LOCUS       CP063589               28557 bp    DNA     circular BCT 04-APR-2022
DEFINITION  Enterococcus faecium strain BMT-2-1-1 plasmid pSS-1-1_03, complete
            sequence.
ACCESSION   CP063589
VERSION     CP063589.1
DBLINK      BioProject: PRJNA669626
            BioSample: SAMN16483159
KEYWORDS    .
SOURCE      Enterococcus faecium
  ORGANISM  Enterococcus faecium
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 28557)
  AUTHORS   Both,A., Kruse,F., Mirwald,N., Franke,G., Christner,M., Huang,J.,
            Hansen,J.L., Kroger,N., Berneking,L., Lellek,H., Aepfelbacher,M. and
            Rohde,H.
  TITLE     Population dynamics in colonizing vancomycin-resistant Enterococcus
            faecium isolated from immunosuppressed patients
  JOURNAL   J Glob Antimicrob Resist 28, 267-273 (2022)
   PUBMED   35134550
REFERENCE   2  (bases 1 to 28557)
  AUTHORS   Both,A., Kruse,F., Christner,M., Huang,J., Mirwald,N., Franke,G. and
            Rohde,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-OCT-2020) Institute of Medical Microbiology, Virology
            and Hygiene, University Medical Center Hamburg-Eppendorf,
            Martinistr. 52, Hamburg, Hamburg 20246, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Trycycler v. v0.3.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 705.1x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 10/27/2020 16:53:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.13
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 3,270
            CDSs (total)                      :: 3,179
            Genes (coding)                    :: 3,051
            CDSs (with protein)               :: 3,051
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 128
            CDSs (without protein)            :: 128
            Pseudo Genes (ambiguous residues) :: 0 of 128
            Pseudo Genes (frameshifted)       :: 59 of 128
            Pseudo Genes (incomplete)         :: 65 of 128
            Pseudo Genes (internal stop)      :: 16 of 128
            Pseudo Genes (multiple problems)  :: 11 of 128
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..28557
                     /organism="Enterococcus faecium"
                     /mol_type="genomic DNA"
                     /strain="BMT-2-1-1"
                     /isolation_source="rectal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1352"
                     /plasmid="pSS-1-1_03"
                     /geo_loc_name="Germany: Hamburg"
                     /lat_lon="53.33 N 10.1 E"
                     /collection_date="2014-07-08"
                     /collected_by="Institute of Medical Microbiology, Virology
                     and Hygiene, University Medical Center Hamburg-Eppendorf"
     gene            join(28321..28557,1..1326)
                     /locus_tag="IQN11_15925"
     CDS             join(28321..28557,1..1326)
                     /locus_tag="IQN11_15925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="UOC39522.1"
                     /translation="MTEKNIMVIPARKRVGSTAAKEKIKKLRVAAYCRVSTETEEQNSS
                     YEVQVSHYTEFIKKNNEWEFAGIFADDGISGTNTKKRDEFNRMIAECMDGNIDMVITKS
                     ISRFARNTLDCLQYIRQLKDKNISVYFEKENINTTDAKGEVLLTIMASLAQQESQSLSQ
                     NVKLGLQYRYQQGKVQVNHKRFMGYTKDEDGNLTIVPEEAEIIKRIYREYLEGQSLVGI
                     GRALEKDGILTAAGKPRWRPESVKKILQNEKYIGDALLQKTVTVDFLTKKRVKNEGHVP
                     QYYVENSHEAIIPKELFLQAQEEIHRRSNIYTGEGKNKRIYSSKYALSAITFCGDCGDI
                     YRRVYWNIHGRKEFVWRCVTRIEQGPEVCKNRTVKEDELYGAVMTAINKLLAGGNNMIK
                     TLEENIHAVIGETTEYQISEINNSLEEKQKELIKLANKGQDYDHLADEIDELRDKRQIL
                     LVEDASLSGENERINELIEFIRKNKFRTLEYDDKLVRKIIQSVTVYEGHFVIAFKSGIE
                     MEI"
                     /name="recombinase family protein"
     gene            1469..1693
                     /locus_tag="IQN11_15930"
     CDS             1469..1693
                     /locus_tag="IQN11_15930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018579902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="UOC39523.1"
                     /translation="MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDE
                     LKAIADVLGVKFVQAFILPDGEEIKISNE"
                     /name="helix-turn-helix transcriptional regulator"
     gene            1708..2577
                     /locus_tag="IQN11_15935"
     CDS             1708..2577
                     /locus_tag="IQN11_15935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002328890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase domain-containing protein"
                     /protein_id="UOC39524.1"
                     /translation="MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYY
                     NSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDWINGGGWLFINGYHVDLILRDIKRV
                     EQIMKDTEHGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAETYPNA
                     LQKSLVNFFMFEAGFSLMFVKANSGTDDKYYIAGHVFRIVSCLNQVLFACNNAYCINEK
                     KAIKLLETFEHKPEKYTEKVNHIFEVLGISLFECYDMTEKLYNEVNEIVSEINNFLNEE
                     SSDERKQI"
                     /name="nucleotidyltransferase domain-containing protein"
     gene            2558..3292
                     /locus_tag="IQN11_15940"
     CDS             2558..3292
                     /locus_tag="IQN11_15940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016250180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="UOC39525.1"
                     /translation="MKENKYDDNIFFQKYSQMSRSQKGLAGAGEWETLKKMLPDFKGKR
                     VLDLGCGYGWHCIYAMENGASSVVGVDISHKMLEVAKGKTHFPQIEYECCAIEDVDFPE
                     ESFDVILSSLAFHYVADYENLIKKIYRMLKAGGNLVFTVEHPVFTAHGTQDWYYNEKGE
                     ILHFPVDNYYYEGKRTAMFLEEKVTKYHRTLTTYLNTLLSNSFIINQIVEPQPPENMMD
                     IPGMADEMRRPMMLIVSAKKKM"
                     /name="class I SAM-dependent methyltransferase"
     gene            3325..4233
                     /locus_tag="IQN11_15945"
     CDS             3325..4233
                     /locus_tag="IQN11_15945"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032491779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside nucleotidyltransferase ANT(6)-Ia"
                     /protein_id="UOC39526.1"
                     /translation="MRSEKEMMDLVLSLAEQDERIRIVTLEGSRANINIPKDEFQDYDI
                     TYFVSDIEPFISNDDWLNQFGNIIMMQKPEDMELFPPEEKGFSYLMLFDDYNKIDLTLL
                     PLEELDNYLKGDKLIKVLIDKDCRIKRDIVPTDIDYHVRKPSAREYDDCCNEFWNVTPY
                     VIKGLCRKEILFAIDHFNQIVRHELLRMISWKVGIETGFKLSVGKNYKFIERYISEDLW
                     EKLLSTYRMDSYENIWEALFLCHQLFRAVSGEVAERLHYAYPEYDRNITKYTRDMYKKY
                     TGKTGCLDSTYAADIEERREQ"
                     /name="aminoglycoside nucleotidyltransferase ANT(6)-Ia"
     gene            4230..4772
                     /gene="sat4"
                     /locus_tag="IQN11_15950"
     ARG             4231..4769
                     /name="sat4"
                     /gene="sat4"
                     /gene_name="streptothricin N-acetyltransferase Sat4"
                     /tool="amrfinderplus"
                     /drug_class="STREPTOTHRICIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            4865..5659
                     /gene="aph(3')-IIIa"
                     /locus_tag="IQN11_15955"
     ARG             4866..5656
                     /name="aph(3')-IIIa"
                     /gene="aph(3')-IIIa"
                     /gene_name="aminoglycoside O-phosphotransferase
                     APH(3')-IIIa"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            5935..6507
                     /locus_tag="IQN11_15960"
     CDS             5935..6507
                     /locus_tag="IQN11_15960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001079940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HTH domain-containing protein"
