_tag="LQT59_26705"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UGD32851.1"
                     /translation="MNDAYGEIPNGIYLERRKPCDSAGNAGILTTEQIAQLLHTNITAV
                     RNMAYRLKLSLRVTAYNHRRIAQVQALYASETLSLKEIAAKTGLTASTVQYIVYVKSKI
                     SPTPPRNMSL"
                     /name="hypothetical protein"
     gene            complement(19363..19848)
                     /locus_tag="LQT59_26710"
     CDS             complement(19363..19848)
                     /locus_tag="LQT59_26710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005122129.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TlpA family protein disulfide reductase"
                     /protein_id="UGD32852.1"
                     /translation="MRWHNVLLLAAAILISGCKEEKLAVGAPAPALAAFDLQGQESGLE
                     RWQGKAVYLNFWSAGCGGCLAEMDTLEALSKKWGDKVVVVAVNTDPETVRINDLLAKHQ
                     ITYPVVRDQLNITQERYQVIGTPTSVLIDSEGRVLELHQGMRKPSELEATFARLAAR"
                     /name="TlpA family protein disulfide reductase"
     gene            complement(19835..20529)
                     /locus_tag="LQT59_26715"
                     /pseudo=""
     CDS             complement(19835..20529)
                     /locus_tag="LQT59_26715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004863043.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /name="ABC transporter ATP-binding protein"
     gene            complement(20534..21663)
                     /locus_tag="LQT59_26720"
                     /pseudo=""
     CDS             complement(20534..21663)
                     /locus_tag="LQT59_26720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000729219.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /name="ABC transporter permease"
     gene            complement(21653..22933)
                     /locus_tag="LQT59_26725"
                     /pseudo=""
     CDS             complement(21653..22933)
                     /locus_tag="LQT59_26725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011906231.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /name="ABC transporter permease"
     Typing          complement(12237..12782)
                     /name="rep_cluster_2131"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="91.887"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 ccgtgaccag tggatcgatg tgctgctgcg ctcggtgggt atggagcccg ccaatattga
       61 gcaacgcacc aatggcacct tatcacccgt atgatcccgt tcgtggagac aactataacg
      121 tttgcgagct ggggccgcgt ggcacaggta aaagccatgt gtataaagag tgttctccta
      181 actccctgtt tagtttccgg cgggcaaacg accgttgcca acttgtttct acaacatggc
      241 cagttcgcca gatcggcctg gttggcatgt gggatgtggt agcgttcgac gaagtcgcgg
      301 ggatcacttt caaagataaa gacggcgtgc aaatcatgaa agattacatg gcgtcaggat
      361 ctttctctcg cggcagagat tcgattgaag gtaaagcgtc gatggttttc gtcggcaaca
      421 tcaatcaaag cgtagagact ctcgttaaaa accagccaat ttgctggcgc catttcggct
      481 gcgatgattg atactgcatt ttttcgaccg ctttcatgcc tatattcccg gttgggaaat
      541 ccccaaaatg cgcccggaat tatttaccaa ccgttacggg ctgattacgg attatctcgc
      601 tgaatatatg cgcgaaatgc gcaaacgcag tttctctgat gcgattgata aattctttta
      661 agctggtaac aacctcaacc acgtgacgta ttgccgttcg acgtaccgtg tcggggttgt
      721 taaaactcat gcatccgatg gcgcgtacag caaaggaaga tgtgcgagtc tgcctgacct
      781 atgcgatgga agttcgccgc cgcgtgaaag agcaacttaa aaactgggcg gtctggagtt
      841 cttcgatgtg aactttagct acatgcgata acgaaacgct ggaagagttt tttgtaagcg
      901 taccggaaca gggcgcagca gaacttattc ctgccggaat gccaaagccg ggtgttgtgc
      961 atctggtcac tcaggcagaa agcggcatga ccgggctgtt atcgttttga aacacagatg
     1021 actgccggta atgtaagcat agtgtatcgg gtctgggttc aaatacctcc gcgaaagaag
     1081 ctatccgcgt cggtttcgat tacttcaaag gcaatttgaa tcgggtaagc gcggccgcga
     1141 aattctccga tcatgaatac accttcatgt cgttgaactg cataatactg gcccaagcac
     1201 cgcaaccagt cttgctgcgc ttatcgcttt atgttcgata ttgttggcaa aaccgtgcag
     1261 gaacagatgg tggtgttggg cagtatgacg cttggtgggg taattaaccg gtgcaggatc
