LOCUS       CP063601               26310 bp    DNA     circular BCT 04-APR-2022
DEFINITION  Enterococcus faecium strain BMT-3-2-1 plasmid pHJB-2-1_03, complete
            sequence.
ACCESSION   CP063601
VERSION     CP063601.1
DBLINK      BioProject: PRJNA669626
            BioSample: SAMN16483157
KEYWORDS    .
SOURCE      Enterococcus faecium
  ORGANISM  Enterococcus faecium
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 26310)
  AUTHORS   Both,A., Kruse,F., Mirwald,N., Franke,G., Christner,M., Huang,J.,
            Hansen,J.L., Kroger,N., Berneking,L., Lellek,H., Aepfelbacher,M. and
            Rohde,H.
  TITLE     Population dynamics in colonizing vancomycin-resistant Enterococcus
            faecium isolated from immunosuppressed patients
  JOURNAL   J Glob Antimicrob Resist 28, 267-273 (2022)
   PUBMED   35134550
REFERENCE   2  (bases 1 to 26310)
  AUTHORS   Both,A., Kruse,F., Christner,M., Huang,J., Mirwald,N., Franke,G. and
            Rohde,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-OCT-2020) Institute of Medical Microbiology, Virology
            and Hygiene, University Medical Center Hamburg-Eppendorf,
            Martinistr. 52, Hamburg, Hamburg 20246, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Trycycler v. v0.3.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 479.5x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 10/27/2020 18:05:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.13
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 3,214
            CDSs (total)                      :: 3,122
            Genes (coding)                    :: 3,008
            CDSs (with protein)               :: 3,008
            Genes (RNA)                       :: 92
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 114
            CDSs (without protein)            :: 114
            Pseudo Genes (ambiguous residues) :: 0 of 114
            Pseudo Genes (frameshifted)       :: 39 of 114
            Pseudo Genes (incomplete)         :: 69 of 114
            Pseudo Genes (internal stop)      :: 15 of 114
            Pseudo Genes (multiple problems)  :: 8 of 114
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..26310
                     /organism="Enterococcus faecium"
                     /mol_type="genomic DNA"
                     /strain="BMT-3-2-1"
                     /isolation_source="rectal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1352"
                     /plasmid="pHJB-2-1_03"
                     /geo_loc_name="Germany: Hamburg"
                     /lat_lon="53.33 N 10.1 E"
                     /collection_date="2015-02-03"
                     /collected_by="Institute of Medical Microbiology, Virology
                     and Hygiene, University Medical Center Hamburg-Eppendorf"
     gene            1..1086
                     /locus_tag="IQN09_15775"
     CDS             1..1086
                     /locus_tag="IQN09_15775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002352763.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="UOC42557.1"
                     /translation="MSTEIQSQKMIIKNWGYKATNVYIEKYYKFPSFLIQNSKYSKMKD
                     SSKIAYMLFKNEFRRALHEKWIDDDGLLYLEFTQADLMDKLNCYQGKVKTILNELETYN
                     LISVVKGEFNPKTKKNEKNKYYLLQPEISADDLFIQNSFDDDLSQTIDKSTSSRNAEIA
                     RREETAKTLDNTGNAEIARREKTAETLDNTGNAEIAQDYYINKSLDTKRHLKDTETDQL
                     QNQVLLDNFVEIMKEDSINTFVPEKVLSLIKTFSNTYEEAQQTVTTIHNAKHKAEELEK
                     TVVVYEELESYGIDADKGLYMTLLKAYQKQKTEKVNNLQNLIFVYVKNWFIEKAIAAKL
                     ANEQRETFNELPTVSTENWLE"
                     /name="replication initiator protein A"
     gene            complement(1879..3174)
                     /locus_tag="IQN09_15780"
     CDS             complement(1879..3174)
                     /locus_tag="IQN09_15780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002297185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3-like element ISEfa5 family transposase"
                     /protein_id="UOC42558.1"
                     /translation="MNDSIKKMLRLIEKDLMITEVSYETFQKKKTLIVDAVFSPAPHTC
                     RNCGSTVVDGNGKVIVVKNGKKETIVRFEQYNHMPLVMRLKKQRYTCKNCRTHWTAQSY
                     FVQPRHSIANHVRYKIASLLTEKVSLSFIAKNCQVSLTTVIRTLKEFKSYLPKQSKRIL
                     PRVLMVDEFRSHASIEDKMSFICADGETGQLIDVLPTRKLPRLTSYFLGCANPEEVKFL
                     VTDMNAAYFQLTKRILPNAKVVIDRFHIIKHMNQAFNELRIREMNELRKVGQKSQAEKL
                     KKNWRFLLKNRANINHYEYKTWKSFRAPKYPFLTEAMMIDRLLGFSTSLKEAYPYFHEL
                     VEAFRDKDPDLFFSLLAELPETLDDGFREKLQNLLTYEEGITNAMIYPYTNGKIEAKNT
                     HIKTMKRVSYGFKSFENMRIRIFLINQLIKVR"
                     /name="ISL3-like element ISEfa5 family transposase"
     gene            3445..3777
                     /locus_tag="IQN09_15785"
     CDS             3445..3777
                     /locus_tag="IQN09_15785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002310954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein TraE"
                     /protein_id="UOC42559.1"
                     /translation="MSYTGILSLEDICHYGKRCTATEKITKKLSTGQNKTVVQCKKYII
                     QKDKVSEEMIYYVGKQKQIILKDPIPLKELYPTIKHVYDQNGVLIGRRKNGVLRCTAKG
                     MGRLIS"
                     /name="conjugal transfer protein TraE"
     gene            complement(4121..4801)
                     /locus_tag="IQN09_15790"
     CDS             complement(4121..4801)
                     /locus_tag="IQN09_15790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="UOC42560.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            complement(4877..5023)
                     /locus_tag="IQN09_15795"
                     /pseudo=""
     CDS             complement(4877..5023)
                     /locus_tag="IQN09_15795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010625604.1"
                     /note="incomplete; partial on complete genome; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /name="replication initiation protein"
     gene            5660..5746
                     /locus_tag="IQN09_15800"
     CDS             5660..5746
                     /locus_tag="IQN09_15800"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017548328.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="UOC42571.1"
                     /translation="MFELFICPLLIEVCVSLFSYWLNNRNKK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(5867..6556)
                     /locus_tag="IQN09_15805"
     CDS             complement(5867..6556)
                     /locus_tag="IQN09_15805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002298772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC42561.1"
                     /translation="MAFYLPYLLIFASILGIIWLSYKAYQTRYSLKGSKIRFKRFLLPG
                     VIFTLSIVLSGLFGVLEGNKRISRSILLGDITQKYEAACDKKKKEQVLTQKMEEFTTCY
                     EEMNDIFVNQEKRLTDKNMEKLTRLYQNLPEKQQKEVQDNYERTKKDVQYFKDTQTEEA
                     CYNLFSDTIPFSTSEQERKERQQSVTYERYKALLQQATNIQNPTKKETALNYLKSVKEW
                     LDQQQQN"
                     /name="hypothetical protein"
     gene            complement(6801..7715)
                     /locus_tag="IQN09_15810"
     CDS             complement(6801..7715)
                     /locus_tag="IQN09_15810"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002340563.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="relaxase/mobilization nuclease domain-containing
                     protein"
                     /protein_id="UOC42562.1"
                     /translation="MATVKVSRTTSCSRAINYAEPRATVKTGINCDIDYAKSEMKQIRM
