LOCUS       CP057079               27257 bp    DNA     circular BCT 13-MAY-2022
DEFINITION  Escherichia coli strain RHB38-C24 plasmid pRHB38-C24_5, complete
            sequence.
ACCESSION   CP057079
VERSION     CP057079.1
DBLINK      BioProject: PRJNA605147
            BioSample: SAMN15148394
KEYWORDS    .
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1  (bases 1 to 27257)
  AUTHORS   AbuOun,M., Jones,H., Stubberfield,E., Gilson,D., Shaw,L.P.,
            Hubbard,A.T.M., Chau,K.K., Sebra,R., Peto,T.E.A., Crook,D.W.,
            Read,D.S., Gweon,H.S., Walker,A.S., Stoesser,N., Smith,R.P.,
            Anjum,M.F. and On Behalf Of The Rehab,Consortium.
  TITLE     A genomic epidemiological study shows that prevalence of
            antimicrobial resistance in Enterobacterales is associated with the
            livestock host, as well as antimicrobial usage
  JOURNAL   Microb Genom 7 (10) (2021)
   PUBMED   34609275
REFERENCE   2  (bases 1 to 27257)
  AUTHORS   Shaw,L.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JUN-2020) Nuffield Department of Medicine, University
            of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. v0.4.7
            Assembly Name                     :: RH04 T3-C24
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 140.926036525725x
            Sequencing Technology :: Hybrid: Illumina and OXFORD_NANOPORE
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 06/19/2020 05:31:07
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 5,830
            CDSs (total)                      :: 5,691
            Genes (coding)                    :: 5,293
            CDSs (with protein)               :: 5,293
            Genes (RNA)                       :: 139
            rRNAs                             :: 8, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 103
            ncRNAs                            :: 14
            Pseudo Genes (total)              :: 398
            CDSs (without protein)            :: 398
            Pseudo Genes (ambiguous residues) :: 0 of 398
            Pseudo Genes (frameshifted)       :: 138 of 398
            Pseudo Genes (incomplete)         :: 233 of 398
            Pseudo Genes (internal stop)      :: 59 of 398
            Pseudo Genes (multiple problems)  :: 32 of 398
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..27257
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /strain="RHB38-C24"
                     /isolation_source="Pooled pig faecal samples collected from
                     floor of farm"
                     /db_xref="taxon:562"
                     /plasmid="pRHB38-C24_5"
                     /geo_loc_name="United Kingdom"
                     /collection_date="2017"
     gene            1..870
                     /locus_tag="HVZ77_28840"
     CDS             1..870
                     /locus_tag="HVZ77_28840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001212191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="QMC48026.1"
                     /translation="MRFQVRTVTGLTKVRHRNEVGVTLASLSLSAKRVLFLALCQIDSK
                     EMLNDEILEVDADLFSKTTTLDKYAAYAALKEGAKVLASTTLVLNRDDLKNLSNELGIA
                     TSKNKMPDRLDLNLTEFCAYYDHLAIVRIKFTNTAKRYFSKLIGSENRYTTQVLKSVVI
                     LNSVNSTNLYQVIRKYYSLNPASKSFEISVDQLKDEMGLYHIENGEKVYKYPKYSFFIR
                     DVINKSIKEIIEKTEIKTIKFTVVGKKGRMVHMLKFEYSLNEDTSISDEDAKFLEKFDK
                     VISYKQKG"
                     /name="replication initiation protein"
     gene            875..1726
                     /locus_tag="HVZ77_28845"
     CDS             875..1726
                     /locus_tag="HVZ77_28845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000435060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="QMC48027.1"
                     /translation="MEQIKLHKDSNVSIIVIPNHLLKNTGWDDGTLLDVVKSDNALHIR
                     RKEDVVDLVTKPCVDILTATFKNIKPGKIIKYNSKLNESLNKLHVSARRVFFICLYLYF
                     NGRYNSDGSILIRADKYAEFIGIDRTMAYKQMKDAADYFSSNIKLISLCDYIKNEGLLR
                     VALSTETINFISAVDGRKYQTTVVLYQSAVKLSGRYSWNLYQLIKSRLLDKSGAFSIKL
                     DELMIELNSRVNLEFKDYKKSVIGRSIDEIVEKTEIKSIKCVNAERQGRRVSKVRFEIE
                     MR"
                     /name="replication initiation protein"
     gene            1730..2173
                     /locus_tag="HVZ77_28850"
     CDS             1730..2173
                     /locus_tag="HVZ77_28850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001074376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QMC48028.1"
                     /translation="MAKIYQFPQGEERAKFRKEIARERKKRFAVKTGSTFVKWLGWGWF
                     YLRLLAASVLHFIFVFVLAILGAFKWAVFWLGGILCVITWYHLDHQLWTPQNLTIPVIT
                     ATWIFGLLAEPLMELLNKTMPWHKLLVPEPAGESIENSSETSQ"
                     /name="hypothetical protein"
     gene            2244..2345
                     /locus_tag="HVZ77_28855"
                     /pseudo=""
     CDS             2244..2345
                     /locus_tag="HVZ77_28855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001694628.1"
                     /note="incomplete; partial on complete genome; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DNA distortion polypeptide 3"
                     /name="DNA distortion polypeptide 3"
     gene            complement(2666..3484)
                     /locus_tag="HVZ77_28860"
                     /pseudo=""
     CDS             complement(2666..3484)
                     /locus_tag="HVZ77_28860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247724.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            complement(3524..4737)
                     /locus_tag="HVZ77_28865"
     CDS             complement(join(3524..4446,4446..4737))
                     /locus_tag="HVZ77_28865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558238.1"
                     /ribosomal_slippage=""
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="QMC48029.1"
                     /translation="MTKNTRFSPEVRQRAIRMVLESQDEYDSQWAAICSIAPKIGCTPE
                     TLRVWVRQHERDTGGGDGGLTSAERQRLKELERENRELRRSNDILRQASAYFGEGGVRP
                     PLEKMMPLLDKLREQYGVGPVCSELHIAPSTYYHCQQQRHHPDKRSARAQHDDWLKKEI
                     QRVYDENHQVYGVRKVWRQLLREGIRVARCTVARLMAVMGLAGVLRGKKVRTTVSRKAV
                     AACDRVNRQFVAERPDQLWVADFTWVSTWQGFVYVAFIIDVFAGYIVGWQVSSSMETTF
                     VLDALEQALWARRPSGTIHHSDKGSQYVSLAYTERLKEAGLLASTGSTGDSYDNAMAES
                     INGLYKAEVIHRKSWKNRAEVELATLTWVDWYNNRRLLGRLGHTPPAEAEKAYYASIGN
                     DDLAA"
                     /name="IS3 family transposase"
     misc_feature    complement(4340..4456)
                     /locus_tag="HVZ77_28865"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01497"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="AL1L pseudoknot; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /db_xref="RFAM:RF01497"
     gene            complement(4981..5262)
                     /locus_tag="HVZ77_28870"
     CDS             complement(4981..5262)
                     /locus_tag="HVZ77_28870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001185482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CopG family transcriptional regulator"
                     /protein_id="QMC48030.1"
                     /translation="MALKLNRPNIDESQQPATNAETARFISGATRAPVVGKPKLMNFRL
                     SAHFEDILEAEAIRTGQSKTTVLKAALAMYNSQDENIKNHWLLESAKF"
                     /name="CopG family transcriptional regulator"
     gene            complement(5360..6022)
                     /locus_tag="HVZ77_28875"
     CDS             complement(5360..6022)