                     /protein_id="UOC39529.1"
                     /translation="MNRINRVTSILIQLQSKKIIPAKEIAQRFNISLRTVYRDIRTLEE
                     AGIPIGSEAGKGYFLVEGFLLPPVMFTAAEVGALITAGKFLNCHGDESFIKDFDSAMYK
                     IKSILKHGEKNYAQELENSINVYSTSGQKNTLADNVIAAIQTAICNKRVISIQYPASGG
                     QEPESRMIEPISLGFYEQNWYLIGFAG"
                     /name="HTH domain-containing protein"
     gene            6805..7701
                     /locus_tag="IQN11_15965"
     CDS             6805..7701
                     /locus_tag="IQN11_15965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002355409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family protein"
                     /protein_id="UOC39530.1"
                     /translation="MIQYYYTKKEWGVVMEKEKLKILEELRRILNNKNEAIIILNNYFK
                     GGVGKSKLSTMFAYLTDKLNLKVLMIDKDLQATLTKDLAKTFEVELPRVNFYEGLKNGN
                     LASSIIHLTDNLDLIPGTFDLMLLPKLTRSWTFENESRLLATLLAPLKSDYDLIIIDTV
                     PTPSVYTNNAIVASDYVMIPLQAEEESTNNIQNYISYLIDLQEQFNPGLDMIGFVPYLV
                     DTDSATIKSNLEELYKEHKEDNLVFRNIIKRSNKVSTWSKNGITEHKGYDKKVLSMYEN
                     VFFEMIERIIQLENEKE"
                     /name="ParA family protein"
     gene            7800..8009
                     /locus_tag="IQN11_15970"
     CDS             7800..8009
                     /locus_tag="IQN11_15970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000527318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-binding protein"
                     /protein_id="UOC39531.1"
                     /translation="MGNLGAQKAKRNDTPISAKKDIMGDKTVRVRADLHHIIKIETAKN
                     GGNVKEVMDQALEEYIRKYLPDKL"
                     /name="peptide-binding protein"
     gene            8026..8298
                     /locus_tag="IQN11_15975"
     CDS             8026..8298
                     /locus_tag="IQN11_15975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002333002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antitoxin"
                     /protein_id="UOC39532.1"
                     /translation="MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVN
                     LLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYSKQILNKEKVA"
                     /name="antitoxin"
     gene            8300..9163
                     /locus_tag="IQN11_15980"
     CDS             8300..9163
                     /locus_tag="IQN11_15980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010782381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zeta toxin family protein"
                     /protein_id="UOC39533.1"
                     /translation="MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSG
                     KTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELVKLYEKDVVKHVTPYSNRMTEALIS
                     RLSDQGYNLVIEGTGRTTDVPIQTATMLQSKGYETKIYVMAVPKIESYLGTIERYETMY
                     ADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISP
                     KETLERELNRKVSGKEIQPTLERIEQKMVQNQHQETPEFKAIQQKMESLQLPTPPIPKT
                     PKLPGI"
                     /name="zeta toxin family protein"
     gene            complement(9426..10163)
                     /gene="erm(B)"
                     /locus_tag="IQN11_15985"
     ARG             complement(9430..10163)
                     /name="erm(B)"
                     /gene="erm(B)"
                     /gene_name="23S rRNA (adenine(2058)-N(6))-methyltransferase
                     Erm(B)"
                     /tool="amrfinderplus"
                     /drug_class="LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(10288..10371)
                     /locus_tag="IQN11_15990"
     CDS             complement(10288..10371)
                     /locus_tag="IQN11_15990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001814874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA methyltransferase attenuation leader
                     peptide"
                     /protein_id="UOC39539.1"
                     /translation="MLVFQMRNVDKTSTVLKQTKNSDYADK"
                     /name="23S rRNA methyltransferase attenuation leader
                     peptide"
     gene            10518..11198
                     /locus_tag="IQN11_15995"
     CDS             10518..11198
                     /locus_tag="IQN11_15995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="UOC39535.1"
                     /translation="MNPFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            11202..11819
                     /locus_tag="IQN11_16000"
     CDS             11202..11819
                     /locus_tag="IQN11_16000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016175297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="UOC39540.1"
                     /translation="MDTVRDFILYLKLCNRTYYFKSEKDTSSLTLTLEEGVEPDKVTSK
                     VINQLKEKGSLKHLGEYEVLDTAMLTKGIGQILSTITYFITAVAGISLFIAGVGVMNMM
                     YISVSERTKEIGIRRALGATRKSIMLQFLLEGLILTLSGGLIGYLLGMALAYSVGSLIK
                     VNVSLDLFTILLAVGVSSVIGLVFSVMPASEAAKKDLIDILR"
                     /name="FtsX-like permease family protein"
     gene            12220..12825
                     /locus_tag="IQN11_16005"
     CDS             12220..12825
                     /locus_tag="IQN11_16005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016176895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell filamentation protein"
                     /protein_id="UOC39536.1"
                     /translation="MILENKLGLTNQVELAKVEEKLSKQKAKELYDCGKINEIEVGTFK
                     GLSEIHEFLFSDIYDFAGKIRSVNIAKGNFRFAPVMYLEHSLQHIDQMPQTSFEEIIKK
                     YVEMNIAHPFREGNGRSTRIWLDLILKEELQKVVDWNLIDKADYLSAMERSPINDLEIR
                     YLISNALTDKIDDRELYMKGIDVSYFYEGYSEYTIDDL"
                     /name="cell filamentation protein"
     gene            12841..13413
                     /locus_tag="IQN11_16010"
     CDS             12841..13413
                     /locus_tag="IQN11_16010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000170424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="UOC39537.1"
                     /translation="MTKYGYARVSTASQSTKEQIQQLLENGVEKKNIFSEKFTGTKRDR
                     PKFNQLLAGLKPGDEIVVTKLDRFARNTREALEIIEPLLDDNVTIKVLNLGTIENTSMG
                     RMVTRTLLSVAEMERDMIVERTQEGKMFARKNNPNFREGRPKATITPKKRHAYELLTSG
                     KSYKEVEAITGFSRSTLFRIKKKIEES"
                     /name="recombinase family protein"
     gene            complement(13665..13922)
                     /locus_tag="IQN11_16015"
     CDS             complement(13665..13922)
                     /locus_tag="IQN11_16015"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC39542.1"
                     /translation="MANLYIENKGDLNAIITLIVVMVKSIGNITIGMLFIILAAVLIFM
                     IVIWFLNERSKDNQHRRDMEIKSIESIDYLSIITLKKPRS"
                     /name="hypothetical protein"
     gene            complement(14048..14863)
                     /locus_tag="IQN11_16020"
     CDS             complement(14048..14863)
                     /locus_tag="IQN11_16020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002326780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC39538.1"
                     /translation="MVKIAGLSKGGKTVSQLYKQNYRDWRQFRKNIKDSYFILPTELEK
                     YLPNNKAINLYLYYCFKAKNEGGDSWHSVNTIAESLGVTTKTINTWNKTLVDLGMIARI
                     DDNHLSKSTILLPLSSYYKLALDSSLKDVTESTVHEIDGNLVAVYHLFEWRKNEADENY
                     NVPYNTLCCVFKRKTQKDTIYKFILVQDEKISNFELSTPSSKIYDDAYRFECQDLEALL
                     SANNLNNIEHENFVVNTRFNLVSEKDSDLLDLLIELTKNLDKKENITVL"
                     /name="hypothetical protein"
     gene            15380..16705
                     /locus_tag="IQN11_16025"
     CDS             15380..16705
                     /locus_tag="IQN11_16025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002335330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Y-family DNA polymerase"
