LOCUS       CP063558               27475 bp    DNA     circular BCT 04-APR-2022
DEFINITION  Enterococcus faecium strain BMT-1-1-10 plasmid pIN-1-10_03, complete
            sequence.
ACCESSION   CP063558
VERSION     CP063558.1
DBLINK      BioProject: PRJNA669626
            BioSample: SAMN16483164
KEYWORDS    .
SOURCE      Enterococcus faecium
  ORGANISM  Enterococcus faecium
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 27475)
  AUTHORS   Both,A., Kruse,F., Mirwald,N., Franke,G., Christner,M., Huang,J.,
            Hansen,J.L., Kroger,N., Berneking,L., Lellek,H., Aepfelbacher,M. and
            Rohde,H.
  TITLE     Population dynamics in colonizing vancomycin-resistant Enterococcus
            faecium isolated from immunosuppressed patients
  JOURNAL   J Glob Antimicrob Resist 28, 267-273 (2022)
   PUBMED   35134550
REFERENCE   2  (bases 1 to 27475)
  AUTHORS   Both,A., Kruse,F., Christner,M., Huang,J., Mirwald,N., Franke,G. and
            Rohde,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-OCT-2020) Institute of Medical Microbiology, Virology
            and Hygiene, University Medical Center Hamburg-Eppendorf,
            Martinistr. 52, Hamburg, Hamburg 20246, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Trycycler v. v0.3.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 510.0x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 10/27/2020 16:36:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.13
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 3,265
            CDSs (total)                      :: 3,174
            Genes (coding)                    :: 3,071
            CDSs (with protein)               :: 3,071
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 32 of 103
            Pseudo Genes (incomplete)         :: 65 of 103
            Pseudo Genes (internal stop)      :: 16 of 103
            Pseudo Genes (multiple problems)  :: 9 of 103
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..27475
                     /organism="Enterococcus faecium"
                     /mol_type="genomic DNA"
                     /strain="BMT-1-1-10"
                     /isolation_source="rectal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1352"
                     /plasmid="pIN-1-10_03"
                     /geo_loc_name="Germany: Hamburg"
                     /lat_lon="53.33 N 10.1 E"
                     /collection_date="2014-07-08"
                     /collected_by="Institute of Medical Microbiology, Virology
                     and Hygiene, University Medical Center Hamburg-Eppendorf"
     gene            1..1086
                     /locus_tag="IQN16_15900"
     CDS             1..1086
                     /locus_tag="IQN16_15900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002352763.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="UOC33551.1"
                     /translation="MSTEIQSQKMIIKNWGYKATNVYIEKYYKFPSFLIQNSKYSKMKD
                     SSKIAYMLFKNEFRRALHEKWIDDDGLLYLEFTQADLMDKLNCYQGKVKTILNELETYN
                     LISVVKGEFNPKTKKNEKNKYYLLQPEISADDLFIQNSFDDDLSQTIDKSTSSRNAEIA
                     RREETAKTLDNTGNAEIARREKTAETLDNTGNAEIAQDYYINKSLDTKRHLKDTETDQL
                     QNQVLLDNFVEIMKEDSINTFVPEKVLSLIKTFSNTYEEAQQTVTTIHNAKHKAEELEK
                     TVVVYEELESYGIDADKGLYMTLLKAYQKQKTEKVNNLQNLIFVYVKNWFIEKAIAAKL
                     ANEQRETFNELPTVSTENWLE"
                     /name="replication initiator protein A"
     gene            complement(1879..3174)
                     /locus_tag="IQN16_15905"
     CDS             complement(1879..3174)
                     /locus_tag="IQN16_15905"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002297185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3-like element ISEfa5 family transposase"
                     /protein_id="UOC33552.1"
                     /translation="MNDSIKKMLRLIEKDLMITEVSYETFQKKKTLIVDAVFSPAPHTC
                     RNCGSTVVDGNGKVIVVKNGKKETIVRFEQYNHMPLVMRLKKQRYTCKNCRTHWTAQSY
                     FVQPRHSIANHVRYKIASLLTEKVSLSFIAKNCQVSLTTVIRTLKEFKSYLPKQSKRIL
                     PRVLMVDEFRSHASIEDKMSFICADGETGQLIDVLPTRKLPRLTSYFLGCANPEEVKFL
                     VTDMNAAYFQLTKRILPNAKVVIDRFHIIKHMNQAFNELRIREMNELRKVGQKSQAEKL
                     KKNWRFLLKNRANINHYEYKTWKSFRAPKYPFLTEAMMIDRLLGFSTSLKEAYPYFHEL
                     VEAFRDKDPDLFFSLLAELPETLDDGFREKLQNLLTYEEGITNAMIYPYTNGKIEAKNT
                     HIKTMKRVSYGFKSFENMRIRIFLINQLIKVR"
                     /name="ISL3-like element ISEfa5 family transposase"
     gene            3445..3777
                     /locus_tag="IQN16_15910"
     CDS             3445..3777
                     /locus_tag="IQN16_15910"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002310954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein TraE"
                     /protein_id="UOC33553.1"
                     /translation="MSYTGILSLEDICHYGKRCTATEKITKKLSTGQNKTVVQCKKYII
                     QKDKVSEEMIYYVGKQKQIILKDPIPLKELYPTIKHVYDQNGVLIGRRKNGVLRCTAKG
                     MGRLIS"
                     /name="conjugal transfer protein TraE"
     gene            complement(4121..4195)
                     /locus_tag="IQN16_15915"
                     /pseudo=""
     CDS             complement(4121..4195)
                     /locus_tag="IQN16_15915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002339851.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /name="IS6 family transposase"
     gene            4328..5623
                     /locus_tag="IQN16_15920"
     CDS             4328..5623
                     /locus_tag="IQN16_15920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3-like element ISEfa11 family transposase"
                     /protein_id="UOC33554.1"
                     /translation="MNDSIKKMLRITEKDLMITEVSYETLQKKKTLVVDAVLSPTPRAC
                     RSCGSTVVDGNGKAIIVKNGKKETIVRFEQYNHMPLVMRLKKQRYTCKNCRTHWTAQSY
                     FVQPRHSIANHVRYKIASLLTEKVSLSFIAKSCQVSLTTVIRTLKEFKSYLPKQSKKIL
                     PRVLMVDEFRSHASIEDKMSFICADGETGKLIDVLPTRKLPRLTSYFLGCTNPEEVEFL
                     VTDMNAAYFQLTKRVLPNAKVVIDRFHIVKHMNQAFNELRIREMNELRKAGQKSQAEKL
                     KKNWRFLLKNRANINHYEYKTWKSFRAPKYPFLTEAMMIDRLLEFSPPLKEAYPFFHEL
                     VEAFRDKDPDLFFSLLAELPETLDDSFREKLQNLLTYEEGITNAMIYPYSNGKIEAKNT
                     HIKTMKRVSYGFKSFENMRIRIFLINQLINVR"
                     /name="ISL3-like element ISEfa11 family transposase"
     gene            complement(5649..6323)
                     /locus_tag="IQN16_15925"
     CDS             complement(5649..6323)
                     /locus_tag="IQN16_15925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="UOC33555.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGSLSIRTDELCKIKSE
                     SE"
                     /name="IS6 family transposase"
     gene            complement(6399..6545)
                     /locus_tag="IQN16_15930"
                     /pseudo=""
     CDS             complement(6399..6545)
                     /locus_tag="IQN16_15930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010625604.1"
                     /note="incomplete; partial on complete genome; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /name="replication initiation protein"
     gene            7182..7268
                     /locus_tag="IQN16_15935"
     CDS             7182..7268
                     /locus_tag="IQN16_15935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017548328.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="UOC33566.1"
                     /translation="MFELFICPLLIEVCVSLFSYWLNNRNKK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(7389..8078)
                     /locus_tag="IQN16_15940"
     CDS             complement(7389..8078)
                     /locus_tag="IQN16_15940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002298772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC33556.1"