                     /locus_tag="HVZ77_28875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000516401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidyl-arginine deiminase"
                     /protein_id="QMC48031.1"
                     /translation="MGKILLVVSDKGGVGKSTYVANTGSMLVNKGKSVIILKTDKNHDL
                     LSWNEKRTDNGLLTIPVHAAYGNVSNEIKRLSKLCEVLIVDCPGHDSQEFRSALTVSDI
                     VVTLVKPSSDFESETLTSVTEKIRTAQKANAALEPWVLFTRINSAKPRHRKAAIDLDKL
                     LRSDNIWIQPLKTRISELDVYESACNEGAGVHDVSRASSLSTAKAQIELVAQEIGIL"
                     /name="peptidyl-arginine deiminase"
     gene            6403..7047
                     /locus_tag="HVZ77_28880"
     CDS             6403..7047
                     /locus_tag="HVZ77_28880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001503708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="QMC48032.1"
                     /translation="MTSNAPTSFVRAYLRASTAEQDASRAQETIEDFARERGLIICSFY
                     IENESGSRLDRPELFRLLRDCQQNDILLIEDVDRLSRLSGEDWNTLKKMIRQKDIRVMA
                     VNVPTTWINSGMSEFDSRLFAAINDMLLDMLAAVARRDYEQRRERQKQGIEKARKDGKY
                     KGRKPNQARHDAIIRLIESGSSWTQVQKVLGCSRGTISSAIKRKTGQKSSK"
                     /name="recombinase family protein"
     gene            complement(7202..7285)
                     /locus_tag="HVZ77_28885"
     CDS             complement(7202..7285)
                     /locus_tag="HVZ77_28885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_001165328.2"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Damage inducible protein"
                     /protein_id="QMC48056.1"
                     /translation="MIDKAIIVLGALISLLELIRYLLQLMG"
                     /name="Damage inducible protein"
     gene            complement(8279..8908)
                     /locus_tag="HVZ77_28890"
     CDS             complement(8279..8908)
                     /locus_tag="HVZ77_28890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011977833.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QMC48033.1"
                     /translation="MLEQFFDILNKDVLFDLSKTRTPDSSKLIIHEDGELSEIKELEIK
                     EIPDDSIAFTLDFSSKRNVKKNGVLFSQLSPYFDKGNGDGVNKSCDLVLISRNGDKFTI
                     LIFDQKSKKPDIDSSFIQLENSRLFISYMVDIISLFYDVNVNKDDITFKRVIGTTRVVK
                     TGVNAATSQQEILRRKKLRELGMKEVSIKRTASPEKGWLDYRGIVL"
                     /name="hypothetical protein"
     gene            complement(8910..10361)
                     /locus_tag="HVZ77_28895"
     CDS             complement(8910..10361)
                     /locus_tag="HVZ77_28895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011977832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="QMC48034.1"
                     /translation="MEIEFENIGFIKSGKIETNNITIIFGPNNVGKTYLSYSTYAAISK
                     YNAILKGKIKIPDSVSSDLVLNGVAKYDIANVFTDGFIKSVNDELSSKLPAFFKDSSEM
                     FKNSKIRVIDSHIKDRVVNAEVNINVSISENIILNIKKEKNSTSIIFSVASSKNNNEAG
                     KYVVNLKEKDASDHLNILFNFFFVREILDSAANGTFIITSERTGISLFQKEIDGNRSNI
                     VDSYIWNRLSGLSSSDFVWAFDDIMNKKVAKFSEPINHNINIIRNFSGLNEKTAFMTTT
                     ANRGRRSPRKSAELADIIRTLESLTGGQYSPSDGDTIFTASCGNGDKVSMPLSMSSASN
                     KALFLLDIYIRYYLSNDSYLIIDEPELNLHPHNQIKMAELLVRLSNYGVKIIITTHSDY
                     IVKEINNRIMASQLKDRAQLDEFGYKKSDVIKPSEVNGFTIDNDGIIREVKGNKYGVNA
                     FIFDNAISDIENRTERLYTYLEGDL"
                     /name="AAA family ATPase"
     gene            complement(11543..12289)
                     /locus_tag="HVZ77_28900"
     CDS             complement(11543..12289)
                     /locus_tag="HVZ77_28900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001775081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="QMC48035.1"
                     /translation="MSAISLLEQAAKKELNYREFLCMALQQEWNGRHQRGMESRLKQAR
                     LPWVKTLEQFDFTFQPGIDRKVVRELAGLAFVERSENVILLGPPGVGKTHLAIAPGVKA
                     VDAGHRVLFMPLDRQIATLMKAKQENRLERQLQQLSYARVLILDEIGYLPMNREEASLF
                     FRLLNRRYEKASIILTSNKGFADWGEMFGDHVLATAILDRLLHHSTTLNIKGESYRLKE
                     KRKAGVLTKNTTPISDDEMVKSGQHQ"
                     /name="ATP-binding protein"
     gene            12708..12944
                     /locus_tag="HVZ77_28905"
     CDS             12708..12944
                     /locus_tag="HVZ77_28905"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QMC48036.1"
                     /translation="MTAIKSNSKHTKGMSSSDEDNRKLFNLRQPNACGNNPKAVIGGTI
                     MLPLLNTFMNAPLLSQGATILFLGLLILALKKQ"
                     /name="hypothetical protein"
     gene            complement(13041..13490)
                     /locus_tag="HVZ77_28910"
     CDS             complement(13041..13490)
                     /locus_tag="HVZ77_28910"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000238252.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QMC48037.1"
                     /translation="MVKFPGEVMSSSAAVTVITGVLVFVGGQLIVKSAIEPYIEFKKQL
                     GKISNLLLANQAKLANPCAVEMSEIIHELKDAAAQLMSKHSALPFYIKKFHIGFRFVPS
                     TPEIISSAQKLNLIASIHEGKSKESTYEHMAEIGRMLKIPTTYSL"
                     /name="hypothetical protein"
     gene            13635..14411
                     /locus_tag="HVZ77_28915"
     CDS             13635..14411
                     /locus_tag="HVZ77_28915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QMC48038.1"
                     /translation="MELDTEFRYPNVIDFFGTTLFHLCHFTTIDLHNYAAYNKYAENNI
                     AKSNKRICEEIEQRIKESDKKYHEDIIDSYHQEMQEFGDIYPPMHRKSMVITLYNFCEH
                     QIKTLCLEINKLLPEDMCVKYKLKDDICIKKYRKFLRREAGFDIHPSAELWNLWENMLK
                     VEQIRHVLVHSEGEIEKHRAERLADIKSYCNKKENIRLNKHKIIIDEGYVAGLITELIS
                     LFELLDRQVNLFIRRYESKHGSYEVPLPQEASRTAL"
                     /name="hypothetical protein"
     gene            14470..14922
                     /locus_tag="HVZ77_28920"
     CDS             14470..14922
                     /locus_tag="HVZ77_28920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000374058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QMC48039.1"
                     /translation="MDRIEYLKWLMDESPSTTQQLMAWLQRAKCYTPEMKEHRDGVQIE
                     ENGIIVGLRQRTNLYNGDCLTIHVVQLPEKIQNKGWFKSFLKLCCESNPWNDVVIEDVK
                     NPYLLAFCQKHKFKVLADFYPDTYIVNSEEIMALEIPPLKRYEDYL"
                     /name="hypothetical protein"
     gene            complement(14994..15173)
                     /locus_tag="HVZ77_28925"
     CDS             complement(14994..15173)
                     /locus_tag="HVZ77_28925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000347020.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QMC48040.1"
                     /translation="MDFMSILGRCLLLPFPVAMFVGCLFPGIDDRFTGMFMSFIVGCLS
                     WYITKPKPQKAEVA"
                     /name="hypothetical protein"
     gene            16163..16513
                     /locus_tag="HVZ77_28930"
                     /pseudo=""
     CDS             16163..16513
                     /locus_tag="HVZ77_28930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000156234.1"
                     /note="incomplete; partial on complete genome; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            16566..17779
                     /locus_tag="HVZ77_28935"
     CDS             join(16566..16857,16857..17779)
                     /locus_tag="HVZ77_28935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558238.1"
                     /ribosomal_slippage=""
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="QMC48041.1"
                     /translation="MTKNTRFSPEVRQRAIRMVLESQDEYDSQWAAICSIAPKIGCTPE
                     TLRVWVRQHERDTGGGDGGLTSAERQRLKELERENRELRRSNDILRQASAYFGEGGVRP