     1321 ttgccgccag tttgcagctc gccttcgaca gcggtgcaaa acgggttctg ttgccgatgt
     1381 cctcggctat ggatattcca acggttccgg cagcgtttat taccaagttt caggtgagtt
     1441 tttactcaga ccccggttga tgctgtttat aaggcgctgg gtgtgaatta acgtagtaac
     1501 tattttaatg aactggagga caatggctca agaacgttct gtaattaaat tcatcagacc
     1561 ttgcctctcc attcatgaat ataaaaatac ttacatctga gtatttgttg gctgtgtttg
     1621 aataaaaaga gagctgttca aataagcctg tataactgtt cttttcaaaa aatggaggag
     1681 ctatcagcta attcaacact ggaagatgtt cgtcgagttg gattgaacgc cctgcgcaga
     1741 ccaggcattt cggattaagt gttcgcactt ccacagtcct ggaacaagtc tggctggtag
     1801 ctgtaaacat actttgtaca taccgctctg gaatagaatc cccgtgccac aggcttcaca
     1861 gaactttttc ccgggaaaat gctgcccgca catcacacaa tgccactcca gcacgacagg
     1921 taatggcgat aaaaacatcg ccatatcatc atgtaaggat gggatatttt ttccggattc
     1981 agcaccacac aggccgcctt ctgttgctcg ctcagggcat gtaaatcatg ctcaaaccac
     2041 gccccctgga gcatctgtct gcaaaatcaa ccgaccacga caggaaaggc agaaacaatg
     2101 cctgatattt ctgctgagcg cagagtcggc actgataatg tgctcacccg gcggagcgtg
     2161 atcccagccc cgttttagac cgttctgaac cgccccgggt ttcctggaga gtgttttatc
     2221 tgtgaactca ggctgccaga tcatcgtttc cgatggaagc ataataagct ttttctgctt
     2281 ctgccggagg agtatgccca gcctttccag caatcgtcga ttgttatacc agtccaccca
     2341 cgtgagtgtg gccagttcca cttctgcacg gttttttcca gctcttacgg tgtattacct
     2401 ccgctttgta aaggccattg atgctctccg ccatcgcgtt gtcatacgag tcaccagtac
     2461 ttcctgttga tgccagtaat ccggcttcct taagccgctg tgtgtaggcc agcgatacat
     2521 actgagaacc tttatcactg tgatggactg tgccggacgg tcgacgggcc cataacgcct
     2581 gctccagagc atccagcacg aatgtcgttt ccatagacga tgagacccgc caccccacga
     2641 tgtatccggc aaacacatca atgatgaacg ccacatagac gaccccctgc catgtgctga
     2701 gtagagtaag aggcagggcg tagtcggact atttccctgc ctctcctccc cgaaccggac
     2761 gtgcaccttt cagcgcatcc ggctctccat ttaaatgctg gcgaacgcca ttgccacttc
     2821 tgtaaagcgc gatgtatacg tgtttctgtg tctggtctcc gtcctcagat agggattacc
     2881 ttcgggtagc cgccagcgga acagcttctt gccttgcccc accaaccgta cagtatttcg
     2941 ccgctgagct tgccgtgatt ggttttacca aataaaaccc acgttttgct ctgacccggt
     3001 ttcggtgatt tacaccacca cctcatcagg gaagcgatac ctgtacggta tttgcgggcc
     3061 agccagtgag ccagcttcca gaacacgaca cggtcgatat aactgaagac tttggcctta
     3121 aaatcaacga actgatagaa catggcccag cctttcagtt ttcggttgag ttgttcagcc
     3181 atatcgactt tgctttcact gtagttgcct gataacagtg ctgtcagcga tgcggcgaag
     3241 tttctggctt tctcctgcgg gatcgttgag accactcgca tctcgccata acgactgcgt
     3301 ttgcgaatga tcctgtgccc cagaaagata aagccgtcat taacatgggt gattttagtc
     3361 ttatccatgt tcagcctgag tttcagactg ccttcgagca caccccgaca ctcctccctg
     3421 atggcttccg cctgtgcttt ggtgcctttg acgatgagga caaaatcatc ggcatagcgg
     3481 cagtacgcca ccgcgggttt ccactgccag ttttctctga ccgccgtact tcggccccgt
     3541 tggatactgt tattccagta ccaccgatct tttctggctt tcccgctcag gtagcgctca
     3601 tgcaggtatt gatcgaactc attcagcatg atgttcgata atagcggcga tataacaccg
     3661 ccctgtggca caccttcact ggccgcccga aagagaccga catcgatatg tcccgccttg
     3721 atggttttcc acagcagagt catgaaacgt gcgtcactga tcctgcggcg tacagccttc
     3781 atcagcagtc gatgatgtac ggtgtcgaag taactggaca ggtcgccttc aatcacccag
     3841 cgtccccggg tttcaccaca gtctgtgagc tgtaatttca ccgtgcggat cgcgtggtgg
     3901 acactgcgct caggccggaa gccatatgag agcgtatgaa aatcactctc ccatatcggc
     3961 tccatcgcca tcagcatggc ccgctgaaca atacgatccc gcaacgcggg gatacccagt
     4021 ggtcgcagtt tgccgttgct tttagggatg taaacccgtc tggcgggcaa gggctggtag
     4081 tggcctgaga gtaattcatc cctgaggatt tgcagctcaa cagccagtct ggcctgtagc
     4141 attgttttgt tcacgccatc aacgccgggg gtatgggccc cctttgatga aagcgtgatc
     4201 cgcgccgctt cagccagcca ttctggttgt gttatcagac gcagcagccg ttgaatccgt
     4261 agggacggat cggtggctgc ccatgtggca agcttgcgtt gcatttcgct gattatcaaa
     4321 ggtcttcacc tcgttaggtc agttaattca cgtcgcaaac acattcaaac tgcttccctt
     4381 cgccatgtaa tgggctttcc ccatcgcgga ctactacgga agctccgcca gccagcgcgt
