LOCUS       CP063635               17115 bp    DNA     circular BCT 04-APR-2022
DEFINITION  Enterococcus faecium strain ICU-5-1 plasmid pZA5-1_02, complete
            sequence.
ACCESSION   CP063635
VERSION     CP063635.1
DBLINK      BioProject: PRJNA669626
            BioSample: SAMN16483151
KEYWORDS    .
SOURCE      Enterococcus faecium
  ORGANISM  Enterococcus faecium
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 17115)
  AUTHORS   Both,A., Kruse,F., Mirwald,N., Franke,G., Christner,M., Huang,J.,
            Hansen,J.L., Kroger,N., Berneking,L., Lellek,H., Aepfelbacher,M. and
            Rohde,H.
  TITLE     Population dynamics in colonizing vancomycin-resistant Enterococcus
            faecium isolated from immunosuppressed patients
  JOURNAL   J Glob Antimicrob Resist 28, 267-273 (2022)
   PUBMED   35134550
REFERENCE   2  (bases 1 to 17115)
  AUTHORS   Both,A., Kruse,F., Christner,M., Huang,J., Mirwald,N., Franke,G. and
            Rohde,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-OCT-2020) Institute of Medical Microbiology, Virology
            and Hygiene, University Medical Center Hamburg-Eppendorf,
            Martinistr. 52, Hamburg, Hamburg 20246, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. v0.4.7
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 124.1x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 10/27/2020 18:40:16
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.13
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 3,095
            CDSs (total)                      :: 3,004
            Genes (coding)                    :: 2,905
            CDSs (with protein)               :: 2,905
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 99
            CDSs (without protein)            :: 99
            Pseudo Genes (ambiguous residues) :: 0 of 99
            Pseudo Genes (frameshifted)       :: 35 of 99
            Pseudo Genes (incomplete)         :: 51 of 99
            Pseudo Genes (internal stop)      :: 25 of 99
            Pseudo Genes (multiple problems)  :: 10 of 99
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..17115
                     /organism="Enterococcus faecium"
                     /mol_type="genomic DNA"
                     /strain="ICU-5-1"
                     /isolation_source="rectal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1352"
                     /plasmid="pZA5-1_02"
                     /geo_loc_name="Germany: Hamburg"
                     /lat_lon="53.33 N 10.1 E"
                     /collection_date="2019-03-01"
                     /collected_by="Institute of Medical Microbiology, Virology
                     and Hygiene, University Medical Center Hamburg-Eppendorf"
     gene            join(17101..17115,1..849)
                     /locus_tag="IQN03_15185"
     CDS             join(17101..17115,1..849)
                     /locus_tag="IQN03_15185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010782381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zeta toxin family protein"
                     /protein_id="UOE17612.1"
                     /translation="MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSG
                     KTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELVKLYEKDVVKHVTPYSNRMTEALIS
                     RLSDQGYNLVIEGTGRTTDVPIQTATMLQSKGYETKIYVMAVPKIESYLGTIERYETMY
                     ADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISP
                     KETLERELNRKVSGKEIQPTLERIEQKMVQNQHQETPEFKAIQQKMESLQLPTPPIPKT
                     PKLPGI"
                     /name="zeta toxin family protein"
     gene            complement(1112..1849)
                     /gene="erm(B)"
                     /locus_tag="IQN03_15190"
     ARG             complement(1116..1849)
                     /name="erm(B)"
                     /gene="erm(B)"
                     /gene_name="23S rRNA (adenine(2058)-N(6))-methyltransferase
                     Erm(B)"
                     /tool="amrfinderplus"
                     /drug_class="LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(1974..2057)
                     /locus_tag="IQN03_15195"
     CDS             complement(1974..2057)
                     /locus_tag="IQN03_15195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001814874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA methyltransferase attenuation leader
                     peptide"
                     /protein_id="UOE17620.1"
                     /translation="MLVFQMRNVDKTSTVLKQTKNSDYADK"
                     /name="23S rRNA methyltransferase attenuation leader
                     peptide"
     gene            2204..2884
                     /locus_tag="IQN03_15200"
     CDS             2204..2884