                     /translation="MAFYLPYLLIFASILGIIWLSYKAYQTRYSLKGSKIRFKRFLLPG
                     VIFTLSIVLSGLFGVLEGNKRISRSILLGDITQKYEAACDKKKKEQVLTQKMEEFTTCY
                     EEMNDIFVNQEKRLTDKNMEKLTRLYQNLPEKQQKEVQDNYERTKKDVQYFKDTQTEEA
                     CYNLFSDTIPFSTSEQERKERQQSVTYERYKALLQQATNIQNPTKKETALNYLKSVKEW
                     LDQQQQN"
                     /name="hypothetical protein"
     gene            complement(8085..8363)
                     /locus_tag="IQN16_15945"
     CDS             complement(8085..8363)
                     /locus_tag="IQN16_15945"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002354385.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC33557.1"
                     /translation="MKEEQTTNKNYRSKTLQDIENEIKKQRAFLAPYTKERIQTTIDSQ
                     VKKFHHALLNQRNKEQKKVIMQRSMDILAPLCCLIMTLLAFWLVWGE"
                     /name="hypothetical protein"
     gene            complement(8323..9237)
                     /locus_tag="IQN16_15950"
     CDS             complement(8323..9237)
                     /locus_tag="IQN16_15950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002340563.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="relaxase/mobilization nuclease domain-containing
                     protein"
                     /protein_id="UOC33558.1"
                     /translation="MATVKVSRTTSCSRAINYAEPRATVKTGINCDIDYAKSEMKQIRM
                     LYGKDDRVQAHLLIQSFRPGEITAEKANQLGAEYAKKIAPDHQIAIYTHTDKDHIHNHI
                     VINSVNLETGNKFQAHGQAFLNKCYDLNDEICLEHDLTITERGKKPEKRTMSEIKLKEK
                     NEPVWKDEIRFAIDQTMKNKKTRTYNQFCDSLKTFGIHCLNRGKNFTYELIHKKKKVRS
                     NKLGKDYEKETILHELDRRERAYNQQRTNELRRARASIRETAKEVRREQRTLTTEQPEI
                     RPTRRNHDQHVERGADYQQELSF"
                     /name="relaxase/mobilization nuclease domain-containing
                     protein"
     gene            complement(9219..9599)
                     /locus_tag="IQN16_15955"
     CDS             complement(9219..9599)
                     /locus_tag="IQN16_15955"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002348702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family plasmid mobilization relaxosome
                     protein"
                     /protein_id="UOC33559.1"
                     /translation="MSEQNQYLASNHSKKYTYRSEPKQISFRVSESEFAKLKQSAEALQ
                     MSVPAFVKAKAQNARLVTPKVAPDIAQAIARDLAKAGGNINQIAKWCNTHQHDVDPGDA
                     QRLSENLKIMQKELQKIWQQLK"
                     /name="MobC family plasmid mobilization relaxosome protein"
     gene            complement(10050..10337)
                     /locus_tag="IQN16_15960"
     CDS             complement(10050..10337)
                     /locus_tag="IQN16_15960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002363589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin immunity protein"
                     /protein_id="UOC33560.1"
                     /translation="MDFTKEEKLLNAISKVYNEATIDDYPDLKEKLFLYSKEISEGKSV
                     GEVSMKLSSFLGRYILKHKFGLPKSLIELQEIVSKESQVYRGWASIGIWS"
                     /name="bacteriocin immunity protein"
     gene            complement(10357..10581)
                     /locus_tag="IQN16_15965"
     CDS             complement(10357..10581)
                     /locus_tag="IQN16_15965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002363584.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin hiracin-JM79"
                     /protein_id="UOC33561.1"
                     /translation="MKKKVLKHCVILGILGTCLAGIGTGIKVDAATYYGNGLYCNKEKC
                     WVDWNQAKGEIGKIIVNGWVNHGPWAPRR"
                     /name="bacteriocin hiracin-JM79"
     gene            complement(11036..11206)
                     /locus_tag="IQN16_15970"
     CDS             complement(11036..11206)
                     /locus_tag="IQN16_15970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002322958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC33562.1"
                     /translation="MTKKHLLFGSILLGILSFSPMLLSVANKGNKKGELKLNPNYYNSQ
                     NEEVFVEKLDK"
                     /name="hypothetical protein"
     gene            complement(11221..11754)
                     /locus_tag="IQN16_15975"
     CDS             complement(11221..11754)
                     /locus_tag="IQN16_15975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002292473.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="UOC33563.1"
                     /translation="MQPQETFTIKELSDLFKMSRQAISKHIQKLDSSMIAKNERGYKVV
                     LRSGVLQLARNLDNQRLLDKLHKHEQNNDKNAYIPNKNVVANKLLDQLREENEFLREQL
                     ALKEQNNSHIQKLLDQQQQLTLQANQQIEKLQEQLQLTYTEESSENSSTTLSEATETMD
                     EQTKNWKKWWQLWK"
                     /name="DUF536 domain-containing protein"
     gene            complement(11775..12221)
                     /locus_tag="IQN16_15980"
                     /pseudo=""
     CDS             complement(11775..12221)
                     /locus_tag="IQN16_15980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002303559.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="initiator RepB protein"
                     /name="initiator RepB protein"
     gene            complement(12277..12957)
                     /locus_tag="IQN16_15985"
     CDS             complement(12277..12957)
                     /locus_tag="IQN16_15985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="UOC33564.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            13246..13941
                     /gene="vanR"
                     /locus_tag="IQN16_15990"
     CDS             13246..13941
                     /gene="vanR"
                     /locus_tag="IQN16_15990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001280781.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanA-type vancomycin resistance DNA-binding
                     response regulator VanR"
                     /protein_id="UOC33565.1"
                     /translation="MSDKILIVDDEHEIADLVELYLKNENYTVFKYYTAKEALECIDKS
                     EIDLAILDIMLPGTSGLTICQKIRDKHTYPIIMLTGKDTEVDKITGLTIGADDYITKPF
                     RPLELIARVKAQLRRYKKFSGVKEQNENVIVHSGLVINVNTHECYLNEKQLSLTPTEFS
                     ILRILCENKGNVVSSELLFHEIWGDEYFSKSNNTITVHIRHLREKMNDTIDNPKYIKTV
                     WGVGYKIEK"
                     /name="vanR"
     gene            13919..15073
                     /locus_tag="IQN16_15995"
     CDS             13919..15073
                     /locus_tag="IQN16_15995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002305818.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanA-type vancomycin resistance histidine kinase
                     VanS"
                     /protein_id="UOC33536.1"
                     /translation="MVIKLKNKKNDYSKLERKLYMYIVAIVVVAIVFVLYIRSMIRGKL
                     GDWILSILENKYDLNHLDAMKLYQYSIRNNIDIFIYVAIVISILILCRVMLSKFAKYFD
                     EINTGIDVLIQNEDKQIELSAEMDVMEQKLNTLKRTLEKREQDAKLAEQRKNDVVMYLA
                     HDIKTPLTSIIGYLSLLDEAPDMPVDQKAKYVHITLDKAYRLEQLIDEFFEITRYNLQT
                     ITLTKTHIDLYYMLVQMTDEFYPQLSAHGKQAVIHAPEDLTVSGDPDKLARVFNNILKN
                     AAAYSEDNSIIDITAGLSGDVVSIEFKNTGSIPKDKLAAIFEKFYRLDNARSSDTGGAG
                     LGLAIAKEIIVQHGGQIYAESNDNYTTFRVELPAMPDLVDKRRS"
                     /name="VanA-type vancomycin resistance histidine kinase
                     VanS"
     gene            15288..16256
                     /locus_tag="IQN16_16000"
     CDS             15288..16256
                     /locus_tag="IQN16_16000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001059542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-lactate dehydrogenase VanH-A"
                     /protein_id="UOC33537.1"
                     /translation="MNNIGITVYGCEQDEADAFHALSPRFGVMATIINANVSESNAKSA
