LOCUS       CP063613               17094 bp    DNA     circular BCT 04-APR-2022
DEFINITION  Enterococcus faecium strain ICU-1-1 plasmid pZA1-1_02, complete
            sequence.
ACCESSION   CP063613
VERSION     CP063613.1
DBLINK      BioProject: PRJNA669626
            BioSample: SAMN16483154
KEYWORDS    .
SOURCE      Enterococcus faecium
  ORGANISM  Enterococcus faecium
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 17094)
  AUTHORS   Both,A., Kruse,F., Mirwald,N., Franke,G., Christner,M., Huang,J.,
            Hansen,J.L., Kroger,N., Berneking,L., Lellek,H., Aepfelbacher,M. and
            Rohde,H.
  TITLE     Population dynamics in colonizing vancomycin-resistant Enterococcus
            faecium isolated from immunosuppressed patients
  JOURNAL   J Glob Antimicrob Resist 28, 267-273 (2022)
   PUBMED   35134550
REFERENCE   2  (bases 1 to 17094)
  AUTHORS   Both,A., Kruse,F., Christner,M., Huang,J., Mirwald,N., Franke,G. and
            Rohde,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-OCT-2020) Institute of Medical Microbiology, Virology
            and Hygiene, University Medical Center Hamburg-Eppendorf,
            Martinistr. 52, Hamburg, Hamburg 20246, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. v0.4.7
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 85.9x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 10/27/2020 18:01:07
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.13
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 3,192
            CDSs (total)                      :: 3,099
            Genes (coding)                    :: 3,002
            CDSs (with protein)               :: 3,002
            Genes (RNA)                       :: 93
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 97
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 29 of 97
            Pseudo Genes (incomplete)         :: 58 of 97
            Pseudo Genes (internal stop)      :: 20 of 97
            Pseudo Genes (multiple problems)  :: 9 of 97
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..17094
                     /organism="Enterococcus faecium"
                     /mol_type="genomic DNA"
                     /strain="ICU-1-1"
                     /isolation_source="rectal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1352"
                     /plasmid="pZA1-1_02"
                     /geo_loc_name="Germany: Hamburg"
                     /lat_lon="53.33 N 10.1 E"
                     /collection_date="2019-03-01"
                     /collected_by="Institute of Medical Microbiology, Virology
                     and Hygiene, University Medical Center Hamburg-Eppendorf"
     gene            join(17089..17094,1..858)
                     /locus_tag="IQN06_15670"
     CDS             join(17089..17094,1..858)
                     /locus_tag="IQN06_15670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010782381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zeta toxin family protein"
                     /protein_id="UOC51470.1"
                     /translation="MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSG
                     KTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELVKLYEKDVVKHVTPYSNRMTEALIS
                     RLSDQGYNLVIEGTGRTTDVPIQTATMLQSKGYETKIYVMAVPKIESYLGTIERYETMY
                     ADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISP
                     KETLERELNRKVSGKEIQPTLERIEQKMVQNQHQETPEFKAIQQKMESLQLPTPPIPKT
                     PKLPGI"
                     /name="zeta toxin family protein"
     gene            complement(1121..1858)
                     /gene="erm(B)"
                     /locus_tag="IQN06_15675"
     ARG             complement(1125..1858)
                     /name="erm(B)"
                     /gene="erm(B)"
                     /gene_name="23S rRNA (adenine(2058)-N(6))-methyltransferase
                     Erm(B)"
                     /tool="amrfinderplus"
                     /drug_class="LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(1983..2066)
                     /locus_tag="IQN06_15680"
     CDS             complement(1983..2066)
                     /locus_tag="IQN06_15680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001814874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA methyltransferase attenuation leader
                     peptide"
                     /protein_id="UOC51479.1"
                     /translation="MLVFQMRNVDKTSTVLKQTKNSDYADK"
                     /name="23S rRNA methyltransferase attenuation leader
                     peptide"
     gene            2213..2893
                     /locus_tag="IQN06_15685"
     CDS             2213..2893
                     /locus_tag="IQN06_15685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="UOC51472.1"
