LOCUS       CP063602               19255 bp    DNA     circular BCT 04-APR-2022
DEFINITION  Enterococcus faecium strain BMT-3-2-1 plasmid pHJB-2-1_04, complete
            sequence.
ACCESSION   CP063602
VERSION     CP063602.1
DBLINK      BioProject: PRJNA669626
            BioSample: SAMN16483157
KEYWORDS    .
SOURCE      Enterococcus faecium
  ORGANISM  Enterococcus faecium
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 19255)
  AUTHORS   Both,A., Kruse,F., Mirwald,N., Franke,G., Christner,M., Huang,J.,
            Hansen,J.L., Kroger,N., Berneking,L., Lellek,H., Aepfelbacher,M. and
            Rohde,H.
  TITLE     Population dynamics in colonizing vancomycin-resistant Enterococcus
            faecium isolated from immunosuppressed patients
  JOURNAL   J Glob Antimicrob Resist 28, 267-273 (2022)
   PUBMED   35134550
REFERENCE   2  (bases 1 to 19255)
  AUTHORS   Both,A., Kruse,F., Christner,M., Huang,J., Mirwald,N., Franke,G. and
            Rohde,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-OCT-2020) Institute of Medical Microbiology, Virology
            and Hygiene, University Medical Center Hamburg-Eppendorf,
            Martinistr. 52, Hamburg, Hamburg 20246, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Trycycler v. v0.3.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 479.5x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 10/27/2020 18:05:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.13
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 3,214
            CDSs (total)                      :: 3,122
            Genes (coding)                    :: 3,008
            CDSs (with protein)               :: 3,008
            Genes (RNA)                       :: 92
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 114
            CDSs (without protein)            :: 114
            Pseudo Genes (ambiguous residues) :: 0 of 114
            Pseudo Genes (frameshifted)       :: 39 of 114
            Pseudo Genes (incomplete)         :: 69 of 114
            Pseudo Genes (internal stop)      :: 15 of 114
            Pseudo Genes (multiple problems)  :: 8 of 114
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..19255
                     /organism="Enterococcus faecium"
                     /mol_type="genomic DNA"
                     /strain="BMT-3-2-1"
                     /isolation_source="rectal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1352"
                     /plasmid="pHJB-2-1_04"
                     /geo_loc_name="Germany: Hamburg"
                     /lat_lon="53.33 N 10.1 E"
                     /collection_date="2015-02-03"
                     /collected_by="Institute of Medical Microbiology, Virology
                     and Hygiene, University Medical Center Hamburg-Eppendorf"
     gene            1..312
                     /locus_tag="IQN09_15940"
                     /pseudo=""
     CDS             1..312
                     /locus_tag="IQN09_15940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000277654.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /name="replication initiation protein"
     gene            419..811
                     /locus_tag="IQN09_15945"
     CDS             419..811
                     /locus_tag="IQN09_15945"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000393259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="UOC42588.1"
                     /translation="MEEVLIDDNMVFDIDNLKGFLNDTSSFGFIAKENNKIIGFAYCYT
                     LLRPDGKTMFYLHSIGMLPNYQDKGYGSKLLSFIKEYSKEIGCSEMFLITDKGNPRACH
                     VYEKLGGKNDYKDEIVYVYDYEKGDK"
                     /name="GNAT family N-acetyltransferase"
     gene            812..2251
                     /gene="aph(2'')-Ia"
                     /locus_tag="IQN09_15950"
     CDS             812..2251
                     /gene="aph(2'')-Ia"
                     /locus_tag="IQN09_15950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002390775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside O-phosphotransferase APH(2'')-Ia"
                     /protein_id="UOC42578.1"
                     /translation="MNIVENEICIRTLIDDDFPLMLKWLTDERVLEFYGGRDKKYTLES
                     LKKHYTEPWEDEVFRVIIEYNNVPIGYGQIYKMYDELYTDYHYPKTDEIVYGMDQFIGE
                     PNYWSKGIGTRYIKLIFEFLKKERNANAVILDPHKNNPRAIRAYQKSGFRIIEDLPEHE
                     LHEGKKEDCYLMEYRYDDNATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNE
                     YIFKTKFSTNKKKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTF
                     LTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRETIY
                     NDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNNRLTGIIDFGDSGI
                     IDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKEYQDIVEEYYPIETIVYGIK
                     NIKQEFIENGRKEIYKRTYKD"
                     /name="aph(2'')-Ia"
     gene            2433..3080
                     /locus_tag="IQN09_15955"
     CDS             2433..3080
                     /locus_tag="IQN09_15955"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000143686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type A-8 chloramphenicol O-acetyltransferase"
                     /protein_id="UOC42579.1"
                     /translation="MTFNIINLETWDRKEYFNHYFNQQTTYSVTKEFDITLLKSMIKNK
                     GYELYPALIYTIVNIINQNKVFRTGINSEGNLGYWEKLNPLYTVFNKETEKFSNIWTES
