LOCUS       CP052965               22322 bp    DNA     circular BCT 09-FEB-2021
DEFINITION  Staphylococcus epidermidis strain HD40-5 plasmid pHD40-5_2, complete
            sequence.
ACCESSION   CP052965
VERSION     CP052965.1
DBLINK      BioProject: PRJNA546129
            BioSample: SAMN14732900
KEYWORDS    .
SOURCE      Staphylococcus epidermidis
  ORGANISM  Staphylococcus epidermidis
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 22322)
  AUTHORS   Both,A., Huang,J., Qi,M., Lausmann,C., Weisselberg,S., Buttner,H.,
            Lezius,S., Failla,A.V., Christner,M., Stegger,M., Gehrke,T.,
            Baig,S., Citak,M., Alawi,M., Aepfelbacher,M. and Rohde,H.
  TITLE     Distinct clonal lineages and within-host diversification shape
            invasive Staphylococcus epidermidis populations
  JOURNAL   PLoS Pathog 17 (2), e1009304 (2021)
   PUBMED   33544760
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 22322)
  AUTHORS   Both,A., Huang,J., Qi,M., Lausmann,C., Weisselberg,S., Buettner,H.,
            Lezius,S., Failla,A.V., Christner,M., Stegger,M., Gehrke,T.,
            Baig,S., Citak,M., Alawi,M., Aepfelbacher,M. and Rohde,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-APR-2020) Institute of Medical Microbiology, Virology
            and Hygiene, University Medical Center Hamburg-Eppendorf,
            Martinistr. 52, Hamburg, Hamburg 20246, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. v0.4.7
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 402x
            Sequencing Technology             :: Illumina; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/29/2020 13:46:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 2,434
            CDSs (total)                      :: 2,350
            Genes (coding)                    :: 2,289
            CDSs (with protein)               :: 2,289
            Genes (RNA)                       :: 84
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 61
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 61
            CDSs (without protein)            :: 61
            Pseudo Genes (ambiguous residues) :: 0 of 61
            Pseudo Genes (frameshifted)       :: 38 of 61
            Pseudo Genes (incomplete)         :: 24 of 61
            Pseudo Genes (internal stop)      :: 24 of 61
            Pseudo Genes (multiple problems)  :: 21 of 61
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..22322
                     /organism="Staphylococcus epidermidis"
                     /mol_type="genomic DNA"
                     /strain="HD40-5"
                     /isolation_source="nose; prosthetic joint infection"
                     /host="Homo sapiens"
                     /db_xref="taxon:1282"
                     /plasmid="pHD40-5_2"
                     /geo_loc_name="Germany: Hamburg"
                     /lat_lon="53.33 N 10.1 E"
                     /collection_date="2018"
                     /collected_by="Institute of Medical Microbiology, Virology
                     and Hygiene, University Medical Center Hamburg-Eppendorf"
     gene            1..936
                     /locus_tag="HJI04_12025"
     CDS             1..936
                     /locus_tag="HJI04_12025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="QRJ17116.1"
                     /translation="MPNFEKYNLSQVKTERFYQLPKYLFEDAYFKKMSAEAKIMYALLK
                     DRFELSIQNEWVDKNNNIYFIFSNKHLCEYLGYAEQKIIKLKKELISFNLLTQERVGLN
                     KPNRLYLLKPNYDIKASHSKELPNSQFQNNEFGSSRTVNLSGQELPNSQSNDTENNDTD
                     YIKTESNDTNDLNDNKLTFPSNHTNHSNHNNSNFNNEALKFQLLEELPQSIQRYLSNFS
                     VNEIKIIKPVLLKAKTSFNNSIDTYYLLEDMEIEILHVLKRFKAMLIQKNETVEAMQGY
                     LMKSLKSEFAEMHTLNKRRDHLPITSLFNQ"
                     /name="replication initiator protein A"
     gene            2783..3319
                     /locus_tag="HJI04_12030"
     CDS             2783..3319
                     /locus_tag="HJI04_12030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="QRJ17117.1"
                     /translation="MISNKLKSARLAKELTQSEVAKKLYVTRQTVSRWEQGKTLPNIYV
                     IQELSDLYDISLDELVVNTALENKEAKSMKNVNPFALFGAILFNVFLFSLIVIFFGGFL
                     LLSLFISLAMLFSPLILAIFVLTGVQEFNVIQLVMTVIFVVIGLLSIPLLKKVSVFLFK
                     FFKRYLKFNHKAIFY"
                     /name="helix-turn-helix domain-containing protein"
     gene            complement(3485..4447)
                     /locus_tag="HJI04_12035"
     CDS             complement(3485..4447)
                     /locus_tag="HJI04_12035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000336291.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /protein_id="QRJ17118.1"
                     /translation="MCPNSSIYSDEKSRVLVDKTKSGKVRPWREKKIANVDYFELLHIL
                     EFKKAERVKDCAEILEYKQNRETGERKLYRVWFCKSRLCPMCNWRRAMKHGIQSQKVVA
                     EVIKQKPTVRWLFLTLTVKNVYDGEELNKSLSDMAQGFRRMMQYKKINKNLVGFMRATE
                     VTINNKDNSYNQHMHVLVCVEPTYFKNTENYVNQKQWIQFWKKAMKLDYDPNVKVQMIR
                     PKNKYKSDIQSAIDETAKYPVKDTDFMTDDEEKNLKRLSDLEEGLHRKRLISYGGLLKE
                     IHKKLNLDDTEEGDLIHTDDDEKADEDGWFCCKLENHII"
                     /name="protein rep"
     gene            complement(4692..5954)
                     /locus_tag="HJI04_12040"
     CDS             complement(4692..5954)
                     /locus_tag="HJI04_12040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001619005.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid recombination protein"
                     /protein_id="QRJ17134.1"
                     /translation="MSYAVCRMQKVKSAGLKGMQFHNQRERKSRTNDDIDHERTRENYD
                     LKNDKNIDYNERVKEIIESQKTGTRKTRKDAVLVNELLVTSDRDFFEQLDPGEQKRFFE
                     ESYKLFSERYGKQNIAYATVHNDEQTPHMHLGVVPMRDGKLQGKNVFNRQELLWLQDKF