                     /protein_id="UOC39509.1"
                     /translation="MMDYSKEPVNDYFLIDMKSFYASVECIERNLDPLTTELVVMSRAD
                     NTGSGLILASSPAAKKKYGISNVSRPRDLPQPFPKTLHVVPPRMNLYIKRNMQVNNIFR
                     RYVADEDLLIYSIDESILKVTRSMNLFTTEGTRSQRRKKLAQMIQENIKEELGLLATVG
                     VGDNPLLAKLALDNEAKHNDGFLAEWTYQNVPDKVWNIPEMTDLWGIGSRMKKRLNQIG
                     IMSIKDLANWNPYTIKSHLGVIGLQLYFHANGIDRTDIAIPPEPTKEKSYGNSQVLPRD
                     YTRRNEIELVVKEMAEQVAIRIRQHNCKTGCVHLYIGTSILETRPGFSHQMKIPITDNT
                     KELQNYCLFLFDKYYEGQEVRHVGITYSKLVYTDSLQLDLFSDPQKQIDEENLDKIIDK
                     IRQKYGFTSIVHASSMLEGARSITRSTLVGGHAGGAGGLKND"
                     /name="Y-family DNA polymerase"
     gene            16698..17048
                     /locus_tag="IQN11_16030"
     CDS             16698..17048
                     /locus_tag="IQN11_16030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002359653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC39510.1"
                     /translation="MIDYNDRGRLKWAGFYLSDHTEKIDADNEQRANQNLAKEQMTTEE
                     VAEVLNAAVIKNRSVCIQKEERNAEGYYPEDIVSKILGSDELGIYVGKNKVHYDEIRHI
                     EFYQDNKWGRLE"
                     /name="hypothetical protein"
     gene            17045..17215
                     /locus_tag="IQN11_16035"
     CDS             17045..17215
                     /locus_tag="IQN11_16035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001021554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC39511.1"
                     /translation="MNIIQQYELKYITFDQLSEEIWGYGQRLINEVGVERFSFYVEAAA
                     GYHKYEYYIGY"
                     /name="hypothetical protein"
     gene            complement(18119..18394)
                     /locus_tag="IQN11_16040"
     CDS             complement(18119..18394)
                     /locus_tag="IQN11_16040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001196543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type III secretion system protein PrgO"
                     /protein_id="UOC39512.1"
                     /translation="MALLPTNKDKKKIGAEDISIKDDINVELGERKYTAKERKPVQVDP
                     PVLKTIRDLSYAKDIPMYEIVKLAMDAYVDTLNDEERIIYNRRSKD"
                     /name="type III secretion system protein PrgO"
     gene            complement(18366..19319)
                     /locus_tag="IQN11_16045"
     CDS             complement(18366..19319)
                     /locus_tag="IQN11_16045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016623100.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family protein"
                     /protein_id="UOC39513.1"
                     /translation="MENLRTAFKTSDKLGKVVMLTGRKGGIGKTTDNDLLAIVSSQLFE
                     KDVLLIDYDQQRNTTSNIGSTYQITSFDRSMSAAIKKGDWVSGITQVSPHLYIMAGSPG
                     SEELNEYLSEKYPDRRKRSLAFIKPLEELRKNFDYIFIDCPPSTDNVVRAFLTAADYII
                     AMQELKRYAMEGTEDFINKVLVPIVTNFEESHLQIIGILPVLFSVRRSSQHANYQKTID
                     KYGESNIFKSIVKGSDRLEMYGENGIQLNDYVDRRWWAIFADIFTELEERIEYYEQHGD
                     IEGFDYTPKYADSMANHILPLGKEIKLNGIITNEQR"
                     /name="ParA family protein"
     gene            19931..21424
                     /locus_tag="IQN11_16050"
     CDS             19931..21424
                     /locus_tag="IQN11_16050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000947690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primase C-terminal domain-containing protein"
                     /protein_id="UOC39514.1"
                     /translation="MLSEIYSAILKNGLRTYKYRNSTMKPAGHIDSSRSGAIFAYRSKQ
                     LMNVGRGMVITSEEAILENEKKLTHWTPNTYRFGTYADDYRTVVKGHSEKNLSQINTFV
                     VDIDSKENHQGEIILACLDQVGYMPTLILESDHGYQVYFVLKTPGYVTKKSNFKVIDVA
                     KKISKTIRLQLAEKLSGVDLGCNHFGIARFPQENNIVFKEMNYQYSFADWIQWSMKLES
                     DQKTKEDRERKLIVFPEKKEIRQVDEPWFDMLLHKANIVGGEGRLGRNNVIFTLSLAYY
                     SSGYALDTCEYNMFTFNERLQEPLSEAELVKIVRSAYSGNYQAASREFIIELCQQWVSP
                     TLKNNDLFIQRRGWWKFKKPRDQRKYSHKNEWKEDLLAYLSEKSLASEPYLNLSKKELA
                     SQLTMPKRTLDKILNELREENKVFYKVTRGRNGGMIIASVKTLFARVIQLSKEKRLDYS
                     TRITEVFGLNESLVEETFRQLSTPLNPLKEVNLFEVDTG"
                     /name="primase C-terminal domain-containing protein"
     gene            21559..21855
                     /locus_tag="IQN11_16055"
     CDS             21559..21855
                     /locus_tag="IQN11_16055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000053907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type III secretion system protein PrgN"
                     /protein_id="UOC39515.1"
                     /translation="MSLKNYVYSHPVNVFIIGRLGLSVEVFCELYGFKQGTLSSWVTRE
                     KTVASLPIEFLHGLSLASGETMDQVYDCLCVLEQEYIEYKIANELRKRKKYIQ"
                     /name="type III secretion system protein PrgN"
     gene            21956..22807
                     /locus_tag="IQN11_16060"
     CDS             21956..22807
                     /locus_tag="IQN11_16060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002354342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC39516.1"
                     /translation="MKSDDWIEHTWLPLKRNSKRKKFWVLQLWPLGKLCSYGARLILDL
                     TVYSIGVFGTAYYLINDPNRIAASDIFTVLMTLIFVMLLSIFTQLVMQFTRQKLTAGKL
                     FKSLFDLIVVNAILATLIKQIEQSGRTTKGVKDFLLTFIHFVNGHMYLFEVGIILFFVG
                     YVSTKLIKRSIEKEIEIDLIPTLLGYEYNVDFGRYDELINTDIVHTSIHESTVKGIRSI
                     LKNGQEMKAIDRRKEIYNFYEVEASLRYGIGKLWLDGSNIRQNKPYIFWNSSDLELPMK
                     DK"
                     /name="hypothetical protein"
     gene            22828..23111
                     /locus_tag="IQN11_16065"
                     /pseudo=""
     CDS             22828..23111
                     /locus_tag="IQN11_16065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002345737.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            23473..24153
                     /locus_tag="IQN11_16070"
     CDS             23473..24153
                     /locus_tag="IQN11_16070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="UOC39517.1"
                     /translation="MNPFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            24334..25293
                     /locus_tag="IQN11_16075"
     CDS             24334..25293
                     /locus_tag="IQN11_16075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000221326.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
                     /protein_id="UOC39518.1"
                     /translation="MTYKHLTIDELTMIESYYLQHNKPVEIANRMGRAIQTIYNVVNKF
                     KQGKTALDYWHQYKENKKKCGRKVIQLPAHEVDYIKEKVTLGWTPDVIIGRKERSVSCG
                     MRTLYRLFSKGIFDIDTLPMRGKRKPNGHQEKRGKQQYQRSIHDRSDNYPDFNSEFGHL
                     EGDTIVGIHHKSAVITLVERLSKVIITIKPNGRKALDIETALNQWFSRFPKNFFKSITF
                     DCGKEFSNWKAISNQHDIDIYFADPGTPSQRPLNENSNGILRRNGLPKSMDFRKVNQTF
                     ISSVSNQRNHIPRKSLNYRTPIEIFLSYVQEAFYSSLI"
                     /name="IS30 family transposase"
     gene            25615..25785
                     /locus_tag="IQN11_16080"
     CDS             25615..25785
                     /locus_tag="IQN11_16080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000713595.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC39519.1"
                     /translation="MKKFIYRVLENDEVVAIFNEQQYAQDFIAYEKTISDKQFEIEKVD
                     IADWLLQPREF"
                     /name="hypothetical protein"
     gene            25799..26401
                     /locus_tag="IQN11_16085"
     CDS             25799..26401
                     /locus_tag="IQN11_16085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002333458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="UOC39520.1"