                     /locus_tag="IQN03_15200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="UOE17614.1"
                     /translation="MNPFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            3517..4122
                     /locus_tag="IQN03_15205"
     CDS             3517..4122
                     /locus_tag="IQN03_15205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016176895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell filamentation protein"
                     /protein_id="UOE17615.1"
                     /translation="MILENKLGLTNQVELAKVEEKLSKQKAKELYDCGKINEIEVGTFK
                     GLSEIHEFLFSDIYDFAGKIRSVNIAKGNFRFAPVMYLEHSLQHIDQMPQTSFEEIIKK
                     YVEMNIAHPFREGNGRSTRIWLDLILKEELQKVVDWNLIDKADYLSAMERSPINDLEIR
                     YLISNALTDKIDDRELYMKGIDVSYFYEGYSEYTIDDL"
                     /name="cell filamentation protein"
     gene            4138..4710
                     /locus_tag="IQN03_15210"
     CDS             4138..4710
                     /locus_tag="IQN03_15210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000170424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="UOE17616.1"
                     /translation="MTKYGYARVSTASQSTKEQIQQLLENGVEKKNIFSEKFTGTKRDR
                     PKFNQLLAGLKPGDEIVVTKLDRFARNTREALEIIEPLLDDNVTIKVLNLGTIENTSMG
                     RMVTRTLLSVAEMERDMIVERTQEGKMFARKNNPNFREGRPKATITPKKRHAYELLTSG
                     KSYKEVEAITGFSRSTLFRIKKKIEES"
                     /name="recombinase family protein"
     gene            complement(4962..5219)
                     /locus_tag="IQN03_15215"
     CDS             complement(4962..5219)
                     /locus_tag="IQN03_15215"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOE17621.1"
                     /translation="MANLYIENKGDLNAIITLIVVMVKSIGNITIGMLFIILAAVLIFM
                     IVIWFLNERSKDNQHRRDMEIKSIESIDYLSIITLKKPRS"
                     /name="hypothetical protein"
     gene            complement(5345..6160)
                     /locus_tag="IQN03_15220"
     CDS             complement(5345..6160)
                     /locus_tag="IQN03_15220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002326780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOE17617.1"
                     /translation="MVKIAGLSKGGKTVSQLYKQNYRDWRQFRKNIKDSYFILPTELEK
                     YLPNNKAINLYLYYCFKAKNEGGDSWHSVNTIAESLGVTTKTINTWNKTLVDLGMIARI
                     DDNHLSKSTILLPLSSYYKLALDSSLKDVTESTVHEIDGNLVAVYHLFEWRKNEADENY
                     NVPYNTLCCVFKRKTQKDTIYKFILVQDEKISNFELSTPSSKIYDDAYRFECQDLEALL
                     SANNLNNIEHENFVVNTRFNLVSEKDSDLLDLLIELTKNLDKKENITVL"
                     /name="hypothetical protein"
     gene            6677..8002
                     /locus_tag="IQN03_15225"
     CDS             6677..8002
                     /locus_tag="IQN03_15225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002335330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Y-family DNA polymerase"
                     /protein_id="UOE17618.1"
                     /translation="MMDYSKEPVNDYFLIDMKSFYASVECIERNLDPLTTELVVMSRAD
                     NTGSGLILASSPAAKKKYGISNVSRPRDLPQPFPKTLHVVPPRMNLYIKRNMQVNNIFR
                     RYVADEDLLIYSIDESILKVTRSMNLFTTEGTRSQRRKKLAQMIQENIKEELGLLATVG
                     VGDNPLLAKLALDNEAKHNDGFLAEWTYQNVPDKVWNIPEMTDLWGIGSRMKKRLNQIG
                     IMSIKDLANWNPYTIKSHLGVIGLQLYFHANGIDRTDIAIPPEPTKEKSYGNSQVLPRD
                     YTRRNEIELVVKEMAEQVAIRIRQHNCKTGCVHLYIGTSILETRPGFSHQMKIPITDNT
                     KELQNYCLFLFDKYYEGQEVRHVGITYSKLVYTDSLQLDLFSDPQKQIDEENLDKIIDK
                     IRQKYGFTSIVHASSMLEGARSITRSTLVGGHAGGAGGLKND"
                     /name="Y-family DNA polymerase"
     gene            7995..8345
                     /locus_tag="IQN03_15230"
     CDS             7995..8345
                     /locus_tag="IQN03_15230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002359653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOE17619.1"
                     /translation="MIDYNDRGRLKWAGFYLSDHTEKIDADNEQRANQNLAKEQMTTEE
                     VAEVLNAAVIKNRSVCIQKEERNAEGYYPEDIVSKILGSDELGIYVGKNKVHYDEIRHI
                     EFYQDNKWGRLE"
                     /name="hypothetical protein"
     gene            8327..8512
                     /locus_tag="IQN03_15235"
     CDS             8327..8512
                     /locus_tag="IQN03_15235"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOE17622.1"
                     /translation="MGSIRMNIIQQYELKYITFDQLSEEIWGYGQRLINEVGVERFSFY
                     VEAAAGYHKYEYYIGY"
                     /name="hypothetical protein"
     gene            complement(9416..9691)
                     /locus_tag="IQN03_15240"
     CDS             complement(9416..9691)
