LOCUS       CP067483               19722 bp    DNA     circular BCT 01-MAR-2022
DEFINITION  Klebsiella pneumoniae strain ARLG-3289 plasmid pC752_4, complete
            sequence.
ACCESSION   CP067483
VERSION     CP067483.1
DBLINK      BioProject: PRJNA658369
            BioSample: SAMN15868705
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 19722)
  AUTHORS   Shropshire,W.C.
  TITLE     Highly Conserved and Distinct Accessory Genomes Drive Independent
            and Parallel Endemic Spread of Carbapenem-Resistant Klebsiella
            pneumoniae Clonal Groups 258 and 307
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 19722)
  AUTHORS   Shropshire,W.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JAN-2021) HMH-CDI, Hackensack-Meridian Health Center
            for Discovery and Innovation, 340 Kingsland Street, Building 102,
            Nutley, NJ 07110, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2020
            Assembly Method                   :: Flye v. 2.7
            Assembly Name                     :: C752
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 291x
            Sequencing Technology             :: Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 01/11/2021 15:19:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 5.0
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 5,655
            CDSs (total)                      :: 5,531
            Genes (coding)                    :: 5,430
            CDSs (with protein)               :: 5,430
            Genes (RNA)                       :: 124
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 87
            ncRNAs                            :: 12
            Pseudo Genes (total)              :: 101
            CDSs (without protein)            :: 101
            Pseudo Genes (ambiguous residues) :: 0 of 101
            Pseudo Genes (frameshifted)       :: 40 of 101
            Pseudo Genes (incomplete)         :: 60 of 101
            Pseudo Genes (internal stop)      :: 18 of 101
            Pseudo Genes (multiple problems)  :: 16 of 101
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..19722
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="ARLG-3289"
                     /isolation_source="respiratory"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="pC752_4"
                     /geo_loc_name="USA: South"
                     /collection_date="2016"
                     /collected_by="MDRO network"
     gene            join(18701..19722,1..4)
                     /gene="istA"
                     /locus_tag="JJ182_28105"
     CDS             join(18701..19722,1..4)
                     /gene="istA"
                     /locus_tag="JJ182_28105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032490293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS21 family transposase"
                     /protein_id="UMD00033.1"
                     /translation="MLTQEQTVEIRVLARQGHSIRHIARTLGVSRNTVRRYLRDPSVAR
                     YQPREPRPTKLGPFESYLRQRVEQAHPIWLPATVLNREIRAQGYGGGLSLLRAFLATLK
                     PARREAGPAVRFETEPGRQLQADFVVLRRARSPMSAFVATLGYSRMTFVTFVPDESFES
                     VRDSLLLAFDYLGGVPREVLFDNMKTVVLERDAYGDGKHRFHPGLLQLADDLGFRIRLC
                     RPYRAQTKGKVERFNRYFRESFYNPLLTRMKGTGLLLDCAAANRRVRDWLADEANVRVH
                     ATLNERPIDRWRQEREHLQPLPSRVRRDEAPLLDNSLRPVPLESLQHPLSVYDAIGEAC
                     R"
                     /name="istA"
     gene            1..780
                     /gene="istB"
                     /locus_tag="JJ182_28110"
     CDS             1..780
                     /gene="istB"
                     /locus_tag="JJ182_28110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004152394.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS21-like element ISKpn7 family helper ATPase
                     IstB"
                     /protein_id="UMD00034.1"
                     /translation="MNLQHERIDALCQQLKLERVATHYPVLAQQAVREDFSFTDFLEHL
                     LRHEAGCRQQRSRELLTRMACFPGIKTLEDYDFSFNPGVPKALVQELGSLAFVERAENV
                     VLIGPSGIGKTHLAIALGYKAAQAGVKTRFITAADLMLQLSTAQRQGRLKEYFNRAILG
                     PRLLVIDEIGYLPFGREEANLFFQVVAKRYEKGAMILTSNLPFSQWADAFAGDTTLTAA
                     MLDRLLHHAHILTLSGESYRLKDKRKAGVVRKNSKPE"
                     /name="istB"
     gene            1167..2048
                     /locus_tag="JJ182_28115"
     CDS             1167..2048
                     /locus_tag="JJ182_28115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015256839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbapenem-hydrolyzing class A beta-lactamase
                     KPC-2"
                     /protein_id="UMD00035.1"
                     /translation="MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIG
                     VYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPW
                     SPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDR
                     WELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRA
                     AVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAA
                     RLALEGLGVNGQ"
                     /name="carbapenem-hydrolyzing class A beta-lactamase KPC-2"
     gene            complement(2298..3617)
                     /locus_tag="JJ182_28120"