                     /translation="MAKIGYARVSSKEQNLDRQLKALEGVSKVFSDKLSGQSVERPQLQ
                     AMLNYIREGDIVVVTELDRLGRNNKELTELMNQIQIKGATLEVLNLPSMNGIEDENLRR
                     LINNLVIELYKYQAESERKRIKERQAQGIEIAKKKGKFKGRQPKFKENDPRLQHAFDLF
                     LNGCSDKEVEEQTGINRRTFRRYRSRYNVTVDQRKKQ"
                     /name="recombinase family protein"
     gene            26417..27094
                     /locus_tag="IQN11_16090"
                     /pseudo=""
     CDS             26417..27094
                     /locus_tag="IQN11_16090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000108743.1"
                     /note="incomplete; partial on complete genome; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase"
                     /name="DNA topoisomerase"
     gene            27606..27902
                     /locus_tag="IQN11_16095"
     CDS             27606..27902
                     /locus_tag="IQN11_16095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002360685.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA recombinase"
                     /protein_id="UOC39541.1"
                     /translation="MSKGFLEPALFNQERNVLDSEIKNLTTEKTNLVTNSASGVLRANE
                     IKDLINYVSADNFNGDYTEELFEEFVVNIIVNSRDELTFNLKCGLSLKEKVVR"
                     /name="DNA recombinase"
     gene            27903..28319
                     /locus_tag="IQN11_16100"
     CDS             27903..28319
                     /locus_tag="IQN11_16100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000323438.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase"
                     /protein_id="UOC39521.1"
                     /translation="MAYIPYGYKIQDGVVTVDEKAAGQVKVFFEKYISGLSLTVAGEQA
                     GIEKTHSVMGRILKNVNYLGNDTYPAIIDKEIFDKAEEVRDKRAKDLGRVVELAAFTSP
                     PPKERFKMKKADNKMPVDPFERAEYLYSLIESEE"
                     /name="recombinase"
     ARG             3326..4230
                     /name="ant(6)-Ia"
                     /gene="ant(6)-Ia"
                     /gene_name="aminoglycoside nucleotidyltransferase
                     ANT(6)-Ia"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(9427..10163)
                     /name="ErmB"
                     /gene="ErmB"
                     /gene_name="Erm 23S ribosomal RNA methyltransferase"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; lincosamide antibiotic;
                     streptogramin antibiotic; streptogramin A antibiotic;
                     streptogramin B antibiotic"
                     /identity="98.37"
                     /coverage="98.79"
     ARG             4231..4772
                     /name="SAT-4"
                     /gene="SAT-4"
                     /gene_name="streptothricin acetyltransferase (SAT)"
                     /tool="rgi"
                     /drug_class="nucleoside antibiotic"
                     /identity="99.44"
                     /coverage="100.0"
     ARG             3326..4233
                     /name="aad(6)"
                     /gene="aad(6)"
                     /gene_name="ANT(6)"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="100.0"
                     /coverage="109.42"
     Typing          19932..21424
                     /name="rep_cluster_185"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.866"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 aaaaagcgtg acgaatttaa tcgcatgatt gcagagtgta tggacggtaa catcgacatg
       61 gttattacaa aatccatcag ccgatttgcg cgtaacaccc tagactgcct tcaatacatt
      121 agacagctca aggataagaa catatcagtt tattttgaga aagagaacat caacaccacg
      181 gatgccaaag gtgaggtttt gctgactatt atggcatctt tggcacagca ggaaagccag
      241 agcctttcac aaaacgttaa gcttgggcta cagtaccgat accaacaagg aaaggtgcag
      301 gtcaaccata agcgatttat gggctacacg aaagatgaag atggaaattt aactattgtc
      361 cccgaagaag ctgagattat caaacgcatc taccgagaat accttgaggg tcagagtcta
      421 gtgggcattg gtcgagccct tgaaaaggat ggtattttaa cagcagcggg aaaaccaaga
      481 tggcgaccag aatcagttaa gaagatactt caaaacgaaa aatacatcgg agatgccctt
      541 ctgcaaaaga ctgtcacagt agattttctg accaagaaac gagtgaaaaa tgaagggcat
      601 gttccccaat attatgttga aaatagccat gaagcgatta ttcctaaaga gttatttttg
      661 caggcgcaag aagaaattca tcggagaagc aatatctaca caggagaagg caagaacaaa
      721 agaatttaca gtagcaagta cgctttaagt gccatcacct tctgtggaga ttgtggcgat
      781 atttatagac gggtctattg gaatatccac ggaagaaaag aatttgtctg gcgatgcgtg
      841 actagaatcg agcaaggtcc tgaagtttgt aagaaccgaa ccgtaaaaga agatgaactt
      901 tatggtgcag taatgactgc gattaataag ctacttgcag gtgggaacaa tatgataaag
      961 acactggaag agaatattca tgctgtgatt ggcgaaacca cagaatacca aatttcagag
     1021 attaacaact cactagagga aaaacaaaaa gaactaatca agctggcgaa caagggtcaa
     1081 gactatgacc acttagcaga tgagattgat gagctgagag acaagcgaca gatcctttta
     1141 gtagaagatg cctccctcag tggcgagaac gagcgaatca atgagctgat tgaatttatc
     1201 cgcaagaaca aattccgcac cttagaatat gatgataagc ttgtaaggaa gataatccag
     1261 agcgttacag tctatgaagg ccacttcgtc atagccttca aatctggcat cgaaatggaa
     1321 atatgaaaac cagaagtaaa tagcccatga ctctacagta gagttgtggg ttttcttttg
     1381 cttgctgatt ataataatat tttaataact attgtgttta tcaaccaaat ggtttataat
     1441 attcttagcg taaacttgga ggtgctgtat gactacggca gaaatgatta aagaactgtg
     1501 tgagcaaatg aatataagtg tttccgaact tgctagacgt attggccaga ctccacagaa
     1561 tttcaataaa aaattacaac gagaaacagt aaccttggat gagttgaagg ccattgctga
     1621 tgtgctaggt gtcaagtttg tgcaggcatt tattttacca gatggagaag aaataaaaat
     1681 atctaacgaa taaaggagga tgtttatatg gtaggtaatg ttattcaaat agtaacagag
     1741 aaattatcat ctttgccttt tatagaaggc atcgtattag ggggctcacg tgcaagaggc
     1801 acccatacag aaaattctga tatagatatc ggaatctatt acaattcaga ctcatttgac
     1861 ctgacagcga ttaatcaaat tgctacagaa ttggatgata aaaatagaaa caaccttgtt
     1921 gtgcctcccg gagcgtgggg tgattggatt aatggcggcg gatggttatt tataaatggg
     1981 tatcatgtgg atttaatttt acgtgatatt aaacgtgtgg aacaaataat gaaagataca
     2041 gagcacggaa ttgttactgc caattatcag actgggcatc cccatggtta tattagtgca
     2101 atgtatcgag gagaattagc gattagcaaa atactatatg ctaagaatga aagcttatgc
     2161 gaattaaaaa aacaggcaga aacttatccc aatgctttgc agaaaagttt agttaacttt
     2221 tttatgtttg aagcagggtt ctctttaatg tttgtaaaag caaattcggg aacagacgat
     2281 aaatattata ttgcgggtca tgtttttcgt atagtttcat gtttaaatca agtgttattt
     2341 gcatgtaata atgcttattg tatcaacgaa aagaaagcta taaaactgct tgaaactttt
     2401 gaacataaac ctgaaaaata taccgagaag gtaaatcata tttttgaagt actcggtatc
     2461 tcactttttg aatgctacga catgaccgag aagctttata atgaagtgaa tgaaattgta
     2521 tcggagataa ataacttttt aaacgaggag agttcagatg aaagaaaaca aatatgatga
     2581 taatatattt tttcaaaaat acagtcaaat gagtcgctcg cagaaaggac tggctggtgc
     2641 gggagaatgg gagactttga aaaagatgct acctgatttt aagggtaagc gtgtgcttga
     2701 tttaggatgc ggctatggat ggcactgtat atatgcgatg gaaaacggtg cttcctctgt
     2761 agtaggtgtt gatatttctc ataaaatgct cgaagtagca aaaggaaaaa cccattttcc
     2821 acagattgaa tatgaatgct gtgccataga agatgtggat ttcccagagg agagctttga
     2881 tgtaatacta agttcgcttg cgtttcatta tgtagcagac tatgagaatt taataaaaaa
     2941 gatatatagg atgctgaagg ctggtggcaa tttagttttt acagttgaac atcctgtttt
     3001 tactgctcat ggaacacaag actggtatta taacgaaaaa ggagaaatac tgcatttccc
     3061 ggtggacaat tattattatg agggcaaacg gacagctatg tttttggaag aaaaggttac
     3121 aaaatatcat agaacactga ccacatatct aaatacactg ctttcaaata gttttataat
     3181 aaatcagatt gtggagccac agccgccaga gaacatgatg gatattccgg ggatggcgga
     3241 tgaaatgcga cgcccaatga tgctgattgt atcggcaaaa aagaagatgt aataatatag
     3301 aaaaaataaa cgaggagtat gtaaatgaga tcagaaaaag aaatgatgga tttagtactt
     3361 tctttagcag aacaggatga acgtattcga attgtgaccc ttgaggggtc acgcgcaaat
     3421 attaatatac ctaaagatga atttcaggat tatgatatta catattttgt aagtgatata
     3481 gaaccgttta tatctaatga tgactggctt aatcaatttg ggaatataat aatgatgcaa