                     /locus_tag="IQN03_15240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001196543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type III secretion system protein PrgO"
                     /protein_id="UOE17603.1"
                     /translation="MALLPTNKDKKKIGAEDISIKDDINVELGERKYTAKERKPVQVDP
                     PVLKTIRDLSYAKDIPMYEIVKLAMDAYVDTLNDEERIIYNRRSKD"
                     /name="type III secretion system protein PrgO"
     gene            complement(9663..10616)
                     /locus_tag="IQN03_15245"
     CDS             complement(9663..10616)
                     /locus_tag="IQN03_15245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016623100.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family protein"
                     /protein_id="UOE17604.1"
                     /translation="MENLRTAFKTSDKLGKVVMLTGRKGGIGKTTDNDLLAIVSSQLFE
                     KDVLLIDYDQQRNTTSNIGSTYQITSFDRSMSAAIKKGDWVSGITQVSPHLYIMAGSPG
                     SEELNEYLSEKYPDRRKRSLAFIKPLEELRKNFDYIFIDCPPSTDNVVRAFLTAADYII
                     AMQELKRYAMEGTEDFINKVLVPIVTNFEESHLQIIGILPVLFSVRRSSQHANYQKTID
                     KYGESNIFKSIVKGSDRLEMYGENGIQLNDYVDRRWWAIFADIFTELEERIEYYEQHGD
                     IEGFDYTPKYADSMANHILPLGKEIKLNGIITNEQR"
                     /name="ParA family protein"
     gene            11228..12721
                     /locus_tag="IQN03_15250"
     CDS             11228..12721
                     /locus_tag="IQN03_15250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000947690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primase C-terminal domain-containing protein"
                     /protein_id="UOE17605.1"
                     /translation="MLSEIYSAILKNGLRTYKYRNSTMKPAGHIDSSRSGAIFAYRSKQ
                     LMNVGRGMVITSEEAILENEKKLTHWTPNTYRFGTYADDYRTVVKGHSEKNLSQINTFV
                     VDIDSKENHQGEIILACLDQVGYMPTLILESDHGYQVYFVLKTPGYVTKKSNFKVIDVA
                     KKISKTIRLQLAEKLSGVDLGCNHFGIARFPQENNIVFKEMNYQYSFADWIQWSMKLES
                     DQKTKEDRERKLIVFPEKKEIRQVDEPWFDMLLHKANIVGGEGRLGRNNVIFTLSLAYY
                     SSGYALDTCEYNMFTFNERLQEPLSEAELVKIVRSAYSGNYQAASREFIIELCQQWVSP
                     TLKNNDLFIQRRGWWKFKKPRDQRKYSHKNEWKEDLLAYLSEKSLASEPYLNLSKKELA
                     SQLTMPKRTLDKILNELREENKVFYKVTRGRNGGMIIASVKTLFARVIQLSKEKRLDYS
                     TRITEVFGLNESLVEETFRQLSTPLNPLKEVNLFEVDTG"
                     /name="primase C-terminal domain-containing protein"
     gene            12856..13152
                     /locus_tag="IQN03_15255"
     CDS             12856..13152
                     /locus_tag="IQN03_15255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000053907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type III secretion system protein PrgN"
                     /protein_id="UOE17606.1"
                     /translation="MSLKNYVYSHPVNVFIIGRLGLSVEVFCELYGFKQGTLSSWVTRE
                     KTVASLPIEFLHGLSLASGETMDQVYDCLCVLEQEYIEYKIANELRKRKKYIQ"
                     /name="type III secretion system protein PrgN"
     gene            13253..14104
                     /locus_tag="IQN03_15260"
     CDS             13253..14104
                     /locus_tag="IQN03_15260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002354342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOE17607.1"
                     /translation="MKSDDWIEHTWLPLKRNSKRKKFWVLQLWPLGKLCSYGARLILDL
                     TVYSIGVFGTAYYLINDPNRIAASDIFTVLMTLIFVMLLSIFTQLVMQFTRQKLTAGKL
                     FKSLFDLIVVNAILATLIKQIEQSGRTTKGVKDFLLTFIHFVNGHMYLFEVGIILFFVG
                     YVSTKLIKRSIEKEIEIDLIPTLLGYEYNVDFGRYDELINTDIVHTSIHESTVKGIRSI
                     LKNGQEMKAIDRRKEIYNFYEVEASLRYGIGKLWLDGSNIRQNKPYIFWNSSDLELPMK
                     DK"
                     /name="hypothetical protein"
     gene            14125..14408
                     /locus_tag="IQN03_15265"
                     /pseudo=""
     CDS             14125..14408
                     /locus_tag="IQN03_15265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002345737.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            14770..15450
                     /locus_tag="IQN03_15270"
     CDS             14770..15450
                     /locus_tag="IQN03_15270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="UOE17608.1"
                     /translation="MNPFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            15606..16502
                     /locus_tag="IQN03_15275"
     CDS             15606..16502
                     /locus_tag="IQN03_15275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002355409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family protein"
                     /protein_id="UOE17609.1"
