LOCUS       CP063559               28558 bp    DNA     circular BCT 04-APR-2022
DEFINITION  Enterococcus faecium strain BMT-1-1-10 plasmid pIN-1-10_04, complete
            sequence.
ACCESSION   CP063559
VERSION     CP063559.1
DBLINK      BioProject: PRJNA669626
            BioSample: SAMN16483164
KEYWORDS    .
SOURCE      Enterococcus faecium
  ORGANISM  Enterococcus faecium
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 28558)
  AUTHORS   Both,A., Kruse,F., Mirwald,N., Franke,G., Christner,M., Huang,J.,
            Hansen,J.L., Kroger,N., Berneking,L., Lellek,H., Aepfelbacher,M. and
            Rohde,H.
  TITLE     Population dynamics in colonizing vancomycin-resistant Enterococcus
            faecium isolated from immunosuppressed patients
  JOURNAL   J Glob Antimicrob Resist 28, 267-273 (2022)
   PUBMED   35134550
REFERENCE   2  (bases 1 to 28558)
  AUTHORS   Both,A., Kruse,F., Christner,M., Huang,J., Mirwald,N., Franke,G. and
            Rohde,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-OCT-2020) Institute of Medical Microbiology, Virology
            and Hygiene, University Medical Center Hamburg-Eppendorf,
            Martinistr. 52, Hamburg, Hamburg 20246, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Trycycler v. v0.3.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 510.0x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 10/27/2020 16:36:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.13
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 3,265
            CDSs (total)                      :: 3,174
            Genes (coding)                    :: 3,071
            CDSs (with protein)               :: 3,071
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 32 of 103
            Pseudo Genes (incomplete)         :: 65 of 103
            Pseudo Genes (internal stop)      :: 16 of 103
            Pseudo Genes (multiple problems)  :: 9 of 103
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..28558
                     /organism="Enterococcus faecium"
                     /mol_type="genomic DNA"
                     /strain="BMT-1-1-10"
                     /isolation_source="rectal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1352"
                     /plasmid="pIN-1-10_04"
                     /geo_loc_name="Germany: Hamburg"
                     /lat_lon="53.33 N 10.1 E"
                     /collection_date="2014-07-08"
                     /collected_by="Institute of Medical Microbiology, Virology
                     and Hygiene, University Medical Center Hamburg-Eppendorf"
     gene            join(28353..28558,1..610)
                     /locus_tag="IQN16_16080"
     CDS             join(28353..28558,1..610)
                     /locus_tag="IQN16_16080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002326780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC33581.1"
                     /translation="MVKIAGLSKGGKTVSQLYKQNYRDWRQFRKNIKDSYFILPTELEK
                     YLPNNKAINLYLYYCFKAKNEGGDSWHSVNTIAESLGVTTKTINTWNKTLVDLGMIARI
                     DDNHLSKSTILLPLSSYYKLALDSSLKDVTESTVHEIDGNLVAVYHLFEWRKNEADENY
                     NVPYNTLCCVFKRKTQKDTIYKFILVQDEKISNFELSTPSSKIYDDAYRFECQDLEALL
                     SANNLNNIEHENFVVNTRFNLVSEKDSDLLDLLIELTKNLDKKENITVL"
                     /name="hypothetical protein"
     gene            736..993
                     /locus_tag="IQN16_16085"
     CDS             736..993
                     /locus_tag="IQN16_16085"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC33600.1"
                     /translation="MANLYIENKGDLNAIITLIVVMVKSIGNITIGMLFIILAAVLIFM
                     IVIWFLNERSKDNQHRRDMEIKSIESIDYLSIITLKKPRS"
                     /name="hypothetical protein"
     gene            complement(1245..1817)
                     /locus_tag="IQN16_16090"
     CDS             complement(1245..1817)
                     /locus_tag="IQN16_16090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000170424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="UOC33582.1"
                     /translation="MTKYGYARVSTASQSTKEQIQQLLENGVEKKNIFSEKFTGTKRDR
                     PKFNQLLAGLKPGDEIVVTKLDRFARNTREALEIIEPLLDDNVTIKVLNLGTIENTSMG
                     RMVTRTLLSVAEMERDMIVERTQEGKMFARKNNPNFREGRPKATITPKKRHAYELLTSG
                     KSYKEVEAITGFSRSTLFRIKKKIEES"
                     /name="recombinase family protein"
     gene            complement(1833..2438)
                     /locus_tag="IQN16_16095"
     CDS             complement(1833..2438)
                     /locus_tag="IQN16_16095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016176895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell filamentation protein"
                     /protein_id="UOC33583.1"
                     /translation="MILENKLGLTNQVELAKVEEKLSKQKAKELYDCGKINEIEVGTFK
                     GLSEIHEFLFSDIYDFAGKIRSVNIAKGNFRFAPVMYLEHSLQHIDQMPQTSFEEIIKK
                     YVEMNIAHPFREGNGRSTRIWLDLILKEELQKVVDWNLIDKADYLSAMERSPINDLEIR
                     YLISNALTDKIDDRELYMKGIDVSYFYEGYSEYTIDDL"
                     /name="cell filamentation protein"
     gene            complement(2839..3456)
                     /locus_tag="IQN16_16100"
     CDS             complement(2839..3456)
                     /locus_tag="IQN16_16100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016175297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="UOC33598.1"
                     /translation="MDTVRDFILYLKLCNRTYYFKSEKDTSSLTLTLEEGVEPDKVTSK
                     VINQLKEKGSLKHLGEYEVLDTAMLTKGIGQILSTITYFITAVAGISLFIAGVGVMNMM
                     YISVSERTKEIGIRRALGATRKSIMLQFLLEGLILTLSGGLIGYLLGMALAYSVGSLIK
                     VNVSLDLFTILLAVGVSSVIGLVFSVMPASEAAKKDLIDILR"
                     /name="FtsX-like permease family protein"
     gene            complement(3460..4140)
                     /locus_tag="IQN16_16105"
     CDS             complement(3460..4140)
                     /locus_tag="IQN16_16105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="UOC33584.1"
                     /translation="MNPFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            4287..4370
                     /locus_tag="IQN16_16110"
     CDS             4287..4370
                     /locus_tag="IQN16_16110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001814874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA methyltransferase attenuation leader
                     peptide"
                     /protein_id="UOC33599.1"
                     /translation="MLVFQMRNVDKTSTVLKQTKNSDYADK"
                     /name="23S rRNA methyltransferase attenuation leader
                     peptide"
     gene            4495..5232
                     /gene="erm(B)"
                     /locus_tag="IQN16_16115"
     ARG             4496..5229
                     /name="erm(B)"
                     /gene="erm(B)"
                     /gene_name="23S rRNA (adenine(2058)-N(6))-methyltransferase
                     Erm(B)"
                     /tool="amrfinderplus"
                     /drug_class="LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(5495..6358)
                     /locus_tag="IQN16_16120"
     CDS             complement(5495..6358)
                     /locus_tag="IQN16_16120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010782381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zeta toxin family protein"
                     /protein_id="UOC33586.1"
                     /translation="MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSG
                     KTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELVKLYEKDVVKHVTPYSNRMTEALIS
                     RLSDQGYNLVIEGTGRTTDVPIQTATMLQSKGYETKIYVMAVPKIESYLGTIERYETMY
                     ADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISP
                     KETLERELNRKVSGKEIQPTLERIEQKMVQNQHQETPEFKAIQQKMESLQLPTPPIPKT
                     PKLPGI"