                     PEHMKKQGFELKRGERGSDRKHIETAKFKKQTLEKEIDFLEKNLAVKKDEWTAYSDKVK
                     SDLEVPAKRHMKSVEVPTGEKSMFGLGKEIMKTEKKPTKNVVISERDYKNLVTAARDND
                     RLKQHVRNLMSTDMAREYKKLSKEHGQVKEKYSGLVERFNENVNDYNELLEENKSLKSK
                     ISDLKRDVSLIYESTKEFLKERTDGLKAFKNVFKGFVDKVKDKTAQFQEKHDLEPKKNE
                     FELTHNREVKKERSRDQGMSL"
                     /name="plasmid recombination protein"
     gene            complement(6461..6865)
                     /gene="bleO"
                     /locus_tag="HJI04_12045"
     ARG             complement(6465..6865)
                     /name="bleO"
                     /gene="bleO"
                     /gene_name="bleomycin binding protein"
                     /tool="amrfinderplus"
                     /drug_class="BLEOMYCIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(7082..7852)
                     /gene="aadD1"
                     /locus_tag="HJI04_12050"
     ARG             complement(7086..7852)
                     /name="aadD1"
                     /gene="aadD1"
                     /gene_name="aminoglycoside O-nucleotidyltransferase
                     ANT(4')-Ia"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(8189..8758)
                     /locus_tag="HJI04_12055"
     CDS             complement(8189..8758)
                     /locus_tag="HJI04_12055"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QRJ17121.1"
                     /translation="MKKMLRISIFIIVVSIFIVFKYSYQIEGILEEYPNILKAFVALFT
                     LLTTVISLVIAYKSYDNSVKQQEKDKEEKNKQFEENSDRIINSLKSDLAKYTRKINVFR
                     LGYTNSDVEFSELAKELSIKSNLEEIEKLTSQVRSSKSTELAKMDEVNIVNLHTASDSA
                     LFLFDIYENTSRENDGFCCKLENHII"
                     /name="hypothetical protein"
     gene            complement(9093..9188)
                     /locus_tag="HJI04_12060"
     CDS             complement(9093..9188)
                     /locus_tag="HJI04_12060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002497230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="QRJ17122.1"
                     /translation="MSEIFVNIMTTAASGCLVALFAHWLRKRNDE"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            9599..10978
                     /gene="tet(K)"
                     /locus_tag="HJI04_12065"
     ARG             9600..10975
                     /name="tet(K)"
                     /gene="tet(K)"
                     /gene_name="tetracycline efflux MFS transporter Tet(K)"
                     /tool="amrfinderplus"
                     /drug_class="TETRACYCLINE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            11164..12432
                     /locus_tag="HJI04_12070"
     CDS             11164..12432
                     /locus_tag="HJI04_12070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid recombination protein"
                     /protein_id="QRJ17124.1"
                     /translation="MAYSIIRVAKVKSKTNTKGIQKHVQRQNKNYENMDIDLEKSYLNY
                     DLVNDSPIDYNQKIEEKIEQNYNGKRKIRKDAVKHIDGLITSGNEFFKNQTLEETKQFF
                     EHAKTFLEQEYGKDNLLYATVHMDEKTPHMHYGVVPITEDGRLSAKEVLGNKKALTEFQ
                     DRFNEHINSCGYDLSRGITRGVTPRRHEQISRYKNLTDYHKEEYEHESRKLDRIKQESE
                     EVMEQYQNALDVLKKPINVPYELETEKVGGLFNKETQETGNVVIDKNEFDLLQEQVKAS
                     QLITDDYEYIKSGKALKDFEEKNKRLEDRLLDEQIKNGKVIDEYNDLADSYNNLLEQNQ
                     EKEKELNRSYKLFNNVFKLIKGVMKEETYHSLINHIDNHLESSKMRETMIVDDNDEQFF
                     KKKYQRHEPEIIFEDERDDGYTL"
                     /name="plasmid recombination protein"
     gene            12666..13283
                     /locus_tag="HJI04_12075"
     CDS             12666..13283
                     /locus_tag="HJI04_12075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017465246.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CadD family cadmium resistance transporter"
                     /protein_id="QRJ17125.1"
                     /translation="MIQTIVTAAILYIATAVDLLVILLIFFARAKTKKEYRDIYIGQYV
                     GSVALIVVSLFFAFVLNYVPEKWILGLLGLIPIYLGIKVAIYDDCEGEKRAKKELNEKG
                     LSKLVGTVAIVTIASCGADNIGLFVPYFVTLSVTNLLITLFVFLILIFFLVFTAQKLSN
                     IPGVGEIVEKFSRWIMAVIYIALGLFIIIENDTIQTILGFIF"
                     /name="CadD family cadmium resistance transporter"
     gene            13302..13649
                     /locus_tag="HJI04_12080"
     CDS             13302..13649
                     /locus_tag="HJI04_12080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="QRJ17126.1"
                     /translation="MSYENACDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKISVASTSHHLRLLYKNDVLDFYKKGKMAYYFIKDDEI
                     KEFFSKNQEGF"
                     /name="helix-turn-helix transcriptional regulator"
     gene            13818..13919
                     /locus_tag="HJI04_12085"
     CDS             13818..13919
                     /locus_tag="HJI04_12085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000228874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="QRJ17127.1"
                     /translation="MVEALVHITTTVISGCIVALFTHWLRTRNNKKK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            14301..14508
                     /locus_tag="HJI04_12090"
                     /pseudo=""
     CDS             14301..14508
                     /locus_tag="HJI04_12090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003691021.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            complement(14594..14743)
                     /locus_tag="HJI04_12095"
     CDS             complement(14594..14743)
                     /locus_tag="HJI04_12095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019469204.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin"