                     /translation="MNPFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            3526..4131
                     /locus_tag="IQN06_15690"
     CDS             3526..4131
                     /locus_tag="IQN06_15690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016176895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell filamentation protein"
                     /protein_id="UOC51473.1"
                     /translation="MILENKLGLTNQVELAKVEEKLSKQKAKELYDCGKINEIEVGTFK
                     GLSEIHEFLFSDIYDFAGKIRSVNIAKGNFRFAPVMYLEHSLQHIDQMPQTSFEEIIKK
                     YVEMNIAHPFREGNGRSTRIWLDLILKEELQKVVDWNLIDKADYLSAMERSPINDLEIR
                     YLISNALTDKIDDRELYMKGIDVSYFYEGYSEYTIDDL"
                     /name="cell filamentation protein"
     gene            4147..4719
                     /locus_tag="IQN06_15695"
     CDS             4147..4719
                     /locus_tag="IQN06_15695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000170424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="UOC51474.1"
                     /translation="MTKYGYARVSTASQSTKEQIQQLLENGVEKKNIFSEKFTGTKRDR
                     PKFNQLLAGLKPGDEIVVTKLDRFARNTREALEIIEPLLDDNVTIKVLNLGTIENTSMG
                     RMVTRTLLSVAEMERDMIVERTQEGKMFARKNNPNFREGRPKATITPKKRHAYELLTSG
                     KSYKEVEAITGFSRSTLFRIKKKIEES"
                     /name="recombinase family protein"
     gene            complement(4971..5228)
                     /locus_tag="IQN06_15700"
     CDS             complement(4971..5228)
                     /locus_tag="IQN06_15700"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC51480.1"
                     /translation="MANLYIENKGDLNAIITLIVVMVKSIGNITIGMLFIILAAVLIFM
                     IVIWFLNERSKDNQHRRDMEIKSIESIDYLSIITLKKPRS"
                     /name="hypothetical protein"
     gene            complement(5354..6169)
                     /locus_tag="IQN06_15705"
     CDS             complement(5354..6169)
                     /locus_tag="IQN06_15705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002326780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC51475.1"
                     /translation="MVKIAGLSKGGKTVSQLYKQNYRDWRQFRKNIKDSYFILPTELEK
                     YLPNNKAINLYLYYCFKAKNEGGDSWHSVNTIAESLGVTTKTINTWNKTLVDLGMIARI
                     DDNHLSKSTILLPLSSYYKLALDSSLKDVTESTVHEIDGNLVAVYHLFEWRKNEADENY
                     NVPYNTLCCVFKRKTQKDTIYKFILVQDEKISNFELSTPSSKIYDDAYRFECQDLEALL
                     SANNLNNIEHENFVVNTRFNLVSEKDSDLLDLLIELTKNLDKKENITVL"
                     /name="hypothetical protein"
     gene            6686..8011
                     /locus_tag="IQN06_15710"
     CDS             6686..8011
                     /locus_tag="IQN06_15710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002335330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Y-family DNA polymerase"
                     /protein_id="UOC51476.1"
                     /translation="MMDYSKEPVNDYFLIDMKSFYASVECIERNLDPLTTELVVMSRAD
                     NTGSGLILASSPAAKKKYGISNVSRPRDLPQPFPKTLHVVPPRMNLYIKRNMQVNNIFR
                     RYVADEDLLIYSIDESILKVTRSMNLFTTEGTRSQRRKKLAQMIQENIKEELGLLATVG
                     VGDNPLLAKLALDNEAKHNDGFLAEWTYQNVPDKVWNIPEMTDLWGIGSRMKKRLNQIG
                     IMSIKDLANWNPYTIKSHLGVIGLQLYFHANGIDRTDIAIPPEPTKEKSYGNSQVLPRD
                     YTRRNEIELVVKEMAEQVAIRIRQHNCKTGCVHLYIGTSILETRPGFSHQMKIPITDNT
                     KELQNYCLFLFDKYYEGQEVRHVGITYSKLVYTDSLQLDLFSDPQKQIDEENLDKIIDK
                     IRQKYGFTSIVHASSMLEGARSITRSTLVGGHAGGAGGLKND"
                     /name="Y-family DNA polymerase"
     gene            8004..8354
                     /locus_tag="IQN06_15715"
     CDS             8004..8354
                     /locus_tag="IQN06_15715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002359653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC51477.1"
                     /translation="MIDYNDRGRLKWAGFYLSDHTEKIDADNEQRANQNLAKEQMTTEE
                     VAEVLNAAVIKNRSVCIQKEERNAEGYYPEDIVSKILGSDELGIYVGKNKVHYDEIRHI
                     EFYQDNKWGRLE"
                     /name="hypothetical protein"
     gene            8351..8521
                     /locus_tag="IQN06_15720"
     CDS             8351..8521
                     /locus_tag="IQN06_15720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001021554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC51478.1"
                     /translation="MNIIQQYELKYITFDQLSEEIWGYGQRLINEVGVERFSFYVEAAA
                     GYHKYEYYIGY"
                     /name="hypothetical protein"
     gene            complement(9425..9700)
                     /locus_tag="IQN06_15725"
     CDS             complement(9425..9700)