                     PLEKMMPLLDKLREQYGVGPVCSELHIAPSTYYHCQQQRHHPDKRSARAQHDDWLKKEI
                     QRVYDENHQVYGVRKVWRQLLREGIRVARCTVARLMAVMGLAGVLRGKKVRTTVSRKAV
                     AAGDRVNRQFVAERPDQLWVADFTYVSTWQGFVYVAFIIDVFAGYIVGWRVSSSMETTF
                     VLDALEQALWARRPSGTIHHSDKGSQYVSLAYTERLKEAGLLASTGSTGDSYDNAMAES
                     INGLYKAEVIHRKSWKNRAEVELATLTWVDWYNNRRLLGRLGHTPPAEAEKAYYASIGN
                     DDLAA"
                     /name="IS3 family transposase"
     misc_feature    16847..16963
                     /locus_tag="HVZ77_28935"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01497"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="AL1L pseudoknot; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /db_xref="RFAM:RF01497"
     gene            complement(17823..18182)
                     /locus_tag="HVZ77_28940"
                     /pseudo=""
     CDS             complement(17823..18182)
                     /locus_tag="HVZ77_28940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247738.1"
                     /note="incomplete; partial on complete genome; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="VirB3 family type IV secretion system protein"
                     /name="VirB3 family type IV secretion system protein"
     gene            complement(18201..18497)
                     /locus_tag="HVZ77_28945"
     CDS             complement(18201..18497)
                     /locus_tag="HVZ77_28945"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000916185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TrbC/VirB2 family protein"
                     /protein_id="QMC48042.1"
                     /translation="MLKLNLNKRYLTLSLFMAALMLCVAEPAFADDVSTKTTGFLQKII
                     DFLTDIRKPAITIIALVIGYIAIFSRQHTSWIVPLVIGIIIFIVAPYIPDWLA"
                     /name="TrbC/VirB2 family protein"
     gene            complement(18475..19122)
                     /locus_tag="HVZ77_28950"
     CDS             complement(18475..19122)
                     /locus_tag="HVZ77_28950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000953524.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lytic transglycosylase domain-containing protein"
                     /protein_id="QMC48043.1"
                     /translation="MLSTSTFLALAMQCAASVHPDTTHEVARVESGFNPYAIAEIIPKV
                     KRKPGNKGVVSYFPESKEAALKIVKNIELRNHRYSVGLMQITSTNFAKFGTTAEKMFDP
                     CENLKVSEKILVDCYKRGGDLVRGLSCYYSGNPETGVKPEPEFNNTSYVQRIGFSPPDN
                     KKSFIVPSVKEMIKKENKTTITPEEIIIYPQYAMRGTVSNEKETKDVEIKSE"
                     /name="lytic transglycosylase domain-containing protein"
     gene            complement(19296..19814)
                     /locus_tag="HVZ77_28955"
     CDS             complement(19296..19814)
                     /locus_tag="HVZ77_28955"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001714230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription termination factor NusG"
                     /protein_id="QMC48044.1"
                     /translation="MKGQKQFYLLQCSPHFHQSVLLQLSRSGIAYYNPVIRTFYKRRDC
                     SAYRGQIMPMFPGYVFVLLDFEVVHPSRFTRMKNVYGLVSFGEYPAEVPLSVINEVKEQ
                     EKIFSMNLSLMNNSCLAKILLLAEASKRGQVFADYVCNKKYDRLKNDSYKRKAETATQC
                     TLPSYRSSC"
                     /name="transcription termination factor NusG"
     gene            complement(20167..21333)
                     /locus_tag="HVZ77_28960"
     CDS             complement(20167..21333)
                     /locus_tag="HVZ77_28960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001694629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="relaxase/mobilization nuclease domain-containing
                     protein"
                     /protein_id="QMC48045.1"
                     /translation="MGVYVDKEYRVKRKSSENGRKSAFAHKVKNGGKNYSRNVQERINR
                     KGASKEVVVKISGGAVTRQGIRNSIDYMSRESELPVMSESGRVWTGDEILEAKEHMIDR
                     ANDPQHVMNDKGKENKKITQNIVFSPPVSAKVKPEDLLESVRKTMQKKYPNHRFVLGYH
                     CDKKEHPHVHVVFRIRDNDGKRADIRKKDLREIRTGFCEELKLKGYDVKATHKQQHGLN
                     QSVKDAHNTAPKRQKGVYEVVDVGYDHYQNDKTKSKQHFIKLKTLNKGVEKTYWGADFG
                     DLCSRENVKAGDLVRLKKLGQKEVKIPALDKNGVQHGWKTVHRNEWQLENLGVKGVDRT
                     PSASKELVLNSPDMLLKQQQRMAQFTQQKASTLQSEQKLKTGIKFWGL"
                     /name="relaxase/mobilization nuclease domain-containing
                     protein"
     gene            complement(21336..21881)
                     /locus_tag="HVZ77_28965"
     CDS             complement(21336..21881)
                     /locus_tag="HVZ77_28965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000757693.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA distortion polypeptide 1"
                     /protein_id="QMC48057.1"
                     /translation="MKKVQFRIDENQHDDLLDCLKTLYPDEPALTVAKGMKLLANALLK
                     SKAGSKDINTFFDNNDFIKTTMYLTGKQRADIERAANRHGWTLSRECRYRIQTTLENEL
                     DFFDQELLMMNRCRNSIDKIGRNFHYIIVNDQTRVLDKDGFYQDVERLTKEIFNLKNQF
                     ENYIMLCKGRTVSNKVEM"
                     /name="DNA distortion polypeptide 1"
     gene            complement(21876..21950)
                     /locus_tag="HVZ77_28970"
                     /pseudo=""
     CDS             complement(21876..21950)
                     /locus_tag="HVZ77_28970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000202958.1"
                     /note="incomplete; partial on complete genome; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DNA distortion polypeptide 3"
                     /name="DNA distortion polypeptide 3"
     gene            complement(22207..22479)
                     /locus_tag="HVZ77_28975"
     CDS             complement(22207..22479)
                     /locus_tag="HVZ77_28975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001547192.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QMC48046.1"
                     /translation="MTKHDFVSFVSGELRQGAVRFSLAFNSKGEIVLHWTNKAGIRVWR
                     ILSGNRGKKPSKANLERMSNFRRWLFDARQGMEGYTQQPEQSNLS"
                     /name="hypothetical protein"
     gene            complement(22492..22641)
                     /locus_tag="HVZ77_28980"
     CDS             complement(22492..22641)
                     /locus_tag="HVZ77_28980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000003880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QMC48047.1"
                     /translation="MSERILSAINDVEKGGRPVFPLMPFHVFPEYMALLRKALEKKTQK
                     RTDK"
                     /name="hypothetical protein"
     gene            complement(22711..22890)
                     /locus_tag="HVZ77_28985"
     CDS             complement(22711..22890)
                     /locus_tag="HVZ77_28985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000439078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QMC48048.1"
                     /translation="MEREFSAKASLNRNIKFWFEQCGLSKERVIRCIDNWYDLAYPPSE
                     QEKAKKEAIEKLIK"
                     /name="hypothetical protein"
     gene            22977..24089
                     /locus_tag="HVZ77_28990"
     CDS             22977..24089
                     /locus_tag="HVZ77_28990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_414557.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS4-like element IS421 family transposase"
                     /protein_id="QMC48049.1"
                     /translation="MNYSHDNWSAILAHIGKPEELDTSARNAGALTRRREIRDAATLLR
                     LGLAYGPGGMSLREVTAWAQLHDVATLSDVALLKRLRNAADWFGILAAQTLAVRAAVTG
                     CTSGKRLRLVDGTAISAPGGGSAEWRLHMGYDPHTCQFTDFELTDSRDAERLDRFAQTA