                     LYGKDDRVQAHLLIQSFRPGEITAEKANQLGAEYAKKIAPDHQIAIYTHTDKDHIHNHI
                     VINSVNLETGNKFQAHGQAFLNKCYDLNDEICLEHDLTITERGKKPEKRTMSEIKLKEK
                     NEPVWKDEIRFAIDQTMKNKKTRTYNQFCDSLKTFGIHCLNRGKNFTYELIHKKKKVRS
                     NKLGKDYEKETILHELDRRERAYNQQRTNELRRARASIRETAKEVRREQRTLTTEQPEI
                     RPTRRNHDQHVERGADYQQELSF"
                     /name="relaxase/mobilization nuclease domain-containing
                     protein"
     gene            complement(7697..8077)
                     /locus_tag="IQN09_15815"
     CDS             complement(7697..8077)
                     /locus_tag="IQN09_15815"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002348702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family plasmid mobilization relaxosome
                     protein"
                     /protein_id="UOC42563.1"
                     /translation="MSEQNQYLASNHSKKYTYRSEPKQISFRVSESEFAKLKQSAEALQ
                     MSVPAFVKAKAQNARLVTPKVAPDIAQAIARDLAKAGGNINQIAKWCNTHQHDVDPGDA
                     QRLSENLKIMQKELQKIWQQLK"
                     /name="MobC family plasmid mobilization relaxosome protein"
     gene            complement(8528..8815)
                     /locus_tag="IQN09_15820"
     CDS             complement(8528..8815)
                     /locus_tag="IQN09_15820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002363589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin immunity protein"
                     /protein_id="UOC42564.1"
                     /translation="MDFTKEEKLLNAISKVYNEATIDDYPDLKEKLFLYSKEISEGKSV
                     GEVSMKLSSFLGRYILKHKFGLPKSLIELQEIVSKESQVYRGWASIGIWS"
                     /name="bacteriocin immunity protein"
     gene            complement(8835..9059)
                     /locus_tag="IQN09_15825"
     CDS             complement(8835..9059)
                     /locus_tag="IQN09_15825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002363584.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin hiracin-JM79"
                     /protein_id="UOC42565.1"
                     /translation="MKKKVLKHCVILGILGTCLAGIGTGIKVDAATYYGNGLYCNKEKC
                     WVDWNQAKGEIGKIIVNGWVNHGPWAPRR"
                     /name="bacteriocin hiracin-JM79"
     gene            complement(9514..9684)
                     /locus_tag="IQN09_15830"
     CDS             complement(9514..9684)
                     /locus_tag="IQN09_15830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002322958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC42566.1"
                     /translation="MTKKHLLFGSILLGILSFSPMLLSVANKGNKKGELKLNPNYYNSQ
                     NEEVFVEKLDK"
                     /name="hypothetical protein"
     gene            complement(9699..10232)
                     /locus_tag="IQN09_15835"
     CDS             complement(9699..10232)
                     /locus_tag="IQN09_15835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002292473.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="UOC42567.1"
                     /translation="MQPQETFTIKELSDLFKMSRQAISKHIQKLDSSMIAKNERGYKVV
                     LRSGVLQLARNLDNQRLLDKLHKHEQNNDKNAYIPNKNVVANKLLDQLREENEFLREQL
                     ALKEQNNSHIQKLLDQQQQLTLQANQQIEKLQEQLQLTYTEESSENSSTTLSEATETMD
                     EQTKNWKKWWQLWK"
                     /name="DUF536 domain-containing protein"
     gene            complement(10253..10699)
                     /locus_tag="IQN09_15840"
                     /pseudo=""
     CDS             complement(10253..10699)
                     /locus_tag="IQN09_15840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002303559.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="initiator RepB protein"
                     /name="initiator RepB protein"
     gene            complement(10755..11435)
                     /locus_tag="IQN09_15845"
     CDS             complement(10755..11435)
                     /locus_tag="IQN09_15845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="UOC42568.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            11724..12419
                     /gene="vanR"
                     /locus_tag="IQN09_15850"
     CDS             11724..12419
                     /gene="vanR"
                     /locus_tag="IQN09_15850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001280781.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanA-type vancomycin resistance DNA-binding
                     response regulator VanR"
                     /protein_id="UOC42569.1"
                     /translation="MSDKILIVDDEHEIADLVELYLKNENYTVFKYYTAKEALECIDKS
                     EIDLAILDIMLPGTSGLTICQKIRDKHTYPIIMLTGKDTEVDKITGLTIGADDYITKPF
                     RPLELIARVKAQLRRYKKFSGVKEQNENVIVHSGLVINVNTHECYLNEKQLSLTPTEFS
                     ILRILCENKGNVVSSELLFHEIWGDEYFSKSNNTITVHIRHLREKMNDTIDNPKYIKTV
                     WGVGYKIEK"
                     /name="vanR"
     gene            12397..13551
                     /locus_tag="IQN09_15855"
     CDS             12397..13551
                     /locus_tag="IQN09_15855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002305818.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanA-type vancomycin resistance histidine kinase
                     VanS"
                     /protein_id="UOC42570.1"
                     /translation="MVIKLKNKKNDYSKLERKLYMYIVAIVVVAIVFVLYIRSMIRGKL
                     GDWILSILENKYDLNHLDAMKLYQYSIRNNIDIFIYVAIVISILILCRVMLSKFAKYFD
                     EINTGIDVLIQNEDKQIELSAEMDVMEQKLNTLKRTLEKREQDAKLAEQRKNDVVMYLA
                     HDIKTPLTSIIGYLSLLDEAPDMPVDQKAKYVHITLDKAYRLEQLIDEFFEITRYNLQT
                     ITLTKTHIDLYYMLVQMTDEFYPQLSAHGKQAVIHAPEDLTVSGDPDKLARVFNNILKN
                     AAAYSEDNSIIDITAGLSGDVVSIEFKNTGSIPKDKLAAIFEKFYRLDNARSSDTGGAG
                     LGLAIAKEIIVQHGGQIYAESNDNYTTFRVELPAMPDLVDKRRS"
                     /name="VanA-type vancomycin resistance histidine kinase
                     VanS"
     gene            13766..14734
                     /locus_tag="IQN09_15860"
     CDS             13766..14734
                     /locus_tag="IQN09_15860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001059542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-lactate dehydrogenase VanH-A"
                     /protein_id="UOC42542.1"
                     /translation="MNNIGITVYGCEQDEADAFHALSPRFGVMATIINANVSESNAKSA
                     PFNQCISVGHKSEISASILLALKRAGVKYISTRSIGCNHIDTTAAKRMGITVDNVAYSP
                     DSVADYTMMLILMAVRNVKSIVRSVEKHDFRLDSDRGKVLSDMTVGVVGTGQIGKAVIE
                     RLRGFGCKVLAYSRSRSIEVNYVPFDELLQNSDIVTLHVPLNTDTHYIISHEQIQRMKQ
                     GAFLINTGRGPLVDTYELVKALENGKLGGAALDVLEGEEEFFYSDCTQKPIDNQFLLKL
                     QRMPNVIITPHTAYYTEQALRDTVEKTIKNCLDFERRQEHE"
                     /name="D-lactate dehydrogenase VanH-A"
     ARG             14710..15758
                     /name="vanA"
                     /gene="vanA"
                     /gene_name="glycopeptide resistance gene cluster; Van
                     ligase"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="99.71"
                     /coverage="101.75"
     ARG             14728..15755
                     /name="vanA"
                     /gene="vanA"
                     /gene_name="D-alanine--(R)-lactate ligase VanA"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="99.71"
                     /coverage="100.0"
     gene            15764..16372
                     /locus_tag="IQN09_15870"
     CDS             15764..16372