                     /protein_id="QRJ17128.1"
                     /translation="MKTLNEKQLKDINGGKGIVGEVTGEVTSIGNAISNGWHDLKQSVA
                     DTTK"
                     /name="bacteriocin"
     gene            complement(14764..14907)
                     /locus_tag="HJI04_12100"
     CDS             complement(14764..14907)
                     /locus_tag="HJI04_12100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019469205.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-type signal sequence"
                     /protein_id="QRJ17129.1"
                     /translation="METLNEKQLKDINGGRETGCSGDFVEDGIMCNIGQGIGKAINKVR
                     GK"
                     /name="bacteriocin-type signal sequence"
     gene            complement(15064..17220)
                     /locus_tag="HJI04_12105"
     CDS             complement(15064..17220)
                     /locus_tag="HJI04_12105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002440725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="QRJ17130.1"
                     /translation="MAIKFIRQYDEKDCGPTCLAMISQFYGKRVSIPRLREYAKTDKLG
                     TNLYGLVQAGKKIGIELTGVKADSFDDLKQAQLPVMVHIINQQGYDHYIIIEKIKNNTL
                     YIVDPAKGKYKLSSTEFGKYWTNIAVLIDKTDDFTTDNESPSYLNIFIDIFKNNYGKLL
                     FIAFISLFINIVGIVGALYFKLLTDHIIPSNVLKNLHIISFGILLLYIINALINYLRFQ
                     LILHLSLKIDVNLMKDYFYHVLHLPMNFFDTRKSGEILQRFMDTSKIREALSSSTVTLL
                     VDTFMIIIGAILLYMQSPLLLLITIIFIPCFIICSYTLRKPFEKYNQKVAEKDAELSSY
                     LIESFDGSNTIKSYQSEDDRFYIGTTKFNGIIENLLKLGRFSNIQLTVNNFLKLTISLV
                     ILWLGSYLVMTDSMTLGSLLAFNALTIYYLDPIERLINIQPTLQSSFVAARRIAEITDL
                     ETETELYTSKQPYTFKNNIRIENVNFQYGFRSVVLKDINLNIKKGQKVAIVGESGSGKS
                     TIGKLLNRYYTASEGNIMIDNYIIDDIDLSDLRKNIGYVSQNTFLFADTIKNNLLHGSN
                     KYKSDEDIVKACQLAESLDFIQKFPDQFNTMLEKEGANLSGGQGQRLSLARTFLKDPDI
                     YIFDEATSALDSLTENKIMEHIDLLTQHGKTVIIISHKLSTIKNADNIYVLNEGQIAEN
                     GTHDELIHLNGIYKNLWQLQMKID"
                     /name="peptidase domain-containing ABC transporter"
     gene            17448..18065
                     /locus_tag="HJI04_12110"
     CDS             17448..18065
                     /locus_tag="HJI04_12110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000583530.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="QRJ17131.1"
                     /translation="MIIGYARVSSIDQNLERQLDNLKTFGVEKIFTEKQSGKSVENRPV
                     FQEALNFVRMGDRFVVESIDRLGRNYDEIIETVNYLKEKNVQLMITSLPMMNEVIGNPL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRV
                     IYHRVVEMLEEGQAISKIAKEVNITRQTVYRIKHDKGIILIN"
                     /name="recombinase family protein"
     gene            complement(18341..19663)
                     /locus_tag="HJI04_12115"
     CDS             complement(18341..19663)
                     /locus_tag="HJI04_12115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002498867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Nramp family divalent metal transporter"
                     /protein_id="QRJ17132.1"
                     /translation="MKKSLEEINGKVSFDSEANGIKKLIMYLGPGLLVAVGYMDPGNWI
                     TSMAGGAQFGYTLLFIILLSSLSAMLLQSMCARLGIASGMDLAQVTKHISNKPLSIAAW
                     IVTELAIMATDIAEVIGSAIALNLLFDIPLVVGVTITVLDVLLLLLIIKFGFRKIEAIV
                     GVLIFTVLFIFVFEVYFASPEWSAVLGGFIPSTEIATNKGVLYMALGIIGATIMPHNLY
                     LHSSIVQSRNYIRESKAKKKEAIKYAIIDSHIQLSIAFIINCLILILGAALFFGNGEDL
                     GRFYDLYNALQESEFAGAIGGAVMSTLFAIALLASGQNSTITGTLSGQIVMEGFLNIKI
                     PQWARRLVTRLIAVIPVFICLWLYGSSTSKIEDLLIFTQVFLSLALPFSIIPLTLATNN
                     PKIMGKEFTNKTWINIIAWVLTIILSILNIYLIIETFNEFL"
                     /name="Nramp family divalent metal transporter"
     gene            complement(19884..20171)
                     /locus_tag="HJI04_12120"
     CDS             complement(19884..20171)
                     /locus_tag="HJI04_12120"
                     /inference="COORDINATES: protein motif:HMM:NF019500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two pore domain potassium channel family protein"
                     /protein_id="QRJ17135.1"
                     /translation="MYFKFETLKTLLLKGSVFSCISILFSAIPLTYFEPSVRSYNDGVS
                     LAIVTVTTVGYGDISPETLIGRITSVYLMFFWYRFSWNDNRFNSNLFSEK"
                     /name="two pore domain potassium channel family protein"
     gene            complement(20203..20890)
                     /locus_tag="HJI04_12125"
                     /pseudo=""
     CDS             complement(20203..20890)
                     /locus_tag="HJI04_12125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002498866.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            complement(21116..21883)
                     /locus_tag="HJI04_12130"
     CDS             complement(21116..21883)
                     /locus_tag="HJI04_12130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002489261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="QRJ17133.1"
                     /translation="MRTIKMVADELGVTKQTIVNNAKSLNITFEKENGINYIDDNDYLK
                     IIEKITKKESTIQNKESVKKELFGENTAKSEKNIYNNSNSSETLKTKVNELEKQIEIFE
                     TRAKNDEKYIENLTKQLDQQNSNVNTLNKLLENQQILALESNKKIQKLESQLEEERQLN
                     YSFDTATNNRQNINPQEATFTEESQNINQQQTKRQPTEVNYKDIAEEKKNDSTDEGELT
                     KEDKFVEETKSDPDDNREVEPSKKGFWSRFFGN"
                     /name="DUF536 domain-containing protein"
     ARG             complement(7083..7852)
                     /name="ANT(4')-Ia"
                     /gene="ANT(4')-Ia"
                     /gene_name="ANT(4')"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="99.21"
                     /coverage="101.19"