                     DEIRIADRGFGSRPECIRSLAFGEADYIVRVHWRGLRWLTAEGMRFDMMGFLRGLDCGK
                     NGETTVMIGNSGNKKAGAPFPARLIAVSLPPEKALISKTRLLSENRRKGRVVQAETLEA
                     AGHVLLLTSLPEDEYSAEQVADCYRLRWQIELAFKRLKSLLHLDALRAKEPELAKAWIF
                     ANLLAAFLIDDIIQPSLDFPPRSAGSEKKN"
                     /name="IS4-like element IS421 family transposase"
     gene            complement(24283..24612)
                     /locus_tag="HVZ77_28995"
     CDS             complement(24283..24612)
                     /locus_tag="HVZ77_28995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000866645.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QMC48050.1"
                     /translation="MKVLTFKNDTVSVGDVFVSSWGYEQTNVTFYQVLSVHGKKTVTVR
                     EIRANSEYTHSMVGFKTPVLNDFTGECLKRQIKDFGDELAIKIEDFETAYKTLPEEKHR
                     FSSYY"
                     /name="hypothetical protein"
     gene            complement(24705..24920)
                     /locus_tag="HVZ77_29000"
     CDS             complement(24705..24920)
                     /locus_tag="HVZ77_29000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001180116.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QMC48051.1"
                     /translation="MQNKPTPEEVKNARVAAGLTLKEAADIFGYQLNSWQMKESAGKAS
                     RSLSVGEYQYLLLLANMHPSYRLVKK"
                     /name="hypothetical protein"
     gene            complement(24910..25155)
                     /locus_tag="HVZ77_29005"
     CDS             complement(24910..25155)
                     /locus_tag="HVZ77_29005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001550454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QMC48052.1"
                     /translation="MNKDKIIKKNRGNYSYVIRTMDEDGDAVFHVLKYVKTIDKTKNRK
                     TVRKLIMDEKLNLASLMLLDNGILCDCLTKGDENAE"
                     /name="hypothetical protein"
     gene            complement(25203..25526)
                     /locus_tag="HVZ77_29010"
     CDS             complement(25203..25526)
                     /locus_tag="HVZ77_29010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QMC48053.1"
                     /translation="MQNYAKSVATEILRQLGGNRFIVMTGAKSFSYFDENGECGLTFRL
                     PSNFAMKGINLVKIKLDFTDTYQVKFSRVRGDEVKDISRFDNIYCDQLACLFTQETGLH
                     TVL"
                     /name="hypothetical protein"
     gene            complement(25671..25952)
                     /locus_tag="HVZ77_29015"
     CDS             complement(25671..25952)
                     /locus_tag="HVZ77_29015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001694627.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="QMC48054.1"
                     /translation="MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLH
                     GHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGRRESSEVYQIADLR"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(25942..26193)
                     /locus_tag="HVZ77_29020"
     CDS             complement(25942..26193)
                     /locus_tag="HVZ77_29020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000121741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid stabilization protein"
                     /protein_id="QMC48055.1"
                     /translation="MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCV
                     PPKLYAYYRELAEDAELNAVADERMKNPEIVKVNLDDL"
                     /name="plasmid stabilization protein"
     Typing          26562..27151
                     /name="MOBP"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="98.985"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          1731..2176
                     /name="IncX1"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.302"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(20171..21333)
                     /name="MOBP"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="98.969"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 atgaggtttc aggtgagaac tgtaacaggg ttaacgaaag tcaggcatag aaatgaggtt
       61 ggcgttactc tggcatctct ttctctttca gcgaaaagag tcttgtttct tgcactttgt
      121 cagattgact caaaagaaat gttgaatgat gaaattttag aagttgatgc cgatcttttt
      181 tctaaaacaa ccactttgga taagtacgcc gcatatgcag cattaaaaga aggtgcaaaa
      241 gttctggctt caacaacatt agtgttgaat agagatgatt taaaaaatct atctaatgaa
      301 ctgggtatcg ctacatctaa aaataagatg cctgacagac tggatttaaa cttaactgaa
      361 ttctgtgctt attatgatca tctggcaata gttcgcatta agttcactaa tacagcgaaa
      421 cgatattttt caaaacttat tggttctgaa aatagatata ccacacaggt gttaaaatct
      481 gttgttatat tgaacagtgt aaactccaca aacttgtatc aggttatcag aaaatactat
      541 agcttaaatc ctgcgagtaa atccttcgaa atttcagttg atcaacttaa agacgaaatg
      601 ggactttatc atattgaaaa tggtgagaag gtatacaaat atccaaagta ctcttttttt
      661 attcgtgatg ttataaataa aagtataaag gaaataatag aaaaaacaga gataaaaact
      721 ataaagttta ccgttgtagg aaaaaaaggg cgtatggttc acatgttaaa atttgaatat
      781 tctcttaatg aagacacgtc tatttctgat gaagatgcta aattcttgga gaagtttgat
      841 aaggtaattt catataaaca gaaaggataa tattatggaa caaataaaac tacacaaaga
      901 tagtaatgtt tcaataatcg ttattccaaa tcatttactc aaaaataccg gatgggatga
      961 tggtacgtta ttggatgtgg taaaatcaga taatgcactt catattagaa gaaaggaaga
     1021 cgtcgtagac ttagtcacta aaccttgcgt ggatatttta accgctacgt ttaaaaatat
     1081 taaacctgga aaaattataa agtataatag caagctgaat gaaagtctta ataagctcca
     1141 cgtctcagca aggagagtct tttttatttg tttgtatctt tattttaatg gtaggtataa
     1201 ctcagatggg tctattttaa tcagagctga taagtatgct gaatttattg gtatagatcg
     1261 cacaatggca tacaaacaga tgaaagacgc agcagattat ttttcttcca atataaaatt
     1321 aatatctctt tgtgattata taaaaaatga agggctatta agagtagctc tttctactga
     1381 gacaataaat tttatttctg ctgtagatgg tagaaaatat caaactacag ttgtattgta
     1441 tcagtctgct gtaaaactca gtggtcgata ttcatggaat ttatatcagt tgataaaatc
     1501 tcggctatta gataaatccg gtgcttttag cattaaactg gatgaattaa tgattgaatt
     1561 gaactctaga gtaaatttgg aatttaaaga ttataaaaaa tcagttattg gtcggtctat
     1621 agacgaaatt gtagaaaaaa cagaaattaa aagtattaaa tgcgttaatg ctgagaggca
     1681 gggtagaaga gtcagcaaag tccgttttga gatcgaaatg aggtaactca tggctaaaat
     1741 ctatcaattc ccccaggggg aagaacgtgc taaattcagg aaagaaatag ccagggagcg
     1801 taagaaacgt tttgcagtga aaacagggag cacttttgtt aagtggcttg gctggggatg
     1861 gttttatctt cgtcttcttg ccgcgagtgt tttacatttt atctttgttt ttgtgttagc
     1921 cattcttggt gcgtttaaat gggcagtgtt ctggctgggt ggtattttgt gtgtcatcac
     1981 ctggtatcat cttgatcacc agttatggac gccacaaaat ctgactatac cggtgattac
     2041 ggcaacctgg atttttggtc tgttggctga accgctgatg gagctgctca acaaaaccat
     2101 gccctggcac aagttactgg tccccgaacc tgcgggcgaa agcatagaga acagcagcga
     2161 gacgagccag taatgacgct acttagtcgt tatgccagct cctgcctttt cactgcgatg
     2221 caggataggg caaacgccgc aaaatgacgt ctctgacgcc attccgcaac gtttgcccgg
     2281 tgacctacag tcggttcttg ttggagaatt ttatgaaata tcaggtgaga gagtttatta
     2341 acgaaaaata tgctaaggct gttaatattt taaatgataa tcttaaagaa aacttccatg
     2401 ttttttatgg agtaagatta agtgagattc tttttccttc cagtgagtat ggctctgatg
     2461 cattctttaa agagtttgaa tcaattaaca gtgtaatact tccattagta atatttgatt
     2521 ttatagaccg aaagccgatt atggttatcg gcttcgataa gatacctgat gccagtttgt
     2581 tggaaggaac aaatattgtg gttcttgaat gtactaccct cgccgatctt ctgacaaatg
     2641 ataacattgg ttttttatat aaaagctaag aatctcctct cagtttatat tttctgcttg
     2701 ggttgccaag tgttatcgag tctagttcat gcgagtaatg atgtgtatga taatgtgctg
     2761 gatttttcag ataatcaggg agtgatatta tttttccgta gctaattgca gaataaaacc
     2821 agttgcgaaa tgtctcgctg cttgttttta aagcatcttt gggaataaat gctaatttta
     2881 tgttagaaac gtaattaaca ggtttaagtg tggtatgtct gttttgtcca aagtctttta