                     /name="zeta toxin family protein"
     gene            complement(6360..6632)
                     /locus_tag="IQN16_16125"
     CDS             complement(6360..6632)
                     /locus_tag="IQN16_16125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002333002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antitoxin"
                     /protein_id="UOC33587.1"
                     /translation="MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVN
                     LLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYSKQILNKEKVA"
                     /name="antitoxin"
     gene            complement(6649..6858)
                     /locus_tag="IQN16_16130"
     CDS             complement(6649..6858)
                     /locus_tag="IQN16_16130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000527318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-binding protein"
                     /protein_id="UOC33588.1"
                     /translation="MGNLGAQKAKRNDTPISAKKDIMGDKTVRVRADLHHIIKIETAKN
                     GGNVKEVMDQALEEYIRKYLPDKL"
                     /name="peptide-binding protein"
     gene            complement(6957..7853)
                     /locus_tag="IQN16_16135"
     CDS             complement(6957..7853)
                     /locus_tag="IQN16_16135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002355409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family protein"
                     /protein_id="UOC33589.1"
                     /translation="MIQYYYTKKEWGVVMEKEKLKILEELRRILNNKNEAIIILNNYFK
                     GGVGKSKLSTMFAYLTDKLNLKVLMIDKDLQATLTKDLAKTFEVELPRVNFYEGLKNGN
                     LASSIIHLTDNLDLIPGTFDLMLLPKLTRSWTFENESRLLATLLAPLKSDYDLIIIDTV
                     PTPSVYTNNAIVASDYVMIPLQAEEESTNNIQNYISYLIDLQEQFNPGLDMIGFVPYLV
                     DTDSATIKSNLEELYKEHKEDNLVFRNIIKRSNKVSTWSKNGITEHKGYDKKVLSMYEN
                     VFFEMIERIIQLENEKE"
                     /name="ParA family protein"
     gene            complement(8151..8723)
                     /locus_tag="IQN16_16140"
     CDS             complement(8151..8723)
                     /locus_tag="IQN16_16140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001079940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HTH domain-containing protein"
                     /protein_id="UOC33590.1"
                     /translation="MNRINRVTSILIQLQSKKIIPAKEIAQRFNISLRTVYRDIRTLEE
                     AGIPIGSEAGKGYFLVEGFLLPPVMFTAAEVGALITAGKFLNCHGDESFIKDFDSAMYK
                     IKSILKHGEKNYAQELENSINVYSTSGQKNTLADNVIAAIQTAICNKRVISIQYPASGG
                     QEPESRMIEPISLGFYEQNWYLIGFAG"
                     /name="HTH domain-containing protein"
     gene            complement(8999..9793)
                     /gene="aph(3')-IIIa"
                     /locus_tag="IQN16_16145"
     ARG             complement(9003..9793)
                     /name="aph(3')-IIIa"
                     /gene="aph(3')-IIIa"
                     /gene_name="aminoglycoside O-phosphotransferase
                     APH(3')-IIIa"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(9886..10428)
                     /gene="sat4"
                     /locus_tag="IQN16_16150"
     ARG             complement(9890..10428)
                     /name="sat4"
                     /gene="sat4"
                     /gene_name="streptothricin N-acetyltransferase Sat4"
                     /tool="amrfinderplus"
                     /drug_class="STREPTOTHRICIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(10425..11333)
                     /locus_tag="IQN16_16155"
     CDS             complement(10425..11333)
                     /locus_tag="IQN16_16155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032491779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside nucleotidyltransferase ANT(6)-Ia"
                     /protein_id="UOC33593.1"
                     /translation="MRSEKEMMDLVLSLAEQDERIRIVTLEGSRANINIPKDEFQDYDI
                     TYFVSDIEPFISNDDWLNQFGNIIMMQKPEDMELFPPEEKGFSYLMLFDDYNKIDLTLL
                     PLEELDNYLKGDKLIKVLIDKDCRIKRDIVPTDIDYHVRKPSAREYDDCCNEFWNVTPY
                     VIKGLCRKEILFAIDHFNQIVRHELLRMISWKVGIETGFKLSVGKNYKFIERYISEDLW
                     EKLLSTYRMDSYENIWEALFLCHQLFRAVSGEVAERLHYAYPEYDRNITKYTRDMYKKY
                     TGKTGCLDSTYAADIEERREQ"
                     /name="aminoglycoside nucleotidyltransferase ANT(6)-Ia"
     gene            complement(11366..12100)
                     /locus_tag="IQN16_16160"
     CDS             complement(11366..12100)
                     /locus_tag="IQN16_16160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016250180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="UOC33594.1"
                     /translation="MKENKYDDNIFFQKYSQMSRSQKGLAGAGEWETLKKMLPDFKGKR
                     VLDLGCGYGWHCIYAMENGASSVVGVDISHKMLEVAKGKTHFPQIEYECCAIEDVDFPE
                     ESFDVILSSLAFHYVADYENLIKKIYRMLKAGGNLVFTVEHPVFTAHGTQDWYYNEKGE
                     ILHFPVDNYYYEGKRTAMFLEEKVTKYHRTLTTYLNTLLSNSFIINQIVEPQPPENMMD
                     IPGMADEMRRPMMLIVSAKKKM"
                     /name="class I SAM-dependent methyltransferase"
     gene            complement(12081..12950)
                     /locus_tag="IQN16_16165"
     CDS             complement(12081..12950)
                     /locus_tag="IQN16_16165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002328890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase domain-containing protein"
                     /protein_id="UOC33595.1"
                     /translation="MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYY
                     NSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDWINGGGWLFINGYHVDLILRDIKRV
                     EQIMKDTEHGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAETYPNA
                     LQKSLVNFFMFEAGFSLMFVKANSGTDDKYYIAGHVFRIVSCLNQVLFACNNAYCINEK
                     KAIKLLETFEHKPEKYTEKVNHIFEVLGISLFECYDMTEKLYNEVNEIVSEINNFLNEE
                     SSDERKQI"
                     /name="nucleotidyltransferase domain-containing protein"
     gene            complement(12965..13189)
                     /locus_tag="IQN16_16170"
     CDS             complement(12965..13189)
                     /locus_tag="IQN16_16170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018579902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="UOC33596.1"
                     /translation="MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDE
                     LKAIADVLGVKFVQAFILPDGEEIKISNE"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(13332..14894)
                     /locus_tag="IQN16_16175"
     CDS             complement(13332..14894)
                     /locus_tag="IQN16_16175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="UOC33597.1"
                     /translation="MTEKNIMVIPARKRVGSTAAKEKIKKLRVAAYCRVSTETEEQNSS
                     YEVQVSHYTEFIKKNNEWEFAGIFADDGISGTNTKKRDEFNRMIAECMDGNIDMVITKS
                     ISRFARNTLDCLQYIRQLKDKNISVYFEKENINTTDAKGEVLLTIMASLAQQESQSLSQ
                     NVKLGLQYRYQQGKVQVNHKRFMGYTKDEDGNLTIVPEEAEIIKRIYREYLEGQSLVGI
                     GRALEKDGILTAAGKPRWRPESVKKILQNEKYIGDALLQKTVTVDFLTKKRVKNEGHVP
                     QYYVENSHEAIIPKELFLQAQEEIHRRSNIYTGEGKNKRIYSSKYALSAITFCGDCGDI
                     YRRVYWNIHGRKEFVWRCVTRIEQGPEVCKNRTVKEDELYGAVMTAINKLLAGGNNMIK
                     TLEENIHAVIGETTEYQISEINNSLEEKQKELIKLANKGQDYDHLADEIDELRDKRQIL
                     LVEDASLSGENERINELIEFIRKNKFRTLEYDDKLVRKIIQSVTVYEGHFVIAFKSGIE
                     MEI"
                     /name="recombinase family protein"
     gene            complement(14896..15312)
                     /locus_tag="IQN16_16180"
     CDS             complement(14896..15312)
                     /locus_tag="IQN16_16180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000323438.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase"
