LOCUS       CP052949               30151 bp    DNA     circular BCT 09-FEB-2021
DEFINITION  Staphylococcus epidermidis strain HD69-1 plasmid pHD69-1_1, complete
            sequence.
ACCESSION   CP052949
VERSION     CP052949.1
DBLINK      BioProject: PRJNA546129
            BioSample: SAMN14732906
KEYWORDS    .
SOURCE      Staphylococcus epidermidis
  ORGANISM  Staphylococcus epidermidis
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 30151)
  AUTHORS   Both,A., Huang,J., Qi,M., Lausmann,C., Weisselberg,S., Buttner,H.,
            Lezius,S., Failla,A.V., Christner,M., Stegger,M., Gehrke,T.,
            Baig,S., Citak,M., Alawi,M., Aepfelbacher,M. and Rohde,H.
  TITLE     Distinct clonal lineages and within-host diversification shape
            invasive Staphylococcus epidermidis populations
  JOURNAL   PLoS Pathog 17 (2), e1009304 (2021)
   PUBMED   33544760
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 30151)
  AUTHORS   Both,A., Huang,J., Qi,M., Lausmann,C., Weisselberg,S., Buettner,H.,
            Lezius,S., Failla,A.V., Christner,M., Stegger,M., Gehrke,T.,
            Baig,S., Citak,M., Alawi,M., Aepfelbacher,M. and Rohde,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-APR-2020) Institute of Medical Microbiology, Virology
            and Hygiene, University Medical Center Hamburg-Eppendorf,
            Martinistr. 52, Hamburg, Hamburg 20246, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. v0.4.7
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 67x
            Sequencing Technology             :: Illumina; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/29/2020 13:30:47
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 2,339
            CDSs (total)                      :: 2,255
            Genes (coding)                    :: 2,190
            CDSs (with protein)               :: 2,190
            Genes (RNA)                       :: 84
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 61
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 65
            CDSs (without protein)            :: 65
            Pseudo Genes (ambiguous residues) :: 0 of 65
            Pseudo Genes (frameshifted)       :: 40 of 65
            Pseudo Genes (incomplete)         :: 28 of 65
            Pseudo Genes (internal stop)      :: 20 of 65
            Pseudo Genes (multiple problems)  :: 19 of 65
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..30151
                     /organism="Staphylococcus epidermidis"
                     /mol_type="genomic DNA"
                     /strain="HD69-1"
                     /isolation_source="nose; prosthetic joint infection"
                     /host="Homo sapiens"
                     /db_xref="taxon:1282"
                     /plasmid="pHD69-1_1"
                     /geo_loc_name="Germany: Hamburg"
                     /lat_lon="53.33 N 10.1 E"
                     /collection_date="2018"
                     /collected_by="Institute of Medical Microbiology, Virology
                     and Hygiene, University Medical Center Hamburg-Eppendorf"
     gene            1..936
                     /locus_tag="HJI10_11515"
     CDS             1..936
                     /locus_tag="HJI10_11515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001831383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="QRJ03168.1"
                     /translation="MSKFKKISASEFETSRFYQLPKFLFEDGHFSKMTTDAKVMYALLK
                     DRFELSKINNWIDEENNIYLLYTNKQLCSILQYGEPKIIKLKKELEKFNLIINERQGLN
                     RPNKIYLLEPSYDKELTNRKFQNKQIISSRTNENIVQELTICKSNDTDINDTENKETEN
                     NDTYDMNDSEHIANPNTSHSNHPNHQSNEFDNNALKYHLLQEIPDQLQTYLNNFEVDEI
                     QIIKSVILKAKSSFNNEKNTVYMLEDIEFEMINVLKRFKATLIQKSESVEAMQGYLMRS
                     IKTELEEMHSLNMRRQNAPQNHIFDTSHYL"
                     /name="replication initiator protein A"
     gene            complement(927..1496)
                     /locus_tag="HJI10_11520"
     CDS             complement(927..1496)
                     /locus_tag="HJI10_11520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000159079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Replication protein RepB"
                     /protein_id="QRJ03169.1"
                     /translation="MTKDKRSNKWAFLIYEESTPSNYQDILEQMHIPYILSPWHNQDID
                     QSTGLIKKSHKHGALFFDSLKSYSQVSELLQQHLNTPRHIEIIMSPKGMFDYFIHASNS
                     DKTLYDINDIESGCGFDLNQFLLDQGQSEVFNNIIDMIENHNFIEFQDLVMYARQHHPS
                     YLNLIIQRTYFFAKYLDSRRHTFNHK"
                     /name="Replication protein RepB"
     gene            complement(1620..2222)
                     /locus_tag="HJI10_11525"
     CDS             complement(1620..2222)
                     /locus_tag="HJI10_11525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001233000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QRJ03170.1"
                     /translation="MRKTYFMRVYDIIIYLFLFAILTVMVSKLFVLLNFIVSQIDIIDT
                     RNVTHYITIISNGVYQLTFYLLVLALMLIVIDLMIRLLKDQLTNHIKSVYHTMVLRHYL
                     KQDVDTDTTQDWQNNGKSKTNSVQQYFNKMVGKSLVDVRQNEVRVAIKIPRKQQAHDIL
                     KKIEPQIHEEITHMHPNYYFSKPQRHHRYLWFAGHKR"
                     /name="hypothetical protein"
     gene            complement(2222..3298)
                     /locus_tag="HJI10_11530"
     CDS             complement(2222..3298)
                     /locus_tag="HJI10_11530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002272712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsK"
                     /protein_id="QRJ03171.1"
                     /translation="MTAKELEQYLLQSLNMALGSMMQGETSYTNSFTCKVTEEGFYFLP
                     RLPAGYIVDDDLYQKIFLIASAALYPKFTLLKQNSAYFVPMDTDDIHTQRALFFPWQQG
                     ISERLVISDLDRFTSSLTNQQIPIMKQLTLNYQNITSIAIAGNSGSGKSYMLTYLLSVL
                     KPISELIIVDPKFDTPSRWARIHDITVIHPHQNRSKSDFLSEINENLSHCLQVIQQRQT
                     ILYDDPDYQFDHLTIVIDEVLALAEGVNKTIKDAFFSLLSQIALLGRATKVHLLLVSQR
                     FDHQTIPVSVREQLNVLIQIGNINKKTTQFLFPDLDPEGIVIPIGKGTGLIQVIDSESP
                     YQVLPLLCPTYYTKAGVL"
                     /name="cell division protein FtsK"
     gene            complement(3298..3618)
                     /locus_tag="HJI10_11535"
     CDS             complement(3298..3618)
                     /locus_tag="HJI10_11535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002466864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QRJ03172.1"
                     /translation="MKIQSNFKKGGYSTEIASNYIDNKKPIYSLSTELYPQQRFENNQP
                     TGEIIAYKAWFVQEGLPPFTVKFENEVTLPNYMSVITFDHLEACEVRYDVYFKASDLKE
                     VK"
                     /name="hypothetical protein"
     gene            3767..4966
                     /locus_tag="HJI10_11540"
     CDS             3767..4966
                     /locus_tag="HJI10_11540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002488420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QRJ03173.1"
                     /translation="MIIINNKGINDLDFNYWMNNQLTDDNIEEILEGSDLSMEQEIFKS