     BGC             10064..22223
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          2..936
                     /name="rep_cluster_1215"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.145"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(3521..4468)
                     /name="rep_cluster_1018"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.895"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(4696..5954)
                     /name="MOBV"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="96.19"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          11108..12429
                     /name="MOBV"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="99.093"
                     /coverage="99.0"
                     /evalue="0.0"
ORIGIN
        1 atgcccaatt ttgaaaaata caatttatca caagtaaaaa ctgaaaggtt ttatcaacta
       61 cctaaatatt tattcgaaga tgcatatttt aaaaaaatgt cggcggaagc caaaattatg
      121 tatgcgttat taaaagatcg ctttgaatta tccatccaaa atgaatgggt agataaaaat
      181 aataacattt actttatttt cagtaataaa catttgtgcg aatacttagg ttatgcagaa
      241 caaaaaatta taaaattaaa aaaagagtta ataagtttta atttattaac tcaagaacgt
      301 gttggcctta ataaaccaaa tagattatat ttattaaaac ctaattatga cattaaagcc
      361 agtcatagca aggaacttcc aaattcacag ttccagaaca atgaatttgg aagttctaga
      421 actgtgaatt taagtggtca agaacttcca aattcacagt ctaatgatac tgagaataat
      481 gatactgatt atattaaaac tgagagtaat gatacgaatg atttgaatga taataagcta
      541 acttttccta gtaatcatac aaatcattca aatcacaaca attcaaactt taataatgaa
      601 gctttaaaat tccaattact cgaagaacta cctcaaagta ttcaaaggta tttaagtaac
      661 ttttctgtaa atgaaattaa aatcatcaaa cctgtattat taaaagccaa gacgtccttt
      721 aataattcta ttgatacata ttacttatta gaagatatgg aaatagaaat acttcatgtt
      781 cttaaacgtt tcaaagctat gcttattcaa aaaaatgaaa ccgttgaagc catgcaaggg
      841 tacttaatga aatcccttaa gtctgaattc gctgaaatgc atacgcttaa taaacgacgt
      901 gatcatttac caatcacttc tttatttaat caataatgat tcaattagag agcatcttta
      961 aatagatgtt ctcttttttt atttacaagt ggttgctaag gcaaccacct agatcaaacg
     1021 aaaggtaagg gaggggataa caaaataaga tcaacacaat atcacaatat agcatgctgc
     1081 tattaaagaa aggaggaaga cttatgagta ctaagaaaaa gattaaagtt actttggcaa
     1141 tgattaatgt tcttttaact gcagtcgaac tttatcttca atggcaattg agtaaatctg
     1201 aaaatgaact gtagttaaac aagtaggtag gactaaaacg tttctgtttt agtcctattt
     1261 tttctataaa tggttattat tcatttgaaa atggctcaaa catgtcgcat aagatgaaaa
     1321 ataaaatgat catttaacgt tgttttaact ttaaaaatta taaaaatact aaccgttttt
     1381 atattcttta gcaatctttc ttagttataa aagtaactta ataaaatcgt ttttgtcatt
     1441 tactttgtta atgatcggaa agaaaagatt gattttatca ttccaaaaaa tcaaaattca
     1501 gattcaattg atatacatca taaacaaaaa gtaagtcgtt aatgttcaag acataagtcg
     1561 aatgtaattt taaatttgat tttttctatc ccaaactgag taaagatatt tacttagttt
     1621 tctttttttt ttatctccaa ttattttact aacaatgctt attttgaaaa taaaaataag
     1681 cacttaaagt aaaaagtgaa caagagaata gccacttttg tcttaaagca cgttttgttt
     1741 ttggaaatat tacaaatata ataggatttt caaatagtat ttgacatgag cataaggaaa
     1801 tccagtacca cctttggtgg tattcagcat agctgaagga ttgtcttacc gttcgctttg
     1861 cttacttgct ctttgaaatt cactacaagt gttgatataa caacatttat agttaatatt
     1921 aaataaaaat taatcgacat tataaacctt aatattgcat actatttaca attgttacaa
     1981 gaccacttta aattgtctga atactattgt ttttattgat ttcataggct tcagtcgtcg
     2041 tcaatcctat aaataggatt gattttttta tccaaatcct attaatccta ttacttttag
     2101 tattaatatc aaaaataaaa tcactcaaaa gtaatctaag taattcattc atttgtttta
     2161 ctttttgaaa ttgactaaat actttttgct caatatcgta ttcaataatg atcttattat
     2221 ttatttttaa gttcaaaaaa gaagggaaag aataaaacaa tttctatact tttctatgct
     2281 cgattttatt aaaaagtgac ccgaaataaa gatcacttta tctttttatt aaatagaaaa
     2341 ttaaaaaaac ggaaaaatat ataataagat tcatcgaatg attactcaaa tttttgtttg
     2401 tgaaatacat ttatatttat ttgattctca tttgcgtttt aagagctaac ttaaaatttc
     2461 agtagctctt actcactttt tggatgataa aagtgaaaat aataccaaaa aatcaagaaa
     2521 agatatttta attataacgt agcatttatg acgaaaaaat ttattgttcg ttgagaagaa
     2581 ctcttaacta aacttataga cgaatgtcgg tatagcgtga gctattaagc cgaccattcg
     2641 acaattttag ggagcaattg tgataaagta ttaatgtttt aaacctgtta catcattgat
     2701 ttcgttggga tgtaacaggt ttgtttcttt taatttggat ttgttgtgag attataaatt
     2761 tataaaaaac aaggagaagc ttatgatatc gaataaatta aaatctgcga gattagcaaa
     2821 ggaattaacg caatctgagg tagctaaaaa attatacgtt actagacaaa ctgtttctcg
     2881 atgggagcaa ggtaaaacgt tgcctaatat ttatgtaatt caagaattaa gcgatcttta
     2941 tgatatttct ttagatgaat tagtagtaaa tacagcatta gaaaataagg aggctaaaag
     3001 tatgaaaaat gtaaatcctt ttgctttatt tggagcgata ttatttaatg tgtttttatt
     3061 ttctttaata gttatatttt ttggtggctt tttgttatta tctttattca tttctttagc
     3121 tatgttattt agtcctttga ttttagcaat ctttgtttta acgggtgtac aagagtttaa
     3181 tgtaattcaa ctagttatga ctgttatttt cgttgttatt ggtttgttat caattccttt
     3241 attgaaaaaa gtcagtgtat ttttatttaa atttttcaaa cgatatttga aatttaatca
     3301 taaagcaatt ttttattgaa tttagaaacg agtttcttta taaaagtaag caaagatata
     3361 atataaaatg aggttctgtt gcaaagttaa attaatatac aaagttatgc aaaagcagta
     3421 aattatatac tattatatca acagattatt cggttggatt ttattatttt tcatttcttt
     3481 gtatctatat tatatgattt tcaagtttgc aacagaacca tccatcttca tcggcttttt
     3541 cgtcatcatc tgtatgaatc aaatcgcctt cttctgtgtc atcaaggttt aattttttat
     3601 gtatttcttt taacaaacca ccataggaga ttaacctttt acggtgtaaa ccttcctcca
     3661 aatcagacaa acgtttcaaa ttcttttctt catcatcggt cataaaatcc gtatccttta
     3721 cagggtattt tgcagtttcg tcaattgccg attgtatatc cgatttatat ttatttttcg
     3781 gtcgaatcat ttgaactttt acatttggat catagtctaa tttcattgcc tttttccaaa
     3841 attgaatcca ttgtttttga ttcacgtagt tttctgtatt cttaaaataa gttggttcca
     3901 cacataccaa tacatgcatg tgctgattat aagaattatc tttattattt attgtcactt