                     /protein_id="UOC33568.1"
                     /translation="MAYIPYGYKIQDGVVTVDEKAAGQVKVFFEKYISGLSLTVAGEQA
                     GIEKTHSVMGRILKNVNYLGNDTYPAIIDKEIFDKAEEVRDKRAKDLGRVVELAAFTSP
                     PPKERFKMKKADNKMPVDPFERAEYLYSLIESEE"
                     /name="recombinase"
     gene            complement(15313..15811)
                     /locus_tag="IQN16_16185"
                     /pseudo=""
     CDS             complement(15313..15811)
                     /locus_tag="IQN16_16185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002327635.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DNA recombinase"
                     /name="DNA recombinase"
     gene            complement(16122..16799)
                     /locus_tag="IQN16_16190"
                     /pseudo=""
     CDS             complement(16122..16799)
                     /locus_tag="IQN16_16190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000108743.1"
                     /note="incomplete; partial on complete genome; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase"
                     /name="DNA topoisomerase"
     gene            complement(16815..17417)
                     /locus_tag="IQN16_16195"
     CDS             complement(16815..17417)
                     /locus_tag="IQN16_16195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002333458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="UOC33569.1"
                     /translation="MAKIGYARVSSKEQNLDRQLKALEGVSKVFSDKLSGQSVERPQLQ
                     AMLNYIREGDIVVVTELDRLGRNNKELTELMNQIQIKGATLEVLNLPSMNGIEDENLRR
                     LINNLVIELYKYQAESERKRIKERQAQGIEIAKKKGKFKGRQPKFKENDPRLQHAFDLF
                     LNGCSDKEVEEQTGINRRTFRRYRSRYNVTVDQRKKQ"
                     /name="recombinase family protein"
     gene            complement(17431..17601)
                     /locus_tag="IQN16_16200"
     CDS             complement(17431..17601)
                     /locus_tag="IQN16_16200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000713595.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC33570.1"
                     /translation="MKKFIYRVLENDEVVAIFNEQQYAQDFIAYEKTISDKQFEIEKVD
                     IADWLLQPREF"
                     /name="hypothetical protein"
     gene            complement(17923..18882)
                     /locus_tag="IQN16_16205"
     CDS             complement(17923..18882)
                     /locus_tag="IQN16_16205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000221326.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
                     /protein_id="UOC33571.1"
                     /translation="MTYKHLTIDELTMIESYYLQHNKPVEIANRMGRAIQTIYNVVNKF
                     KQGKTALDYWHQYKENKKKCGRKVIQLPAHEVDYIKEKVTLGWTPDVIIGRKERSVSCG
                     MRTLYRLFSKGIFDIDTLPMRGKRKPNGHQEKRGKQQYQRSIHDRSDNYPDFNSEFGHL
                     EGDTIVGIHHKSAVITLVERLSKVIITIKPNGRKALDIETALNQWFSRFPKNFFKSITF
                     DCGKEFSNWKAISNQHDIDIYFADPGTPSQRPLNENSNGILRRNGLPKSMDFRKVNQTF
                     ISSVSNQRNHIPRKSLNYRTPIEIFLSYVQEAFYSSLI"
                     /name="IS30 family transposase"
     gene            complement(19063..19743)
                     /locus_tag="IQN16_16210"
     CDS             complement(19063..19743)
                     /locus_tag="IQN16_16210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="UOC33572.1"
                     /translation="MNPFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            complement(20105..20388)
                     /locus_tag="IQN16_16215"
                     /pseudo=""
     CDS             complement(20105..20388)
                     /locus_tag="IQN16_16215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002345737.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            complement(20409..21260)
                     /locus_tag="IQN16_16220"
     CDS             complement(20409..21260)
                     /locus_tag="IQN16_16220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002354342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC33573.1"
                     /translation="MKSDDWIEHTWLPLKRNSKRKKFWVLQLWPLGKLCSYGARLILDL
                     TVYSIGVFGTAYYLINDPNRIAASDIFTVLMTLIFVMLLSIFTQLVMQFTRQKLTAGKL
                     FKSLFDLIVVNAILATLIKQIEQSGRTTKGVKDFLLTFIHFVNGHMYLFEVGIILFFVG
                     YVSTKLIKRSIEKEIEIDLIPTLLGYEYNVDFGRYDELINTDIVHTSIHESTVKGIRSI
                     LKNGQEMKAIDRRKEIYNFYEVEASLRYGIGKLWLDGSNIRQNKPYIFWNSSDLELPMK
                     DK"
                     /name="hypothetical protein"
     gene            complement(21361..21657)
                     /locus_tag="IQN16_16225"
     CDS             complement(21361..21657)
                     /locus_tag="IQN16_16225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000053907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type III secretion system protein PrgN"
                     /protein_id="UOC33574.1"
                     /translation="MSLKNYVYSHPVNVFIIGRLGLSVEVFCELYGFKQGTLSSWVTRE
                     KTVASLPIEFLHGLSLASGETMDQVYDCLCVLEQEYIEYKIANELRKRKKYIQ"
                     /name="type III secretion system protein PrgN"
     gene            complement(21792..23285)
                     /locus_tag="IQN16_16230"
     CDS             complement(21792..23285)
                     /locus_tag="IQN16_16230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000947690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primase C-terminal domain-containing protein"
                     /protein_id="UOC33575.1"
                     /translation="MLSEIYSAILKNGLRTYKYRNSTMKPAGHIDSSRSGAIFAYRSKQ
                     LMNVGRGMVITSEEAILENEKKLTHWTPNTYRFGTYADDYRTVVKGHSEKNLSQINTFV
                     VDIDSKENHQGEIILACLDQVGYMPTLILESDHGYQVYFVLKTPGYVTKKSNFKVIDVA
                     KKISKTIRLQLAEKLSGVDLGCNHFGIARFPQENNIVFKEMNYQYSFADWIQWSMKLES
                     DQKTKEDRERKLIVFPEKKEIRQVDEPWFDMLLHKANIVGGEGRLGRNNVIFTLSLAYY
                     SSGYALDTCEYNMFTFNERLQEPLSEAELVKIVRSAYSGNYQAASREFIIELCQQWVSP
                     TLKNNDLFIQRRGWWKFKKPRDQRKYSHKNEWKEDLLAYLSEKSLASEPYLNLSKKELA
                     SQLTMPKRTLDKILNELREENKVFYKVTRGRNGGMIIASVKTLFARVIQLSKEKRLDYS
                     TRITEVFGLNESLVEETFRQLSTPLNPLKEVNLFEVDTG"
                     /name="primase C-terminal domain-containing protein"
     gene            23897..24850
                     /locus_tag="IQN16_16235"
     CDS             23897..24850
                     /locus_tag="IQN16_16235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016623100.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family protein"
                     /protein_id="UOC33576.1"
                     /translation="MENLRTAFKTSDKLGKVVMLTGRKGGIGKTTDNDLLAIVSSQLFE
                     KDVLLIDYDQQRNTTSNIGSTYQITSFDRSMSAAIKKGDWVSGITQVSPHLYIMAGSPG
                     SEELNEYLSEKYPDRRKRSLAFIKPLEELRKNFDYIFIDCPPSTDNVVRAFLTAADYII
                     AMQELKRYAMEGTEDFINKVLVPIVTNFEESHLQIIGILPVLFSVRRSSQHANYQKTID
                     KYGESNIFKSIVKGSDRLEMYGENGIQLNDYVDRRWWAIFADIFTELEERIEYYEQHGD
                     IEGFDYTPKYADSMANHILPLGKEIKLNGIITNEQR"
                     /name="ParA family protein"
     gene            24822..25097
                     /locus_tag="IQN16_16240"
     CDS             24822..25097
                     /locus_tag="IQN16_16240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001196543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type III secretion system protein PrgO"
                     /protein_id="UOC33577.1"
                     /translation="MALLPTNKDKKKIGAEDISIKDDINVELGERKYTAKERKPVQVDP
                     PVLKTIRDLSYAKDIPMYEIVKLAMDAYVDTLNDEERIIYNRRSKD"
                     /name="type III secretion system protein PrgO"
     gene            complement(26001..26171)
                     /locus_tag="IQN16_16245"