                     /locus_tag="IQN06_15725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001196543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type III secretion system protein PrgO"
                     /protein_id="UOC51461.1"
                     /translation="MALLPTNKDKKKIGAEDISIKDDINVELGERKYTAKERKPVQVDP
                     PVLKTIRDLSYAKDIPMYEIVKLAMDAYVDTLNDEERIIYNRRSKD"
                     /name="type III secretion system protein PrgO"
     gene            complement(9672..10625)
                     /locus_tag="IQN06_15730"
     CDS             complement(9672..10625)
                     /locus_tag="IQN06_15730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016623100.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family protein"
                     /protein_id="UOC51462.1"
                     /translation="MENLRTAFKTSDKLGKVVMLTGRKGGIGKTTDNDLLAIVSSQLFE
                     KDVLLIDYDQQRNTTSNIGSTYQITSFDRSMSAAIKKGDWVSGITQVSPHLYIMAGSPG
                     SEELNEYLSEKYPDRRKRSLAFIKPLEELRKNFDYIFIDCPPSTDNVVRAFLTAADYII
                     AMQELKRYAMEGTEDFINKVLVPIVTNFEESHLQIIGILPVLFSVRRSSQHANYQKTID
                     KYGESNIFKSIVKGSDRLEMYGENGIQLNDYVDRRWWAIFADIFTELEERIEYYEQHGD
                     IEGFDYTPKYADSMANHILPLGKEIKLNGIITNEQR"
                     /name="ParA family protein"
     gene            11237..12730
                     /locus_tag="IQN06_15735"
     CDS             11237..12730
                     /locus_tag="IQN06_15735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000947690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primase C-terminal domain-containing protein"
                     /protein_id="UOC51463.1"
                     /translation="MLSEIYSAILKNGLRTYKYRNSTMKPAGHIDSSRSGAIFAYRSKQ
                     LMNVGRGMVITSEEAILENEKKLTHWTPNTYRFGTYADDYRTVVKGHSEKNLSQINTFV
                     VDIDSKENHQGEIILACLDQVGYMPTLILESDHGYQVYFVLKTPGYVTKKSNFKVIDVA
                     KKISKTIRLQLAEKLSGVDLGCNHFGIARFPQENNIVFKEMNYQYSFADWIQWSMKLES
                     DQKTKEDRERKLIVFPEKKEIRQVDEPWFDMLLHKANIVGGEGRLGRNNVIFTLSLAYY
                     SSGYALDTCEYNMFTFNERLQEPLSEAELVKIVRSAYSGNYQAASREFIIELCQQWVSP
                     TLKNNDLFIQRRGWWKFKKPRDQRKYSHKNEWKEDLLAYLSEKSLASEPYLNLSKKELA
                     SQLTMPKRTLDKILNELREENKVFYKVTRGRNGGMIIASVKTLFARVIQLSKEKRLDYS
                     TRITEVFGLNESLVEETFRQLSTPLNPLKEVNLFEVDTG"
                     /name="primase C-terminal domain-containing protein"
     gene            12865..13161
                     /locus_tag="IQN06_15740"
     CDS             12865..13161
                     /locus_tag="IQN06_15740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000053907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type III secretion system protein PrgN"
                     /protein_id="UOC51464.1"
                     /translation="MSLKNYVYSHPVNVFIIGRLGLSVEVFCELYGFKQGTLSSWVTRE
                     KTVASLPIEFLHGLSLASGETMDQVYDCLCVLEQEYIEYKIANELRKRKKYIQ"
                     /name="type III secretion system protein PrgN"
     gene            13262..14113
                     /locus_tag="IQN06_15745"
     CDS             13262..14113
                     /locus_tag="IQN06_15745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002354342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC51465.1"
                     /translation="MKSDDWIEHTWLPLKRNSKRKKFWVLQLWPLGKLCSYGARLILDL
                     TVYSIGVFGTAYYLINDPNRIAASDIFTVLMTLIFVMLLSIFTQLVMQFTRQKLTAGKL
                     FKSLFDLIVVNAILATLIKQIEQSGRTTKGVKDFLLTFIHFVNGHMYLFEVGIILFFVG
                     YVSTKLIKRSIEKEIEIDLIPTLLGYEYNVDFGRYDELINTDIVHTSIHESTVKGIRSI
                     LKNGQEMKAIDRRKEIYNFYEVEASLRYGIGKLWLDGSNIRQNKPYIFWNSSDLELPMK
                     DK"
                     /name="hypothetical protein"
     gene            14134..14417
                     /locus_tag="IQN06_15750"
                     /pseudo=""
     CDS             14134..14417
                     /locus_tag="IQN06_15750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002345737.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            14779..15459
                     /locus_tag="IQN06_15755"
     CDS             14779..15459
                     /locus_tag="IQN06_15755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="UOC51466.1"
                     /translation="MNPFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            15615..16511
                     /locus_tag="IQN06_15760"
     CDS             15615..16511
                     /locus_tag="IQN06_15760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002355409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family protein"
                     /protein_id="UOC51467.1"