                     /locus_tag="IQN09_15870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000402347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-Ala-D-Ala dipeptidase VanX-A"
                     /protein_id="UOC42544.1"
                     /translation="MEIGFTFLDEIVHGVRWDAKYATWDNFTGKPVDGYEVNRIVGTYE
                     LAESLLKAKELAATQGYGLLLWDGYRPKRAVNCFMQWAAQPENNLTKESYYPNIDRTEM
                     ISKGYVASKSSHSRGSAIDLTLYRLDTGELVPMGSRFDFMDERSHHAANGISCNEAQNR
                     RRLRSIMENSGFEAYSLEWWHYVLRDEPYPNSYFDFPVK"
                     /name="D-Ala-D-Ala dipeptidase VanX-A"
     gene            16778..17710
                     /gene="vanY"
                     /locus_tag="IQN09_15875"
     CDS             16778..17710
                     /gene="vanY"
                     /locus_tag="IQN09_15875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanY-A/VanY-F/VanY-M family D-Ala-D-Ala
                     carboxypeptidase"
                     /protein_id="UOC42572.1"
                     /translation="MVKEETENEEVVFLLLLLFLIYLGYDYVNEALFSQEKVEFQNYDQ
                     NPKEHLENSGTSENTQEKTITEEQVYQGNLLLINSKYPVRQESVKSDIVNLSKHDELIN
                     GYGLLDSNIYMSKEIAQKFSEMVNDAVKGGVSHFIINSGYRDFDEQSVLYQEMGAEYAL
                     PAGYSEHNSGLSLDVGSSLTKMERAPEGKWIEENAWKYGFILRYPEDKTELTGIQYEPW
                     HIRYVGLPHSAIMKEKNFVLEEYMDYLKEEKTISVSVNGEKYEIFYYPVTKNTTIHVPT
                     NLRYEISGNNIDGVIVTVFPGSTHTNSRR"
                     /name="vanY"
     gene            17863..18348
                     /gene="vanZ"
                     /locus_tag="IQN09_15880"
     CDS             17863..18348
                     /gene="vanZ"
                     /locus_tag="IQN09_15880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000516404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycopeptide resistance protein VanZ-A"
                     /protein_id="UOC42545.1"
                     /translation="MGKILSRGLLALYLVTLIWLVLFKLQYNILSVFNYHQRSLNLTPF
                     TATGNFREMIDNVIIFIPFGLLLNVNFKEIGFLPKFAFVLVLSLTFEIIQFIFAIGATD
                     ITDVITNTVGGFLGLKLYGLSNKHMNQKKLDRVIIFVGILLLVLLLVYRTHLRINYV"
                     /name="vanZ"
     gene            18509..19189
                     /locus_tag="IQN09_15885"
     CDS             18509..19189
                     /locus_tag="IQN09_15885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="UOC42546.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            19672..20493
                     /locus_tag="IQN09_15890"
     CDS             19672..20493
                     /locus_tag="IQN09_15890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812603.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
                     /protein_id="UOC42547.1"
                     /translation="MYQFLKTGATILNYYQQYKENKKRCGRRSIALPEEQKEYVQKRVV
                     QGWTPDVIVGRSEMKLDCSVRTLYRMFQTGAFNVRDLPMKGKRKPNGHQEKRGKQAFRR
                     SIHERIKEHPEFENEFGHLEGDTIVGRKHKSAVITLVERLSKVIITLKPAGRQAMDIEN
                     RINHWFQTVPKHLFKSITFDCGKEFSNWKAMGNQNDIDIYFADPGTPSQRALNEHSNGL
                     LRRDGLVKAMDFNEVSESFIEYRKHFLYSILSSFKFSIDYIYCEFCRGSET"
                     /name="IS30 family transposase"
     gene            20580..21185
                     /locus_tag="IQN09_15895"
     CDS             20580..21185
                     /locus_tag="IQN09_15895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016176895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fic family protein"
                     /protein_id="UOC42548.1"
                     /translation="MILENKLGLTNQVELAKAEEKLSKQKAKELYDSGKINEIEVGTFK
                     GLSEIHDFLFSEIYDFAGKIRTVNIAKGNFRFAPVMYLEQSLNHIDQMPQTSFEEIIKK
                     YVEMNIAHPFREGNGRSTRIWLDLILKEELQKVVDWNLIDKADYLSAMERSPINDLEIR
                     YLISNALTDKIDDRELYMKGIDVSYFYEGYSEYTIDDL"
                     /name="Fic family protein"
     gene            21201..21776
                     /locus_tag="IQN09_15900"
     CDS             21201..21776
                     /locus_tag="IQN09_15900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002300096.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="UOC42549.1"
                     /translation="MTKYGYARVSTASQSTKEQIQQLLENGVEKKNIFSEKFTGTKRDR
                     PKFNQLLAGLKPGDEIVVTKLDRFARNTREALEIIEPLLDDNVTIKVLNLGTIENTSMG
                     RMVTRTLLSVAEMDRDMIVERTQEGKLFAKKNNPNFKEGRPKATITPKKRHAYELITSG
                     KSYKEVEAITGFSRSTLFRIKKQIEASE"
                     /name="recombinase family protein"
     gene            21936..22139
                     /locus_tag="IQN09_15905"
     CDS             21936..22139
                     /locus_tag="IQN09_15905"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002300097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA helicase UvrA"
                     /protein_id="UOC42550.1"
                     /translation="MKEQQLGYTLWGRPLYGLERRTAVSIDCACGELIQLNIQTKQYNC
                     KNCGNCYQFIDQDFQLLNEKNK"
                     /name="DNA helicase UvrA"
     gene            22248..23573
                     /locus_tag="IQN09_15910"
     CDS             22248..23573
                     /locus_tag="IQN09_15910"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002335330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Y-family DNA polymerase"
                     /protein_id="UOC42551.1"
                     /translation="MLDYSKEPVNDYFLIDMKSFYASVECIERNLDPLTTELVVMSRAD
                     NTGSGLILASSPAAKKKYGISNVSRPRDLPQPFPKTLHVVPPRMNLYIKRNMQVNNIFR
                     RYVADEDLLIYSIDESILKVTRSLNLFTTEGTRSQRRKNLAQMIQERIKEELGLIATVG
                     VGDNPLLAKLALDNEAKHNEGFIAEWTYENVPEKVWNIPEMTDFWGIGSRMKKRLNQMG
                     ILSIRDLANWNPYTIKNRLGVIGLQLYFHANGIDRTDIAIPPEPTKEKSYGNSQVLPRD
                     YTRRNEIELVVKEMAEQVAIRIRQHNCKTGCVHLNIGTSILETRPGFSHQMKIPITDNT
                     KELQNYCLFLFDKYYEGQEVRHVGITYSKLVYTDSLQLDLFSNPQKQIDDEKLDKIIDK
                     IRQKYGFTSIVHASSMLEGARSITRSTLVGGHAGGAGELKND"
                     /name="Y-family DNA polymerase"
     gene            23566..23916
                     /locus_tag="IQN09_15915"
     CDS             23566..23916
                     /locus_tag="IQN09_15915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002359653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC42552.1"
                     /translation="MIDYNDRGRLKWVGFYLSDHTEEIDADNEQRANNNLAKEQMTTEE
                     ISEVLNAAVIKNRSVCIQKEERNAEGYYPDDIVGKILGSDELGIYVGKYKIHYDEIRHI
                     EFYQDNKWSRLE"
                     /name="hypothetical protein"
     gene            23913..24092
                     /locus_tag="IQN09_15920"
     CDS             23913..24092
                     /locus_tag="IQN09_15920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001021554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC42553.1"
                     /translation="MNIIQQYELKYITFDQLSEEIWGYGQRLINEVGVERFSFYVEVAA
                     GYHNFRFYIFPLFI"
                     /name="hypothetical protein"
     gene            24228..24521
                     /locus_tag="IQN09_15925"
     CDS             24228..24521
                     /locus_tag="IQN09_15925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002352765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type III secretion system protein PrgN"
                     /protein_id="UOC42554.1"
                     /translation="MSINTFVYSHPINVYIIKNLGITVEQFCELYAYPQGTVASWITRQ
                     RRIKSLPASFVYDLSLASSMNMTDVYEKLLILENEYDQFTSNQQRKVKKQID"