     CDS             complement(2298..3617)
                     /locus_tag="JJ182_28120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004152397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS1182-like element ISKpn6 family transposase"
                     /protein_id="UMD00036.1"
                     /translation="MAASYLPYRPDQSYLLPPSLGEWLPEGHLAYFISETVDTLDLSAF
                     HARYAGGGPGNQPFHPAMMVKVLIYGYASGVFSSRKLARKLYEDVALRVLAAGNFPAHR
                     TLSDFRALHLTELENLFVQVVQLARECGLVKLGTIAVDGTKVKANASRHKAMSYKRMKP
                     AEDELHCEIKALLDRAKATDDQERNEPELDIPAEISRREKRLEAIQAAKARLEARQREA
                     DQARGRSEDDGRRPRHPDGSDKGGGSYKREFGVPDDRDQESFTDPDSRIMKHAGGGSEQ
                     SYNGYTAVDAEHQIIVAAELTNCAADSQALLGMLAAVQANTGEMPAQTLADAGFRSEAV
                     LAKVADHHGDVIVALGREGREDAKVNAKTHPHTAAIAAKLKTEQGDAAYRRRKSIVEAP
                     NGWIKAVMGLRQFSMRGLDKVQAEWKLVCMALNLRRMAYL"
                     /name="IS1182-like element ISKpn6 family transposase"
     gene            complement(3972..5120)
                     /locus_tag="JJ182_28125"
                     /pseudo=""
     CDS             complement(3972..5120)
                     /locus_tag="JJ182_28125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032495017.1"
                     /note="incomplete; partial on complete genome; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4158 domain-containing protein"
                     /name="DUF4158 domain-containing protein"
     gene            5282..5839
                     /locus_tag="JJ182_28130"
     CDS             5282..5839
                     /locus_tag="JJ182_28130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005221001.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="UMD00037.1"
                     /translation="MRIFGYARVSTSQQSLDIQIRALKDAGVKANRIFTDKASGSSTDR
                     EGLDLLRMKVEEGDVILVKKLDRLGRDTADMIQLIKEFDAQGVAVRFIDDGISTDGDMG
                     QMVVTILSAVAQAERRRILERTNEGRQEAKLKGIKFGRRRTVDRNVVLTLHQKGTGATE
                     IAHQLSIARSTVYKILEDERAS"
                     /name="recombinase family protein"
     gene            6073..6627
                     /locus_tag="JJ182_28135"
     CDS             6073..6627
                     /locus_tag="JJ182_28135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003159191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAC(6')-Ib family aminoglycoside
                     6'-N-acetyltransferase"
                     /protein_id="UMD00042.1"
                     /translation="MTNSNDSVTLRLMTEHDLAMLYEWLNRSHIVEWWGGEEARPTLAD
                     VQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLA
                     NASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTVTTP
                     DGPAVYMVQTRQAFERTRSVA"
                     /name="AAC(6')-Ib family aminoglycoside
                     6'-N-acetyltransferase"
     gene            6697..6918
                     /locus_tag="JJ182_28140"
                     /pseudo=""
     CDS             6697..6918
                     /locus_tag="JJ182_28140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001206318.1"
                     /note="incomplete; partial on complete genome; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase domain-containing protein"
                     /name="nucleotidyltransferase domain-containing protein"
     gene            6978..7682
                     /locus_tag="JJ182_28145"
     CDS             6978..7682
                     /locus_tag="JJ182_28145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005221000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS26 family transposase"
                     /protein_id="UMD00038.1"
                     /translation="MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDHS
                     TIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDF
                     YLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHR
                     QIKYRNNVIECDHGKLKRIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPL
                     GEMRLVSRVFEM"
                     /name="IS6-like element IS26 family transposase"
     gene            7737..7907
                     /locus_tag="JJ182_28150"
                     /pseudo=""
     CDS             7737..7907
                     /locus_tag="JJ182_28150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032489893.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydrolase"
                     /name="serine hydrolase"
     gene            8070..8231
                     /locus_tag="JJ182_28155"
     CDS             8070..8231
                     /locus_tag="JJ182_28155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166328.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="UMD00039.1"
                     /translation="MAKFIQNQSLLLLEKLNELDLDVEADLCEKLHDDAEHLFRTLSSR
                     LDELQDGN"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            8231..8653
                     /locus_tag="JJ182_28160"
     CDS             8231..8653
                     /locus_tag="JJ182_28160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005229777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="UMD00040.1"
                     /translation="MARVSISEAARLVKVSRPTIYKMINSGKLSYTSVVKHGKAIKVID