     2941 aagcatctgt aaattcatat tctgatgtat aattttccgt cttattacta ggttgtttta
     3001 tctggaatat gaatgaatag tagttctggc caagtatttc aacggtgttt gaatttatgc
     3061 tcagttgttc aataaccgct tctcttttat actctaatct gtctctgaca gattgatata
     3121 caaccattgc tgcatgatgt gaaccaccac tgtttaaagc tacatatcgg tcaagccagg
     3181 agtaatattt aacattaata ggatcgcgag agttgaaacc ttcatgctca atgtgccata
     3241 tattatcctc ccagtctgaa atgttttcag ctttcaggtt tttggctgga tacatcccct
     3301 ccccccacga ataaagatct ttgaaccaac taccatttat taccttgctc catccacaac
     3361 cgaaactttt cgagtcagtc agagattgta ttttgttaaa atcgaagtct agagagtgtt
     3421 tattatctgt agttattaag ttgctcagaa tttcagctag atccctgtca atatatctca
     3481 gtgaaccgcc ccgggtttcc tggagagtgt tttatctgtg aactcaggct gccagatcat
     3541 cgtttccgat ggaagcataa taagcttttt ctgcttctgc cggaggagta tggcccagcc
     3601 ttcccagcaa tcgtcgattg ttataccagt ccacccacgt tagtgtggcc agttccactt
     3661 ctgcacggtt tttccagctc ttacggtgta ttacctccgc tttgtaaaga ccattgatgc
     3721 tctcagccat cgcgttgtca tacgagtcgc ctgtactccc tgttgatgcc agtaatccgg
     3781 cttcttttag tcgctccgta taggccagtg acacatactg agaaccttta tcactgtgat
     3841 ggattgtgcc ggacggccga cgggcccaca acgcctgctc cagtgcatcc agcacgaatg
     3901 ttgtttccat ggatgatgag acctgccatc ccacgatgta tccggcgaac acatcaatga
     3961 tgaacgccac ataaacgaag ccctgccatg tgcttaccca ggtaaaatca gccacccaca
     4021 actggtctgg acgttctgcc acgaactgac ggtttacgcg gtcgcatgcg gcaacggctt
     4081 tccggctgac ggtagtgcgg acctttttcc cccggagaac accggcaagt cccataactg
     4141 ccatgagacg tgccacagtg catctggcca ctctgatacc ttcccgtaac aactgacgcc
     4201 agactttacg cacaccgtat acctggtgat tttcatcgta tacgcgctgt atctctttct
     4261 tcagccagtc atcgtgctgc gcacgggcac tgcgtttatc cggatgatgt cgctgttgct
     4321 gacaatggta atacgttgac ggggcaatat gcagttcgct acataccggt ccgaccccgt
     4381 actgctcacg cagcttatcc agcagtggca tcattttttc cagaggcggt cgaactccgc
     4441 cttcgcaaaa taagcggaag cctggcgaag gatatcgtta ctgcggcgca gttcacgatt
     4501 ttcacgttcc agctctttca gacgctgacg ttcagcgctg gtgagcccac catcaccgcc
     4561 cccggtatcc cgctcatgct ggcgaaccca gacacgcaga gtctccggcg tacagccaat
     4621 ctttggggca atggaacaaa ttgccgccca ctgtgagtca tattcatcct gactttccag
     4681 aaccatacga atcgcccgct gacggacttc gggggaaaaa cgagtatttt tagtcatcct
     4741 gtttacctct ttctcaggga gtttagtctc caggatttcc ggggcggttc acagtgagta
     4801 ttcgctaaat atattttcaa gctgcaatat ggtgtctgca tctgctgtag gtttaaataa
     4861 cttaatatca gcaagatttt taaacgttgc tgtggtcagt ttatggtgat ctgtcaacct
     4921 gtagagttta cagattaatt cggttaaata tctcatagat tttcatccat gcttctatgg
     4981 ttagaatttt gcagactcaa gcaaccagtg attctttatg ttttcatcct ggctgttgta
     5041 catcgccagc gctgctttga gaacggttgt tttgctctgc cctgttctga tagcttcagc
     5101 ttccagtatg tcctcaaaat gggctgaaag tctgaagttc atcaactttg gtttacccac
     5161 tacaggcgct ctggtagcgc cggagataaa acgcgcggtt tctgcgtttg ttgctggttg
     5221 ctgagattca tcgatgttcg gacggtttag ttttaaagcc atgacaattt ccccttgtac
     5281 ggtatgcatt aatagtaaat atcatgctgt ctttacatta tctttataat ataaagattt
     5341 atagatggta ttgatattac tataaaattc caatttcctg tgccacaagt tcaatctgtg
     5401 ctttcgctgt tgaaaggctt gatgcccggc taacgtcatg tacccctgcc ccttcattac
     5461 aggcgctttc atacacatcc agctcggata tccgggtttt aagaggttga atccagatgt
     5521 tgtccgaccg cagtaattta tccagatcaa tggccgcttt tctgtggcgg ggttttgctg
     5581 agttgattct ggtgaacagc acccacggtt ccagggctgc gttagctttc tgagcggtgc
     5641 ggattttctc tgtaacactg gtcagtgttt cgctttcgaa atcagaggac ggcttaacca
     5701 gtgttaccac gatatctgat actgtcaggg cgctacggaa ctcctggctg tcgtggccgg
     5761 gacaatcgac aatgaggact tcacacagct tactaagtcg cttaatttca ttgctgacgt
     5821 ttccgtaagc tgcgtgaacc gggatagtga gtaagccgtt atctgtccgc ttttcgttcc
     5881 agctcaacag atcgtggttt ttatctgtct tgaggataat taccgactta cctttattga
     5941 ccagcattga gcctgtgtta gccacgtagg tactttttcc tacaccaccc ttatctgata
     6001 cgacaagcaa gattttaccc atttgagaat tcctctcttt ataatgtaaa gattatgtaa
     6061 agaccgtctt atctttacat tgtgtgtttt ccgtaaagat gattttgtct ttacagtgtc
     6121 tttatattac atgggattta ccatgtaaag cacaaataaa gacaatcatg tatttatgtt
     6181 gtctttattt tgtaaagact aatgtatatt tacattggct ttacatggta aatcaacact
     6241 tgtctttaca tcatctttat gttgtaaatt cccatgtgac attgtcactt tatgaccaga
     6301 ggtctgtttt ctggttcttt tagagtgtgc ctttcctatc gatccacttt ctggtgcatt
     6361 ttgggtatag tggtgtgacc ttatgcgaac tggttctgta atatgacttc aaatgcacca
     6421 acaagctttg tccgcgctta tctgagagct tcaacagcag aacaggatgc ttcgcgtgcc
     6481 caggaaacta tcgaggattt tgccagggaa agaggcctga tcatttgcag tttttatatt
     6541 gagaatgaat ccggctcccg tcttgaccgc ccagaactct tccgtcttct gagagattgc
     6601 cagcaaaatg acattttgct tatcgaggat gtggacagac tttcccgcct gtcaggggaa
     6661 gactggaata ctctgaagaa aatgattcgg cagaaagaca tccgggttat ggcggtgaat
     6721 gtgccgacga cctggattaa ttctggtatg agtgagtttg acagccggtt gtttgctgcc
     6781 attaacgata tgctgctgga tatgctggcc gctgttgcca gaagggacta tgaacaacgc
     6841 cgggaacgcc agaaacaagg gatagagaaa gcaaggaaag acggcaaata taaagggcgt
     6901 aaacctaatc aagccagaca tgatgcaatt atcaggttga tagaaagcgg tagctcctgg
     6961 acacaggtac agaaagtgct agggtgcagc cgcggcacaa taagcagtgc gataaaacgt
     7021 aaaaccgggc agaaatccag taagtagagg ggaggggggt taatatatct gaaaggcagg
     7081 atattaactc aggaggttgg gggtgtggtg tttagtcaat gcatttgaat gttgtaacta
     7141 gaatatagtt ttattaaagg ccggaggtgg ttagcccccg gccttagtta cgtctctgcc
     7201 atcagcccat caactggaga aggtagcgaa tcagttcaag aagcgagatt agcgctccca
     7261 gaacgatgat tgctttatca atcatccgtt tactccatta tatggagcag actcccgata
     7321 cttactctta cactgcctgt catatcggtt gttcttcgat gttggttgaa gacagttcca
     7381 ctccagccag agcactgaca acagcaccac ctgtttttca gccaggactt aaaatcgctt
     7441 aatccttgcg ggaaggctgg agttataacg gatcagaacc aaccggcgta ttatacgcat
     7501 aagcggatac ggttgcattc catatcatgt agacatatta tgtctatgtt ggttgaagag
     7561 agttcttctc cagtcagagc caccaactca aggctggaaa aaacaaaaaa gcccgattac
     7621 cagtcgggtt tttttgtgcc tgtcgttcgg ctgtacttcc gttttttccc cttcatttga
     7681 gggatttttc tttcattttt tgttgcggcc aatactgctg atcgcgttgg ccaacagaac
     7741 aatgccgtta ccggcattat catgaatccc gttttttcag taagttgcag catacaaagt
     7801 aattaaaaaa acgtcatttt ttgttgatgg atgcagtagc ggtggtgcgc tacgtgaaat
     7861 ctggaaaatg ctggcgggta agtgactcaa tttttaatct ccgcacatgt tttttggacg
     7921 tgccagcaat tatgacctga agcagaggtg cgtccgacaa caaaaattcc gatcaccaaa
     7981 aaaattttgg acattttttc cgataatgca tttttgtcca gggggatatg aacgacaggg
     8041 caggacgaaa tctggaagtt atcctgaatt acccaggata tgggcgcgta tgccggagta
     8101 gagcaccaga taaaggaaat gaattcagtg tatgttgtaa ctaataaggt ctggacagaa
     8161 acacctgaat gtccaattat acagaaaatt aaacgaggcc agagacaaat aatctccctg
     8221 aggggaggca tcctgtatct ctggcaggtt cactttcaga gatgaaactt gattatcatc
     8281 acaatactat tcctctataa tctaaccatc ccttttctgg tgatgccgta cgctttatgg
     8341 acacttcttt cataccaagt tcacgaagct tctttcttct caatatttct tgttgagaag
     8401 tagctgcatt aactcccgtt tttacaactc tggtagttcc aattactcgt ttaaaggtta
     8461 tatcatcctt attaacgtta acgtcgtaga ataaagaaat aatatcaacc atataggaaa
     8521 taaaaagcct tgaattttct aactgaataa atgatgaatc tatatcaggc tttttagatt
     8581 tttggtcaaa aataagaata gtgaacttat ctccatttct gcttatcaat acaagatcgc
     8641 atgatttatt tactccatct ccatttccct tatcaaaata tggtgacaat tgagaaaata
     8701 aaacaccatt ctttttaacg tttcttttac tcgaaaagtc caaagtaaat gcaatcgaat
     8761 cgtcaggtat ttcttttatt tccaactctt ttatttcact cagttcacca tcctcatgaa
     8821 taattaattt agaagaatca ggagttctcg tttttgacaa atcaaataaa acatccttat
     8881 ttaaaatatc aaaaaactgc tccaacatat taaagatccc cttctagata tgtatacaaa
     8941 cgttcagttc tgttttctat atcagaaatt gcattatcga aaataaatgc atttacacca