                     NYKKFLEIDGKKERWYSLEEAAYIINGNYFSIYEEDSKKRSVTTDYVKNKSNDILNNIE
                     NGTNQNWNKYHYPQKRKFAFKKVKYVNEDMIDEILRDDVTKPEKIKRGNISIEELLPNQ
                     NRIAKYIRQNENIHNKSIMIDYLNQLSDTLAKSLDDVRYFSNKLSLFKSVIKDSREIAQ
                     NIHRDHDIDNKEKYELLKKEYSNFLENCIRFSNEYLDILDIKNIFNIFDTKKIVLNLSY
                     YTKMWEVPDINNEQPINNNLQKFVDLKKKKYLNNVHWSKNKILKQLNEIEVKPVTLKDG
                     TSETERVAEWMYRNKTKVVYEIINKEFDDVYDLLNGMLKSEYTELMGYMRIWHNLSKNL
                     "
                     /name="hypothetical protein"
     gene            5008..5823
                     /locus_tag="HJI10_11545"
     CDS             5008..5823
                     /locus_tag="HJI10_11545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001832799.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QRJ03174.1"
                     /translation="MYFKNMDFLIDLYKNFNEVGIFAVIYIIYALIQILSQNILYKRQK
                     MERVKTLIINIILYIFITLVALMYLLAMIFYSLSAYPKEEVIKYITDWDKISLPAILLV
                     LYSLLFPIFIFPFVGKRRRKNYFAENVNNCIIEREIIDRVSINGRDKLILKDALGYQTE
                     KDITGIKDLKISTSQKKSWLTLEDIKIATMSLRDKQLLLKMIIGLIIFGVPTGYFVWNF
                     ISVVDDWDRIMHANDIFMYMGLFTLPLMVTVELYVVAFIITKNLFKKKK"
                     /name="hypothetical protein"
     gene            6373..6924
                     /locus_tag="HJI10_11550"
     CDS             6373..6924
                     /locus_tag="HJI10_11550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002488419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type III toxin-antitoxin system ToxN/AbiQ family
                     toxin"
                     /protein_id="QRJ03175.1"
                     /translation="MPQVDIEKRPNIWSLYFYTVGEIMKLYYVDEDYINELRNVDERVL
                     LNKSTRPYLGVVLSINDLNYFVPLSSPKENKKLNNQLSIKLFEVNNIQNRLGYLLFLNM
                     IPVPDKYLSKIDMQYIKEQDLEYYNLLTNQLIFIRQENQRIVNKAQKVYKNAVIKKVSF
                     FESMCVDYLALERYVKDLKQ"
                     /name="type III toxin-antitoxin system ToxN/AbiQ family
                     toxin"
     gene            complement(7192..7719)
                     /locus_tag="HJI10_11555"
     CDS             complement(7192..7719)
                     /locus_tag="HJI10_11555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002440835.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="QRJ03176.1"
                     /translation="MIKFEYFEEKDFDLLINWINSPELLVKWAGTDFNYPLDEEQLKEY
                     IKDTNKENSSKIIYKVIIEENNSKKIIGHIALNNIDFKNCSATLSKVLVGDPQMRGQGL
                     GPKIIKKLLKKAFEDLGLHRIELGVFAFNKSAIKSYKKIGFIKEGEKRDFRKLNGEYYN
                     LWQMSMLESEWS"
                     /name="GNAT family N-acetyltransferase"
     gene            complement(7912..8568)
                     /locus_tag="HJI10_11560"
     CDS             complement(7912..8568)
                     /locus_tag="HJI10_11560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002489266.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QRJ03177.1"
                     /translation="MNHNHEYHSNKPEIKANVVYRDGNIEITLEDEFNNAPLLDTMHEK
                     EMHFVLVSNDMEKYYHLHPQKKHEGLFIINQQLEPGTYQAFVDVTPKNHVYSVHPIELQ
                     IGDKITSTTSLNSDKNWVKVNKGVHVTLNSISAKEDEHVPLTFNTELTPQPYLGALGHV
                     IIFDEQLTDYIHVHPESPDSTTFYAHFPKKGMYKIWAEFKFNDEVHRFTYNIKVA"
                     /name="hypothetical protein"
     gene            complement(8632..8841)
                     /gene="copZ"
                     /locus_tag="HJI10_11565"
     CDS             complement(8632..8841)
                     /gene="copZ"
                     /locus_tag="HJI10_11565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001831373.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="copper chaperone CopZ"
                     /protein_id="QRJ03178.1"
                     /translation="MTNEVINVEGMSCDHCKHSIEKALNGLDGVTSSEVSLANGNVEVE
                     FDENQVAFNDFKEAIEDQGYDVIK"
                     /name="copZ"
     gene            complement(8875..11262)
                     /locus_tag="HJI10_11570"
     CDS             complement(8875..11262)
                     /locus_tag="HJI10_11570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002485948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="copper-translocating P-type ATPase"
                     /protein_id="QRJ03179.1"
                     /translation="MSENIKKTSLGITGMTCAACSNKVEKNLNKLDEVNANVNPSTEKA
                     TIEYNPNVTSLEDIANTIQKTGYGVLTEKVDLDVMGMTCAACSNKIEKVLNRISGVNKA
                     TVNLTTESATVEYNPDMTSVDEFQQRIKNLGYEAQPKKEASEKSSQKEKQLKRQLIKLV
                     VSAVLAAPLLMTMFVHLFGIQIPHIFMNPWFQFVLATPVQFVIGWQFYVGAYKNLRNGS
                     ANMDVLVALGTSAAFFYSIYESIKWLINTNYEPHLYFETSAVLITLILFGKYLEARAKT
                     QTTNALSKLLNLQAKEARILRNGEETMVPLSEVKEGDYLVIKPGEKIPVDGKIIKGMTS
                     IDESMLTGESIPVEKMQNDNVIGSTMNKNGAITVEATKVGKDTALASIVKVVEEAQGSK
                     APIQRLADIISGYFVPIVVGIAIFTFIIWISLVQPGQFEPALVAAIAVLVIACPCALGL
                     ATPTSIMVGTGKAAENGILFKGGEHIEGTHAINTVVLDKTGTITNGTPEVTDFSGDDQT
                     LQLLASAEKGSEHPLAEAIVSYAKEKSLEFLEVDHFEAIPGRGINATIDGKELFVGNRK
                     LMSEKGIQTNEAETNLAQFEKEGKTAMLISVDNELRGVVAVADTVKDTAQQAIQKLHEL
                     GIEVAMLTGDNKRTAQAIAKQVGIDTIIAEVLPEEKASKVAEIQSEGKKVAMVGDGVND
                     APALVKADIGIAIGTGTEVAIEAADITILGGDLLLIPKAIKASKSTIRNIRQNLFWAFG
                     YNVAGIPIAAIGLLAPWVAGAAMALSSVSVVTNALRLKRMKL"
                     /name="copper-translocating P-type ATPase"
     gene            complement(11277..11552)
                     /locus_tag="HJI10_11575"
     CDS             complement(11277..11552)
                     /locus_tag="HJI10_11575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001831396.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-sensing transcriptional repressor"
                     /protein_id="QRJ03180.1"
                     /translation="MNTTTVKNNDALLNRLKRLEGQMRGLQSMIAEDRYCIDVLVQITA
                     IQSALKQVGFIVTEDHISNCVSEGIKNGNGEESIKELMVVLKQFSK"
                     /name="metal-sensing transcriptional repressor"
     gene            11727..12002
                     /locus_tag="HJI10_11580"
     CDS             11727..12002
                     /locus_tag="HJI10_11580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002489264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutaredoxin family protein"
                     /protein_id="QRJ03181.1"
                     /translation="MDKNIQLELYTRPTCSDCQESKRYLNSKEISYSHKDVSQNLDLEE
                     EMKKISGNRIVPLFVFYKKIFWGKKKLFKYYVGFENNKKDILNILE"
                     /name="glutaredoxin family protein"
     gene            complement(12043..12984)
                     /locus_tag="HJI10_11585"
     CDS             complement(12043..12984)
                     /locus_tag="HJI10_11585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002449936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation transporter"