     4441 catcggagcc atgccccctt aacatccgtc gctgaccttc cccggtttac ctgcctggac
     4501 tcaggcatac tgaggaggct gcccgtcgca ctctttatcc ttgcttgccg caagttggca
     4561 gaagtcagca acgcaagcgt gatagacgct gctgccccgg tgtttcgcat acatgtcaaa
     4621 acaccttcga ccggtagtgc ttacgtatca ctgccagttc ctcctgcacg gcctgtcaga
     4681 tcacgtaggc cgtggtgacg ttttcaaccc acagaggcgg attaacgggt tcatgttctt
     4741 cagcctttca gtacttaacc ttgaggatca tctcggctta gtgatctcgc ctcaatcccc
     4801 gttgtcagcg ggttacatca ccctgcgggc atgccgcagg tcactgccgc tcaggttctc
     4861 caccgtcaca cccggtggga ttgttgggtt tctcatcgtg agttaccggt tcaatattcc
     4921 agacagactc gcggttcatt taagcatcca tgcccgccct gaactccggg cacaccgtaa
     4981 gtaaaatcag ccacccacaa ctggtcagaa cgttctgcca caaactgacg gtttacgcgg
     5041 tcgcctgcgg caacggcttt ccggctgacg gtagtgcgga cctttttacc ccggagaaca
     5101 ccggcaagtc ccataaccgc catgaggcgc gccactgtac atctggctac cctgattcct
     5161 tcccgtaaca actgacgcca gactttacgc acaccgtata cctgatgatt cccatcgtat
     5221 acgcgcagta tctctttctt cagccagtca tcgcgctgcg cacgggcact gcgtttatca
     5281 ggatgatgtc gctgtgtgct gacagtggta atacgttgac ggggcaatat gtagttcact
     5341 gcataccggt ccgaccccgt acagcttacg cagcttatcc agcagtggca tcactttttt
     5401 cagaggcggt cgaactccgc cttcgcaaaa taagcggaag cctggcgaag gatatcgtta
     5461 ctgcggcgca gttcacgatt ttcacgttcc agctctttca gacgctgacg ttcagcggtg
     5521 gtgagcccgc catcaccgcc tccggtatcc cgctcatgct ggcgtaccca gacacgcaga
     5581 gtctccggtg tacagccaat ctttggggca atggaacaaa ttgtcgccca ttgtgagtca
     5641 tattcgccct gactttccag aaccatacgg actgcccgtt gacggacttc gggggaaaaa
     5701 cgagtatttt tagtcatcct gtttacctct ttctcaggaa gtttagtctc caggattccc
     5761 gggcggttca gttttttaag atggtgaggt acttcgggtt ccttgccaac cgggtgtgtg
     5821 gagagaagct gccgcaggtg taccgtgctc tggggatgga taaaccggaa gcagtggcga
     5881 aagtgtgcta tgcacaaatg gtgaaacagt tcctgagtcg tgacccgttc gaatgcgtgc
     5941 tgtgcggcgg ccggatggta taccgccggg ccattgcggg gctgaatgta tcagggctga
     6001 agaaaaacgc gcgggatatc agtctgctga ggtatatgcc ggcctgacac aggctaagtg
     6061 tgcccgggaa tcggtgcaag tataaaaaac agcctgtcac ggtataaaaa tcgaccatgc
     6121 agaaattatg ctggttattt taccgctgct ggtccctcat tcagtgactg ccccagggtt
     6181 tttcatgctc tccttatagt acaataattt ccatatccaa actcacccct actttgactt
     6241 ttatcatagt caaaacctct taacgtgagt tttcgttcca ctgagcgtca gccctctaaa
     6301 actactgaat aatcagttag aaaacaaaca atcggaaaaa tctggggttc cggcctagaa
     6361 cccatgaaca ggcatagctg tgatttcatt taattattgg cacaaatcag ttgatcgtac
     6421 aatgctgtgc ctgtctcgtt ttctggagat tcctcagcct catggagcgg cgtaacaggc
     6481 gtaccggcag gacagagatg tttgcttttc ctagtccggc cagtttagtg gaataacgga
     6541 gtttttatcc catgtttttt tccccccgat cacgactttt tcaaatcaat gctcagaata
     6601 cgttctttag ctccttccac aaacacatca ggatcccaat cgcggttaaa gccttctttg
     6661 atgccaatgt aaagggtatc catatcgtcc gacaacacca tctggtttgg gtagaccggc
     6721 atgttaaatt cacgggtgat gctgtatttg gtggcatcca ctacgctgat ggtgccgcta
     6781 gtgaagttgg tgacatacag ttcgttatat ttcggattgt atttcaccgc gttagctccg
     6841 gctcctgtgt gcacatagcc aagctgttta ccgtcgcgta agtcaaaaat atagagtcca
     6901 tcttttgtac cggaacgatc gtcatggtcg aataccacca caaaggcacg gtcagaagcg
     6961 gagtccaccg ccagattctg cacacttgtg atttgtggtc tcggatcttt caacgggatg
     7021 gtacgcagca gcgtctgatt tttcgcatca atttcgttga tgtaatctct tccgccaacg
     7081 tagattttct ctgtgttttt tcatccatcg tcagaccata cgctgtacct ttgtaagcat
     7141 ccttaacctc gccttttaag gcaagcgtcg tcccgtcgag cattaacagc ttatgcagag
     7201 gcttcatgcc ctcggccgtt ttcagcatat tgctataact cacaaacagg gtatcggaat
     7261 cctggctgta aaccatatgg cgaaaatgct caaaacgcga atctgcagcg tttgccgctt
     7321 taaaacttaa cctgtcgctg gttcttacca gtttgccggt tggggtgtca aacatactga
     7381 tacgcaggga cgctgactgg gtgtgtccga tatagagctg atgtttatcc tgatttatcg
     7441 ccagcgaaaa tgcccggtat ggcatcgtgt atttattttc gactttcagc gaatctgaat
     7501 taaacgaata cagatagcct ttattggctt cacgatttac acgatcggtg actgctgcaa