                     TSELIRVFGSLDGVIDTVKYDVKSDAESTGVNSVGLHDLQHRIALLEAENDGLKGAVKA
                     RDEHIDSLRQAMQLLEHKHEPSSPPHSPWWKFWKKS"
                     /name="helix-turn-helix domain-containing protein"
     gene            9617..10186
                     /locus_tag="JJ182_28165"
     CDS             9617..10186
                     /locus_tag="JJ182_28165"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UMD00041.1"
                     /translation="MSSDDSKISTDAIGDVNEYLLSPTKGGALKVTIPDDLNDDLSAYA
                     AGYNTSKSEVVRNSVASFMGNDLRWTHRQYFFRPRRKLVSFEDLRMCTGFVQVACFPKD
                     LPRNASGVTVKLLKYEKNFSIITFDLGNGVVPHPPYPIQGGDIDLGPGSLVMPTVEQST
                     NIYTMNIIYYRINNDLIWGVCPAISN"
                     /name="hypothetical protein"
     gene            10247..10618
                     /locus_tag="JJ182_28170"
     CDS             10247..10618
                     /locus_tag="JJ182_28170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008086990.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system HigB family toxin"
                     /protein_id="UMD00029.1"
                     /translation="MRVVTARTITDAMTVHAQWKVGLKLWLDVFDKQSLIFESFSQLRD
                     VWLSKSGWNVDRIPCSLLKAESKKGPLDIYVFDIHKNQCRVVVWLNPKSGTFFVKDVCS
                     HAEYDRWWRGQTKSQRSKG"
                     /name="type II toxin-antitoxin system HigB family toxin"
     gene            10622..11089
                     /locus_tag="JJ182_28175"
     CDS             10622..11089
                     /locus_tag="JJ182_28175"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UMD00030.1"
                     /translation="MRKASLGSEGIGGLIENLPQMLHGFSEQLHSVSILMSACMEPVTD
                     DHDLQERMAIIDELYSCAEDIDHVAIKFADLVTDRVYEYEKKNRNVPNVSPSEALSYFI
                     KERGLRQADLKSVASQSIISELINGKRVMNIDQVKGFAAFFDVPVETFMGT"
                     /name="hypothetical protein"
     gene            complement(11826..13688)
                     /locus_tag="JJ182_28180"
                     /pseudo=""
     CDS             complement(11826..13688)
                     /locus_tag="JJ182_28180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032495017.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="Tn3-like element Tn3 family transposase"
                     /name="Tn3-like element Tn3 family transposase"
     gene            complement(13740..15455)
                     /gene="tnpR"
                     /locus_tag="JJ182_28185"
     CDS             complement(13740..15455)
                     /gene="tnpR"
                     /locus_tag="JJ182_28185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004152391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Tn3-like element Tn4401 family resolvase TnpR"
                     /protein_id="UMD00031.1"
                     /translation="MKTGQTTASSSTPVGFPDADSLAALRGWYAGLSSRAAVEHYLAAR
                     KAAGQSARGMLGHIRRQLIVFANSRHRPDLADVFQHAPEERQGRAGAVERAIRLLPTLP
                     APKPQISDSIDQWLSPRTVRALQAYGIHTLSALTVRIPRRRGWWKAIEGLGMTGARQVE
                     AFFAAHPQLTERARALIPIIQPSGIVPWEQLRLPNEVDGSQGNFRAPRNACTLNATNDY
                     EAVQAWLALHETVATQRAYRKEAARLILWAIVERGRALSSLTTDDAIAYRAFVRHPTPR
                     ERWVGPPRPRDSVEWRPFSGGLSARSAAYALTVLSALFRWLIEQRYVLANPFAGVKVRG
                     HALRPALDTARGFTEGEWLLLRAIADGLEWSYGWSEPAAQRLRFMLDFGYATGLRASEL
                     VGAVLGNVRLDEHGDHWLHLVGKGGKPGKVALPPLAYTALDQYLAQRQLPVSRERWNPK
                     TPLVGSLGEDGNAGITGPHLWCVLRRFFTQAAEAIEADHPVAAEKLRRATPHWMRHSHA
                     SHALARGAQLTAVRDNLRHASIATTSMYLHGDELERARQMRQAFGARHVKRGVD"
                     /name="tnpR"
     gene            15565..18594
                     /gene="tnpA"
                     /locus_tag="JJ182_28190"
     CDS             15565..18594
                     /gene="tnpA"
                     /locus_tag="JJ182_28190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004152392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Tn3-like element Tn4401 family transposase"
                     /protein_id="UMD00032.1"
                     /translation="MSKKNKLLSVLSDAEQEALYGLPEFDDAQQLEYLAVTETELALAN
                     SRPSLHAKVYCLLQIGYFKAKHAFFSFDWDEVEDDCAFVLSRYFHGEVFEPKAITKHER
                     YTQREQIAKLFGYWPWSAAFLPQLEQQAARTVRRDVTPGFVAAELIVWLNEHKIIRPGY
                     TTLQELVSETLSAERRRLGNLLEQALDESAKAALSQLLVRDDTLSQLAALKQDAKNFGW
                     RQMVREREKRATLEPLHAIAKTLLPKLDVSQQNLLYYASLANFYTVHDLRNLKADQTQL
                     YLLCYAWVRYRQLSDNLVDAMAYHMKQLEDESSAGAKQSFADEQVRRQQETPRVGRLLS
                     LYVDDSVADPTPFGEVRQRAYKIMPRDTLQTTAQRMSVKPASKLALQWQAVDGLADRMR
                     RHLRPLYVALDLSGSNPDSPWLAALAWAKGVFAKQQRLSQRPLDEWPAATLPKRLRPYL
                     LTFDADGKPTGLHADRYEFWLYRQIRKRLQSGELYLDDSLQHRHFSDELVEMDRKIDVL
                     AKMEIPFLQQPVHAQLDALTAELRTQWLAFNRELKQGKLTHLEYNKDTQKLTWRKPKSE
                     NEKAREKAFYEKLPFCDVADVFRFVNDECKFLSAFTPMQPRYAKKVADADSLMAVIIAQ
                     AMNHGNHVMARTSDIPYHVLDSGYQQYLRQATLHAANDCISNAIATLPIFPYYSFDLET
                     LYGAVDGQKFSVERPTVKARYSRKYFGRGKGVVAYTLLCNHIPLNGYLIGAHDYEAHHV
                     FDIWYRNTSDIMPTAITGDMHSVNKANFAILHWFGRRFEPRFTDLNAQLKELYCADDPA
                     QYQACLIRPVGKIDCDLIHREKPNIDRIVATLGLKEMTQGTLIRKLCTYTTTNPTRRAI