                     /protein_id="QRJ03182.1"
                     /translation="MENDHNHNHTHGANKKTLLISFIIITSYMIVEGLGGFFTNSLALI
                     SDAGHMLSDSISLGIALIAFTLGAKQANTNKTFGYKRFEILAAVLNGITLMLIAIYIFY
                     EAIERFKNPPEVASTGMLIIALVGLFINIIVAWIMLRGSDVEENLNMRGAYLHVISDML
                     GSIGAVIAALLIIFFRWGWADPLASVIVAILVLRSGFYVTKSSLHVLMEGAPSNINTKD
                     IIKTIKKFKEVKNIHDFHVWSVTSGLNALSCHIVVEDTMTITENEFLLKRIEHELNHQN
                     IQHVTIQTETSNNNHSEKLFCIVKEEDSQHHH"
                     /name="cation transporter"
     gene            complement(13347..13832)
                     /locus_tag="HJI10_11590"
     CDS             complement(13347..13832)
                     /locus_tag="HJI10_11590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002508772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="QRJ03183.1"
                     /translation="MKTVKEVSELLDVSKQTIHYHLKSLPSNLKVNKVGNKSLIDDNTI
                     DYLKTILNKKTTKESTKFDEKSTNKTESLNNQYSSYIDKYIEHLESEIRQKNRQIDDLT
                     IALKQEQSLNLNSQNILSNTKKIETDNIDSKEDIITPKASKKNEQKQSIFSKLFKKK"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(13851..14117)
                     /locus_tag="HJI10_11595"
                     /pseudo=""
     CDS             complement(13851..14117)
                     /locus_tag="HJI10_11595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002497232.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /name="replication initiation protein"
     gene            complement(14177..14851)
                     /locus_tag="HJI10_11600"
     CDS             complement(14177..14851)
                     /locus_tag="HJI10_11600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="QRJ03184.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            14895..15731
                     /locus_tag="HJI10_11605"
     CDS             14895..15731
                     /locus_tag="HJI10_11605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /protein_id="QRJ03185.1"
                     /translation="MQQNQDCAEILEYKQNRETGERKLYRVWFCKSRLCPMCNWRRAMK
                     HGIQSQKVVAEVIKQKPTVRWLFLTLTVKNVYDGEELNKSLSDMAQGFRRMMQYKKINK
                     NLVGFMRATEVTINNKDNSYNQHMHVLVCVEPTYFKNTENYVNQKQWIQFWKKAMKLDY
                     DPNVKVQMIRPKNKYKSDIQSAIDETAKYPVKDTDFMTDDEEKNLKRLSDLEEGLHRKR
                     LISYGGLLKEIHKKLNLDDTEEGDLIHTDDDEKADEDGFSIIAMWNWERKNYFIKE"
                     /name="protein rep"
     gene            15891..16661
                     /gene="aadD1"
                     /locus_tag="HJI10_11610"
     ARG             15892..16658
                     /name="aadD1"
                     /gene="aadD1"
                     /gene_name="aminoglycoside O-nucleotidyltransferase
                     ANT(4')-Ia"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            16878..17282
                     /gene="bleO"
                     /locus_tag="HJI10_11615"
     ARG             16879..17279
                     /name="bleO"
                     /gene="bleO"
                     /gene_name="bleomycin binding protein"
                     /tool="amrfinderplus"
                     /drug_class="BLEOMYCIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            17789..19051
                     /locus_tag="HJI10_11620"
     CDS             17789..19051
                     /locus_tag="HJI10_11620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001619005.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid recombination protein"
                     /protein_id="QRJ03200.1"
                     /translation="MSYAVCRMQKVKSAGLKGMQFHNQRERKSRTNDDIDHERTRENYD
                     LKNDKNIDYNERVKEIIESQKTGTRKTRKDAVLVNELLVTSDRDFFEQLDPGEQKRFFE
                     ESYKLFSERYGKQNIAYATVHNDEQTPHMHLGVVPMRDGKLQGKNVFNRQELLWLQDKF
                     PEHMKKQGFELKRGERGSDRKHIETAKFKKQTLEKEIDFLEKNLAVKKDEWTAYSDKVK
                     SDLEVPAKRHMKSVEVPTGEKSMFGLGKEIMKTEKKPTKNVVISERDYKNLVTAARDND
                     RLKQHVRNLMSTDMAREYKKLSKEHGQVKEKYSGLVERFNENVNDYNELLEENKSLKSK
                     ISDLKRDVSLIYESTKEFLKERTDGLKAFKNVFKGFVDKVKDKTAQFQEKHDLEPKKNE
                     FELTHNREVKKERSRDQGMSL"
                     /name="plasmid recombination protein"
     gene            19296..19481
                     /locus_tag="HJI10_11625"
     CDS             19296..19481
                     /locus_tag="HJI10_11625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001830207.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /protein_id="QRJ03201.1"
                     /translation="MCPNSSIYSDEKSRVLVDKTKSGKVRPWREKKIANVDYFELLHIL
                     EFKKAERVKDCGSVAK"
                     /name="protein rep"
     gene            complement(19522..20196)
                     /locus_tag="HJI10_11630"
     CDS             complement(19522..20196)
                     /locus_tag="HJI10_11630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="QRJ03188.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            complement(20263..21108)
                     /gene="blaZ"
                     /locus_tag="HJI10_11635"
     ARG             complement(20267..21108)
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            21215..22972
                     /gene="blaR1"
                     /locus_tag="HJI10_11640"
     ARG             21216..22969
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.83"
                     /coverage="100.0"
     gene            22962..23342
                     /gene="blaI"
                     /locus_tag="HJI10_11645"
     ARG             22963..23339
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.21"
                     /coverage="100.0"
     gene            23606..24184
                     /locus_tag="HJI10_11650"
     CDS             23606..24184
                     /locus_tag="HJI10_11650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="QRJ03192.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNQYGCEKIFSDHISGSRSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNNRGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRMAARARGRYGGRPEKLNKQDLTLLKTLYDNGTPI
                     KTIAEQWKVSRTTIYRYLNKLNNQENKDK"
                     /name="recombinase family protein"
     gene            24315..24923
                     /locus_tag="HJI10_11655"
     CDS             24315..24923
                     /locus_tag="HJI10_11655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002436987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="QRJ03193.1"
                     /translation="MIIGYARVSSIDQNLERQLDNLKTFGVEKIFTEKRSGKSVENRPV
                     FQEALNFVRMGDRFVVESIDRLGRNYDEVINTVNYLKDKEVQLMITSLPMMNEVIGNPL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIKVAKENGVYKGRPLLYSPNAKDPQKRI
                     IYHRVVEMLEEGQAISKIAKEVNITRQTVYRIKHDNNLV"
                     /name="recombinase family protein"
     gene            complement(25120..25686)
                     /gene="qacR"
                     /locus_tag="HJI10_11660"