     7561 acaccttttt actggcatta tcaaacgcca gttcatagac gccttcatca ggggactgaa
     7621 ggtaattcgt tttcagggca aatcgcgaaa gttcgcgttc aggtggatcg atagccatgg
     7681 ccatcgtggg taaaaatagt gaaattaaca ggtatagcgg tgctttggat aaagtgaaaa
     7741 tattcatttt tcgttcctgc aataaaattg acataagaga gaaaacgtat tgtctgaacc
     7801 tagcggaaat tgtcatcaga aacgaatgtc cccgccaaat atccatgttc tgccacgcgc
     7861 ggaattggct gggtgggtct cgtcaccaag acctggcatc atgttgagct tattcagcgc
     7921 ctccgaataa tctctgttca tcaggttttg taccgaaagt ttcagtgtca ggttgcggtt
     7981 gtactcgtaa gtaccataga gatcgataat cgttgggatc tgcggcaaat cctgtttgat
     8041 tattgcgccg gtatgttcgt cctgctcaaa atcaggcgac aggcgacgag ccttgcctgt
     8101 gtattttatg atagtgccca gggtcaacgc gttatcgaag aagcgaacac cagtatccag
     8161 cgtcatgtat tttctgggca gttcggttat atcccctgcg ccaaagtggg tgctggcgat
     8221 ggaggttggc tggtctgttt gctgctggct gaaagagagt cggccaaaag caaaacctgc
     8281 atcataatcc atctccagtt cgaagccctt tgcgataacg tcgcttgccg agttaacgta
     8341 gatgtacata ttgtcgctgt attcatcgct aatgccctcc cagccattgc caatcacctc
     8401 aggcagactg catttacgac ctccagaaca aaccagataa gactcgctgt agatgtagtt
     8461 ctggatcctg ctgcggtacg ccagagcctt aaagcgcagg gcatcctgtt cgaccagtaa
     8521 atctctggta tcaatgttaa aacccgcctg ccaggtttct gcacgttcag gcttcaggaa
     8581 tgggttcatg gatgcgcctc ctgaattaga gaagaacatc tcctggatgt tcggggcgcg
     8641 catggatttg ctgtagccaa tgaacggctg aagccatggt gttacctgag cagaaagctg
     8701 aactgaaggg ttgaagccac cctctttatc gtcaatatcg tagctaccct gtggcacgca
     8761 gataacgcgt gaatcgcagg cgggcttgta ccctgtgatc ctgttacgtg tgtagttgag
     8821 attgaaatct gcctcccaga tgccgcgcgt aaccttcagc ccggtataca gcgctgaaat
     8881 atcctgctgg ccggagggtg cgaacggatt gttctcgatc gattcctgat tcgctttcgg
     8941 gtcgcccgcc gctgagtgaa tggtccggtc atagcgggta cgcatcagtt tgctgcccag
     9001 cataaactcc aggtcattgt ccgcgacagt gaaccggctg gtattgttga tatccagcgc
     9061 gtcagaacga ttttgcgctg aggttttgta gaaagtatac agcgagccat cacgatactt
     9121 ttgattaccg cgactggtac tggccgttac gttaaagtca attaattcag aaaaaggggt
     9181 gtaatgatat ttaatgtaat agtcgtcact ggttatatca cgacgtgtaa atttattttc
     9241 ataggttcga gcggaaagtt cgaagctgtt aaattcgtct ggtctgatat ccattttata
     9301 cagttgggat ttggggttct gcttcatata tttatcataa ccaaactctt tgctgttaat
     9361 tccagaacca tttgagaaat tagagtacac agaactgccg ctcacagcag ccataacgcc
     9421 aatgcttccc gtatccgtaa aagcgtcgct ttttccacca agggcgatca ttccgctgcg
     9481 tcccagccca ttactaccga cagagaaacg tgaacgaagg ccatatgtat taccgttaaa
     9541 tattacatcg tcaacgccaa tagtacgcat atttgcacta ccggcaaggg cgttgatccc
     9601 ttcagagcca ctgctgtcac cgcgtgtaac atcaactgct accagtaagt taggatctat
     9661 aagtacgcca gccatattgt tagttgaacc atgcgtcgtt gttccggagg tagaggttcc
     9721 gtaaaaactc tgggtaatac catcgaccat agtgtttaca cgaccaaatc cgctcatgcc
     9781 tcgaatattc acactgattg ctccctgacc aggatctatt tgagtataag taccaggcat
     9841 actacgcact gttgcgtcaa gtgattgcag gtttttgtcc gttgtccggg aactggtcgc
     9901 gcctgttttc tcgagagctt cctgctcact ggtcgtcttc ccgacagaaa cgctgagcgg
     9961 actgaattct gccgctcctt ttttgtcgga attagttttt tcactgatgg attgtgagta
    10021 agcaccgcag ctgagcaata atatgcctga gccgatagcc agttttataa cgttcataaa
    10081 tttccttggg tataatatta ataaagataa gtataactat ttgtttatta attatgttct
    10141 actgtctttt tgattttttt gacagtggaa aagtttgata aaatgttcag cataaaaatg
    10201 aaaattaaat ttcagttaaa tgaacttgaa cggccaatta tccctttact ccttcaactt
    10261 aaaggtaatc ggcattttta ctttaaataa tcctccctcc aatatttcag gcggtggttt
    10321 gggaagtggt tgagcgcgtt ctaaaacagc aatagcttcg cggtcaagag aaaaggttcc
    10381 tgaagagatt tccaagaaac tactgacaat agtgccttcc gtgtttacgg taaaagtcac
    10441 gacggctgtg ccggttcgtg cacgttttct ggcatcgcca gggtaacgtt tataacggtt
    10501 taggtggcct tttactctgc tttcccaaga tgcctcagaa ttatctcgct ttgttgagtc
    10561 actgttaaaa ggcgcagcaa tacgggacga ttcgaccaga gcctgaggtg cagcattact
    10621 ggaaacggct gtggggttgc tgtcgctggt ttgagccttt atcttacgag gtggacgtgt
    10681 ctttttcttt tctccatcgg atgacttttt cttcctagtt atttcaatgg ttgcatcact