     9001 tatttattcc ctttaacctc cctgataata ccatcattat caatagtaaa accattcact
     9061 tccgatggtt taattacatc tgatttttta tatccaaact catctaattg tgctctatct
     9121 ttcaactgtg aagccattat ccgattgttg atttctttaa caatataatc gctatgagtt
     9181 gttattataa ttttaactcc ataattagaa agccttacaa gcaactcagc cattttaatc
     9241 tgattatgag gatgcaaatt tagctctggt tcatcgatta tcaaataaga gtcattagac
     9301 aagtagtatc taatataaat atccagtaaa aacaaagctt tattagatgc agatgacata
     9361 gacagtggca ttgatacttt atcgccattg ccgcaagacg cagtaaaaat tgtatcacca
     9421 tcagatggag aatattgacc accagtaagt gactcaagag ttcttataat atctgcaagc
     9481 tcagcagact ttctgggtga ccttcgacca cgattcgctg tcgttgtcat gaacgctgtt
     9541 ttttcattta aaccagaaaa attccttatt atatttatat tatgattaat tggttcagaa
     9601 aatttagcca ccttcttatt cataatatcg tcaaaagccc acacaaaatc acttgaagat
     9661 aacccagaaa gcctattcca gatgtaagaa tcaactatat tactcctgtt cccatcaatt
     9721 tccttttgaa atagagaaat accagttcgc tcagatgtaa ttataaatgt gccattcgca
     9781 gcagaatcaa ggatttcacg aacaaaaaag aagttaaaca aaatatttaa atgatctgaa
     9841 gcatcctttt cttttaagtt gacaacatac ttacctgcct cattattatt tttagatgac
     9901 gcaactgaaa aaattatact tgtgctattt ttctcttttt ttatatttaa tattatgttt
     9961 tcactaatag atacgtttat attaacctct gcattgacca ctctgtcctt gatatgagaa
    10021 tcaataacac gaatcttaga gttcttgaac atctctgagc tatctttgaa aaaagctggc
    10081 aactttgatg aaagctcatc attaactgac ttaatgaagc cgtcagtaaa aacattggca
    10141 atatcgtatt tagccactcc atttaaaacc aaatcactag acactgagtc tggtatttta
    10201 atttttcctt ttaaaatagc attatactta ctaatagcag cataggtact atagcttaaa
    10261 tatgttttac caacattatt tggtccaaag ataatagtaa tattattagt ttctatcttc
    10321 ccgcttttta taaacccaat gttttcaaat tctatttcca ttcatatcac ccactaaaat
    10381 gttatgattt gaccctggtt atattcaggt taactatacc tatcatgaca atacactcat
    10441 acatgatagt ttagaaatca ccctcaaatg agtataaatc gcattaaatt taccataacg
    10501 tcgcattgta cgcatcatcc aaaccgcatt aaggatgatc acgacaacag accaggtaaa
    10561 attacctgaa cgtccagtga cgttcataag acaccaccgt tgttgtttaa ctgattgaat
    10621 tataccaagc cagatctgcg gcaaccaaca taaccggacg aaatcacctg aatgtgtaac
    10681 ggcgcgacga taaacaaaaa atgcagtttt aaggctgtta tatagccgtg taaaggcttc
    10741 ctgataaata caatgtagcc aggcaaacgt gtggttatgt tctgccgaga tggatcggca
    10801 attctggagg tgtccatgtt actggtcatt gaactaaatg gagctgagtt agtgtacgat
    10861 aggcttgcct atcgcttact gttcagcagt aaatatatcg ccatagtctg ggcgtactaa
    10921 tcagacgggg actgggcatt gccctttccc ttttcgcgca ctgaacagaa ttacctgaat
    10981 gtccaagtgg ggggattaaa caaggtgcct aaaaaggccg ctggcgcggc cttgatgaca
    11041 ctttatggcg ttgtcggcgg agtccatccg gcacgttttg ctgccaccat ccattgaggg
    11101 gttcctgtcg tgacatgttg ctgacagtaa ctgtatagct gcttgtatac cgttgtcgtt
    11161 gtctggttca accgtacttt ctgactggct tgactcagtt taatggctgt atgttggtct
    11221 tgcatcaggg atgaaattgc cacccgtaga catgatgcta gttgcggatc gacagggggt
    11281 aaatccagaa tggcttgtag cttagtgata tgttctttaa gtgtccttgc gccatccata
    11341 gacgctatta cgtcagcgta cattgtattt tttccttatt caccagtggg atagcctgat
    11401 gatatcaggt cagatcacag ccagccagta gagctggaca gaaaaacctg aacgtccaat
    11461 atggggaaag gattacgtga cggtgtcaac gccacgatgt ttgaccgtta tttgccattt
    11521 tcatgcccgc taaatacttt cgttactgat gctgtccgct tttcaccatt tcatcatcac
    11581 tgattggcgt tgtgtttttg gttagcactc cagctttacg tttctctttt aaccgataac
    11641 tctctccttt gatattcagc gtggttgagt gatgtagcaa ccgatccagt atcgcggttg
    11701 ccagcacgtg atctccgaac atttctcccc agtctgcgaa ccctttgttt gacgtcagta
    11761 tgatgctcgc tttttcatat cgacggttca gtagccggaa gaacaggctg gcttcctctc
    11821 tgttcatcgg cagatagcct atttcatcca ggatcaacac ccgggcataa ctcagttgct
    11881 gtagctgacg ctccagccgg ttttcctgtt tcgctttcat cagtgtcgcg atctgtctgt
    11941 ccagtggcat aaacagtacc cgatgtcccg catccaccgc tttcacgcca ggagctatgg
    12001 ccagatgagt ttttcctaca ccaggaggtc ccagcaggat cacgttttcg ctgcgctcca
    12061 cgaacgccaa accagccagt tcccgaacaa ccttacggtc gatgcccggc tggaaggtaa
    12121 agtcgaactg ctccagcgtt ttgacccacg gcagacgagc ctgcttcagc ctggactcca
    12181 taccgcgctg atgcctgccg ttccattcct gctgtagcgc catgcacagg aactcccggt
    12241 agttcagctc ttttttagct gcctgttcca gcaggcttat cgcagacatt aacctctgca
    12301 atagaatatc tattgcgtga tttattataa atgttatccc tttattgttt tccaattatc
    12361 cccgcagttg aagaaatcag cactgaataa aattttattc atgatgctta caaataaatt
    12421 aatgtagatg aatcatcggg atagagtatt ctacatcaac tgcattctta attttacgtc
    12481 aaaatcaagc gttgcactaa aataaatcct tactagaata gctatccaga agaatcacca
    12541 tgtattcagt ggctgtcttc agtctgaccc tcgggcgcag attcttgttg tgttaaaata
    12601 ttaggaaaat aaatcaggag tgaaaatgca gtgacagaga cacgttacac aacgtctgaa
    12661 agcaaaaaaa agccctgaat aatcagagct ttattactgg attggaaatg acggccatca
    12721 aatccaattc aaaacacacc aaaggcatgt cctcaagtga tgaagataat agaaaactat
    12781 tcaatctacg tcaaccgaat gcctgcggta acaatcccaa agccgttatc ggaggtacga
    12841 ttatgttgcc attgctcaac acgttcatga atgcccctct tctgagtcag ggggctacta
    12901 tcctgtttct tgggcttctt atccttgcgc tcaagaaaca gtgatcgcac tgagctggct
    12961 tcggccagct tctttacttg gatagaatca gctgaatgtc caggtggcgc gtggattatg
    13021 taatctgatc ggcgtgaaga ttaaagagaa taggtggttg ggattttgag catacgtcca
    13081 atctcggcca tgtgctcata tgtactttcc ttgcttttac cttcatgtat tgatgctatc
    13141 aaattcaatt tttgcgccga actaataatt tcaggcgttg atggaacaaa gcggaatcca
    13201 atatggaatt ttttgatata gaaaggcaaa gctgaatgct tcgacattaa ctgagctgcg
    13261 gcatctttca actcatggat gatctcagac atttcaacag cacaaggatt agctaattta
    13321 gcttggttag ctaataacag atttgatatt tttcccaatt gtttcttaaa ttctatataa
    13381 ggttcaatcg cgctctttac aatgagctga ccaccaacaa aaacaagaac accagttata
    13441 acggttacag cagcggacga actcataact tcaccaggaa atttaaccat agaagctatc
    13501 ctaccctgag tgtaacagtc tgtctactgg acagaaaatg ctatacgtcc agtctgtgct
    13561 ggaattatga taaatgctta ctttagagat gcgactggca acagcttaag gctgtcatgc
    13621 gattaaggat gtgtatggaa ctggatactg aatttcgtta ccccaatgtt atagatttct
    13681 tcggtacaac cctgtttcac ctttgtcatt tcacaaccat agatctccat aattacgctg
    13741 catataataa atatgctgag aataacattg cgaaaagtaa taaaagaatt tgtgaagaaa
    13801 ttgaacagcg aataaaggaa agtgataaga aataccacga ggatattatc gatagctacc
    13861 atcaggagat gcaggaattt ggtgatattt atccccctat gcatcgaaag tcaatggtta
    13921 tcactttata taacttttgc gaacatcaga ttaaaacgct gtgcctagaa ataaacaaac
    13981 ttcttccgga agacatgtgt gttaaatata aattaaaaga tgatatatgt attaaaaagt
    14041 atagaaaatt tctgcggcgc gaagctggtt ttgacataca tccaagtgca gaattatgga
    14101 acctatggga aaatatgctg aaagtggaac aaatcaggca tgttctggtt cactccgaag
    14161 gtgagataga gaaacacaga gcggagcggc tggctgatat aaaaagctat tgtaataaga
    14221 aagaaaatat cagactgaac aaacacaaaa ttatcattga tgagggctat gtggcagggc
    14281 ttatcaccga acttatctca ctgtttgagc tactggacag gcaggtgaat ctcttcatcc
    14341 gtagatacga aagcaagcat ggtagctacg aagttccact tccgcaggag gcatcacgaa
    14401 cagccctatg atttgcggga taggaagcca aaaacgctcg taattaattg ttcttattga
    14461 gagatacata tggatcgcat cgaatatttg aaatggctta tggatgaatc accttctacg
    14521 actcagcaac ttatggcatg gctccaaaga gcaaaatgct atacccctga aatgaaagaa
    14581 caccgtgatg gagtacagat cgaagagaat ggtattatcg taggtctgcg gcaaagaacg
    14641 aatctgtata atggggactg cctgactatt catgttgttc aacttcctga aaaaatacag
    14701 aataaaggct ggtttaaatc ttttcttaaa ttatgctgcg aatctaatcc gtggaacgat
    14761 gtagttattg aggatgtaaa aaatccatac cttctggcat tttgtcaaaa gcataaattt
    14821 aaagtcctag ctgattttta tcctgacacc tatatagtta attcagaaga aattatggcg
    14881 ttggagatac ctccacttaa acggtacgaa gattatcttt agtgaatagt ggacagagtt
    14941 acctgaatgt ccaagtgagg tggagaatta aacgaggacg taaaaaaggc cgcttacgcg
    15001 acctcagcct tttgcggttt tggcttggtg atataccacg atagacaacc gacaataaaa