     3541 aagccggagg atatggaatt attcccacct gaagaaaagg gattttccta tcttatgcta
     3601 tttgatgatt acaataaaat tgatcttacc ttattgccct tggaagagtt agataattac
     3661 ctaaagggcg ataaattaat aaaggttcta attgataaag attgtagaat taaaagggac
     3721 atagttccga ctgatataga ttatcatgta agaaagccaa gcgcaaggga gtatgatgat
     3781 tgctgcaatg aattttggaa tgtaacacct tatgttatta aaggattgtg ccgtaaggaa
     3841 attttatttg ctattgatca ttttaatcag attgttcgcc atgagctgct gagaatgata
     3901 tcatggaagg tcggcatcga aacaggcttt aaattaagtg taggcaagaa ctataagttt
     3961 attgaaaggt atatatccga ggatttgtgg gagaaacttt tgtccaccta ccggatggat
     4021 tcctatgaaa acatatggga agcattattt ctatgccatc aattgttcag ggcggtatcc
     4081 ggtgaggtgg cggaaaggct tcattatgcc tatccggagt atgataggaa tataacaaaa
     4141 tataccaggg acatgtataa aaaatacact ggtaaaaccg gctgcctgga tagcacatat
     4201 gccgctgata tagaagagag gcgggaacag tgattacaga aatgaaagca gggcacctga
     4261 aagatatcga taaacccagc gaaccatttg aggtgatagg taagattata ccgaggtatg
     4321 aaaacgagaa ttggaccttt acagaattac tctatgaagc gccatattta aaaagctacc
     4381 aagacgaaga ggatgaagag gatgaggagg cagattgcct tgaatatatt gacaatactg
     4441 ataagataat atatctttac taccaagacg ataaatgcgt cggaaaagtt aaactgcgaa
     4501 aaaattggaa ccggtacgct tatatagaag atatcgccgt atgtaaggat ttcagggggc
     4561 aaggcatagg cagcgcgctt atcaatatat ctatagaatg ggcaaagcat aaaaacttgc
     4621 atggactaat gcttgaaacc caggacaata accttatagc ttgtaaattc tatcataatt
     4681 gtggtttcaa aatcggctcc gtcgatacta tgttatacgc caactttgaa aacaactttg
     4741 aaaaagctgt tttctggtat ttaaggtttt agaatgcaag gaacagtgaa ttggagttcg
     4801 tcttgttata attagcttct tggggtatct ttaaatactg tagaaaagag gaaggaaata
     4861 ataaatggct aaaatgagaa tatcaccgga attgaaaaaa ctgatcgaaa aataccgctg
     4921 cgtaaaagat acggaaggaa tgtctcctgc taaggtatat aagctggtgg gagaaaatga
     4981 aaacctatat ttaaaaatga cggacagccg gtataaaggg accacctatg atgtggaacg
     5041 ggaaaaggac atgatgctat ggctggaagg aaagctgcct gttccaaagg tcctgcactt
     5101 tgaacggcat gatggctgga gcaatctgct catgagtgag gccgatggcg tcctttgctc
     5161 ggaagagtat gaagatgaac aaagccctga aaagattatc gagctgtatg cggagtgcat
     5221 caggctcttt cactccatcg acatatcgga ttgtccctat acgaatagct tagacagccg
     5281 cttagccgaa ttggattact tactgaataa cgatctggcc gatgtggatt gcgaaaactg
     5341 ggaagaagac actccattta aagatccgcg cgagctgtat gattttttaa agacggaaaa
     5401 gcccgaagag gaacttgtct tttcccacgg cgacctggga gacagcaaca tctttgtgaa
     5461 agatggcaaa gtaagtggct ttattgatct tgggagaagc ggcagggcgg acaagtggta
     5521 tgacattgcc ttctgcgtcc ggtcgatcag ggaggatatc ggggaagaac agtatgtcga
     5581 gctatttttt gacttactgg ggatcaagcc tgattgggag aaaataaaat attatatttt
     5641 actggatgaa ttgttttagt acctagattt agatgtctaa aaagctttaa ctacaagctt
     5701 tttagacatc taatcttttc tgaagtacat ccgcaactgt ccatactctg atgttttata
     5761 tcttttctaa aagttcgcta gatagagttc tatattagag atgtaaagag ttttggtgaa
     5821 gaggtttgtg agtatggctt ttataaccag ggtgcaatga gaagcactaa cagcagctag
     5881 cttaagaacg cataggatat actttttatg gaagtcacag aggaggaata aaatttgaac
     5941 aggattaaca gagtaacctc tattcttatt cagctgcaat caaaaaaaat aattcctgcc
     6001 aaagaaattg cacagcgatt taatataagc ttaaggacag tttacagaga tatccggaca
     6061 cttgaagaag ccggaatacc aattggatct gaggccggaa aaggatattt tcttgtagag
     6121 ggcttcctac ttccgccggt aatgtttaca gcggcggaag tgggtgcatt gattacagca
     6181 gggaaatttt taaattgcca tggagatgaa tcatttataa aggattttga ttcagctatg
     6241 tataaaatca aatctatttt gaagcatggt gaaaaaaact atgcacagga gttggagaac
     6301 agtattaacg tgtacagcac atctggacag aaaaatacat tggcggataa cgttattgca
     6361 gcaattcaga ctgcaatctg caataaaagg gtaatatcaa ttcaatatcc tgcatcagga
     6421 gggcaagaac cggaaagcag aatgatagag cctatatcac tggggtttta tgaacagaac
     6481 tggtacttaa tcggttttgc aggctaagaa atgaatatag gaattttcgt gtggatcgga
     6541 ttaaaagcat ttgcatagaa gaagagctct gtcaaagcca tgatggctct ttggaacaaa
     6601 tattaaaaca aatgctttca tataaaaaac tatatgccct acaatgccgt tgtaaaaatt
     6661 ggggaaaagg gatatattga ttttatatct ttctcaaaat aaatataaaa gccctttaaa
     6721 gagggctttt atatattaat cacaaatcac ttatcacaaa tcacaagtga ttaatcacaa
     6781 atcacttgtg atttgtgatt cttaatgata caatattact atacaaaaaa agaatggggc
     6841 gtagttatgg agaaggaaaa actaaaaata cttgaagaat taagacgtat tttaaacaat
     6901 aaaaatgaag caattattat cttgaataat tactttaaag gtggtgttgg aaagtccaaa
     6961 ttatcgacta tgtttgctta cttgacagac aaattgaatt taaaagtttt aatgatcgat
     7021 aaggacttac aggcaacatt gacaaaagac ttagcaaaaa cttttgaggt agaattgcca
     7081 cgtgtcaatt tttatgaagg cttgaaaaat ggaaacttgg cttcttctat tattcatttg
     7141 actgataatt tagacttgat ccctggcacg tttgatttga tgttactgcc aaaattaact
     7201 cgctcatgga cgtttgaaaa tgaaagtaga ttgcttgcta ctcttttagc acctttaaaa
     7261 agtgactatg atcttattat tattgatact gtaccaacgc caagcgttta tacaaataat
     7321 gcaatcgtgg cgagtgatta cgttatgatc cctttacaag cagaagaaga aagtacaaac
     7381 aacattcaaa actatatttc ctatttgatt gatttgcaag aacagtttaa ccctggacta
     7441 gatatgattg gttttgttcc ttatttagtt gatacggaca gcgcaacgat aaaatcaaac
     7501 ctggaagaac tgtacaaaga acataaagag gataatttgg ttttccgaaa tattatcaag
     7561 cgaagtaata aagtaagtac ttggtctaaa aatggcatta cagaacacaa aggctatgac
     7621 aaaaaagttt tgtctatgta tgagaacgta ttttttgaaa tgattgagcg aatcattcaa
     7681 ttagaaaatg aaaaagaata gaatcacaaa tcacaagtga ttaatcacaa atcacttgtg
     7741 atttgtgata ggtgatgata aaataaatag taagaagaaa tagaaagaag tgagcgatcg
     7801 tgggaaattt aggcgcacag aaagcaaaac gaaatgatac gccaatcagc gcaaaaaaag
     7861 atataatggg ggataagacg gttcgtgttc gtgccgactt gcaccatatc ataaaaatcg
     7921 aaacagcaaa gaatggcgga aacgtaaaag aagttatgga tcaagcctta gaagaatata
     7981 tacggaaata tttacctgac aaactttaaa aggagtgaaa atgaaatggc agttacgtat
     8041 gaaaaaacat ttgaaattga aatcattaat gagttatcgg caagtgttta taatcgggta
     8101 ttaaattatg ttttgaatca tgaactagat actaaaaata ctcgtttact agaagtgaat
     8161 cttttaaatc aattagaagt ggcacaagaa gttgatttat ttcaacaacc atttgaagaa
     8221 ttacaagcta ttcatgagta ttggcggtca atgaatcaat attcaaaaca aattttgaat
     8281 aaagagaaag tggcttaaca tggcgaatat tactgacttc accgaaaagc aatttgaaga
     8341 tcgtttagaa aagaatgttg aacgactaac taaaaataga ctagcggttg aatcgccaac
     8401 cgctttttta cttggtgggc aaccagggtc agggaaaacc agtttgcgat cagcaatttt
     8461 tgaagaaaca caagggaatg ttattgtcat tgataatgat acctttaaac aacagcaccc
     8521 aaattttgac gaattagtga aactctatga aaaagacgta gtaaaacacg ttacccctta
     8581 ttcgaatcgc atgacagaag cacttattag ccgtttaagc gatcaaggct ataatttagt
     8641 gattgaagga acaggacgaa caacagacgt tcccattcaa acagccacaa tgcttcaatc
     8701 taaaggttat gaaacaaaaa tatacgtcat ggcagtaccg aaaattgaat catacttagg
     8761 aacgattgaa cgatatgaaa ccatgtatgc agatgatcca atgacagcta gggcaacacc
     8821 aaaacaagcg catgatattg ttgtcaaaaa cttaccgacc aatttagaaa cccttcataa
     8881 aacgggctta tttagcgata taaggcttta caatagagaa ggagtgaaac tctattcaag
     8941 cttagaaacg ccttccatta gtccgaaaga gaccttagaa agagaattaa atcgtaaagt
     9001 atcagggaaa gaaattcaac cgactttgga gagaatagag caaaaaatgg ttcaaaatca
     9061 acaccaagaa acccctgaat ttaaagcaat tcaacaaaaa atggaaagct tgcagctacc
     9121 tacaccacca atacccaaaa cacctaaact tccaggtatt taaaccttaa aaaaggaaaa
     9181 gagtagttac caaaaaacgg taactactct ttttttataa aaacatttcc tcatgttggg
     9241 gtcccgagcg cctacgagga atttgtatcg ataagaaata gatttaaaaa tttcgctgtt
     9301 tttttctaat ttcattttga ggtgaattaa ttggtagtta ttagaggtgc cctataccta
     9361 ataatttatc tacattccct ttagtaacgt gtaactttcc aaatttacaa aagcgactca
     9421 tagaattatt tcctcccgtt aaataataga taactattaa aaatagacaa tacttgctca
     9481 taagtaacgg tacttaaatt gtttactttg gcgtgtttca ttgcttgatg aaactgattt
     9541 ttagtaaaca gttgacgata ttctcgattg acccattttg aaacaaagta cgtatatagc
     9601 ttccaatatt tatctggaac atctgtggta tggcgggtaa gttttattaa gacactgttt
     9661 acttttggtt taggatgaaa gcattccgct ggcagcttaa gcaattgctg aatcgagact
     9721 tgagtgtgca agagcaaccc tagtgttcgg tgaatatcca aggtacgctt gtagaatcct
     9781 tcttcaacaa tcagatagat gtcagacgca tggctttcaa aaaccacttt tttaataatt