     ARG             complement(25124..25686)
                     /name="qacR"
                     /gene="qacR"
                     /gene_name="multidrug-binding transcriptional regulator
                     QacR"
                     /tool="amrfinderplus"
                     /drug_class="QUATERNARY AMMONIUM"
                     /identity="99.47"
                     /coverage="100.0"
     gene            25864..27408
                     /gene="qac"
                     /locus_tag="HJI10_11665"
     CDS             25864..27408
                     /gene="qac"
                     /locus_tag="HJI10_11665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000622778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="QacA/B family quaternary ammonium compound efflux
                     MFS transporter"
                     /protein_id="QRJ03195.1"
                     /translation="MISFFTKTTDMMTSKKRWTALVVLAVSLFVVTMDMTILIMALPEL
                     VRELEPSGTQQLWIVDIYSLVLAGFIIPLSAFADKWGRKKALLTGFALFGLVSLAIFFA
                     ESAEFVIAIRFLLGIAGALIMPTTLSMIRVIFENPKERATALAVWSIVSSIGAVFGPII
                     GGALLDQFSWHSAFLINVPFTIIAVVAGLFLLPESKLSKEKSHSWDIPSTILSIAGMIG
                     LVWSIKEFSKEGLADIIPWVVIVLAITMIVIFVKRNLSSSDPMLDVRLFKKRSFSAGTI
                     AAFMTMFAMTSVLLLASQWLQVVEELSPFKAGLYLLPMAIGDMVFAPIAPGLAARFGPK
                     IVLPSGIGIAAIGMFIMYFFGHPLSYSTMALALILVGAGTASLAVASALIMLETPTSKA
                     GNAAAVEESMYDLGNVFGVAVLGSLSSMLYRVFLDISSFSSKGIVGDLAHVAEESVVGA
                     VEVAKATGIKQLANEAVTSFNDAFVATALVGGIIMIIISIVVYLLIPKSLDITKQK"
                     /name="qac"
     gene            27613..28173
                     /locus_tag="HJI10_11670"
     CDS             27613..28173
                     /locus_tag="HJI10_11670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001077893.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QRJ03196.1"
                     /translation="MNRADIFKIFDVELNITIFLGALVATFIYFISYMNNVNELITLCL
                     TLAFPAYLLKISRSFEVILLEEKIKNSKIKICDKDRIEREILVKKNLIDELLFPNRVIK
                     KYTLTILIYSIGIIILLLLCNMLSYGIGENVNFIWRLLACYVTSVTVIIVALIIMIMIF
                     DLIIGLLLNFQIFLKNKKYDDFL"
                     /name="hypothetical protein"
     gene            28249..28371
                     /locus_tag="HJI10_11675"
     CDS             28249..28371
                     /locus_tag="HJI10_11675"
                     /inference="COORDINATES: protein motif:HMM:NF019887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD hydrolase family protein"
                     /protein_id="QRJ03197.1"
                     /translation="MAPYTNKGYAVKELCSYLQINMDDVYTIGDRKLIYLCLIP"
                     /name="HAD hydrolase family protein"
     gene            complement(28500..28700)
                     /locus_tag="HJI10_11680"
     CDS             complement(28500..28700)
                     /locus_tag="HJI10_11680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002448025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid replication-associated protein"
                     /protein_id="QRJ03198.1"
                     /translation="MAGFLDNIDTSEVKYTENYKPVSKSTTMRVDTDIKKRLNQMALDK
                     DTSIKAIVDEVLGEFLEKNKY"
                     /name="plasmid replication-associated protein"
     gene            complement(28706..29500)
                     /locus_tag="HJI10_11685"
     CDS             complement(28706..29500)
                     /locus_tag="HJI10_11685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002448023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family protein"
                     /protein_id="QRJ03199.1"
                     /translation="MSIITVGNFKGGVGKTTVATLLSYIASENYDKKVLLIDFDPQGNA
                     TQIMKRTYPEFEEEKISFINMLKNGNIDQSIVKLTSKLSLLPADSSLANLSDIISKTDI
                     LKKRYILKNVVEKIKEIHDFDYIFIDVPPTINSDFTNNAVYASDYILMVFQTQQSAYES
                     SLSFVNFLRDRKKESDLSFELVGAVPVLIKKSGRVDKQILDMSKSAFSEALFENQIYQR
                     ERIKKFAADGIKDKDMHDKKVIYMFNKVYEELVNRIRLIEGE"
                     /name="ParA family protein"
     ARG             25865..27405
                     /name="qacB"
                     /gene="qacB"
                     /gene_name="quaternary ammonium compound efflux MFS
                     transporter QacB"
                     /tool="amrfinderplus"
                     /drug_class="QUATERNARY AMMONIUM"
                     /identity="99.22"
                     /coverage="100.0"
     ARG             15892..16661
                     /name="ANT(4')-Ia"
                     /gene="ANT(4')-Ia"
                     /gene_name="ANT(4')"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="99.21"
                     /coverage="101.19"
     ARG             complement(20264..21108)
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="95.02"
                     /coverage="100.0"
     Typing          2..936
                     /name="rep_cluster_2120"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.893"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          14909..15731
                     /name="rep_cluster_1018"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          17790..19048
                     /name="MOBV"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="96.19"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 atgtcaaaat tcaaaaaaat ttctgctagt gaatttgaaa catctcgttt ttaccaactc
       61 ccaaaatttt tatttgaaga tggtcatttt tctaaaatga caactgacgc aaaggttatg
      121 tatgctctat taaaagatcg ttttgaatta tccaaaatca ataactggat tgatgaagaa
      181 aataatatat atctactata tacaaataaa caattatgtt ccattttaca atacggagaa
      241 cctaaaatta tcaaattgaa aaaagagcta gaaaaattca atttaattat aaatgaaaga
      301 caaggactaa atagacctaa caaaatatac cttttagaac ctagttatga caaggaacta
      361 acaaatcgta agttccagaa caaacaaatt attagttcaa gaactaacga aaatatagtt
      421 caagaactaa caatttgtaa gtctaatgat actgatatta atgatactga gaataaagaa
      481 actgagaata atgatacgta tgatatgaat gatagtgaac atatagccaa ccctaatact
      541 tctcattcga atcatccaaa tcatcaatct aatgaatttg ataataatgc cttaaaatat
      601 catttacttc aagaaattcc cgatcaactt caaacctatt taaataactt tgaagttgat
      661 gaaatacaaa ttattaaaag tgtcatactt aaagctaaat catcatttaa taatgaaaag
      721 aatacagtat acatgttaga agatattgag tttgagatga ttaatgtgct caaacgtttt
      781 aaagcaacat taattcaaaa aagcgaaagt gtcgaagcca tgcaaggtta tttaatgcgt
      841 tcaattaaaa cagaactcga agaaatgcat tccttaaata tgcgacgtca aaacgcgcca
      901 caaaaccata tattcgacac atcacactat ttatgattga acgtatgtcg ccttgaatct
      961 aaatatttcg caaaaaaata cgtccgttgg ataatcaaat ttaaataaga tggatgatgt
     1021 tgtcgcgcat acatcactag atcttgaaat tctataaaat tgtgattttc aatcatatca
     1081 ataatgttat taaacacttc ggactgacct tgatctaata aaaattggtt taagtcaaaa
     1141 ccacaaccac tttcaatatc attgatatca taaagcgttt tatctgaatt agaggcatga
     1201 ataaaataat caaacatgcc cttaggagac ataataattt caatatgcct cggtgtattt
     1261 aagtgttgtt gaagtagttc agagacttga gaataacttt ttaaagaatc aaagaataaa