    15061 ctcatgaaca ttccagtaaa acgatcatca atgcctggaa acaggcaacc gacaaacatc
    15121 gcaacaggga aaggaagaag taaacagcgc cccaaaatgc tcataaaatc cataaatcct
    15181 cctttgttaa agggcaggaa gcggttcact tcctgccctt agttacgttt ccgctgtcat
    15241 cagtcgatga actggcgaat cagttccaga attgcaatca gcgcgtttgc aacggcgacc
    15301 acagccctga gaacgatgat taacaaatta atcatccgtt tctccagtaa aactggagga
    15361 aatcaccgtt gcttactcat acactgcctg tcacaacggc tctctcgcat tgttaggtgt
    15421 agagtgacct cctcctgcca gagcaccgaa tacagcacca cctgtttatc cagccaggac
    15481 tttaaaatcg ttcatacccg cagatacggg aagggcagga ttgcaagtca actacatgac
    15541 taactgactg attatacgct acacaaaaca cccgttacac cactaaatgt ggttccttaa
    15601 ccacatttag ttgctttaca gcaccatagt gaataaaatg taaacgttag gtgtagagta
    15661 accttctcca gtcagagcca ccaactcagg gctggaaaac acaaaaaagc ccgattacca
    15721 gtcgggtttt ttttgtgcct gtcgttcggc tgtacttccg ttttttcccc ttcatttgag
    15781 ggatttttct ttcatttttt gttgcggcca atactgctga tcgcgttggc caacagaacg
    15841 atgccgttac cggcattatc atgaatcccg ttttttcagt aagttgcagc atacaaagta
    15901 attaaaaaaa cgtcatttct tgttgatgta tgcagtagcg gtggtgcgct acgtgaaatc
    15961 tgagattttg tcaaaggaat tacacacgag atttcacaaa gaagaggttt atcgcgtagc
    16021 tttaacattg ttaggacgct tttttagcct gttttgaaca gaactatcta tagtaatagg
    16081 acgcactccc acgctatatg ccgtttaact ccaaggaatg gcaatatgat aaaatacgct
    16141 ttctcataaa tgaggacttc taatgacgat tacggcctac tccaaaacgt tcaagcgtga
    16201 acttgatgcc aggcagttga aaaatctttt tgatgaaaat aatgccgatt cagcgctgag
    16261 tttccgggac tttgtaaaag cagatattga atgcccagcc tgcaatgttt ctggtggcca
    16321 ttatgttgta gaagctaaat cgcagtcgaa aggcaatgtt gtaaagcagg ctcattttgc
    16381 atttcgcgac agcatgggaa aagatactca tcttcctttc tgtgattttt acactggttc
    16441 agacaagcta aatgtcgttg ctaacgacgg gcgtgttgat ttcatgcgtt ctggctctga
    16501 agccacgcaa ctgaaccgcc ccggaaatcc tggagactaa actccctgag aaagaggtaa
    16561 acaggatgac taaaaatact cgtttttccc ccgaagtccg tcagcgggcg attcgtatgg
    16621 ttctggaaag tcaggatgaa tatgactcac agtgggcggc aatttgttcc attgccccaa
    16681 agattggctg tacgccggag actctgcgtg tctgggttcg ccagcatgag cgggataccg
    16741 ggggcggtga tggtgggctc accagcgctg aacgtcagcg tctgaaagag ctggaacgtg
    16801 aaaatcgtga actgcgccgc agtaacgata tccttcgcca ggcttccgct tattttgcga
    16861 aggcggagtt cgaccgcctc tggaaaaaat gatgccactg ctggataagc tgcgtgagca
    16921 gtacggggtc ggaccggtat gtagcgaact gcatattgcc ccgtcaacgt attaccattg
    16981 tcagcaacag cgacatcatc cggataaacg cagtgcccgt gcgcagcacg atgactggct
    17041 gaagaaagag atacagcgcg tatacgatga aaatcaccag gtatacggtg tgcgtaaagt
    17101 ctggcgtcag ttgttacggg aaggtatcag agtggccaga tgcactgtgg cacgtctcat
    17161 ggcagttatg ggacttgccg gtgttctccg gggtaaaaag gtccgcacta ccgtcagccg
    17221 gaaagccgtt gccgcaggcg accgcgtaaa ccgtcagttc gtggcagaac gacctgacca
    17281 gctgtgggtg gctgatttta cttacgtcag cacatggcag ggcttcgtct atgtggcgtt
    17341 tatcattgat gtgtttgccg gatacatcgt ggggtggcgg gtctcatcgt ctatggaaac
    17401 gacattcgtg ctggatgcgc tggagcaggc gttgtgggcc cgtcgtccgt ctggcaccat
    17461 ccatcacagc gataaaggct ctcagtatgt gtcactggcc tatacggagc gactaaaaga
    17521 agccggatta ctggcatcaa cagggagtac aggcgactcg tatgacaacg cgatggctga
    17581 gagcatcaat ggtctttaca aagcggaggt aatacaccgt aagagctgga aaaaccgtgc
    17641 agaagtggaa ctggccacac taacgtgggt ggactggtat aacaatcgac gattgctggg
    17701 aaggctgggc catactcctc cggcagaagc agaaaaagct tattatgctt ccatcggaaa
    17761 cgatgatctg gcagcctgag ttcacagata aaacactctc caggaaaccc ggggcggttc
    17821 aaagagtacg gaattaactc ttcaacagaa gactggtctt tcagcttcat aaagttatcc
    17881 acttttgaaa tatcaacttc gttgtactgg ctccccgcgt aatggactgc gctgaatcgc
    17941 ttgtttgata aaggatgccc tttgacaaga gttctcagat acagaaggtc aaaaaagcgt
    18001 tcatcaaact gtgttacacg cctgatggca taccagccag gaagaatgag ggcatacata
    18061 gcctcatgaa tccagacacc aagcagaaca caaataatgc acattccaag aaaggggtag
    18121 agcggaacgc ccagccccct tattaaagca gggcgcgtaa gacctttaaa aagagtactc
    18181 atagtgcgcc catcctttaa ttacgcaagc cagtcaggaa tatatggtgc gacaataaag
    18241 atgataattc cgataacaag tgggactatc catgaggtat gttgacgaga aaatatcgca
    18301 atatacccaa taacaagagc aataattgta attgcaggct tacgaatatc cgttaaaaaa
    18361 tcaattattt tctgtaaaaa accagttgtc ttcgtagaca catcatccgc aaaagcaggt
    18421 tctgcaacac aaagcatcaa cgcagccata aatagagaaa gcgttaaata acgtttattc
    18481 agatttaatt tcaacatctt ttgtttcctt ttcatttgat acagtgccac gcatggcgta
    18541 ttgaggatat ataatgattt cttcaggtgt gatagtcgtc ttattctcct ttttaatcat
    18601 ttcctttaca gaaggaacaa taaaactttt tttattatca ggagggctaa atcctatacg
    18661 ttgtacataa cttgtattat taaattcagg ttctggcttt actcctgttt ctggattgcc
    18721 ggaataatag caactcagcc cacgcactaa gtcgccacct cgtttataac agtcaaccag
    18781 tattttttct gataccttaa gattttcgca tggatcaaac attttctctg ctgttgtacc
    18841 aaactttgca aaattggtac tcgttatttg cataagtcct acagagtaac gatgattccg
    18901 taattcaatg tttttaacga tcttaagtgc tgcctccttt gattcaggaa agtaagatac
    18961 tacgccttta ttaccaggtt tgcgtttaac ctttggtatt atttccgcaa tcgcatatgg
    19021 gttaaaacct gattcaaccc tggcgacttc gtgcgttgtg tcgggatgaa cgctggcagc
    19081 gcattgcatg gcaagcgcaa gaaaagtaga agtagataac ataaatattc cacattcaga
    19141 acaccgggcg ctatcactcg tcaggaatat cagccccatg aataagctct ttcatcgcct
    19201 gagatttgta ttttttaata agatactgaa caaaaccaga atcagagata cgcctccccc
    19261 tcttgaaact tatttcaatt gcaatttttt caacttcaac acgaacttct gtaggaaggt
    19321 agagtacatt gcgttgcggt ttccgctttc cttttatagc tgtcattttt taacctgtcg
    19381 tattttttgt tacacacata gtcggcaaag acttgtccac gctttgaagc ttctgcaagg
    19441 agaagtattt ttgccagaca ggagttattc atcaggctta aattcatcga aaaaatcttc
    19501 tcctgctctt ttacttcatt tatgacactt agaggaactt cagcaggata ttcaccaaaa
    19561 ctgaccagtc cataaacatt tttcatccgg gtaaagcggg atggatgtac aacctcaaaa
    19621 tccagaagaa cgaatacata accgggaaac attggcatga tttgccccct gtatgcacta
    19681 cagtcacgcc tcttatagaa agtgcgtata actggattgt agtaagcgat accgctccgg
    19741 gataactgca acagaaccga ctgatgaaaa tgcggagaac actgaagcag gtaaaactgt
    19801 ttctgtcctt tcatactcaa tccccgatat acagatgtga caaaacacaa gccaaccgtg
    19861 gttgcttgtg agaaatcacg cccctatgaa gagagacttt ttactattgc gcgaagttta
    19921 tactacaagt ggcttatgct aagttcaaca cataaaacag atctttcgat cttgataaat
    19981 caattttact ttcatttatt ccacataaac aacgaaacac agaatattca tcttttgcag
    20041 atctgttttt tagatcgata gatcgaatga tagctaaaac gcagaatttc gatctgtttt
    20101 taaggtgaaa agatgagcaa gcgaactaaa ataaatattt ttctcgcata atcaatacat
    20161 taaatcttat aagccccaaa atttaatccc tgttttcagt ttctgttctg actgtaacgt
    20221 ggatgctttc tgctgcgtaa actgcgccat tcgctgctgt tgcttcagca gcatatcagg
    20281 gctattcagt accagctctt tgctggccga aggtgttctg tctacgccct taacccccag
    20341 attttctaac tgccactcat ttctgtgaac cgttttccag ccatgctgaa caccgttttt
    20401 atcgagcgcc gggattttta cttctttctg accaagtttc ttaagtctga caagatcacc
    20461 tgctttaacg ttttcccgcg aacataagtc cccaaaatca gccccccagt atgttttctc
    20521 aacccccttg ttaagagtct ttagctttat aaaatgttgc ttagactttg ttttatcgtt
    20581 ctgataatgg tcgtagccaa catcaacaac ctcataaaca cctttctgtc tttttggtgc
    20641 tgtattatgt gcatctttaa cagactgatt aagtccatgc tgttgcttat gggtcgcttt
    20701 aacgtcataa ccttttaact tcaactcttc acaaaaacct gtacgaattt cccgtaaatc
    20761 ttttttcctg atgtcagcgc gtttaccgtc attatctctg atacgaaaaa caacatgaac
    20821 gtgaggatgt tctttcttgt cacagtggta tccaagaaca aaacggtgat taggatattt
    20881 tttctgcatc gttttcctga cagactccag caaatcttca ggctttactt tcgctgaaac
    20941 tggaggcgag aagacaatat tctgtgtaat ttttttattt tctttacctt tatcattcat
    21001 cacatgctga ggatcattag cacgatctat catgtgctct ttagcctcca gaatttcgtc
    21061 acccgtccat acccgaccgc tttcactcat cactggtagc tctgactcac ggctcatata
    21121 atcaatactg ttccgaatcc cctgacgagt aacagcacct ccagatattt tgacaacaac