     CDS             complement(26001..26171)
                     /locus_tag="IQN16_16245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001021554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC33578.1"
                     /translation="MNIIQQYELKYITFDQLSEEIWGYGQRLINEVGVERFSFYVEAAA
                     GYHKYEYYIGY"
                     /name="hypothetical protein"
     gene            complement(26168..26518)
                     /locus_tag="IQN16_16250"
     CDS             complement(26168..26518)
                     /locus_tag="IQN16_16250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002359653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC33579.1"
                     /translation="MIDYNDRGRLKWAGFYLSDHTEKIDADNEQRANQNLAKEQMTTEE
                     VAEVLNAAVIKNRSVCIQKEERNAEGYYPEDIVSKILGSDELGIYVGKNKVHYDEIRHI
                     EFYQDNKWGRLE"
                     /name="hypothetical protein"
     gene            complement(26511..27836)
                     /locus_tag="IQN16_16255"
     CDS             complement(26511..27836)
                     /locus_tag="IQN16_16255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002335330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Y-family DNA polymerase"
                     /protein_id="UOC33580.1"
                     /translation="MMDYSKEPVNDYFLIDMKSFYASVECIERNLDPLTTELVVMSRAD
                     NTGSGLILASSPAAKKKYGISNVSRPRDLPQPFPKTLHVVPPRMNLYIKRNMQVNNIFR
                     RYVADEDLLIYSIDESILKVTRSMNLFTTEGTRSQRRKKLAQMIQENIKEELGLLATVG
                     VGDNPLLAKLALDNEAKHNDGFLAEWTYQNVPDKVWNIPEMTDLWGIGSRMKKRLNQIG
                     IMSIKDLANWNPYTIKSHLGVIGLQLYFHANGIDRTDIAIPPEPTKEKSYGNSQVLPRD
                     YTRRNEIELVVKEMAEQVAIRIRQHNCKTGCVHLYIGTSILETRPGFSHQMKIPITDNT
                     KELQNYCLFLFDKYYEGQEVRHVGITYSKLVYTDSLQLDLFSDPQKQIDEENLDKIIDK
                     IRQKYGFTSIVHASSMLEGARSITRSTLVGGHAGGAGGLKND"
                     /name="Y-family DNA polymerase"
     ARG             complement(10429..11333)
                     /name="ant(6)-Ia"
                     /gene="ant(6)-Ia"
                     /gene_name="aminoglycoside nucleotidyltransferase
                     ANT(6)-Ia"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             4496..5232
                     /name="ErmB"
                     /gene="ErmB"
                     /gene_name="Erm 23S ribosomal RNA methyltransferase"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; lincosamide antibiotic;
                     streptogramin antibiotic; streptogramin A antibiotic;
                     streptogramin B antibiotic"
                     /identity="98.37"
                     /coverage="98.79"
     ARG             complement(9887..10428)
                     /name="SAT-4"
                     /gene="SAT-4"
                     /gene_name="streptothricin acetyltransferase (SAT)"
                     /tool="rgi"
                     /drug_class="nucleoside antibiotic"
                     /identity="99.44"
                     /coverage="100.0"
     ARG             complement(10426..11333)
                     /name="aad(6)"
                     /gene="aad(6)"
                     /gene_name="ANT(6)"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="100.0"
                     /coverage="109.42"
     Typing          complement(21793..23285)
                     /name="rep_cluster_185"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.866"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 ttcctggcat tcggtcaata ccatagcaga gtctctagga gtgacaacta aaactataaa
       61 cacctggaat aaaaccttag ttgatttagg tatgattgca cgtatagacg ataaccatct
      121 cagtaaatcg acaattttac ttcctctctc tagttactat aaattagccc ttgatagttc
      181 tttaaaggat gttaccgaga gcactgtcca tgaaattgat ggcaacttgg ttgcagttta
      241 tcatttgttt gaatggagaa aaaatgaggc tgatgaaaat tataacgttc cttataacac
      301 actctgttgt gtttttaaaa gaaaaacaca aaaagatact atctataaat ttatcttggt
      361 ccaagatgag aaaataagta atttcgaatt aagcactcct tctagtaaga tttatgacga
      421 tgcatataga tttgaatgtc aagatctaga agccctcctt tccgcaaata atctaaacaa
      481 tatagaacat gaaaactttg ttgtaaacac tagatttaat ttagtttctg aaaaggactc
      541 agatttgtta gatttgctga tagagcttac taaaaatcta gataagaaag aaaacattac
      601 tgtactataa ctagcatcgg tccatcatta agtttggact attagaacac ttgctattac
      661 agaaaaaggt atgctagcca cgcttactat ttattggtat caaacaagta tcttaatttg
      721 aaaggaagat gatttatggc taatttatat atagagaaca aaggagactt gaatgccatt
      781 attactttaa tcgtagttat ggtaaaatca ataggtaata tcacaatagg aatgctgttt
      841 attatattag cagcagtgct gatttttatg atagttattt ggttcttaaa tgaaagatct
      901 aaagacaatc aacaccgtag ggatatggag ataaaatcaa tagagtcaat agattattta
      961 tcgataataa cactaaaaaa gccacgttcc taaacgtgac ttacgctgaa cgatatgtgt
     1021 tgtttggtag acgaacaaat cgttcattat aaatatatga tggtatccta atatagtaag
     1081 cgtggctagc atacctttaa ttactttacc ttttacagtt accatacaca ttttttgagc
     1141 agaaatcaag taaataaaaa aatattatat ttcacaacat gctaatagac tcatatctag
     1201 aacgcattaa gtatttacct gtctggttcg ctgagacttc ttttttaact ttcttcaatt
     1261 ttcttcttta ttctaaaaag cgtactgcga ctgaaaccgg ttatagcttc aacttcctta
     1321 tacgatttac ctgaagtaag cagttcatat gcgtgcctct tcttcggtgt gattgttgct
     1381 ttcggacgtc cttctctgaa attaggatta ttctttcttg caaacatttt tccttcttgg
     1441 gtacgttcca caatcatatc acgttccatt tctgctacac tcaacaacgt ccgtgtcacc
     1501 attcgcccca tggacgtatt ttcaatcgtt cctagattca aaaccttgat cgttacgtta
     1561 tcatcgagta aaggttcaat gatctctaat gcttctctcg tgttacgagc aaatcgatca
     1621 agcttcgtaa caactatttc atctccaggc ttcagaccag ccaacagctg attgaatttt
     1681 ggccgatccc gttttgtacc cgtaaatttt tctgaaaaaa tattcttctt ctctacgccg
     1741 ttctcaagca actgttgaat ttgttctttt gtactttgag aagcggttga gacacgtgca
     1801 tatccatatt tcgtcatttg gtccacctac ttttacaaat catctatcgt atactcagaa
     1861 tacccttcat agaaatagct gacatcgatt cctttcatat ataactcgcg atcgtcaatt
     1921 ttatcagtca gagcattgga aattagatag cgtatttcca aatcgtttat gggacttcgc
     1981 tccattgcag aaagatagtc tgctttatcg attaagttcc aatctacaac tttttgcaat
     2041 tcttccttta aaatgagatc cagccaaatt ctagtacttc ggccatttcc ttctcgaaat
     2101 gggtgagcga tattcatctc cacatatttc ttgataatct cttcaaaaga agtttgtggc
     2161 atctgatcaa tatgctgtaa cgaatgttct aaatacataa ctggtgcaaa tcgaaaattt
     2221 ccttttgcaa tattgaccga tcggattttt ccggcaaaat cgtaaatatc cgaaaataga
     2281 aattcatgaa tttcagataa acctttaaat gtaccaactt cgatttcatt tatttttcca
     2341 caatcgtaca attctttcgc tttttgttta ctgagttttt cttcaacctt agccaactca
     2401 acttgattgg ttaatcccaa tttattctct aaaatcatgc gaaatctcct taactttatg
     2461 acataagttt atgaaacact ctcaacccca ttatatcgcg attttgttta tgtgtcaaaa
     2521 actattaagt ttctgacccc cgatagattt ttcaagtgtc tctattttgc acagtctagt
     2581 tgacctttga tacacctcta tatttataga gaatctaaaa catcaacatg gcatactcaa
     2641 aattctaaat attagggata aagaattctc ctatacaatc aaaaatttcc tttatttcga
     2701 actccggtca cctaactcta ttgatctctt acaagccaaa gaatatctct atactacaaa
     2761 gaaacaatag ggtgcctggt tggtctcttt gtgttttatt ttagaatcta gaacgtaaat
     2821 attcttgtca ttctgatttt atctaagaat atcaattaaa tctttttttg cagcctctga
     2881 agcgggcatt acagaaaaga ccagtccaat aaccgaagat accccaaccg ctagtaaaat
     2941 agtaaataga tcaagtgaca cgtttacctt tatcaaagaa ccaacactat aagcaagagc
     3001 cattcctaat aaatagccaa ttaaccctcc tgaaagagtt aaaatcaaac cttctaaaag
     3061 gaactgcagc ataatcgatt ttcgagtagc tcctagggct cttcttatac cgatctcttt
     3121 tgttcgttca gatacagata tatacatcat gttcattaca cctacccctg cgataaataa
     3181 agatatacct gctacagctg ttataaaata agtgatcgta ctgaggattt gaccaattcc
     3241 tttcgttaac atagccgtat ctaacacttc atattccccc aaatgtttca aactaccttt
     3301 ttctttcaat tggtttatca ctttagaggt caccttgtca ggttcaactc cttcctctaa
     3361 agttaacgtt agagacgatg tatccttttc agacttaaaa taataggttc tgttgcaaag
     3421 ttttaaataa agaataaaat cccttacggt atctatgatt taagctggga ttcccaataa