     1321 gcaccgtgtt tatgtgattt tttgattaat cccgttgatt gatctatatc ttgattgtgc
     1381 cacgggctta aaatataagg aatatgcatc tgttccaaaa tatcttgata gttagatggc
     1441 gtgctttctt catatattaa aaaagcccac ttattcgaac gcttatcttt cgtcatcatg
     1501 gacatccttt ctgtgattat tgattaatga tgccatgggg ggtcgtagta accccatggc
     1561 actgttaaga tacacatgcg ttgtgtttat cacttcgtgt accacaacgc atgtgtatct
     1621 taacgtttgt ggcctgcaaa ccatagataa cgatgatgac gttgaggttt tgaaaagtaa
     1681 taattcgggt gcatatgtgt aatttcttca tgaatttgag gttcaatctt ttttaatata
     1741 tcgtgagctt gctgtttccg gggaatttta attgccacac ggacttcatt ttgacgaaca
     1801 tcaacgagcg attttccaac cattttatta aagtattgct ggacagaatt tgttttactt
     1861 ttgccgttat tttgccaatc ctgagtcgtg tctgtgtcaa catcttgttt aagataatgt
     1921 cgtaaaacca ttgtgtgata aacagatttg atatgattcg tgagttgatc tttcaataaa
     1981 cgaatcatta aatcgataac tattaacatc aatgctaaga ctaataagta aaatgtaagt
     2041 tgatatacac catttgaaat gattgtgata tagtgtgtga cgtttcgcgt atcgataata
     2101 tcaatttgag acacaataaa gtttaatagg acaaagagtt tactaaccat aactgtcaaa
     2161 atagcgaaca ggaacaagta aatgataata tcatacacac gcatgaaata ggttttcctc
     2221 atcacaatac acctgctttc gtatagtaag tcggacataa caagggtaag acttgatagg
     2281 gagattcact atcaatcact tggattagac ctgtcccttt accaatgggt atcacaatac
     2341 cttctggatc taaatcgggg aataaaaatt gtgtggtttt tttattaata ttaccgattt
     2401 gaatcagcac attgagttgt tctctaacgg aaaccgggat ggtttgatga tcaaatcgtt
     2461 gagacaccag taataaatga actttggtgg cacgacctaa taaagcaatt tgagatagta
     2521 atgaaaagaa cgcgtcttta atggtcttat tcacaccttc agctaaagcg agcacttcat
     2581 caatcacaat ggttaggtga tcaaattgat agtctggatc gtcataaaga atggtttgtc
     2641 gttgttgaat aacttgaagg caatgactta agttttcatt aatttcagat aaaaaatcag
     2701 acttagatcg attttgatga gggtgaatca cagtaatatc atgaatacgt gcccaacggc
     2761 tcggtgtatc aaacttaggg tcaacaataa tgagttctga tatcggtttt aatacactta
     2821 gtaagtacgt cagcatataa gatttaccac tgcctgaatt acctgcgatc gctatagatg
     2881 taatgttttg atagtttaaa gttaattgtt tcatgatcgg aatttgttga ttcgttagag
     2941 acgacgtaaa acgatctaaa tcagaaatca ctaagcgttc tgatatccct tgttgccatg
     3001 ggaaaaacaa agcgcgttgc gtatgaatat cgtcggtatc cataggtacg aaatacgcag
     3061 aattctgttt taacaatgtg aatttgggat ataaagctgc actcgcaatg agaaatattt
     3121 tttgatataa gtcatcgtcc acaatatagc ctgcaggcag gcgaggaaga aagtaaaaac
     3181 cttcttccgt gaccttgcag gtgaaactat tggtataact ggtttcgcct tgcatcatgg
     3241 atcctagtgc catatttaag ctttgtagga gatattgttc gagctctttg gctgtcatta
     3301 tttaacctcc ttcagatctg aagctttgaa gtaaacatca taacggactt cacaagcttc
     3361 taaatgatca aaagtaatga cgctcatata attaggtaat gtcacttcat tttcgaattt
     3421 aactgtgaag ggcggtaagc cttcttgaac aaaccaggct ttatacgcaa taatttctcc
     3481 ggtaggctga ttattctcaa aacgctgttg cggataaagt tctgtactta agctataaat
     3541 gggtttttta ttatcaatat aattggaagc tatttcagtt gaatagccac cttttttgaa
     3601 attagattga attttcatgt gaaacatcct ttctatccta ttgatgcgca tcgtttagga
     3661 aatataaata gaattaatca aagatatctg tgattgatta aattttcgca aatgaagtga
     3721 taaaataata ggtgaaaaaa tttattcggt ttttggaggt aatagcgtga ttatcattaa
     3781 taacaaagga atcaatgact tagattttaa ttattggatg aataatcaat taactgatga
     3841 caatatcgaa gaaattttag aggggtctga tttaagtatg gaacaagaaa tttttaaaag
     3901 taattataaa aaattcttgg agatagatgg caaaaaggaa agatggtatt ctctggaaga
     3961 agctgcgtat attattaatg ggaattattt ttcaatttat gaggaagata gcaaaaagcg
     4021 aagtgtcaca acagactatg taaaaaataa aagtaatgat atcttaaata atatagaaaa
     4081 tggaacaaac caaaattgga ataaatatca ttacccacaa aaaaggaagt ttgcattcaa
     4141 aaaagtaaag tatgttaatg aagatatgat cgatgaaata ttaagagatg atgtaacaaa
     4201 acctgaaaaa ataaaacgag gtaatatatc aatcgaagag ttgctaccta atcaaaatag
     4261 aatagcaaaa tatattagac agaatgagaa tatacataat aaaagtataa tgatagatta
     4321 cctaaatcaa ttaagtgata cactggcaaa atcattagac gacgtacgtt atttttcaaa
     4381 taaactatca ttatttaaat ctgttattaa agattctaga gaaatagcac aaaatataca
     4441 tagggatcac gatatagata ataaagaaaa atatgaactt ctgaaaaaag aatatagtaa
     4501 ttttttagaa aactgtatac gtttttctaa tgaatattta gatatactag atatcaaaaa
     4561 tatttttaat atttttgata ctaagaaaat tgttttaaat ctgtcttatt atacgaaaat
     4621 gtgggaggtt cctgatatta ataatgaaca accgataaat aataatttac aaaagtttgt
     4681 tgatttgaaa aagaagaagt atttaaataa tgtacattgg agtaaaaata agatacttaa
     4741 acaattaaat gaaattgaag ttaaacccgt tactttaaaa gatggtacta gtgaaacaga
     4801 acgcgtggca gagtggatgt atagaaataa aacaaaagtt gtttatgaaa ttataaataa
     4861 agaatttgat gatgtttatg atttacttaa cggtatgttg aagtctgaat acacagaact
     4921 tatgggctat atgagaatat ggcataactt aagcaaaaat ttataagtct tagtaacctg
     4981 ttatacactt taattggagg agttaacgtg tatttcaaaa atatggattt cttgattgac
     5041 ctatacaaga attttaacga agtagggatt tttgcagtaa tatatattat atatgcgctt
     5101 attcaaattc taagtcaaaa tattttatat aaaagacaaa agatggaaag agtaaaaaca
     5161 ctgataatca atataatttt atacatattt ataacactag tagcattaat gtacttgtta
     5221 gcaatgattt tttattcact cagtgcatat cctaaagaag aagtgattaa atatataaca
     5281 gattgggata aaattagttt gccagctata ttacttgttc tttattcgtt attattccct
     5341 atttttatat ttccatttgt aggaaaacga cgtagaaaaa actattttgc agaaaatgta
     5401 aataattgta ttattgaaag agaaattata gatagagtga gtattaatgg tagagataaa
     5461 ttaattctaa aagatgcctt aggatatcag acagaaaaag atataacagg aataaaggat
     5521 ttaaaaatta gtacatctca aaaaaaatct tggttaacgt tagaagacat taaaatagct
     5581 acgatgagtc taagagataa acaattactg ttaaaaatga ttataggttt aataatattt
     5641 ggggtcccta cagggtattt tgtgtggaac ttcatcagtg tcgttgatga ttgggataga
     5701 ataatgcacg caaatgatat atttatgtat atgggtcttt tcacgttacc attaatggta
     5761 acagttgagt tatatgtagt tgcatttatt attaccaaaa atttatttaa aaagaaaaaa
     5821 tgataacaaa tttagattaa gagaaaataa cttatcaaag gtcgtatatt agaacatgat
     5881 atatatagtt cgcctatcta tcaagaatca atctagtcgc agagagggat cattactttg
     5941 ctaatcattt tcgttaattg gactataaca ttggttggtg gagaaatgta aaagactatt
     6001 attattgatt ttgtaggatt tttttggtta ataagtcttt tcttatacta tcaacaatac
     6061 ggtaattagc ttgtcaaagg attttactct ttccaatcaa ttgtggattt gtatcggtgt
     6121 agaaagtatt ttgtaccaag cgtctacctg ctttatttct aatgaaaaat cagttagtaa
     6181 atctttaatc atttttctct tagaaaacca atttgaacgg ttctgagaaa tataatataa
     6241 agataaaaaa ttgacatatg atttatacag tgctaaaatt taaaatgtat ataggagagg
     6301 tcttgccaca agtagacatt gaaaaaatag agagtccatg ctaaaagttg gaattgaaaa
     6361 aatggagagg tcttgccaca agtagacatt gaaaagcgac caaatatttg gtcgctttat
     6421 ttttatactg taggagaaat tatgaaatta tactatgttg atgaagatta tattaatgaa
     6481 ttaagaaatg tagatgagag agtattatta aataaatcca ctcgtcctta tttaggagtt
     6541 gtattatcta ttaatgatct taattatttt gtccccttaa gttcccctaa agaaaataaa
     6601 aaactaaata atcaactatc aataaaattg tttgaggtta ataatattca aaatagatta
     6661 ggatatctat tatttttaaa tatgatacct gttcctgata aatatctttc taaaatagat
     6721 atgcaataca taaaggagca agatttagaa tattataact tattaactaa ccaattaatt
     6781 tttattaggc aagaaaatca aagaatcgta aataaagccc aaaaagtata taaaaatgct
     6841 gtgataaaaa aagtttcatt ttttgaatca atgtgtgtag attatttagc attggaaaga