     3961 ccgttgcacg cataaaacca acaagatttt tattaatttt tttatattgc atcattcggc
     4021 gaaatccttg agccatatct gacaaactct tatttaattc ttcgccatca taaacatttt
     4081 taactgttaa tgtgagaaac aaccaacgaa ctgttggctt ttgtttaata acttcagcaa
     4141 caaccttttg tgactgaatg ccatgtttca ttgctctcct ccagttgcac attggacaaa
     4201 gcctggattt acaaaaccac actcgataca actttctttc gcctgtttca cgattttgtt
     4261 tatactctaa tatttcagca caatctttta ctctttcagc ctttttaaat tcaagaatat
     4321 gcagaagttc aaagtaatca acattagcga ttttcttttc tctccatggt ctcacttttc
     4381 cactttttgt cttgtccact aaaacccttg atttttcatc tgaataaatg ctactattag
     4441 gacacataat attaaaagaa acccccatct atttagttat ttgtttagtc acttataact
     4501 ttaacagatg gggtttttct gtgcaaccaa ttttaagggt tttcaatact ttaaaacaca
     4561 tacataccaa cacttcaacg cacctttcag caactaaaat aaaaatgacg ttatttctat
     4621 atgtatcaag ataagaaaga acaagttcaa aaccatcaaa aaaagacacc ttttcaggtg
     4681 ctttttttat tttataaact cattccctga tctcgacttc gttctttttt tacctctcgg
     4741 ttatgagtta gttcaaattc gttcttttta ggttctaaat cgtgtttttc ttggaattgt
     4801 gctgttttat cctttacctt gtctacaaac cccttaaaaa cgtttttaaa ggcttttaag
     4861 ccgtctgtac gttccttaag gaattcctta gtgctttcat agattaaact cacatcacgc
     4921 tttaaatcgc ttattttaga ctttaaagac ttgttttctt caagcaactc attataatca
     4981 tttacatttt cattaaatcg ctctacaaga ccactatatt tttctttaac ttgcccatgt
     5041 tctttactta attttttata ttctctcgcc atatcagtac tcatgagatt tctaacatgc
     5101 tgttttaacc tatcgttatc tctcgcagca gtcactaagt ttttataatc acgctccgat
     5161 ataacaacat ttttggttgg tttcttttct gttttcatta tttcttttcc caaaccaaac
     5221 atggactttt cacccgttgg cacttcaaca cttttcatgt gtcgtttcgc tggtacttct
     5281 aaatctgatt taactttatc gctataagca gtccattcat cttttttaac tgctaaattt
     5341 ttttctagaa aatcaatctc tttttccaaa gtttgttttt taaatttagc tgtctcaata
     5401 tgtttacggt cagagccacg ttcaccacgc ttcaactcaa aaccctgttt tttcatatgc
     5461 tcggggaatt tatcttgtag ccataacagt tcttgacgat taaacacatt ttttccttgc
     5521 agttttccat cacgcatagg cacaacacct aaatgcatgt gaggggtttg ctcatcatta
     5581 tgaactgttg cataagcaat attttgcttg ccatatcgtt cggaaaataa tttataactt
     5641 tcctcaaaaa atcgtttttg ttctcctgga tccagttgct caaaaaaatc tcggtcagat
     5701 gttactagca actcatttac aagaacagca tctttcctcg tttttcttgt acctgttttt
     5761 tgtgattcaa taatttcttt gacacgttcg ttgtaatcaa tatttttatc atttttcaaa
     5821 tcataatttt cacgtgttcg ctcatggtca atatcatcat tcgttctact ttttcgctct
     5881 ctttgattat gaaattgcat gccttttagt ccagctgatt tcactttttg cattctacaa
     5941 actgcataac tcatatgtaa atcgctcctt tttaggtggc acaaatgtga ggcattttcg
     6001 ctctttccgg caaccacttc caagtaaagt ataacacact atactttata ttcataaagt
     6061 gtgtgctctg cgaggctgtc ggcagtgccg accaaaacca taaaaccttt aagacctttc
     6121 ttttttttac gagaaaaaag aaacaaaaaa acctgccctc tgccacctca gcaaaggggg
     6181 gttttgctct cgtgctcgtt taaaaatcag caagggacag gtagtatttt ttgagaagat
     6241 cactcaaaaa atctccacct ttaaaccctt gccaattttt attttgtccg ttttgtctag
     6301 cttaccgaaa gccagactca gcaagaataa aatttttatt gtctttcggt tttctagtgt
     6361 aacggacaaa accactcaaa ataaaaaaga tacaagagag gtctctcgta tcttttattc
     6421 agcaatcgcg cccgattgct gaacagatta ataatagatt ttagcttttt atttgttgaa
     6481 aaaagctaat caaattgttg tcgggatcaa ttactgcaaa gtctcgttca tcccaccact
     6541 gatcttttaa tgatgtattg gggtgcaaaa tgcccaaagg cttaatatgt tgatataatt
     6601 catcaattcc ctctacttca atgcggcaac tagcagtacc agcaataaac gactccgcac
     6661 ctgtacaaac cggtgaatca ttactacgag agcgccagcc ttcatcactt gcctcccata
     6721 gatgaatccg aacctcatta cacattagaa ctgcgaatcc atcttcatgg tgaaccaaag
     6781 tgaaacctag tttatcgcaa taaaaaccta tactcttttt aatatccccg actggcaatg
     6841 ccgggataga ctgtaacatt ctcacgcata aaatcccctt tcattttcta atgtaaatct
     6901 attaccttat tattaattca attcgctcat aattaatcct ttttcttatt acgcaaaatg
     6961 gcccgattta agcacaccct ttattccgtt aatgcgccat gacagccatg ataattacta
     7021 atactaggag aagttaataa atacgtaacc aacatgatta acaattatta gaggtcatcg
     7081 ttcaaaatgg tatgcgtttt gacacatcca ctatatatcc gtgtcgttct gtccactcct
     7141 gaatcccatt ccagaaattc tctagcgatt ccagaagttt ctcagagtcg gaaagttgac
     7201 cagacattac gaactggcac agatggtcat aacctgaagg aagatctgat tgcttaactg
     7261 cttcagttaa gaccgaagcg ctcgtcgtat aacagatgcg atgatgcaga ccaatcaaca
     7321 tggcacctgc cattgctacc tgtacagtca aggatggtag aaatgttgtc ggtccttgca
     7381 cacgaatatt acgccatttg cctgcatatt caaacagctc ttctacgata agggcacaaa
     7441 tcgcatcgtg gaacgtttgg gcttctaccg atttagcagt ttgatacact ttctctaagt
     7501 atccacctga atcataaatc ggcaaaatag agaaaaattg accatgtgta agcggccaat
     7561 ctgattccac ctgagatgca taatctagta gaatctcttc gctatcaaaa ttcacttcca
     7621 ccttccactc accggttgtc cattcatggc tgaactctgc ttcctctgtt gacatgacac
     7681 acatcatctc aatatccgaa tagggcccat cagtctgacg accaagagag ccataaacac
     7741 caatagcctt aacatcatcc ccatatttat ccaatattcg ttccttaatt tcatgaacaa
     7801 tcttcattct ttcttctcta gtcattatta ttggtccatt cactattctc attccctttt
     7861 cagataattt tagatttgct tttctaaata agaatatttg gagagcaccg ttcttattca
     7921 gctattaata actcgtcttc ctaagcatcc ttcaatcctt ttaataacaa ttatagcatc
     7981 taatcttcaa caaactggcc cgtttgttga actactcttt aataaaataa tttttccgtt
     8041 cccaattcca cattgcaata atagaaaatc catctggttc tgttgcaaag ttaaattaat
     8101 atacaaagtt atgcaaaagc agtaaattat atactattat atcaacagat tattcggttg
     8161 gattttatta tttttcattt ctttgtatct atattatatg attttcaagt ttgcaacaga
     8221 acccatcatt ttcccttgat gtattttcat aaatatcaaa taaaaataga gctgaatcac
     8281 ttgcagtatg taaattgact atattaactt catccatttt agcaagttca gtacttttgc
     8341 tacttctcac ttgtgatgta agtttttcta tttcctctaa attacttttt atagaaagtt
     8401 cttttgcaag ttcagagaat tcaacatctg aattcgtata tcctaatcta aaaacattta
     8461 ttttcctagt atattttgct aaatcagatt tcaaactatt aataatccta tcgctatttt
     8521 cttcgaactg tttgtttttt tcttctttat ctttttcttg ttgcttaacg ctattatcat