                     PFNQCISVGHKSEISASILLALKRAGVKYISTRSIGCNHIDTTAAKRMGITVDNVAYSP
                     DSVADYTMMLILMAVRNVKSIVRSVEKHDFRLDSDRGKVLSDMTVGVVGTGQIGKAVIE
                     RLRGFGCKVLAYSRSRSIEVNYVPFDELLQNSDIVTLHVPLNTDTHYIISHEQIQRMKQ
                     GAFLINTGRGPLVDTYELVKALENGKLGGAALDVLEGEEEFFYSDCTQKPIDNQFLLKL
                     QRMPNVIITPHTAYYTEQALRDTVEKTIKNCLDFERRQEHE"
                     /name="D-lactate dehydrogenase VanH-A"
     ARG             16232..17280
                     /name="vanA"
                     /gene="vanA"
                     /gene_name="glycopeptide resistance gene cluster; Van
                     ligase"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="99.71"
                     /coverage="101.75"
     ARG             16250..17277
                     /name="vanA"
                     /gene="vanA"
                     /gene_name="D-alanine--(R)-lactate ligase VanA"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="99.71"
                     /coverage="100.0"
     gene            17286..17894
                     /locus_tag="IQN16_16010"
     CDS             17286..17894
                     /locus_tag="IQN16_16010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000402347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-Ala-D-Ala dipeptidase VanX-A"
                     /protein_id="UOC33539.1"
                     /translation="MEIGFTFLDEIVHGVRWDAKYATWDNFTGKPVDGYEVNRIVGTYE
                     LAESLLKAKELAATQGYGLLLWDGYRPKRAVNCFMQWAAQPENNLTKESYYPNIDRTEM
                     ISKGYVASKSSHSRGSAIDLTLYRLDTGELVPMGSRFDFMDERSHHAANGISCNEAQNR
                     RRLRSIMENSGFEAYSLEWWHYVLRDEPYPNSYFDFPVK"
                     /name="D-Ala-D-Ala dipeptidase VanX-A"
     gene            18300..19232
                     /gene="vanY"
                     /locus_tag="IQN16_16015"
     CDS             18300..19232
                     /gene="vanY"
                     /locus_tag="IQN16_16015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanY-A/VanY-F/VanY-M family D-Ala-D-Ala
                     carboxypeptidase"
                     /protein_id="UOC33567.1"
                     /translation="MVKEETENEEVVFLLLLLFLIYLGYDYVNEALFSQEKVEFQNYDQ
                     NPKEHLENSGTSENTQEKTITEEQVYQGNLLLINSKYPVRQESVKSDIVNLSKHDELIN
                     GYGLLDSNIYMSKEIAQKFSEMVNDAVKGGVSHFIINSGYRDFDEQSVLYQEMGAEYAL
                     PAGYSEHNSGLSLDVGSSLTKMERAPEGKWIEENAWKYGFILRYPEDKTELTGIQYEPW
                     HIRYVGLPHSAIMKEKNFVLEEYMDYLKEEKTISVSVNGEKYEIFYYPVTKNTTIHVPT
                     NLRYEISGNNIDGVIVTVFPGSTHTNSRR"
                     /name="vanY"
     gene            19385..19597
                     /locus_tag="IQN16_16020"
                     /pseudo=""
     CDS             19385..19597
                     /locus_tag="IQN16_16020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000516404.1"
                     /note="incomplete; partial on complete genome; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            19674..20354
                     /locus_tag="IQN16_16025"
     CDS             19674..20354
                     /locus_tag="IQN16_16025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="UOC33540.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            20837..21658
                     /locus_tag="IQN16_16030"
     CDS             20837..21658
                     /locus_tag="IQN16_16030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812603.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
                     /protein_id="UOC33541.1"
                     /translation="MYQFLKTGATILNYYQQYKENKKRCGRRSIALPEEQKEYVQKRVV
                     QGWTPDVIVGRSEMKLDCSVRTLYRMFQTGAFNVRDLPMKGKRKPNGHQEKRGKQAFRR
                     SIHERIKEHPEFENEFGHLEGDTIVGRKHKSAVITLVERLSKVIITLKPAGRQAMDIEN
                     RINHWFQTVPKHLFKSITFDCGKEFSNWKAMGNQNDIDIYFADPGTPSQRALNEHSNGL
                     LRRDGLVKAMDFNEVSESFIEYRKHFLYSILSSFKFSIDYIYCEFCRGSET"
                     /name="IS30 family transposase"
     gene            21745..22350
                     /locus_tag="IQN16_16035"
     CDS             21745..22350
                     /locus_tag="IQN16_16035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016176895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fic family protein"
                     /protein_id="UOC33542.1"
                     /translation="MILENKLGLTNQVELAKAEEKLSKQKAKELYDSGKINEIEVGTFK
                     GLSEIHDFLFSEIYDFAGKIRTVNIAKGNFRFAPVMYLEQSLNHIDQMPQTSFEEIIKK
                     YVEMNIAHPFREGNGRSTRIWLDLILKEELQKVVDWNLIDKADYLSAMERSPINDLEIR
                     YLISNALTDKIDDRELYMKGIDVSYFYEGYSEYTIDDL"
                     /name="Fic family protein"
     gene            22366..22941
                     /locus_tag="IQN16_16040"
     CDS             22366..22941
                     /locus_tag="IQN16_16040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002300096.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="UOC33543.1"
                     /translation="MTKYGYARVSTASQSTKEQIQQLLENGVEKKNIFSEKFTGTKRDR
                     PKFNQLLAGLKPGDEIVVTKLDRFARNTREALEIIEPLLDDNVTIKVLNLGTIENTSMG
                     RMVTRTLLSVAEMDRDMIVERTQEGKLFAKKNNPNFKEGRPKATITPKKRHAYELITSG
                     KSYKEVEAITGFSRSTLFRIKKQIEASE"
                     /name="recombinase family protein"
     gene            23101..23304
                     /locus_tag="IQN16_16045"
     CDS             23101..23304
                     /locus_tag="IQN16_16045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002300097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA helicase UvrA"
                     /protein_id="UOC33544.1"
                     /translation="MKEQQLGYTLWGRPLYGLERRTAVSIDCACGELIQLNIQTKQYNC
                     KNCGNCYQFIDQDFQLLNEKNK"
                     /name="DNA helicase UvrA"
     gene            23413..24738
                     /locus_tag="IQN16_16050"
     CDS             23413..24738
                     /locus_tag="IQN16_16050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002335330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Y-family DNA polymerase"
                     /protein_id="UOC33545.1"
                     /translation="MLDYSKEPVNDYFLIDMKSFYASVECIERNLDPLTTELVVMSRAD
                     NTGSGLILASSPAAKKKYGISNVSRPRDLPQPFPKTLHVVPPRMNLYIKRNMQVNNIFR
                     RYVADEDLLIYSIDESILKVTRSLNLFTTEGTRSQRRKNLAQMIQERIKEELGLIATVG
                     VGDNPLLAKLALDNEAKHNEGFIAEWTYENVPEKVWNIPEMTDFWGIGSRMKKRLNQMG
                     ILSIRDLANWNPYTIKNRLGVIGLQLYFHANGIDRTDIAIPPEPTKEKSYGNSQVLPRD
                     YTRRNEIELVVKEMAEQVAIRIRQHNCKTGCVHLNIGTSILETRPGFSHQMKIPITDNT
                     KELQNYCLFLFDKYYEGQEVRHVGITYSKLVYTDSLQLDLFSNPQKQIDDEKLDKIIDK
                     IRQKYGFTSIVHASSMLEGARSITRSTLVGGHAGGAGELKND"
                     /name="Y-family DNA polymerase"
     gene            24731..25081
                     /locus_tag="IQN16_16055"
     CDS             24731..25081
                     /locus_tag="IQN16_16055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002359653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC33546.1"
                     /translation="MIDYNDRGRLKWVGFYLSDHTEEIDADNEQRANNNLAKEQMTTEE
                     ISEVLNAAVIKNRSVCIQKEERNAEGYYPDDIVGKILGSDELGIYVGKYKIHYDEIRHI
                     EFYQDNKWSRLE"
                     /name="hypothetical protein"
     gene            25078..25257
                     /locus_tag="IQN16_16060"
     CDS             25078..25257
                     /locus_tag="IQN16_16060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001021554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC33547.1"
                     /translation="MNIIQQYELKYITFDQLSEEIWGYGQRLINEVGVERFSFYVEVAA
                     GYHNFRFYIFPLFI"
                     /name="hypothetical protein"