                     /translation="MIQYYYTKKEWGVVMEKEKLKILEELRRILNNKNEAIIILNNYFK
                     GGVGKSKLSTMFAYLTDKLNLKVLMIDKDLQATLTKDLAKTFEVELPRVNFYEGLKNGN
                     LASSIIHLTDNLDLIPGTFDLMLLPKLTRSWTFENESRLLATLLAPLKSDYDLIIIDTV
                     PTPSVYTNNAIVASDYVMIPLQAEEESTNNIQNYISYLIDLQEQFNPGLDMIGFVPYLV
                     DTDSATIKSNLEELYKEHKEDNLVFRNIIKRSNKVSTWSKNGITEHKGYDKKVLSMYEN
                     VFFEMIERIIQLENEKE"
                     /name="ParA family protein"
     gene            16601..16810
                     /locus_tag="IQN03_15280"
     CDS             16601..16810
                     /locus_tag="IQN03_15280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000527318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-binding protein"
                     /protein_id="UOE17610.1"
                     /translation="MGNLGAQKAKRNDTPISAKKDIMGDKTVRVRADLHHIIKIETAKN
                     GGNVKEVMDQALEEYIRKYLPDKL"
                     /name="peptide-binding protein"
     gene            16827..17099
                     /locus_tag="IQN03_15285"
     CDS             16827..17099
                     /locus_tag="IQN03_15285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002333002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antitoxin"
                     /protein_id="UOE17611.1"
                     /translation="MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVN
                     LLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYSKQILNKEKVA"
                     /name="antitoxin"
     ARG             complement(1113..1849)
                     /name="ErmB"
                     /gene="ErmB"
                     /gene_name="Erm 23S ribosomal RNA methyltransferase"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; lincosamide antibiotic;
                     streptogramin antibiotic; streptogramin A antibiotic;
                     streptogramin B antibiotic"
                     /identity="98.37"
                     /coverage="98.79"
     Typing          11229..12721
                     /name="rep_cluster_185"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.866"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 gacttcaccg aaaagcaatt tgaagatcgt ttagaaaaga atgttgaacg actaactaaa
       61 aatagactag cggttgaatc gccaaccgct tttttacttg gtgggcaacc agggtcaggg
      121 aaaaccagtt tgcgatcagc aatttttgaa gaaacacaag ggaatgttat tgtcattgat
      181 aatgatacct ttaaacaaca gcacccaaat tttgacgaat tagtgaaact ctatgaaaaa
      241 gacgtagtaa aacacgttac cccttattcg aatcgcatga cagaagcact tattagccgt
      301 ttaagcgatc aaggctataa tttagtgatt gaaggaacag gacgaacaac agacgttccc
      361 attcaaacag ccacaatgct tcaatctaaa ggttatgaaa caaaaatata cgtcatggca
      421 gtaccgaaaa ttgaatcata cttaggaacg attgaacgat atgaaaccat gtatgcagat
      481 gatccaatga cagctagggc aacaccaaaa caagcgcatg atattgttgt caaaaactta
      541 ccgaccaatt tagaaaccct tcataaaacg ggcttattta gcgatataag gctttacaat
      601 agagaaggag tgaaactcta ttcaagctta gaaacgcctt ccattagtcc gaaagagacc
      661 ttagaaagag aattaaatcg taaagtatca gggaaagaaa ttcaaccgac tttggagaga
      721 atagagcaaa aaatggttca aaatcaacac caagaaaccc ctgaatttaa agcaattcaa
      781 caaaaaatgg aaagcttgca gctacctaca ccaccaatac ccaaaacacc taaacttcca
      841 ggtatttaaa ccttaaaaaa ggaaaagagt agttaccaaa aaacggtaac tactcttttt
      901 ttataaaaac atttcctcat gttggggtcc cgagcgccta cgaggaattt gtatcgataa
      961 gaaatagatt taaaaatttc gctgtttttt tctaatttca ttttgaggtg aattaattgg
     1021 tagttattag aggtgcccta tacctaataa tttatctaca ttccctttag taacgtgtaa
     1081 ctttccaaat ttacaaaagc gactcataga attatttcct cccgttaaat aatagataac
     1141 tattaaaaat agacaatact tgctcataag taacggtact taaattgttt actttggcgt
     1201 gtttcattgc ttgatgaaac tgatttttag taaacagttg acgatattct cgattgaccc
     1261 attttgaaac aaagtacgta tatagcttcc aatatttatc tggaacatct gtggtatggc
     1321 gggtaagttt tattaagaca ctgtttactt ttggtttagg atgaaagcat tccgctggca
     1381 gcttaagcaa ttgctgaatc gagacttgag tgtgcaagag caaccctagt gttcggtgaa
     1441 tatccaaggt acgcttgtag aatccttctt caacaatcag atagatgtca gacgcatggc
     1501 tttcaaaaac cactttttta ataatttgtg tgcttaaatg gtaaggaata ttcccaacaa
     1561 ttttatacct ctgtttgtta gggaattgaa actgtagaat atcttggtga attaaagtga
     1621 cacgagtgtt cagttttaat ttttctgacg ataagttgaa tagatgactg tctaattcaa
     1681 tagacgttac ctgtttactt attttagcca gtttcgtcgt taaatgccct ttacctgttc
     1741 caatttcgta aacggtatcg gtttctttta aattcaattg ttttattatt tggttgagta
     1801 ctttttcact cgttaaaaag ttttgagaat attttatatt tttgttcatg taatcactcc
     1861 tgaagtgatt acatctataa ataaatacag aagttaaacg atttgtttgt aattttagtt
     1921 atctgtttaa aaagtcataa gattagtcac tggtaggaat taatctaacg tatttattta
     1981 tctgcgtaat cactgttttt agtctgtttc aaaacggtag atgttttatc tacattacgc