     8581 atgatttata tgcgataaca agactgataa cagttgtaag gagagtgaat aatgctacaa
     8641 atgcttttaa aatatttgga tattcttcta gaattccctc aatttgataa gagtatttaa
     8701 aaacaataaa tatggagacc actattatga aaatcgatat acgtaacatc ttcttcattc
     8761 taaaacttcc tctctaagcc atataaaaat gttactgact cacattatta tcaaatgatt
     8821 cttataatat ataacatata tcagtatagt tattaaaaca tcaattaaaa atgcatgttt
     8881 tataaatatc attaacccta ttcctattta tatatactac agatataaat aaaataactc
     8941 cgtaattata atatttacgc tcaaacttta tgaactttgc attcctacca attatagtgt
     9001 tacaatgtaa ttaacaaaga ttatcaggca tgtatgcacc aaatcccctt actatggccg
     9061 tagtaagggg attttttggt gtgactagtc gcctattcgt cattacgctt gcgtagccaa
     9121 tgcgcaaata gcgcaacgag acaaccactt gctgctgtgg tcatgatgtt cacaaagatt
     9181 tcagacatcg cgtatgcacc tcctctctac gtcaaattga cgcctgagag ataggcgact
     9241 ctattattat atcatttgta aatacataag catattcact tccgataagt cattttaggt
     9301 tctgttgcaa acttgaaaat catataatat agatacaaag aaatgaaaaa taataaaatc
     9361 caaccgaata atctgttgat ataatagtat ataatttact gcttttgcat aactttgtat
     9421 attaatttaa ctttgcaaca gaaccttaat attactgaac aaaaatgata tatttaaact
     9481 attctaattt aggaggattt ttttatgaag tgtctattta aaaatttggg gaatttatat
     9541 gaggtgaaag aataatttac ccctataaac tttagtcacc tcaagtaaag aggtaaaatt
     9601 gtttagttta tataaaaaat ttaaaggttt gttttatagc gttttatttt ggctttgtat
     9661 tctttcattt tttagtgtat taaatgaaat ggttttaaat gtttctttac ctgatattgc
     9721 aaatcatttt aatactactc ctggaattac aaactgggta aacactgcat atatgttaac
     9781 tttttcgata ggaacagcag tatatggaaa attatctgat tatataaata taaaaaaatt
     9841 gttaattatt ggtattagtt tgagctgtct tggttcattg attgctttta ttggtcacaa
     9901 tcactttttt attttgattt ttggtaggtt agtacaagga gtaggatctg ctgcattccc
     9961 ttcactgatt atggtggttg tagctagaaa tattacaaga aaaaaacaag gcaaagcctt
    10021 tggttttata ggatcaattg tagctttagg tgaagggtta ggtccttcaa tagggggaat
    10081 aatagcacat tatattcatt ggtcttacct acttatactt cctatgatta caatagtaac
    10141 tatacctttt cttattaaag taatggtacc tggtaaatca acaaaaaata cattagatat
    10201 cgtaggtatt gttttaatgt ctataagtat tatatgtttt atgttattta cgacaaatta
    10261 taattggact tttttaatac tcttcacaat cttttttgtg atttttatta aacatatttc
    10321 aagagtttct aaccctttta ttaatcctaa actagggaaa aacattccgt ttatgcttgg
    10381 tttgttttct ggtgggctaa tattttctat agtagctggt tttatatcaa tggtgcctta
    10441 tatgatgaaa actatttatc atgtaaatgt agcgacaata ggtaatagtg ttatttttcc
    10501 tggaaccatg agtgttattg tttttggtta ttttggtggt tttttagtgg atagaaaagg
    10561 atcattattt gtttttattt taggatcatt gtctatctct ataagttttt taactattgc
    10621 attttttgtt gagtttagta tgtggttgac tacttttatg tttatatttg ttatgggcgg
    10681 attatctttt actaaaacag ttatatcaaa aatagtatca agtagtcttt ctgaagaaga
    10741 agttgcttct ggaatgagtt tgctaaattt cacaagtttt ttatcagagg gaacaggtat
    10801 agcaattgta ggaggtttat tgtcactaca attgattaat cgtaaactag ttctggaatt
    10861 tataaattat tcttctggag tgtatagtaa tattcttgta gccatggcta tccttattat
    10921 tttatgttgt cttttgacga ttattgtatt taaacgttct gaaaagcagt ttgaatagtt
    10981 atattatatt ttggtttaga actatgagtg gctagcattt tgccactcat tttttgcgtt
    11041 agcaaaaaca ggtttaagcc tcgcagagca cacgtattaa cgacttatta aaaataagtc
    11101 tagtgtgttt atactttaat aaataaagct acgcaaaaac atgtgcagtg gaggaatttt
    11161 aatatggcgt attctattat cagagttgct aaagtgaaat caaaaacgaa tacaaaaggc
    11221 attcaaaaac atgtacaaag acaaaataaa aattatgaaa atatggatat tgatttagaa
    11281 aaatcatact taaattacga tttagtcaat gatagtccga ttgattataa tcaaaaaatc
    11341 gaagagaaaa ttgaacaaaa ttataatggg aaacgcaaaa ttagaaaaga cgcagtaaaa
    11401 catattgatg gtttaattac atctggtaat gaatttttta aaaatcaaac acttgaagaa
    11461 acaaagcagt tttttgaaca tgctaaaacg tttttagaac aagagtatgg aaaagataat
    11521 ttattatatg caacagtgca tatggacgaa aaaacacctc atatgcatta tggggtagtt
    11581 ccgattacag aagatggtcg attgagtgcg aaagaggttt taggtaataa aaaggcacta
    11641 actgaatttc aagatagatt taacgaacat atcaatagtt gtggttatga cttgagtaga
    11701 ggtataacaa ggggcgttac accgagacga catgagcaga taagtcgtta taaaaattta
    11761 acagattatc acaaagaaga atatgagcat gagagccgaa aattagaccg tataaagcaa
    11821 gaaagcgaag aagtaatgga acagtatcaa aatgctttag atgttctaaa aaagcctata
    11881 aatgtcccat atgagcttga aactgaaaaa gttggtggac tgttcaacaa agaaacacag
    11941 gaaacaggta acgtcgttat tgataaaaat gaatttgatt tattgcagga acaagtaaaa
    12001 gcttctcaac tcattactga tgattatgaa tatattaaaa gcggaaaagc tttaaaagat
    12061 tttgaggaaa aaaacaaaag attagaagat agattattag acgaacagat taaaaatgga
    12121 aaagtaatag atgaatacaa tgatttagcg gatagttata ataatttatt ggaacaaaat
    12181 caagaaaaag aaaaagagtt aaaccgttcg tataaactat ttaacaatgt gtttaagttg
    12241 attaaaggtg tgatgaaaga agaaacatat cattcgttga ttaaccatat tgataatcac
    12301 ttagaaagct caaaaatgcg agaaacaatg attgtagatg ataacgatga acaattcttt
    12361 aagaaaaaat atcaaaggca tgaaccagaa attatttttg aagatgaacg agatgatggc
    12421 tacactttat aaagacgacg catttatgcc gagaaaattt attgtgcgtt gagaagaacc
    12481 cttaactaaa cttgcagacg aatgtcggca tagcgtgagc tattaagccg accattcgac
    12541 aagttttggg attgttaagg gttccgaggc tcaacgtcaa taaagcaatt ggaataaagc
    12601 atctatgatt atttgaaaac ataagttata atacattcaa aaatattttt gaatgaggtg
    12661 taattatgat tcagactatt gtaactgctg ctattcttta tattgcgaca gcagtagatt
    12721 tattagtgat tttattaata ttttttgcta gagcaaagac taagaaagaa tatcgagata
    12781 tttatattgg tcaatatgta ggatctgtgg cattgattgt cgtaagttta ttctttgcct
    12841 ttgtcttaaa ttatgttcct gaaaaatgga tattaggatt attagggtta ataccgattt
    12901 atttaggaat taaagtagct atttatgatg attgtgaagg agaaaagaga gctaaaaaag
    12961 aattgaatga aaaaggattg tctaaattag ttggtacggt tgcaattgtt acgatagcaa
    13021 gttgtggtgc tgataatatt ggtttatttg ttccgtattt tgtgacatta agtgttacta
    13081 atttattaat tactctgttt gtctttttaa ttttaatttt cttcttggta tttactgcac