                     NVSFNSFYNSYKSDLLEYKDKNEMFPKKPIPENTVPISMIPWIDFSSFNLNIGNNSRFL
                     LPIITIGKFYSKNNKIYLPVSLQVHHAVCDGYHVSLFMSEFQNIVDSVNEWI"
                     /name="type A-8 chloramphenicol O-acetyltransferase"
     gene            complement(3227..3907)
                     /locus_tag="IQN09_15960"
     CDS             complement(3227..3907)
                     /locus_tag="IQN09_15960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002338443.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="UOC42580.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSIASAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASPTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPD"
                     /name="IS6-like element IS1216 family transposase"
     gene            4032..6383
                     /locus_tag="IQN09_15965"
     CDS             4032..6383
                     /locus_tag="IQN09_15965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000344083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1906 domain-containing protein"
                     /protein_id="UOC42581.1"
                     /translation="MDEMVLSTQKWLNKKYSNVTGFDKVPENGRTGWPTIYGLIEGLQV
                     ELGITNLVANFGPTTEKMYDNQVTPKWGKNLPKNIVFLIQGAFWCKGINPGGFDGVYTP
                     YLDTAVKELQTDAGFNGSAVTGVLDAKWAKALFDMSAFVLVPGGDSKIRKMQQWLNVNY
                     LEYTGIMPCDGIYQRNSNQALIFALQAELGYSPSEATGSYGNGTTSKTYPVSEGNSGNY
                     VRIIQYGLYVNGYFEDGTFDGIFTKYMGLEVLAFRKFMVLPEYTEIADVVVIKGLLSSA
                     GDIRRSADGADTSTQLTRSQIQTLVDNDIKIVGRYLTGTVGIGKDERNKYLTTEELNNI
                     FSKNLSVFPIYQDGGAALAYFTYDRGLSDGKKAIDAAKNLNIPLTTVIYFAVDLDMLGE
                     EILAYAGEYFKGVSAVMSYSGYQTGVYGTRNVCSQIINNGYASFAFVSDMSTGYSGNLG
                     FPMPRQWSFDQFVEFTIGSGNGAVGIDLIATSGRDSGFNELSNDTNNDNYIAKYNQKVI
                     NQMVRAYQYLSQAGLDNPWNPHLTFYRYVNYSGLSWDIISSPVTEHDRKIYDEYRNKLT
                     NSEGLYNYFIDPNTGSIIGLPHLIVTLQSQMFLADTINDSVSDFAGWLGDLMTCWGEVK
                     KLGIQMEQGVFALVGTAAGGTFSLEDLYQDVDAVNVYTLAKRNSDSTALSALKTYYCDK
                     GAIDRFNQFVKNRFGSSDKIASVTNSLLENDETVDILGVGIISFFIDKIVNNSLGTDFT
                     YLDFIGDEGKVANGFSEKIIQFQENRSKLN"
                     /name="DUF1906 domain-containing protein"
     gene            6463..6858
                     /locus_tag="IQN09_15970"
     CDS             6463..6858
                     /locus_tag="IQN09_15970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002304891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC42582.1"
                     /translation="MMIMEEIEWNNLTQNNKNNSGCGIIFMFVIVLGIVVLLITVKIVD
                     YFANTPEEQIQRKLPEFERVPPYDPRDNSFQVKKLKESPNEMWFEVTVESSDFKEKKKE
                     YNYIVKAKVSKRFIFNPKLEIYSVVIE"
                     /name="hypothetical protein"
     gene            7183..7800
                     /locus_tag="IQN09_15975"
     CDS             7183..7800
                     /locus_tag="IQN09_15975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001224538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="UOC42583.1"
                     /translation="MRKFFYIRVSSYDQSIERQLISAKELGIPEEYIFVEKASGKDFKR
                     PEYQLMKRMFRKGDLLYLQSLDRLGRNKQMILEEWRELTKEKQIDISVLDMPLLDTASY
                     KQLDGLETLISDLILQLLSYMAEDERKRINSRQREGVEAAKQKGVKFGRKKIALPPEFP
                     AIYSDWKAGKITAVYAMDQLGMKRNTFYRRVKEYEHTLHHFS"
                     /name="recombinase family protein"
     gene            7841..8140
                     /locus_tag="IQN09_15980"
     CDS             7841..8140
                     /locus_tag="IQN09_15980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000366408.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BRCT domain-containing protein"
                     /protein_id="UOC42584.1"
                     /translation="MDLTNQRVVFTGTLQQMTRTQAIGLVHSLNGHCQSSVTSKTNFLV
                     CGQYSKSLFDDSLYTKKEQTARDLIALGHEITILSEVEFYALISQQLKEWQRYL"
                     /name="BRCT domain-containing protein"
     gene            8174..8371
                     /locus_tag="IQN09_15985"
     CDS             8174..8371
                     /locus_tag="IQN09_15985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002412976.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="UOC42585.1"
                     /translation="MKRKSYDRWGIEITSFNRNIAFHVECDCGELAKSVYQKNYFYCPK
                     CHRRYKQKQGEYVAITIIKE"
                     /name="transcriptional regulator"
     gene            8767..9006
                     /locus_tag="IQN09_15990"
     CDS             8767..9006
                     /locus_tag="IQN09_15990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010621028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC42589.1"
                     /translation="MEQSDNVPLDRHKCKEHVFKDKRFVEKESESLTLLGYKIVVDTVT
                     GVNYLETPKGGITPLLDKNGKICIDKKKSINKKG"
                     /name="hypothetical protein"
     gene            complement(9039..9323)
                     /locus_tag="IQN09_15995"
     CDS             complement(9039..9323)
                     /locus_tag="IQN09_15995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002412979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC42586.1"
                     /translation="MSSLINRKIPQGATANKEADTKRKVTIQKKSSKKILASERKNIKV