     9841 tgtgtgctta aatggtaagg aatattccca acaattttat acctctgttt gttagggaat
     9901 tgaaactgta gaatatcttg gtgaattaaa gtgacacgag tgttcagttt taatttttct
     9961 gacgataagt tgaatagatg actgtctaat tcaatagacg ttacctgttt acttatttta
    10021 gccagtttcg tcgttaaatg ccctttacct gttccaattt cgtaaacggt atcggtttct
    10081 tttaaattca attgttttat tatttggttg agtacttttt cactcgttaa aaagttttga
    10141 gaatatttta tatttttgtt catgtaatca ctcctgaagt gattacatct ataaacaaat
    10201 acagaagtta aacgatttgt ttgtaatttt agttatctgt ttaaaaagtc ataagattag
    10261 tcactggtag gaattaatct aacgtattta tttatctgcg taatcactgt ttttagtctg
    10321 tttcaaaacg gtagatgttt tatctacatt acgcatttgg aataccaaca tgacgaatcc
    10381 ctccttctta attacaaatt tttagcatct aatttaactt caattcctat tatacaaaat
    10441 tttggttctg ttgcaaagtt ttaaatctac tatcaaataa ggtagaataa tagaaaaaga
    10501 tagcaggagg aatgacgatg aatcctttta aaggaaagca atttcagcag gatgtgatta
    10561 ttgtagccgt gggctactat cttcgttata accttagcta tcgtgaagtt caagaaatct
    10621 tatatgatcg tggcattaac gtttctcata cgacgattta tcgttgggtg caagaatatg
    10681 gcaaactact ctatcaaatt tggaaaaaga aaaataaaaa atccttttat tcatggaaaa
    10741 tggatgaaac gtacatcaaa attaaaggaa aatggcatta tttgtatcga gccatcgatg
    10801 cagatggttt aaccttggat atttggttac gtaaaaaacg ggacacacaa gcagcctatg
    10861 cttttcttaa gcggttagtg aagcagtttg atgaaccgaa ggttgtagtc acagataaag
    10921 ccccctctat tacaagtgcc tttaagaaac taaaagaata cggcttttat caagggacag
    10981 aacatcgtac cattaaatac ctgaataatt tgattgaaca agaccatcgt ccagtaaaga
    11041 gacgcaataa attctatcga agtttacgca ctgcctctac cacgattaaa ggcatggaag
    11101 ccattcgagg attatataag aaaacccgaa aagaaggcac tctcttcggg ttttcggtct
    11161 gtactgaaat caaggtatta ttgggaatcc cagcttaaat catagatacc gtaagggatt
    11221 ttattcttta tttaaaactt tgcaacagaa cctattattt taagtctgaa aaggatacat
    11281 cgtctctaac gttaacttta gaggaaggag ttgaacctga caaggtgacc tctaaagtga
    11341 taaaccaatt gaaagaaaaa ggtagtttga aacatttggg ggaatatgaa gtgttagata
    11401 cggctatgtt aacgaaagga attggtcaaa tcctcagtac gatcacttat tttataacag
    11461 ctgtagcagg tatatcttta tttatcgcag gggtaggtgt aatgaacatg atgtatatat
    11521 ctgtatctga acgaacaaaa gagatcggta taagaagagc cctaggagct actcgaaaat
    11581 cgattatgct gcagttcctt ttagaaggtt tgattttaac tctttcagga gggttaattg
    11641 gctatttatt aggaatggct cttgcttata gtgttggttc tttgataaag gtaaacgtgt
    11701 cacttgatct atttactatt ttactagcgg ttggggtatc ttcggttatt ggactggtct
    11761 tttctgtaat gcccgcttca gaggctgcaa aaaaagattt aattgatatt cttagataaa
    11821 atcagaatga caagaatatt tacgttctag attctaaaat aaaacacaaa gagaccaacc
    11881 aggcacccta ttgtttcttt gtagtataga gatattcttt ggcttgtaag agatcaatag
    11941 agttaggtga ccggagttcg aaataaagga aatttttgat tgtataggag aattctttat
    12001 ccctaatatt tagaattttg agtatgccat gttgatgttt tagattctct ataaatatag
    12061 aggtgtatca aaggtcaact agactgtgca aaatagagac acttgaaaaa tctatcgggg
    12121 gtcagaaact taatagtttt tgacacataa acaaaatcgc gatataatgg ggttgagagt
    12181 gtttcataaa cttatgtcat aaagttaagg agatttcgca tgattttaga gaataaattg
    12241 ggattaacca atcaagttga gttggctaag gttgaagaaa aactcagtaa acaaaaagcg
    12301 aaagaattgt acgattgtgg aaaaataaat gaaatcgaag ttggtacatt taaaggttta
    12361 tctgaaattc atgaatttct attttcggat atttacgatt ttgccggaaa aatccgatcg
    12421 gtcaatattg caaaaggaaa ttttcgattt gcaccagtta tgtatttaga acattcgtta
    12481 cagcatattg atcagatgcc acaaacttct tttgaagaga ttatcaagaa atatgtggag
    12541 atgaatatcg ctcacccatt tcgagaagga aatggccgaa gtactagaat ttggctggat
    12601 ctcattttaa aggaagaatt gcaaaaagtt gtagattgga acttaatcga taaagcagac
    12661 tatctttctg caatggagcg aagtcccata aacgatttgg aaatacgcta tctaatttcc
    12721 aatgctctga ctgataaaat tgacgatcgc gagttatata tgaaaggaat cgatgtcagc
    12781 tatttctatg aagggtattc tgagtatacg atagatgatt tgtaaaagta ggtggaccaa
    12841 atgacgaaat atggatatgc acgtgtctca accgcttctc aaagtacaaa agaacaaatt
    12901 caacagttgc ttgagaacgg cgtagagaag aagaatattt tttcagaaaa atttacgggt
    12961 acaaaacggg atcggccaaa attcaatcag ctgttggctg gtctgaagcc tggagatgaa
    13021 atagttgtta cgaagcttga tcgatttgct cgtaacacga gagaagcatt agagatcatt
    13081 gaacctttac tcgatgataa cgtaacgatc aaggttttga atctaggaac gattgaaaat
    13141 acgtccatgg ggcgaatggt gacacggacg ttgttgagtg tagcagaaat ggaacgtgat
    13201 atgattgtgg aacgtaccca agaaggaaaa atgtttgcaa gaaagaataa tcctaatttc
    13261 agagaaggac gtccgaaagc aacaatcaca ccgaagaaga ggcacgcata tgaactgctt
    13321 acttcaggta aatcgtataa ggaagttgaa gctataaccg gtttcagtcg cagtacgctt
    13381 tttagaataa agaagaaaat tgaagaaagt taaaaaagaa gtctcagcga accagacagg
    13441 taaatactta atgcgttcta gatatgagtc tattagcatg ttgtgaaata taatattttt
    13501 ttatttactt gatttctgct caaaaaatgt gtatggtaac tgtaaaaggt aaagtaatta
    13561 aaggtatgct agccacgctt actatattag gataccatca tatatttata atgaacgatt
    13621 tgttcgtcta ccaaacaaca catatcgttc agcgtaagtc acgtttagga acgtggcttt
    13681 tttagtgtta ttatcgataa ataatctatt gactctattg attttatctc catatcccta
    13741 cggtgttgat tgtctttaga tctttcattt aagaaccaaa taactatcat aaaaatcagc
    13801 actgctgcta atataataaa cagcattcct attgtgatat tacctattga ttttaccata
    13861 actacgatta aagtaataat ggcattcaag tctcctttgt tctctatata taaattagcc
    13921 ataaatcatc ttcctttcaa attaagatac ttgtttgata ccaataaata gtaagcgtgg
    13981 ctagcatacc tttttctgta atagcaagtg ttctaatagt ccaaacttaa tgatggaccg
    14041 atgctagtta tagtacagta atgttttctt tcttatctag atttttagta agctctatca
    14101 gcaaatctaa caaatctgag tccttttcag aaactaaatt aaatctagtg tttacaacaa
    14161 agttttcatg ttctatattg tttagattat ttgcggaaag gagggcttct agatcttgac
    14221 attcaaatct atatgcatcg tcataaatct tactagaagg agtgcttaat tcgaaattac
    14281 ttattttctc atcttggacc aagataaatt tatagatagt atctttttgt gtttttcttt
    14341 taaaaacaca acagagtgtg ttataaggaa cgttataatt ttcatcagcc tcattttttc
    14401 tccattcaaa caaatgataa actgcaacca agttgccatc aatttcatgg acagtgctct
    14461 cggtaacatc ctttaaagaa ctatcaaggg ctaatttata gtaactagag agaggaagta
    14521 aaattgtcga tttactgaga tggttatcgt ctatacgtgc aatcatacct aaatcaacta
    14581 aggttttatt ccaggtgttt atagttttag ttgtcactcc tagagactct gctatggtat
    14641 tgaccgaatg ccaggaatcc ccgccttcat tctttgcctt aaaacagtaa tacagatata
    14701 aattaatagc tttgttattc ggtaaatatt tttcaagttc tgttggtaga ataaagtaag
    14761 aatccttaat gttttttctg aactgtctcc agtctctgta gttttgttta taaagttgtg
    14821 aaacggtttt tccaccttta gaaagtcctg ctatcttaac caatcttatt gctcctttct
    14881 tgaatctgtc atgatcatac agtatttttt acttgtagtc cagcacctta atatattatc
    14941 ctatgtaatt aatttcgtac tagatagtaa ttatttttta tttaattctc tagtcactta
    15001 caaataagtt atataaacta cgattaataa attattacaa aaactattaa gaaaacttct
    15061 acatacaact attacaaaac tattaagaaa ctgaatactc ctattttttg tttttaagga
    15121 aagttttttc ttttttgaat ttcttatttt tttctaatat aactaagcaa aactggataa
    15181 tacgacactt attttcaaat tttcacaaga ctaatagtaa atatccattt aataaagtga
    15241 tacaatgtgt tgattttaca aatcaacaga agaagtaggg aaataactta cctatgcttc
    15301 tttttttgta catttaatcg attcttcttt acaaaaacga acgtatgttt gtataatgtg
    15361 gaagaatgga gtgttattta tgatggatta ttcaaaagag ccagtaaatg attacttttt
    15421 gatcgatatg aaaagctttt acgcaagtgt cgaatgtata gaaaggaatt tagatccatt
    15481 aacgactgaa ttagtcgtca tgagtcgagc ggataataca ggatcagggt tgattttagc
    15541 ttcttcacca gctgcaaaga agaagtacgg tatttctaat gtcagtcgac cacgagatct
    15601 accgcaacct tttcctaaaa cgttacatgt cgttccacca cgcatgaatc tctatattaa
    15661 gcgaaatatg caggtaaaca atattttcag aaggtatgta gcagacgaag atttattgat
    15721 ttactcgatc gatgaatcga tcttaaaagt gaccagatca atgaatcttt ttacgactga
    15781 aggaacaaga agtcaacgga gaaagaagct ggctcaaatg atccaggaga atattaaaga
    15841 agagctagga ttgcttgcta cagtaggtgt cggagataat cccttattag ctaaacttgc
    15901 tttagacaat gaagcaaaac ataatgatgg attccttgct gaatggacgt atcaaaatgt
    15961 tcctgataaa gtatggaata ttcctgaaat gacagacctt tggggtattg gatctcgaat
    16021 gaaaaaaaga ctcaaccaaa ttggtatcat gagtattaaa gacttagcta attggaatcc