     gene            25393..25686
                     /locus_tag="IQN16_16065"
     CDS             25393..25686
                     /locus_tag="IQN16_16065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002352765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type III secretion system protein PrgN"
                     /protein_id="UOC33548.1"
                     /translation="MSINTFVYSHPINVYIIKNLGITVEQFCELYAYPQGTVASWITRQ
                     RRIKSLPASFVYDLSLASSMNMTDVYEKLLILENEYDQFTSNQQRKVKKQID"
                     /name="type III secretion system protein PrgN"
     gene            25912..26730
                     /locus_tag="IQN16_16070"
     CDS             25912..26730
                     /locus_tag="IQN16_16070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002305212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family protein"
                     /protein_id="UOC33549.1"
                     /translation="MDTFQGTTFTVGNFKGGVGKTKIVSMLAYDNAMIRNRKTLIIDLD
                     PQANLTQVIARTFGITDIKTTITNGVANGELASSIIKVNENLDLLACDTSFRSFSAFAN
                     KHENELDQVTVLKKLLLPIKNNYQEIFIDVPPTISEFSDNAMAASDYSIISFQTAEESL
                     EGVNKYVNYQKFMVDRYDLDLQIIDIVPCMVEPNDDFDEEILEEAIEKYGTVVSKNLIH
                     YQKRLRRYSKIGIHLRKYKNGNFDQWDYKAHQVFINILAELDARQEFLNK"
                     /name="ParA family protein"
     gene            26749..27156
                     /locus_tag="IQN16_16075"
     CDS             26749..27156
                     /locus_tag="IQN16_16075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002305214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UOC33550.1"
                     /translation="MPKDFDIPKMMENGEFEPLLPNNKRQDVKISGEYNFSNSALSNTK
                     NITLKKRGRPVSIPDKRNKVSVPKKISPALNSKLSILQDYMTELQSEKGRISFEKIVNT
                     LADSYIQHRLGVAKEEHIREEIQEEFEKLPK"
                     /name="hypothetical protein"
     ARG             15289..16253
                     /name="vanH-A"
                     /gene="vanH-A"
                     /gene_name="D-lactate dehydrogenase VanH-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             13920..15070
                     /name="vanS-A"
                     /gene="vanS-A"
                     /gene_name="vancomycin resistance histidine kinase VanS-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             13247..13938
                     /name="vanR-A"
                     /gene="vanR-A"
                     /gene_name="vancomycin resistance response regulator
                     transcription factor VanR-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             18325..19229
                     /name="vanY-A"
                     /gene="vanY-A"
                     /gene_name="D-Ala-D-Ala carboxypeptidase VanY-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="98.68"
                     /coverage="99.67"
     ARG             17287..17891
                     /name="vanX-A"
                     /gene="vanX-A"
                     /gene_name="D-Ala-D-Ala dipeptidase VanX-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             15289..16256
                     /name="vanH gene in vanA cluster"
                     /gene="vanH gene in vanA cluster"
                     /gene_name="vanH; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             13247..13941
                     /name="vanR gene in vanA cluster"
                     /gene="vanR gene in vanA cluster"
                     /gene_name="glycopeptide resistance gene cluster; vanR"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             18253..19232
                     /name="vanY gene in vanA cluster"
                     /gene="vanY gene in vanA cluster"
                     /gene_name="vanY; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="98.68"
                     /coverage="107.59"
     ARG             13920..15074
                     /name="vanS gene in vanA cluster"
                     /gene="vanS gene in vanA cluster"
                     /gene_name="vanS; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="100.0"
                     /coverage="94.79"
     ARG             17287..17894
                     /name="vanX gene in vanA cluster"
                     /gene="vanX gene in vanA cluster"
                     /gene_name="vanX; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     BGC             5357..15581
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          680..1086
                     /name="rep_cluster_889"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(8327..9237)
                     /name="MOBP"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="93.421"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 atgtctacag aaattcaatc tcaaaaaatg attattaaaa attggggata taaagcaacg
       61 aatgtttata ttgaaaaata ttataaattt cctagttttt taattcagaa ttctaaatac
      121 tctaaaatga aagacagctc aaaaatagcc tatatgcttt ttaaaaatga atttcgtaga
      181 gccttacatg aaaaatggat cgacgatgat ggtctattat atttggaatt tacacaagca
      241 gacctaatgg acaaattaaa ttgctaccaa ggcaaagtaa aaaccatttt aaacgagtta
      301 gaaacatata atttgatttc agtcgtaaaa ggagaattta acccaaaaac gaaaaaaaat
      361 gaaaaaaata aatactattt acttcaacct gaaataagtg ccgatgatct ttttattcag
      421 aattctttcg atgacgattt aagccaaact attgataaat caacctcttc tcggaatgcg
      481 gaaatcgcac gtcgagagga aactgctaaa acccttgata atactggaaa tgcggaaatc
      541 gcacgtcgag aaaaaacagc tgaaaccctt gataacactg gaaatgcgga aatcgcacaa
      601 gattattata ttaataaatc tttagacact aaaagacact taaaagacac tgaaacagac
      661 caattacaaa atcaagtttt gctagataac ttcgttgaaa tcatgaaaga agacagcata
      721 aacacatttg taccagaaaa ggtattaagc ttgataaaaa cattttctaa cacttacgaa
      781 gaagcccaac aaaccgtcac cacaatacac aacgcaaaac ataaagccga ggaacttgag
      841 aagacggtag ttgtgtatga agaacttgaa tcttacggaa ttgatgcgga taaaggatta
      901 tatatgacgt tgctgaaagc ttatcaaaaa caaaagactg agaaagtaaa taatttgcag
      961 aatttgattt ttgtgtatgt aaaaaactgg tttattgaaa aagctattgc ggcaaagctt
     1021 gcaaacgaac aaagagaaac atttaacgaa ttaccaacag ttagtacgga aaattggcta
     1081 gagtagttga taaaaagcga tcactataaa aatgatcaat tttaaattag aactttttta
     1141 taattttaat tttattacaa atgttacaaa taaatagtta ttattccgga gtttttagat
     1201 taaaagttta tgaaaacaat cacaaacgta ggttttaatg tcataatcgt tagatatttt
     1261 agttattttt cattcaaaaa aaatagggaa ctagtgtttg catatgtgct tttttgagtt
     1321 ataataattc atgaagagag gtaattcact tatttcccca agctgaaaag cctgatatta
     1381 cttcttttca ggcagtgctg ctaatattca attacacttt tttgtatatt tttagttgtt
     1441 ttaaatttaa ttgtctgcta tgcttgtgat gaattgattt tcgttctgca cttttggacg
     1501 ataaatttgg acaattgaaa atacaaaaaa aagaaaggcc cctgtaagac tcgggagact
     1561 ggtaatctcc gtcagtgccc tacaggaaag cattaagctc actccttaat gcgtgccctt
     1621 cagtgttacg gtattacccg caacggattt agtataacag atattcaaaa gtgataccac
     1681 tttttttggc tgtgttaagg ttaaaaatac gtgatattac gatgaatcta tgcctaagca
     1741 taatgttata aaaatgtccg tgtggctctt tgccgtatga tgaacgctga aattagggct
     1801 ctttgtcaat aaggactgat gggttgtaca aaatcaaatc tgggtcagaa tgaacctcat
     1861 tctggctcag attttttgtt atcttacttt gattaattga ttgatcaaaa agattctaat
     1921 tctcatgttc tcaaatgatt taaatccgta ggatactcgt ttcattgtct ttatatgggt
     1981 attcttcgct tctatttttc cattggtgta aggatagatc atcgcgttgg tgatgccttc
     2041 ttcataggtc agaaggtttt ggagcttttc ccgaaagccg tcatctaacg tttcgggaag
     2101 ttctgccaat aaggagaaaa ataagtcagg gtctttgtct cgaaaggctt caactaattc
     2161 atgaaaatag ggatacgcct ccttcaggga cgtagaaaag ccaagcaatc gatcaatcat
     2221 catcgcttcc gtaagaaatg ggtattttgg tgctcgaaaa cttttccatg ttttgtattc
     2281 ataatggttg atgtttgcac gattttttag caaaaagcgc cagttctttt tcagtttttc
     2341 tgcctgactt ttctgtccta ctttacgaag ttcattcatt tcacggatac gcaactcatt
     2401 aaaggcttga ttcatgtgtt tgataatatg aaaccgatca atcactactt tcgcatttgg
     2461 cagaatacgt ttggtaagct ggaagtaggc ggcgttcatg tctgtgacta aaaattttac