                     SPSTFDLIKTISTMKSYKNYEFIDKAVESYIQNNLTEREQRILKNLISK"
                     /name="hypothetical protein"
     gene            complement(9316..10206)
                     /locus_tag="IQN09_16000"
     CDS             complement(9316..10206)
                     /locus_tag="IQN09_16000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016615412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="UOC42587.1"
                     /translation="MANTIIFGQQKGGVGKTTDTCMITLVAAMLMKKRTILIDIDLQAN
                     ATNFMTKTFGVETVPQTLMSALENGDLRPAIVNLKENLDLIPAGYDMRLYTEFLTENFD
                     NTIDRTFYLKNLIEEIKDDYDYIFIDIPPSTDLKVDNAMVACDYLVVVQETQQFSFEGS
                     QRLIFDYIQTLVDDFGSDVPIQIAGILPALLQQKRPMHQKLVEETIDTFGRDNVFNTII
                     QNHARLEWYPRIGFQFQDYHDKKMIALFADIFCELEERITLYKSNGDIQDYFYTPRYIL
                     DGKLTSLGKEISLNV"
                     /name="AAA family ATPase"
     gene            10910..12415
                     /locus_tag="IQN09_16005"
     CDS             10910..12415
                     /locus_tag="IQN09_16005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002360897.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primase C-terminal domain-containing protein"
                     /protein_id="UOC42573.1"
                     /translation="MKVSDVISVILKSGIREYKCLNSKIKPIGYKAEGKKGAIFGFRSK
                     KLMTESRGIVLTSQEGLAENEDKFTHWTPNVYSYGAYADEKRIIVKGHNERNLQQINTF
                     VIDFDRLTGEKLDSQMILDAAIDLELMPTLILETPGGFQAYFILENAWYISSKNNYQSI
                     EVAKRVSENLRKAFAEELPSVDLGCNHFGIARIPRTDNIVYYYPALTHDIQQLIQWSMK
                     YEPAKTYKKPLLSLVKNKYKQVNEMWYRQLISNPKIVGAKGIMGRNNVIFTLSLANYAS
                     GVDLEDCLNEMDLFNSSLERPLKDRERVRIVKSAYSGKYRGASKTYVQELVSNWGLESL
                     SEEKMFTQQRNTWYKFKKERHKRKKSHLSEWKEDILAYLETQCYRYRPEVRLKKTDLQA
                     AITFNGQSIPKRSLDRALKELMAEGKLFVQIKAGRNGGLVVATRKALIRTVIQVKQQVK
                     SAYKQGIKTFFKEADMLVRIFREPDKYSQRVDHYKQLNLWNTG"
                     /name="primase C-terminal domain-containing protein"
     gene            complement(12542..13864)
                     /locus_tag="IQN09_16010"
     CDS             complement(12542..13864)
                     /locus_tag="IQN09_16010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001281642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
                     /protein_id="UOC42590.1"
                     /translation="MSDLLSLPDIKTIEPPQENETDMMFKVEAVGPPERCPECGFDKLY
                     KHSSRNQLIMDLPIRLKRVGLQLNRRRYKCRECGSTFWERLISVDEKRSMTKRLLKSIQ
                     EQSMSKTFVEVAESVGVDEKTIRNVFKDYVALKEREYQFETPKWLGIDEIHIIRRPRLV
                     LTNIERRTIYDIKPNRNKETVIQRLSEISDRTYIEYVTMDMWKPYKDAVNPILPHAKVV
                     VDKFHVVRMANQALDNVRKSLKAHMSQKERRTLMRERFILLKRKHDLNERESFLLDTWL
                     GNLPALKEAYELKEEFYWIWDTPDPDEGHLRYSQWRHRCMSSNSKDAYKDLVRAVDNWH
                     VEIFNYFDKRLTNAYTESINSIIRQVERMGRGYSFDALRAKILFNEKLHKKRKPRFNSS
                     AFNKAMLYDTFNWYEVNDHDITDNFGVDFSTPIKNLEKGDL"
                     /name="ISL3 family transposase"
     gene            complement(14024..15919)
                     /gene="merA"
                     /locus_tag="IQN09_16015"
     ARG             complement(14028..15919)
                     /name="merA"
                     /gene="merA"
                     /gene_name="mercury(II) reductase"
                     /tool="amrfinderplus"
                     /drug_class="MERCURY"
                     /identity="96.04"
                     /coverage="100.0"
     gene            complement(15948..16340)
                     /gene="merR"
                     /locus_tag="IQN09_16020"
     CDS             complement(15948..16340)
                     /gene="merR"
                     /locus_tag="IQN09_16020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020220203.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Hg(II)-responsive transcriptional regulator"
                     /protein_id="UOC42575.1"
                     /translation="MIYRISEFADKCGVNKETIRYYERKNLLQEPHRTEAGYRIYSYDD
                     VKRVGFIKRIQELGFSLSEIYKLLGVVDKDEVRCQDMFEFVSKKQKEVQKQIEDLKRIE
                     TMLDDLKQRCPDEKQLHSCPIIETLT"
                     /name="merR"
     gene            16629..17261
                     /locus_tag="IQN09_16025"
                     /pseudo=""
     CDS             16629..17261
                     /locus_tag="IQN09_16025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002405587.1"
                     /note="incomplete; partial on complete genome; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /name="peptide ABC transporter substrate-binding protein"
     gene            complement(17327..17932)
                     /locus_tag="IQN09_16030"
     CDS             complement(17327..17932)
                     /locus_tag="IQN09_16030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002321606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="UOC42576.1"
                     /translation="MGKIGYIRVSSQDQNLDRQLAMMEGLNIDKLFQEKASGKDTERPE
                     FQKLLNYIREGDCVIVTSLDRLGRDYEDIKNTVAFMKQKKVALKILDAQFLDFNTGNEL
                     LDTAMFDMFLSLLSYIAQNEREKIRERQRQGVLLAQKAGRYKGRPIEYSINSTDPQKRL
                     VFKTVVDMLKQGIPVAEIAKENGISRPTIYKIKKANDL"
                     /name="recombinase family protein"
     gene            18057..18323