     2041 atttggaata ccaacatgac gaatccctcc ttcttaatta caaattttta gcatctaatt
     2101 taacttcaat tcctattata caaaattttg gttctgttgc aaagttttaa atctactatc
     2161 aaataaggta gaataataga aaaagatagc aggaggaatg acgatgaatc cttttaaagg
     2221 aaagcaattt cagcaggatg tgattattgt agccgtgggc tactatcttc gttataacct
     2281 tagctatcgt gaagttcaag aaatcttata tgatcgtggc attaacgttt ctcatacgac
     2341 gatttatcgt tgggtgcaag aatatggcaa actactctat caaatttgga aaaagaaaaa
     2401 taaaaaatcc ttttattcat ggaaaatgga tgaaacgtac atcaaaatta aaggaaaatg
     2461 gcattatttg tatcgagcca tcgatgcaga tggtttaacc ttggatattt ggttacgtaa
     2521 aaaacgggac acacaagcag cctatgcttt tcttaagcgg ttagtgaagc agtttgatga
     2581 accgaaggtt gtagtcacag ataaagcccc ctctattaca agtgccttta agaaactaaa
     2641 agaatacggc ttttatcaag ggacagaaca tcgtaccatt aaatacctga ataatttgat
     2701 tgaacaagac catcgtccag taaagagacg caataaattc tatcgaagtt tacgcactgc
     2761 ctctaccacg attaaaggca tggaagccat tcgaggatta tataagaaaa cccgaaaaga
     2821 aggcactctc ttcgggtttt cggtctgtac tgaaatcaag gtattattgg gaatcccagc
     2881 ttaaatcata gataccgtaa gggattttat tctttattta aaactttgca acagaaccct
     2941 atttattagg aatggctctt gcttatagtg ttggttcttt gataaaggta aacgtgtcac
     3001 ttgatctatt tactatttta ctagcggttg gggtatcttc ggttattgga ctggtctttt
     3061 ctgtaatgcc cgcttcagag gctgcaaaaa aagatttaat tgatattctt agataaaatc
     3121 agaatgacaa gaatatttac gttctagatt ctaaaataaa acacaaagag accaaccagg
     3181 caccctattg tttctttgta gtatagagat attctttggc ttgtaagaga tcaatagagt
     3241 taggtgaccg gagttcgaaa taaaggaaat ttttgattgt ataggagaat tctttatccc
     3301 taatatttag aattttgagt atgccatgtt gatgttttag attctctata aatatagagg
     3361 tgtatcaaag gtcaactaga ctgtgcaaaa tagagacact tgaaaaatct atcgggggtc
     3421 agaaacttaa tagtttttga cacataaaca aaatcgcgat ataatggggt tgagagtgtt
     3481 tcataaactt atgtcataaa gttaaggaga tttcgcatga ttttagagaa taaattggga
     3541 ttaaccaatc aagttgagtt ggctaaggtt gaagaaaaac tcagtaaaca aaaagcgaaa
     3601 gaattgtacg attgtggaaa aataaatgaa atcgaagttg gtacatttaa aggtttatct
     3661 gaaattcatg aatttctatt ttcggatatt tacgattttg ccggaaaaat ccgatcggtc
     3721 aatattgcaa aaggaaattt tcgatttgca ccagttatgt atttagaaca ttcgttacag
     3781 catattgatc agatgccaca aacttctttt gaagagatta tcaagaaata tgtggagatg
     3841 aatatcgctc acccatttcg agaaggaaat ggccgaagta ctagaatttg gctggatctc
     3901 attttaaagg aagaattgca aaaagttgta gattggaact taatcgataa agcagactat
     3961 ctttctgcaa tggagcgaag tcccataaac gatttggaaa tacgctatct aatttccaat
     4021 gctctgactg ataaaattga cgatcgcgag ttatatatga aaggaatcga tgtcagctat
     4081 ttctatgaag ggtattctga gtatacgata gatgatttgt aaaagtaggt ggaccaaatg
     4141 acgaaatatg gatatgcacg tgtctcaacc gcttctcaaa gtacaaaaga acaaattcaa
     4201 cagttgcttg agaacggcgt agagaagaag aatatttttt cagaaaaatt tacgggtaca
     4261 aaacgggatc ggccaaaatt caatcagctg ttggctggtc tgaagcctgg agatgaaata
     4321 gttgttacga agcttgatcg atttgctcgt aacacgagag aagcattaga gatcattgaa
     4381 cctttactcg atgataacgt aacgatcaag gttttgaatc taggaacgat tgaaaatacg
     4441 tccatggggc gaatggtgac acggacgttg ttgagtgtag cagaaatgga acgtgatatg
     4501 attgtggaac gtacccaaga aggaaaaatg tttgcaagaa agaataatcc taatttcaga
     4561 gaaggacgtc cgaaagcaac aatcacaccg aagaagaggc acgcatatga actgcttact
     4621 tcaggtaaat cgtataagga agttgaagct ataaccggtt tcagtcgcag tacgcttttt
     4681 agaataaaga agaaaattga agaaagttaa aaaagaagtc tcagcgaacc agacaggtaa
     4741 atacttaatg cgttctagat atgagtctat tagcatgttg tgaaatataa tattttttta
     4801 tttacttgat ttctgctcaa aaaatgtgta tggtaactgt aaaaggtaaa gtaattaaag
     4861 gtatgctagc cacgcttact atattaggat accatcatat atttataatg aacgatttgt
     4921 tcgtctacca aacaacacat atcgttcagc gtaagtcacg tttaggaacg tggctttttt
     4981 agtgttatta tcgataaata atctattgac tctattgatt ttatctccat atccctacgg
     5041 tgttgattgt ctttagatct ttcatttaag aaccaaataa ctatcataaa aatcagcact
     5101 gctgctaata taataaacag cattcctatt gtgatattac ctattgattt taccataact
     5161 acgattaaag taataatggc attcaagtct cctttgttct ctatatataa attagccata
     5221 aatcatcttc ctttcaaatt aagatacttg tttgatacca ataaatagta agcgtggcta
     5281 gcataccttt ttctgtaata gcaagtgttc taatagtcca aacttaatga tggaccgatg
     5341 ctagttatag tacagtaatg ttttctttct tatctagatt tttagtaagc tctatcagca
     5401 aatctaacaa atctgagtcc ttttcagaaa ctaaattaaa tctagtgttt acaacaaagt
     5461 tttcatgttc tatattgttt agattatttg cggaaaggag ggcttctaga tcttgacatt
     5521 caaatctata tgcatcgtca taaatcttac tagaaggagt gcttaattcg aaattactta
     5581 ttttctcatc ttggaccaag ataaatttat agatagtatc tttttgtgtt tttcttttaa
     5641 aaacacaaca gagtgtgtta taaggaacgt tataattttc atcagcctca ttttttctcc
     5701 attcaaacaa atgataaact gcaaccaagt tgccatcaat ttcatggaca gtgctctcgg
     5761 taacatcctt taaagaacta tcaagggcta atttatagta actagagaga ggaagtaaaa