     2521 ttcttcagga ttagcgcagc ctaagaaata gcttgttaat cgaggcaatt tacgcgtagg
     2581 caagacatca attaattgtc ctgtttcgcc atctgcgcaa ataaagctca ttttatcttc
     2641 tatggaagcg tgcgaacgaa attcatcaac catcaatact ctggggagaa tcctcttaga
     2701 ttgctttggt aagtagcttt taaactcttt caacgtacga ataacggtgg tcaaagatac
     2761 ctgacaattt ttcgcaataa aagataaaga tactttttca gtcagtaaag aagcaatttt
     2821 atatctgaca tgattcgcga ttgaatgtct gggttgaaca aaataacttt gagccgtcca
     2881 atgggttcga cagtttttac aggtatagcg ctgctttttt aagcgcataa ccaaaggcat
     2941 gtgattgtat tgttcaaagc ggacaatcgt ttccttcttc ccatttttca ctacaattac
     3001 tttcccgttt ccatctacca cagtagaacc acaatttcta caggtatggg gagcaggtga
     3061 gaaaacagca tcgacgatca acgtcttttt cttctgaaag gtctcgtaag agacctctgt
     3121 aatcatcaaa tctttctcta ttaatcgcag catttttttg atagaatcat tcatatagca
     3181 tatcgtcctc tcagttgttt attttgtcgt gatttaatca tactagagaa cgatatgttt
     3241 tttaatacct aaaataaaaa tggggctgaa gaatcaattc tgattcatca gtcccataaa
     3301 ttatagagcc gaaattagag ggaacgcatg tttggatgcg ttccctcttt tttgtttgtc
     3361 atgaacgaaa atcaattctc tatttttgaa aaataacaag aaaaacttgt taaaaatatt
     3421 taaagtaagt gggtggatta ttttatgtca tatacaggaa ttttgagtct cgaagatatt
     3481 tgtcactacg gtaaacggtg taccgctaca gagaagatca cgaagaaact atcaactggc
     3541 caaaataaaa ccgttgtgca gtgtaagaaa tatataatcc aaaaagacaa agtctcagag
     3601 gaaatgattt attacgttgg gaaacaaaag caaataattt taaaagatcc tatcccttta
     3661 aaagagctat atccaacaat caaacatgtt tatgaccaaa acggtgtatt gataggtcga
     3721 agaaaaaatg gagtcttacg ttgtaccgca aaagggatgg ggcgtttgat cagctgaatt
     3781 gatcattctt ataacttgta ttttatcgtt tttcgcttgc ttgaaaatat tgtcgagact
     3841 tctaaaagaa cttagaatca ctagaaaaat aaggagtaga cttgatctat caacaattcc
     3901 cttcggggag tgatggggta ggtttttacg attggtaacg taaaaaattg gtcaatcgag
     3961 taaatgccct tgtttggata gtggtgaaat gaatttgtgt aaataatatg cacagagtaa
     4021 acaagaggga atttagaagt tagacaagtt agaatagcgc ctagatggtt ctgttgcaaa
     4081 gttttaaata aagaataaaa tcccttacgg tatctatgat ttaagctggg attcccaata
     4141 ataccttgat ttcagtacag accgaaaacc cgaagagagt gccttctttt cggctctata
     4201 atttatggga ctgatgaatc agaattgatt cttcagcccc attttcattt taggtattaa
     4261 aaaacatatc gttctctagt atgattaaat caccacaaaa taaacaactg agaggacgat
     4321 acgctatatg aatgattcta tcaaaaaaat gctgagaata acagagaaag atttgatgat
     4381 tacagaggtc tcttacgaga cccttcagaa gaaaaagacg ttggtcgtcg atgctgttct
     4441 ctcgcctact cctcgtgctt gtagaagttg tggttctact gtggtagatg gaaacgggaa
     4501 agcaattata gtgaaaaatg gaaaaaagga aacgattgtc cgttttgaac aatacaatca
     4561 tatgcctttg gttatgcgcc taaaaaagca acgctatacc tgtaaaaact gtcgcaccca
     4621 ttggacggct caaagttatt ttgtccaacc cagacattca atcgcaaatc atgttagata
     4681 taaaattgct tctttactga ctgaaaaagt atctttatct tttattgcga aaagctgtca
     4741 ggtatctttg accaccgtta ttcgtacatt gaaagagttt aaaagctatt taccaaagca
     4801 atctaagaag atcctcccca gagtattgat ggttgacgaa tttcgttcgc atgcttccat
     4861 agaagataag atgagcttta tttgcgcgga tggcgaaaca ggaaaattaa tagatgtttt
     4921 gcctacgcgt aaattacctc gattaacaag ctatttctta ggttgtacca atccagaaga
     4981 agtagaattc ttggtgacag acatgaacgc cgcctacttc cagctcacca aacgtgttct
     5041 gccaaatgcg aaagtcgtga ttgatcggtt tcatattgtc aaacacatga atcaagcgtt
     5101 caatgagttg cgtatccgtg aaatgaatga acttcgtaaa gccggacaga aaagccaggc
     5161 agaaaaactg aaaaagaact ggcgcttttt gctaaaaaat cgtgcaaaca tcaaccatta
     5221 tgaatacaaa acatggaaaa gtttccgagc accaaaatac ccatttctta ctgaagcaat
     5281 gatgattgat cgattgcttg agttttctcc gcccctaaag gaggcgtatc ccttttttca
     5341 tgaattagtt gaagcctttc gagacaaaga ccctgactta tttttctcct tattggcaga
     5401 acttcccgaa acgttagatg acagctttcg ggaaaagctt caaaaccttc tgacctatga
     5461 agaaggcatc accaacgcaa tgatctatcc ttattccaat ggaaaaatag aagcgaagaa
     5521 tacccacata aagacaatga aacgagtatc ctacggattt aaatcatttg agaacatgag
     5581 aattagaatc tttttgatca atcaattaat caatgtaaga taacaaaaaa tctgagccag
     5641 aatgtggttc attctgactc agatttgatt ttgcacaact catcagtcct tattgacaaa
     5701 gagccttctt ttcgggtttt cttatataat cctcgaatgg cttccatgcc tttaatcgtg
     5761 gtagaggcag tgcgtaaact tcgatagaat ttattgcgtc tctttactgg acgatggtct
     5821 tgttcaatca aattattcag gtatttaatg gtacgatgtt ctgtcccttg ataaaagccg
     5881 tattctttta gtttcttaaa ggcacttgta atagaggggg ctttatctgt gactacaacc
     5941 ttcggttcat caaactgctt cactaaccgc ttaagaaaag cataggctgc ttgtgtgtcc
     6001 cgttttttac gtaaccaaat atccaaggtt aaaccatctg catcgatggc tcgatacaaa
     6061 taatgccatt ttcctttaat tttgatgtac gtttcatcca ttttccatga ataaaaggat
     6121 tttttatttt tctttttcca aatttgatag agtagtttgc catattcttg cacccaacga
     6181 taaatcgtcg tatgagaaac gttaatgcca cgatcatata agatttcttg aacttcacga
     6241 tagctaaggt tataacgaag atagtagccc acggctacaa taatcacatc ctgctgaaat
     6301 tgctttcctt taaaatgatt catcgtcatt cctcctgcta tctttttcta ttattctacc
     6361 ttatttgata gtagatttaa aactttgcaa cagaaccgtt ggtcaaacgt aaaacgaact
     6421 gtcttatccc ctttttcacg cattctagac acgatggaaa aaaacaaatt catttcaacc
     6481 ggtgtaaatt ttcttaaagg aattgtattt aattcatggt ggtattttac aatctcatta
     6541 gccatataat cacctcaatc caattatgaa tgacattttt taaatgtcaa gacattcata
     6601 tttgacgttc aaacagacaa aatgtccttc ataaacagac aaaatgtcct tcataaacag
     6661 acaaaatgtc cttcataaac agacaaaatg tccttcataa cattctgtat ccattggtag
     6721 agtaaggaca cagcttacgg taaagaggtt taaaaagagg tttaaaaaga gatataaaaa
     6781 gaggggggct aattttcccg cctaaaaacc acttcttttt tctttaaaca ggttcgcgca
     6841 tttttcaaaa ctgccaatcc aaaaccttgc ttcctacggt cgccaaaaag gtgtgatcgc
     6901 tacgctctca cattgtactg cgcagtcgcc taaaggctcc tttgctaaaa acatgttggt
     6961 aaagaggcct ttgagcggtt ctgaatgctt atctaagccg ttttaagaca gtcttggata
     7021 aaaatcctta tctagcttta aagcgcctta caggcggtca gggcaagccc taacaaccct
     7081 aaaataagcg atacttaaaa acaccacaca agtttaattt tttaagatat aataacttgt
     7141 cgcctatccg acagtcttgc gactggaagg aggtgtatct aatgtttgaa ttgttcattt
     7201 gcccccttct tatagaagtt tgtgtctctt tattcagtta ttggttgaat aaccgaaaca
     7261 agaagtaaaa tcaataaagg cgacatcaac ctgaaaaaaa gccccagaga atccaacctc
     7321 tctggggctt tcgtgtatct aatgtttgat catttgcatg tttagtttaa catgattgcc
     7381 gatcaaattc aattttgctg ttgctgatct aaccattcct tgacactttt tagataattt
     7441 aatgccgttt cttttttcgt tggattttgt atgttcgttg cttgctgaag cagtgcttta
     7501 taacgttcgt aggtaactga ttgttgccgt tcttttcgtt cctgttcact agttgaaaaa
     7561 gggattgtat cactgaataa attataacaa gcttcttctg tctgcgtatc tttaaaatat
     7621 tgcacgtctt ttttggttcg ctcatagttg tcttgaacct ctttttgctg tttttctggc
     7681 aagttttgat aaagacgagt gagtttttcc atgtttttat ccgtcaaacg tttttcttga
     7741 ttcacaaaaa tatcgttcat ttcctcataa caagtggtaa actcttccat tttttgtgtt
     7801 aacacttgct cctttttctt tttatcacat gctgcttcat acttttgagt gatatcccct
     7861 aataaaatac ttcttgaaat acgtttattt ccctctaaaa cgccgaataa accacttaaa
     7921 acgattgata atgtaaatat aacccctggc aataaaaacc tcttaaatcg aattttagag
     7981 ccttttaatg aatatcttgt ttgataagcc ttatagctaa gccaaataat tcctaaaata
     8041 ctggcaaaaa tgagtagata gggtaaatag aatgccattt ctatttattc tccccatacc
     8101 agccaaaagg ctaacagtgt catgattaag caacataagg gggcaagaat atccattgat
     8161 cgctgcataa ttactttttt ctgttcttta tttcgctggt ttaatagcgc atggtggaat
     8221 tttttgactt gtgaatcaat tgtagtttgt attctttctt tggtataagg tgcaagaaaa
     8281 gcacgttgtt tctttatttc attttctatg tcttgtaacg ttttagaacg ataattcttg
     8341 ttggtagtct gctcctcttt caacgtgttg gtcatggttt cttcgagtcg gtctaatttc
     8401 cggttgttca gtcgtaagag ttcgttgttc tcttcgtact tcttttgcag tttcgcgaat
     8461 gctagctcga gctcttcgta gctcgttggt tcgttgttga ttgtaggctc gttctcgtct
     8521 gtccagctca tgtaaaatcg tctccttttc gtaatccttt cctagtttgt tggatcgtac
     8581 ttttttcttt ttgtggatca attcgtaagt aaaatttttc ccacgattca agcaatgaat
     8641 gccgaatgtt ttaagagaat cacaaaattg gttatacgtt cgagtttttt tgtttttcat
     8701 tgtttgatca atcgcaaacc gaatttcgtc tttccaaaca ggttcatttt tttcttttaa