     3481 taccttgatt tcagtacaga ccgaaaaccc gaagagagtg ccttcttttc gggttttctt
     3541 atataatcct cgaatggctt ccatgccttt aatcgtggta gaggcagtgc gtaaacttcg
     3601 atagaattta ttgcgtctct ttactggacg atggtcttgt tcaatcaaat tattcaggta
     3661 tttaatggta cgatgttctg tcccttgata aaagccgtat tcttttagtt tcttaaaggc
     3721 acttgtaata gagggggctt tatctgtgac tacaaccttc ggttcatcaa actgcttcac
     3781 taaccgctta agaaaagcat aggctgcttg tgtgtcccgt tttttacgta accaaatatc
     3841 caaggttaaa ccatctgcat cgatggctcg atacaaataa tgccattttc ctttaatttt
     3901 gatgtacgtt tcatccattt tccatgaata aaaggatttt ttatttttct ttttccaaat
     3961 ttgatagagt agtttgccat attcttgcac ccaacgataa atcgtcgtat gagaaacgtt
     4021 aatgccacga tcatataaga tttcttgaac ttcacgatag ctaaggttat aacgaagata
     4081 gtagcccacg gctacaataa tcacatcctg ctgaaattgc tttcctttaa aaggattcat
     4141 cgtcattcct cctgctatct ttttctatta ttctacctta tttgatagta gatttaaaac
     4201 tttgcaacag aaccaaaatt ttgtataata ggaattgaag ttaaattaga tgctaaaaat
     4261 ttgtaattaa gaaggaggga ttcgtcatgt tggtattcca aatgcgtaat gtagataaaa
     4321 catctaccgt tttgaaacag actaaaaaca gtgattacgc agataaataa atacgttaga
     4381 ttaattccta ccagtgacta atcttatgac tttttaaaca gataactaaa attacaaaca
     4441 aatcgtttaa cttctgtatt tgtttataga tgtaatcact tcaggagtga ttacatgaac
     4501 aaaaatataa aatattctca aaacttttta acgagtgaaa aagtactcaa ccaaataata
     4561 aaacaattga atttaaaaga aaccgatacc gtttacgaaa ttggaacagg taaagggcat
     4621 ttaacgacga aactggctaa aataagtaaa caggtaacgt ctattgaatt agacagtcat
     4681 ctattcaact tatcgtcaga aaaattaaaa ctgaacactc gtgtcacttt aattcaccaa
     4741 gatattctac agtttcaatt ccctaacaaa cagaggtata aaattgttgg gaatattcct
     4801 taccatttaa gcacacaaat tattaaaaaa gtggtttttg aaagccatgc gtctgacatc
     4861 tatctgattg ttgaagaagg attctacaag cgtaccttgg atattcaccg aacactaggg
     4921 ttgctcttgc acactcaagt ctcgattcag caattgctta agctgccagc ggaatgcttt
     4981 catcctaaac caaaagtaaa cagtgtctta ataaaactta cccgccatac cacagatgtt
     5041 ccagataaat attggaagct atatacgtac tttgtttcaa aatgggtcaa tcgagaatat
     5101 cgtcaactgt ttactaaaaa tcagtttcat caagcaatga aacacgccaa agtaaacaat
     5161 ttaagtaccg ttacttatga gcaagtattg tctattttta atagttatct attatttaac
     5221 gggaggaaat aattctatga gtcgcttttg taaatttgga aagttacacg ttactaaagg
     5281 gaatgtagat aaattattag gtatagggca cctctaataa ctaccaatta attcacctca
     5341 aaatgaaatt agaaaaaaac agcgaaattt ttaaatctat ttcttatcga tacaaattcc
     5401 tcgtaggcgc tcgggacccc aacatgagga aatgttttta taaaaaaaga gtagttaccg
     5461 ttttttggta actactcttt tcctttttta aggtttaaat acctggaagt ttaggtgttt
     5521 tgggtattgg tggtgtaggt agctgcaagc tttccatttt ttgttgaatt gctttaaatt
     5581 caggggtttc ttggtgttga ttttgaacca ttttttgctc tattctctcc aaagtcggtt
     5641 gaatttcttt ccctgatact ttacgattta attctctttc taaggtctct ttcggactaa
     5701 tggaaggcgt ttctaagctt gaatagagtt tcactccttc tctattgtaa agccttatat
     5761 cgctaaataa gcccgtttta tgaagggttt ctaaattggt cggtaagttt ttgacaacaa
     5821 tatcatgcgc ttgttttggt gttgccctag ctgtcattgg atcatctgca tacatggttt
     5881 catatcgttc aatcgttcct aagtatgatt caattttcgg tactgccatg acgtatattt
     5941 ttgtttcata acctttagat tgaagcattg tggctgtttg aatgggaacg tctgttgttc
     6001 gtcctgttcc ttcaatcact aaattatagc cttgatcgct taaacggcta ataagtgctt
     6061 ctgtcatgcg attcgaataa ggggtaacgt gttttactac gtctttttca tagagtttca
     6121 ctaattcgtc aaaatttggg tgctgttgtt taaaggtatc attatcaatg acaataacat
     6181 tcccttgtgt ttcttcaaaa attgctgatc gcaaactggt tttccctgac cctggttgcc
     6241 caccaagtaa aaaagcggtt ggcgattcaa ccgctagtct atttttagtt agtcgttcaa
     6301 cattcttttc taaacgatct tcaaattgct tttcggtgaa gtcagtaata ttcgccatgt
     6361 taagccactt tctctttatt caaaatttgt tttgaatatt gattcattga ccgccaatac
     6421 tcatgaatag cttgtaattc ttcaaatggt tgttgaaata aatcaacttc ttgtgccact
     6481 tctaattgat ttaaaagatt cacttctagt aaacgagtat ttttagtatc tagttcatga
     6541 ttcaaaacat aatttaatac ccgattataa acacttgccg ataactcatt aatgatttca
     6601 atttcaaatg ttttttcata cgtaactgcc atttcatttt cactcctttt aaagtttgtc
     6661 aggtaaatat ttccgtatat attcttctaa ggcttgatcc ataacttctt ttacgtttcc
     6721 gccattcttt gctgtttcga tttttatgat atggtgcaag tcggcacgaa cacgaaccgt
     6781 cttatccccc attatatctt tttttgcgct gattggcgta tcatttcgtt ttgctttctg
     6841 tgcgcctaaa tttcccacga tcgctcactt ctttctattt cttcttacta tttattttat
     6901 catcacctat cacaaatcac aagtgatttg tgattaatca cttgtgattt gtgattctat
     6961 tctttttcat tttctaattg aatgattcgc tcaatcattt caaaaaatac gttctcatac
     7021 atagacaaaa cttttttgtc atagcctttg tgttctgtaa tgccattttt agaccaagta
     7081 cttactttat tacttcgctt gataatattt cggaaaacca aattatcctc tttatgttct
     7141 ttgtacagtt cttccaggtt tgattttatc gttgcgctgt ccgtatcaac taaataagga
     7201 acaaaaccaa tcatatctag tccagggtta aactgttctt gcaaatcaat caaataggaa
     7261 atatagtttt gaatgttgtt tgtactttct tcttctgctt gtaaagggat cataacgtaa
     7321 tcactcgcca cgattgcatt atttgtataa acgcttggcg ttggtacagt atcaataata
     7381 ataagatcat agtcactttt taaaggtgct aaaagagtag caagcaatct actttcattt
     7441 tcaaacgtcc atgagcgagt taattttggc agtaacatca aatcaaacgt gccagggatc
     7501 aagtctaaat tatcagtcaa atgaataata gaagaagcca agtttccatt tttcaagcct
     7561 tcataaaaat tgacacgtgg caattctacc tcaaaagttt ttgctaagtc ttttgtcaat
     7621 gttgcctgta agtccttatc gatcattaaa acttttaaat tcaatttgtc tgtcaagtaa
     7681 gcaaacatag tcgataattt ggactttcca acaccacctt taaagtaatt attcaagata
     7741 ataattgctt catttttatt gtttaaaata cgtcttaatt cttcaagtat ttttagtttt
     7801 tccttctcca taactacgcc ccattctttt tttgtatagt aatattgtat cattaagaat
     7861 cacaaatcac aagtgatttg tgattaatca cttgtgattt gtgataagtg atttgtgatt
     7921 aatatataaa agccctcttt aaagggcttt tatatttatt ttgagaaaga tataaaatca
     7981 atatatccct tttccccaat ttttacaacg gcattgtagg gcatatagtt ttttatatga
     8041 aagcatttgt tttaatattt gttccaaaga gccatcatgg ctttgacaga gctcttcttc
     8101 tatgcaaatg cttttaatcc gatccacacg aaaattccta tattcatttc ttagcctgca
     8161 aaaccgatta agtaccagtt ctgttcataa aaccccagtg atataggctc tatcattctg
     8221 ctttccggtt cttgccctcc tgatgcagga tattgaattg atattaccct tttattgcag
     8281 attgcagtct gaattgctgc aataacgtta tccgccaatg tatttttctg tccagatgtg
     8341 ctgtacacgt taatactgtt ctccaactcc tgtgcatagt ttttttcacc atgcttcaaa
     8401 atagatttga ttttatacat agctgaatca aaatccttta taaatgattc atctccatgg
     8461 caatttaaaa atttccctgc tgtaatcaat gcacccactt ccgccgctgt aaacattacc
     8521 ggcggaagta ggaagccctc tacaagaaaa tatccttttc cggcctcaga tccaattggt
     8581 attccggctt cttcaagtgt ccggatatct ctgtaaactg tccttaagct tatattaaat
     8641 cgctgtgcaa tttctttggc aggaattatt ttttttgatt gcagctgaat aagaatagag
     8701 gttactctgt taatcctgtt caaattttat tcctcctctg tgacttccat aaaaagtata
     8761 tcctatgcgt tcttaagcta gctgctgtta gtgcttctca ttgcaccctg gttataaaag
     8821 ccatactcac aaacctcttc accaaaactc tttacatctc taatatagaa ctctatctag
     8881 cgaactttta gaaaagatat aaaacatcag agtatggaca gttgcggatg tacttcagaa
     8941 aagattagat gtctaaaaag cttgtagtta aagcttttta gacatctaaa tctaggtact
     9001 aaaacaattc atccagtaaa atataatatt ttattttctc ccaatcaggc ttgatcccca
     9061 gtaagtcaaa aaatagctcg acatactgtt cttccccgat atcctccctg atcgaccgga
     9121 cgcagaaggc aatgtcatac cacttgtccg ccctgccgct tctcccaaga tcaataaagc
     9181 cacttacttt gccatctttc acaaagatgt tgctgtctcc caggtcgccg tgggaaaaga
     9241 caagttcctc ttcgggcttt tccgtcttta aaaaatcata cagctcgcgc ggatctttaa
     9301 atggagtgtc ttcttcccag ttttcgcaat ccacatcggc cagatcgtta ttcagtaagt
     9361 aatccaattc ggctaagcgg ctgtctaagc tattcgtata gggacaatcc gatatgtcga
     9421 tggagtgaaa gagcctgatg cactccgcat acagctcgat aatcttttca gggctttgtt
     9481 catcttcata ctcttccgag caaaggacgc catcggcctc actcatgagc agattgctcc
     9541 agccatcatg ccgttcaaag tgcaggacct ttggaacagg cagctttcct tccagccata
     9601 gcatcatgtc cttttcccgt tccacatcat aggtggtccc tttataccgg ctgtccgtca
     9661 tttttaaata taggttttca ttttctccca ccagcttata taccttagca ggagacattc
     9721 cttccgtatc ttttacgcag cggtattttt cgatcagttt tttcaattcc ggtgatattc