    16081 atacactatt aagagccatt taggtgtgat tggcttacag ctgtattttc atgcgaacgg
    16141 gatcgatcga acagatatag cgatcccgcc agaaccgaca aaggaaaaat catatggtaa
    16201 ttcacaagtg ttaccacgag attataccag gagaaatgaa atcgaactgg tggtaaaaga
    16261 aatggcggaa caagtagcta ttcgtatcag gcaacataac tgtaaaacag gttgtgtcca
    16321 tttatacatt ggcacgtcga tcttagaaac gagaccaggt ttttcacacc agatgaagat
    16381 ccctataaca gataatacaa aggaattgca gaattactgt cttttcttgt ttgataagta
    16441 ttatgaagga caagaagtaa ggcacgttgg aataacctat agcaagcttg tgtacactga
    16501 ttcgcttcag ctggatttat ttagtgatcc acaaaagcaa attgacgaag aaaatttaga
    16561 taaaattatt gacaagattc ggcaaaaata tggttttacg tcgattgtac atgcttcttc
    16621 tatgttagaa ggcgctcgta gtattactag aagtacattg gttggtggcc atgcaggcgg
    16681 cgcaggaggg cttaaaaatg attgattata atgatcgtgg acgtttaaag tgggcaggtt
    16741 tttatttatc tgatcatact gaaaaaattg atgccgacaa tgaacaacga gccaatcaaa
    16801 atttggcaaa agaacaaatg acgactgaag aggttgcgga agtattgaac gctgcagtca
    16861 taaaaaatag atcagtatgt attcaaaaag aagaacgaaa cgctgaagga tactatccag
    16921 aagatattgt tagcaagatc ttaggtagtg atgagctggg gatctacgtt ggaaaaaaca
    16981 aagttcacta cgacgaaata cgtcatatcg aattttacca ggataataaa tggggtcgat
    17041 tagaatgaac attatccagc aatatgagct aaagtatata acctttgatc agctatcaga
    17101 agagatttgg ggttatggcc agcgtttgat aaatgaggtt ggtgttgaac gcttctcttt
    17161 ctatgtagaa gctgcagcag gataccataa atacgaatac tatattggct attaaagtgc
    17221 aataaaatta tatttctttt atgttttaca ttttgtatca attctgataa aattacctat
    17281 aggtaattaa aaaatataaa aaaactagtt acaaccttag gacgttgtaa ctagcttgaa
    17341 gcatactaga gctaactaaa atagcactag aaagcaatgt taaacccgtc caacaaactt
    17401 gatttaacat tgagaccagc ttattcagct aaatatagtt gaataagctt cttttgtttt
    17461 aaaaaaacaa aaggtgtact acgaataacg caagtaaaag aaatactatt acaaccagta
    17521 ggctacaagt aagtattact aaacattgcg tagttagaac ctttgctcta ttgtctaaag
    17581 ccacaaaatt agagatcagc tttatgatgc taagagcgag ctgcatccat gcggacatag
    17641 gttcttttga cactattaat tctccttttt aggataaggg aaattgctag tagttttttc
    17701 attagcacca tcccccttca tttgattgag tctagtgctg ctgtgatagt ttgctgttta
    17761 atatgcttac attcttatta taacataaat gaaacaaaca catggttaga ggtcgtatca
    17821 atcaaaatag tgtctcacaa acgatttatt acttactcct gctgactaac ggactgttct
    17881 tcagtaactg taactatatg tttgttaaaa ccaccattac ctgtagataa aaaccaatat
    17941 atttactata ctcactatat taaatatatt tagtatagta aaaactagaa acaataaaat
    18001 ttgtgaatgt tgtatacccc caaacaatac acatattttg aaggattagg attaataaag
    18061 ctaaaaatat agtaagtata ctaaatatat ttactatatc tagtatactt actatatttt
    18121 aatcttttga tcgtctatta tatataatcc gttcctcgtc gtttaaagta tcaacatagg
    18181 cgtccattgc aagtttgact atttcataca taggaatatc ttttgcataa ctaagatccc
    18241 gaatggtttt tagtacggga ggatctactt gaactggttt tctttctttc gcagtgtact
    18301 ttcgttcccc taactcgaca ttaatatcat ctttaattga aatatcttca gcaccaattt
    18361 tcttcttatc tttgttcgtt ggtaataatg ccatttagtt taatctcctt tccaagaggt
    18421 aggatatgat tggccattga gtcagcatat ttaggtgtat aatcaaatcc ttcaatatca
    18481 ccatgttgtt catagtattc aattctttct tctaattctg taaagatgtc tgcaaaaata
    18541 gcccaccatc ttcgatctac ataatcattt aattggatac cattctcacc atacatttct
    18601 aaccgatccg agcctttaac aatgctttta aaaatgtttg attcaccata cttatcaatt
    18661 gttttttgat agtttgcgtg ttgagaggaa cgtcgcactg agaaaagaac aggcaaaatt
    18721 ccaatgattt gaagatgaga ctcttcaaaa ttcgtgacaa tcggaactaa aactttatta
    18781 ataaaatctt ctgttccttc cattgcgtac cgttttaatt cttgcattgc aataatataa
    18841 tctgcagcag ttaagaatgc acgaaccaca ttatctgttg atggtgggca gtcgataaag
    18901 atataatcga aattttttct caattcttct aaaggtttaa tgaaggccaa tgatctctta
    18961 cgacgatcag gatatttttc ggacaagtat tcattaagtt cttcagatcc aggagagcca
    19021 gccataatat ataaatgtgg acttacttga gtaatacctg aaacccagtc cccttttttg
    19081 attgctgcag acatggatcg atcaaagcta gtaatttgat acgttgatcc aatgttggaa
    19141 gtagtatttc tttgttggtc ataatcaatt agcaacacgt ctttttcaaa aagttgacta
    19201 gaaacaatcg ctaataaatc attgtctgta gtcttaccaa tgccgccttt tctacctgta
    19261 agcattacaa cttttcctag tttatctgat gttttaaatg cagtccgtaa gttttccata
    19321 gttccctcca atttcctata ctaaatatat ttagtatact tcatatactt aatatattcg
    19381 atatatctaa tatactccaa attgataaga attcagactt tataaggaat atagtggata
    19441 tactaaatat atttgctata ttcagtatat cagatatatt caaaatgtca aaatatattt
    19501 gtgcgttttg cgttgacaat ttagagtgaa aagaggtaaa cttaattcta tagaaaccac
    19561 agataattca ctatttacaa agtagcaaaa gcagtggtac tctttaaaca gaaaaattac
    19621 ataaaaaaaa gagacggaaa taattgattt tagcagaatc aattatttct gaatcacatg
    19681 gttaggacat gtgttcacgc tcgtctcaag aatatgtaag tagctaccaa ctacttatat
    19741 taaaagttga tcggatacct tttccgattg cctttattct accaaaaaaa ggcgagcaac
    19801 tcaacagaag aacgtttatt tagtgtactt aaattaaata ttcttaaaca ctgaagagag
    19861 aacacatact atggctgaga ttaaagctaa actgtgttct ctttttgttt gagaaaggac
    19921 gttacaatcg atgttgagcg aaatttattc agctattctt aaaaacggct tacgtacata
    19981 caaatatcga aacagcacca tgaaacctgc aggtcatatt gattccagta ggagtggtgc
    20041 tatctttgcg taccgtagca agcaattaat gaatgttggg cgtggtatgg tcattacttc
    20101 ggaagaagct attttagaga acgaaaagaa actaacgcat tggacaccta atacctatcg
    20161 ctttggtact tatgcggatg attatcgaac agtggttaaa ggtcattctg agaaaaactt
    20221 aagtcaaatc aacacatttg tagttgatat cgattcaaaa gagaaccatc aaggcgaaat
    20281 tattttagcc tgtttagatc aagtgggcta catgccaacg ctaattttag aatcagatca
    20341 tggttatcaa gtttattttg tactaaagac accaggctat gtcacaaaga aaagcaattt
    20401 caaggtgatc gatgtagcaa aaaaaatttc aaaaacaatt cgtctacagt tggctgaaaa
    20461 attgtccgga gtggatctag gatgtaacca cttcggaatt gctcgattcc cacaagaaaa
    20521 taatattgtt tttaaagaaa tgaactatca gtattctttt gctgactgga ttcaatggtc
    20581 gatgaagctt gaatcagatc aaaaaacaaa agaagatcga gaacgaaaac taattgtctt
    20641 tcctgagaaa aaagaaattc gtcaagtaga tgaaccgtgg ttcgatatgt tacttcataa
    20701 agcaaacatc gtcggcggag aaggacgtct tggtcgaaat aatgtgattt tcacgctttc
    20761 tttagcttat tactcttcag gttatgcatt ggatacttgc gaatacaata tgttcacatt
    20821 caacgaacgg ttacaggaac cgctatctga agcagaatta gtaaagattg tacgtagtgc
    20881 ttattctggt aattatcaag cagcaagcag agaattcatt attgaattgt gccagcaatg
    20941 ggtttcacca accttaaaaa ataatgatct gttcattcaa cgacgtggct ggtggaaatt
    21001 taaaaagcca cgagatcaaa gaaaatatag tcataaaaat gaatggaaag aagatctatt
    21061 ggcttatcta agcgaaaaaa gtcttgctag tgagccttat ttgaacctgt caaaaaaaga
    21121 attggcttca caactaacga tgcccaagcg aacacttgat aagatcttaa atgagttacg
    21181 agaggagaat aaagtcttct acaaggtaac acgaggaaga aatggcggaa tgatcattgc
    21241 ttcagtcaaa acgttgttcg cgagggttat tcaactaagt aaagaaaaga gactagatta
    21301 ttcaacaagg atcacagagg tatttggact caacgagagc ttagtagaag agacatttag
    21361 acaattatca acccccttga accctcttaa agaagtgaat ctttttgaag tagatacagg
    21421 ttgaaaaata aaaggtgcaa attgccttat acaatatatc tatgatactt ctgtaggtgt
    21481 tgctcccttt gcctagctac gtgtaggtgg tatacttata actgcgtatg cagtcttatg
    21541 tatcatggag gaagttgtat gtcgttaaaa aattatgtct attcacatcc tgttaatgtg
    21601 tttatcattg gtcgtttggg attatctgtg gaagtgttct gtgagcttta tggttttaag
    21661 caggggactt tgtcttcttg ggttaccagg gaaaaaacag ttgcttcttt gccgattgag
    21721 tttcttcatg ggttgtcctt agcttctggg gagactatgg atcaggtata tgattgtttg
    21781 tgtgtgttag agcaggagta tattgagtat aaaatagcta acgagttaag aaaaaggaag
    21841 aagtatatcc agtagtagtt tttatttact taaaaaattg gttcattgag caacctatcg
    21901 ctgctaaagt agcaaaggaa aacgttaaag gaaagaattt agggaagaaa tcgaaatgaa
    21961 atcggacgac tggattgaac acacctggct tcctctgaaa agaaatagca aacgaaagaa
    22021 attttgggta ttgcaattat ggccattagg aaaactttgt agttacgggg cacgacttat
    22081 tcttgattta accgtttact cgattggagt atttggaacg gcttattact tgataaatga
    22141 tcccaatagg attgcagcat cagacatttt tacagtgcta atgacgttga tttttgtcat
    22201 gctattgtct atttttactc aattagtcat gcaatttacc aggcaaaaat taacagcagg
    22261 aaaacttttc aaaagcctat tcgatttaat tgttgtaaat gcaattctag cgactttaat