                     /name="type III secretion system protein PrgN"
     gene            24747..25565
                     /locus_tag="IQN09_15930"
     CDS             24747..25565
                     /locus_tag="IQN09_15930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002305212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family protein"
                     /protein_id="UOC42555.1"
                     /translation="MDTFQGTTFTVGNFKGGVGKTKIVSMLAYDNAMIRNRKTLIIDLD
                     PQANLTQVIARTFGITDIKTTITNGVANGELASSIIKVNENLDLLACDTSFRSFSAFAN
                     KHENELDQVTVLKKLLLPIKNNYQEIFIDVPPTISEFSDNAMAASDYSIISFQTAEESL
                     EGVNKYVNYQKFMVDRYDLDLQIIDIVPCMVEPNDDFDEEILEEAIEKYGTVVSKNLIH
                     YQKRLRRYSKIGIHLRKYKNGNFDQWDYKAHQVFINILAELDARQEFLNK"
                     /name="ParA family protein"
     gene            25584..25991
                     /locus_tag="IQN09_15935"
     CDS             25584..25991
                     /locus_tag="IQN09_15935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002305214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC42556.1"
                     /translation="MPKDFDIPKMMENGEFEPLLPNNKRQDVKISGEYNFSNSALSNTK
                     NITLKKRGRPVSIPDKRNKVSVPKKISPALNSKLSILQDYMTELQSEKGRISFEKIVNT
                     LADSYIQHRLGVAKEEHIREEIQEEFEKLPK"
                     /name="hypothetical protein"
     ARG             13767..14731
                     /name="vanH-A"
                     /gene="vanH-A"
                     /gene_name="D-lactate dehydrogenase VanH-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             17864..18345
                     /name="vanZ-A"
                     /gene="vanZ-A"
                     /gene_name="glycopeptide resistance protein VanZ-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             12398..13548
                     /name="vanS-A"
                     /gene="vanS-A"
                     /gene_name="vancomycin resistance histidine kinase VanS-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             11725..12416
                     /name="vanR-A"
                     /gene="vanR-A"
                     /gene_name="vancomycin resistance response regulator
                     transcription factor VanR-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             16803..17707
                     /name="vanY-A"
                     /gene="vanY-A"
                     /gene_name="D-Ala-D-Ala carboxypeptidase VanY-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="98.68"
                     /coverage="99.67"
     ARG             15765..16369
                     /name="vanX-A"
                     /gene="vanX-A"
                     /gene_name="D-Ala-D-Ala dipeptidase VanX-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             13767..14734
                     /name="vanH gene in vanA cluster"
                     /gene="vanH gene in vanA cluster"
                     /gene_name="vanH; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             11725..12419
                     /name="vanR gene in vanA cluster"
                     /gene="vanR gene in vanA cluster"
                     /gene_name="glycopeptide resistance gene cluster; vanR"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             16731..17710
                     /name="vanY gene in vanA cluster"
                     /gene="vanY gene in vanA cluster"
                     /gene_name="vanY; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="98.68"
                     /coverage="107.59"
     ARG             17864..18348
                     /name="vanZ gene in vanA cluster"
                     /gene="vanZ gene in vanA cluster"
                     /gene_name="vanZ; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             12398..13552
                     /name="vanS gene in vanA cluster"
                     /gene="vanS gene in vanA cluster"
                     /gene_name="vanS; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="100.0"
                     /coverage="94.79"
     ARG             15765..16372
                     /name="vanX gene in vanA cluster"
                     /gene="vanX gene in vanA cluster"
                     /gene_name="vanX; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     BGC             3835..14059
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          680..1086
                     /name="rep_cluster_889"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(6805..7715)
                     /name="MOBP"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="93.421"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 atgtctacag aaattcaatc tcaaaaaatg attattaaaa attggggata taaagcaacg
       61 aatgtttata ttgaaaaata ttataaattt cctagttttt taattcagaa ttctaaatac
      121 tctaaaatga aagacagctc aaaaatagcc tatatgcttt ttaaaaatga atttcgtaga
      181 gccttacatg aaaaatggat cgacgatgat ggtctattat atttggaatt tacacaagca
      241 gacctaatgg acaaattaaa ttgctaccaa ggcaaagtaa aaaccatttt aaacgagtta
      301 gaaacatata atttgatttc agtcgtaaaa ggagaattta acccaaaaac gaaaaaaaat
      361 gaaaaaaata aatactattt acttcaacct gaaataagtg ccgatgatct ttttattcag
      421 aattctttcg atgacgattt aagccaaact attgataaat caacctcttc tcggaatgcg
      481 gaaatcgcac gtcgagagga aactgctaaa acccttgata atactggaaa tgcggaaatc
      541 gcacgtcgag aaaaaacagc tgaaaccctt gataacactg gaaatgcgga aatcgcacaa
      601 gattattata ttaataaatc tttagacact aaaagacact taaaagacac tgaaacagac
      661 caattacaaa atcaagtttt gctagataac ttcgttgaaa tcatgaaaga agacagcata
      721 aacacatttg taccagaaaa ggtattaagc ttgataaaaa cattttctaa cacttacgaa
      781 gaagcccaac aaaccgtcac cacaatacac aacgcaaaac ataaagccga ggaacttgag
      841 aagacggtag ttgtgtatga agaacttgaa tcttacggaa ttgatgcgga taaaggatta
      901 tatatgacgt tgctgaaagc ttatcaaaaa caaaagactg agaaagtaaa taatttgcag
      961 aatttgattt ttgtgtatgt aaaaaactgg tttattgaaa aagctattgc ggcaaagctt
     1021 gcaaacgaac aaagagaaac atttaacgaa ttaccaacag ttagtacgga aaattggcta
     1081 gagtagttga taaaaagcga tcactataaa aatgatcaat tttaaattag aactttttta
     1141 taattttaat tttattacaa atgttacaaa taaatagtta ttattccgga gtttttagat
     1201 taaaagttta tgaaaacaat cacaaacgta ggttttaatg tcataatcgt tagatatttt
     1261 agttattttt cattcaaaaa aaatagggaa ctagtgtttg catatgtgct tttttgagtt
     1321 ataataattc atgaagagag gtaattcact tatttcccca agctgaaaag cctgatatta
     1381 cttcttttca ggcagtgctg ctaatattca attacacttt tttgtatatt tttagttgtt
     1441 ttaaatttaa ttgtctgcta tgcttgtgat gaattgattt tcgttctgca cttttggacg
     1501 ataaatttgg acaattgaaa atacaaaaaa aagaaaggcc cctgtaagac tcgggagact
     1561 ggtaatctcc gtcagtgccc tacaggaaag cattaagctc actccttaat gcgtgccctt
     1621 cagtgttacg gtattacccg caacggattt agtataacag atattcaaaa gtgataccac
     1681 tttttttggc tgtgttaagg ttaaaaatac gtgatattac gatgaatcta tgcctaagca
     1741 taatgttata aaaatgtccg tgtggctctt tgccgtatga tgaacgctga aattagggct
     1801 ctttgtcaat aaggactgat gggttgtaca aaatcaaatc tgggtcagaa tgaacctcat
     1861 tctggctcag attttttgtt atcttacttt gattaattga ttgatcaaaa agattctaat
     1921 tctcatgttc tcaaatgatt taaatccgta ggatactcgt ttcattgtct ttatatgggt
     1981 attcttcgct tctatttttc cattggtgta aggatagatc atcgcgttgg tgatgccttc
     2041 ttcataggtc agaaggtttt ggagcttttc ccgaaagccg tcatctaacg tttcgggaag
     2101 ttctgccaat aaggagaaaa ataagtcagg gtctttgtct cgaaaggctt caactaattc
     2161 atgaaaatag ggatacgcct ccttcaggga cgtagaaaag ccaagcaatc gatcaatcat
     2221 catcgcttcc gtaagaaatg ggtattttgg tgctcgaaaa cttttccatg ttttgtattc