     9781 tcattttagc catttattat ttccttcctc ttttctacag tatttaaaga taccccaaga
     9841 agctaattat aacaagacga actccaattc actgttcctt gcattctaaa accttaaata
     9901 ccagaaaaca gctttttcaa agttgttttc aaagttggcg tataacatag tatcgacgga
     9961 gccgattttg aaaccacaat tatgatagaa tttacaagct ataaggttat tgtcctgggt
    10021 ttcaagcatt agtccatgca agtttttatg ctttgcccat tctatagata tattgataag
    10081 cgcgctgcct atgccttgcc ccctgaaatc cttacatacg gcgatatctt ctatataagc
    10141 gtaccggttc caattttttc gcagtttaac ttttccgacg catttatcgt cttggtagta
    10201 aagatatatt atcttatcag tattgtcaat atattcaagg caatctgcct cctcatcctc
    10261 ttcatcctct tcgtcttggt agctttttaa atatggcgct tcatagagta attctgtaaa
    10321 ggtccaattc tcgttttcat acctcggtat aatcttacct atcacctcaa atggttcgct
    10381 gggtttatcg atatctttca ggtgccctgc tttcatttct gtaatcactg ttcccgcctc
    10441 tcttctatat cagcggcata tgtgctatcc aggcagccgg ttttaccagt gtatttttta
    10501 tacatgtccc tggtatattt tgttatattc ctatcatact ccggataggc ataatgaagc
    10561 ctttccgcca cctcaccgga taccgccctg aacaattgat ggcatagaaa taatgcttcc
    10621 catatgtttt cataggaatc catccggtag gtggacaaaa gtttctccca caaatcctcg
    10681 gatatatacc tttcaataaa cttatagttc ttgcctacac ttaatttaaa gcctgtttcg
    10741 atgccgacct tccatgatat cattctcagc agctcatggc gaacaatctg attaaaatga
    10801 tcaatagcaa ataaaatttc cttacggcac aatcctttaa taacataagg tgttacattc
    10861 caaaattcat tgcagcaatc atcatactcc cttgcgcttg gctttcttac atgataatct
    10921 atatcagtcg gaactatgtc ccttttaatt ctacaatctt tatcaattag aacctttatt
    10981 aatttatcgc cctttaggta attatctaac tcttccaagg gcaataaggt aagatcaatt
    11041 ttattgtaat catcaaatag cataagatag gaaaatccct tttcttcagg tgggaataat
    11101 tccatatcct ccggcttttg catcattatt atattcccaa attgattaag ccagtcatca
    11161 ttagatataa acggttctat atcacttaca aaatatgtaa tatcataatc ctgaaattca
    11221 tctttaggta tattaatatt tgcgcgtgac ccctcaaggg tcacaattcg aatacgttca
    11281 tcctgttctg ctaaagaaag tactaaatcc atcatttctt tttctgatct catttacata
    11341 ctcctcgttt attttttcta tattattaca tcttcttttt tgccgataca atcagcatca
    11401 ttgggcgtcg catttcatcc gccatccccg gaatatccat catgttctct ggcggctgtg
    11461 gctccacaat ctgatttatt ataaaactat ttgaaagcag tgtatttaga tatgtggtca
    11521 gtgttctatg atattttgta accttttctt ccaaaaacat agctgtccgt ttgccctcat
    11581 aataataatt gtccaccggg aaatgcagta tttctccttt ttcgttataa taccagtctt
    11641 gtgttccatg agcagtaaaa acaggatgtt caactgtaaa aactaaattg ccaccagcct
    11701 tcagcatcct atatatcttt tttattaaat tctcatagtc tgctacataa tgaaacgcaa
    11761 gcgaacttag tattacatca aagctctcct ctgggaaatc cacatcttct atggcacagc
    11821 attcatattc aatctgtgga aaatgggttt ttccttttgc tacttcgagc attttatgag
    11881 aaatatcaac acctactaca gaggaagcac cgttttccat cgcatatata cagtgccatc
    11941 catagccgca tcctaaatca agcacacgct tacccttaaa atcaggtagc atctttttca
    12001 aagtctccca ttctcccgca ccagccagtc ctttctgcga gcgactcatt tgactgtatt
    12061 tttgaaaaaa tatattatca tcatatttgt tttctttcat ctgaactctc ctcgtttaaa
    12121 aagttattta tctccgatac aatttcattc acttcattat aaagcttctc ggtcatgtcg
    12181 tagcattcaa aaagtgagat accgagtact tcaaaaatat gatttacctt ctcggtatat
    12241 ttttcaggtt tatgttcaaa agtttcaagc agttttatag ctttcttttc gttgatacaa
    12301 taagcattat tacatgcaaa taacacttga tttaaacatg aaactatacg aaaaacatga
    12361 cccgcaatat aatatttatc gtctgttccc gaatttgctt ttacaaacat taaagagaac
    12421 cctgcttcaa acataaaaaa gttaactaaa cttttctgca aagcattggg ataagtttct
    12481 gcctgttttt ttaattcgca taagctttca ttcttagcat atagtatttt gctaatcgct
    12541 aattctcctc gatacattgc actaatataa ccatggggat gcccagtctg ataattggca
    12601 gtaacaattc cgtgctctgt atctttcatt atttgttcca cacgtttaat atcacgtaaa
    12661 attaaatcca catgataccc atttataaat aaccatccgc cgccattaat ccaatcaccc
    12721 cacgctccgg gaggcacaac aaggttgttt ctatttttat catccaattc tgtagcaatt
    12781 tgattaatcg ctgtcaggtc aaatgagtct gaattgtaat agattccgat atctatatca
    12841 gaattttctg tatgggtgcc tcttgcacgt gagcccccta atacgatgcc ttctataaaa
    12901 ggcaaagatg ataatttctc tgttactatt tgaataacat tacctaccat ataaacatcc
    12961 tcctttattc gttagatatt tttatttctt ctccatctgg taaaataaat gcctgcacaa
    13021 acttgacacc tagcacatca gcaatggcct tcaactcatc caaggttact gtttctcgtt
    13081 gtaatttttt attgaaattc tgtggagtct ggccaatacg tctagcaagt tcggaaacac
    13141 ttatattcat ttgctcacac agttctttaa tcatttctgc cgtagtcata cagcacctcc
    13201 aagtttacgc taagaatatt ataaaccatt tggttgataa acacaatagt tattaaaata
    13261 ttattataat cagcaagcaa aagaaaaccc acaactctac tgtagagtca tgggctattt
    13321 acttctggtt ttcatatttc catttcgatg ccagatttga aggctatgac gaagtggcct
    13381 tcatagactg taacgctctg gattatcttc cttacaagct tatcatcata ttctaaggtg
    13441 cggaatttgt tcttgcggat aaattcaatc agctcattga ttcgctcgtt ctcgccactg
    13501 agggaggcat cttctactaa aaggatctgt cgcttgtctc tcagctcatc aatctcatct
    13561 gctaagtggt catagtcttg acccttgttc gccagcttga ttagttcttt ttgtttttcc
    13621 tctagtgagt tgttaatctc tgaaatttgg tattctgtgg tttcgccaat cacagcatga
    13681 atattctctt ccagtgtctt tatcatattg ttcccacctg caagtagctt attaatcgca
    13741 gtcattactg caccataaag ttcatcttct tttacggttc ggttcttaca aacttcagga
    13801 ccttgctcga ttctagtcac gcatcgccag acaaattctt ttcttccgtg gatattccaa
    13861 tagacccgtc tataaatatc gccacaatct ccacagaagg tgatggcact taaagcgtac
    13921 ttgctactgt aaattctttt gttcttgcct tctcctgtgt agatattgct tctccgatga
    13981 atttcttctt gcgcctgcaa aaataactct ttaggaataa tcgcttcatg gctattttca
    14041 acataatatt ggggaacatg cccttcattt ttcactcgtt tcttggtcag aaaatctact
    14101 gtgacagtct tttgcagaag ggcatctccg atgtattttt cgttttgaag tatcttctta
    14161 actgattctg gtcgccatct tggttttccc gctgctgtta aaataccatc cttttcaagg
    14221 gctcgaccaa tgcccactag actctgaccc tcaaggtatt ctcggtagat gcgtttgata
    14281 atctcagctt cttcggggac aatagttaaa tttccatctt catctttcgt gtagcccata
    14341 aatcgcttat ggttgacctg cacctttcct tgttggtatc ggtactgtag cccaagctta
    14401 acgttttgtg aaaggctctg gctttcctgc tgtgccaaag atgccataat agtcagcaaa
    14461 acctcacctt tggcatccgt ggtgttgatg ttctctttct caaaataaac tgatatgttc
    14521 ttatccttga gctgtctaat gtattgaagg cagtctaggg tgttacgcgc aaatcggctg
    14581 atggattttg taataaccat gtcgatgtta ccgtccatac actctgcaat catgcgatta
    14641 aattcgtcac gctttttagt gttcgtacca gagataccat catctgcaaa gatgccagca
    14701 aactcccatt cattattttt ctttataaac tctgtatagt gtgagacctg aacctcatag
    14761 ctagaatttt gttcttctgt ttctgtagaa acacggcaat aggcagcaac acgaagtttc
    14821 tttatctttt cttttgcggc tgtacttcct actcttttac gagcaggaat aaccattata
    14881 tttttctctg tcactttatt cctcgctttc tatcagactg tataagtatt ctgctcgttc
    14941 aaaaggatcc actggcatct tattatctgc ctttttcatt ttgaatcgtt ctttgggagg
    15001 gggagaggtg aaagcggcaa gctctaccac tcgtcctaaa tcctttgcac gtttatctct
    15061 aacttcttca gctttatcaa atatctcttt atcaataatt gctggatacg tatcatttcc
    15121 aaggtagttg acgtttttca aaatgcgccc catcacagaa tgtgtctttt caatacctgc
    15181 ctgttcgcca gccactgtaa gggatagtcc tgatatgtat ttctcaaaga atacctttac
    15241 ttgacctgct gccttttcat cgacagtaac cactccatct tgaattttgt atccatatgg
    15301 aatatatgcc atttatctca ccaccttttc tttcagggaa agaccgcatt tcaaattgaa
    15361 tgtcagctca tccctggaat ttacaatgat gttcactaca aattcttcaa atagttcttc
    15421 cgtgtagtca ccattaaaat tatctgctga cacataatta atgaggtcct ttatctcgtt
    15481 tgctcgcaaa accccactcg cagagttcgt taccaggttt gtttttttcg gtagtaagat
    15541 ttttaatctc actatctaaa acatttcgtt cctgattaaa aagagcaggt tctaggaaac
    15601 ctttggacat cagtgcaata agggtattgc gttcttccaa tagttgctcc attagcttat
    15661 caatagcgtc cattctttca cggtcgcttt cttcatcgat ttggctaact gacttgaaaa
    15721 gtggttctag gattagctta tgactgaaag caagcttatt catcatggtt gtcaatgtgg
    15781 ctttgatttc cccatctcgc aaaaacaaca tggagcaact ttctttatct tcgatactat
    15841 ctcaacatgt gtcgtggata aggtaagtat gtaaaatggt atgtggaaca tagtgatttg
    15901 ctgtaaatga tttgctaact actttagttc tttatacaaa gtataaatcg gatattttat
    15961 tattttttct tttatatctt ctgagattag gtcaaagtat ttgtccgcta aatcagaaag