                     /locus_tag="IQN09_16035"
                     /pseudo=""
     CDS             18057..18323
                     /locus_tag="IQN09_16035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000343406.1"
                     /note="incomplete; partial on complete genome; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4158 domain-containing protein"
                     /name="DUF4158 domain-containing protein"
     gene            complement(18378..19058)
                     /locus_tag="IQN09_16040"
     CDS             complement(18378..19058)
                     /locus_tag="IQN09_16040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002338443.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="UOC42577.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSIASAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASPTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPD"
                     /name="IS6-like element IS1216 family transposase"
     ARG             813..2248
                     /name="aac(6')-Ie/aph(2'')-Ia"
                     /gene="aac(6')-Ie/aph(2'')-Ia"
                     /gene_name="bifunctional aminoglycoside N-acetyltransferase
                     AAC(6')-Ie/aminoglycoside O-phosphotransferase APH(2'')-Ia"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             2434..3077
                     /name="catA"
                     /gene="catA"
                     /gene_name="type A-8 chloramphenicol O-acetyltransferase"
                     /tool="amrfinderplus"
                     /drug_class="PHENICOL"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             2434..3080
                     /name="catA8"
                     /gene="catA8"
                     /gene_name="chloramphenicol acetyltransferase (CAT)"
                     /tool="rgi"
                     /drug_class="phenicol antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             813..2251
                     /name="AAC(6')-Ie-APH(2'')-Ia bifunctional protein"
                     /gene="AAC(6')-Ie-APH(2'')-Ia bifunctional protein"
                     /gene_name="aminoglycoside bifunctional resistance protein"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     Typing          29..312
                     /name="rep_cluster_1118"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="3.17e-147"
     Typing          10911..12396
                     /name="rep_cluster_180"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="84.832"
                     /coverage="99.0"
                     /evalue="0.0"
ORIGIN
        1 aaaataaaaa ttgaattaaa aagagatatg gttgattatt ggaacgattg ttttaatgat
       61 ttacatatat tacaaccaga ttggaaaact atcgaacgta cttctgatag agcaatggtt
      121 tttatgttgt tgaatgatga agaagaatgg ggaaaattag aaagacgtac taagaataaa
      181 tataaaaaat taattaaaga aatatctcta attgatttaa ctgatttaat gaaatcgact
      241 ttaaaagcga acgaaaaaca attgcaaaag cagattgatt tttggcaacg tgaatttaga
      301 ttttggaagt aaagtaactt tgttttatac aaaatgttac tttagtatag tcaagtccat
      361 aatcctgtgt aaaatactat acaatgtttt acacaggagt ctggacttga ctgagtttat
      421 ggaagaagtt ttaattgatg ataatatggt ttttgatatt gataatttaa aaggatttct
      481 taatgatacc agttcatttg ggtttatagc taaagaaaat aataaaatta taggatttgc
      541 atattgctat acacttttaa gacctgatgg aaaaacaatg ttttatttac actcaatagg
      601 aatgttacct aactatcaag acaaaggtta tggttcaaaa ttattatctt ttattaagga
      661 atattctaaa gagattggtt gttctgaaat gtttttaata actgataaag gtaatcctag
      721 agcttgccat gtatatgaaa aattaggtgg taaaaatgat tataaagatg aaatagtata
      781 tgtatatgat tatgaaaaag gtgataaata aatgaatata gttgaaaatg aaatatgtat
      841 aagaacttta atagatgatg attttccttt gatgttaaaa tggttaactg atgaaagagt
      901 attagaattt tatggtggta gagataaaaa atatacatta gaatcattaa aaaaacatta
      961 tacagagcct tgggaagatg aagtttttag agtaattatt gaatataaca atgttcctat
     1021 tggatatgga caaatatata aaatgtatga tgagttatat actgattatc attatccaaa
     1081 aactgatgag atagtctatg gtatggatca atttatagga gagccaaatt attggagtaa
     1141 aggaattggt acaagatata ttaaattgat ttttgaattt ttgaaaaaag aaagaaatgc
     1201 taatgcagtt attttagacc ctcataaaaa taatccaaga gcaataaggg cataccaaaa
     1261 atctggtttt agaattattg aagatttgcc agaacatgaa ttacacgagg gcaaaaaaga
     1321 agattgttat ttaatggaat atagatatga tgataatgcc acaaatgtta aggcaatgaa
     1381 atatttaatt gagcattact ttgataattt caaagtagat agtattgaaa taatcggtag
     1441 tggttatgat agtgtggcat atttagttaa taatgaatac atttttaaaa caaaatttag
     1501 tactaataag aaaaaaggtt atgcaaaaga aaaagcaata tataattttt taaatacaaa
     1561 tttagaaact aatgtaaaaa ttcctaatat tgaatattcg tatattagtg atgaattatc
     1621 tatactaggt tataaagaaa ttaaaggaac ttttttaaca ccagaaattt attctactat
     1681 gtcagaagaa gaacaaaatt tgttaaaacg agatattgcc agttttttaa gacaaatgca
     1741 cggtttagat tatacagata ttagtgaatg tactattgat aataaacaaa atgtattaga
     1801 agagtatata ttgttgcgtg aaactattta taatgattta actgatatag aaaaagatta
     1861 tatagaaagt tttatggaaa gactaaatgc aacaacagtt tttgagggta aaaagtgttt
     1921 atgccataat gattttagtt gtaatcatct attgttagat ggcaataata gattaactgg
     1981 aataattgat tttggagatt ctggaattat agatgaatat tgtgatttta tatacttact
     2041 tgaagatagt gaagaagaaa taggaacaaa ttttggagaa gatatattaa gaatgtatgg
     2101 aaatatagat attgagaaag caaaagaata tcaagatata gttgaagaat attatcctat
     2161 tgaaactatt gtttatggaa ttaaaaatat taaacaggaa tttatcgaaa atggtagaaa