                     /translation="MIQYYYTKKEWGVVMEKEKLKILEELRRILNNKNEAIIILNNYFK
                     GGVGKSKLSTMFAYLTDKLNLKVLMIDKDLQATLTKDLAKTFEVELPRVNFYEGLKNGN
                     LASSIIHLTDNLDLIPGTFDLMLLPKLTRSWTFENESRLLATLLAPLKSDYDLIIIDTV
                     PTPSVYTNNAIVASDYVMIPLQAEEESTNNIQNYISYLIDLQEQFNPGLDMIGFVPYLV
                     DTDSATIKSNLEELYKEHKEDNLVFRNIIKRSNKVSTWSKNGITEHKGYDKKVLSMYEN
                     VFFEMIERIIQLENEKE"
                     /name="ParA family protein"
     gene            16589..16798
                     /locus_tag="IQN06_15765"
     CDS             16589..16798
                     /locus_tag="IQN06_15765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000527318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-binding protein"
                     /protein_id="UOC51468.1"
                     /translation="MGNLGAQKAKRNDTPISAKKDIMGDKTVRVRADLHHIIKIETAKN
                     GGNVKEVMDQALEEYIRKYLPDKL"
                     /name="peptide-binding protein"
     gene            16815..17087
                     /locus_tag="IQN06_15770"
     CDS             16815..17087
                     /locus_tag="IQN06_15770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002333002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antitoxin"
                     /protein_id="UOC51469.1"
                     /translation="MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVN
                     LLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYSKQILNKEKVA"
                     /name="antitoxin"
     ARG             complement(1122..1858)
                     /name="ErmB"
                     /gene="ErmB"
                     /gene_name="Erm 23S ribosomal RNA methyltransferase"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; lincosamide antibiotic;
                     streptogramin antibiotic; streptogramin A antibiotic;
                     streptogramin B antibiotic"
                     /identity="98.37"
                     /coverage="98.79"
     Typing          11238..12730
                     /name="rep_cluster_185"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.866"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 aatattactg acttcaccga aaagcaattt gaagatcgtt tagaaaagaa tgttgaacga
       61 ctaactaaaa atagactagc ggttgaatcg ccaaccgctt ttttacttgg tgggcaacca
      121 gggtcaggga aaaccagttt gcgatcagca atttttgaag aaacacaagg gaatgttatt
      181 gtcattgata atgatacctt taaacaacag cacccaaatt ttgacgaatt agtgaaactc
      241 tatgaaaaag acgtagtaaa acacgttacc ccttattcga atcgcatgac agaagcactt
      301 attagccgtt taagcgatca aggctataat ttagtgattg aaggaacagg acgaacaaca
      361 gacgttccca ttcaaacagc cacaatgctt caatctaaag gttatgaaac aaaaatatac
      421 gtcatggcag taccgaaaat tgaatcatac ttaggaacga ttgaacgata tgaaaccatg
      481 tatgcagatg atccaatgac agctagggca acaccaaaac aagcgcatga tattgttgtc
      541 aaaaacttac cgaccaattt agaaaccctt cataaaacgg gcttatttag cgatataagg
      601 ctttacaata gagaaggagt gaaactctat tcaagcttag aaacgccttc cattagtccg
      661 aaagagacct tagaaagaga attaaatcgt aaagtatcag ggaaagaaat tcaaccgact
      721 ttggagagaa tagagcaaaa aatggttcaa aatcaacacc aagaaacccc tgaatttaaa
      781 gcaattcaac aaaaaatgga aagcttgcag ctacctacac caccaatacc caaaacacct
      841 aaacttccag gtatttaaac cttaaaaaag gaaaagagta gttaccaaaa aacggtaact
      901 actctttttt tataaaaaca tttcctcatg ttggggtccc gagcgcctac gaggaatttg
      961 tatcgataag aaatagattt aaaaatttcg ctgttttttt ctaatttcat tttgaggtga
     1021 attaattggt agttattaga ggtgccctat acctaataat ttatctacat tccctttagt
     1081 aacgtgtaac tttccaaatt tacaaaagcg actcatagaa ttatttcctc ccgttaaata
     1141 atagataact attaaaaata gacaatactt gctcataagt aacggtactt aaattgttta
     1201 ctttggcgtg tttcattgct tgatgaaact gatttttagt aaacagttga cgatattctc
     1261 gattgaccca ttttgaaaca aagtacgtat atagcttcca atatttatct ggaacatctg
     1321 tggtatggcg ggtaagtttt attaagacac tgtttacttt tggtttagga tgaaagcatt
     1381 ccgctggcag cttaagcaat tgctgaatcg agacttgagt gtgcaagagc aaccctagtg
     1441 ttcggtgaat atccaaggta cgcttgtaga atccttcttc aacaatcaga tagatgtcag
     1501 acgcatggct ttcaaaaacc acttttttaa taatttgtgt gcttaaatgg taaggaatat
     1561 tcccaacaat tttatacctc tgtttgttag ggaattgaaa ctgtagaata tcttggtgaa
     1621 ttaaagtgac acgagtgttc agttttaatt tttctgacga taagttgaat agatgactgt
     1681 ctaattcaat agacgttacc tgtttactta ttttagccag tttcgtcgtt aaatgccctt
     1741 tacctgttcc aatttcgtaa acggtatcgg tttcttttaa attcaattgt tttattattt
     1801 ggttgagtac tttttcactc gttaaaaagt tttgagaata ttttatattt ttgttcatgt
     1861 aatcactcct gaagtgatta catctataaa taaatacaga agttaaacga tttgtttgta
     1921 attttagtta tctgtttaaa aagtcataag attagtcact ggtaggaatt aatctaacgt
     1981 atttatttat ctgcgtaatc actgttttta gtctgtttca aaacggtaga tgttttatct