     5821 ttgtcgattt actgagatgg ttatcgtcta tacgtgcaat catacctaaa tcaactaagg
     5881 ttttattcca ggtgtttata gttttagttg tcactcctag agactctgct atggtattga
     5941 ccgaatgcca ggaatccccg ccttcattct ttgccttaaa acagtaatac agatataaat
     6001 taatagcttt gttattcggt aaatattttt caagttctgt tggtagaata aagtaagaat
     6061 ccttaatgtt ttttctgaac tgtctccagt ctctgtagtt ttgtttataa agttgtgaaa
     6121 cggtttttcc acctttagaa agtcctgcta tcttaaccaa tcttattgct cctttcttga
     6181 atctgtcatg atcatacagt attttttact tgtagtccag caccttaata tattatccta
     6241 tgtaattaat ttcgtactag atagtaatta ttttttattt aattctctag tcacttacaa
     6301 ataagttata taaactacga ttaataaatt attacaaaaa ctattaagaa aacttctaca
     6361 tacaactatt acaaaactat taagaaactg aatactccta ttttttgttt ttaaggaaag
     6421 ttttttcttt tttgaatttc ttattttttt ctaatataac taagcaaaac tggataatac
     6481 gacacttatt ttcaaatttt cacaagacta atagtaaata tccatttaat aaagtgatac
     6541 aatgtgttga ttttacaaat caacagaaga agtagggaaa taacttacct atgcttcttt
     6601 ttttgtacat ttaatcgatt cttctttaca aaaacgaacg tatgtttgta taatgtggaa
     6661 gaatggagtg ttatttatga tggattattc aaaagagcca gtaaatgatt actttttgat
     6721 cgatatgaaa agcttttacg caagtgtcga atgtatagaa aggaatttag atccattaac
     6781 gactgaatta gtcgtcatga gtcgagcgga taatacagga tcagggttga ttttagcttc
     6841 ttcaccagct gcaaagaaga agtacggtat ttctaatgtc agtcgaccac gagatctacc
     6901 gcaacctttt cctaaaacgt tacatgtcgt tccaccacgc atgaatctct atattaagcg
     6961 aaatatgcag gtaaacaata ttttcagaag gtatgtagca gacgaagatt tattgattta
     7021 ctcgatcgat gaatcgatct taaaagtgac cagatcaatg aatcttttta cgactgaagg
     7081 aacaagaagt caacggagaa agaagctggc tcaaatgatc caggagaata ttaaagaaga
     7141 gctaggattg cttgctacag taggtgtcgg agataatccc ttattagcta aacttgcttt
     7201 agacaatgaa gcaaaacata atgatggatt ccttgctgaa tggacgtatc aaaatgttcc
     7261 tgataaagta tggaatattc ctgaaatgac agacctttgg ggtattggat ctcgaatgaa
     7321 aaaaagactc aaccaaattg gtatcatgag tattaaagac ttagctaatt ggaatccata
     7381 cactattaag agccatttag gtgtgattgg cttacagctg tattttcatg cgaacgggat
     7441 cgatcgaaca gatatagcga tcccaccaga accgacaaag gaaaaatcat atggtaattc
     7501 acaagtgtta ccacgagatt ataccaggag aaatgaaatc gaactggtgg taaaagaaat
     7561 ggcggaacaa gtagctattc gtatcaggca acataactgt aaaacaggtt gtgtccattt
     7621 atacattggc acgtcgatct tagaaacgag accaggtttt tcacaccaga tgaagatccc
     7681 tataacagat aatacaaagg aattgcagaa ttactgtctt ttcttgtttg ataagtatta
     7741 tgaaggacaa gaagtaaggc acgttggaat aacctatagc aagcttgtgt acactgattc
     7801 gcttcagctg gatttattta gtgatccaca aaagcaaatt gacgaagaaa atttagataa
     7861 aattattgac aagattcggc aaaaatatgg ttttacgtcg attgtacatg cttcttctat
     7921 gttagaaggc gctcgtagta ttactagaag tacattggtt ggtggccatg caggcggcgc
     7981 aggagggctt aaaaatgatt gattataatg atcgtggacg tttaaagtgg gcaggttttt
     8041 atttatctga tcatactgaa aaaattgatg ccgacaatga acaacgagcc aatcaaaatt
     8101 tggcaaaaga acaaatgacg actgaagagg ttgcggaagt attgaacgct gcagtcataa
     8161 aaaatagatc agtatgtatt caaaaagaag aacgaaacgc tgaaggatac tatccagaag
     8221 atattgttag caagatctta ggtagtgatg agctggggat ctacgttgga aaaaacaaag
     8281 ttcactacga cgaaatacgt catatcgaat tttaccagga taataaatgg ggtcgattag
     8341 aatgaacatt atccagcaat atgagctaaa gtatataacc tttgatcagc tatcagaaga
     8401 gatttggggt tatggccagc gtttgataaa tgaggttggt gttgaacgct tctctttcta
     8461 tgtagaagct gcagcaggat accataaata cgaatactat attggctatt aaagtgcaat
     8521 aaaattatat ttcttttatg ttttacattt tgtatcaatt ctgataaaat tacctatagg
     8581 taattaaaaa atataaaaaa actagttaca accttaggac gttgtaacta gcttgaagca
     8641 tactagagct aactaaaata gcactagaaa gcaatgttaa acccgtccaa caaacttgat
     8701 ttaacattga gaccagctta ttcagctaaa tatagttgaa taagcttctt ttgttttaaa
     8761 aaaacaaaag gtgtactacg aataacgcaa gtaaaagaaa tactattaca accagtaggc
     8821 tacaagtaag tattactaaa cattgcgtag ttagaacctt tgctctattg tctaaagcca
     8881 caaaattaga gatcagcttt atgatgctaa gagcgagctg catccatgcg gacataggtt
     8941 cttttgacac tattaattct cctttttagg ataagggaaa ttgctagtag ttttttcatt
     9001 agcaccatcc cccttcattt gattgagtct agtgctgctg tgatagtttg ctgtttaata
     9061 tgcttacatt cttattataa cataaatgaa acaaacacat ggttagaggt cgtatcaatc
     9121 aaaatagtgt ctcacaaacg atttattact tactcctgct gactaacgga ctgttcttca
     9181 gtaactgtaa ctatatgttt gttaaaacca ccattacctg tagataaaaa ccaatatatt
     9241 tactatactc actatattaa atatatttag tatagtaaaa actagaaaca ataaaatttg
     9301 tgaatgttgt atacccccaa acaatacaca tattttgaag gattaggatt aataaagcta
     9361 aaaatatagt aagtatacta aatatattta ctatatctag tatacttact atattttaat
     9421 cttttgatcg tctattatat ataatccgtt cctcgtcgtt taaagtatca acataggcgt
     9481 ccattgcaag tttgactatt tcatacatag gaatatcttt tgcataacta agatcccgaa
     9541 tggtttttag tacgggagga tctacttgaa ctggttttct ttctttcgca gtgtactttc