                     FEFDKLIRSIYTLRYLRDPQLERNVHRSQNRLESYHQLRSAIAQVGGKKELTGRTDIEI
                     EISNQCARLIANTIIFYNSAILSRLVTKYEAAGNSKALALITKISPAAWRHILLNGHYT
                     FQSSGKTIDLDAIVAGLELE"
                     /name="tnpA"
     ARG             1168..2045
                     /name="blaKPC-2"
                     /gene="blaKPC-2"
                     /gene_name="carbapenem-hydrolyzing class A beta-lactamase
                     KPC-2"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             6074..6624
                     /name="aac(6')-Ib"
                     /gene="aac(6')-Ib"
                     /gene_name="AAC(6')-Ib family aminoglycoside
                     6'-N-acetyltransferase"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             6710..6966
                     /name="aadA15"
                     /gene="aadA15"
                     /gene_name="ANT(3'')"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="97.14"
                     /coverage="32.32"
     ARG             6023..6627
                     /name="AAC(6')-Ib10"
                     /gene="AAC(6')-Ib10"
                     /gene_name="AAC(6')"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="98.97"
                     /coverage="99.01"
     Typing          complement(11245..11652)
                     /name="ColRNAI_rep_cluster_1987"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="94.377"
                     /coverage="99.0"
                     /evalue="1.26e-177"
ORIGIN
        1 atgaacctcc agcatgagcg gatcgacgcc ctgtgccagc aactcaaact cgaacgggtg
       61 gcaacgcatt accccgtcct ggcgcagcag gcggtgcgcg aggacttcag cttcaccgac
      121 ttcctggaac acctgttgcg gcatgaagcg gggtgtcgcc agcagcgcag ccgcgaactg
      181 ctgacgcgga tggcttgctt cccgggcatc aagaccctgg aggactatga cttcagcttc
      241 aaccccggcg tgcccaaggc actggtgcag gagctgggca gtctggcgtt tgtcgaacgg
      301 gccgagaacg tggtgctgat cggaccctct ggcatcggca agacccacct cgccatcgcc
      361 ttgggttaca aggccgcgca agccggggtc aagacacgct tcatcacggc agccgacctg
      421 atgctgcaac tgagcacggc gcagcgacaa gggcggctga aggaatactt caaccgcgcc
      481 atcctcggtc cacggctgct ggtgatcgat gagatcggct acctgccttt cggacgcgag
      541 gaagcgaacc tgttctttca ggtggtggcg aagcgctatg agaaaggggc gatgatcctg
      601 acctcgaacc tgccgttcag ccagtgggcc gacgcgtttg ccggcgatac caccctgaca
      661 gccgcgatgc tggatcggct gctgcaccat gcccatatcc tgaccctgag cggcgaaagc
      721 taccgcttga aggacaagag gaaggcggga gtggtcagga aaaattccaa acccgaatga
      781 tccaggtggg tcagtattac tttggtgatt caggggtaaa gtgggtcagt tttcagttgg
      841 tgttgacacc ggcgtaccct cggtgctatc ttcgcgcccc aatagtcggg gcttggccag
      901 gacttcctga ggccgtccgt aacgtggatg ccgaggtcag gcgaggtggc cgacccatga
      961 acgccgacct gattcgtttt tcaatagcgc tggacgttgt ggtgccaggg acttaccaac
     1021 ccgatgtgtg cccatccggg gcagttacag ccgttacagc ctctggagag ggagcggctt
     1081 gccgctcggt gataatccca gctgtagcgg cctgattaca tccggccgct acacctagct
     1141 ccaccttcaa acaaggaata tcgttgatgt cactgtatcg ccgtctagtt ctgctgtctt
     1201 gtctctcatg gccgctggct ggcttttctg ccaccgcgct gaccaacctc gtcgcggaac
     1261 cattcgctaa actcgaacag gactttggcg gctccatcgg tgtgtacgcg atggataccg
     1321 gctcaggcgc aactgtaagt taccgcgctg aggagcgctt cccactgtgc agctcattca
     1381 agggctttct tgctgccgct gtgctggctc gcagccagca gcaggccggc ttgctggaca
     1441 cacccatccg ttacggcaaa aatgcgctgg ttccgtggtc acccatctcg gaaaaatatc
     1501 tgacaacagg catgacggtg gcggagctgt ccgcggccgc cgtgcaatac agtgataacg
     1561 ccgccgccaa tttgttgctg aaggagttgg gcggcccggc cgggctgacg gccttcatgc
     1621 gctctatcgg cgataccacg ttccgtctgg accgctggga gctggagctg aactccgcca
     1681 tcccaggcga tgcgcgcgat acctcatcgc cgcgcgccgt gacggaaagc ttacaaaaac
     1741 tgacactggg ctctgcactg gctgcgccgc agcggcagca gtttgttgat tggctaaagg
     1801 gaaacacgac cggcaaccac cgcatccgcg cggcggtgcc ggcagactgg gcagtcggag
     1861 acaaaaccgg aacctgcgga gtgtatggca cggcaaatga ctatgccgtc gtctggccca
     1921 ctgggcgcgc acctattgtg ttggccgtct acacccgggc gcctaacaag gatgacaagc
     1981 acagcgaggc cgtcatcgcc gctgcggcta gactcgcgct cgagggattg ggcgtcaacg
     2041 ggcagtaagg ctctgaaaat catctattgg cccaccaccg ccgcccttgc gggcggcatg
     2101 gattaccaac cactgtcaca tttaggctag gagtctgcgc ggcagagccg tgtgaccggt
     2161 tttctgtaga gcactgacga tggcggcggc gctctctgca attggcaagg cgtcggcgcc
     2221 aaggatacca atcttgcggc gcgcggcgtg ttatgacgac tggggtgcat ttgagccgcc
     2281 ccatttaacc ttcgccctca cagatacgcc attcgcctca gatttagcgc catgcagacg
     2341 agcttccact cggcttgcac cttgtccagg cccctcatgc tgaactgacg caatcccatc
     2401 accgccttga tccaaccatt cggagcctcc acgatcgact tgcgccggcg gtaagctgca
     2461 tcgccttgct ccgttttcaa tttcgccgca atcgccgccg tatgcggatg ggtcttggca
     2521 ttgaccttgg catcttcacg tccctcgcgg ccgagggcaa cgatgacatc gccgtggtga
     2581 tcggcgacct ttgccagaac agcctcacta cggaatcccg catccgccag cgtctgggcc
     2641 ggcatttctc cggtgttggc ctgaactgct gccagcatgc ccagcagcgc ctgactgtcc
     2701 gcggcgcagt tggtcaactc cgccgccacg atgatctggt gctcggcatc gaccgctgtg
     2761 tacccgttgt agctctgctc ggagccacca ccggcgtgtt tcatgatccg gctgtccgga
     2821 tcggtgaagc tttcctgatc acggtcatcc ggcacaccaa actcgcgttt gtacgagcca
     2881 ccgcccttgt ccgagccatc cggatggcga ggccggcggc catcgtcttc gctgcgcccc