     2281 ataatggttg atgtttgcac gattttttag caaaaagcgc cagttctttt tcagtttttc
     2341 tgcctgactt ttctgtccta ctttacgaag ttcattcatt tcacggatac gcaactcatt
     2401 aaaggcttga ttcatgtgtt tgataatatg aaaccgatca atcactactt tcgcatttgg
     2461 cagaatacgt ttggtaagct ggaagtaggc ggcgttcatg tctgtgacta aaaattttac
     2521 ttcttcagga ttagcgcagc ctaagaaata gcttgttaat cgaggcaatt tacgcgtagg
     2581 caagacatca attaattgtc ctgtttcgcc atctgcgcaa ataaagctca ttttatcttc
     2641 tatggaagcg tgcgaacgaa attcatcaac catcaatact ctggggagaa tcctcttaga
     2701 ttgctttggt aagtagcttt taaactcttt caacgtacga ataacggtgg tcaaagatac
     2761 ctgacaattt ttcgcaataa aagataaaga tactttttca gtcagtaaag aagcaatttt
     2821 atatctgaca tgattcgcga ttgaatgtct gggttgaaca aaataacttt gagccgtcca
     2881 atgggttcga cagtttttac aggtatagcg ctgctttttt aagcgcataa ccaaaggcat
     2941 gtgattgtat tgttcaaagc ggacaatcgt ttccttcttc ccatttttca ctacaattac
     3001 tttcccgttt ccatctacca cagtagaacc acaatttcta caggtatggg gagcaggtga
     3061 gaaaacagca tcgacgatca acgtcttttt cttctgaaag gtctcgtaag agacctctgt
     3121 aatcatcaaa tctttctcta ttaatcgcag catttttttg atagaatcat tcatatagca
     3181 tatcgtcctc tcagttgttt attttgtcgt gatttaatca tactagagaa cgatatgttt
     3241 tttaatacct aaaataaaaa tggggctgaa gaatcaattc tgattcatca gtcccataaa
     3301 ttatagagcc gaaattagag ggaacgcatg tttggatgcg ttccctcttt tttgtttgtc
     3361 atgaacgaaa atcaattctc tatttttgaa aaataacaag aaaaacttgt taaaaatatt
     3421 taaagtaagt gggtggatta ttttatgtca tatacaggaa ttttgagtct cgaagatatt
     3481 tgtcactacg gtaaacggtg taccgctaca gagaagatca cgaagaaact atcaactggc
     3541 caaaataaaa ccgttgtgca gtgtaagaaa tatataatcc aaaaagacaa agtctcagag
     3601 gaaatgattt attacgttgg gaaacaaaag caaataattt taaaagatcc tatcccttta
     3661 aaagagctat atccaacaat caaacatgtt tatgaccaaa acggtgtatt gataggtcga
     3721 agaaaaaatg gagtcttacg ttgtaccgca aaagggatgg ggcgtttgat cagctgaatt
     3781 gatcattctt ataacttgta ttttatcgtt tttcgcttgc ttgaaaatat tgtcgagact
     3841 tctaaaagaa cttagaatca ctagaaaaat aaggagtaga cttgatctat caacaattcc
     3901 cttcggggag tgatggggta ggtttttacg attggtaacg taaaaaattg gtcaatcgag
     3961 taaatgccct tgtttggata gtggtgaaat gaatttgtgt aaataatatg cacagagtaa
     4021 acaagaggga atttagaagt tagacaagtt agaatagcgc ctagatggtt ctgttgcaaa
     4081 gttttaaata aagaataaaa tcccttacgg tatctatgat ttaagctggg attcccaata
     4141 ataccttgat ttcagtacag accgaaaacc cgaagagagt gccttctttt cgggttttct
     4201 tatataatcc tcgaatggct tccatgcctt taatcgtggt agaggcagtg cgtaaacttc
     4261 gatagaattt attgcgtctc tttactggac gatggtcttg ttcaatcaaa ttattcaggt
     4321 atttaatggt acgatgttct gtcccttgat aaaagccgta ttcttttagt ttcttaaagg
     4381 cacttgtaat agagggggct ttatctgtga ctacaacctt cggttcatca aactgcttca
     4441 ctaaccgctt aagaaaagca taggctgctt gtgtgtcccg ttttttacgt aaccaaatat
     4501 ccaaggttaa accatctgca tcgatggctc gatacaaata atgccatttt cctttaattt
     4561 tgatgtacgt ttcatccatt ttccatgaat aaaaggattt tttatttttc tttttccaaa
     4621 tttgatagag tagtttgcca tattcttgca cccaacgata aatcgtcgta tgagaaacgt
     4681 taatgccacg atcatataag atttcttgaa cttcacgata gctaaggtta taacgaagat
     4741 agtagcccac ggctacaata atcacatcct gctgaaattg ctttccttta aaatgattca
     4801 tcgtcattcc tcctgctatc tttttctatt attctacctt atttgatagt agatttaaaa
     4861 ctttgcaaca gaaccgttgg tcaaacgtaa aacgaactgt cttatcccct ttttcacgca
     4921 ttctagacac gatggaaaaa aacaaattca tttcaaccgg tgtaaatttt cttaaaggaa
     4981 ttgtatttaa ttcatggtgg tattttacaa tctcattagc catataatca cctcaatcca
     5041 attatgaatg acatttttta aatgtcaaga cattcatatt tgacgttcaa acagacaaaa
     5101 tgtccttcat aaacagacaa aatgtccttc ataaacagac aaaatgtcct tcataaacag
     5161 acaaaatgtc cttcataaca ttctgtatcc attggtagag taaggacaca gcttacggta
     5221 aagaggttta aaaagaggtt taaaaagaga tataaaaaga ggggggctaa ttttcccgcc
     5281 taaaaaccac ttcttttttc tttaaacagg ttcgcgcatt tttcaaaact gccaatccaa
     5341 aaccttgctt cctacggtcg ccaaaaaggt gtgatcgcta cgctctcaca ttgtactgcg
     5401 cagtcgccta aaggctcctt tgctaaaaac atgttggtaa agaggccttt gagcggttct
     5461 gaatgcttat ctaagccgtt ttaagacagt cttggataaa aatccttatc tagctttaaa
     5521 gcgccttaca ggcggtcagg gcaagcccta acaaccctaa aataagcgat acttaaaaac
     5581 accacacaag tttaattttt taagatataa taacttgtcg cctatccgac agtcttgcga
     5641 ctggaaggag gtgtatctaa tgtttgaatt gttcatttgc ccccttctta tagaagtttg
     5701 tgtctcttta ttcagttatt ggttgaataa ccgaaacaag aagtaaaatc aataaaggcg
     5761 acatcaacct gaaaaaaagc cccagagaat ccaacctctc tggggctttc gtgtatctaa
     5821 tgtttgatca tttgcatgtt tagtttaaca tgattgccga tcaaattcaa ttttgctgtt
     5881 gctgatctaa ccattccttg acacttttta gataatttaa tgccgtttct tttttcgttg
     5941 gattttgtat gttcgttgct tgctgaagca gtgctttata acgttcgtag gtaactgatt
     6001 gttgccgttc ttttcgttcc tgttcactag ttgaaaaagg gattgtatca ctgaataaat
     6061 tataacaagc ttcttctgtc tgcgtatctt taaaatattg cacgtctttt ttggttcgct
     6121 catagttgtc ttgaacctct ttttgctgtt tttctggcaa gttttgataa agacgagtga
     6181 gtttttccat gtttttatcc gtcaaacgtt tttcttgatt cacaaaaata tcgttcattt
     6241 cctcataaca agtggtaaac tcttccattt tttgtgttaa cacttgctcc tttttctttt
     6301 tatcacatgc tgcttcatac ttttgagtga tatcccctaa taaaatactt cttgaaatac
     6361 gtttatttcc ctctaaaacg ccgaataaac cacttaaaac gattgataat gtaaatataa
     6421 cccctggcaa taaaaacctc ttaaatcgaa ttttagagcc ttttaatgaa tatcttgttt
     6481 gataagcctt atagctaagc caaataattc ctaaaatact ggcaaaaatg agtagatagg
     6541 gtaaatagaa tgccatttct atttattctc cccataccag ccaaaaggct aacagtgtca
     6601 tgattaagca acataagggg gcaagaatat ccattgatcg ctgcataatt acttttttct
     6661 gttctttatt tcgctggttt aatagcgcat ggtggaattt tttgacttgt gaatcaattg
     6721 tagtttgtat tctttctttg gtataaggtg caagaaaagc acgttgtttc tttatttcat
     6781 tttctatgtc ttgtaacgtt ttagaacgat aattcttgtt ggtagtctgc tcctctttca
     6841 acgtgttggt catggtttct tcgagtcggt ctaatttccg gttgttcagt cgtaagagtt
     6901 cgttgttctc ttcgtacttc ttttgcagtt tcgcgaatgc tagctcgagc tcttcgtagc
     6961 tcgttggttc gttgttgatt gtaggctcgt tctcgtctgt ccagctcatg taaaatcgtc
     7021 tccttttcgt aatcctttcc tagtttgttg gatcgtactt ttttcttttt gtggatcaat
     7081 tcgtaagtaa aatttttccc acgattcaag caatgaatgc cgaatgtttt aagagaatca
     7141 caaaattggt tatacgttcg agtttttttg tttttcattg tttgatcaat cgcaaaccga
     7201 atttcgtctt tccaaacagg ttcatttttt tcttttaatt tgatttcaga catggttcgt
     7261 ttttcgggtt tcttccctcg ttcagtgatt gttaagtcat gttcaagaca aatctcgtca
     7321 tttaggtcat aacatttgtt taaaaatgct tgaccatggg cttgaaattt gttcccagtt
     7381 tccagattga cggagttaat gacaatgtgg ttatgaatat ggtctttgtc tgtatgtgtg
     7441 taaatcgcga tttggtggtc aggggctatt tttttcgcat actctgcccc tagttgattg
     7501 gctttttcag cggtaatttc tcctggtcga aaagactgga tcaataagtg tgcttgtaca
     7561 cgatcgtctt ttccatacag catgcgaatt tgtttcattt cgcttttggc ataatcaatg
     7621 tcacagttta tccctgtttt gacggttgct cgtggttcgg cgtaattgat cgctcggcta
     7681 caagaagtgg ttcggcttac tttaactgtt gccatatctt ttgtagctcc ttttgcatga
     7741 tttttaggtt ttcggataag cgttgggcgt cgccaggatc aacgtcgtgt tggtgtgtgt
     7801 tgcaccactt ggcaatttga ttgatattcc cgccagcttt ggctaaatcg cgcgcgattg
     7861 cctgagcaat gtctggcgcc actttcggtg tcaccagacg cgcgttttgt gccttggctt
     7921 tcacgaaagc cggcacactc atttgcaaag cttcagctga ctgcttcagc tttgcaaatt
     7981 cggattcgct cactcgaaaa ctgatttgtt ttggctcgga tcgataggta tattttttag
     8041 aatgattgct agccaaatat tgattttgtt cgctcataag tcccaccctt tcagtacgtc
     8101 ctacggacgt atcgttcgca ataccattgt acctaaaaag gtacaataag taaagctcac
     8161 taaagcttac taaagggctt ggcaagctct atatttgcta gccaaatacc tacgtatttg
     8221 gtgcaaataa ccgcttgtca aaggggcgca agctccccct tgaatccccc tcccccccca