    16021 gggttctttt ttcatcacct aatgggtgat gaagcagaat actttaaaga ctattaaatc
    16081 aatgttagga aagactatta gtaaaactat gaattattca ggaaaaaagg ttctttttta
    16141 aagttttcta ttgcttcctg gcgttgataa atgagatata aagtcggtgt ttgtacacgt
    16201 cctaatgaaa atgtaccttg tacgcctttt tgttgtaaat tcaaggtata taaagggctt
    16261 gcgttcatgc cgatcaacca atcggcaatt tggcgtgttt gcgcttcttg ataaaaggga
    16321 tagtaattca ttcctggttg caaattttga aaaccgcttc ggatcacatc tttttctaag
    16381 ctattgatcc ataatctttt atacgtttta tctttagaaa aggcatttgc tttatggata
    16441 atcgaccagg cgatattttc accttctctg tcgctatctg ttgcgacaat aattgtattt
    16501 gcctttttga gaagttcagc aacaatttta aactgctttc ccttatcttt tgcaacttca
    16561 aaatcgtatc gatcaggaaa aatcggcaaa gattcaagtt tccagttctg ccacttttcg
    16621 ttataatgac ctggttctgc taattcgact aaatgcccaa aaccaaaggt gataaacgtt
    16681 tcatctgtaa atagtgggtc tttgatctca aaataaccgt cttttttggt gctttgtttt
    16741 aaagcacttg cgtaggctaa tgcctggctt ggtttttcag ctaaaataac cgtactcatt
    16801 aactatccct cttttcattg tttttttctt tgatctactg tcacgttgta tcttgatcga
    16861 taccttctaa acgttcggcg attaattcca gtttgttctt caacttcttt atcggaacaa
    16921 ccattcaaaa ataaatcgaa agcgtgttgt aaacgtggat cattttcttt gaatttaggt
    16981 tgtcgccctt tgaattttcc ttttttctta gcaatttcaa ttccttgggc ttggcgttct
    17041 ttaattcgtt tgcgttcaga ttccgcttgg tacttataca attcaatcac taaattatta
    17101 atcagccgtc ttaaattttc atcttcaata ccattcattg agggtaaatt taagacttcc
    17161 agggttgccc ccttaatttg aatttgattc atcaattctg ttaattcttt attatttcgt
    17221 cctaatcgat ctaattcagt aacaacaact atatcccctt cacgaatata gttaagcata
    17281 gcttgtaatt gtgggcgttc gaccgattga ccgcttaatt tgtctgaaaa gaccttagaa
    17341 acgccctcta acgctttcag ttgtctatct aagttctgtt ctttgctact gacacgtgca
    17401 taaccaattt tagccatttt caaccaacct ctaaaattct ctcggttgca ataaccaatc
    17461 agctatatct actttttcaa tttcaaattg cttatcagaa attgtctttt cgtaagcgat
    17521 aaaatcttgc gcatattgtt gctcattaaa aatagccacc acttcgtcat tttctaaaac
    17581 tcgataaata aattttttca ttttactcct cctattatgc ccaacttaaa tgacctattc
    17641 accaagtcaa ttatactgct aaaaccatat taggacaaat aagtatactc tattgacctt
    17701 aaaaagatag caacttaaaa gatcaagtgt tcgcttcgct ctcactgccc ctcgacgttt
    17761 tagtagcctt tccctcactt cgttcagtcc aagccaacta aaagttttcg ggctactctc
    17821 tccttctccc cctaataatt aattaaaatc ttactctcta tatttctgct aatcattcac
    17881 taaacagcac agaaaaacaa acacgtatca tagtatgatt tgtcaaatta agctagaata
    17941 aaatgcttct tgtacatagc tcaaaaatat ttcgattggt gttctgtaat tcaatgattt
    18001 tcttggaata tgattacgtt gattgctgac actggaaata aatgtctgat tcacttttct
    18061 aaaatccatt gatttcggca gtccattacg acgcagaatc ccgttagaat tctcgtttaa
    18121 tgggcgttga gaaggtgttc cagggtccgc aaaatatata tcaatatcat gttggttact
    18181 aatggctttc cagttagaaa attcttttcc acagtcaaac gtaatagatt taaagaagtt
    18241 tttagggaag cgagaaaacc attgattaag ggcagtttca atatctaatg ccttacggcc
    18301 gttgggttta atcgtgataa tgactttaga taatctttca actaaagtaa tgacggcact
    18361 tttatgatga atgccaacga tcgtatcacc ttcaaggtga ccaaactcag aattgaaatc
    18421 aggataatta tcagatcgat catggattga gcgctgatac tgttgttttc cccgtttttc
    18481 ctgatggcca ttgggttttc ttttacctct catcggtagt gtgtcaatat caaatattcc
    18541 tttagaaaat aaacgataaa gtgttctcat accgcatgaa acagaccttt cttttcgccc
    18601 gataatgacg tcaggcgtcc aaccaagagt gactttctct ttaatgtaat ctacttcatg
    18661 agcaggtaat tgaatgactt ttctaccaca ttttttctta ttttctttat actggtgcca
    18721 ataatcaaga gcagtcttgc cttgcttgaa cttattgact acattataaa tagtttgtat
    18781 agcacgtccc attcggttag cgatttcaac cggcttatta tgttgaagat aatatgattc
    18841 tatcattgtc agttcgtcta tggtaagatg tttgtaggtc atttatggtt acactccttt
    18901 gttttctttc gtcggaaata caatttgagt gtaccataaa tgccttttta tttttctaac
    18961 ttaattttac aattcgcgta gatataaatg taatggcata gtgcgggtgg ttctgttgca
    19021 aagttttaaa taaagaataa aatcccttac ggtatctatg atttaagctg ggattcccaa
    19081 taataccttg atttcagtac agaccgaaaa cccgaagaga gtgccttctt ttcgggtttt
    19141 cttatataat cctcgaatgg cttccatgcc tttaatcgtg gtagaggcag tgcgtaaact
    19201 tcgatagaat ttattgcgtc tctttactgg acgatggtct tgttcaatca aattattcag
    19261 gtatttaatg gtacgatgtt ctgttccttg ataaaagccg tattctttta gtttcttaaa
    19321 ggcacttgta atagaggggg ctttatctgt gactacaacc ttcggttcat caaactgctt
    19381 cactaaccgc ttaagaaaag cataggctgc ttgtgtgtcc cgttttttac gtaaccaaat
    19441 atccaaggtt aaaccatctg catcgatggc tcgatacaaa taatgccatt ttcctttaat
    19501 tttgatgtac gtttcatcca ttttccatga ataaaaggat tttttatttt tctttttcca
    19561 aatttgatag agtagtttgc catattcttg cacccaacga taaatcgtcg tatgagaaac
    19621 gttaatgcca cgatcatata agatttcttg aacttcacga tagctaaggt tataacgaag
    19681 atagtagccc acggctacaa taatcacatc ctgctgaaat tgctttcctt taaaaggatt
    19741 catcgtcatt cctcctgcta tctttttcta ttattctacc ttatttgata gtagatttaa
    19801 aactttgcaa cagaaccgtt cgtcacatct tcgatcaatt tctcttacga ttttctcatc
    19861 cacatttctt attcttactt ccatattaat tcctccaatt taaaaaggat agcgaaaagg
    19921 agcctatcct ttttgctatc ctactaccct ccttttacta tccttcacta tcctttcact
    19981 atcctatttt taaatatttt gttcccacat ttatttttga gaaacgtaat aggcacagcc
    20041 tattggaaca ctttttttaa aaagtgttcc cacgtttcct tatgctcttt acaaataaag
    20101 gcttttagag acgttctgga attttagatt ccttgaattg ttcccattca tcaatcaatt
    20161 ggctataagt agccattaat ttttttcttg ctcttgttgc tttcgaatca acaaaaaatc
    20221 agtttgattc gttaattcta aatattctgt tcggtattca atgttcatcg tacccgtttt
    20281 actacatagt aactgattat gacgttcttt cactttgaat aactgctcct tctttaaggt
    20341 ttttaactcc atgccaacta taagcacaat cctgtataga ggaatcattt tcaaacgatt
    20401 ctccataatt atttatcttt cattggaagt tctaaatcac tactgttcca aaaaatgtat
    20461 ggtttgtttt gacgaatatt acttccatct aaccacaatt ttccgatgcc atatcgtagg
    20521 cttgcttcga cttcataaaa attgtagatc tcttttcttc gatctattgc tttcatttcc
    20581 tggccatttt ttaaaataga tctgatgccc ttaacagtag attcatggat actcgtgtga
    20641 acgatatccg tattgatcaa ttcgtcatat cttccaaaat caacattgta ctcataacca
    20701 agaagtgtcg gaatcaggtc aatttcaatt tctttttcaa ttgaacgttt aataagtttc
    20761 gtggatacat acccgacaaa aaagagaata atacccactt caaacaaata catgtgtcca
    20821 tttacaaagt gaataaacgt caataaaaaa tccttcactc cttttgttgt tcttccagat
    20881 tgttcaattt gttttattaa agtcgctaga attgcattta caacaattaa atcgaatagg
    20941 cttttgaaaa gttttcctgc tgttaatttt tgcctggtaa attgcatgac taattgagta
    21001 aaaatagaca atagcatgac aaaaatcaac gtcattagca ctgtaaaaat gtctgatgct
    21061 gcaatcctat tgggatcatt tatcaagtaa taagccgttc caaatactcc aatcgagtaa
    21121 acggttaaat caagaataag tcgtgccccg taactacaaa gttttcctaa tggccataat
    21181 tgcaataccc aaaatttctt tcgtttgcta tttcttttca gaggaagcca ggtgtgttca
    21241 atccagtcgt ccgatttcat ttcgatttct tccctaaatt ctttccttta acgttttcct
    21301 ttgctacttt agcagcgata ggttgctcaa tgaaccaatt ttttaagtaa ataaaaacta
    21361 ctactggata tacttcttcc tttttcttaa ctcgttagct attttatact caatatactc
    21421 ctgctctaac acacacaaac aatcatatac ctgatccata gtctccccag aagctaagga
    21481 caacccatga agaaactcaa tcggcaaaga agcaactgtt ttttccctgg taacccaaga
    21541 agacaaagtc ccctgcttaa aaccataaag ctcacagaac acttccacag ataatcccaa
    21601 acgaccaatg ataaacacat taacaggatg tgaatagaca taatttttta acgacataca
    21661 acttcctcca tgatacataa gactgcatac gcagttataa gtataccacc tacacgtagc
    21721 taggcaaagg gagcaacacc tacagaagta tcatagatat attgtataag gcaatttgca
    21781 ccttttattt ttcaacctgt atctacttca aaaagattca cttctttaag agggttcaag
    21841 ggggttgata attgtctaaa tgtctcttct actaagctct cgttgagtcc aaatacctct
    21901 gtgatccttg ttgaataatc tagtctcttt tctttactta gttgaataac cctcgcgaac
    21961 aacgttttga ctgaagcaat gatcattccg ccatttcttc ctcgtgttac cttgtagaag
    22021 actttattct cctctcgtaa ctcatttaag atcttatcaa gtgttcgctt gggcatcgtt
    22081 agttgtgaag ccaattcttt ttttgacagg ttcaaataag gctcactagc aagacttttt
    22141 tcgcttagat aagccaatag atcttctttc cattcatttt tatgactata ttttctttga
    22201 tctcgtggct ttttaaattt ccaccagcca cgtcgttgaa tgaacagatc attatttttt
    22261 aaggttggtg aaacccattg ctggcacaat tcaataatga attctctgct tgctgcttga