     2941 cgggcctggt ccgcttcacg ctggcgcgct tccaggcgcg cctttgccgc ctggatcgcc
     3001 tccaggcgct tctcgcggcg agaaatctcg gcaggaatgt ccagctccgg ctcgttacgc
     3061 tcctggtcgt cggtagcctt ggcgcgatca agcagcgcct tgatctcgca atgcaattcg
     3121 tcctcggccg gcttcatgcg cttatagctc atcgccttgt ggcggctggc gttggctttt
     3181 accttggtgc cgtcgaccgc gatcgtgcca agcttcacca gcccacattc gcgcgccagt
     3241 tgcaccacct gaacgaacaa attctcaagc tcggtcaggt gtagggcacg gaagtcactc
     3301 agcgtgcggt gggccgggaa gtttccagcg gccagcacac gcaacgcgac atcctcgtac
     3361 agcttcctgg ctagtttgcg cgaagagaag acgccgctcg cgtaaccata gatcagcact
     3421 ttgaccatca tcgccggatg aaacggctga ttgcccggac caccgccggc ataccgggcg
     3481 tggaatgcgc tcaagtccag cgtatcgaca gtctcgctga tgaagtaggc aagatgccct
     3541 tcaggtagcc actctcccag agaagggggc agcagatagg attggtcggg tcggtaagga
     3601 aggtaactgg cagccatccc cgtatcgtcc tcgatcttcc gccgatttgg cttctgccgc
     3661 gcaggctcct aggccaccgt agctaaacat acgagaaaaa ccgcttcttg agcgctctct
     3721 gagaccacct tgccgacaac gcagaaacgg ttgcggaaaa atcggcgttt ccggcgtacg
     3781 ccacccgacc tggacgaact attgcggacc tggaactgga gtagcggaat tccccggggt
     3841 ttcagcgtcg cgccacagcg cctcagatag atgcggtagc ctttggcggg tcgtcatgcc
     3901 gcggaccacc cccccaaaaa attccacaat gcggaatggc ggaattttct ggggttcccg
     3961 cttacccccc cttcatgaaa attatcgtct gagggccggg caatttcacg gacaagcgtg
     4021 atgatttcag ccagcttttg ccttgggatg tagctgaaca cctcagcacg aatcgattcg
     4081 tccggtgttt cttctttcag caggtacgaa catgcgctgg cgagcgccaa tgcagattta
     4141 tccagatcct tcagcgagcg gagccgtttt ttctgcccaa tctttctggc gtcacggatg
     4201 ataacggcca gcatggcgtc cagaacgtcc agtgcatcat ccagcgccag cgtttcccat
     4261 gcaaggacaa aggcaaccag aaccgccatc cttttctgcg gtgacatcct ggcaatattg
     4321 aacaccgaag tcataccagc ataacgtgcg agatttttca ggcgcacagc cgggagtgta
     4381 ctcaggtttt cagcatgcag gccaaaatcg ttcagagttt tccagcgttc aattgcttca
     4441 ttaaacgccg gaccactgat ggtcacaggg ccctttttca gtgattccag taaagacagg
     4501 cggctgcaat cagttggccc cagcagcatc tccagctgtg aacgctgttc ggctgacggt
     4561 atcagtgcca gtttgttcca caggcgcaac gtcgcctttt cccttacctc tgaaatcaac
     4621 cgggtcagcg tggtggctcc ggggagaata atacgatgtt gcataagcca ccctgtcgcc
     4681 aggtcgaaaa gcaggccagg acgttcgttg cttatccagc tccgggtata taaaagacgg
     4741 gtaaggcgaa atgtccaggg ccaggcaaat tcacgatact gatagtgctg acgtatcagc
     4801 gctgcatgct cacggcgggt attttccctc tgaccgtatt ctgcaagaac ggtgatatca
     4861 cgaatcccga gctgtctggc ggtaaaatgc cggacgccgg aaggaatatg attcatgtca
     4921 gtaagaaaag tgcccagaaa acgcacacac ccgatttgca gggcaatacc aagtcgattg
     4981 tgatcacccc ggcttttccc gataaattct ttatccgctt catcaagatg aaaataacgc
     5041 gccagctgaa gttcatcggg ttcgccagtg aacctgccat aactctcaac ctgctcagtg
     5101 gtcaaaaaat caacgggcat atcggcctcc ctgcctgacg gcttttttaa cacaactgca
     5161 accgttcgaa atattataaa ttatcagaca tagtaaaacg gcttcgtttg agtgtccatt
     5221 aaatcgtcat tttggcataa tagacacatc gtgtctgata ttcgatttaa ggtacatttt
     5281 tatgcgaatt tttggttatg cgcgggtctc aaccagccag cagtccctcg atattcagat
     5341 cagagcgctc aaagatgcag gggtaaaagc taaccgcatc tttaccgaca aggcatccgg
     5401 cagttcaaca gatcgggaag ggctggattt gctgaggatg aaggtggagg aaggtgatgt
     5461 cattctggtg aagaagctcg accgtcttgg ccgcgacacc gccgacatga tccaactgat
     5521 aaaagagttt gatgctcagg gtgtagcggt tcggtttatt gacgacggga tcagtaccga
     5581 cggtgatatg gggcaaatgg tggtcaccat cctgtcggct gtggcacagg ctgaacgccg
     5641 gaggatccta gagcgcacga atgagggccg acaggaagca aagctgaaag gaatcaaatt
     5701 tggccgcagg cgtaccgtgg acaggaacgt cgtgctgacg cttcatcaga agggcactgg
     5761 tgcaacggaa attgctcatc agctcagtat tgcccgctcc acggtttata aaattcttga
     5821 agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat aataatggtt
     5881 tcttagacgt caggtggcac ttttcgggga aaagtgcgcg gaacccctat ttgtttattt
     5941 ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa
     6001 taatattgaa aaaggaagag tatgagtatt caacatttcc aaacaaagtt aggcatcaca
     6061 aagtacagca tcgtgaccaa cagcaacgat tccgtcacac tgcgcctcat gactgagcat
     6121 gaccttgcga tgctctatga gtggctaaat cgatctcata tcgtcgagtg gtggggcgga
     6181 gaagaagcac gcccgacact tgctgacgta caggaacagt acttgccaag cgttttagcg
     6241 caagagtccg tcactccata cattgcaatg ctgaatggag agccgattgg gtatgcccag
     6301 tcgtacgttg ctcttggaag cggggacgga tggtgggaag aagaaaccga tccaggagta
     6361 cgcggaatag accagttact ggcgaatgca tcacaactgg gcaaaggctt gggaaccaag
     6421 ctggttcgag ctctggttga gttgctgttc aatgatcccg aggtcaccaa gatccaaacg
     6481 gacccgtcgc cgagcaactt gcgagcgatc cgatgctacg agaaagcggg gtttgagagg
     6541 caaggtaccg taaccacccc agatggtcca gccgtgtaca tggttcaaac acgccaggca
     6601 ttcgagcgaa cacgcagtgt tgcctaaccc ttccatcgag ggggacgtcc aagggctggc
     6661 gcccttggcc gcccctcatg tcaaacgtta aacatcatga gggaagcggt gatcgccgaa
     6721 gtatcgactc aactatcaga ggtagttggc gtcatcgagc gccatctcga accgacgttg
     6781 ctggccgtac atttgtacgg ctccgcagtg gatggcggcc tgaagccaca cagtgatatt
     6841 gatttgctgg ttacggtgac cgtaaggctt gatgaaacaa cgcggcgagc tttgatcaac
     6901 gaccttttgg aaacggcact gttgcaaata gtcggtggtg ataaacttat catccccttt
     6961 tgctgatgga gctgcacatg aacccattca aaggccggca ttttcagcgt gacatcattc
     7021 tgtgggccgt acgctggtac tgcaaatacg gcatcagtta ccgtgagctg caggagatgc
     7081 tggctgaacg cggagtgaat gtcgatcact ccacgattta ccgctgggtt cagcgttatg