    22321 aaaacaaatt gaacaatctg gaagaacaac aaaaggagtg aaggattttt tattgacgtt
    22381 tattcacttt gtaaatggac acatgtattt gtttgaagtg ggtattattc tcttttttgt
    22441 cgggtatgta tccacgaaac ttattaaacg ttcaattgaa aaagaaattg aaattgacct
    22501 gattccgaca cttcttggtt atgagtacaa tgttgatttt ggaagatatg acgaattgat
    22561 caatacggat atcgttcaca cgagtatcca tgaatctact gttaagggca tcagatctat
    22621 tttaaaaaat ggccaggaaa tgaaagcaat agatcgaaga aaagagatct acaattttta
    22681 tgaagtcgaa gcaagcctac gatatggcat cggaaaattg tggttagatg gaagtaatat
    22741 tcgtcaaaac aaaccataca ttttttggaa cagtagtgat ttagaacttc caatgaaaga
    22801 taaataatta tggagaatcg tttgaaaatg attcctctat acaggattgt gcttatagtt
    22861 ggcatggagt taaaaacctt aaagaaggag cagttattca aagtgaaaga acgtcataat
    22921 cagttactat gtagtaaaac gggtacgatg aacattgaat accgaacaga atatttagaa
    22981 ttaacgaatc aaactgattt tttgttgatt cgaaagcaac aagagcaaga aaaaaattaa
    23041 tggctactta tagccaattg attgatgaat gggaacaatt caaggaatct aaaattccag
    23101 aacgtctcta aaagccttta tttgtaaaga gcataaggaa acgtgggaac actttttaaa
    23161 aaaagtgttc caataggctg tgcctattac gtttctcaaa aataaatgtg ggaacaaaat
    23221 atttaaaaat aggatagtga aaggatagtg aaggatagta aaaggagggt agtaggatag
    23281 caaaaaggat aggctccttt tcgctatcct ttttaaattg gaggaattaa tatggaagta
    23341 agaataagaa atgtggatga gaaaatcgta agagaaattg atcgaagatg tgacgaacgg
    23401 ttctgttgca aagttttaaa tctactatca aataaggtag aataatagaa aaagatagca
    23461 ggaggaatga cgatgaatcc ttttaaagga aagcaatttc agcaggatgt gattattgta
    23521 gccgtgggct actatcttcg ttataacctt agctatcgtg aagttcaaga aatcttatat
    23581 gatcgtggca ttaacgtttc tcatacgacg atttatcgtt gggtgcaaga atatggcaaa
    23641 ctactctatc aaatttggaa aaagaaaaat aaaaaatcct tttattcatg gaaaatggat
    23701 gaaacgtaca tcaaaattaa aggaaaatgg cattatttgt atcgagccat cgatgcagat
    23761 ggtttaacct tggatatttg gttacgtaaa aaacgggaca cacaagcagc ctatgctttt
    23821 cttaagcggt tagtgaagca gtttgatgaa ccgaaggttg tagtcacaga taaagccccc
    23881 tctattacaa gtgcctttaa gaaactaaaa gaatacggct tttatcaagg aacagaacat
    23941 cgtaccatta aatacctgaa taatttgatt gaacaagacc atcgtccagt aaagagacgc
    24001 aataaattct atcgaagttt acgcactgcc tctaccacga ttaaaggcat ggaagccatt
    24061 cgaggattat ataagaaaac ccgaaaagaa ggcactctct tcgggttttc ggtctgtact
    24121 gaaatcaagg tattattggg aatcccagct taaatcatag ataccgtaag ggattttatt
    24181 ctttatttaa aactttgcaa cagaaccacc cgcactatgc cattacattt atatctacgc
    24241 gaattgtaaa attaagttag aaaaataaaa aggcatttat ggtacactca aattgtattt
    24301 ccgacgaaag aaaacaaagg agtgtaacca taaatgacct acaaacatct taccatagac
    24361 gaactgacaa tgatagaatc atattatctt caacataata agccggttga aatcgctaac
    24421 cgaatgggac gtgctataca aactatttat aatgtagtca ataagttcaa gcaaggcaag
    24481 actgctcttg attattggca ccagtataaa gaaaataaga aaaaatgtgg tagaaaagtc
    24541 attcaattac ctgctcatga agtagattac attaaagaga aagtcactct tggttggacg
    24601 cctgacgtca ttatcgggcg aaaagaaagg tctgtttcat gcggtatgag aacactttat
    24661 cgtttatttt ctaaaggaat atttgatatt gacacactac cgatgagagg taaaagaaaa
    24721 cccaatggcc atcaggaaaa acggggaaaa caacagtatc agcgctcaat ccatgatcga
    24781 tctgataatt atcctgattt caattctgag tttggtcacc ttgaaggtga tacgatcgtt
    24841 ggcattcatc ataaaagtgc cgtcattact ttagttgaaa gattatctaa agtcattatc
    24901 acgattaaac ccaacggccg taaggcatta gatattgaaa ctgcccttaa tcaatggttt
    24961 tctcgcttcc ctaaaaactt ctttaaatct attacgtttg actgtggaaa agaattttct
    25021 aactggaaag ccattagtaa ccaacatgat attgatatat attttgcgga ccctggaaca
    25081 ccttctcaac gcccattaaa cgagaattct aacgggattc tgcgtcgtaa tggactgccg
    25141 aaatcaatgg attttagaaa agtgaatcag acatttattt ccagtgtcag caatcaacgt
    25201 aatcatattc caagaaaatc attgaattac agaacaccaa tcgaaatatt tttgagctat
    25261 gtacaagaag cattttattc tagcttaatt tgacaaatca tactatgata cgtgtttgtt
    25321 tttctgtgct gtttagtgaa tgattagcag aaatatagag agtaagattt taattaatta
    25381 ttagggggag aaggagagag tagcccgaaa acttttagtt ggcttggact gaacgaagtg
    25441 agggaaaggc tactaaaacg tcgaggggca gtgagagcga agcgaacact tgatctttta
    25501 agttgctatc tttttaaggt caatagagta tacttatttg tcctaatatg gttttagcag
    25561 tataattgac ttggtgaata ggtcatttaa gttgggcata ataggaggag taaaatgaaa
    25621 aaatttattt atcgagtttt agaaaatgac gaagtggtgg ctatttttaa tgagcaacaa
    25681 tatgcgcaag attttatcgc ttacgaaaag acaatttctg ataagcaatt tgaaattgaa
    25741 aaagtagata tagctgattg gttattgcaa ccgagagaat tttagaggtt ggttgaaaat
    25801 ggctaaaatt ggttatgcac gtgtcagtag caaagaacag aacttagata gacaactgaa
    25861 agcgttagag ggcgtttcta aggtcttttc agacaaatta agcggtcaat cggtcgaacg
    25921 cccacaatta caagctatgc ttaactatat tcgtgaaggg gatatagttg ttgttactga
    25981 attagatcga ttaggacgaa ataataaaga attaacagaa ttgatgaatc aaattcaaat
    26041 taagggggca accctggaag tcttaaattt accctcaatg aatggtattg aagatgaaaa
    26101 tttaagacgg ctgattaata atttagtgat tgaattgtat aagtaccaag cggaatctga
    26161 acgcaaacga attaaagaac gccaagccca aggaattgaa attgctaaga aaaaaggaaa
    26221 attcaaaggg cgacaaccta aattcaaaga aaatgatcca cgtttacaac acgctttcga
    26281 tttatttttg aatggttgtt ccgataaaga agttgaagaa caaactggaa ttaatcgccg
    26341 aacgtttaga aggtatcgat caagatacaa cgtgacagta gatcaaagaa aaaaacaatg
    26401 aaaagaggga tagttaatga gtacggttat tttagctgaa aaaccaagcc aggcattagc
    26461 ctacgcaagt gctttaaaac aaagcaccaa aaaagacggt tattttgaga tcaaagaccc
    26521 actatttaca gatgaaacgt ttatcacctt tggttttggg catttagtcg aattagcaga
    26581 accaggtcat tataacgaaa agtggcagaa ctggaaactt gaatctttgc cgatttttcc
    26641 tgatcgatac gattttgaag ttgcaaaaga taagggaaag cagtttaaaa ttgttgctga
    26701 acttctcaaa aaggcaaata caattattgt cgcaacagat agcgacagag aaggtgaaaa
    26761 tatcgcctgg tcgattatcc ataaagcaaa tgccttttct aaagataaaa cgtataaaag
    26821 attatggatc aatagcttag aaaaagatgt gatccgaagc ggttttcaaa atttgcaacc
    26881 aggaatgaat tactatccct tttatcaaga agcgcaaaca cgccaaattg ccgattggtt
    26941 gatcggcatg aacgcaagcc ctttatatac cttgaattta caacaaaaag gcgtacaagg
    27001 tacattttca ttaggacgtg tacaaacacc gactttatat ctcatttatc aacgccagga
    27061 agcaatagaa aactttaaaa aagaaccttt tttcctgaat aattcatagt tttactaata
    27121 gtctttccta acattgattt aatagtcttt aaagtattct gcttcatcac ccattaggtg
    27181 atgaaaaaag aacccctttc tgatttagcg gacaaatact ttgacctaat ctcagaagat
    27241 ataaaagaaa aaataataaa atatccgatt tatactttgt ataaagaact aaagtagtta
    27301 gcaaatcatt tacagcaaat cactatgttc cacataccat tttacatact taccttatcc
    27361 acgacacatg ttgagatagt atcgaagata aagaaagttg ctccatgttg tttttgcgag
    27421 atggggaaat caaagccaca ttgacaacca tgatgaataa gcttgctttc agtcataagc
    27481 taatcctaga accacttttc aagtcagtta gccaaatcga tgaagaaagc gaccgtgaaa
    27541 gaatggacgc tattgataag ctaatggagc aactattgga agaacgcaat acccttattg
    27601 cactgatgtc caaaggtttc ctagaacctg ctctttttaa tcaggaacga aatgttttag
    27661 atagtgagat taaaaatctt actaccgaaa aaacaaacct ggtaacgaac tctgcgagtg
    27721 gggttttgcg agcaaacgag ataaaggacc tcattaatta tgtgtcagca gataatttta
    27781 atggtgacta cacggaagaa ctatttgaag aatttgtagt gaacatcatt gtaaattcca
    27841 gggatgagct gacattcaat ttgaaatgcg gtctttccct gaaagaaaag gtggtgagat
    27901 aaatggcata tattccatat ggatacaaaa ttcaagatgg agtggttact gtcgatgaaa
    27961 aggcagcagg tcaagtaaag gtattctttg agaaatacat atcaggacta tcccttacag
    28021 tggctggcga acaggcaggt attgaaaaga cacattctgt gatggggcgc attttgaaaa
    28081 acgtcaacta ccttggaaat gatacgtatc cagcaattat tgataaagag atatttgata
    28141 aagctgaaga agttagagat aaacgtgcaa aggatttagg acgagtggta gagcttgccg
    28201 ctttcacctc tccccctccc aaagaacgat tcaaaatgaa aaaggcagat aataagatgc
    28261 cagtggatcc ttttgaacga gcagaatact tatacagtct gatagaaagc gaggaataaa
    28321 gtgacagaga aaaatataat ggttattcct gctcgtaaaa gagtaggaag tacagccgca
    28381 aaagaaaaga taaagaaact tcgtgttgct gcctattgcc gtgtttctac agaaacagaa
    28441 gaacaaaatt ctagctatga ggttcaggtc tcacactata cagagtttat aaagaaaaat
    28501 aatgaatggg agtttgctgg catctttgca gatgatggta tctctggtac gaacact
//