     6901 tatgtgaaag atttaaaaca gtaaaaaaga taattctgtc aataattccc ctcaacatac
     6961 tcagaagaat tttagtgtaa agtctttgta attgtctatc ttagttaatt agatgtttac
     7021 tattatttct atattaatat atagctaaaa ttaataaaat agaagtcatt agctgaatta
     7081 cttatgaatc aaaataaatt ttatatacaa aatgtcattt ttgagtacgc tctaaataaa
     7141 caaaaatagt cctcttatta aaataagagg actatttttg tttaaaatta ttcaagacca
     7201 ttcgctttct aacatactca tttgccataa attataatat tctccattta attttctaaa
     7261 gtctcttttt tctccttctt ttataaatcc aatctttttg taacttttaa tagctgattt
     7321 attaaaggca aaaacaccta attcaattct gtgtagtccc aaatcttcaa aagccttttt
     7381 caataatttc tttattattt tagggcctaa tccttggcca cgcatttgcg gatcacctac
     7441 taaaacttta cttaacgtgg cggaacaatt tttaaaatct atattattta aagcaatatg
     7501 acctataatt ttttttgaat tattttcttc aatgataact ttataaatta ttttactaga
     7561 attttcttta tttgtgtctt taatatattc ctttaattgt tcttcatcta ggggataatt
     7621 aaaatctgta cctgcccatt tgactaaaag ttcaggagag tttatccagt ttattaataa
     7681 atcaaaatct ttctcctcaa aatattcaaa cttaatcaat aaattactcc ttaaataata
     7741 ggttattaac tataaaaatt cagtgaatgt tgcaatataa acaaccacta caattttttg
     7801 atactttctt catcaacttt ctatcttaaa ttttcgattt tttataaagc gttttgtatt
     7861 atctaaataa ctctttacaa tttactgatt tttaagcttt tgctaataga tttatgcaac
     7921 tttaatatta taagtaaatc tatgcacttc atcattaaat ttaaattctg cccaaatttt
     7981 atacatccct tttttaggaa aatgagcata aaaggttgta gaatcaggtg attctgggtg
     8041 aacatgaata taatcagtta attgctcatc aaatataatc acatgtccta aagctcctaa
     8101 ataaggttgg ggagttaatt ctgtattgaa agttaaaggg acatgttcat cttctttagc
     8161 acttatagaa tttaaagtta catgaactcc tttgttaact tttacccaat ttttatcaga
     8221 atttaaagat gttgtagagg ttattttatc tccaatttgc agttcaatag gatgaacgga
     8281 atacacatgg ttttttggtg taacatcaac aaaagcctgg taagttcctg gctctaattg
     8341 ttggttaatt ataaataaac cttcatgctt tttttgaggg tgtaggtggt aatatttctc
     8401 catgtcatta gatactaaaa cgaaatgcat ttctttttca tgcatagtat ctaataatgg
     8461 ggcattatta aattcatctt ctaacgtaat ttctatatta ccatctctat atacaacatt
     8521 tgctttaatt tcgggtttgt ttgaatgata ttcatgatta tgattcatat ttttatcctc
     8581 cttaattttt aataagggca tatcattaaa cgatatgccc aactatttaa attatttaat
     8641 tacatcgtaa ccttgatctt caatagcttc tttaaagtcg ttgaaagcta cttgattttc
     8701 atcaaattca acttccacat tcccattcgc caagcttact tctgaagatg ttacaccatc
     8761 taatccattt aatgcttttt caattgaatg cttgcaatgg tcacagctca taccttctac
     8821 attaataact tcgttagtca atgttgtcac ctcctttcaa gaaatataag attcttataa
     8881 tttcatacgt tttagacgta aagcgtttgt gacaacactt acagaactta aagccattgc
     8941 tgctcccgca acccaaggtg ctagcagacc aattgctgct atagggatac ctgcaacatt
     9001 gtaaccaaac gcccaaaata gattttggcg aatattacga attgtagatt tacttgcttt
     9061 tattgctttt ggaattaata aaaggtctcc tcctaaaata gttatatcag cagcttcgat
     9121 tgcaacttct gtacctgtac caatggcaat accaatatct gctttaacta gtgctggagc
     9181 atcattgaca ccatctccaa ccatagctac ttttttacct tcagattgaa tttctgctac
     9241 tttagaagct ttttcttctg gtaaaacctc tgcaataatc gtgtctatac caacttgttt
     9301 tgctattgct tgtgcggtac gtttgttatc accagttaac atagcaactt caatacctaa
     9361 ttcatgaagt ttttgaatag cttgttgggc agtatcttta actgtatcag ctacagcgac
     9421 aacccctctc aattcgttat ctacgcttat aagcattgca gtttttcctt ctttttcaaa
     9481 ttgagcgaga tttgtttcag cttcattagt ttggattcct ttttcactca ttagttttcg
     9541 atttccgaca aaaagttctt taccatcaat tgttgcattt ataccgcgcc ctggtatagc
     9601 ttcaaaatgg tctacttcta aaaattctaa tgatttttct ttagcataac ttacgatagc
     9661 ttcagctagt gggtgttcag aacctttttc tgcactagct aacaattgta atgtttgatc
     9721 atctccacta aaatcagtga cttcaggtgt gccatttgtt atagtgccag ttttatctaa
     9781 aacaactgta ttaatagcgt gtgtaccttc aatgtgttct ccacctttaa atagaatgcc
     9841 attttcagca gcttttccgg tacccaccat tatagaagta ggcgtagcta agcctaacgc
     9901 acaaggacaa gcgataacta atactgctat tgcagcaact aaggctggtt caaattgtcc
     9961 cggctgaact aatgaaatcc atataataaa tgtgaaaatc gcgataccta caacgatagg
    10021 tacaaaatat ccagaaataa tatctgctag tctttgtatt ggcgctttag aaccttgcgc
    10081 ttcttcgaca actttaacaa tggaggcaag agctgtatct ttaccaactt ttgttgcttc
    10141 aacagtaatt gctccatttt tattcattgt tgatcctata acattatcat tttgcatttt
    10201 ttcaacagga atagattcac ctgtcaacat tgactcgtca attgaagtca tacctttaat
    10261 tattttgcca tctactggta ttttttctcc tggtttgata actaaatagt ctccttcttt
    10321 tacctcactt aaaggaacca tagtctcttc accgttgcgt aatatacgtg cttctttagc
    10381 ttgtaaattc aacaatttac ttaacgcatt tgttgtttgt gttttagcac gtgcttctaa
    10441 atactttccg aaaagaatta aagtaattaa tacagcactt gtttcaaaat ataggtgtgg
    10501 ctcataattt gtattaatta accacttaat cgattcataa atactataaa agaaggctgc
    10561 gcttgtacct aaagcgacaa gaacatccat atttgctgac ccattacgaa ggtttttata
    10621 agcgcctaca taaaattgcc aaccaataac aaattgaaca ggcgttgcta atacaaattg
    10681 gaaccacggg ttcataaata tatgtggtat ttgaatacca aataaatgaa cgaacattgt
    10741 cattaacaat ggagctgcta aaacagctga aacaactaat ttaattaact gtcgttttaa
    10801 ttgtttttct ttttgggaac ttttttctga tgcttctttt ttaggttgtg cctcataccc
    10861 taggttttta atacgttgtt gaaattcatc tacagacgtc atatcagggt tgtattctac
    10921 agtagcactt tctgtggtta aattaactgt agccttattt acacctgaga ttcgatttaa
    10981 aactttttcg attttattcg aacaagctgc acacgtcatt cccattacat cgagatccac
    11041 tttttcggtt aaaactccat aacctgtttt ttgaattgta tttgcaatat cttctaatga
    11101 tgtaacattg gggttatatt caattgtagc tttctctgta gaaggattta cattagcgtt
    11161 aacttcatct aatttattta gatttttttc tactttattc gagcaagctg cacatgtcat
    11221 gcctgtgata cctaatgagg tttttttaat attttcactc aattatttct ttcctcctat
    11281 tttgaaaatt gttttaatac aaccatcaat tctttgatac tttcttctcc gttgccattt
    11341 ttaatacctt cacttacaca attagatata tggtcttcag ttactataaa acccacttgt
    11401 tttagggctg attgtattgc tgttatttgt actagtacat ctatacaata tctatcttct
    11461 gctatcattg attgtaaacc gcgcatttgt ccttctaatc ttttgagtct attgagcaat
    11521 gcgtcattgt ttttaacagt agtagtgttc aatttcaccc ctcctcatat accctaacgg
    11581 ggtatctctt gttggaatct atattatacc cctagtaggt ataagtcaat acaaaagttt
    11641 catataaaaa attaatattt atagtttgtt ttaagaggta cacttgtata aaatgtatgc
    11701 taaaacttat attaggagag atatatttgg ataaaaatat acaacttgag ctttacacaa
    11761 gacctacatg ctctgattgc caagaatcaa aaaggtattt aaactctaaa gagattagtt
    11821 atagtcataa agatgtaagt caaaatttgg acttagaaga agaaatgaaa aaaatatcag
    11881 gcaaccgaat tgttccctta tttgtttttt ataaaaaaat tttttggggt aaaaaaaagt
    11941 tgtttaaata ttacgtggga tttgaaaata acaaaaaaga tatattaaat atattggaat
    12001 aattaaataa acagccatta ttaaaaaata atggctgttt atttaatgat gatgttgact
    12061 gtcttcttct ttcacgatac aaaacaattt ttcactatga ttattgttag aagtttcagt
    12121 ctgtattgtg acatgttgaa tattttgatg attgagttca tgttctatac gtttaagtaa
    12181 aaactcattt tcagtaatgg tcattgtatc ttctacaaca atatgacaag ataacgcgtt
    12241 taatccgcta gttactgacc aaacatgaaa gtcatgaata tttttaactt ctttgaattt
    12301 tttaatagtt ttaataatgt cttttgtatt tatattgctt ggtgctccct ccattaatac
    12361 atgaagactt gattttgtta cataaaagcc gctacgtagt actaaaattg ctacaatcac