     8761 tttgatttca gacatggttc gtttttcggg tttcttccct cgttcagtga ttgttaagtc
     8821 atgttcaaga caaatctcgt catttaggtc ataacatttg tttaaaaatg cttgaccatg
     8881 ggcttgaaat ttgttcccag tttccagatt gacggagtta atgacaatgt ggttatgaat
     8941 atggtctttg tctgtatgtg tgtaaatcgc gatttggtgg tcaggggcta tttttttcgc
     9001 atactctgcc cctagttgat tggctttttc agcggtaatt tctcctggtc gaaaagactg
     9061 gatcaataag tgtgcttgta cacgatcgtc ttttccatac agcatgcgaa tttgtttcat
     9121 ttcgcttttg gcataatcaa tgtcacagtt tatccctgtt ttgacggttg ctcgtggttc
     9181 ggcgtaattg atcgctcggc tacaagaagt ggttcggctt actttaactg ttgccatatc
     9241 ttttgtagct ccttttgcat gatttttagg ttttcggata agcgttgggc gtcgccagga
     9301 tcaacgtcgt gttggtgtgt gttgcaccac ttggcaattt gattgatatt cccgccagct
     9361 ttggctaaat cgcgcgcgat tgcctgagca atgtctggcg ccactttcgg tgtcaccaga
     9421 cgcgcgtttt gtgccttggc ttttacgaaa gccggcacac tcatttgcaa agcttcagct
     9481 gactgcttca gctttgcaaa ttcagattcg ctcactcgaa aactgatttg ttttggctcg
     9541 gatcgatagg tatatttttt agaatgattg ctagccaaat attgattttg ttcgctcata
     9601 agtcccaccc tttcagtacg tcctacggac gtatcgttcg caataccatt gtacctaaaa
     9661 aggtacaata agtaaagctc actaaagctt actaaagggc ttggcaagct ctatatttgc
     9721 tagccaaata cctacgtatt tggtgcaaat aaccgcttgt caaaggggcg caagctcccc
     9781 cttgaatccc cctccccccc cactctccac aatacaaaaa agactagcaa atgctagcca
     9841 ctttttgtaa agtttcgctt gtttcacctt cggtgaaatt gttgcaaatc aataattagg
     9901 tagagctaca tttttttcgt tgttcaaaga ttcttatgcc atttactatt aataaatcta
     9961 taaatatgat aatttttcgg ctctataatt tatgggactg atgaatcaga attgattctt
    10021 cagtcccatt ttcattttat tccaaagaat taactccaaa taccaataga agcccatcct
    10081 ctatatactt gagattcctt actaacaatt tcttgtaatt ctattaaaga tttaggtaat
    10141 ccaaatttat gttttaaaat atatcttcca agaaaactac ttaatttcat actaacttca
    10201 ccaacacttt ttccctcact gatttcttta gaataaagaa agagcttttc ttttaagtca
    10261 ggatagtcat ctatagttgc ttcattgtat actttactaa ttgcatttaa aagtttttct
    10321 tctttagtaa aatccattat aataacctcc ctaccactac cttctaggtg cccatggacc
    10381 atgattaacc caaccattaa caataatttt tccaatttct cctttagctt gattccaatc
    10441 tacccaacat ttttctttgt tacaataaag accatttcca tagtaagtag ctgcatcaac
    10501 ttttattcct gtaccgatgc cagctagaca agttcctaat attcctagaa taacacaatg
    10561 ttttaatact ttctttttca tgattgtttt tccttttcgt ttttttaaaa ttgcttgtta
    10621 tattaaataa tcttagtaat tttattatat aacattttat tatataacaa tgattaacgt
    10681 cataaaaagt agttttgaat tcataatcgt ttaaataaaa ttataagatc agttatttaa
    10741 acagctagta gacataatgt atatactacc aagtaacgcc tgtaccaagg gatccaggcg
    10801 ctgattttgt gaatttttat tggtctaggt taaaagctct ttttaaggct tggttttctg
    10861 cggttgtttc tttctaattc tttgtgaata ttgatcggtc attttttaaa tacttgttat
    10921 ttttgtttgt gtttgttatg ctttttacat atctcatatt catttattat tcttttctaa
    10981 ggttaataat aggataatct ctttcagaaa gactgctcgt acgagcagtc ttttcttatt
    11041 tatcaagttt ttctacaaat acttcctcat tttgactgtt gtagtaatta ggattgagtt
    11101 ttagttcccc ttttttattt cctttgttgg ccactgataa taacattggg ctaaagctta
    11161 atattcctag taggatagaa ccgaatagca agtgtttttt tgtcataagt atttccttct
    11221 tcatttccat agctgccacc attttttcca attctttgtt tgttcgtcca ttgtttctgt
    11281 tgcttcagaa agagtcgttg aactattctc tgaagactct tccgtataag tcaactgcag
    11341 ttgctcctga agtttttcga tttgttggtt ggcttgcagg gtgagttgtt gttgctggtc
    11401 gagtagtttt tgtatatgag aattattttg ctctttgagg gcaagttgtt ctcgtaaaaa
    11461 ttcattttct tcacgcaact gatctagcaa cttgtttgca accacgtttt tgtttggtat
    11521 ataagcattt ttatcgttgt tttgttcatg tttatgcaac ttatctagca acctttgatt
    11581 gtctaagttg cgagcaagtt gcaatactcc agaacgcaat acaaccttat aaccacgctc
    11641 atttttagct atcatggaag aatctaattt ttggatatgt ttcgatattg cttgcctact
    11701 catcttaaaa agatctgaca attcctttat tgtaaaggtt tcttgtggtt gcatactggt
    11761 tgcctcctag gttgctactg gaataaatta tctaaatcag ataataaact ttttttctct
    11821 ttttccgaaa gtgcggactc tgtttgtttt tcaagagctt ttttctcttt ttctagttgt
    11881 ttgatttgtt ggaggagttc aagttctcgt ttcttctgtt tgattttttc gttaattgtt
    11941 gtagcgggtt cttcgtattc tttttgttta tcagctaaag ccaatgcttt attttggtct
    12001 tctttggttg gtgcatgttt gttaaagtcg tctgcttttt tgatctcagg tttgaacgta
    12061 aattgatagc caataacagg ttttccccgt ccttttccgt atttcttttt gattgttagt
    12121 cctttgaaga ttgcagttag ttcttgacgt ataggtttta taactcgttt atctatatca
    12181 ggttgcttat aacttttagg aatatctaat aattcaagaa agggttctgt tgcaaagttt
    12241 taaataaaga ataaaatccc ttacggtatc tatgatttaa gctgggattc ccaataatac
    12301 cttgatttca gtacagaccg aaaacccgaa gagagtgcct tcttttcggg ttttcttata
    12361 taatcctcga atggcttcca tgcctttaat cgtggtagag gcagtgcgta aacttcgata
    12421 gaatttattg cgtctcttta ctggacgatg gtcttgttca atcaaattat tcaggtattt
    12481 aatggtacga tgttctgtcc cttgataaaa gccgtattct tttagtttct taaaggcact
    12541 tgtaatagag ggggctttat ctgtgactac aaccttcggt tcatcaaact gcttcactaa
    12601 ccgcttaaga aaagcatagg ctgcttgtgt gtcccgtttt ttacgtaacc aaatatccaa
    12661 ggttaaacca tctgcatcga tggctcgata caaataatgc cattttcctt taattttgat
    12721 gtacgtttca tccattttcc atgaataaaa ggatttttta tttttctttt tccaaatttg
    12781 atagagtagt ttgccatatt cttgcaccca acgataaatc gtcgtatgag aaacgttaat
    12841 gccacgatca tataagattt cttgaacttc acgatagcta aggttataac gaagatagta
    12901 gcccacggct acaataatca catcctgctg aaattgcttt cctttaaaat gattcatcgt
    12961 cattcctcct gctatctttt tctattattc taccttattt gatagtagat ttaaaacttt
    13021 gcaacagaac cgccattctg tattccgcta atgggcaata tttttaaaga agaaaaggaa
    13081 actataaaat attaacagcc tcctagcgat gccgaaaagc cctttgataa aaaaagaatc
    13141 atcatcttaa gaaattctta gtcatttatt atgtaaatgc ttataaattc ggccctataa
    13201 tctgataaat tattaagggc aaacttatgt gaaagggtga taactatgag cgataaaata
    13261 cttattgtgg atgatgaaca tgaaattgcc gatttggttg aattatactt aaaaaacgag
    13321 aattatacgg ttttcaaata ctataccgcc aaagaagcat tggaatgtat agacaagtct
    13381 gagattgacc ttgccatatt ggacatcatg cttcccggca caagcggcct tactatctgt
    13441 caaaaaataa gggacaagca cacctatccg attatcatgc tgaccgggaa agatacagag
    13501 gtagataaaa ttacagggtt aacaatcggc gcggatgatt atataacgaa gccctttcgc
    13561 ccactggagt taattgctcg ggtaaaggcc cagttgcgcc gatacaaaaa attcagtgga
    13621 gtaaaggagc agaacgaaaa tgttatcgtc cactccggcc ttgtcattaa tgttaacacc
    13681 catgagtgtt atctgaacga gaagcagtta tcccttactc ccaccgagtt ttcaatactg
    13741 cgaatcctct gtgaaaacaa ggggaatgtg gttagctccg agctgctatt tcatgagata
    13801 tggggcgacg aatatttcag caagagcaac aacaccatca ccgtgcatat ccggcatttg
    13861 cgcgaaaaaa tgaacgacac cattgataat ccgaaatata taaaaacggt atggggggtt
    13921 ggttataaaa ttgaaaaata aaaaaaacga ctattccaaa ctagaacgaa aactttacat
    13981 gtatatcgtt gcaattgttg tggtagcaat tgtattcgtg ttgtatattc gttcaatgat
    14041 ccgagggaaa cttggggatt ggatcttaag tattttggaa aacaaatatg acttaaatca
    14101 cctggacgcg atgaaattat atcaatattc catacggaac aatatagata tctttattta
    14161 tgtggcgatt gtcattagta ttcttattct atgtcgcgtc atgctttcaa aattcgcaaa
    14221 atactttgac gagataaata ccggcattga tgtacttatt cagaacgaag ataaacaaat
    14281 tgagctttct gcggaaatgg atgttatgga acaaaagctc aacacattaa aacggactct
    14341 ggaaaagcga gagcaggatg caaagctggc cgaacaaaga aaaaatgacg ttgttatgta
    14401 cttggcgcac gatattaaaa cgccccttac atccattatc ggttatttga gcctgcttga
    14461 cgaggctcca gacatgccgg tagatcaaaa ggcaaagtat gtgcatatca cgttggacaa
    14521 agcgtatcga ctcgaacagc taatcgacga gttttttgag attacacggt ataacctaca
    14581 aacgataacg ctaacaaaaa cgcacataga cctatactat atgctggtgc agatgaccga
    14641 tgaattttat cctcagcttt ccgcacatgg aaaacaggcg gttattcacg cccccgagga
    14701 tctgaccgtg tccggcgacc ctgataaact cgcgagagtc tttaacaaca ttttgaaaaa
    14761 cgccgctgca tacagtgagg ataacagcat cattgacatt accgcgggcc tctccgggga
    14821 tgtggtgtca atcgaattca agaacactgg aagcatccca aaagataagc tagctgccat
    14881 atttgaaaag ttctataggc tggacaatgc tcgttcttcc gatacgggtg gcgcgggact
    14941 tggattggcg attgcaaaag aaattattgt tcagcatgga gggcagattt acgcggaaag