     8281 ctctccacaa tacaaaaaag actagcaaat gctagccact ttttgtaaag tttcgcttgt
     8341 ttcaccttcg gtgaaattgt tgcaaatcaa taattaggta gagctacatt tttttcgttg
     8401 ttcaaagatt cttatgccat ttactattaa taaatctata aatatgataa tttttcggct
     8461 ctataattta tgggactgat gaatcagaat tgattcttca gtcccatttt cattttattc
     8521 caaagaatta actccaaata ccaatagaag cccatcctct atatacttga gattccttac
     8581 taacaatttc ttgtaattct attaaagatt taggtaatcc aaatttatgt tttaaaatat
     8641 atcttccaag aaaactactt aatttcatac taacttcacc aacacttttt ccctcactga
     8701 tttctttaga ataaagaaag agcttttctt ttaagtcagg atagtcatct atagttgctt
     8761 cattgtatac tttactaatt gcatttaaaa gtttttcttc tttagtaaaa tccattataa
     8821 taacctccct accactacct tctaggtgcc catggaccat gattaaccca accattaaca
     8881 ataatttttc caatttctcc tttagcttga ttccaatcta cccaacattt ttctttgtta
     8941 caataaagac catttccata gtaagtagct gcatcaactt ttattcctgt accgatgcca
     9001 gctagacaag ttcctaatat tcctagaata acacaatgtt ttaatacttt ctttttcatg
     9061 attgtttttc cttttcgttt ttttaaaatt gcttgttata ttaaataatc ttagtaattt
     9121 tattatataa cattttatta tataacaatg attaacgtca taaaaagtag ttttgaattc
     9181 ataatcgttt aaataaaatt ataagatcag ttatttaaac agctagtaga cataatgtat
     9241 atactaccaa gtaacgcctg taccaaggga tccaggcgct gattttgtga atttttattg
     9301 gtctaggtta aaagctcttt ttaaggcttg gttttctgcg gttgtttctt tctaattctt
     9361 tgtgaatatt gatcggtcat tttttaaata cttgttattt ttgtttgtgt ttgttatgct
     9421 ttttacatat ctcatattca tttattattc ttttctaagg ttaataatag gataatctct
     9481 ttcagaaaga ctgctcgtac gagcagtctt ttcttattta tcaagttttt ctacaaatac
     9541 ttcctcattt tgactgttgt agtaattagg attgagtttt agttcccctt ttttatttcc
     9601 tttgttggcc actgataata acattgggct aaagcttaat attcctagta ggatagaacc
     9661 gaatagcaag tgtttttttg tcataagtat ttccttcttc atttccatag ctgccaccat
     9721 tttttccaat tctttgtttg ttcgtccatt gtttctgttg cttcagaaag agtcgttgaa
     9781 ctattctctg aagactcttc cgtataagtc aactgcagtt gctcctgaag tttttcgatt
     9841 tgttggttgg cttgcagggt gagttgttgt tgctggtcga gtagtttttg tatatgagaa
     9901 ttattttgct ctttgagggc aagttgttct cgtaaaaatt cattttcttc acgcaactga
     9961 tctagcaact tgtttgcaac cacgtttttg tttggtatat aagcattttt atcgttgttt
    10021 tgttcatgtt tatgcaactt atctagcaac ctttgattgt ctaagttgcg agcaagttgc
    10081 aatactccag aacgcaatac aaccttataa ccacgctcat ttttagctat catggaagaa
    10141 tctaattttt ggatatgttt cgatattgct tgcctactca tcttaaaaag atctgacaat
    10201 tcctttattg taaaggtttc ttgtggttgc atactggttg cctcctaggt tgctactgga
    10261 ataaattatc taaatcagat aataaacttt ttttctcttt ttccgaaagt gcggactctg
    10321 tttgtttttc aagagctttt ttctcttttt ctagttgttt gatttgttgg aggagttcaa
    10381 gttctcgttt cttctgtttg attttttcgt taattgttgt agcgggttct tcgtattctt
    10441 tttgtttatc agctaaagcc aatgctttat tttggtcttc tttggttggt gcatgtttgt
    10501 taaagtcgtc tgcttttttg atctcaggtt tgaacgtaaa ttgatagcca ataacaggtt
    10561 ttccccgtcc ttttccgtat ttctttttga ttgttagtcc tttgaagatt gcagttagtt
    10621 cttgacgtat aggttttata actcgtttat ctatatcagg ttgcttataa cttttaggaa
    10681 tatctaataa ttcaagaaag ggttctgttg caaagtttta aataaagaat aaaatccctt
    10741 acggtatcta tgatttaagc tgggattccc aataatacct tgatttcagt acagaccgaa
    10801 aacccgaaga gagtgccttc ttttcgggtt ttcttatata atcctcgaat ggcttccatg
    10861 cctttaatcg tggtagaggc agtgcgtaaa cttcgataga atttattgcg tctctttact
    10921 ggacgatggt cttgttcaat caaattattc aggtatttaa tggtacgatg ttctgtccct
    10981 tgataaaagc cgtattcttt tagtttctta aaggcacttg taatagaggg ggctttatct
    11041 gtgactacaa ccttcggttc atcaaactgc ttcactaacc gcttaagaaa agcataggct
    11101 gcttgtgtgt cccgtttttt acgtaaccaa atatccaagg ttaaaccatc tgcatcgatg
    11161 gctcgataca aataatgcca ttttccttta attttgatgt acgtttcatc cattttccat
    11221 gaataaaagg attttttatt tttctttttc caaatttgat agagtagttt gccatattct
    11281 tgcacccaac gataaatcgt cgtatgagaa acgttaatgc cacgatcata taagatttct
    11341 tgaacttcac gatagctaag gttataacga agatagtagc ccacggctac aataatcaca
    11401 tcctgctgaa attgctttcc tttaaaatga ttcatcgtca ttcctcctgc tatctttttc
    11461 tattattcta ccttatttga tagtagattt aaaactttgc aacagaaccg ccattctgta
    11521 ttccgctaat gggcaatatt tttaaagaag aaaaggaaac tataaaatat taacagcctc
    11581 ctagcgatgc cgaaaagccc tttgataaaa aaagaatcat catcttaaga aattcttagt
    11641 catttattat gtaaatgctt ataaattcgg ccctataatc tgataaatta ttaagggcaa
    11701 acttatgtga aagggtgata actatgagcg ataaaatact tattgtggat gatgaacatg
    11761 aaattgccga tttggttgaa ttatacttaa aaaacgagaa ttatacggtt ttcaaatact
    11821 ataccgccaa agaagcattg gaatgtatag acaagtctga gattgacctt gccatattgg
    11881 acatcatgct tcccggcaca agcggcctta ctatctgtca aaaaataagg gacaagcaca
    11941 cctatccgat tatcatgctg accgggaaag atacagaggt agataaaatt acagggttaa
    12001 caatcggcgc ggatgattat ataacgaagc cctttcgccc actggagtta attgctcggg
    12061 taaaggccca gttgcgccga tacaaaaaat tcagtggagt aaaggagcag aacgaaaatg
    12121 ttatcgtcca ctccggcctt gtcattaatg ttaacaccca tgagtgttat ctgaacgaga
    12181 agcagttatc ccttactccc accgagtttt caatactgcg aatcctctgt gaaaacaagg
    12241 ggaatgtggt tagctccgag ctgctatttc atgagatatg gggcgacgaa tatttcagca
    12301 agagcaacaa caccatcacc gtgcatatcc ggcatttgcg cgaaaaaatg aacgacacca
    12361 ttgataatcc gaaatatata aaaacggtat ggggggttgg ttataaaatt gaaaaataaa
    12421 aaaaacgact attccaaact agaacgaaaa ctttacatgt atatcgttgc aattgttgtg
    12481 gtagcaattg tattcgtgtt gtatattcgt tcaatgatcc gagggaaact tggggattgg
    12541 atcttaagta ttttggaaaa caaatatgac ttaaatcacc tggacgcgat gaaattatat
    12601 caatattcca tacggaacaa tatagatatc tttatttatg tggcgattgt cattagtatt
    12661 cttattctat gtcgcgtcat gctttcaaaa ttcgcaaaat actttgacga gataaatacc
    12721 ggcattgatg tacttattca gaacgaagat aaacaaattg agctttctgc ggaaatggat
    12781 gttatggaac aaaagctcaa cacattaaaa cggactctgg aaaagcgaga gcaggatgca
    12841 aagctggccg aacaaagaaa aaatgacgtt gttatgtact tggcgcacga tattaaaacg
    12901 ccccttacat ccattatcgg ttatttgagc ctgcttgacg aggctccaga catgccggta
    12961 gatcaaaagg caaagtatgt gcatatcacg ttggacaaag cgtatcgact cgaacagcta
    13021 atcgacgagt tttttgagat tacacggtat aacctacaaa cgataacgct aacaaaaacg
    13081 cacatagacc tatactatat gctggtgcag atgaccgatg aattttatcc tcagctttcc
    13141 gcacatggaa aacaggcggt tattcacgcc cccgaggatc tgaccgtgtc cggcgaccct
    13201 gataaactcg cgagagtctt taacaacatt ttgaaaaacg ccgctgcata cagtgaggat
    13261 aacagcatca ttgacattac cgcgggcctc tccggggatg tggtgtcaat cgaattcaag
    13321 aacactggaa gcatcccaaa agataagcta gctgccatat ttgaaaagtt ctataggctg
    13381 gacaatgctc gttcttccga tacgggtggc gcgggacttg gattggcgat tgcaaaagaa
    13441 attattgttc agcatggagg gcagatttac gcggaaagca atgataacta tacgacgttt
    13501 agggtagagc ttccagcgat gccagacttg gttgataaaa ggaggtccta agagatgtat
    13561 ataatttttt aggaaaatct caaggttatc tttacttttt cttaggaaat taacaattta
    13621 atattaagaa acggctcgtt cttacacggt agacttaata ccgtaagaac gagccgtttt
    13681 cgttcttcag agaaagattt gacaagatta ccattggcat ccccgtttta tttggtgcct
    13741 ttcacagaaa gggttggtct taattatgaa taacatcggc attactgttt atggatgtga
    13801 gcaggatgag gcagatgcat tccatgctct ttcgcctcgc tttggcgtta tggcaacgat
    13861 aattaacgcc aacgtgtcgg aatccaacgc caaatccgcg cctttcaatc aatgtatcag
    13921 tgtgggacat aaatcagaga tttccgcctc tattcttctt gcgctgaaga gagccggtgt
    13981 gaaatatatt tctacccgaa gcatcggctg caatcatata gatacaactg ctgctaagag
    14041 aatgggcatc actgtcgaca atgtggcgta ctcgccggat agcgttgccg attatactat
    14101 gatgctaatt cttatggcag tacgcaacgt aaaatcgatt gtgcgctctg tggaaaaaca
    14161 tgatttcagg ttggacagcg accgtggcaa ggtactcagc gacatgacag ttggtgtggt
    14221 gggaacgggc cagataggca aagcggttat tgagcggctg cgaggatttg gatgtaaagt