     2041 acattacgca tttggaatac caacatgacg aatccctcct tcttaattac aaatttttag
     2101 catctaattt aacttcaatt cctattatac aaaattttgg ttctgttgca aagttttaaa
     2161 tctactatca aataaggtag aataatagaa aaagatagca ggaggaatga cgatgaatcc
     2221 ttttaaagga aagcaatttc agcaggatgt gattattgta gccgtgggct actatcttcg
     2281 ttataacctt agctatcgtg aagttcaaga aatcttatat gatcgtggca ttaacgtttc
     2341 tcatacgacg atttatcgtt gggtgcaaga atatggcaaa ctactctatc aaatttggaa
     2401 aaagaaaaat aaaaaatcct tttattcatg gaaaatggat gaaacgtaca tcaaaattaa
     2461 aggaaaatgg cattatttgt atcgagccat cgatgcagat ggtttaacct tggatatttg
     2521 gttacgtaaa aaacgggaca cacaagcagc ctatgctttt cttaagcggt tagtgaagca
     2581 gtttgatgaa ccgaaggttg tagtcacaga taaagccccc tctattacaa gtgcctttaa
     2641 gaaactaaaa gaatacggct tttatcaagg gacagaacat cgtaccatta aatacctgaa
     2701 taatttgatt gaacaagacc atcgtccagt aaagagacgc aataaattct atcgaagttt
     2761 acgcactgcc tctaccacga ttaaaggcat ggaagccatt cgaggattat ataagaaaac
     2821 ccgaaaagaa ggcactctct tcgggttttc ggtctgtact gaaatcaagg tattattggg
     2881 aatcccagct taaatcatag ataccgtaag ggattttatt ctttatttaa aactttgcaa
     2941 cagaacccta tttattagga atggctcttg cttatagtgt tggttctttg ataaaggtaa
     3001 acgtgtcact tgatctattt actattttac tagcggttgg ggtatcttcg gttattggac
     3061 tggtcttttc tgtaatgccc gcttcagagg ctgcaaaaaa agatttaatt gatattctta
     3121 gataaaatca gaatgacaag aatatttacg ttctagattc taaaataaaa cacaaagaga
     3181 ccaaccaggc accctattgt ttctttgtag tatagagata ttctttggct tgtaagagat
     3241 caatagagtt aggtgaccgg agttcgaaat aaaggaaatt tttgattgta taggagaatt
     3301 ctttatccct aatatttaga attttgagta tgccatgttg atgttttaga ttctctataa
     3361 atatagaggt gtatcaaagg tcaactagac tgtgcaaaat agagacactt gaaaaatcta
     3421 tcgggggtca gaaacttaat agtttttgac acataaacaa aatcgcgata taatggggtt
     3481 gagagtgttt cataaactta tgtcataaag ttaaggagat ttcgcatgat tttagagaat
     3541 aaattgggat taaccaatca agttgagttg gctaaggttg aagaaaaact cagtaaacaa
     3601 aaagcgaaag aattgtacga ttgtggaaaa ataaatgaaa tcgaagttgg tacatttaaa
     3661 ggtttatctg aaattcatga atttctattt tcggatattt acgattttgc cggaaaaatc
     3721 cgatcggtca atattgcaaa aggaaatttt cgatttgcac cagttatgta tttagaacat
     3781 tcgttacagc atattgatca gatgccacaa acttcttttg aagagattat caagaaatat
     3841 gtggagatga atatcgctca cccatttcga gaaggaaatg gccgaagtac tagaatttgg
     3901 ctggatctca ttttaaagga agaattgcaa aaagttgtag attggaactt aatcgataaa
     3961 gcagactatc tttctgcaat ggagcgaagt cccataaacg atttggaaat acgctatcta
     4021 atttccaatg ctctgactga taaaattgac gatcgcgagt tatatatgaa aggaatcgat
     4081 gtcagctatt tctatgaagg gtattctgag tatacgatag atgatttgta aaagtaggtg
     4141 gaccaaatga cgaaatatgg atatgcacgt gtctcaaccg cttctcaaag tacaaaagaa
     4201 caaattcaac agttgcttga gaacggcgta gagaagaaga atattttttc agaaaaattt
     4261 acgggtacaa aacgggatcg gccaaaattc aatcagctgt tggctggtct gaagcctgga
     4321 gatgaaatag ttgttacgaa gcttgatcga tttgctcgta acacgagaga agcattagag
     4381 atcattgaac ctttactcga tgataacgta acgatcaagg ttttgaatct aggaacgatt
     4441 gaaaatacgt ccatggggcg aatggtgaca cggacgttgt tgagtgtagc agaaatggaa
     4501 cgtgatatga ttgtggaacg tacccaagaa ggaaaaatgt ttgcaagaaa gaataatcct
     4561 aatttcagag aaggacgtcc gaaagcaaca atcacaccga agaagaggca cgcatatgaa
     4621 ctgcttactt caggtaaatc gtataaggaa gttgaagcta taaccggttt cagtcgcagt
     4681 acgcttttta gaataaagaa gaaaattgaa gaaagttaaa aaagaagtct cagcgaacca
     4741 gacaggtaaa tacttaatgc gttctagata tgagtctatt agcatgttgt gaaatataat
     4801 atttttttat ttacttgatt tctgctcaaa aaatgtgtat ggtaactgta aaaggtaaag
     4861 taattaaagg tatgctagcc acgcttacta tattaggata ccatcatata tttataatga
     4921 acgatttgtt cgtctaccaa acaacacata tcgttcagcg taagtcacgt ttaggaacgt
     4981 ggctttttta gtgttattat cgataaataa tctattgact ctattgattt tatctccata
     5041 tccctacggt gttgattgtc tttagatctt tcatttaaga accaaataac tatcataaaa
     5101 atcagcactg ctgctaatat aataaacagc attcctattg tgatattacc tattgatttt
     5161 accataacta cgattaaagt aataatggca ttcaagtctc ctttgttctc tatatataaa
     5221 ttagccataa atcatcttcc tttcaaatta agatacttgt ttgataccaa taaatagtaa
     5281 gcgtggctag catacctttt tctgtaatag caagtgttct aatagtccaa acttaatgat
     5341 ggaccgatgc tagttatagt acagtaatgt tttctttctt atctagattt ttagtaagct
     5401 ctatcagcaa atctaacaaa tctgagtcct tttcagaaac taaattaaat ctagtgttta
     5461 caacaaagtt ttcatgttct atattgttta gattatttgc ggaaaggagg gcttctagat
     5521 cttgacattc aaatctatat gcatcgtcat aaatcttact agaaggagtg cttaattcga
     5581 aattacttat tttctcatct tggaccaaga taaatttata gatagtatct ttttgtgttt
     5641 ttcttttaaa aacacaacag agtgtgttat aaggaacgtt ataattttca tcagcctcat
     5701 tttttctcca ttcaaacaaa tgataaactg caaccaagtt gccatcaatt tcatggacag
     5761 tgctctcggt aacatccttt aaagaactat caagggctaa tttatagtaa ctagagagag