    15001 caatgataac tatacgacgt ttagggtaga gcttccagcg atgccagact tggttgataa
    15061 aaggaggtcc taagagatgt atataatttt ttaggaaaat ctcaaggtta tctttacttt
    15121 ttcttaggaa attaacaatt taatattaag aaacggctcg ttcttacacg gtagacttaa
    15181 taccgtaaga acgagccgtt ttcgttcttc agagaaagat ttgacaagat taccattggc
    15241 atccccgttt tatttggtgc ctttcacaga aagggttggt cttaattatg aataacatcg
    15301 gcattactgt ttatggatgt gagcaggatg aggcagatgc attccatgct ctttcgcctc
    15361 gctttggcgt tatggcaacg ataattaacg ccaacgtgtc ggaatccaac gccaaatccg
    15421 cgcctttcaa tcaatgtatc agtgtgggac ataaatcaga gatttccgcc tctattcttc
    15481 ttgcgctgaa gagagccggt gtgaaatata tttctacccg aagcatcggc tgcaatcata
    15541 tagatacaac tgctgctaag agaatgggca tcactgtcga caatgtggcg tactcgccgg
    15601 atagcgttgc cgattatact atgatgctaa ttcttatggc agtacgcaac gtaaaatcga
    15661 ttgtgcgctc tgtggaaaaa catgatttca ggttggacag cgaccgtggc aaggtactca
    15721 gcgacatgac agttggtgtg gtgggaacgg gccagatagg caaagcggtt attgagcggc
    15781 tgcgaggatt tggatgtaaa gtgttggctt atagtcgcag ccgaagtata gaggtaaact
    15841 atgtaccgtt tgatgagttg ctgcaaaata gcgatatcgt tacgcttcat gtgccgctca
    15901 atacggatac gcactatatt atcagccacg aacaaataca gagaatgaag caaggagcat
    15961 ttcttatcaa tactgggcgc ggtccacttg tagataccta tgagttggtt aaagcattag
    16021 aaaacgggaa actgggcggt gccgcattgg atgtattgga aggagaggaa gagtttttct
    16081 actctgattg cacccaaaaa ccaattgata atcaattttt acttaaactt caaagaatgc
    16141 ctaacgtgat aatcacaccg catacggcct attataccga gcaagcgttg cgtgataccg
    16201 ttgaaaaaac cattaaaaac tgtttggatt ttgaaaggag acaggagcat gaatagaata
    16261 aaagttgcaa tactgtttgg gggttgctca gaggagcatg acgtatcggt aaaatctgca
    16321 atagagatag ccgctaacat taataaagaa aaatacgagc cgttatacat tggaattacg
    16381 aaatctggtg tatggaaaat gtgcgaaaaa ccttgcgcgg aatgggaaaa cgacaattgc
    16441 tattcagctg tactctcgcc ggataaaaaa atgcacggat tacttgttaa aaagaaccat
    16501 gaatatgaaa tcaaccatgt tgatgtagca ttttcagctt tgcatggcaa gtcaggtgaa
    16561 gatggatcca tacaaggtct gtttgaattg tccggtatcc cttttgtagg ctgcgatatt
    16621 caaagctcag caatttgtat ggacaaatcg ttgacataca tcgttgcgaa aaatgctggg
    16681 atagctactc ccgccttttg ggttattaat aaagatgata ggccggtggc agctacgttt
    16741 acctatcctg tttttgttaa gccggcgcgt tcaggctcat ccttcggtgt gaaaaaagtc
    16801 aatagcgcgg acgaattgga ctacgcaatt gaatcggcaa gacaatatga cagcaaaatc
    16861 ttaattgagc aggctgtttc gggctgtgag gtcggttgtg cggtattggg aaacagtgcc
    16921 gcgttagttg ttggcgaggt ggaccaaatc aggctgcagt acggaatctt tcgtattcat
    16981 caggaagtcg agccggaaaa aggctctgaa aacgcattta taaccgttcc cgcagacctt
    17041 tcagcagagg agcgaggacg gatacaggaa acggcaaaaa aaatatataa agcgctcggc
    17101 tgtagaggtc tagcccgtgt ggatatgttt ttacaagata acggccgcat tgtactgaac
    17161 gaagtcaata ctctgcccgg tttcacgtca tacagtcgtt atccccgtat gatggccgct
    17221 gcaggtattg cacttcccga actgattgac cgcttgatcg tattagcgtt aaaggggtga
    17281 taagcatgga aataggattt acttttttag atgaaatagt acacggtgtt cgttgggacg
    17341 ctaaatatgc cacttgggat aatttcaccg gaaaaccggt tgacggttat gaagtaaatc
    17401 gcattgtagg gacatacgag ttggctgaat cgcttttgaa ggcaaaagaa ctggctgcta
    17461 cccaagggta cggattgctt ctatgggacg gttaccgtcc taagcgtgct gtaaactgtt
    17521 ttatgcaatg ggctgcacag ccggaaaata acctgacaaa ggaaagttat tatcccaata
    17581 ttgaccgaac tgagatgatt tcaaaaggat acgtggcttc aaaatcaagc catagccgcg
    17641 gcagtgccat tgatcttacg ctttatcgat tagacacggg tgagcttgta ccaatgggga
    17701 gccgatttga ttttatggat gaacgctctc atcatgcggc aaatggaata tcatgcaatg
    17761 aagcgcaaaa tcgcagacgt ttgcgctcca tcatggaaaa cagtgggttt gaagcatata
    17821 gcctcgaatg gtggcactat gtattaagag acgaaccata ccccaatagc tattttgatt
    17881 tccccgttaa ataaactttt aaccgttgca cggacaaact atataagcta actctttcgg
    17941 caggaaaccc gacgtatgta actggttctt agggaattta tatatagtag atagtattga
    18001 agatgtaagg cagagcgata ttgcggtcat tatctgcgtg cgctgcggca agatagcctg
    18061 ataataagac tgatcgcata gaggggtggt atttcacacc gcccattgtc aacaggcagt
    18121 tcagcctcgt taaattcagc atgggtatca cttatgaaaa ttcatctaca ttggtgataa
    18181 tagtaaatcc agtagggcga aataattgac tgtaatttac ggggcaaaac ggcacaatct
    18241 caaacgagat tgtgccgttt aaggggaaga ttctagaaat atttcatact tccaactata
    18301 tagttaagga ggagactgaa aatgaagaag ttgttttttt attgttattg ttattcttaa
    18361 tatacttagg ttatgactac gttaatgaag cactgttttc tcaggaaaaa gtcgaatttc
    18421 aaaattatga tcaaaatccc aaagaacatt tagaaaatag tgggacttct gaaaataccc
    18481 aagagaaaac aattacagaa gaacaggttt atcaaggaaa tctgctatta atcaatagta
    18541 aatatcctgt tcgccaagaa agtgtgaagt cagatatcgt gaatttatct aaacatgacg
    18601 aattaataaa tggatacggg ttgcttgata gtaatattta tatgtcaaaa gaaatagcac
    18661 aaaaattttc agagatggtc aatgatgctg taaagggtgg cgttagtcat tttattatta
    18721 atagtggcta tcgagacttt gatgagcaaa gtgtgcttta ccaagaaatg ggggctgagt
    18781 atgccttacc agcaggttat agtgagcata attcaggttt atcactagat gtaggatcaa
    18841 gcttgacgaa aatggaacga gcccctgaag gaaagtggat agaagaaaat gcttggaaat
    18901 acgggttcat tttacgttat ccagaggaca aaacagagtt aacaggaatt caatatgaac
    18961 catggcatat tcgctatgtt ggtttaccac atagtgcgat tatgaaagaa aagaatttcg
    19021 ttctcgagga atatatggat tacctaaaag aagaaaaaac catttctgtt agtgtaaatg
    19081 gggaaaaata tgagatcttt tattatcctg ttactaaaaa taccaccatt catgtgccga
    19141 ctaatcttcg ttatgagata tcaggaaaca atatagacgg tgtaattgtg acagtgtttc
    19201 ccggatcaac acatactaat tcaaggaggt aaggatggcg gaatgaaacc aacgaaatta
    19261 atgaacagca ttattgtact agcacttttg gggtaacgtt agctttttaa tttaaaaccc
    19321 acgttaacta ggacattgct atactaatga tacaacttaa acaaaagaat tagaggaaat
    19381 tatattggga aaaatattat ctagaggatt gctagcttta tatttagtga cactaatctg
    19441 gttagtgtta ttcaaattac aatacaatat tttatcagta tttaattatc atcaaagaag
    19501 tcttaacttg actccattta ctgctactgg gaatttcaga gagatgatag ataatgttat
    19561 aatctttatt ccatttggct tgcttttgaa tgtcaatttg gttctgttgc aaagttttaa
    19621 atctactatc aaataaggta gaataataga aaaagatagc aggaggaatg acgatgaatc
    19681 attttaaagg aaagcaattt cagcaggatg tgattattgt agccgtgggc tactatcttc
    19741 gttataacct tagctatcgt gaagttcaag aaatcttata tgatcgtggc attaacgttt
    19801 ctcatacgac gatttatcgt tgggtgcaag aatatggcaa actactctat caaatttgga
    19861 aaaagaaaaa taaaaaatcc ttttattcat ggaaaatgga tgaaacgtac atcaaaatta
    19921 aaggaaaatg gcattatttg tatcgagcca tcgatgcaga tggtttaacc ttggatattt
    19981 ggttacgtaa aaaacgggac acacaagcag cctatgcttt tcttaagcgg ttagtgaagc
    20041 agtttgatga accgaaggtt gtagtcacag ataaagcccc ctctattaca agtgccttta
    20101 agaaactaaa agaatacggc ttttatcaag ggacagaaca tcgtaccatt aaatacctga
    20161 ataatttgat tgaacaagac catcgtccag taaagagacg caataaattc tatcgaagtt
    20221 tacgcactgc ctctaccacg attaaaggca tggaagccat tcgaggatta tataagaaaa
    20281 cccgaaaaga aggcactctc ttcgggtttt cggtctgtac tgaaatcaag gtattattgg
    20341 gaatcccagc ttaaatcata gataccgtaa gggattttat tctttattta aaactttgca
    20401 acagaaccaa aaataaagta gtaaattaat cataatcttt tcaacaacag gaatagtcaa
    20461 gttagactgt tcctgttgtt tctttatttt ccttatcatc ttcaactttt tcaaatactg
    20521 caaatacaaa atatcaatat aacttattcg ttctatcaat cagttcctaa tatctactca
    20581 tcaaaatgaa atttcaaact aatctcatca tagtattctt ttcgtcgatt gtaaaattaa
    20641 gctagacaac taaaaagatc atttgtgcta cactcaaaat agttccgacc aaagaattat
    20701 taaggagtga gtacaaatga cctacaccca tcttacaaca gacgaactgg taatcataga
    20761 gtcttatttc aaaaataatc aatccgttgc caaaactgcg caatgcttag gacgtgcgtg
    20821 acaaacgatt cataacgtgt atcaattttt gaaaactggt gctacgatac tgaactacta
    20881 tcaacaatac aaagaaaaca aaaaacgctg cggtagacgc tcgattgctt taccagagga
    20941 acaaaaagaa tatgttcaaa agagggttgt tcaagggtgg acaccggatg tgattgtcgg
    21001 ccgctcggaa atgaaacttg attgttcagt ccgtacactg tatcgaatgt ttcaaactgg
    21061 cgcatttaat gtgcgtgatt tgcctatgaa aggcaaacga aaaccaaatg gacaccaaga
    21121 aaaacgtggg aaacaagctt ttcggcgcag tatacatgag cgcatcaagg agcatccaga
    21181 atttgaaaac gagtttggcc atcttgaagg agacactatt gtcggtcgaa aacacaaaag