    10741 gtcttcagtg acaggacgtt gttgtctgtc ctcagtttgt tgcttttctt cttcactgcg
    10801 gactcctgtt gagcgattcc caccggaagc gaaagtggag aagaaggagc ctctataatt
    10861 tctgcccatt gcagcatgat cgccggtgca ggagacatag cgggctgaac ttcggaaaaa
    10921 cgccagataa acgcaaggaa aatcagtcca tgaagcagta gagaacagat aaaccagctg
    10981 ctccatttta ccgactgtga gaagtggaga atattcatca tccatggttt acctttttgt
    11041 tgtatctggc gctacaaacc acacgtagtc agcatgatct actgtgatgt tcattccttt
    11101 ttctgcaagc atcaacacca ctggatgggt gccggtggca agatcttcca tgtgtaacgg
    11161 tacgcccatg ctttttgacg cgtgataacc acctgcaatc aacaacgacg gtaccggggc
    11221 actcagaagc tggcgggcca tgtagcgatc ccgctgctgc tgaatagaga gcattgacgt
    11281 cagttgctgg ctttcaaggt tgccttcatg catagatatg atggtttcac gcagagcttc
    11341 ttgtaccaca ggtgcagtgg atttttttcc tttaggaaat tcgttttttt tgtacagtgc
    11401 caatatctgc tcccggccaa tgttggcatt gagcagcggg taaggcccac gtaatagctg
    11461 catgacgatg tcgccataca tctcccagga ccaccctttt tgccagttaa gtagttcctg
    11521 aacacggcta tctcgaacca caggattatc tttcagccaa catttaactt ggttaactcg
    11581 gggctgttgc tctgacgtca acatctcaag caacacactc ccctgtggtc gctggatgag
    11641 caaattttga ataagccaaa gctcaatctg atgatgctcg gcattatcgt gtttttcacc
    11701 aataataaga tgttgagcgg tagcaagatc cgccaaaagc tcgctgctag aaataatttt
    11761 gccactgtgc aaatcgtaaa tctgcccgtc agtcaggaaa gctttctgcc ctggcgcatc
    11821 ctgctttatg gtgacattct gtctgcaggc tcccagacta acactagcta acgttatcat
    11881 agaaataagg atgaactttc tcatattccc atctgaaaca atatgtttcc atatatttat
    11941 tgacaaaaca ttaattatga taaaacatca aagaatgaat gtaaatgatt atcattacca
    12001 acaaaaagaa tgcactagcg agtgatgttt accagccgat attatgggtc cgcttggaaa
    12061 acggatctat ggtcactccc gtttttgcaa caccgatttt gacgataagt gggcttgctt
    12121 gaatctatcc ggagtctgaa tgggatttca ttcctgcgcc ccgatgagtt ccgcgcctga
    12181 tgtacatgtc gaagaaaacg gccggcgggg ggaatacggc gcgctacctg ggtcgttatc
    12241 gggggtgagg gccaatggaa cgaaaacgta cgttaatgtg tgcgtatcag ccacatactg
    12301 tgcgaaagtt tccggcgtga agttcctgtg cgtgtatttc gcaatgctct tgccaatagc
    12361 ccgacattca ggcggtgaaa gcggaacggg aagcgatgcg ttgtacattt cgacacgctg
    12421 aatcacggca tcaagccact gtgagaattc gggccagccc tgacgaatcg ccctgtaagc
    12481 ccatttgcgc gtcatttcga acaggtggca gtttcgtcga tgctacggcg cgctgaggcg
    12541 ctcaaatcga gataatcagc cagttcatcg agggtatagg cttcctctcg ccactccatc
    12601 acctgccatt ccaggtggaa cggattttta caaatcagtc cgctgtagtt cacatcagca
    12661 caaagtttct cacacagcga acgttcaatc gcagcggcgt atttcagcgc cttaaccgag
    12721 ctgtccggcg cggttctcac ggcgatattg agcgcgtaga gcaggtgagc atgaccgttc
    12781 acaggatttt ttacggtgat gttcggcgcg ggagcgttcc ggtcgctcca gtcaatcgct
    12841 gccccctcgc gatcaacgtc aaaaaccagc cagaactgcg catgaggctg gttctgccgg
    12901 atctggacat gatttcaggg gcgtttgttt ttcagtcgct tacactacac ccaacggcaa
    12961 atcctgtcga accttcccga aaacccgatc catttaccat aactcccgtt gtacgtaccc
    13021 tgtaaaacgc cctcaatcgc tttctggcgc aaaaaacgca aaaagacaag aaaacaccag
    13081 gctaaaccag aaaaacgcgc cagaatcgtt tttagatggc tgcataacta tgcacgaaag
    13141 cgacccgcga tcggttttgt gtgttctgaa taccgaacgg gtcaaaatga cacgttttct
    13201 ctccctcaat ggagcgttct atacagagat ttttgttccc ctatccatta ttctgattac
    13261 cgggtttcca agctgaaaac aggacttttc tgcgaccagt ttttgcgaat atagtcacat
    13321 aaaccaccga ttgagtgaca aatacaggag aatttatttt gaaatatgat tttatcaatg
    13381 gcagttctat tttaattata gtctggatga ctatagctgt aataatcaga gtcacaaact
    13441 ggaaattcaa caaaaaaaca gccccagcta taagcttatt cttagctttc cctgcatcta
    13501 tagttattct gttagtttat atttttttct tcgataagtg atgtgttttc atgattaatc
    13561 aagtttctgt tcaaatgctc ctgctggccc agcatggaaa aagaaattac gaataaatgc
    13621 acccagtgcc attaacatct atctacacaa aaatagagga aaacaatttt gatatatcaa
    13681 ataattacaa gcagctccat tctttttatt gtttggggga ttacatctat aataattaga
    13741 acaaagaatt atttttctaa gaagaaaaca gaccttaata taagcttttt tatagccttc
    13801 cctatttcta taacaatcct tttattttgc cgaggtatat tataaatata acataataca