    21181 ctccttactg gcacccttgc ggttgatacg ttcctgaaca ttgcggctat agttctttcc
    21241 accatttttg actttatgag cgaaagctga cttacgacca ttttctgatg actttcgttt
    21301 aacacgatat tctttatcaa cgtaaacgcc cataatcaca tctccacttt atttgaaaca
    21361 gttctccctt tacataacat aatgtaattc tcaaactgat tcttaagatt aaaaatttct
    21421 tttgtaagac gctccacatc ctgatagaaa ccatctttat caagaaccct ggtctgatca
    21481 ttaacaatga tataatggaa attacgaccg atcttatcaa ttgaattacg gcaacgattc
    21541 atcatcagca gttcctggtc aaagaaatcc agttcatttt caagtgtcgt ctgtatgcgg
    21601 taacgacatt ctcgtgataa cgtccatccg tgacgattag cagctctttc aatatcagcc
    21661 ctttgtttac ctgttaagta catcgttgtt ttgataaaat cattattatc aaaaaacgta
    21721 tttatatcct tactgccagc tttacttttt aataaagcat ttgctaaaag tttcatgcct
    21781 ttagctactg ttaaagctgg ttcatctgga taaagagttt taaggcaatc cagcaaatca
    21841 tcatgctgat tttcatcaat tctgaattga acttttttca taaaaatctc cgacaagaac
    21901 cgactgtagg tcaccgggca aatgttgcgg aatggcgtca gagacgtcat tttgcggcgt
    21961 ttgccctatc ctgcatcgca gtgaatctgg caccgctcat aaattgtgct tgagcatcaa
    22021 caaaaatgca aaaaggctga tgttgtcatg gctgaaaata cgtacgtctg cgaccggaaa
    22081 cccgatcaat gcggtaagga cagtgccatc aggttcgctc cgcgaacggt ctggcaggaa
    22141 gcgcaagcgc agtcctgcgc aatatatcag aaagcacctc ccgaaatacg ggagggcttc
    22201 ggctattcag ctaaggttgc tctgttcagg ttgctgagtg tagccttcca tgccctgacg
    22261 ggcatcaaaa agccagcgcc ggaagttact cattctttca aggttagctt tgcttggttt
    22321 tttgccacga ttaccactta atatccgcca tactcgtatt cctgctttat tagtccagtg
    22381 cagaacaatt tctcctttgc tgttaaaagc aagagaaaag cgtacagcgc cttgccgcaa
    22441 ttctccactg acaaaagaca caaaatcatg ttttgtcata aagcctccgg tttatttatc
    22501 tgttctcttt tgtgtctttt tttccagtgc ttttctgagt aatgccatat actcaggaaa
    22561 gacatggaat ggcatcaaag gaaaaaccgg acgcccaccc ttttcaacgt catttattgc
    22621 tgataatatg cgttccgaca ttttattcct cgcaacagaa tcaagtgtca cggtatcagg
    22681 ttgccccaca acctgatacc atctttatct ttactttatt aacttctcaa ttgcttcttt
    22741 tttggctttc tcctgttctg atggtgggta tgcaaggtca taccagttat caatacaacg
    22801 aataactctt tctttagata acccacattg ttcaaaccaa aattttatat ttcggtttaa
    22861 tgatgctttt gcgctaaact ctctttccat tttcagacct ttactaaaag ggggaatatc
    22921 ccataagcgc taacttaagg gttgtggtat tacgcctgat atgatttaac gtgccgatga
    22981 attactctca cgataactgg tcagcaattc tggcccatat tggtaagccc gaagaactgg
    23041 atacttcggc acgtaatgcc ggggctctaa cccgccgccg cgaaattcgt gatgctgcaa
    23101 ctctgctacg tctggggctg gcttacggcc ccggggggat gtcattacgt gaagtcactg
    23161 catgggctca gctccatgac gttgcaacat tatctgacgt ggctctcctg aagcggctgc
    23221 ggaatgccgc cgactggttt ggcatacttg ccgcacaaac acttgctgta cgcgccgcag
    23281 ttacgggttg tacaagcgga aagagattgc gtcttgtcga tggaacagca atcagtgcgc
    23341 ccgggggcgg cagcgctgaa tggcgactac atatgggata tgatcctcat acctgtcagt
    23401 tcactgattt tgagctaacc gacagcagag acgctgaacg gctggaccga tttgcgcaaa
    23461 cggcagacga gatacgcatt gctgaccggg gattcggttc gcgtcccgaa tgtatccgct
    23521 cacttgcttt tggagaagct gattatatcg tccgggttca ctggcgagga ttgcgctggt
    23581 taactgcaga aggaatgcgc tttgacatga tgggttttct gcgcgggctg gattgcggta
    23641 agaacggtga aaccactgta atgataggca attcaggtaa taaaaaagcc ggagctccct
    23701 ttccggcacg tctcattgcc gtatcacttc ctcccgaaaa agcattaatc agtaaaaccc
    23761 gactgctcag cgagaatcgt cgaaaaggac gagtagttca ggcggaaacg ctggaagcag
    23821 cgggccatgt gctattgcta acatcattac cggaagatga atattcagca gagcaagtgg
    23881 ctgattgtta ccgtctgcga tggcaaattg aactggcttt taagcggctc aaaagtttgc
    23941 tgcacctgga tgctttgcgt gcaaaggaac ctgaactcgc gaaagcgtgg atatttgcta
    24001 atctactcgc cgcattttta attgacgaca taatccagcc atcgctggat ttccccccca
    24061 gaagtgccgg atccgaaaag aagaactaac tcgttgtgga gaataacaaa aatggtcatc
    24121 tggagcttac aggtggccat tcgtgggaca gtatccctga cagcctacaa aacgcaattg
    24181 aagaacgcga ggcatcgtct taacgaggca ccgaggcgtc gcattcttca gatggttcaa
    24241 cccttaagtt agcgcttatg gggaatatcc ccccctgatt aattagtagt aagaagaaaa
    24301 gcgatgtttt tcttccggta gagttttata cgcagtttca aaatcttcga ttttgattgc
    24361 cagctcatca ccaaaatctt ttatctggcg cttaagacat tcaccagtaa aatcatttaa
    24421 aacgggagtt ttaaagccga ccattgaatg ggtatattct gaattggcgc gaatctcgcg
    24481 aacggtgacg gtttttttac cgtgaacaga aagaacctgg tagaaggtta cattggtttg
    24541 ctcatagccc caggatgata caaagacatc accaacagag acagtatcat ttttaaaagt
    24601 taatactttc atttttagct cccgcccagc ttgggctctg gatgaaagag aacctgtttc
    24661 cctttcttgt gttttattat acctgcattt gcaggtatag caagttattt ttttaccagc
    24721 ctgtaagacg gatgcatatt tgctaatagc aataaatact gatattcacc aacagataaa
    24781 gaacgactgg ccttacctgc actttctttc atctgccagg aattcagttg ataaccaaaa
    24841 atatcagcag cttctttaag agtaagacct gccgcaaccc gtgcattctt tacttcttca
    24901 ggtgtaggtt tattctgcat tttcatcccc ttttgtcaga caatcacaca aaatcccatt
    24961 atccagaagc atcaatgatg ccaggttgag tttttcgtcc attatcaatt ttcttactgt
    25021 tttcctgttt ttagttttat caatcgtctt aacatatttt aagacgtgaa aaaccgcatc
    25081 cccatcttca tccatcgttc tgattacata tgagtaatta cctctgtttt tcttaattat
    25141 cttatcttta ttcatattat tcctcataat aactaaaaaa ggggcttaat gccccttttt
    25201 atctataaca cggtatgtaa ccctgtttct tgtgtaaata aacacgctaa ctgatcacaa
    25261 tagatattat cgaatcttga aatatcttta acttcatcac cccgtacacg agaaaatttc
    25321 acctggtacg tatcagtaaa atccagtttg atttttacta agttgatgcc tttcattgca
    25381 aaattggacg gcaaacggaa agttaacccg cactcaccgt tttcatcaaa gtaagaaaaa
    25441 cttttagccc cagtcataac aataaaacga ttaccaccaa gttgacgtaa aatctctgtg
    25501 gctacagact tagcgtagtt ttgcattttt aacctcccgc ccactttggg ctctggatga
    25561 aagagaacct gtttcccttt cttgtgtttt attatacctg catttgcagg tgttgcaaat
    25621 ttttaatgcc atgttctgac tgtaaacagt caatcatttg atgattaatc ttagcgcaaa
    25681 tctgcgatct gataaacttc gctgctttcc cttcttccaa cggcaataac gagtaaaacg
    25741 actttctcat caatgacttg atatacaagt ctgtagccag atgcacgaag tttgatttta
    25801 tagcgatcag catgaccatg taaccgggct gcgggtacgc gtggattttc cagccgttct
    25861 gccagttttt ttttgaattg ttcacggatg gtgtggccga gtttctgcca ttccttcagt
    25921 gctctgcggt caaaagccag ttcataggtc atccaggtta accttcacaa tttccgggtt
    25981 tttcatgcgc tcatcagcaa cagcgtttaa ctcagcatct tcagcgagtt cccgatagta
    26041 ggcgtaaagt tttggtggaa cgcaatagaa cgccggttcg tttcggttca ggatcgcaac
    26101 agcgtcccct tcaccttcag ctacggttcc cataggattt tttttcaggt cagtaatact
    26161 ggccgctgtg gttgtcagaa tttgatagct cataagtcct ccgcttgtct cattggcata
    26221 atagcatctt taaaagcact cttaaaagtg cttttgttga gaaaaacatc agaacaggtg
    26281 agatatggct ctttccgaca tcgccttaaa acgctctgta acgcgttctg agcgtttttt
    26341 cccgtttcgt tatagtcagc tacggtttaa cggtttttaa cgccgctcaa cgctttttag
    26401 cggccttgtt gctgtgatct gttgccatga tccggatagg agttcaatct tgatcaaaat
    26461 ttcctcaagg caacgactgt tttgtaaata ccctctaaaa tgcgctgtat cgcattctga
    26521 gcgatttttt cgatttcgca tggttttcct catggttaca tcgaacaaag cgttagaaag
    26581 cgattcaggg cttctcagtg aaagatccaa aaaggatcaa taaacggatc gtatgatctg
    26641 aactcttctg gttttgagaa aggagacacc gctcgccgca gtcgaacgac cgagcgtagc
    26701 gagttagtga gcgaggaagc ggaacagcac agggataaca ttaggcaatt acgcgcagag
    26761 gttaaaaagc gagcatattg tttttatgtg tggttgtcct ggttcagagt gatctgtcct
    26821 ccgggtttac gcaaagttat ccacaggctc tgtgcattta aaaaacttat cttttcttct
    26881 tgatcttaaa aacttaaaaa cttagagagc cgtaacatca tgaaaaacat aataaaaaaa
    26941 cgctaaagtt gagaggattt ttaacataag ttgagaagat ttttaagtaa ggttgagaag
    27001 atttttaact aaagatgaga ggatttttaa gtaaggttga gaagattttt aactaaagat
    27061 gagaggattt ttaagtgtat ccacagattt aaaaaagatc atgaaaaaca taatgttatg
    27121 aattcatttt gatgtgaata cataaagatc tttatatcta aaggtgataa gctttttaag
    27181 aaaaggttgt agtttgtagt tgatatacaa cctttcaggg gttatcattt agtcaattga
    27241 tatggcttat tctatat
//