    21241 tgctgttatt acattggtgg aacgtttgtc aaaagtgatt attacattga agccagccgg
    21301 tagacaggca atggacattg aaaatcgaat taatcattgg tttcaaacgg ttcctaaaca
    21361 tctgtttaaa tcaattacgt ttgactgtgg gaaagaattt tcaaattgga aagctatggg
    21421 aaatcaaaat gatattgata tttattttgc ggatccaggc accccgtcac aacgcgctct
    21481 aaatgaacat tcaaatggat tattacgtcg tgatggatta gttaaagcca tggacttcaa
    21541 tgaagtatca gaatcattta tagagtacag aaaacatttt ctgtactcta ttttgtcttc
    21601 ttttaaattt tcaatagatt atatctattg tgaattttgt agagggtcag aaacttaata
    21661 gtttttgaca catggttaaa ttcgcgatac aataggattt gtagtgtttc ataaacttat
    21721 gtcaaaaagt taaggggatt ttccatgatt ttagaaaata aattgggttt aacgaatcag
    21781 gttgagttgg ccaaggctga agaaaaactc agtaagcaaa aagcaaaaga attatatgat
    21841 tctggaaaaa taaatgaaat cgaagtcggc acgtttaaag gcttgtctga aattcatgat
    21901 tttctctttt cagaaattta tgattttgca ggaaaaattc ggacagttaa tattgcaaaa
    21961 ggaaattttc gttttgcgcc ggtcatgtac ctagaacaat ctttaaatca tattgatcag
    22021 atgccgcaaa cttctttcga agagattatt aagaaatacg tggaaatgaa tatcgctcac
    22081 ccttttcgcg aaggaaacgg gcgcagtact agaatttggc tggatctcat tttaaaggaa
    22141 gaattgcaaa aagtggtcga ttggaacttg atcgataaag cagactatct ttctgcaatg
    22201 gagcgcagtc caataaatga cttggaaata cgctatctca tttccaatgc cctgactgat
    22261 aaaattgacg atcgtgagtt atatatgaaa ggaatcgatg tcagctactt ctatgaagga
    22321 tactctgagt atacgataga tgatttgtaa aagcaggtga gttaaatgac aaaatatggc
    22381 tatgcacgtg tctcaaccgc ttctcaaagt acaaaggaac agatacaaca gctacttgag
    22441 aacggtgttg agaagaagaa tattttttct gaaaaattta caggtacgaa acgagatcgg
    22501 ccaaagttta atcagctgtt ggctggtctg aagcctggag acgaaatcgt tgttacgaaa
    22561 cttgatcgat tcgcccgtaa tacaagagaa gcactagaga tcattgaacc tttactcgat
    22621 gataacgtca cgattaaggt attgaatcta gggacgatcg aaaatacatc gatgggtcga
    22681 atggttacac gtacgttgtt gagtgtagct gaaatggacc gtgatatgat tgtagaacgt
    22741 actcaggaag ggaaattatt tgcgaaaaag aataatccta attttaaaga gggacgtccg
    22801 aaagcaacaa tcacaccaaa gaagaggcat gcatatgaat tgattacttc cggcaaatcg
    22861 tataaagaag tggaagccat aacgggtttc agtcgtagta cactttttag aattaagaaa
    22921 caaatagaag cgagtgagta gaagattgat aaaattaata taaaaatctc ttttaaatca
    22981 aataaatcgt tgtttatacg agcattctaa ggtcaggttc actcattaag atgtatcatt
    23041 ggtcgaacga agcgtcatac cagctacgaa tagacatatt tttagggagg aacgaagtaa
    23101 atgaaagaac aacaattagg ctacactctt tggggacgtc cattatacgg attagaacga
    23161 agaacggctg tatcgattga ctgtgcttgt ggtgagttga ttcaactcaa tattcaaacg
    23221 aaacaataca attgtaaaaa ttgtgggaat tgttaccaat tcattgatca agacttccaa
    23281 ttgctaaacg aaaaaaacaa ataggtttat tatagtcaga caattgtctg gctatttttc
    23341 tatttagaga agatcctcgt tgcaaacacg aacgtatgtt tgtataatat gagagaagag
    23401 ggggagaact ttatgcttga ttactcaaaa gagccagtca atgactactt tctaatcgat
    23461 atgaaaagtt tttacgcaag tgtcgaatgt atagaaagaa atttagatcc attaacgact
    23521 gaattagttg tcatgagtcg agcggataat acaggatcag ggttgatttt agcttcttca
    23581 ccagctgcaa agaagaaata tggtatttct aatgtcagca gaccacggga tctaccacag
    23641 cctttcccta aaacattaca tgttgttcca ccacgtatga acctttatat taagcgtaat
    23701 atgcaggtaa ataatatttt cagaagatat gtggctgatg aagatctact gatttactcg
    23761 atcgatgaat caatcttaaa agtgacccga tcactgaatc tttttacgac tgaaggaaca
    23821 cgaagtcagc gaaggaagaa tctcgctcaa atgatccaag aacgtattaa agaagagcta
    23881 ggattgattg ctacggtagg cgtcggcgat aatccccttt tggctaaatt agccttagac
    23941 aatgaagcaa agcataatga aggatttatt gcggaatgga cgtacgaaaa cgttcctgag
    24001 aaagtatgga atattcccga aatgacggac ttttggggaa ttggttcgcg aatgaaaaaa
    24061 aggctcaacc aaatgggaat tttgagcatt agagaccttg ctaactggaa tccttatacg
    24121 attaagaata gattaggtgt gattggatta cagctgtact tccatgctaa cggaatcgat
    24181 cgaacagata tagcaatccc gccagaaccg acaaaggaaa aatcttatgg taattcacaa
    24241 gtgttaccac gagattatac tagaagaaat gaaatcgagc tggtggtaaa agaaatggcg
    24301 gaacaagtag ccattcgtat caggcagcat aattgcaaaa caggatgtgt ccatttaaac
    24361 attggtacgt cgatcttaga aacgagacca ggattttcac accagatgaa aatccctatc
    24421 acagataata caaaggaatt gcagaattat tgtcttttct tgtttgataa gtattatgaa
    24481 ggacaagaag taaggcacgt tggaataacc tatagcaagc tagtttatac tgattcgctt
    24541 cagctggact tgtttagtaa tccacaaaaa cagattgatg acgaaaaact agacaaaata
    24601 atagataaaa ttaggcagaa gtatggtttt acgtcaattg tacatgcttc ttcgatgtta
    24661 gaaggcgctc gtagtattac tagaagcacg ttggttggtg gccatgcagg cggcgcaggg
    24721 gagcttaaaa atgattgact ataacgatcg aggacgattg aaatgggtag gattctattt
    24781 gtccgatcac acggaagaga tcgatgcgga caatgagcaa cgtgcaaata ataatttggc
    24841 aaaagaacaa atgacgactg aagagatttc ggaagtattg aacgctgcag tcataaaaaa
    24901 tagatcagta tgtattcaaa aagaagaacg aaacgctgaa ggatattatc cagacgatat
    24961 tgttggaaag atcttaggta gtgatgagct ggggatctac gttggcaaat acaaaattca
    25021 ctacgacgaa atacgtcata tcgaatttta ccaggataat aaatggagtc gattagaatg
    25081 aacattatcc agcaatatga gctaaagtat ataacctttg atcagctatc agaagagatt
    25141 tggggttatg gccaacgttt gataaatgag gttggtgttg agcgcttctc tttctatgta
    25201 gaagttgcag caggttatca taattttagg ttttatattt tcccgttatt tatataaggt
    25261 attttacgga ttctatagag ttatctctat gaatcctttt ttgtttttac aaataggagt
    25321 agatactaga ataatgcgtg tgttaaacta ttattgcaat cgcaataata aaagaaagaa
    25381 ggcttacgca ccatgtctat caatacattt gtttactcgc acccgatcaa tgtttacatt
    25441 atcaagaatt taggaatcac tgtagaacaa ttttgtgagt tatatgcata cccacaagga
    25501 acagttgcaa gctggataac ccgacaacgt agaataaaat cattacctgc ttcatttgta
    25561 tatgatctaa gtcttgcttc tagtatgaat atgaccgatg tatacgaaaa gttattaata
    25621 ctagaaaatg aatatgatca attcacttca aatcagcagc gaaaagtaaa gaaacagata
    25681 gactagaata gctattttcg aaaagcaata tctaaggtat aagttatacc ttaaataatt
    25741 aaagtataag ttataccata tatatttagg gtataactta tacttttatt cttaaaaacc
    25801 gctatatcca aacgttttta gatattatta tttaagttat acttttaatg ttgaccattt
    25861 ccgatatata agttatactt taattatcaa ttaaagattg ggaggattta catggatact
    25921 tttcaaggga ctacatttac agttggcaat tttaaaggag gagtaggtaa aactaagata
    25981 gtcagcatgc ttgcttatga caatgcaatg ataagaaata gaaaaacgct tattattgat
    26041 ttagaccctc aagcgaactt aacacaagtc atagcaagaa ctttcggtat aaccgatatc
    26101 aaaaccacta taacaaatgg tgtcgcaaat ggagaattag caagtagtat tattaaggta
    26161 aatgaaaatc ttgaccttct ggcatgtgac actagttttc gatcattctc cgcttttgct
    26221 aataaacatg aaaatgaatt agaccaagtt actgtcttga aaaaattact tcttccaata
    26281 aagaacaatt atcaagaaat atttattgat gtaccaccaa ccattagcga attttccgat
    26341 aatgctatgg cagcttcaga ctattcgata atttcatttc aaacagctga agaatcctta
    26401 gagggagtca acaaatatgt aaattatcaa aaattcatgg tcgatagata cgatcttgat
    26461 ttgcaaatta tagatattgt accttgtatg gtagaaccaa atgatgattt tgatgaagaa
    26521 atcctagaag aagcaattga aaaatacgga accgtggtat ccaaaaatct cattcattat
    26581 caaaaaagat tgagaaggta ttctaaaatt ggtatacatt taagaaaata caaaaatgga
    26641 aattttgatc aatgggatta taaagcacac caagtattta taaatatttt ggcagaacta
    26701 gatgctagac aagagttttt aaataaataa taaggagttg cataagtaat gcctaaagat
    26761 tttgatattc ctaaaatgat ggagaatggc gaatttgagc cattattacc caataacaaa
    26821 cgccaagatg tgaaaataag cggtgaatat aactttagca atagtgcatt gagtaacaca
    26881 aaaaatatta cattgaaaaa aagaggccga ccagtttcaa ttcctgataa aagaaacaag
    26941 gtatcagttc ctaaaaagat ctctccggca ttaaatagca aactctcaat tttacaagac
    27001 tatatgacgg agttacaaag tgaaaaaggg agaatttctt tcgaaaaaat tgttaataca
    27061 ttagcagact catatatcca gcatagacta ggagtagcaa aagaagaaca cataagagaa
    27121 gaaatacaag aagagtttga aaaattacca aaataatttt ttttcatgcg gtattcaatt
    27181 aaagtataag ttatactaga taaatgaata ttaaagtata agttatacat taaatattta
    27241 aagtataact taataaacaa cgtgtaaatt tgcgattaaa tcaacattat aaaattatta
    27301 tttaaagtat aagttataca ttatttgtat ttaaagtata acttatactt atttttttaa
    27361 tatataactt ataccttaaa tactgaaagt gttttattca cccttaatac atggtatagt
    27421 tcacttgttg aaaatcgtga atatatacaa gtttctatga agaaggagaa attta
//