     2221 agaaatttat aaaaggactt ataaagattg attatataat atatgaaaag ctattataaa
     2281 agacattagt attaaatagt ttaaaaaaat gaaaaataat aaaggcttta gtataattaa
     2341 cgtttaagag gtgacacaat atatgaaaaa atcagaggat tattcctcct aaatacaaag
     2401 agataagatg aaatttagga ggaaaattat atatgacttt taatattatt aatttggaaa
     2461 cttgggatag aaaagaatat tttaatcatt atttcaatca acaaacaact tacagtgtta
     2521 ctaaagaatt tgatatcact ttacttaaaa gtatgataaa aaataaagga tatgaactgt
     2581 atcctgcttt gatttataca attgtaaata ttataaatca aaataaagta tttagaacag
     2641 gaattaatag tgagggaaat ttgggttatt gggaaaaatt aaacccttta tatacagtct
     2701 ttaataaaga aactgaaaaa ttttctaaca tttggacaga atcaaatgtt agttttaatt
     2761 ctttttataa tagttataag agtgacttac ttgaatataa agataaaaat gaaatgtttc
     2821 ctaaaaaacc aatacctgaa aacacagttc ctatttcgat gattccttgg attgatttta
     2881 gttcatttaa tttaaatatt ggtaataata gtagattcct attgccaatt attacaatag
     2941 gtaaatttta tagtaagaat aataagatct atttaccagt ctcattgcaa gttcatcatg
     3001 cggtatgtga tggttaccat gtttcattat ttatgagtga atttcaaaat atagttgata
     3061 gtgtaaatga atggatttaa atctaaaata actttcataa acttaagtaa ttatgatatt
     3121 tataagttta tagcaaccac attttttggt tgcttgtggt tttgattttg aaggttctgt
     3181 tgcaaagttt taaataaaga ataaaatccc ttacggtatc tatgatttaa tctgggattc
     3241 ccaataatac cttgatttca gtacagaccg aaaacccgaa gagagtgcct tcttttcggg
     3301 ttttcttata taatcctcgg atggcttcca tgcctttaat cgtgggtgag gcagtgcgta
     3361 aacttcgata gaatttattg cgtctcttta ctggacgatg gtcttgttca atcaaattat
     3421 tcaggtattt aatggtacga tgttctgtcc cttgataaaa tccgtattct tttagtttct
     3481 taaaggcact agcaattgat ggtgctttat ctgtgactac aaccttcggt tcatcaaact
     3541 gcttcactaa ccgcttaaga aaagcatagg ctgcttgtgt gtcccgtttt ttacgtaacc
     3601 aaatatccaa ggttaaacca tctgcatcga tggctcgata caaataatgc cattttcctt
     3661 taattttgat gtacgtttca tccattttcc aggaataaaa ggatttttta tttttctttt
     3721 tccaaatttg atagagtagt ttgccatatt cttgcaccca acgataaatc gtcgtatgag
     3781 aaacgttaat gccacgatca tataagattt cttgaacttc acgatagcta aggttataac
     3841 gaagatagta gcccacggct acaataatca catcctgctg aaattgcttt cctttaaaat
     3901 gattcatcgt cattcctcct gctatctttt tctattattc taccttattt gatagtagat
     3961 ttaaaacttt gcaacagaac ctaatcaaca cataaacgaa cgtatgttcg gcaagaaagc
     4021 aggggatttt tatggatgag atggttttaa gtactcagaa atggctaaac aagaaataca
     4081 gtaatgttac agggtttgat aaggttccag aaaatgggcg aacagggtgg cctacaatct
     4141 atggacttat tgaaggacta caagtagaac ttggtattac taatctagta gctaattttg
     4201 gacctaccac tgaaaaaatg tacgataatc aggttactcc taaatggggc aaaaatctac
     4261 ctaaaaatat tgtatttctt attcaaggtg ccttttggtg taaggggatt aatccaggtg
     4321 gcttcgatgg ggtatatact ccatatttag atactgctgt aaaagagttg cagactgatg
     4381 cagggtttaa tggaagcgct gtaactggag ttttggatgc gaaatgggcc aaagcgttat
     4441 ttgatatgag tgcttttgtt cttgttcccg gcggagatag taaaattaga aaaatgcagc
     4501 aatggttaaa tgtaaattat ttagaataca cgggaataat gccttgtgat ggtatttatc
     4561 aaagaaattc aaatcaagca ttaatttttg cattacaagc tgaactagga tattctccca
     4621 gtgaagcaac agggtcttat ggtaatggga caactagtaa aacttatcct gtgtctgaag
     4681 gtaactcggg aaactatgta agaataattc aatatggatt atatgttaat ggttattttg
     4741 aagacggtac attcgatggt attttcacta aatatatggg tttagaagta ctggcattcc
     4801 gaaaatttat ggtattgcct gaatatactg aaatagcaga tgttgttgta ataaaaggac
     4861 tattgtctag cgctggagat attagaagat ctgcagatgg cgcagatact tctacgcaat
     4921 taactagatc tcaaatccaa acattggttg ataatgatat aaaaatagtt ggtagatatc
     4981 ttactggtac tgttggaatt ggaaaagatg aacgaaataa gtatctaact acagaggaat
     5041 tgaataatat tttttctaaa aatttatctg tgtttcctat ctatcaagat ggaggtgcag
     5101 cattagctta ttttacttat gatcgtggct tatcagatgg taagaaggct atagatgcag
     5161 caaaaaatct aaatatacca ttaacaacag ttatttattt tgctgttgat ctagacatgt
     5221 taggggaaga aattcttgca tatgctggag aatattttaa gggggtatct gctgtaatgt
     5281 catatagcgg gtatcaaacg ggtgtttacg gaacaagaaa tgtttgttct caaataatca
     5341 ataacgggta tgcttcgttt gcatttgttt cagatatgtc gactggttat agtgggaatt
     5401 taggttttcc tatgcctaga caatggtctt ttgatcaatt tgttgaattt accataggaa
     5461 gtggcaacgg agctgttggt atcgatttaa tcgctacatc gggtagagat agcggattta
     5521 atgagttatc aaatgatact aataatgata attacattgc caaatacaat cagaaggtta
     5581 taaatcagat ggtacgtgcg tatcaatatc tatcacaagc tggtcttgat aatccttgga
     5641 accctcattt gacattttat agatatgtaa attattctgg tttgtcatgg gacatcattt
     5701 cttctcctgt aacagagcat gatagaaaaa tttatgatga atataggaat aaattaacta
     5761 atagcgaggg cctgtataat tattttatag atcctaatac tggttcaata ataggtttgc
     5821 ctcacttaat tgtgacgtta caatcacaga tgtttctagc cgacacaatc aatgatagtg
     5881 tttctgactt tgcaggttgg ttaggagatt taatgacttg ctggggtgaa gttaagaaat
     5941 taggaataca aatggagcaa ggtgtatttg cattagtagg tacggctgca ggtggaacat
     6001 ttagtctaga agatttatac caagatgttg acgcggtaaa tgtttatacc ttagcaaaaa
     6061 gaaattctga ttcaacagct ttatcggctt taaaaacgta ctattgtgat aagggtgcta
     6121 ttgatagatt taatcaattt gttaagaaca gatttggttc ttcagataaa atcgcttcag
     6181 taacaaatag tttattagaa aatgacgaaa cagttgatat cttaggtgta gggataattt
     6241 catttttcat tgataaaata gttaataatt cacttgggac agattttact tatcttgatt
     6301 ttattggaga tgaggggaaa gttgcaaatg gattttctga aaaaattatt caatttcaag
     6361 aaaatagaag taaacttaat taagaatcgt ttactattta aacagtgtcc ttttcctttt
     6421 taaatatata cgataaaata agtatatgaa ttgtaaaagg acatgatgat tatggaagaa