     5821 gaagtaaaat tgtcgattta ctgagatggt tatcgtctat acgtgcaatc atacctaaat
     5881 caactaaggt tttattccag gtgtttatag ttttagttgt cactcctaga gactctgcta
     5941 tggtattgac cgaatgccag gaatccccgc cttcattctt tgccttaaaa cagtaataca
     6001 gatataaatt aatagctttg ttattcggta aatatttttc aagttctgtt ggtagaataa
     6061 agtaagaatc cttaatgttt tttctgaact gtctccagtc tctgtagttt tgtttataaa
     6121 gttgtgaaac ggtttttcca cctttagaaa gtcctgctat cttaaccaat cttattgctc
     6181 ctttcttgaa tctgtcatga tcatacagta ttttttactt gtagtccagc accttaatat
     6241 attatcctat gtaattaatt tcgtactaga tagtaattat tttttattta attctctagt
     6301 cacttacaaa taagttatat aaactacgat taataaatta ttacaaaaac tattaagaaa
     6361 acttctacat acaactatta caaaactatt aagaaactga atactcctat tttttgtttt
     6421 taaggaaagt tttttctttt ttgaatttct tatttttttc taatataact aagcaaaact
     6481 ggataatacg acacttattt tcaaattttc acaagactaa tagtaaatat ccatttaata
     6541 aagtgataca atgtgttgat tttacaaatc aacagaagaa gtagggaaat aacttaccta
     6601 tgcttctttt tttgtacatt taatcgattc ttctttacaa aaacgaacgt atgtttgtat
     6661 aatgtggaag aatggagtgt tatttatgat ggattattca aaagagccag taaatgatta
     6721 ctttttgatc gatatgaaaa gcttttacgc aagtgtcgaa tgtatagaaa ggaatttaga
     6781 tccattaacg actgaattag tcgtcatgag tcgagcggat aatacaggat cagggttgat
     6841 tttagcttct tcaccagctg caaagaagaa gtacggtatt tctaatgtca gtcgaccacg
     6901 agatctaccg caaccttttc ctaaaacgtt acatgtcgtt ccaccacgca tgaatctcta
     6961 tattaagcga aatatgcagg taaacaatat tttcagaagg tatgtagcag acgaagattt
     7021 attgatttac tcgatcgatg aatcgatctt aaaagtgacc agatcaatga atctttttac
     7081 gactgaagga acaagaagtc aacggagaaa gaagctggct caaatgatcc aggagaatat
     7141 taaagaagag ctaggattgc ttgctacagt aggtgtcgga gataatccct tattagctaa
     7201 acttgcttta gacaatgaag caaaacataa tgatggattc cttgctgaat ggacgtatca
     7261 aaatgttcct gataaagtat ggaatattcc tgaaatgaca gacctttggg gtattggatc
     7321 tcgaatgaaa aaaagactca accaaattgg tatcatgagt attaaagact tagctaattg
     7381 gaatccatac actattaaga gccatttagg tgtgattggc ttacagctgt attttcatgc
     7441 gaacgggatc gatcgaacag atatagcgat cccaccagaa ccgacaaagg aaaaatcata
     7501 tggtaattca caagtgttac cacgagatta taccaggaga aatgaaatcg aactggtggt
     7561 aaaagaaatg gcggaacaag tagctattcg tatcaggcaa cataactgta aaacaggttg
     7621 tgtccattta tacattggca cgtcgatctt agaaacgaga ccaggttttt cacaccagat
     7681 gaagatccct ataacagata atacaaagga attgcagaat tactgtcttt tcttgtttga
     7741 taagtattat gaaggacaag aagtaaggca cgttggaata acctatagca agcttgtgta
     7801 cactgattcg cttcagctgg atttatttag tgatccacaa aagcaaattg acgaagaaaa
     7861 tttagataaa attattgaca agattcggca aaaatatggt tttacgtcga ttgtacatgc
     7921 ttcttctatg ttagaaggcg ctcgtagtat tactagaagt acattggttg gtggccatgc
     7981 aggcggcgca ggagggctta aaaatgattg attataatga tcgtggacgt ttaaagtggg
     8041 caggttttta tttatctgat catactgaaa aaattgatgc cgacaatgaa caacgagcca
     8101 atcaaaattt ggcaaaagaa caaatgacga ctgaagaggt tgcggaagta ttgaacgctg
     8161 cagtcataaa aaatagatca gtatgtattc aaaaagaaga acgaaacgct gaaggatact
     8221 atccagaaga tattgttagc aagatcttag gtagtgatga gctggggatc tacgttggaa
     8281 aaaacaaagt tcactacgac gaaatacgtc atatcgaatt ttaccaggat aataaatggg
     8341 gtcgattaga atgaacatta tccagcaata tgagctaaag tatataacct ttgatcagct
     8401 atcagaagag atttggggtt atggccagcg tttgataaat gaggttggtg ttgaacgctt
     8461 ctctttctat gtagaagctg cagcaggata ccataaatac gaatactata ttggctatta
     8521 aagtgcaata aaattatatt tcttttatgt tttacatttt gtatcaattc tgataaaatt
     8581 acctataggt aattaaaaaa tataaaaaaa ctagttacaa ccttaggacg ttgtaactag
     8641 cttgaagcat actagagcta actaaaatag cactagaaag caatgttaaa cccgtccaac
     8701 aaacttgatt taacattgag accagcttat tcagctaaat atagttgaat aagcttcttt
     8761 tgttttaaaa aaacaaaagg tgtactacga ataacgcaag taaaagaaat actattacaa
     8821 ccagtaggct acaagtaagt attactaaac attgcgtagt tagaaccttt gctctattgt
     8881 ctaaagccac aaaattagag atcagcttta tgatgctaag agcgagctgc atccatgcgg
     8941 acataggttc ttttgacact attaattctc ctttttagga taagggaaat tgctagtagt
     9001 tttttcatta gcaccatccc ccttcatttg attgagtcta gtgctgctgt gatagtttgc
     9061 tgtttaatat gcttacattc ttattataac ataaatgaaa caaacacatg gttagaggtc
     9121 gtatcaatca aaatagtgtc tcacaaacga tttattactt actcctgctg actaacggac
     9181 tgttcttcag taactgtaac tatatgtttg ttaaaaccac cattacctgt agataaaaac
     9241 caatatattt actatactca ctatattaaa tatatttagt atagtaaaaa ctagaaacaa
     9301 taaaatttgt gaatgttgta tacccccaaa caatacacat attttgaagg attaggatta
     9361 ataaagctaa aaatatagta agtatactaa atatatttac tatatctagt atacttacta
     9421 tattttaatc ttttgatcgt ctattatata taatccgttc ctcgtcgttt aaagtatcaa
     9481 cataggcgtc cattgcaagt ttgactattt catacatagg aatatctttt gcataactaa