    13861 tctatatggg gtgtacatat ccccacataa aaacacatac tctcattaac acgggaagaa
    13921 actatgtttt ccaattctca ctacatgtac ataatcattc ttgtactatg gtttagtatt
    13981 ctcaagtact tacagagaaa gaatagcata ttacatcctt tattttcact aatcctgaca
    14041 ccactaacca ttttaatcat tagacttatg atagatttaa catacaacca ataaattata
    14101 aacaaaataa aaatagggaa cattatatgc tttataaaat tttcacatta aacacaaaga
    14161 taaaaacaac tatcattaca atatgtgcat tatcatataa tcttacagcg caagcttccc
    14221 cgtcatacag acctcgtgat cgagttaata agactatgat agaactacaa actaacggag
    14281 tagaacggca acttttagat aattcttgtg gcataagttc tggggtattt aaataaaata
    14341 taagacaggc tgtctatctt acagacagcc tttttataat aacagaaaga atatatatca
    14401 tacttaacgg aagagataat atgaaaacag tacccgtata aacagcaagc aatcccattt
    14461 ttccaggtgt atcagtaaaa aaaccgctgt tccagaaatc aggccgggta aatttcagag
    14521 ctgtatcttc aatataccat tttgcaaccg gatacaaaac cattccgcag agagaaatac
    14581 accagaacag taatctgtat ttaaaatcat aatcccatga catatacagc atatatcccc
    14641 ccgtcaccca tccccaccac atattattaa aataatattt tctgttcatc tgccagtttt
    14701 cctttctttt gcacttttgt cagtgtactg atgcatgaca acataaccac agcatgataa
    14761 taataatcaa taacaataag ctgtgtcacg tttacatcat ggaacggagg tgctcctgtg
    14821 acttttgagc agaaaaaagc ccgggccatt gccctgatgg acagcaaaaa gatgtggcgg
    14881 agcaattatg cccctcctct tctgcgtatt ctctggcggc tgggtatccg gcttccgcca
    14941 ttacccttta tgccgttctg gcaggtcacg gtgctgacgg ggggcttatg gggcatttcc
    15001 tggggatgtg caatgtggtt tatctactgg gggccgtcag gaatggtggc aggtgaggcc
    15061 attattataa gtatcacggg ggggtttttg tccggactgc tcatggcctc tttccactgg
    15121 tggcgcagga aagttaaccg gctgccacca tgggatgatg tgtaaaccgt gcacaggcgt
    15181 gttcttacgg agcggcactt tcatttatct gtacgcgaac ctccattcct gcatcgtgac
    15241 aggcctgcag ccactgcgcc acttccagcg gatcgccctc ccggcgtacc accctgcctt
    15301 ctttattcca taactgcaga caggtgctgc cgtcgagacg caccacaaaa tccccacggc
    15361 aggcctgata cgttatgccg ttcagctcca ccgccagatc agtggcagaa gtgccgcctg
    15421 cgggcagcag aggctgtgcc acggcccggc cggcgtccgt cagctccact gccagctgca
    15481 ggttcggagc gcgcagggta cgcagccagc cggcatcctc cagacgacgg caggaggcgc
    15541 gcaggtttgg cccgtagacc ggggcttccc cgctttgctc cagcacccgt tctatgtccc
    15601 gcgtcagcac gggtcctggc cgtttttcat caagggcagc cagcacaatc agcactctcc
    15661 gctgcagtgg cgacggtcgg cggctctgag tcatttccag tcatcctccg gccagatgag
    15721 ctttctgagg cgctgatggt cggcgtcaat gatctcctgt ctctttatgg cattcattga
    15781 ggtatagcca tttatggcca gttcatgcca gaagatcagc acggctccgg ctttggctga
    15841 ctcgcagaga taagttacgc cgtggctgtc cagattgcat tcccggatgc gtttttccgc
    15901 aaaccgggtc agttgttcat agctgagtga aaacgtcatt tcctgatcca tcctgtacgt
    15961 tccatctgat aatgttctga caggtaaaaa tcatatcctg aaccgccccg ggaatcctgg
    16021 agactaaact ccctgagaaa gaggtaaaca ggatgactaa aaatactcgt ttttcccccg
    16081 aagtccgtca gagggcgatt cgtatggttc tggaaagtca gggcgaatat gactcacagt
    16141 gggcggcaat ttgttccatt gccccaaaga ttggctgtac accggagact ctgcgtgtct
    16201 gggtacgcca gcatgagcgg gataccggag gcggtgatgg cgggctcacc accgctgaac
    16261 gtcagcgtct gaaagagctg gaacgtgaaa atcgtgaact gcgccgcagt aacgatatcc
    16321 ttcgccaggc ttccgcttat tttgcgaagg cggagttcga ccgcctctgg aaaaagtgat
    16381 gccactgctg gataagctgc gtaagctgta cggggtcgga ccggtatgca gtgaactaca
    16441 tattgccccg tcaacgtatt accactgtca gcaacagcga catcatcctg ataaacgcag
    16501 tgcccgtgcg cagcgcgatg actggctgaa gaaagagata ctgcgcgtat acgatgggaa
    16561 tcatcaggta tacggtgtgc gtaaagtctg gcgtcagttg ttacgggaag gaatcagggt
    16621 agccagatgt acagtggcgc gcctcatggc ggttatggga cttgccggtg ttctccgggg
    16681 taaaaaggtc cgcactaccg tcagccggaa agccgttgcc gcaggcgacc gcgtaaaccg
    16741 tcagtttgtg gcagaacgtt ctgaccagtt gtgggtggct gattttactt acggtgtgcc
    16801 cggagttcag ggcgggcatg gatgcttaaa tgaaccgcga gtctgtctgg aatattgaac
    16861 cggtaactca cgatgagaaa cccaacaatc ccaccgggtg tgacggtgga gaacctgagc
    16921 ggcagtgacc tgcggcatgc ccgcagggtg atgtaacccg ctgacaacgg ggattgaggc