     7141 cgcctgaaat ggaaaaacgg ctgcgctggt actggcgtaa cccttccgat ctttgcccgt
     7201 ggcacatgga tgaaacctac gtgaaggtca atggccgctg ggcgtatctg taccgggccg
     7261 tcgacagccg gggccgcact gtcgattttt atctctcctc ccgtcgtaac agcaaagctg
     7321 cataccggtt tctgggtaaa atcctcaaca acgtgaagaa gtggcagatc ccgcgattca
     7381 tcaacacgga taaagcgccc gcctatggtc gcgcgcttgc tctgctcaaa cgcgaaggcc
     7441 ggtgcccgtc tgacgttgaa caccgacaga ttaagtaccg gaacaacgtg attgaatgcg
     7501 atcatggcaa actgaaacgg ataatcggcg ccacgctggg atttaaatcc atgaagacgg
     7561 cttacgccac catcaaaggt attgaggtga tgcgtgcact acgcaaaggc caggcctcag
     7621 cattttatta tggtgatccc ctgggcgaaa tgcgcctggt aagcagagtt tttgaaatgt
     7681 aaggcctttg aataagacaa aaggctgcct catcgctaac tttgcaacag tgccctgata
     7741 aatctggagc cggtgagcgt gggtctcgcg gtatcattgc agcactgggg ccagatggta
     7801 agccctcccg tatcgtagtt atctacacga cggggagtca ggcaactatg gatgaacgaa
     7861 atagacagat cgctgagata ggtgcctcac tgattaagca ttggtaactg tcagaccaag
     7921 tttactcata tatactttag attgatttaa aacttcattt ttaatttaaa aggatctagg
     7981 tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt tcgttccact
     8041 gagcgtcaga ccccaaaaca gcgctgaaca tggctaaatt catccagaat cagtctctgc
     8101 tcttgttgga gaagcttaac gagcttgatc tcgatgtcga ggccgacctt tgtgagaaac
     8161 tccacgatga tgcggagcat cttttccgta cactgtcctc gagactggat gaattacagg
     8221 atggtaactg atggccagag tgtctattag tgaagcggca cggcttgtta aggttagtcg
     8281 ccccacaatt tacaagatga ttaacagtgg gaagttaagt tacacctctg ttgtaaagca
     8341 cgggaaggct attaaagtta ttgatacttc agagcttatt agagtgtttg gctctcttga
     8401 tggtgtcatc gatactgtaa aatatgatgt aaaaagtgac gcagaatcta caggtgttaa
     8461 cagcgttggt ttacatgatt tacaacatag aatcgcttta ctagaagctg aaaacgatgg
     8521 tcttaaaggg gctgttaagg ctcgagatga gcatattgat tcccttcgtc aagctatgca
     8581 gcttctggag cacaagcacg agccttcttc accaccccat tccccgtggt ggaaattctg
     8641 gaaaaaatcc tgaccccgtc atgcttcagt tttcctctcc ggccattccg gggagttcct
     8701 gaaccttcca aaaaatcgcc agatctctga acgctcctca ccactaaaaa tacccacaca
     8761 ctacgcaaaa ttaaaatttt gcagattcct tatttaaaac aatttgttaa tgaaaaatta
     8821 atgtgcagtg atgtgttaca aagtgcagat ccaagtcgtg gacgactcta tggcgaatcg
     8881 tttacgaatt gcccacgatt catatgtgaa tcacgcttta ttatcatgtt gttatgatga
     8941 atcgactctt gattcaattc atcaatttgg gcgtttttgt tcatggtgac tcttgattca
     9001 attcacgatt cgaatcgccg gtgaatcgtg tggtgagtcg tccggcgact tgccataacg
     9061 tgattgccgg ccgtcgacga acccgattcc tgaacgtgct gaaaaccggt tttccggctg
     9121 cgccggcaac gcctcacggc cacgcaataa attgcgtccc cgttcaccgt tttcggatca
     9181 gaagaacgcc ggaaacagga cttaccctgg ctgaatggcg tgaatttccg cgctatgcac
     9241 ttgcgcgcat actcatgcat gccgtaaaaa cagagcctgc gcgtttctgg cgggttttcg
     9301 ggtggtttgt tgcctgtttt accggtttcc cgtcagaaac gccctgaggc cgttttagcg
     9361 gtgcgtacaa tcagggcttt atgttaaata ataatcgtaa aatgccattg aaggggctaa
     9421 agggactttc tgctgaggga ctaagcggct ggcttcttgg cgacctttcc tcagaccctt
     9481 tcgtgaccat tttattcagt tcagttttat atggatgtga ttagttgaat tattctttta
     9541 tgatctttaa agtgtttaca tgtggactaa aaagttccac tatgtgtccg ttcttgttct
     9601 ttttgcgggg tggtatatgt ctagcgatga ttcaaaaatt tctaccgatg ccatcgggga
     9661 tgtaaatgaa tatcttttat ctccgactaa agggggggcg ttgaaggtaa ccatccctga
     9721 tgatctaaat gatgacttat cagcctacgc agctggttac aacacatcaa agtctgaagt
     9781 agtgaggaat agcgtagcta gtttcatggg gaacgatcta cgctggactc atcggcaata
     9841 ctttttccga ccacgtagga aattagttag ttttgaagat cttagaatgt gtactggctt
     9901 tgttcaagtc gcttgttttc caaaagatct tccaaggaat gcctctggag ttacagttaa
     9961 gttacttaaa tatgagaaaa atttttcgat tataactttt gatcttggaa atggtgttgt
    10021 acctcaccca ccctatccga ttcagggggg ggatatcgat ctcggacctg gttctttagt
    10081 tatgcccacc gtagaacaga gtaccaatat ctatacaatg aacattatat attacagaat
    10141 aaacaatgac ttaatctggg gtgtgtgtcc agcgattagt aattgaataa atttaaatcg
    10201 ctttattttg caaatatcgc aaattgcgat attatagggg taggttatgc gcgttgttac
    10261 ggctagaact atcactgatg ctatgactgt tcatgcccag tggaaagttg gactcaaatt
    10321 atggcttgat gtctttgata agcaatcttt gatttttgag tcattttctc aacttcggga
    10381 tgtttggctt agtaaatcag gatggaatgt cgatcgcata ccttgtagcc tgttaaaggc
    10441 agaaagtaag aaggggcctc ttgatatata tgtttttgat atacacaaga atcaatgcag
    10501 agttgttgtc tggttgaacc ctaagtctgg tacttttttt gtcaaagatg tttgttctca
    10561 tgccgaatat gatcgatggt ggagggggca aactaaatct caaaggtcaa aagggtgaat
    10621 tatgagaaaa gcatcactcg gttctgaagg aattggtggg ctcatcgaaa atttaccgca
    10681 gatgttacat ggtttttctg aacagttgca ttcagtgtct atcttaatgt ctgcatgtat
    10741 ggagccagtc accgatgatc atgacctcca agaacgtatg gcgattattg atgaattgta
    10801 ttcttgtgca gaagatatcg atcatgtcgc tataaaattt gccgatcttg taaccgatcg
    10861 agtctatgag tacgagaaga aaaatcgtaa cgttcctaac gtcagcccca gtgaggcgtt
    10921 gtcttatttc ataaaggaac gggggcttcg acaagctgac cttaaatctg ttgctagtca
    10981 gagcatcata tctgaactca tcaatggaaa aagggttatg aacatagatc aggtgaaagg
    11041 atttgctgcg ttttttgatg ttcctgtgga aacgtttatg gggacataaa aaaaaccacc
    11101 gttggtagcg gtggtttttt taggttcgtt gagctagcaa ctcataaaac ctgcggtaac
    11161 gagcttggag gagcttagtc accaaattgg tcctttcagt ttagctttaa ttgatgcata
    11221 acttcaagac taactcctct aaatcagtta ccagtggctg ctgccagtgg cgcttttgca
    11281 tgtcttaccg ggttggactc aagacgatag ttaccggaga aggcgcagcg gtcggactga