    14281 gttggcttat agtcgcagcc gaagtataga ggtaaactat gtaccgtttg atgagttgct
    14341 gcaaaatagc gatatcgtta cgcttcatgt gccgctcaat acggatacgc actatattat
    14401 cagccacgaa caaatacaga gaatgaagca aggagcattt cttatcaata ctgggcgcgg
    14461 tccacttgta gatacctatg agttggttaa agcattagaa aacgggaaac tgggcggtgc
    14521 cgcattggat gtattggaag gagaggaaga gtttttctac tctgattgca cccaaaaacc
    14581 aattgataat caatttttac ttaaacttca aagaatgcct aacgtgataa tcacaccgca
    14641 tacggcctat tataccgagc aagcgttgcg tgataccgtt gaaaaaacca ttaaaaactg
    14701 tttggatttt gaaaggagac aggagcatga atagaataaa agttgcaata ctgtttgggg
    14761 gttgctcaga ggagcatgac gtatcggtaa aatctgcaat agagatagcc gctaacatta
    14821 ataaagaaaa atacgagccg ttatacattg gaattacgaa atctggtgta tggaaaatgt
    14881 gcgaaaaacc ttgcgcggaa tgggaaaacg acaattgcta ttcagctgta ctctcgccgg
    14941 ataaaaaaat gcacggatta cttgttaaaa agaaccatga atatgaaatc aaccatgttg
    15001 atgtagcatt ttcagctttg catggcaagt caggtgaaga tggatccata caaggtctgt
    15061 ttgaattgtc cggtatccct tttgtaggct gcgatattca aagctcagca atttgtatgg
    15121 acaaatcgtt gacatacatc gttgcgaaaa atgctgggat agctactccc gccttttggg
    15181 ttattaataa agatgatagg ccggtggcag ctacgtttac ctatcctgtt tttgttaagc
    15241 cggcgcgttc aggctcatcc ttcggtgtga aaaaagtcaa tagcgcggac gaattggact
    15301 acgcaattga atcggcaaga caatatgaca gcaaaatctt aattgagcag gctgtttcgg
    15361 gctgtgaggt cggttgtgcg gtattgggaa acagtgccgc gttagttgtt ggcgaggtgg
    15421 accaaatcag gctgcagtac ggaatctttc gtattcatca ggaagtcgag ccggaaaaag
    15481 gctctgaaaa cgcatttata accgttcccg cagacctttc agcagaggag cgaggacgga
    15541 tacaggaaac ggcaaaaaaa atatataaag cgctcggctg tagaggtcta gcccgtgtgg
    15601 atatgttttt acaagataac ggccgcattg tactgaacga agtcaatact ctgcccggtt
    15661 tcacgtcata cagtcgttat ccccgtatga tggccgctgc aggtattgca cttcccgaac
    15721 tgattgaccg cttgatcgta ttagcgttaa aggggtgata agcatggaaa taggatttac
    15781 ttttttagat gaaatagtac acggtgttcg ttgggacgct aaatatgcca cttgggataa
    15841 tttcaccgga aaaccggttg acggttatga agtaaatcgc attgtaggga catacgagtt
    15901 ggctgaatcg cttttgaagg caaaagaact ggctgctacc caagggtacg gattgcttct
    15961 atgggacggt taccgtccta agcgtgctgt aaactgtttt atgcaatggg ctgcacagcc
    16021 ggaaaataac ctgacaaagg aaagttatta tcccaatatt gaccgaactg agatgatttc
    16081 aaaaggatac gtggcttcaa aatcaagcca tagccgcggc agtgccattg atcttacgct
    16141 ttatcgatta gacacgggtg agcttgtacc aatggggagc cgatttgatt ttatggatga
    16201 acgctctcat catgcggcaa atggaatatc atgcaatgaa gcgcaaaatc gcagacgttt
    16261 gcgctccatc atggaaaaca gtgggtttga agcatatagc ctcgaatggt ggcactatgt
    16321 attaagagac gaaccatacc ccaatagcta ttttgatttc cccgttaaat aaacttttaa
    16381 ccgttgcacg gacaaactat ataagctaac tctttcggca ggaaacccga cgtatgtaac
    16441 tggttcttag ggaatttata tatagtagat agtattgaag atgtaaggca gagcgatatt
    16501 gcggtcatta tctgcgtgcg ctgcggcaag atagcctgat aataagactg atcgcataga
    16561 ggggtggtat ttcacaccgc ccattgtcaa caggcagttc agcctcgtta aattcagcat
    16621 gggtatcact tatgaaaatt catctacatt ggtgataata gtaaatccag tagggcgaaa
    16681 taattgactg taatttacgg ggcaaaacgg cacaatctca aacgagattg tgccgtttaa
    16741 ggggaagatt ctagaaatat ttcatacttc caactatata gttaaggagg agactgaaaa
    16801 tgaagaagtt gtttttttat tgttattgtt attcttaata tacttaggtt atgactacgt
    16861 taatgaagca ctgttttctc aggaaaaagt cgaatttcaa aattatgatc aaaatcccaa
    16921 agaacattta gaaaatagtg ggacttctga aaatacccaa gagaaaacaa ttacagaaga
    16981 acaggtttat caaggaaatc tgctattaat caatagtaaa tatcctgttc gccaagaaag
    17041 tgtgaagtca gatatcgtga atttatctaa acatgacgaa ttaataaatg gatacgggtt
    17101 gcttgatagt aatatttata tgtcaaaaga aatagcacaa aaattttcag agatggtcaa
    17161 tgatgctgta aagggtggcg ttagtcattt tattattaat agtggctatc gagactttga
    17221 tgagcaaagt gtgctttacc aagaaatggg ggctgagtat gccttaccag caggttatag
    17281 tgagcataat tcaggtttat cactagatgt aggatcaagc ttgacgaaaa tggaacgagc
    17341 ccctgaagga aagtggatag aagaaaatgc ttggaaatac gggttcattt tacgttatcc
    17401 agaggacaaa acagagttaa caggaattca atatgaacca tggcatattc gctatgttgg
    17461 tttaccacat agtgcgatta tgaaagaaaa gaatttcgtt ctcgaggaat atatggatta
    17521 cctaaaagaa gaaaaaacca tttctgttag tgtaaatggg gaaaaatatg agatctttta
    17581 ttatcctgtt actaaaaata ccaccattca tgtgccgact aatcttcgtt atgagatatc
    17641 aggaaacaat atagacggtg taattgtgac agtgtttccc ggatcaacac atactaattc
    17701 aaggaggtaa ggatggcgga atgaaaccaa cgaaattaat gaacagcatt attgtactag
    17761 cacttttggg gtaacgttag ctttttaatt taaaacccac gttaactagg acattgctat
    17821 actaatgata caacttaaac aaaagaatta gaggaaatta tattgggaaa aatattatct
    17881 agaggattgc tagctttata tttagtgaca ctaatctggt tagtgttatt caaattacaa
    17941 tacaatattt tatcagtatt taattatcat caaagaagtc ttaacttgac tccatttact
    18001 gctactggga atttcagaga gatgatagat aatgttataa tctttattcc atttggcttg
    18061 cttttgaatg tcaattttaa agaaatcgga tttttaccta agtttgcttt tgtactggtt
    18121 ttaagtctta cttttgaaat aattcaattt atcttcgcta ttggagcgac agacataaca
    18181 gatgtaatta caaatactgt tggaggcttt cttggactga aattatatgg tttaagcaat
    18241 aagcatatga atcaaaaaaa attagacaga gttattattt ttgtaggtat acttttgctc
    18301 gtattattgc tcgtttaccg tacccattta agaataaatt acgtgtaaga tgtctaaatc
    18361 aagcaatctg atctttcata cacataaaga tattgaatga attggattag atggaaaacg
    18421 ggatgtgggg aaacggttct gttgcaaagt tttaaatcta ctatcaaata aggtagaata
    18481 atagaaaaag atagcaggag gaatgacgat gaatcatttt aaaggaaagc aatttcagca
    18541 ggatgtgatt attgtagccg tgggctacta tcttcgttat aaccttagct atcgtgaagt
    18601 tcaagaaatc ttatatgatc gtggcattaa cgtttctcat acgacgattt atcgttgggt
    18661 gcaagaatat ggcaaactac tctatcaaat ttggaaaaag aaaaataaaa aatcctttta
    18721 ttcatggaaa atggatgaaa cgtacatcaa aattaaagga aaatggcatt atttgtatcg
    18781 agccatcgat gcagatggtt taaccttgga tatttggtta cgtaaaaaac gggacacaca
    18841 agcagcctat gcttttctta agcggttagt gaagcagttt gatgaaccga aggttgtagt
    18901 cacagataaa gccccctcta ttacaagtgc ctttaagaaa ctaaaagaat acggctttta
    18961 tcaagggaca gaacatcgta ccattaaata cctgaataat ttgattgaac aagaccatcg
    19021 tccagtaaag agacgcaata aattctatcg aagtttacgc actgcctcta ccacgattaa
    19081 aggcatggaa gccattcgag gattatataa gaaaacccga aaagaaggca ctctcttcgg
    19141 gttttcggtc tgtactgaaa tcaaggtatt attgggaatc ccagcttaaa tcatagatac
    19201 cgtaagggat tttattcttt atttaaaact ttgcaacaga accaaaaata aagtagtaaa
    19261 ttaatcataa tcttttcaac aacaggaata gtcaagttag actgttcctg ttgtttcttt
    19321 attttcctta tcatcttcaa ctttttcaaa tactgcaaat acaaaatatc aatataactt
    19381 attcgttcta tcaatcagtt cctaatatct actcatcaaa atgaaatttc aaactaatct
    19441 catcatagta ttcttttcgt cgattgtaaa attaagctag acaactaaaa agatcatttg
    19501 tgctacactc aaaatagttc cgaccaaaga attattaagg agtgagtaca aatgacctac
    19561 acccatctta caacagacga actggtaatc atagagtctt atttcaaaaa taatcaatcc
    19621 gttgccaaaa ctgcgcaatg cttaggacgt gcgtgacaaa cgattcataa cgtgtatcaa
    19681 tttttgaaaa ctggtgctac gatactgaac tactatcaac aatacaaaga aaacaaaaaa
    19741 cgctgcggta gacgctcgat tgctttacca gaggaacaaa aagaatatgt tcaaaagagg
    19801 gttgttcaag ggtggacacc ggatgtgatt gtcggccgct cggaaatgaa acttgattgt
    19861 tcagtccgta cactgtatcg aatgtttcaa actggcgcat ttaatgtgcg tgatttgcct
    19921 atgaaaggca aacgaaaacc aaatggacac caagaaaaac gtgggaaaca agcttttcgg
    19981 cgcagtatac atgagcgcat caaggagcat ccagaatttg aaaacgagtt tggccatctt
    20041 gaaggagaca ctattgtcgg tcgaaaacac aaaagtgctg ttattacatt ggtggaacgt
    20101 ttgtcaaaag tgattattac attgaagcca gccggtagac aggcaatgga cattgaaaat
    20161 cgaattaatc attggtttca aacggttcct aaacatctgt ttaaatcaat tacgtttgac
    20221 tgtgggaaag aattttcaaa ttggaaagct atgggaaatc aaaatgatat tgatatttat
    20281 tttgcggatc caggcacccc gtcacaacgc gctctaaatg aacattcaaa tggattatta