     9601 gttcccctaa ctcgacatta atatcatctt taattgaaat atcttcagca ccaattttct
     9661 tcttatcttt gttcgttggt aataatgcca tttagtttaa tctcctttcc aagaggtagg
     9721 atatgattgg ccattgagtc agcatattta ggtgtataat caaatccttc aatatcacca
     9781 tgttgttcat agtattcaat tctttcttct aattctgtaa agatgtctgc aaaaatagcc
     9841 caccatcttc gatctacata atcatttaat tggataccat tctcaccata catttctaac
     9901 cgatccgagc ctttaacaat gcttttaaaa atgtttgatt caccatactt atcaattgtt
     9961 ttttgatagt ttgcgtgttg agaggaacgt cgcactgaga aaagaacagg caaaattcca
    10021 atgatttgaa gatgagactc ttcaaaattc gtgacaatcg gaactaaaac tttattaata
    10081 aaatcttctg ttccttccat tgcgtaccgt tttaattctt gcattgcaat aatataatct
    10141 gcagcagtta agaatgcacg aaccacatta tctgttgatg gtgggcagtc gataaagata
    10201 taatcgaaat tttttctcaa ttcttctaaa ggtttaatga aggccaatga tctcttacga
    10261 cgatcaggat atttttcgga caagtattca ttaagttctt cagatccagg agagccagcc
    10321 ataatatata aatgtggact tacttgagta atacctgaaa cccagtcccc ttttttgatt
    10381 gctgcagaca tggatcgatc aaagctagta atttgatacg ttgatccaat gttggaagta
    10441 gtatttcttt gttggtcata atcaattagc aacacgtctt tttcaaaaag ttgactagaa
    10501 acaatcgcta ataaatcatt gtctgtagtc ttaccaatgc cgccttttct acctgtaagc
    10561 attacaactt ttcctagttt atctgatgtt ttaaatgcag tccgtaagtt ttccatagtt
    10621 ccctccaatt tcctatacta aatatattta gtatacttca tatacttaat atattcgata
    10681 tatctaatat actccaaatt gataagaatt cagactttat aaggaatata gtggatatac
    10741 taaatatatt tgctatattc agtatatcag atatattcaa aatgtcaaaa tatatttgtg
    10801 cgttttgcgt tgacaattta gagtgaaaag aggtaaactt aattctatag aaaccacaga
    10861 taattcacta tttacaaagt agcaaaagca gtggtactct ttaaacagaa aaattacata
    10921 aaaaaaagag acggaaataa ttgattttag cagaatcaat tatttctgaa tcacatggtt
    10981 aggacatgtg ttcacgctcg tctcaagaat atgtaagtag ctaccaacta cttatattaa
    11041 aagttgatcg gatacctttt ccgattgcct ttattctacc aaaaaaaggc gagcaactca
    11101 acagaagaac gtttatttag tgtacttaaa ttaaatattc ttaaacactg aagagagaac
    11161 acatactatg gctgagatta aagctaaact gtgttctctt tttgtttgag aaaggacgtt
    11221 acaatcgatg ttgagcgaaa tttattcagc tattcttaaa aacggcttac gtacatacaa
    11281 atatcgaaac agcaccatga aacctgcagg tcatattgat tccagtagga gtggtgctat
    11341 ctttgcgtac cgtagcaagc aattaatgaa tgttgggcgt ggtatggtca ttacttcgga
    11401 agaagctatt ttagagaacg aaaagaaact aacgcattgg acacctaata cctatcgctt
    11461 tggtacttat gcggatgatt atcgaacagt ggttaaaggt cattctgaga aaaacttaag
    11521 tcaaatcaac acatttgtag ttgatatcga ttcaaaagag aaccatcaag gcgaaattat
    11581 tttagcctgt ttagatcaag tgggctacat gccaacgcta attttagaat cagatcatgg
    11641 ttatcaagtt tattttgtac taaagacacc aggctatgtc acaaagaaaa gcaatttcaa
    11701 ggtgatcgat gtagcaaaaa aaatttcaaa aacaattcgt ctacagttgg ctgaaaaatt
    11761 gtccggagtg gatctaggat gtaaccactt cggaattgct cgattcccac aagaaaataa
    11821 tattgttttt aaagaaatga actatcagta ttcttttgct gactggattc aatggtcgat
    11881 gaagcttgaa tcagatcaaa aaacaaaaga agatcgagaa cgaaaactaa ttgtctttcc
    11941 tgagaaaaaa gaaattcgtc aagtagatga accgtggttc gatatgttac ttcataaagc
    12001 aaacatcgtc ggcggagaag gacgtcttgg tcgaaataat gtgattttca cgctttcttt
    12061 agcttattac tcttcaggtt atgcattgga tacttgcgaa tacaatatgt tcacattcaa
    12121 cgaacggtta caggaaccgc tatctgaagc agaattagta aagattgtac gtagtgctta
    12181 ttctggtaat tatcaagcag caagcagaga attcattatt gaattgtgcc agcaatgggt
    12241 ttcaccaacc ttaaaaaata atgatctgtt cattcaacga cgtggctggt ggaaatttaa
    12301 aaagccacga gatcaaagaa aatatagtca taaaaatgaa tggaaagaag atctattggc
    12361 ttatctaagc gaaaaaagtc ttgctagtga gccttatttg aacctgtcaa aaaaagaatt
    12421 ggcttcacaa ctaacgatgc ccaagcgaac acttgataag atcttaaatg agttacgaga
    12481 ggagaataaa gtcttctaca aggtaacacg aggaagaaat ggcggaatga tcattgcttc
    12541 agtcaaaacg ttgttcgcga gggttattca actaagtaaa gaaaagagac tagattattc
    12601 aacaaggatc acagaggtat ttggactcaa cgagagctta gtagaagaga catttagaca
    12661 attatcaacc cccttgaacc ctcttaaaga agtgaatctt tttgaagtag atacaggttg
    12721 aaaaataaaa ggtgcaaatt gccttataca atatatctat gatacttctg taggtgttgc
    12781 tccctttgcc tagctacgtg taggtggtat acttataact gcgtatgcag tcttatgtat
    12841 catggaggaa gttgtatgtc gttaaaaaat tatgtctatt cacatcctgt taatgtgttt
    12901 atcattggtc gtttgggatt atctgtggaa gtgttctgtg agctttatgg ttttaagcag
    12961 gggactttgt cttcttgggt taccagggaa aaaacagttg cttctttgcc gattgagttt
    13021 cttcatgggt tgtccttagc ttctggggag actatggatc aggtatatga ttgtttgtgt
    13081 gtgttagagc aggagtatat tgagtataaa atagctaacg agttaagaaa aaggaagaag
    13141 tatatccagt agtagttttt atttacttaa aaaattggtt cattgagcaa cctatcgctg
    13201 ctaaagtagc aaaggaaaac gttaaaggaa agaatttagg gaagaaatcg aaatgaaatc
    13261 ggacgactgg attgaacaca cctggcttcc tctgaaaaga aatagcaaac gaaagaaatt
    13321 ttgggtattg caattatggc cattaggaaa actttgtagt tacggggcac gacttattct