    13141 aaaaattatc taatattcca ggagttggag aaattgttga gaaatttagt cgttggatta
    13201 tggctgttat ttatatagct ttaggtttat ttattattat tgaaaatgat actattcaaa
    13261 caattttagg atttatattt taatttaggg tgcgatttta tatgagttat gaaaatgctt
    13321 gtgatgtgat ctgtgtacat gaggataaag ttaacaatgc tttaagtttt ttagaagatg
    13381 ataaatctaa gaaattactt aacattttag aaaaaatttg tgatgagaag aaattgaaaa
    13441 tcatattatc tttgattaaa gaagatgagt tgtgtgtttg tgatatttct ttgatattga
    13501 aaataagtgt tgcttcaact tcacatcatt taagactttt atataaaaat gatgtacttg
    13561 atttttataa aaagggaaag atggcatatt attttattaa agacgatgaa ataaaagaat
    13621 ttttctctaa aaatcaggag ggtttttgaa acgagtgaaa cgagtttctt cttgtcttga
    13681 tactataaaa aagcaaagat ataacataaa atgacttatc ggaagttatc tattatccct
    13741 tattcagaga tgatataata tacaggtcgc ctatctctca ggcgtcaatt tagacgcaga
    13801 gaggaggtgc atatcagatg gtcgaagctc ttgttcacat cacgaccaca gtcatcagtg
    13861 gttgtattgt tgcgttattt acgcattggc tacgtacacg taacaataag aaaaaatagg
    13921 cgatattagc caacacctaa aaatcccctc actattgcga gtagtgaggg gattggtgca
    13981 tataatgtac gaagctcttg ttgtctaaat tataacactg gttagtagaa gaatgcaaaa
    14041 cacttatatt aaaaaatggg tatctttgag tagtatcata agttatagta tagaaatatt
    14101 taagtgtttg tattcagaat ttagttttcc gttaaatgat gtattgctag aaggtactga
    14161 taaaaaagcg agtaaagaat atataaacaa gaatcaaaaa actttttatt gtctataatc
    14221 atctattact ttctttttac tagtaacttc gataattgca aacagtatca ttggttatta
    14281 aaaaaataaa agatgcaaaa atggctaaat attggaaaga aaatcaagag ggattattaa
    14341 atgatgggga agcattaact atattaatga tgttatataa tgagcatcca tatgtagtac
    14401 aattaccgtg tttaaataag caactacaag atgacaacag atacgctcaa cccacgtata
    14461 ctatatattc tacaaccaaa aacagaaaag agaataaaag aagaataaaa aatagcatat
    14521 aaccttaata agataattaa ttttgttata ttaaaataat atatagataa tttaattatt
    14581 taaataatga gtcctatttt gtagtatcag cgacagactg ttttaaatca tgccaaccat
    14641 ttgaaatggc attaccaata ctagtgactt cgccagtgac ttcaccaaca atccctttac
    14701 caccattgat atcttttaat tgtttttcat ttagtgtttt cattgaaata gtcctccttt
    14761 aaattatttt cctcgtactt tattaattgc tttaccaata ccttgtccga tattgcacat
    14821 tattccatct tctacaaaat caccagaaca accagtttca cgaccaccat tgatatcttt
    14881 taattgtttt tcatttagtg tttccattga aatagtcctc ctttaagtaa tttcatctta
    14941 catcttataa attagcattt gaatataaag agaatgtaaa tagacagtta agtgagcttt
    15001 tttttgagtt tatttttttt attatcgaaa tatatttaat aaatagagta tattaatata
    15061 aaatcagtct attttcattt gaagttgcca taaattttta tatataccgt ttaaatgaat
    15121 caactcatca tgtgtaccat tctcagcaat ttgaccctcg tttaaaacat agatattatc
    15181 agcatttttt atagtactta atttatgtga aataataatt acggttttac catgttgagt
    15241 tagtaagtca atatgctcca taattttgtt ttcagttaaa ctatctaagg cacttgtagc
    15301 ttcatcgaaa atatatatat caggatcttt taaaaatgta cgtgctaaag ataagcgttg
    15361 gccttgtccg cccgatagat tagctccttc tttttctaac atagtgttaa actgatctgg
    15421 gaatttctgt ataaaatcta aggattctgc taattgacaa gctttaacga tatcttcatc
    15481 acttttgtat ttattgctac catgtaaaag attgttttta attgtatcag caaaaaggaa
    15541 tgtgttttgt gaaacatagc ctatattctt acgtaagtca gaaagatcaa tatcatcaat
    15601 aatatagtta tcaatcataa tattaccttc tgaagcagtg taatagcgat tgagtaactt
    15661 acctatagtt gatttaccac taccactttc accaacaata gcaacctttt gccctttttt
    15721 aatatttaaa ttaatatcct tcaataccac acttcgaaag ccatactgaa agtttacatt
    15781 ttcaatgcga atgttgtttt taaaagtata aggttgttta gaagtatata attcagtttc
    15841 ggtctctaaa tcagttattt cagcaatacg acgtgctgca acaaatgaag attgcagtgt
    15901 tggttgaata tttatgagac gttcaatagg atcaaggtaa taaatagtta aggcattaaa
    15961 agctaataaa ctacctaacg tcatactatc cgtcatgact aagtaactac caagccacaa
    16021 tataacaaga ctgatagtta attttaaaaa gttgttaacc gttaattgta tattagaaaa
    16081 tctacccagt tttaataagt tttcaataat accattaaat ttagtagtac caatgtagaa
    16141 acgatcgtct tcagattgat aacttttaat agtattacta ccatcaaagg attctattaa
    16201 atatgaactc aattcagcat ctttttcagc caccttttga ttatattttt caaaaggttt
    16261 acgtaaagtg taactacaaa taataaaaca aggtataaaa ataattgtta tcagtagtaa
    16321 caaaggactt tgcatataaa gtaatatagc accgataata atcatgaaag tatcaactag
    16381 caacgttacc gttgaagatg ataaagcttc acgaatttta gatgtatcca tgaaacgttg
    16441 taggatttcg ccagatttac gtgtatcaaa aaagttcatc ggaagatgta aaacatgata
    16501 aaaataatct ttcattaaat taacatcgat tttcaaactt aaatgtaaga taagttgaaa
    16561 ccttaaataa ttaatgagtg cattgattat gtataaaagt aaaataccga agctaataat
    16621 atgtaaattt ttaagaacat tggatggaat aatatgatcg gttaataatt taaaatatag
    16681 agccccgaca ataccaacaa tattaataaa tagtgagata aaagcaataa ataacaactt
    16741 tccataatta tttttaaata tatcaataaa aatattaaga tacgagggtg attcattgtc
    16801 agtagtaaaa tcatctgttt tatcaattaa tacagcaata ttagtccaat attttccaaa
    16861 ttcagtactt gataacttat atttaccttt agcaggatcg acaatataaa gcgtgttatt
    16921 ttttattttt tcaataatga tatagtgatc ataaccttgt tgattaataa tatgtaccat
    16981 aactggtaat tgtgcttgtt ttaaatcatc aaaggaatca gcttttacgc cagttaactc
    17041 aataccaatc tttttacctg cttgtacgag accatataaa tttgtaccta atttatctgt
    17101 tttagcatat tcgcgcaaac gtgggataga tacacgctta ccataaaact gtgaaatcat
    17161 ggcaaggcaa gtaggaccac aatccttttc atcgtattgt cttataaatt ttatagccat
    17221 cataatgagt cctttcaata aaatttaact ctattttaat aagtataaat agttagtatt
    17281 aaacataagt taaataatcc ttttgataat gttaaaagcg ctaaaaagta aaaatatttg
    17341 tctatatgtc tacttgtggt acaccctaat catacaaaat aagttgttga aattatcgca
    17401 attaaaacgt atgattaggg tgtatattaa tcatggagtg aagatgaatg attataggtt
    17461 atgcgagagt atcatcgata gatcaaaatt tagaaagaca attggataat ttaaagacgt
    17521 ttggtgtgga gaaaatcttt acagagaaac agtcgggaaa gtcagtggaa aatagacctg
    17581 tatttcaaga agcactcaat tttgtcagaa tgggagatcg attcgttgtg gaatctattg
    17641 atcgtttagg acgtaactat gatgaaatta ttgaaactgt gaattattta aaagaaaaaa
    17701 acgttcagtt aatgattacc agcttaccta tgatgaatga agtgattggc aatccattac