    20341 cgtcgtgatg gattagttaa agccatggac ttcaatgaag tatcagaatc atttatagag
    20401 tacagaaaac attttctgta ctctattttg tcttctttta aattttcaat agattatatc
    20461 tattgtgaat tttgtagagg gtcagaaact taatagtttt tgacacatgg ttaaattcgc
    20521 gatacaatag gatttgtagt gtttcataaa cttatgtcaa aaagttaagg ggattttcca
    20581 tgattttaga aaataaattg ggtttaacga atcaggttga gttggccaag gctgaagaaa
    20641 aactcagtaa gcaaaaagca aaagaattat atgattctgg aaaaataaat gaaatcgaag
    20701 tcggcacgtt taaaggcttg tctgaaattc atgattttct cttttcagaa atttatgatt
    20761 ttgcaggaaa aattcggaca gttaatattg caaaaggaaa ttttcgtttt gcgccggtca
    20821 tgtacctaga acaatcttta aatcatattg atcagatgcc gcaaacttct ttcgaagaga
    20881 ttattaagaa atacgtggaa atgaatatcg ctcacccttt tcgcgaagga aacgggcgca
    20941 gtactagaat ttggctggat ctcattttaa aggaagaatt gcaaaaagtg gtcgattgga
    21001 acttgatcga taaagcagac tatctttctg caatggagcg cagtccaata aatgacttgg
    21061 aaatacgcta tctcatttcc aatgccctga ctgataaaat tgacgatcgt gagttatata
    21121 tgaaaggaat cgatgtcagc tacttctatg aaggatactc tgagtatacg atagatgatt
    21181 tgtaaaagca ggtgagttaa atgacaaaat atggctatgc acgtgtctca accgcttctc
    21241 aaagtacaaa ggaacagata caacagctac ttgagaacgg tgttgagaag aagaatattt
    21301 tttctgaaaa atttacaggt acgaaacgag atcggccaaa gtttaatcag ctgttggctg
    21361 gtctgaagcc tggagacgaa atcgttgtta cgaaacttga tcgattcgcc cgtaatacaa
    21421 gagaagcact agagatcatt gaacctttac tcgatgataa cgtcacgatt aaggtattga
    21481 atctagggac gatcgaaaat acatcgatgg gtcgaatggt tacacgtacg ttgttgagtg
    21541 tagctgaaat ggaccgtgat atgattgtag aacgtactca ggaagggaaa ttatttgcga
    21601 aaaagaataa tcctaatttt aaagagggac gtccgaaagc aacaatcaca ccaaagaaga
    21661 ggcatgcata tgaattgatt acttccggca aatcgtataa agaagtggaa gccataacgg
    21721 gtttcagtcg tagtacactt tttagaatta agaaacaaat agaagcgagt gagtagaaga
    21781 ttgataaaat taatataaaa atctctttta aatcaaataa atcgttgttt atacgagcat
    21841 tctaaggtca ggttcactca ttaagatgta tcattggtcg aacgaagcgt cataccagct
    21901 acgaatagac atatttttag ggaggaacga agtaaatgaa agaacaacaa ttaggctaca
    21961 ctctttgggg acgtccatta tacggattag aacgaagaac ggctgtatcg attgactgtg
    22021 cttgtggtga gttgattcaa ctcaatattc aaacgaaaca atacaattgt aaaaattgtg
    22081 ggaattgtta ccaattcatt gatcaagact tccaattgct aaacgaaaaa aacaaatagg
    22141 tttattatag tcagacaatt gtctggctat ttttctattt agagaagatc ctcgttgcaa
    22201 acacgaacgt atgtttgtat aatatgagag aagaggggga gaactttatg cttgattact
    22261 caaaagagcc agtcaatgac tactttctaa tcgatatgaa aagtttttac gcaagtgtcg
    22321 aatgtataga aagaaattta gatccattaa cgactgaatt agttgtcatg agtcgagcgg
    22381 ataatacagg atcagggttg attttagctt cttcaccagc tgcaaagaag aaatatggta
    22441 tttctaatgt cagcagacca cgggatctac cacagccttt ccctaaaaca ttacatgttg
    22501 ttccaccacg tatgaacctt tatattaagc gtaatatgca ggtaaataat attttcagaa
    22561 gatatgtggc tgatgaagat ctactgattt actcgatcga tgaatcaatc ttaaaagtga
    22621 cccgatcact gaatcttttt acgactgaag gaacacgaag tcagcgaagg aagaatctcg
    22681 ctcaaatgat ccaagaacgt attaaagaag agctaggatt gattgctacg gtaggcgtcg
    22741 gcgataatcc ccttttggct aaattagcct tagacaatga agcaaagcat aatgaaggat
    22801 ttattgcgga atggacgtac gaaaacgttc ctgagaaagt atggaatatt cccgaaatga
    22861 cggacttttg gggaattggt tcgcgaatga aaaaaaggct caaccaaatg ggaattttga
    22921 gcattagaga ccttgctaac tggaatcctt atacgattaa gaatagatta ggtgtgattg
    22981 gattacagct gtacttccat gctaacggaa tcgatcgaac agatatagca atcccgccag
    23041 aaccgacaaa ggaaaaatct tatggtaatt cacaagtgtt accacgagat tatactagaa
    23101 gaaatgaaat cgagctggtg gtaaaagaaa tggcggaaca agtagccatt cgtatcaggc
    23161 agcataattg caaaacagga tgtgtccatt taaacattgg tacgtcgatc ttagaaacga
    23221 gaccaggatt ttcacaccag atgaaaatcc ctatcacaga taatacaaag gaattgcaga
    23281 attattgtct tttcttgttt gataagtatt atgaaggaca agaagtaagg cacgttggaa
    23341 taacctatag caagctagtt tatactgatt cgcttcagct ggacttgttt agtaatccac
    23401 aaaaacagat tgatgacgaa aaactagaca aaataataga taaaattagg cagaagtatg
    23461 gttttacgtc aattgtacat gcttcttcga tgttagaagg cgctcgtagt attactagaa
    23521 gcacgttggt tggtggccat gcaggcggcg caggggagct taaaaatgat tgactataac
    23581 gatcgaggac gattgaaatg ggtaggattc tatttgtccg atcacacgga agagatcgat
    23641 gcggacaatg agcaacgtgc aaataataat ttggcaaaag aacaaatgac gactgaagag
    23701 atttcggaag tattgaacgc tgcagtcata aaaaatagat cagtatgtat tcaaaaagaa
    23761 gaacgaaacg ctgaaggata ttatccagac gatattgttg gaaagatctt aggtagtgat
    23821 gagctgggga tctacgttgg caaatacaaa attcactacg acgaaatacg tcatatcgaa
    23881 ttttaccagg ataataaatg gagtcgatta gaatgaacat tatccagcaa tatgagctaa
    23941 agtatataac ctttgatcag ctatcagaag agatttgggg ttatggccaa cgtttgataa
    24001 atgaggttgg tgttgagcgc ttctctttct atgtagaagt tgcagcaggt tatcataatt
    24061 ttaggtttta tattttcccg ttatttatat aaggtatttt acggattcta tagagttatc
    24121 tctatgaatc cttttttgtt tttacaaata ggagtagata ctagaataat gcgtgtgtta
    24181 aactattatt gcaatcgcaa taataaaaga aagaaggctt acgcaccatg tctatcaata
    24241 catttgttta ctcgcacccg atcaatgttt acattatcaa gaatttagga atcactgtag
    24301 aacaattttg tgagttatat gcatacccac aaggaacagt tgcaagctgg ataacccgac
    24361 aacgtagaat aaaatcatta cctgcttcat ttgtatatga tctaagtctt gcttctagta
    24421 tgaatatgac cgatgtatac gaaaagttat taatactaga aaatgaatat gatcaattca
    24481 cttcaaatca gcagcgaaaa gtaaagaaac agatagacta gaatagctat tttcgaaaag
    24541 caatatctaa ggtataagtt ataccttaaa taattaaagt ataagttata ccatatatat
    24601 ttagggtata acttatactt ttattcttaa aaaccgctat atccaaacgt ttttagatat
    24661 tattatttaa gttatacttt taatgttgac catttccgat atataagtta tactttaatt
    24721 atcaattaaa gattgggagg atttacatgg atacttttca agggactaca tttacagttg
    24781 gcaattttaa aggaggagta ggtaaaacta agatagtcag catgcttgct tatgacaatg
    24841 caatgataag aaatagaaaa acgcttatta ttgatttaga ccctcaagcg aacttaacac
    24901 aagtcatagc aagaactttc ggtataaccg atatcaaaac cactataaca aatggtgtcg
    24961 caaatggaga attagcaagt agtattatta aggtaaatga aaatcttgac cttctggcat
    25021 gtgacactag ttttcgatca ttctccgctt ttgctaataa acatgaaaat gaattagacc
    25081 aagttactgt cttgaaaaaa ttacttcttc caataaagaa caattatcaa gaaatattta
    25141 ttgatgtacc accaaccatt agcgaatttt ccgataatgc tatggcagct tcagactatt
    25201 cgataatttc atttcaaaca gctgaagaat ccttagaggg agtcaacaaa tatgtaaatt
    25261 atcaaaaatt catggtcgat agatacgatc ttgatttgca aattatagat attgtacctt
    25321 gtatggtaga accaaatgat gattttgatg aagaaatcct agaagaagca attgaaaaat
    25381 acggaaccgt ggtatccaaa aatctcattc attatcaaaa aagattgaga aggtattcta
    25441 aaattggtat acatttaaga aaatacaaaa atggaaattt tgatcaatgg gattataaag
    25501 cacaccaagt atttataaat attttggcag aactagatgc tagacaagag tttttaaata
    25561 aataataagg agttgcataa gtaatgccta aagattttga tattcctaaa atgatggaga
    25621 atggcgaatt tgagccatta ttacccaata acaaacgcca agatgtgaaa ataagcggtg
    25681 aatataactt tagcaatagt gcattgagta acacaaaaaa tattacattg aaaaaaagag
    25741 gccgaccagt ttcaattcct gataaaagaa acaaggtatc agttcctaaa aagatctctc
    25801 cggcattaaa tagcaaactc tcaattttac aagactatat gacggagtta caaagtgaaa
    25861 aagggagaat ttctttcgaa aaaattgtta atacattagc agactcatat atccagcata
    25921 gactaggagt agcaaaagaa gaacacataa gagaagaaat acaagaagag tttgaaaaat
    25981 taccaaaata attttttttc atgcggtatt caattaaagt ataagttata ctagataaat
    26041 gaatattaaa gtataagtta tacattaaat atttaaagta taacttaata aacaacgtgt
    26101 aaatttgcga ttaaatcaac attataaaat tattatttaa agtataagtt atacattatt
    26161 tgtatttaaa gtataactta tacttatttt tttaatatat aacttatacc ttaaatactg
    26221 aaagtgtttt attcaccctt aatacatggt atagttcact tgttgaaaat cgtgaatata
    26281 tacaagtttc tatgaagaag gagaaattta
//