     6481 atagaatgga ataatctgac tcaaaataat aaaaataatt ctggatgtgg aattatcttt
     6541 atgtttgtta tagttttggg aatagtagta cttttaataa ctgtcaagat agtagattac
     6601 tttgcgaata ctcctgaaga acaaatacag agaaaacttc ctgagtttga aagagtacca
     6661 ccttatgatc caagagataa ttcatttcaa gtaaaaaaat taaaagagtc tccaaatgaa
     6721 atgtggtttg aagttacagt tgaatcaagc gacttcaaag aaaaaaagaa agaatacaat
     6781 tatattgtaa aggcaaaagt atcaaaaaga tttattttta accctaaatt agaaatatat
     6841 agtgttgtaa tagaataata gtgttaaaaa aattgtaaaa gttaaagaag tcaaattctg
     6901 atgtgaaaaa taaaatatac catggaagac ataaaagaaa aactggataa ctagtttatt
     6961 taatggcaga ccgttaaggc ctgccatttt tatgtatttt agcggaataa atataatcat
     7021 gcgggagtgt aaacttactg tttcaaaaag tatacttttt gacatgcctt gattttcttt
     7081 gtttatgtat ggcataataa ccacataata caatttgaaa cgtttctgat ttaatctgat
     7141 tgttttgaaa caattttagt gaaaaaaggg tagataaaaa cgatgagaaa atttttttat
     7201 atccgggtca gtagttatga tcaatcgatc gaacgacaac tgatttccgc gaaggaatta
     7261 ggaatccctg aagaatatat atttgtagaa aaagccagcg gcaaagattt taaacgccct
     7321 gaatatcaat taatgaaacg gatgtttcga aaaggagatt tactctatct acaatcatta
     7381 gatagactag gcagaaataa acaaatgatt ttagaagaat ggcgagaatt aactaaggaa
     7441 aagcagattg atatttctgt gttagacatg cctctgttag atactgctag ttacaagcaa
     7501 ctagatgggt tagagacgct tatctctgac ttaattctgc aattactcag ctatatggcc
     7561 gaagacgagc ggaaacgaat taatagccgg caaagagaag gcgtagaagc tgcgaaacaa
     7621 aagggtgtaa aattcggcag aaagaaaatt gctttacctc ctgaatttcc tgcgatctat
     7681 tctgactgga aagcaggaaa gataactgca gtctatgcta tggatcaatt gggcatgaaa
     7741 cgaaatacct tttatcgacg ggtgaaagaa tatgaacata ccttgcacca cttttcttga
     7801 tagatataac agctattaga cgggaaggga gagtttgaaa atggacttaa cgaatcaaag
     7861 ggtcgttttt actggaacgc tgcagcaaat gacacgaacc caagccatcg gtttggttca
     7921 ctctttaaac ggccattgtc aatcaagtgt tacttcaaaa acaaatttcc tggtttgtgg
     7981 tcagtattct aagtcgttgt ttgatgattc tctctataca aaaaaggaac aaaccgcgcg
     8041 ggacttgatt gcgttaggtc atgagattac cattttatca gaagtcgaat tttatgcgtt
     8101 aattagtcaa cagttgaaag aatggcaacg gtatttataa tcgttagtaa aatttacaag
     8161 gaggaaaatt tttatgaagc gaaaatctta tgatcgttgg ggcattgaaa taactagttt
     8221 taatcgaaat attgcttttc acgtggagtg tgactgtggg gaattagcaa aaagtgttta
     8281 tcaaaaaaat tacttttact gtcctaaatg ccatcgccga tacaaacaga aacaaggaga
     8341 atatgtagca attacaataa ttaaagaata aacaaataag atttacttca atgttggttt
     8401 ctgtttcata ctaaataaaa acctatttta atttagtaaa agggaattgg tttgcaagca
     8461 aaatcttccg ttttttgata gaattaagaa aaagttgaca acagatccta tttaaaaata
     8521 ggatgatttg cacttgaaat ttacttattg gaataagagg caatctgttt aatcgattga
     8581 ttgtgcgtag aaaatgaaca aaaaggtaag taacgaaagc cgttaaaaaa agagaaaaag
     8641 gacggtaaga aaattaaaga aaggaagatt tttatgccat taaccttaat actaggtgga
     8701 gaatatattt attatgataa aaatttaggc atgatggttg ccggggataa ttcaaatagt
     8761 gagttgatag aacaatcaga taacgtacca ttagacagac ataaatgtaa ggaacatgta
     8821 tttaaagaca aacgttttgt tgaaaaagaa agtgaatctt taactctatt aggctataaa
     8881 attgtagttg atactgttac tggtgtgaat tatttagaaa ctcctaaagg aggaattacg
     8941 cctctacttg ataaaaatgg taaaatctgc attgataaaa agaaatcaat aaataaaaaa
     9001 ggataaaaag atacatgtat ctttttatcc ttttttattt attttgagat taaatttttg
     9061 aggatacgtt gttcacgttc tgttaaatta ttttgtatat agctttctac agctttatca
     9121 ataaattcat aatttttgta gcttttcatt gttgatatgg ttttaattaa gtcaaaagta
     9181 gagggggaca ctttgatgtt ttttctttct gaagctaata tctttttact cgattttttt
     9241 tgaatagtaa cttttcgttt tgtatctgct tctttatttg ctgttgcccc ttgtgggatt
     9301 ttacgattta tcaaactaga catttagact aatctccttt cccagggaag ttaattttcc
     9361 gtctaatata tatctcggag tataaaaata atcttgaata tcaccattac ttttataaag
     9421 agtgatgcgt tcttctaatt cacagaaaat atctgcaaaa agagcaatca tttttttatc
     9481 atgatagtct tgaaattgaa atccaatccg tggataccac tctaaacgtg catgattttg
     9541 aataatagtg ttaaaaacat tgtctcttcc aaatgtgtct attgtttcct caactaattt
     9601 ttggtgcatt gggcgttttt gttgtaacaa tgcaggtaaa atgcctgcaa tttgaattgg
     9661 aacgtctgag ccaaaatcgt caactaaggt ttgtatataa tcaaaaatta gccgttgact
     9721 tccctcaaaa gaaaattgtt gtgtttcttg tactacaacc aagtaatcac atgcaaccat
     9781 agcattatct acctttaaat cggttgaagg tgggatgtca ataaaaatat aatcataatc
     9841 gtctttaatt tcttcaataa ggtttttaag ataaaaagtt ctatctattg tattatcaaa
     9901 attttctgtt aagaattcag tgtatagacg catatcataa ccagcgggaa ttaaatctaa
     9961 gttttcctta aggtttacga tagcaggacg tagatcgcca ttttcaagag cagacatcaa
    10021 agtctgaggt accgtttcta ccccaaatgt ttttgtcata aaatttgttg catttgcttg
    10081 caaatcaata tcaattaaaa tagtacgctt tttcattagc atcgcagcta ccaacgttat
    10141 catgcaagtg tcagttgttt ttcctacccc gcccttttgt tgtccaaata taattgtatt
    10201 agccatcaat atactccttc cttgtaatca aaatgtaata aaagataaat gtatctttgt
    10261 atcttttttc tatatttaaa tagtaataca aatagaatta attgtaaata gataaatgta
    10321 tcttttttct aattatctta aaacatactt atttaatcag atagcatttt ataagaaaag
    10381 ttattaaata gacttctaaa taaggataca aagataaaaa gataaaagga tacaaagata
    10441 aaaagataca acaataaaat taaaggataa aaagataaaa agataaaaag ataaaaggat
    10501 acaaagataa aaggatacaa aaataaatta agaatgatta tttgagagaa aatttttact
    10561 ttacaaaagt tgtagtgaca tgtattctaa agaagaattt gaatgaatag aaaaaagata
    10621 catttactaa ttgaattata gacaaaaaaa tagagacggt aacttagttg atttgccgat
    10681 caactaaatt acagaatcaa aatgtacaca gcatttcatg attctctttc gtcccattat