    16981 gagatcacta agcgagatga tcctcaaggt taagtactga aaggctgaag aacatgaacc
    17041 cgttaatccg cctctgtggg ttgaaaacgt caccacggcc tacgtgatct gacaggccgt
    17101 gcaggaggaa ctggcagtga tacgtaagca ctaccggtcg aaggtgtttt gacatgtatg
    17161 cgaaacaccg gggcagcagc gtctatcacg cttgcgttgc tgacttctgc caacttgcgg
    17221 caagcaagga taaagagtgc gacgggcagc ctcctcagta tgcctgagtc caggcaggta
    17281 aaccggggaa ggtcagcgac ggatgttaag ggggcatggc tccgatgacg cgctggctgg
    17341 cggagcttcc gtagtagtcc gcgatgggga aagcccatta catggcgaag ggaagcagtt
    17401 tgaatgtgtt tgcgacgtga attaactgac ctaacgaggt gaagaccttt gataatcagc
    17461 gaaatgcaac gcaagcttgc cacatgggca gccaccgatc cgtccctacg gattcaacgg
    17521 ctgctgcgtc tgataacaca accagaatgg ctggctgaag cggcgcggat cacgctttca
    17581 tcaaaggggg cccatacccc cggcgttgat ggcgtgaaca aaacaatgct acaggccaga
    17641 ctggctgttg agctgcaaat cctcagggat gaattactct caggccacta ccagcccttg
    17701 cccgccagac gggtttacat ccctaaaagc aacggcaaac tgcgaccact gggtatcccg
    17761 cgttgcggga tcgtataagc atccgtgcca aggtggagca cccgtttcgc atcatcaagc
    17821 ggcagttcgg cttcgtgaaa gcagatacaa ggggctgctg aaaaacgata accaactggc
    17881 gatgttattc accctggcca acctgtttcg ggtggaccaa atgatacgtc agtgggagag
    17941 atctcagtaa aaaccggaaa taacaccaga aatggtggaa aaaatagcct aaataggctg
    18001 attcgatgtg tttgcgggac aaaaatcggc ccagatccgc gaaattttaa tcaacgagtc
    18061 agcttgggaa gacatgacct gcttattcgc accttcccta aaggcgtctt tggcttcggt
    18121 cagcgaacac tgctgttttt tctttgcagg acggtgaatc tttgtagtcc gtcatctgcg
    18181 ccagcagctg atagctgtcg tcaagctgca tctggctgcg ctctttttcc atcgcctgca
    18241 ccgctttctg gctaaacgcc gcagagtcat cggtgatcac cggattaaac gttgggtcca
    18301 tcgtgcccat ttttttcctg atgatgtacc ggaatgtcgc acccagggaa agcgccggtg
    18361 ataaagaatt gtgccgtcgc aacggtgcgt tgcagactgt tggcataggt atataccgtg
    18421 tccggcgtcg ggcattcgcc tgacgtgacc atccccagct ccgccagcca ttctcgcatg
    18481 tagtggccca tataaatttc cagcacaccg cctttcgtgg tgagctgccc gccgggcaca
    18541 tcccactccg gccactgatt cggcgtggac tgctccagca cgctgccatt attggccaac
    18601 ggcgcgcgca agttgtgtcg gctcatcatc aacacttgtt gcagttgata accttccggc
    18661 gttgtctgcg cttgcgcggc ggacgacaat aaaacagccc ctgccacagc ggcggcgagt
    18721 atcaattttt tcatccctac aacctcttgt tgttatcaat cctcatagag tgtgacagaa
    18781 atatgacatt tttccgggaa cggtttcgca aaacgggaga ttccagaaga taaccggcag
    18841 gtcagcgtgt tccggttact ccgagataaa aacctcatac ttaatattgc gggcgcaata
    18901 aaaagtgccg tccgtcagat acagttcacg aaatcgcgtg ttatcagaga tgttgtccag
    18961 cagggaacgt tccgtatcga caaattcttt ttgcacgcgg taatgaacgg cgttctccgt
    19021 ttcaaagaga catattccgt ggtggcgtag ggcttatttt tgatttcacg tacacgatat
    19081 attgcacggt actggccgtc agccccgttt tcgccgcgat ctctttgaga ctcaacgtct
    19141 cagaggcata aagcgcctga acctgcgcta tgcgtcggtg attatacgcc gtcacccgaa
    19201 ggctcagttt cagccgatag gccatattcc gcacggcggt aatattagtg tgaagcagtt
    19261 gcgctatctg ctctgtcgtg aggatgcccg cgtttcccgc agaatcgcaa ggctttcgtc
    19321 gttccagata aatgccattg ggtatctctc cgtacgcgtc gttcatcgcg ccgccaggcg
    19381 cgcaaacgtg gcctctaact cagacggctt acgcataccc tggtgtagct ccagaacgcg
    19441 tccttcggag tcaatcagta cggaggtcgg cgtgccgatc acctgataac gttcctgggt
    19501 aatgttgagc tgatcgcgca ccaccggata ggttatctga tgttttgcca gcagatcgtt
    19561 gatcctgacc gtttcagggt cggtattgac cgccacaacc accactttat cgccccattt
    19621 tttgctcagc gcttccagcg tgtccatttc cgctaggcac cccccgcatc ccgcagacca
    19681 aaaattcagg tacaccgcct ttccttgcca gcgttcaagg cctgactcct ggccttgcag
    19741 atcaaacgcc gccagcgccg gggccggtgc cccgaccgcc agcttttctt ctttacaccc
    19801 gcttatcagg atcgccgccg cgagtaacag cacattatgc cagcgcatgt tgattggcct
    19861 cctcacccag atatttaccg tgttgcagcc gcagaatacg gtcggcaaac tgcccaagcg
    19921 cagggttgtg cgtcaccatc acaatcgtgc gcccctgacg atgcagatcg gtgagcagat
    19981 ccagcacccg ctgctcattc tcttcatcca ggttgcccgt cggttcatcc gcgaaaataa
    20041 ccggcggttc gttgaccagc gcccgggcga tacacacacg ctgctgctca ccaccggaaa
    20101 gctggctcgg caggtgcgtc acacgatgcc caagccctac ctgttccagc accttcctcg