    12421 acttgctaaa ggatccgccc acccccatct aaaaaatata atgagaaggg ctgctataac
    12481 tgcacctata gatccaagca tgtcgcttat tacatgcaaa tatgctccac gcatatttaa
    12541 gttttcttct acatcgctcc cgcgcagcat tatccaagcc acaataatat taataaacaa
    12601 gcctaccaag gcgataatta acatgcctgt agaagctacc tcaggggggt ttttaaatct
    12661 ctcaatagct tcataaaaaa tatagatagc tattaacatc aaagtaatac cattaagtac
    12721 agctgctagt atttcaaacc ttttgtagcc aaaagtttta tttgtattag cttgcttcgc
    12781 tcctaaagta aatgcaatta aagcaatacc taaagaaata gaatcactta acatatgacc
    12841 agcatctgaa attaacgcaa gactgttagt aaagaaacca cctaaccctt ctacaatcat
    12901 gtaacttgta ataataataa aactaattaa taaagtcttt ttgttcgcgc catgtgtatg
    12961 attatgattg tgatcgtttt ccatttaatc cctcctcttt ttaatgatga aaaatatttt
    13021 ctataatttg aatttttgtt tttataacta tagagttaaa aaatataaaa tttcaattaa
    13081 tgttttgtta ctcgaagaaa atcatactaa cttatgaata tatgctcata tattcataag
    13141 ttagtatgat ttttatcctt tgtcaatata gaaatgcttt gtattttgta tattaaataa
    13201 aaaccctact ttgctttgga cagtagtggg atttttgcat atgataaacc acacttcact
    13261 tgctaaatat taactatatt ataattaaca agtgataatt tctttttaga gaaaataatg
    13321 tattcacgcc tttaggcgtg aatacattat ttttttttga atagtttaga aaagatagat
    13381 tgtttttgtt catttttttt tgatgctttt ggagtaatga tatcttcttt tgaatctata
    13441 ttatcagttt ctattttttt ggtattactt aatatatttt ggctatttaa attcaaagat
    13501 tgttcttgtt ttaatgcaat tgttaaatcg tcaatttgtc gattcttttg tcgaatttct
    13561 gattctaaat gctctatgta tttatcgata taactgctat attggttatt taatgattct
    13621 gttttgtttg tcgatttttc atcaaatttt gtcgattctt ttgtcgtttt tttatttaaa
    13681 attgttttta gataatctat tgtattatca tctattaatg atttgttacc tactttgttt
    13741 accttcaaat ttgaaggtaa actttttaaa tgataatgaa ttgtttgttt agagacatct
    13801 aaaagttcag aaacttcctt tacagttttc atcaaataac tgggtctcct ttactttttc
    13861 attttttgta aaaacgcttg acgttcttct tctgtatacg cagatgtctt agatgtggtt
    13921 ggttcataag tgttattttt taaccattgt ggcgtcattt cacggcttat atattgtttt
    13981 ggtttgcctg tacttatcat attagattgt cgtttcgaat gaatacgttt ctcaggttca
    14041 aaagaaaatt ctaaccattc aatctttcgt ccttttttag ctttaatttt attaatattg
    14101 agatttttaa ataaaaaggg ttctgttgca aagtaaaaaa tatagctaat cactaatata
    14161 tcatgtcagt gttcgtttaa cttgctagca tgatgctaat ttcgtggcat ggggaaaatc
    14221 cgtagatctg aagagaccta cggttctttt tatatagagc gtaaatacat tcaatacctt
    14281 ttaaagtatt ctttgccgta ttgatacttt gatatcttgt ctttcttact ttaatatgac
    14341 ggtgatcttg ctcaatgagg ttattcagat atttcgatgt acaatgacag tcaggtttaa
    14401 gtttaaaagc tttaattatt ttagccattg ctgccttcgt tgaaggtgcc tgatctgtaa
    14461 ctaccttttg aggcttacca aattgtttaa tgagacgttt gataaacgca tatgctgaat
    14521 gattatctcg ttgcttacgc aaccaaatat ctaatgtatg tccctctgta tcaatggcac
    14581 gatataaata gctccatttt ccttttattt tgatatacgt ctcatcaata cgccatttgt
    14641 aataagcttt tttatgcttt ttcttccaaa tttgatataa aattggggca tattcttgaa
    14701 cccaacggta gatcgttgaa tgatgaacgt ttacaccacg ttctcttaat atttcagata
    14761 tatcacgata gctcaatgca tatcttagat agtagccaac ggctacagtg ataacatcct
    14821 tgttaaattg tttatatctg aaatagttca tacagaagac tcctttttgt taaaattaca
    14881 ttataaattc aactttgcaa cagaaccaag attgtgctga aatattagag tataaacaaa
    14941 atcgtgaaac aggcgaaaga aagttgtatc gagtgtggtt ttgtaaatcc aggctttgtc
    15001 caatgtgcaa ctggaggaga gcaatgaaac atggcattca gtcacaaaag gttgttgctg
    15061 aagttattaa acaaaagcca acagttcgtt ggttgtttct cacattaaca gttaaaaatg
    15121 tttatgatgg cgaagaatta aataagagtt tgtcagatat ggctcaagga tttcgccgaa
    15181 tgatgcaata taaaaaaatt aataaaaatc ttgttggttt tatgcgtgca acggaagtga
    15241 caataaataa taaagataat tcttataatc agcacatgca tgtattggta tgtgtggaac
    15301 caacttattt taagaataca gaaaactacg tgaatcaaaa acaatggatt caattttgga
    15361 aaaaggcaat gaaattagac tatgatccaa atgtaaaagt tcaaatgatt cgaccgaaaa
    15421 ataaatataa atcggatata caatcggcaa ttgacgaaac tgcaaaatat cctgtaaagg
    15481 atacggattt tatgaccgat gatgaagaaa agaatttgaa acgtttgtct gatttggagg
    15541 aaggtttaca ccgtaaaagg ttaatctcct atggtggttt gttaaaagaa atacataaaa
    15601 aattaaacct tgatgacaca gaagaaggcg atttgattca tacagatgat gacgaaaaag
    15661 ccgatgaaga tggattttct attattgcaa tgtggaattg ggaacggaaa aattatttta
    15721 ttaaagagta gttcaacaaa cgggccagtt tgttgaagat tagatgctat aattgttatt
    15781 aaaaggattg aaggatgctt aggaagacga gttattaata gctgaataag aacggtgctc
    15841 tccaaatatt cttatttaga aaagcaaatc taaaattatc tgaaaaggga atgagaatag
    15901 tgaatggacc aataataatg actagagaag aaagaatgaa gattgttcat gaaattaagg
    15961 aacgaatatt ggataaatat ggggatgatg ttaaggctat tggtgtttat ggctctcttg
    16021 gtcgtcagac tgatgggccc tattcggata ttgagatgat gtgtgtcatg tcaacagagg
    16081 aagcagagtt cagccatgaa tggacaaccg gtgagtggaa ggtggaagtg aattttgata
    16141 gcgaagagat tctactagat tatgcatctc aggtggaatc agattggccg cttacacatg
    16201 gtcaattttt ctctattttg ccgatttatg attcaggtgg atacttagag aaagtgtatc
    16261 aaactgctaa atcggtagaa gcccaaacgt tccacgatgc gatttgtgcc cttatcgtag
    16321 aagagctgtt tgaatatgca ggcaaatggc gtaatattcg tgtgcaagga ccgacaacat
    16381 ttctaccatc cttgactgta caggtagcaa tggcaggtgc catgttgatt ggtctgcatc
    16441 atcgcatctg ttatacgacg agcgcttcgg tcttaactga agcagttaag caatcagatc
    16501 ttccttcagg ttatgaccat ctgtgccagt tcgtaatgtc tggtcaactt tccgactctg
    16561 agaaacttct ggaatcgcta gagaatttct ggaatgggat tcaggagtgg acagaacgac
    16621 acggatatat agtggatgtg tcaaaacgca taccattttg aacgatgacc tctaataatt
    16681 gttaatcatg ttggttacgt atttattaac ttctcctagt attagtaatt atcatggctg
    16741 tcatggcgca ttaacggaat aaagggtgtg cttaaatcgg gccattttgc gtaataagaa
    16801 aaaggattaa ttatgagcga attgaattaa taataaggta atagatttac attagaaaat
    16861 gaaaggggat tttatgcgtg agaatgttac agtctatccc ggcattgcca gtcggggata
    16921 ttaaaaagag tataggtttt tattgcgata aactaggttt cactttggtt caccatgaag
    16981 atggattcgc agttctaatg tgtaatgagg ttcggattca tctatgggag gcaagtgatg
    17041 aaggctggcg ctctcgtagt aatgattcac cggtttgtac aggtgcggag tcgtttattg
    17101 ctggtactgc tagttgccgc attgaagtag agggaattga tgaattatat caacatatta
    17161 agcctttggg cattttgcac cccaatacat cattaaaaga tcagtggtgg gatgaacgag
    17221 actttgcagt aattgatccc gacaacaatt tgattagctt ttttcaacaa ataaaaagct
    17281 aaaatctatt attaatctgt tcagcaatcg ggcgcgattg ctgaataaaa gatacgagag
    17341 acctctcttg tatctttttt attttgagtg gttttgtccg ttacactaga aaaccgaaag
    17401 acaataaaaa ttttattctt gctgagtctg gctttcggta agctagacaa aacggacaaa
    17461 ataaaaattg gcaagggttt aaaggtggag attttttgag tgatcttctc aaaaaatact
    17521 acctgtccct tgctgatttt taaacgagca cgagagcaaa accccccttt gctgaggtgg
    17581 cagagggcag gtttttttgt ttcttttttc tcgtaaaaaa aagaaaggtc ttaaaggttt
    17641 tatggttttg gtcggcactg ccgacagcct cgcagagcac acactttatg aatataaagt
    17701 atagtgtgtt atactttact tggaagtggt tgccggaaag agcgaaaatg cctcacattt
    17761 gtgccaccta aaaaggagcg atttacatat gagttatgca gtttgtagaa tgcaaaaagt
    17821 gaaatcagct ggactaaaag gcatgcaatt tcataatcaa agagagcgaa aaagtagaac
    17881 gaatgatgat attgaccatg agcgaacacg tgaaaattat gatttgaaaa atgataaaaa
    17941 tattgattac aacgaacgtg tcaaagaaat tattgaatca caaaaaacag gtacaagaaa