    10741 agttttagat tacagagagt tgcagctctc ttagtctttt taattatatc atttgggacc
    10801 ttaaaaatca agattttgag ctatatttta gctgcaaata aggtttaaag gagagctgta
    10861 gaatgcctgc agttctcctt tttttaaata tagaatgggt ggtgataaga tgaaagtttc
    10921 tgacgtgatt tcagttattt taaaaagtgg tattcgtgaa tacaagtgtt taaacagcaa
    10981 aattaaacca atcggctata aagctgaagg aaaaaaaggt gctatttttg ggtttagatc
    11041 caagaagtta atgacggaat ctcgtggaat cgttcttact tctcaagaag gcttagctga
    11101 aaatgaagat aaatttactc attggacacc taacgtttac agctatggtg catatgcaga
    11161 tgaaaaaaga ataattgtaa aagggcacaa cgaacgcaac ttgcaacaaa tcaatacttt
    11221 tgtaatcgat tttgatcgct taacaggcga aaaattagat tctcaaatga ttctcgatgc
    11281 agcaatcgat ctggaattaa tgccaaccct tattttggaa acaccagggg gcttccaagc
    11341 atactttatt cttgaaaatg cctggtatat ttcgtccaaa aataattatc agtcaatcga
    11401 agtggccaaa cgagtatctg agaacttaag aaaagcattt gctgaagaat tgccttcagt
    11461 cgatttaggt tgcaatcatt ttgggatagc acgtatccct agaactgaca acattgtcta
    11521 ttattatcca gctttaacac atgatataca gcaattaatc caatggtcaa tgaaatatga
    11581 gccagcgaaa acatataaaa aaccgctact ttcacttgtt aaaaataaat ataaacaagt
    11641 gaacgaaatg tggtatcgac aattaattag taatccaaaa attgtaggcg ctaaagggat
    11701 tatgggccgg aataatgtga ttttcacttt atctttggcc aattatgcat caggagttga
    11761 cttagaagac tgtctaaatg agatggatct ttttaacagt tctttagaac gtcctctaaa
    11821 agatagagaa cgagtaagaa ttgtaaaaag tgcttactct gggaagtata gaggtgcaag
    11881 taagacttat gtacaggagt tagtgtcaaa ttggggctta gaatcgctgt ctgaggaaaa
    11941 aatgtttaca caacaaagaa atacttggta caaatttaag aaggaacgtc ataaaagaaa
    12001 gaaatctcac ctttccgaat ggaaagaaga tattttagct taccttgaaa cccaatgtta
    12061 tagatacaga cctgaagtca gactgaagaa aacagatttg caagcagcga ttactttcaa
    12121 cggacaatca attcctaaac gttctcttga ccgtgcatta aaagaattga tggccgaagg
    12181 taaattattt gtacaaataa aagctggacg gaatggggga ctagtagttg ccactcgtaa
    12241 agcgttaatt cgtacggtca ttcaagtgaa gcaacaggta aaatctgcgt acaaacaggg
    12301 cattaagaca ttttttaaag aagccgatat gttagtaaga atcttcagag aaccggataa
    12361 atacagtcaa agagtagatc attataagca attaaatttg tggaatacag gataaaataa
    12421 aacatgtcaa gtgcctatac attatatttc ttttatactt gttttcgttt ttgttagtta
    12481 ttatcctaat tctgtatatt tttgtttttt tgggtattcg gattttatgg tggaaaaggg
    12541 cttataaatc acccttctcc aaattcttaa taggtgtgga aaaatcgaca ccaaagttgt
    12601 ctgtaatgtc gtgatcattc acttcatacc aattgaaagt atcgtataac atagctttat
    12661 tgaaagcact tgaattaaat cgtggcttac gctttttatg gagcttctca ttgaaaagga
    12721 ttttggctcg taaggcatca aacgagtaac ctctacccat tcgctctacc tgcctaataa
    12781 tgctgttaat tgactccgta taagcattag tgagcctttt atcaaagtag ttgaatattt
    12841 cgacatgcca gttgtctacg gctctcacga ggtctttata tgcgtcttta gagttgctgg
    12901 acatacaacg gtgtctccat tgactataac gaagatgacc ttcatctgga tcaggagtat
    12961 cccatatcca gtaaaactct tctttgagtt cataggcttc ttttaaagca ggaagattac
    13021 ctaaccaagt atctaagagg aatgattcac gttcatttaa atcgtgttta cgctttagaa
    13081 ggataaacct ttcacgcata agggtacgtc tttctttttg gctcatatgg gctttcaaag
    13141 acttcctgac gttatctaag gcttgattag ccattctaac tacatgaaac ttatctacga
    13201 caactttagc gtgtggaagg atagggttca ctgcgtcttt gtagggcttc cacatatcca
    13261 ttgtgacgta ctcaatgtaa gtcctgtcac tgatttctga aagacgttgg atgactgttt
    13321 ccttgttacg gttaggcttg atgtcataaa tagtcctgcg ttcaatatta gtcaatacaa
    13381 gccgaggtct acggataata tgtatctcgt ctatcccaag ccacttagga gtttcaaact
    13441 ggtattcacg ttctttgagt gccacatagt ccttaaaaac gttcctaatg gttttctcgt
    13501 caacaccaac gctttctgcg acttctacaa aggtcttaga catggattgc tcttgaatgg
    13561 actttaaaag ccttttggtc atactacgct tctcatctac agatattagg cgttcccaga
    13621 aggtagatcc gcattcacga cacttgtatc gtctacggtt caattgtaag cccactcgct
    13681 ttaaacgaat gggcaaatcc ataattagtt gatttcttga actgtgtttg tacaacttgt
    13741 caaaaccaca ttcaggacaa cgttcaggtg gtccgactgc ttcaacttta aacatcatat
    13801 cggtttcatt ttcttgtggc ggctctattg ttttaatgtc tggtagggat aataagtctg
    13861 acatattatt catcctttat tactctgcgg tgttaaggta tcaattatag atttgatgtc
    13921 gaaatcatca gtgttaaatt atttttgtga ccacaaatgc acttagaaaa tcccttaaag
    13981 cattagctgg ttcacttgaa tagggagttg taaaaaagtt cccttagcct gcacagcaag
    14041 ataatttcga aacatcttta tcaaaagtta ggacagccag cttcaatcct tctgccattg
    14101 ttagatatgg agccatcgtt tctctcagat ctccaacagt taaaccgaat ttcacagcta
    14161 atgttgctgc ataaattacg tctcctgcgt tttctgccac tacatgcgcc cctaacactt
    14221 tcaatgtttt cgcgtctgcc actaatttga aaacacctgt tgtttcccga ttaacgagcg
    14281 ctcttggaac agcatccaac ggcaataccg atgttttcac ttcatatcct ttttcttttg
    14341 cctgttgctc cgttaaacca accgttgcaa tcgatggaga agtaaacgta acgcctggaa
    14401 ccacttctaa attgaccttt tgatttagtc ctccgattgc attacgagca gcaagtccac
    14461 cttcataagc agctacataa acaaattggg gaccgagagt gacatctcca gctgaataaa
    14521 ttcgggaatt ggtcgtttta agataatcat caatgacaat ttcaccacgg gaaccaactt
    14581 caacgcctgc tgcatgtaag tttaatgatt ctgtatttgg ttttcttcca gtggcaatta
    14641 gcaattgttc tgcttcaata attcgctttt taccatttat ctcaacatga acttttttaa
    14701 tgtctccatc ttgctcaact cgttcatagg ttgcacctgt tactaaatta attccctgtt
    14761 ctgttaaggc cttagtaatg gcttctgaaa tttcaggatc gtattctttt aatagacgct
    14821 cgcttctttg aatcaaagtg acttctgacc cgaggttatg aaatagttgt cctaattcca
    14881 tgccgatata tcctgaacca attacggtaa gacgatttgg aaccttcttt aattccaata
    14941 agctagtgct tgttaaataa tctacttcat ctaatccggg aatattaggt gcagttgaag