    11341 acggggggtt cgtgcataca gtccagcttg gagcgaactg cctacccgga actgagtgtc
    11401 aggcgtggaa tgagacaaac gcggccataa cagcggaatg acaccggtaa accgaaaggc
    11461 aggaacagga gagcgcacga gggagccatc agggggaaac gcctggtatc tttatagtcc
    11521 tgtcgggttt cgccaccact gatttgagcg tcagattccg tgatgctcgt caggggggcg
    11581 gagcctatgg aaaaacggcc gccgtgcggc ctttccttct ctccatcata cgattgctcg
    11641 gttttctcga gcgtttctac gcatgctcct gccgctcgcc gcagccgaac ggcaggagcg
    11701 tagctactga gtgagcgagg aagcggaaaa gagacctgtc tgacattgag cactgacgct
    11761 ctgaggccct ttatgaggaa agaacagaaa acggggtctg acgctcagtg gaacgaaaac
    11821 tcacgttaag caacgttttc tgcctctgac gcctctttta atggtctcag atgacctttg
    11881 gtcaccagtt ctgccagcgt gaaggaataa tggccgagca tattgatatg tccgtggcaa
    11941 agcggggaga ggcgtgcgat atcttcatca ttcagtgttt caccctgcgc ccggagatga
    12001 tccagagctg cctgcatata aatagtgttc cataacacga cggcgttagt gaccagcccc
    12061 agagctccca actgatcttc ctgaccgtcg gtatatcgtt ttcttatctc acctttttga
    12121 ccgtgacaga tggctctggc aactgcatga cggctttctc cccgattaag ctgggtcaga
    12181 atgcgccggc ggtaatcttc atcatcaata taattaagca gatacagcgt tttgttgatg
    12241 cgccccactt caatgattgc ctgagtcagt ccggagggac gttcactttt cagcaatgaa
    12301 cggaccagca ctgaggcctg tactttgccc agcttcaggg agcctgcggt ccggatcatt
    12361 tcgtcccact gaaggactat ttttcgggga tctgattgcc ctctggcaat atcattcagc
    12421 acgccatagt cggcatcatg gtccattcgc cagaaaaccg aagcaccggc atcagccagg
    12481 cgtggagaaa actggtatcc cagcagccag aaaaggccaa agacaagatc gctggcacct
    12541 gccgtatcgg tcataatttc ggttggattc agcccggtct cctgttccag aaggccttcc
    12601 agcacaaaga tagagtccct cagcgtcccc ggtataacga tgccatgaaa gccggaatac
    12661 tgatcggaca caaagttgta ccaggtgatc cctctgttat taccaaagta tttgcggttc
    12721 ggtccggcat tgattgttct gactggcgta acaaagcgca ttccatctgc agatgccact
    12781 tctcctccac cccatatctg tgccagtggc agcgttgcct gaaaatcaac cagtctggca
    12841 ttagcgctgg tgatagtttc agcccgcaga tagttcgctt ttgtccagtt cagccggtgt
    12901 cgggtcagtg caggaacatt tgatctgatc agtggttcca gaccgatatt gcaggcttca
    12961 gccatcagca cggcgctgat gctgacgggc agatcatcaa ctctggcact ggcttcactg
    13021 gcatggaaaa actcatcagc aaatccggta tgggcgttaa tttcgagcag caactccgtt
    13081 aaatccaccg gagggagcag atcactgatc attttgctca gtcgtttcag actgtccggc
    13141 tcatcaagac tggcgagggg agaaattgtc aaccggggct tcgggccaga aacatcgagt
    13201 tcgacagcct cattttcgcc aagacgtgca gcaacctgtc tgtaacgact atcaagctga
    13261 tggcccagag attttattgc ttcctgcggg tctgtcgggt gccccaaaga acgataaacc
    13321 ttaatccggt ttgcctgcca gtcagcaccc tgtagtaatc ttgcacgagg atctccccac
    13381 cggttactgc cggtaacgta gacatccctc cgcctcagac tatcctgcag tttactgaga
    13441 aagcagagcg tgtatcccct gcgggtgata tgtttttcct tgttaatcac cagccgtttc
    13501 catgaccgac tgataatttc cgttggtgcg tcgtcaaaaa actgccgccg tgagctgaac
    13561 tcccggctga ggtagtcaca ggcattcaga gtggtaaccc cggcaggtgc ggatgaaaat
    13621 ttaacggtat tcagcagatg gggcaggaaa cgacgaacgc gcccgtactg ctccaccatt
    13681 tcttcatggg gttctaagcg ggaatcccag aaaattccgt cattccgtat gatgaaaatt
    13741 cagtcgactc ctcgcttgac gtgacgagcg ccaaaagcct gccgcatctg cctggcgcgc
    13801 tcgagctcat cgccatgcaa atacatcgac gtcgtggcga tcgacgcatg gcgtaggttg
    13861 tcgcgcaccg cggtgagctg agctccccgg gccaacgcat ggctggcatg actgtgacgc
    13921 atccaatgag gcgtggcacg gcgcagcttt tcggcggcga ccggatgatc ggcctcaatg
    13981 gcctcagcgg cttgcgtaaa gaatcttcgc aacacgcacc aaaggtgagg gccggtgatg
    14041 ccggcattac cgtcttcccc aagactgccc accaggggcg ttttcggatt ccaccgttcc
    14101 cggctgactg gcagttgacg ctgtgccaag tattggtcca gcgccgtata cgcgagcggc
    14161 ggcaaggcca ccttacctgg tttgccacct ttgccaacca aatgcagcca gtggtcaccg
    14221 tgctcgtcga ggcggacatt acccaggacg gcgccgacca gttcgctagc gcgcaggccc
    14281 gtggcatagc cgaagtcgag catgaagcgc aggcgttgtg ctgccggctc ggaccagccg
    14341 taggaccatt ccaggccgtc tgcaatggcg cgcagcagta gccattctcc ctcggtaaag
    14401 cctcgcgccg tatccagtgc gggccgcaag gcgtgaccgc gtaccttgac gccggcgaaa
    14461 gggttggcca gcacatagcg ctgctcgatg agccaccgga acagcgccga gagcaccgtc
    14521 agcgcatacg ctgccgagcg tgcggacaag ccgcccgaga aggggcgcca ttccaccgaa
    14581 tcgcgtggtc gaggtggccc cacccaacgc tcgcgcgggg tcgggtgccg gacaaaggcc
    14641 cggtacgcga ttgcatcgtc cgtggtcagg gatgatagcg cccgtccgcg ttcgacgatg
    14701 gcccacagga ttagccgcgc agcctccttg cgataggcgc gctgtgtggc gacagtctcg
    14761 tgcagcgcca gccaggcctg cacggcctcg tagtcgttgg tcgcattcag cgtgcaagcg
    14821 ttgcgcgggg cccggaaatt gccctgcgag ccgtcgactt cgttcggcag acgcaactgc
    14881 tcccacggca cgatgccgct gggctgaata atcgggatca gggcccgggc gcgctcggtg
    14941 agctgcggat gtgcggcaaa gaaagcctcg acctgccggg cgcctgtcat gccgagtccc
    15001 tcgatggctt tccaccagcc acgccggcgg ggaatgcgca cggtcagcgc cgagagggtg
    15061 tggataccgt acgcctgcag tgccctgacg gtcctcggag acagccactg gtcgatgctg
    15121 tcgctgatct ggggcttcgg cgccggcagc gtgggcaaga gccggatcgc gcgttcgacg
    15181 gcacccgcgc gcccctgtcg ctcttcgggg gcgtgctgga acacgtcggc cagatccggc
    15241 cggtggcggc tgttggcgaa aacgatgagc tggcggcgga tatgccccag catccctcgc
    15301 gctgattgac cggcggcctt gcgtgccgcc aggtagtgtt caacggccgc gcgagagctg
    15361 agtcccgcgt accagccgcg caaggcagcc agcgaatccg catcgggaaa gccgactggg
    15421 gtagaactcg aagccgtagt ctggcccgtt ttcatatgga caggttgcga ttcgaaaagc
    15481 gagtaacgcg ataataacga ttatttcagt agaatcgaaa atgccccatg tttctacgaa