    20161 ccgccgcttc atccaccacg ctgtggtaat gctgggcgag catgatgttt tccagcgcag
    20221 ttaagaacgg gatcaaatgg aactgctgaa ataccaggcc gattttctcg gcgcgaaagc
    20281 gacggcgccc ctcttcatcc agcgcggcgg catcggtgcc atcaagaaac cctgcccttc
    20341 cgtcgccgta tcaaggcacg tcagaatatt catcagcgtg gttttaccag aaccagaagc
    20401 gcccataatg gcgacaaatt caccctgcgc aatgcgcaga ttaatgtcat ccagggcggt
    20461 aacgtcaccg aaccgtttgt ataagtggcg ggtttcgatc gccacctgag ggatatgcgt
    20521 aacggacatg gcgctactct cctttcagca ctttagcagg ctcgacgctt accgcgcgtc
    20581 gcaccggaac aatcgccgcc agaatggcga ccagtaaaga caacaccaga gtaatgggca
    20641 acaccggcag acgcagtgat atggcggcat taaacaccgt taatcccaac agttgcgcca
    20701 gcaaatatcc cagcacccag ccgcacgcca ccgccgccag cgcgatgatg ctggtttcca
    20761 gcagaatttg ccgcacgata tcgccgttgc tggaaccaag cgctttttgc agcgcaaact
    20821 cgcgcgcccg ctcgccgaca atcgccatca gcgtggtatt cacgcacagc gaagagagcg
    20881 ccagaatcac gatcgagacc agtcccatca gacctttaat tttatccagc acctgccctt
    20941 cggaagcaga gaccttacgc accggacgaa tctccaggtc aggatactgc gcctgcaacc
    21001 ggctggcata gttctccacc tggccgacat cgttactgac gctcagcaag ccgtggctga
    21061 ttttgcccgg ctgatgcagc caggcctgcg ccacgtcgag gctgacgatc agcatgttgt
    21121 ccgtcgcatc gccagactcc acaatgcctt taatctgcaa attcttacgc tgattgtgat
    21181 ccaccagcgt gatgctgtcg cccggctgca cgttgaggcg ttccgccagt ttgacgccga
    21241 tcatcgcatt acggtcgtca aaactaacgc caatccagct accggtgacc tgccagtacg
    21301 gcaccagttt ttgcagcgac tcgaaccaca cgccaaccat caccactttt tccagctcgg
    21361 tacgcgccat gccgtacaac cacggactgg cgccatgcac cagcccctgc ggcgcctgat
    21421 cgagaatgct ctgcaactcc tgctgcggca tactggaacc gtgccccggc ccgatgtaaa
    21481 aaattcgcgc cgaaggtgcg cagttcttcg ctcattttgg tgttaatgtc gaaccagacg
    21541 gcaaaaagcg ccgtcacgat ggtcgccccc accatcagcg cggcaaacac cgctgacccg
    21601 ctgaaaacgc agacgcagcg cccgccacac cagcagccag agcatggtac gtttagcggc
    21661 catacagcac ctccacagga tacagccggc aatccgccgg gccgggaacc aggtgccgat
    21721 caacgcaatc agtaccgcaa tcaccagtac gcacggcacc acaatccagg caaaattaag
    21781 cggcgcgtcg aagagcatga cgccaatcgc tttcgccagc ccccacccgg caatacatcc
    21841 cagcgcaccg ccagccagcc cgctggacgc cgcttccagg taaacagcag cataatttgc
    21901 cactgtcgcg cacccagcgc tttcatcaaa ccgatctctt tggcgcgttc cataatggtg
    21961 ctggtcatca gcgaggcgat ccccattgcg gaagccacca gcgccgcgac ggtaacgacc
    22021 gccatcagca actgaatttt atcgatcacc accccttcgg acgccgcgac ctgccatacc
    22081 gggcgcactt ccgcaccgga aatcgcctct tccagctgat gcgcgatcga cgacacatag
    22141 gccgtgcaat acagaggtcg tactcttcgg cattgagcgc gtccaggttt tcccgcgcgc
    22201 ggcgggacag ttcgttttcc ggcaccgtca gcgccgagac gcgaatcgcc tgcacttttc
    22261 cggggagccc cagcaggtgc tgtaccgtgc ttagcggcat caccagttgg ttatcttcat
    22321 cgccgccgct ggagaggata ccgctgacgg tgacctgcac tgcttcgcct tcggtacgta
    22381 atgtcagctt atcccgggtt tccagcccat ttgccgcgcc agcgcgtgcc cgactaaggt
    22441 ctgcggctct gcgcctgcgg gttcctgcgg ccagtcgccg gtcacctgcc agtatgggct
    22501 gaccgttttc tgccccgtct catatccctc ttcatcagga atatccactg gctgactgaa
    22561 gaaagtgccc agaatccgca ctggttctcc ctccacgctg gcttcgccgc cgagcatcgg
    22621 cgcaaacccg acaattgttg tttcgccaga agatatcttt gatgttcggc agctcggctt
    22681 catcaagaaa atcctgaccg gaaagcggat tactgctctc actaaacagc gcgggcagcg
    22741 cagcctgtcc ggcgggttca atcaaaatgt tcgcaccata agacttcagc tctctggaca
    22801 ttttgtcgcc gatatcaatg gacaccgcca gcagcgccga gatcaggctg gaggccagaa
    22861 aaacggtgat tatcgccagc actttgcggc gtaaattgcg cccccaggat tgtcgtaaca
    22921 tccgccacag catgattatt cctccctcat gtcggcagga acaaactgct ccggcgtttc
    22981 acggaagcgt tcatagttag cctctgacga gaagaaccag gtcttgccgc catagctgta
    23041 tttgtatcgc tgaggtattg gtcaaacgtt gaaccatcga ccggatcggt cactttaata
    23101 gtcatgaccg tcgagaagta gttcacccct gtcgccagtt ctttaccggg gatcaccagc
    23161 tctttttcat cattgtgcca gttttcaatc ggcaccggtt acagccaccg gccttgccga
    23221 tagacggaat aaaatatgca ctccgcaggc gacgcagata acctga
//