    15001 aagcacctgt agctattaaa aatcttttgg ctgtgatttg attgccattt acttcaactg
    15061 tattttcatt tacgaatttt gcttcacctt ttattaattc aaaaccataa tcatcaatta
    15121 aattcacata tttttcattt cgcatctcgg ttactaaatc attcttttgt tttactaatg
    15181 gcgctaaatc aacatttgaa gccgaagtgt gtaatcccac aaatggatta ttttttgcta
    15241 gatgattgat ttcccctgct cttaataagg tcttagaagg aacgcatccg acattaacgc
    15301 aagttccacc caccgttcca cgctcaatca tagccacttt tgcgttcaaa gtaacggctt
    15361 caatggcaga tgaaaaggca gctccaccag aaccgatgat gatgtaatca taatcatagt
    15421 taccttcatc atttaaactt acatctgtcc ttttttccga ttgcacttgt atttcttctg
    15481 cttcgcccgg ttgatattgt gcgtcagtaa tcgctgtttt cgcgatatca atgtctacat
    15541 catacggtag ttcaaacagt gcttctccgc gacgaaagtc tacttcaatc ccttttgcac
    15601 ctgcattttc aagagcaacc gcaatatgtt cttcacaacc agtgcaggtc attccttcaa
    15661 cgtttagccg atattttttc aataaattcg tcttttgttc cgattgaaat tcttctgctt
    15721 cgcccgggtg atagtttgcg tcagcaatcg cctttattgc actttcaacc tcaatatcat
    15781 cgggcagttc aaatactgct tcaccacgac gataactaga ctcaatattt ttagcaccca
    15841 tcttttcaag tgctgattct acgtgttttt cacaacccgt acaagtcatt cctgaaatgt
    15901 ttaccttaaa tttattcata aaaaagctcc tttcgttaat taatctctca tgttaatgtt
    15961 tctattattg gacacgaatg taattgcttt tcatctggac atcgttgttt taagtcgtct
    16021 aacatagttt caattcgttt taaatcctct atttgttttt gcacttcctt ttgtttttta
    16081 gaaacaaatt cgaacatatc ttgacaacga acttcatctt tatctacaac accaagtaat
    16141 ttataaatct cgcttaaaga aaaaccaagt tcctgtattc gtttaataaa cccaacacgc
    16201 ttaacgtcat catatgaata tatccgataa ccagcttccg ttcggtgagg ttcttgtaat
    16261 aaattttttc gctcgtaata tctgatcgtt tctttattaa ctccacattt atctgcaaac
    16321 tcactaatgc gataaatcat cttatttcac cccatgaata ttataaaccg tgtaccatag
    16381 tacacgttca agtaaattgg actattttat ttttttccca aagtatcact cgtatgtgat
    16441 tgatactttt atataatact attgattatc ctaacatccc accagaaaat ccgatttaaa
    16501 caccagttgt ttttaaacta ttaagaaagt aattccacta tatattccga agacccgttt
    16561 tttttacagt ataattaagc taagtgttgc tagaacaatc agataagaaa ttgaataggg
    16621 gtgttttttt gaaaagaact tggggaaaga atttaacaat tcttatgtta ggaataatta
    16681 ttactggttg tggggaaaag tctcaagaaa cagcaaaaga aaccaaagct tatacttttg
    16741 ctgtttctac tacagtacaa agcttagatc cgaagttagc tatcgaccct acaagccaac
    16801 ttgttttaaa taacgtaatg gaaggattat ataaacttaa tgctaaaggt gaaattgtac
    16861 ctggaggagc taatggcctt ccagaaatct ctaaggatgg acttaagtac gttattcgat
    16921 tgagaaagga tgcaatgtgg agtaatggta cgcctgttgt tgcagatgac tatgtttatt
    16981 cgtggaaaag aacgttaagt aatcaagatt caccaaatat tggttttttt gaatctatta
    17041 aaaatggtaa agaaataatc tcaggaacta tgaaaccaga taagttggga gtttatgcta
    17101 aggataagaa tactttggtt attaatttga gtacgccaat cccatatttc acttctatgc
    17161 taattaatac agcatttttt cctcaaaaac aggaagttgt tgaaaaagaa ggagatagat
    17221 atggtacgaa ctctgatagt gtgatttata atggacccta tatcggggta catggaacat
    17281 agaaacgaaa tagtgcggta gaaaagcgaa tgaatgtagt atatttctac aaatcattcg
    17341 ctttctttat tttataaata gttggtcgag agatcccgtt ttcttttgca atctctgcaa
    17401 ctggaatgcc ttgctttaac atgtccacca cggttttaaa aactaagcgt ttttgcggat
    17461 ctgttgagtt aatagaatac tcgattggtc gtcccttata tcggccggct ttttgagcca
    17521 ataatactcc ttgccgctga cgttcacgaa ttttctcacg ctcgttttgt gcaatataac
    17581 ttagcagtga taaaaacata tcgaacatag cggtatccag gagttcattt ccagtattaa
    17641 aatctaaaaa ctgtgcatct aatattttta acgctacttt tttctgtttc ataaaagcaa
    17701 ctgtattttt tatatcttca taatctcttc ctaaacgatc tagtgatgta acgatgacgc
    17761 aatcaccttc acggatataa tttagtaatt tttgaaactc aggacgctca gtatctttac
    17821 cactggcttt ttcttggaat aatttatcaa tgttaagtcc ttccatcatt gccaattgtc
    17881 gatccaaatt ttgatcttgt gaagatactc gaatatagcc aatttttccc ataaaaaact
    17941 cctttttaaa agtgatataa tttacatgta aaatttactt gtagttttac tgctatcata
    18001 gcatttttaa aaataaattt tatgtagact taaaatttac ttcatggagg gtttaaatgg
    18061 atgaaatcaa aagtaacaaa aaagcatttg gcatttattt aggagaacct agtacagaac
    18121 aattaaacca atttttttat ttgcatgaaa aagatttaga attgatggag actatacgac
    18181 gaccagctac tagattaggt tttgcactac agttagtctc actacgtttt ttaggaactt
    18241 ttatattaga tcttaccaat attccccaaa atgtattgag ttatgtagca actcaactaa
    18301 atattgatcc tggagaaatt atcggttctg ttgcaaagtt ttaaataaag aataaaatcc
    18361 cttacggtat ctatgattta atctgggatt cccaataata ccttgatttc agtacagacc
    18421 gaaaacccga agagagtgcc ttcttttcgg gttttcttat ataatcctcg gatggcttcc
    18481 atgcctttaa tcgtgggtga ggcagtgcgt aaacttcgat agaatttatt gcgtctcttt
    18541 actggacgat ggtcttgttc aatcaaatta ttcaggtatt taatggtacg atgttctgtc
    18601 ccttgataaa atccgtattc ttttagtttc ttaaaggcac tagcaattga tggtgcttta
    18661 tctgtgacta caaccttcgg ttcatcaaac tgcttcacta accgcttaag aaaagcatag
    18721 gctgcttgtg tgtcccgttt tttacgtaac caaatatcca aggttaaacc atctgcatcg
    18781 atggctcgat acaaataatg ccattttcct ttaattttga tgtacgtttc atccattttc
    18841 caggaataaa aggatttttt atttttcttt ttccaaattt gatagagtag tttgccatat
    18901 tcttgcaccc aacgataaat cgtcgtatga gaaacgttaa tgccacgatc atataagatt
    18961 tcttgaactt cacgatagct aaggttataa cgaagatagt agcccacggc tacaataatc
    19021 acatcctgct gaaattgctt tcctttaaaa tgattcatcg tcattcctcc tgctatcttt
    19081 ttctattatt ctaccttatt tgatagtaga tttaaaactt tgcaacagaa ccgtctagtg
    19141 tgttatactt tacatggaag ttgtaccgaa atattgtgtt gtgaagtcta tataatttta
    19201 aaattatgaa gtctatatac gtgcgtaaag atatttaaag agattaaaaa taata
//