    15541 acctcaagat agcaagaacg ggccatgagc aagaagaaca agctactcag cgtcctatcc
    15601 gacgccgaac aggaggcctt gtatggcctg ccggagttcg atgatgcgca gcagctggaa
    15661 tatctggctg tgacagaaac cgagttggcg cttgccaaca gccggcccag tcttcatgcc
    15721 aaggtctatt gcctcttgca gatcggctac ttcaaggcca agcatgcctt cttcagtttc
    15781 gactgggacg aagtcgagga cgattgcgct ttcgtgctga gccgctattt ccacggcgag
    15841 gtgttcgaac ccaaggcgat caccaagcat gaacgctaca cccagcgcga gcagatcgcc
    15901 aaactattcg gctactggcc gtggtcggcc gccttcctgc cgcagctcga gcagcaggcc
    15961 gcacggaccg tgcggcgtga cgtaacgccg gggttcgtcg ccgccgagct gatcgtctgg
    16021 ctcaatgagc acaagattat ccggcccggc tatacgacct tgcaagagtt ggtcagcgaa
    16081 acgctatccg ccgagcgccg gcgcctgggc aatctgctgg agcaagcgtt ggacgaatct
    16141 gccaaggccg cgctgagcca gcttctggtc cgtgatgaca ccctgtcgca actggcggcg
    16201 ctcaagcagg acgccaagaa tttcggctgg cgccagatgg tccgcgagcg cgaaaagcgc
    16261 gccacgctgg agccgctgca cgcaatcgcc aagacactgc tgcctaaact cgacgtctcg
    16321 cagcagaacc tgctgtacta cgcgagcctg gcaaacttct acaccgtcca cgacctgcgc
    16381 aatctgaagg ccgatcagac ccaactctac ctgctgtgct atgcctgggt acgctaccgg
    16441 cagctctccg acaacctggt cgatgcgatg gcgtaccaca tgaagcagtt ggaggacgaa
    16501 agcagcgctg gtgccaaaca atcctttgcc gacgagcagg tgcgccgtca gcaggaaacg
    16561 ccgcgggtag gccgcctgct gtcactctac gttgatgata gcgtggccga tcccacgccc
    16621 ttcggcgagg tgcggcagcg cgcctacaag atcatgcctc gcgatacgct gcaaaccacg
    16681 gcgcagcgta tgagcgtgaa gccggcgagc aagctggcct tgcagtggca ggcggtggac
    16741 gggctggccg accgcatgcg ccgccatctt cgtccactgt acgttgcgct cgacctctcc
    16801 ggctccaatc cagacagtcc atggcttgcc gcgctggcct gggccaaagg tgtttttgcc
    16861 aagcagcagc ggctgtcgca acggccactc gacgagtggc ccgcggcgac acttccgaaa
    16921 cgcttgcggc cgtacctgct gaccttcgac gccgacggta aaccaaccgg cctgcacgct
    16981 gaccgctacg agttctggct gtaccgccag atcaggaagc gtctccaatc gggtgaactc
    17041 tacctcgacg acagcctgca acaccggcac ttctcagatg aactggttga gatggacagg
    17101 aagatcgatg tgctcgcaaa aatggagatc cccttcctgc agcaacccgt ccatgcccaa
    17161 ctcgatgcgc tgactgccga actgcgcacg cagtggctgg cgttcaaccg cgagctgaaa
    17221 cagggcaagc tgacgcacct cgaatacaac aaggacacgc agaaactgac ctggcgcaag
    17281 cccaagagcg agaatgagaa agcgcgcgaa aaggcattct acgagaagct tccgttctgc
    17341 gacgtggccg acgtgtttcg cttcgtcaac gacgagtgca agtttctgtc ggcgttcacg
    17401 cccatgcagc cgcgctacgc gaagaaggtc gccgacgctg acagcctgat ggcggtcatc
    17461 atcgcgcaag cgatgaacca cggcaaccac gtcatggcgc gcaccagcga catcccgtac
    17521 cacgtgctgg atagcggcta ccagcagtac ctgcgccagg caacgctgca cgcggccaac
    17581 gactgcatca gcaacgccat cgccacgcta ccgatcttcc catactactc gttcgacctc
    17641 gaaacgctgt acggtgccgt cgacgggcag aaattcagcg tcgaacggcc gaccgtgaag
    17701 gcgcgctatt cgcgcaagta cttcgggcgc ggcaagggcg tggtcgccta cacgctgctg
    17761 tgcaaccaca tcccgctcaa cggctacctg atcggcgcgc acgactacga ggcccaccac
    17821 gtgttcgaca tctggtatcg caacacgtcg gacatcatgc cgaccgcgat caccggcgac
    17881 atgcacagcg tcaacaaggc caacttcgcc atcctgcatt ggtttggccg gcggttcgag
    17941 ccgcgcttca ccgacctcaa cgcgcaattg aaagaactct actgcgctga cgatccagca
    18001 cagtatcagg cgtgcctgat tcggccagtc gggaaaatcg actgcgatct catccatcgc
    18061 gagaagccga acatcgaccg gatcgtcgcc acactcgggc tgaaggaaat gacgcagggc
    18121 acgctgatcc gcaagctgtg cacctacacc acgacgaacc cgacgcggcg cgcgatcttc
    18181 gagttcgaca agctcatccg cagcatctac acgcttcgct acctgcgcga tccgcaactg
    18241 gaacgcaacg tgcaccgctc gcaaaatcgc ctcgagtcct accatcagct acgctcggcc
    18301 attgcccagg tcggcggtaa gaaggaactg accggtcgca ccgacattga aatcgagatc
    18361 agcaaccagt gcgcacggct gatcgccaac acgatcattt tctacaactc ggcaatcttg
    18421 tcgcggctgg tgaccaagta cgaggcggcc ggcaacagca aggcgctggc actcatcaca
    18481 aaaatttcgc ctgcggcatg gcggcacatc ctgctcaacg ggcactacac ctttcaaagc
    18541 agcggcaaga cgatcgatct cgatgcgatc gtcgcaggcc tggaactgga gtgacggaat
    18601 tttcagcggt tccgtgttag cagcagtgta aaactgaccc accccagcga agtaaaactg
    18661 atccacctgg gctagtttgg cggccttttc gaggccgtcg atgttgaccc aggagcaaac
    18721 cgtggaaatc agagttcttg cccgacaggg ccactccatc cggcacatcg cccgcacgtt
    18781 gggggtctcg cgcaataccg tgcgccgcta cctccgcgat ccgtcggtag cgcgatacca
    18841 gccccgtgaa ccacgcccca ccaaactggg gccatttgaa tcttatctgc ggcaacgggt
    18901 cgagcaggcc caccccatct ggctgcctgc caccgtcctg aatcgggaaa tccgcgctca
    18961 agggtatggc ggcggtctct cgttattgcg cgccttcctc gccacgctca agcccgcccg
    19021 ccgcgaagca ggtccggccg tccgtttcga gaccgagccc ggacggcagt tgcaggctga
    19081 tttcgtggtc ttgcgccggg ccagatcccc catgtcggcc ttcgtcgcca cgctgggata
    19141 cagccgcatg acgtttgtca ccttcgtacc ggacgaatcc ttcgagtccg tgcgggactc
    19201 cctgttgctg gcttttgact atctgggcgg tgtgccccgc gaggtgttgt tcgacaacat
    19261 gaagaccgtg gtgctggaac gcgatgccta cggtgacggc aagcaccgtt ttcaccccgg
    19321 cttgcttcaa ctggccgatg acctggggtt ccggatccgg ctgtgtcgcc cgtatcgggc
    19381 ccagaccaaa ggcaaggtcg agcgcttcaa tcgctacttc cgcgagagct tctacaaccc
    19441 gttgctgacc cggatgaagg gcacggggct gctgctcgat tgtgctgctg ccaaccgacg
    19501 cgtccgtgac tggttggcag acgaggcgaa tgtgcgggtc cacgccaccc tgaacgagcg
    19561 ccccatcgac cgttggcggc aggagcggga acacctgcaa cccttgccat cccgtgtgcg
    19621 gcgcgacgag gcccccctgc tggataacag tctccgcccg gtaccactgg aatctctcca
    19681 gcacccactg tctgtctatg acgcaattgg ggaggcctgc cg
//