    17761 tggataagtt tatgaaagat ttaatcattc aaatattagc aatggtttca gaacaagaga
    17821 gaaatgaaag taaacgtcga caagcgcaag gaattcaagt tgcgaaggaa aaaggcgtat
    17881 ataaagggcg ccccttactt tattcaccaa atgctaaaga cccacagaaa cgtgttattt
    17941 atcatcgcgt ggtggaaatg ttagaagaag ggcaagcaat tagtaaaatt gccaaagaag
    18001 ttaatattac aagacaaaca gtttatagaa ttaaacatga taaggggatt atcttgataa
    18061 attgattgtc aatgcaaatg agcgtttctc acagcgtccc aaaatatatg ttaatcatgt
    18121 attatgagat tttaataata agacaggaaa aagagagagc gtttttgccc tctttttttc
    18181 tatatttttt ctcaataacg aataattttg acaacctaat catacataca gaaatactgt
    18241 tttactagca tcaataatgg ttcaattaag gtaggctcca aatagacaaa aaacacacct
    18301 tcttatttta ctaagaagat gtgtttttaa atcaattaaa ttataaaaac tcattaaatg
    18361 tttctataat tagatatata ttcaatatac ttaatatgat tgttaaaacc caagcaataa
    18421 tattaatcca tgttttattt gtaaattctt ttcccattat cttaggatta ttggttgcta
    18481 acgttaaagg aataatacta aagggtaatg caagacttaa aaatacttgt gtgaagatta
    18541 aaagatcttc aatcttagaa gtacttgaac catataacca taaacatatg aatacaggaa
    18601 tcacagcgat taatctagta actaatcttc ttgcccattg aggtattttt atattcaaaa
    18661 acccttccat gacaatttgt cctgataatg tgccagtaat ggttgaattt tgtcctgaag
    18721 ctaacaaagc tatggcaaat aatgtactca taacagcacc acctatagct cctgcaaact
    18781 cggattcttg taaagcatta tataaatcat aaaatcgtcc taagtcttca ccattaccaa
    18841 agaatagagc ggcacctaat attaaaatca aacaattaat aataaacgca attgaaagtt
    18901 gtatatgtga atcaataata gcgtatttaa tagcctcttt tttcttagct ttactttcac
    18961 gtatatagtt acgtgattga acaattgaag aatgcaaata caaattatga ggcatgattg
    19021 tcgcaccaat gatacctaaa gccatgtata acacaccctt gttagtagct atttctgtac
    19081 ttggaataaa gccacctaaa acagcactcc attctggaga agcaaagtaa acttcaaata
    19141 caaagataaa aagaactgta aaaattaata cacctacgat agcttcaatc tttctaaagc
    19201 caaatttaat aattaatagt aaaagtaaaa catctaatac agtaatagtt actcccacta
    19261 ctaaaggtat atcaaaaagt agatttagtg ctatcgcact accaatgacc tctgcaatat
    19321 ccgtagccat aattgctaat tctgtaacaa tccaggctgc tatcgataac ggcttattac
    19381 ttatgtgttt agttacttga gctaagtcca taccactcgc aatacctaaa cgagcgcaca
    19441 tactttgaag taacatggct gataagctcg ataataatat tataaataat aatgtatatc
    19501 caaattgtgc tcctcctgcc attgaagtaa tccaattacc tggatccata tagcctacag
    19561 caacaagaag tccaggacct agatacatta ttagtttctt gataccattt gcttcgctat
    19621 caaaagaaac ttttccattt atttcttcta aacttttctt cactataaaa atctcctcat
    19681 tgaatattaa atttatcaat gaatattata gtataaatta ggctgaccta aaaattattt
    19741 tgcttcatat atattttttc tcattaaaat tttagtcacg atacgttttg attattttaa
    19801 ttaatctttc tatatcatta tttgagaggt tttctatatt gtctatgtca tgtttaagcg
    19861 actcttttat attagacttc tcattatttt tcagaaaata agttgctatt gaacctgtta
    19921 tcattccaac taaaccgata ccaaaaaaac atcagataaa cacttgttat tctgccaatt
    19981 agtgtctctg gactgatatc accatagcca actgtagtaa ctgtcactat agctaacgaa
    20041 accccatcat tatatgatct tacagatggc tcaaaataag taagtgggat tgcagaaaat
    20101 aatatgctaa tacatgaaaa gacacttcct tttaaaagaa gtgtcttaag cgtttcaaat
    20161 ttaaaatata tctaaataac gaacattttt aatatggagg gattatgttt ttcttgattt
    20221 aactttttcc cattcaattt tcaggtaatt attaataaaa tctttatatt catctatttt
    20281 tgtttcttct aaagtattat taccatcata agattctctg atattttttt ttaattcatt
    20341 taaagaatca tagattttct cattgctaat tgataaatcc cctttataaa aacttgcact
    20401 actttcaact gcaactagta ttttttttat gttcgattcg tactttatga atatcatatt
    20461 tatttatcgg aaataaattt ttcattactt ctatagaagt aaatagatta tacatagcac
    20521 tggttctatc tatttttttg ttatttaaaa ccttcgtttg ttcctttacc ttttcttgta
    20581 tattgtctat ttcttctttg tatttttccg cattattgtc tcttttcctt gattcatatt
    20641 ctaaaccttc taacaaggtg cttctcatat tatctaacat attaatatct ttagtttttt
    20701 cactataaaa attttgatga gtgttgaaat cataaaatgc ttttatcaaa ttagtattta
    20761 cttctcttac tttctgaatc caatttatcc ttgaatcttc aatttcagat tttcttttca
    20821 ttgaattgtc tattttataa cccacccaca ctgacgttaa actaattaat gctacaaaaa
    20881 tggcaaacat atttttcatc atccaatctt tttattcttt cgtctgcttt tagttgcaat
    20941 aacttaactt ttagtttaga taagttattg cattaggctg tgctttacat atatatttaa
    21001 agattgctcc tctttaaata attagttaac ataatcgatg attatcagaa gtttcatcac
    21061 tataaaaggt gtatcaaaga tttatacccc cttgatacac cttttacatt catttttaat
    21121 taccgaagaa tcgactccaa aatccctttt tagatggttc tacctcccta ttatcatcag
    21181 gatcactctt cgtttcttca acgaacttat cctcttttgt taattcacct tcatctgtac
    21241 tgtcattctt tttctcttcg gctatatcct tgtaatttac ttctgttggt tgacgctttg
    21301 tttgttgttg gttgatattt tgcgattctt cagtaaaagt tgcttcttgc ggattaatat
    21361 tttgtctatt attcgtcgct gtatcaaaag aataattaag ctgtctttct tcttctaatt
    21421 gactttctag tttttgaatt tttttattgc tttctaaagc taatatttgt tgattctcca
    21481 acaatttatt taacgtatta acattgctat tttgttgatc taattgctta gttaaattct
    21541 caatatattt ttcatcattt ttagctctag tttcaaagat ttctatttgc ttttctaatt
    21601 cgtttacttt tgtttttaat gtctcagaac tatttgaatt attatatata ttcttttctg
    21661 attttgcagt attttcacca aacaattctt tttttactga ttctttattt tggattgtac
    21721 tctctttctt agtaattttt tctataattt tcaaataatc attatcatca atataattaa
    21781 tcccattttc tttttcaaaa gttatattta aacttttagc attattaaca atagtttgtt
    21841 tagttacacc taattcatca gcaaccattt taatagttct cataacatcc acccttaggt
    21901 acctaattta gtacctaaat tttaccacct aatgaatttt atttcatcaa ttaccactaa
    21961 atttactacc tatttactac atatgcacct aattagctac ctataatatg tttttggagc
    22021 ttaattaggt actaaaacaa tgaactacac attttgccat ggcaatgtgc ttttaactac
    22081 atttaaaact ctttatatac tttcttaaaa gtgttaatat tgctttataa atactaaaag
    22141 agtcaatgct attggcgtag cattgactct cggtaataaa acgattcgca ctcgtttgtt
    22201 tatatatttt ttgatacttg tattatatct atctaatcat ctaagtgcaa gcacaaaaca
    22261 tataacttac gtaaaaattg ttttattacc tcaatcctaa aaatggaaat gaggttttta
    22321 tt
//