     9541 gatcccgaat ggtttttagt acgggaggat ctacttgaac tggttttctt tctttcgcag
     9601 tgtactttcg ttcccctaac tcgacattaa tatcatcttt aattgaaata tcttcagcac
     9661 caattttctt cttatctttg ttcgttggta ataatgccat ttagtttaat ctcctttcca
     9721 agaggtagga tatgattggc cattgagtca gcatatttag gtgtataatc aaatccttca
     9781 atatcaccat gttgttcata gtattcaatt ctttcttcta attctgtaaa gatgtctgca
     9841 aaaatagccc accatcttcg atctacataa tcatttaatt ggataccatt ctcaccatac
     9901 atttctaacc gatccgagcc tttaacaatg cttttaaaaa tgtttgattc accatactta
     9961 tcaattgttt tttgatagtt tgcgtgttga gaggaacgtc gcactgagaa aagaacaggc
    10021 aaaattccaa tgatttgaag atgagactct tcaaaattcg tgacaatcgg aactaaaact
    10081 ttattaataa aatcttctgt tccttccatt gcgtaccgtt ttaattcttg cattgcaata
    10141 atataatctg cagcagttaa gaatgcacga accacattat ctgttgatgg tgggcagtcg
    10201 ataaagatat aatcgaaatt ttttctcaat tcttctaaag gtttaatgaa ggccaatgat
    10261 ctcttacgac gatcaggata tttttcggac aagtattcat taagttcttc agatccagga
    10321 gagccagcca taatatataa atgtggactt acttgagtaa tacctgaaac ccagtcccct
    10381 tttttgattg ctgcagacat ggatcgatca aagctagtaa tttgatacgt tgatccaatg
    10441 ttggaagtag tatttctttg ttggtcataa tcaattagca acacgtcttt ttcaaaaagt
    10501 tgactagaaa caatcgctaa taaatcattg tctgtagtct taccaatgcc gccttttcta
    10561 cctgtaagca ttacaacttt tcctagttta tctgatgttt taaatgcagt ccgtaagttt
    10621 tccatagttc cctccaattt cctatactaa atatatttag tatacttcat atacttaata
    10681 tattcgatat atctaatata ctccaaattg ataagaattc agactttata aggaatatag
    10741 tggatatact aaatatattt gctatattca gtatatcaga tatattcaaa atgtcaaaat
    10801 atatttgtgc gttttgcgtt gacaatttag agtgaaaaga ggtaaactta attctataga
    10861 aaccacagat aattcactat ttacaaagta gcaaaagcag tggtactctt taaacagaaa
    10921 aattacataa aaaaaagaga cggaaataat tgattttagc agaatcaatt atttctgaat
    10981 cacatggtta ggacatgtgt tcacgctcgt ctcaagaata tgtaagtagc taccaactac
    11041 ttatattaaa agttgatcgg ataccttttc cgattgcctt tattctacca aaaaaaggcg
    11101 agcaactcaa cagaagaacg tttatttagt gtacttaaat taaatattct taaacactga
    11161 agagagaaca catactatgg ctgagattaa agctaaactg tgttctcttt ttgtttgaga
    11221 aaggacgtta caatcgatgt tgagcgaaat ttattcagct attcttaaaa acggcttacg
    11281 tacatacaaa tatcgaaaca gcaccatgaa acctgcaggt catattgatt ccagtaggag
    11341 tggtgctatc tttgcgtacc gtagcaagca attaatgaat gttgggcgtg gtatggtcat
    11401 tacttcggaa gaagctattt tagagaacga aaagaaacta acgcattgga cacctaatac
    11461 ctatcgcttt ggtacttatg cggatgatta tcgaacagtg gttaaaggtc attctgagaa
    11521 aaacttaagt caaatcaaca catttgtagt tgatatcgat tcaaaagaga accatcaagg
    11581 cgaaattatt ttagcctgtt tagatcaagt gggctacatg ccaacgctaa ttttagaatc
    11641 agatcatggt tatcaagttt attttgtact aaagacacca ggctatgtca caaagaaaag
    11701 caatttcaag gtgatcgatg tagcaaaaaa aatttcaaaa acaattcgtc tacagttggc
    11761 tgaaaaattg tccggagtgg atctaggatg taaccacttc ggaattgctc gattcccaca
    11821 agaaaataat attgttttta aagaaatgaa ctatcagtat tcttttgctg actggattca
    11881 atggtcgatg aagcttgaat cagatcaaaa aacaaaagaa gatcgagaac gaaaactaat
    11941 tgtctttcct gagaaaaaag aaattcgtca agtagatgaa ccgtggttcg atatgttact
    12001 tcataaagca aacatcgtcg gcggagaagg acgtcttggt cgaaataatg tgattttcac
    12061 gctttcttta gcttattact cttcaggtta tgcattggat acttgcgaat acaatatgtt
    12121 cacattcaac gaacggttac aggaaccgct atctgaagca gaattagtaa agattgtacg
    12181 tagtgcttat tctggtaatt atcaagcagc aagcagagaa ttcattattg aattgtgcca
    12241 gcaatgggtt tcaccaacct taaaaaataa tgatctgttc attcaacgac gtggctggtg
    12301 gaaatttaaa aagccacgag atcaaagaaa atatagtcat aaaaatgaat ggaaagaaga
    12361 tctattggct tatctaagcg aaaaaagtct tgctagtgag ccttatttga acctgtcaaa
    12421 aaaagaattg gcttcacaac taacgatgcc caagcgaaca cttgataaga tcttaaatga
    12481 gttacgagag gagaataaag tcttctacaa ggtaacacga ggaagaaatg gcggaatgat
    12541 cattgcttca gtcaaaacgt tgttcgcgag ggttattcaa ctaagtaaag aaaagagact
    12601 agattattca acaaggatca cagaggtatt tggactcaac gagagcttag tagaagagac
    12661 atttagacaa ttatcaaccc ccttgaaccc tcttaaagaa gtgaatcttt ttgaagtaga
    12721 tacaggttga aaaataaaag gtgcaaattg ccttatacaa tatatctatg atacttctgt
    12781 aggtgttgct ccctttgcct agctacgtgt aggtggtata cttataactg cgtatgcagt
    12841 cttatgtatc atggaggaag ttgtatgtcg ttaaaaaatt atgtctattc acatcctgtt
    12901 aatgtgttta tcattggtcg tttgggatta tctgtggaag tgttctgtga gctttatggt
    12961 tttaagcagg ggactttgtc ttcttgggtt accagggaaa aaacagttgc ttctttgccg
    13021 attgagtttc ttcatgggtt gtccttagct tctggggaga ctatggatca ggtatatgat
    13081 tgtttgtgtg tgttagagca ggagtatatt gagtataaaa tagctaacga gttaagaaaa
    13141 aggaagaagt atatccagta gtagttttta tttacttaaa aaattggttc attgagcaac
    13201 ctatcgctgc taaagtagca aaggaaaacg ttaaaggaaa gaatttaggg aagaaatcga
    13261 aatgaaatcg gacgactgga ttgaacacac ctggcttcct ctgaaaagaa atagcaaacg