    13381 tgatttaacc gtttactcga ttggagtatt tggaacggct tattacttga taaatgatcc
    13441 caataggatt gcagcatcag acatttttac agtgctaatg acgttgattt ttgtcatgct
    13501 attgtctatt tttactcaat tagtcatgca atttaccagg caaaaattaa cagcaggaaa
    13561 acttttcaaa agcctattcg atttaattgt tgtaaatgca attctagcga ctttaataaa
    13621 acaaattgaa caatctggaa gaacaacaaa aggagtgaag gattttttat tgacgtttat
    13681 tcactttgta aatggacaca tgtatttgtt tgaagtgggt attattctct tttttgtcgg
    13741 gtatgtatcc acgaaactta ttaaacgttc aattgaaaaa gaaattgaaa ttgacctgat
    13801 tccgacactt cttggttatg agtacaatgt tgattttgga agatatgacg aattgatcaa
    13861 tacggatatc gttcacacga gtatccatga atctactgtt aagggcatca gatctatttt
    13921 aaaaaatggc caggaaatga aagcaataga tcgaagaaaa gagatctaca atttttatga
    13981 agtcgaagca agcctacgat atggcatcgg aaaattgtgg ttagatggaa gtaatattcg
    14041 tcaaaacaaa ccatacattt tttggaacag tagtgattta gaacttccaa tgaaagataa
    14101 ataattatgg agaatcgttt gaaaatgatt cctctataca ggattgtgct tatagttggc
    14161 atggagttaa aaaccttaaa gaaggagcag ttattcaaag tgaaagaacg tcataatcag
    14221 ttactatgta gtaaaacggg tacgatgaac attgaatacc gaacagaata tttagaatta
    14281 acgaatcaaa ctgatttttt gttgattcga aagcaacaag agcaagaaaa aaattaatgg
    14341 ctacttatag ccaattgatt gatgaatggg aacaattcaa ggaatctaaa attccagaac
    14401 gtctctaaaa gcctttattt gtaaagagca taaggaaacg tgggaacact ttttaaaaaa
    14461 agtgttccaa taggctgtgc ctattacgtt tctcaaaaat aaatgtggga acaaaatatt
    14521 taaaaatagg atagtgaaag gatagtgaag gatagtaaaa ggagggtagt aggatagcaa
    14581 aaaggatagg ctccttttcg ctatcctttt taaattggag gaattaatat ggaagtaaga
    14641 ataagaaatg tggatgagaa aatcgtaaga gaaattgatc gaagatgtga cgaacggttc
    14701 tgttgcaaag ttttaaatct actatcaaat aaggtagaat aatagaaaaa gatagcagga
    14761 ggaatgacga tgaatccttt taaaggaaag caatttcagc aggatgtgat tattgtagcc
    14821 gtgggctact atcttcgtta taaccttagc tatcgtgaag ttcaagaaat cttatatgat
    14881 cgtggcatta acgtttctca tacgacgatt tatcgttggg tgcaagaata tggcaaacta
    14941 ctctatcaaa tttggaaaaa gaaaaataaa aaatcctttt attcatggaa aatggatgaa
    15001 acgtacatca aaattaaagg aaaatggcat tatttgtatc gagccatcga tgcagatggt
    15061 ttaaccttgg atatttggtt acgtaaaaaa cgggacacac aagcagccta tgcttttctt
    15121 aagcggttag tgaagcagtt tgatgaaccg aaggttgtag tcacagataa agccccctct
    15181 attacaagtg cctttaagaa actaaaagaa tacggctttt atcaaggaac agaacatcgt
    15241 accattaaat acctgaataa tttgattgaa caagaccatc gtccagtaaa gagacgcaat
    15301 aaattctatc gaagtttacg cactgcctct accacgatta aaggcatgga agccattcga
    15361 ggattatata agaaaacccg aaaagaaggc actctcttcg ggttttcggt ctgtactgaa
    15421 atcaaggtat tattgggaat cccagcttaa atcatagata ccgtaaggga ttttattctt
    15481 tatttaaaac tttgcaacag aacctataaa agccctttaa agagggcttt tatatattaa
    15541 tcacaaatca cttatcacaa atcacaagtg attaatcaca aatcacttgt gatttgtgat
    15601 tcttaatgat acaatattac tatacaaaaa aagaatgggg cgtagttatg gagaaggaaa
    15661 aactaaaaat acttgaagaa ttaagacgta ttttaaacaa taaaaatgaa gcaattatta
    15721 tcttgaataa ttactttaaa ggtggtgttg gaaagtccaa attatcgact atgtttgctt
    15781 acttgacaga caaattgaat ttaaaagttt taatgatcga taaggactta caggcaacat
    15841 tgacaaaaga cttagcaaaa acttttgagg tagaattgcc acgtgtcaat ttttatgaag
    15901 gcttgaaaaa tggaaacttg gcttcttcta ttattcattt gactgataat ttagacttga
    15961 tccctggcac gtttgatttg atgttactgc caaaattaac tcgctcatgg acgtttgaaa
    16021 atgaaagtag attgcttgct actcttttag cacctttaaa aagtgactat gatcttatta
    16081 ttattgatac tgtaccaacg ccaagcgttt atacaaataa tgcaatcgtg gcgagtgatt
    16141 acgttatgat ccctttacaa gcagaagaag aaagtacaaa caacattcaa aactatattt
    16201 cctatttgat tgatttgcaa gaacagttta accctggact agatatgatt ggttttgttc
    16261 cttatttagt tgatacggac agcgcaacga taaaatcaaa cctggaagaa ctgtacaaag
    16321 aacataaaga ggataatttg gttttccgaa atattatcaa gcgaagtaat aaagtaagta
    16381 cttggtctaa aaatggcatt acagaacaca aaggctatga caaaaaagtt ttgtctatgt
    16441 atgagaacgt attttttgaa atgattgagc gaatcattca attagaaaat gaaaaagaat
    16501 agaatcacaa atcacaagtg attaatcaca aatcacttgt gatttgtgat aggtgatgat
    16561 aaaataaata gtaagaagaa atagaaagaa gtgagcgatc gtgggaaatt taggcgcaca
    16621 gaaagcaaaa cgaaatgata cgccaatcag cgcaaaaaaa gatataatgg gggataagac
    16681 ggttcgtgtt cgtgccgact tgcaccatat cataaaaatc gaaacagcaa agaatggcgg
    16741 aaacgtaaaa gaagttatgg atcaagcctt agaagaatat atacggaaat atttacctga
    16801 caaactttaa aaggagtgaa aatgaaatgg cagttacgta tgaaaaaaca tttgaaattg
    16861 aaatcattaa tgagttatcg gcaagtgttt ataatcgggt attaaattat gttttgaatc
    16921 atgaactaga tactaaaaat actcgtttac tagaagtgaa tcttttaaat caattagaag
    16981 tggcacaaga agttgattta tttcaacaac catttgaaga attacaagct attcatgagt
    17041 attggcggtc aatgaatcaa tattcaaaac aaattttgaa taaagagaaa gtggcttaac
    17101 atggcgaata ttact
//