    22321 taattaccag aataagcact acgtacaatc tttactaatt ctgcttcaga tagcggttcc
    22381 tgtaaccgtt cgttgaatgt gaacatattg tattcgcaag tatccaatgc ataacctgaa
    22441 gagtaataag ctaaagaaag cgtgaaaatc acattatttc gaccaagacg tccttctccg
    22501 ccgacgatgt ttgctttatg aagtaacata tcgaaccacg gttcatctac ttgacgaatt
    22561 tcttttttct caggaaagac aattagtttt cgttctcgat cttcttttgt tttttgatct
    22621 gattcaagct tcatcgacca ttgaatccag tcagcaaaag aatactgata gttcatttct
    22681 ttaaaaacaa tattattttc ttgtgggaat cgagcaattc cgaagtggtt acatcctaga
    22741 tccactccgg acaatttttc agccaactgt agacgaattg tttttgaaat tttttttgct
    22801 acatcgatca ccttgaaatt gcttttcttt gtgacatagc ctggtgtctt tagtacaaaa
    22861 taaacttgat aaccatgatc tgattctaaa attagcgttg gcatgtagcc cacttgatct
    22921 aaacaggcta aaataatttc gccttgatgg ttctcttttg aatcgatatc aactacaaat
    22981 gtgttgattt gacttaagtt tttctcagaa tgacctttaa ccactgttcg ataatcatcc
    23041 gcataagtac caaagcgata ggtattaggt gtccaatgcg ttagtttctt ttcgttctct
    23101 aaaatagctt cttccgaagt aatgaccata ccacgcccaa cattcattaa ttgcttgcta
    23161 cggtacgcaa agatagcacc actcctactg gaatcaatat gacctgcagg tttcatggtg
    23221 ctgtttcgat atttgtatgt acgtaagccg tttttaagaa tagctgaata aatttcgctc
    23281 aacatcgatt gtaacgtcct ttctcaaaca aaaagagaac acagtttagc tttaatctca
    23341 gccatagtat gtgttctctc ttcagtgttt aagaatattt aatttaagta cactaaataa
    23401 acgttcttct gttgagttgc tcgccttttt ttggtagaat aaaggcaatc ggaaaaggta
    23461 tccgatcaac ttttaatata agtagttggt agctacttac atattcttga gacgagcgtg
    23521 aacacatgtc ctaaccatgt gattcagaaa taattgattc tgctaaaatc aattatttcc
    23581 gtctcttttt tttatgtaat ttttctgttt aaagagtacc actgcttttg ctactttgta
    23641 aatagtgaat tatctgtggt ttctatagaa ttaagtttac ctcttttcac tctaaattgt
    23701 caacgcaaaa cgcacaaata tattttgaca ttttgaatat atctgatata ctgaatatag
    23761 caaatatatt tagtatatcc actatattcc ttataaagtc tgaattctta tcaatttgga
    23821 gtatattaga tatatcgaat atattaagta tatgaagtat actaaatata tttagtatag
    23881 gaaattggag ggaactatgg aaaacttacg gactgcattt aaaacatcag ataaactagg
    23941 aaaagttgta atgcttacag gtagaaaagg cggcattggt aagactacag acaatgattt
    24001 attagcgatt gtttctagtc aactttttga aaaagacgtg ttgctaattg attatgacca
    24061 acaaagaaat actacttcca acattggatc aacgtatcaa attactagct ttgatcgatc
    24121 catgtctgca gcaatcaaaa aaggggactg ggtttcaggt attactcaag taagtccaca
    24181 tttatatatt atggctggct ctcctggatc tgaagaactt aatgaatact tgtccgaaaa
    24241 atatcctgat cgtcgtaaga gatcattggc cttcattaaa cctttagaag aattgagaaa
    24301 aaatttcgat tatatcttta tcgactgccc accatcaaca gataatgtgg ttcgtgcatt
    24361 cttaactgct gcagattata ttattgcaat gcaagaatta aaacggtacg caatggaagg
    24421 aacagaagat tttattaata aagttttagt tccgattgtc acgaattttg aagagtctca
    24481 tcttcaaatc attggaattt tgcctgttct tttctcagtg cgacgttcct ctcaacacgc
    24541 aaactatcaa aaaacaattg ataagtatgg tgaatcaaac atttttaaaa gcattgttaa
    24601 aggctcggat cggttagaaa tgtatggtga gaatggtatc caattaaatg attatgtaga
    24661 tcgaagatgg tgggctattt ttgcagacat ctttacagaa ttagaagaaa gaattgaata
    24721 ctatgaacaa catggtgata ttgaaggatt tgattataca cctaaatatg ctgactcaat
    24781 ggccaatcat atcctacctc ttggaaagga gattaaacta aatggcatta ttaccaacga
    24841 acaaagataa gaagaaaatt ggtgctgaag atatttcaat taaagatgat attaatgtcg
    24901 agttagggga acgaaagtac actgcgaaag aaagaaaacc agttcaagta gatcctcccg
    24961 tactaaaaac cattcgggat cttagttatg caaaagatat tcctatgtat gaaatagtca
    25021 aacttgcaat ggacgcctat gttgatactt taaacgacga ggaacggatt atatataata
    25081 gacgatcaaa agattaaaat atagtaagta tactagatat agtaaatata tttagtatac
    25141 ttactatatt tttagcttta ttaatcctaa tccttcaaaa tatgtgtatt gtttgggggt
    25201 atacaacatt cacaaatttt attgtttcta gtttttacta tactaaatat atttaatata
    25261 gtgagtatag taaatatatt ggtttttatc tacaggtaat ggtggtttta acaaacatat
    25321 agttacagtt actgaagaac agtccgttag tcagcaggag taagtaataa atcgtttgtg
    25381 agacactatt ttgattgata cgacctctaa ccatgtgttt gtttcattta tgttataata
    25441 agaatgtaag catattaaac agcaaactat cacagcagca ctagactcaa tcaaatgaag
    25501 ggggatggtg ctaatgaaaa aactactagc aatttccctt atcctaaaaa ggagaattaa
    25561 tagtgtcaaa agaacctatg tccgcatgga tgcagctcgc tcttagcatc ataaagctga
    25621 tctctaattt tgtggcttta gacaatagag caaaggttct aactacgcaa tgtttagtaa
    25681 tacttacttg tagcctactg gttgtaatag tatttctttt acttgcgtta ttcgtagtac
    25741 accttttgtt tttttaaaac aaaagaagct tattcaacta tatttagctg aataagctgg
    25801 tctcaatgtt aaatcaagtt tgttggacgg gtttaacatt gctttctagt gctattttag
    25861 ttagctctag tatgcttcaa gctagttaca acgtcctaag gttgtaacta gtttttttat
    25921 attttttaat tacctatagg taattttatc agaattgata caaaatgtaa aacataaaag
    25981 aaatataatt ttattgcact ttaatagcca atatagtatt cgtatttatg gtatcctgct
    26041 gcagcttcta catagaaaga gaagcgttca acaccaacct catttatcaa acgctggcca
    26101 taaccccaaa tctcttctga tagctgatca aaggttatat actttagctc atattgctgg
    26161 ataatgttca ttctaatcga ccccatttat tatcctggta aaattcgata tgacgtattt
    26221 cgtcgtagtg aactttgttt tttccaacgt agatccccag ctcatcacta cctaagatct
    26281 tgctaacaat atcttctgga tagtatcctt cagcgtttcg ttcttctttt tgaatacata
    26341 ctgatctatt ttttatgact gcagcgttca atacttccgc aacctcttca gtcgtcattt
    26401 gttcttttgc caaattttga ttggctcgtt gttcattgtc ggcatcaatt ttttcagtat
    26461 gatcagataa ataaaaacct gcccacttta aacgtccacg atcattataa tcaatcattt
    26521 ttaagccctc ctgcgccgcc tgcatggcca ccaaccaatg tacttctagt aatactacga
    26581 gcgccttcta acatagaaga agcatgtaca atcgacgtaa aaccatattt ttgccgaatc
    26641 ttgtcaataa ttttatctaa attttcttcg tcaatttgct tttgtggatc actaaataaa
    26701 tccagctgaa gcgaatcagt gtacacaagc ttgctatagg ttattccaac gtgccttact
    26761 tcttgtcctt cataatactt atcaaacaag aaaagacagt aattctgcaa ttcctttgta
    26821 ttatctgtta tagggatctt catctggtgt gaaaaacctg gtctcgtttc taagatcgac
    26881 gtgccaatgt ataaatggac acaacctgtt ttacagttat gttgcctgat acgaatagct
    26941 acttgttccg ccatttcttt taccaccagt tcgatttcat ttctcctggt ataatctcgt
    27001 ggtaacactt gtgaattacc atatgatttt tcctttgtcg gttctggcgg gatcgctata
    27061 tctgttcgat cgatcccgtt cgcatgaaaa tacagctgta agccaatcac acctaaatgg
    27121 ctcttaatag tgtatggatt ccaattagct aagtctttaa tactcatgat accaatttgg
    27181 ttgagtcttt ttttcattcg agatccaata ccccaaaggt ctgtcatttc aggaatattc
    27241 catactttat caggaacatt ttgatacgtc cattcagcaa ggaatccatc attatgtttt
    27301 gcttcattgt ctaaagcaag tttagctaat aagggattat ctccgacacc tactgtagca
    27361 agcaatccta gctcttcttt aatattctcc tggatcattt gagccagctt ctttctccgt
    27421 tgacttcttg ttccttcagt cgtaaaaaga ttcattgatc tggtcacttt taagatcgat
    27481 tcatcgatcg agtaaatcaa taaatcttcg tctgctacat accttctgaa aatattgttt
    27541 acctgcatat ttcgcttaat atagagattc atgcgtggtg gaacgacatg taacgtttta
    27601 ggaaaaggtt gcggtagatc tcgtggtcga ctgacattag aaataccgta cttcttcttt
    27661 gcagctggtg aagaagctaa aatcaaccct gatcctgtat tatccgctcg actcatgacg
    27721 actaattcag tcgttaatgg atctaaattc ctttctatac attcgacact tgcgtaaaag
    27781 cttttcatat cgatcaaaaa gtaatcattt actggctctt ttgaataatc catcataaat
    27841 aacactccat tcttccacat tatacaaaca tacgttcgtt tttgtaaaga agaatcgatt
    27901 aaatgtacaa aaaaagaagc ataggtaagt tatttcccta cttcttctgt tgatttgtaa
    27961 aatcaacaca ttgtatcact ttattaaatg gatatttact attagtcttg tgaaaatttg
    28021 aaaataagtg tcgtattatc cagttttgct tagttatatt agaaaaaaat aagaaattca
    28081 aaaaagaaaa aactttcctt aaaaacaaaa aataggagta ttcagtttct taatagtttt
    28141 gtaatagttg tatgtagaag ttttcttaat agtttttgta ataatttatt aatcgtagtt
    28201 tatataactt atttgtaagt gactagagaa ttaaataaaa aataattact atctagtacg
    28261 aaattaatta cataggataa tatattaagg tgctggacta caagtaaaaa atactgtatg
    28321 atcatgacag attcaagaaa ggagcaataa gattggttaa gatagcagga ctttctaaag
    28381 gtggaaaaac cgtttcacaa ctttataaac aaaactacag agactggaga cagttcagaa
    28441 aaaacattaa ggattcttac tttattctac caacagaact tgaaaaatat ttaccgaata
    28501 acaaagctat taatttatat ctgtattact gttttaaggc aaagaatgaa ggcgggga
//