    13321 aaagaaattt tgggtattgc aattatggcc attaggaaaa ctttgtagtt acggggcacg
    13381 acttattctt gatttaaccg tttactcgat tggagtattt ggaacggctt attacttgat
    13441 aaatgatccc aataggattg cagcatcaga catttttaca gtgctaatga cgttgatttt
    13501 tgtcatgcta ttgtctattt ttactcaatt agtcatgcaa tttaccaggc aaaaattaac
    13561 agcaggaaaa cttttcaaaa gcctattcga tttaattgtt gtaaatgcaa ttctagcgac
    13621 tttaataaaa caaattgaac aatctggaag aacaacaaaa ggagtgaagg attttttatt
    13681 gacgtttatt cactttgtaa atggacacat gtatttgttt gaagtgggta ttattctctt
    13741 ttttgtcggg tatgtatcca cgaaacttat taaacgttca attgaaaaag aaattgaaat
    13801 tgacctgatt ccgacacttc ttggttatga gtacaatgtt gattttggaa gatatgacga
    13861 attgatcaat acggatatcg ttcacacgag tatccatgaa tctactgtta agggcatcag
    13921 atctatttta aaaaatggcc aggaaatgaa agcaatagat cgaagaaaag agatctacaa
    13981 tttttatgaa gtcgaagcaa gcctacgata tggcatcgga aaattgtggt tagatggaag
    14041 taatattcgt caaaacaaac catacatttt ttggaacagt agtgatttag aacttccaat
    14101 gaaagataaa taattatgga gaatcgtttg aaaatgattc ctctatacag gattgtgctt
    14161 atagttggca tggagttaaa aaccttaaag aaggagcagt tattcaaagt gaaagaacgt
    14221 cataatcagt tactatgtag taaaacgggt acgatgaaca ttgaataccg aacagaatat
    14281 ttagaattaa cgaatcaaac tgattttttg ttgattcgaa agcaacaaga gcaagaaaaa
    14341 aattaatggc tacttatagc caattgattg atgaatggga acaattcaag gaatctaaaa
    14401 ttccagaacg tctctaaaag cctttatttg taaagagcat aaggaaacgt gggaacactt
    14461 tttaaaaaaa gtgttccaat aggctgtgcc tattacgttt ctcaaaaata aatgtgggaa
    14521 caaaatattt aaaaatagga tagtgaaagg atagtgaagg atagtaaaag gagggtagta
    14581 ggatagcaaa aaggataggc tccttttcgc tatccttttt aaattggagg aattaatatg
    14641 gaagtaagaa taagaaatgt ggatgagaaa atcgtaagag aaattgatcg aagatgtgac
    14701 gaacggttct gttgcaaagt tttaaatcta ctatcaaata aggtagaata atagaaaaag
    14761 atagcaggag gaatgacgat gaatcctttt aaaggaaagc aatttcagca ggatgtgatt
    14821 attgtagccg tgggctacta tcttcgttat aaccttagct atcgtgaagt tcaagaaatc
    14881 ttatatgatc gtggcattaa cgtttctcat acgacgattt atcgttgggt gcaagaatat
    14941 ggcaaactac tctatcaaat ttggaaaaag aaaaataaaa aatcctttta ttcatggaaa
    15001 atggatgaaa cgtacatcaa aattaaagga aaatggcatt atttgtatcg agccatcgat
    15061 gcagatggtt taaccttgga tatttggtta cgtaaaaaac gggacacaca agcagcctat
    15121 gcttttctta agcggttagt gaagcagttt gatgaaccga aggttgtagt cacagataaa
    15181 gccccctcta ttacaagtgc ctttaagaaa ctaaaagaat acggctttta tcaaggaaca
    15241 gaacatcgta ccattaaata cctgaataat ttgattgaac aagaccatcg tccagtaaag
    15301 agacgcaata aattctatcg aagtttacgc actgcctcta ccacgattaa aggcatggaa
    15361 gccattcgag gattatataa gaaaacccga aaagaaggca ctctcttcgg gttttcggtc
    15421 tgtactgaaa tcaaggtatt attgggaatc ccagcttaaa tcatagatac cgtaagggat
    15481 tttattcttt atttaaaact ttgcaacaga acctataaaa gccctttaaa gagggctttt
    15541 atatattaat cacaaatcac ttatcacaaa tcacaagtga ttaatcacaa atcacttgtg
    15601 atttgtgatt cttaatgata caatattact atacaaaaaa agaatggggc gtagttatgg
    15661 agaaggaaaa actaaaaata cttgaagaat taagacgtat tttaaacaat aaaaatgaag
    15721 caattattat cttgaataat tactttaaag gtggtgttgg aaagtccaaa ttatcgacta
    15781 tgtttgctta cttgacagac aaattgaatt taaaagtttt aatgatcgat aaggacttac
    15841 aggcaacatt gacaaaagac ttagcaaaaa cttttgaggt agaattgcca cgtgtcaatt
    15901 tttatgaagg cttgaaaaat ggaaacttgg cttcttctat tattcatttg actgataatt
    15961 tagacttgat ccctggcacg tttgatttga tgttactgcc aaaattaact cgctcatgga
    16021 cgtttgaaaa tgaaagtaga ttgcttgcta ctcttttagc acctttaaaa agtgactatg
    16081 atcttattat tattgatact gtaccaacgc caagcgttta tacaaataat gcaatcgtgg
    16141 cgagtgatta cgttatgatc cctttacaag cagaagaaga aagtacaaac aacattcaaa
    16201 actatatttc ctatttgatt gatttgcaag aacagtttaa ccctggacta gatatgattg
    16261 gttttgttcc ttatttagtt gatacggaca gcgcaacgat aaaatcaaac ctggaagaac
    16321 tgtacaaaga acataaagag gataatttgg ttttccgaaa tattatcaag cgaagtaata
    16381 aagtaagtac ttggtctaaa aatggcatta cagaacacaa aggctatgac aaaaaagttt
    16441 tgtctatgta tgagaacgta ttttttgaaa tgattgagcg aatcattcaa ttagaaaatg
    16501 aaaaagaata gaatcacaaa tcacttgtga tttgtgatag gtgatgataa aataaatagt
    16561 aagaagaaat agaaagaagt gagcgatcgt gggaaattta ggcgcacaga aagcaaaacg
    16621 aaatgatacg ccaatcagcg caaaaaaaga tataatgggg gataagacgg ttcgtgttcg
    16681 tgccgacttg caccatatca taaaaatcga aacagcaaag aatggcggaa acgtaaaaga
    16741 agttatggat caagccttag aagaatatat acggaaatat ttacctgaca aactttaaaa
    16801 ggagtgaaaa tgaaatggca gttacgtatg aaaaaacatt tgaaattgaa atcattaatg
    16861 agttatcggc aagtgtttat aatcgggtat taaattatgt tttgaatcat gaactagata
    16921 ctaaaaatac tcgtttacta gaagtgaatc ttttaaatca attagaagtg gcacaagaag
    16981 ttgatttatt tcaacaacca tttgaagaat tacaagctat tcatgagtat tggcggtcaa
    17041 tgaatcaata ttcaaaacaa attttgaata aagagaaagt ggcttaacat ggcg
//