    18001 aacgaggaaa gatgctgttc ttgtaaatga gttgctagta acatctgacc gagatttttt
    18061 tgagcaactg gatccaggag aacaaaaacg attttttgag gaaagttata aattattttc
    18121 cgaacgatat ggcaagcaaa atattgctta tgcaacagtt cataatgatg agcaaacccc
    18181 tcacatgcat ttaggtgttg tgcctatgcg tgatggaaaa ctgcaaggaa aaaatgtgtt
    18241 taatcgtcaa gaactgttat ggctacaaga taaattcccc gagcatatga aaaaacaggg
    18301 ttttgagttg aagcgtggtg aacgtggctc tgaccgtaaa catattgaga cagctaaatt
    18361 taaaaaacaa actttggaaa aagagattga ttttctagaa aaaaatttag cagttaaaaa
    18421 agatgaatgg actgcttata gcgataaagt taaatcagat ttagaagtac cagcgaaacg
    18481 acacatgaaa agtgttgaag tgccaacggg tgaaaagtcc atgtttggtt tgggaaaaga
    18541 aataatgaaa acagaaaaga aaccaaccaa aaatgttgtt atatcggagc gtgattataa
    18601 aaacttagtg actgctgcga gagataacga taggttaaaa cagcatgtta gaaatctcat
    18661 gagtactgat atggcgagag aatataaaaa attaagtaaa gaacatgggc aagttaaaga
    18721 aaaatatagt ggtcttgtag agcgatttaa tgaaaatgta aatgattata atgagttgct
    18781 tgaagaaaac aagtctttaa agtctaaaat aagcgattta aagcgtgatg tgagtttaat
    18841 ctatgaaagc actaaggaat tccttaagga acgtacagac ggcttaaaag cctttaaaaa
    18901 cgtttttaag gggtttgtag acaaggtaaa ggataaaaca gcacaattcc aagaaaaaca
    18961 cgatttagaa cctaaaaaga acgaatttga actaactcat aaccgagagg taaaaaaaga
    19021 acgaagtcga gatcagggaa tgagtttata aaataaaaaa agcacctgaa aaggtgtctt
    19081 tttttgatgg ttttgaactt gttctttctt atcttgatac atatagaaat aacgtcattt
    19141 ttattttagt tgctgaaagg tgcgttgaag tgttggtatg tatgtgtttt aaagtattga
    19201 aaacccttaa aattggttgc acagaaaaac cccatctgtt aaagttataa gtgactaaac
    19261 aaataactaa atagatgggg gtttctttta atattatgtg tcctaatagt agcatttatt
    19321 cagatgaaaa atcaagggtt ttagtggaca agacaaaaag tggaaaagtg agaccatgga
    19381 gagaaaagaa aatcgctaat gttgattact ttgaacttct gcatattctt gaatttaaaa
    19441 aggctgaaag agtaaaagat tgtggttctg ttgcaaagta aaaaatatag ctaatcacta
    19501 atatatcatg tcagtgttcg tttaacttgc tagcatgatg ctaatttcgt ggcatgggga
    19561 aaatccgtag atctgaagag acctacggtt ctttttatat agagcgtaaa tacattcaat
    19621 accttttaaa gtattctttg ccgtattgat actttgatat cttgtctttc ttactttaat
    19681 atgacggtga tcttgctcaa tgaggttatt cagatatttc gatgtacaat gacagtcagg
    19741 tttaagttta aaagctttaa ttattttagc cattgctgcc ttcgttgaag gtgcctgatc
    19801 tgtaactacc ttttgaggct taccaaattg tttaatgaga cgtttgataa acgcatatgc
    19861 tgaatgatta tctcgttgct tacgcaacca aatatctaat gtatgtccct ctgtatcaat
    19921 ggcacgatat aaatagctcc attttccttt tattttgata tacgtctcat caatacgcca
    19981 tttgtaataa gcttttttat gctttttctt ccaaatttga tacaaaattg gggcatattc
    20041 ttgaacccaa cggtagaccg ttgaatgatg aacgtttaca ccacgttccc ttaatatttc
    20101 agatatatca cgataactca atgcatatct tagatagtag ccaacggcta cagtgataac
    20161 atccttgtta aattgtttat atctgaaata gttcatacag aagactcctt tttgttaaaa
    20221 ttatactata aattcaactt tgcaacagaa ccatttagaa tattaaaatt ccttcattac
    20281 actcttggcg gtttcactta tcaacttatc atttggctta tcacttttat tgtctttatt
    20341 cgtaaaaatg actaaaacaa taggttcaga ttggccctta ggataaacaa aagcaacatc
    20401 atttctagaa gcatatgtta ttgcttgacc acttttatca gcaaccttac agtcttttga
    20461 aacaccgtct ttaattaaag tatctccgct tttattattt aacattaaat caagtaagaa
    20521 ttttttgttt tctttgctta attttccatt tgcgataagt ttatttaaag tcttaccgaa
    20581 agcagcaggt gttgaagtat cttttttgct ctttggtgaa tagtaattta attctatctc
    20641 atatctaact ggatttgtta ctttatctcc tagttctttt agacgttgtt taactttttt
    20701 gattccacca atttctttta taattttatt gtttgctgta ttatcactat atgccattga
    20761 agcctcaata agttctttta aagtgatatc ttttcctaca tatttttcta aaataggaga
    20821 ataagcaact atatcatctt tgttaatatg tattttttta tttaacttat tataaggtac
    20881 ttgttctaac aaaatagcac tatttatcgc ttttgaagtc gaagcatagg caaatctctt
    20941 atctgaatta aattttactt ccttaccact tttagtatct aaagcataaa caccaatatg
    21001 agcattatat tttttttcta aatcatttaa ctctttggca tgtgaactgt ttgaattaca
    21061 tgcacttaaa actaaagcaa ttgcaattaa aaatattaac tttttcaaaa taaaccctcc
    21121 aatattacag ttgtaatttt tacaaattaa taatattaca attgtaatat tggtgtcaat
    21181 tgtttattat aaataattga aagaaggtgt caaaatggct aaattactaa taatgagcgt
    21241 agtaagcttt tgttttatat ttctattgtt agtatttttt aggtatatat taaaacgcta
    21301 ttttaattat agtttaaatt ataaagtttg gtatctaact gtgcttgctg gattaattcc
    21361 ttttatccca attaaattct cttttataaa atttaataat gtgaataatc aatcgcccac
    21421 agttgaaagt aggtcacacg acttgaacca taacataaat accaccaaac ctgttcaaga
    21481 gttcacaaca gatatccata agtttaattg ggattcaatt gataatatct gcacagttat
    21541 ttggatagtt ttggttatta ttttaagttt taaatttttg aaatccttat tatatcttaa
    21601 atatttaaag agacagtcac tttatctaaa cgaaaatgaa aaaaataaaa tagatacgat
    21661 acttttcaac catcaatata aaaaaaatat tgtgattcga aaagcagaga ctattcaatc
    21721 tccaataact ttttggtatg ggaaatatat tattttgatt cctagttcat attttaaaag
    21781 tgtaattgac aaaagactaa aatatataat attgcatgaa tatgctcatg ctaaaaatag
    21841 agatacttta catttaatta tctttaatat cttctctatt gttatgagtt acaatccatt
    21901 aatacatatt gtaaaaagaa agataattca tgacaatgaa gtagaagccg atagatttgt
    21961 tcttaataat attaacaaaa atgaatttaa aacttatgcg gaatctatta tggactccgt
    22021 attaaatatt ccatttttta ataaaaatat attaagccat tcatttaatg gtaaaaagtc
    22081 attactcaaa agaagattaa ttaatataaa agaagccaat ttgaaaaaac agtccaaatt
    22141 aattccaatt tttatttgta tttttacttt tttgctcatg gtaattcaaa gccagttttt
    22201 gatggggcaa tccataactg attataatta taaaaagccc ttacagaacg atcaccaaat
    22261 tttagatgaa agtaaaaatt ttggttcaaa tagtggatct ttcgtcatgt acagcatgaa
    22321 gaaagacaaa tactatattt ataatgaaaa agaaagtaga aagagatatt ctcctgattc
    22381 aacttataaa atttatttag cgatgtttgg acttgaccat catatcataa gtgataaaaa
    22441 ttcacgtatg tcatggaatc ataaacatta tcctttcgag tcttggaata aggaacaaga
    22501 tttaaataca gcaatgcaaa attcagttaa ttggtacttc gaacgtatta gtaatcaaat
    22561 accaaagaac tatactgcgg ctcaactcaa gcaattaaat tatggtaatg aaaacttggg
    22621 aagttataaa agctattgga tggaagatag tttgaaaata tctaatcttg aacaagtaat
    22681 agtttttaaa aatatgatgg aacaaaataa ccattttagt aaaaaagcaa agaatcaatt
    22741 atcttcttca ttattgatta agaaaaatga aaagtatgaa ctgtatggga aaacaggtac
    22801 aggtatagta aacgggaagt ataataatgg gtggtttgta ggttacgtaa ttacaaatca
    22861 tgataagtat tattttgcta cacatttatc agatggaaac ccgtctggga aaaatgctga
    22921 attaatcagt gaaaaaatat taaaagaaat gggtgtttta aatggccaat aagcaagttg
    22981 aaatatctat ggctgaatgg gatgttatga atataatatg ggataaaaaa tcagtatcag
    23041 ctaatgaaat tgtagttgaa attcaaaaat ataaagaagt tagcgataaa acaattagaa
    23101 cattaatcac aagactatat aaaaaagaga ttataaaacg atacaaatca gagaatattt
    23161 atttttactc atcaaatatt aaagaagacg atattaaaat gaaaactgct aaaacttttc
    23221 ttaataaact gtatggaggg gacatgaaaa gtttagtgct aaattttgcg aaaaatgaag
    23281 aattaaataa caaagaaatt gaagaattgc gagacatttt aaatgatatt agtaaaaagt
    23341 aattagagat atgtttcaaa cattatacat atgtaaacta tacttgactc ttattaaatt
    23401 agttttgtta ataacattta aaatatatta gtaaagatga gagtgtacat aaaataacca
    23461 ttttctgtac actctctttt tatatctaga tatatagcta gtatacatat tttagtgttc
    23521 aataacccaa cagaaaatct atgttcataa atatggttag aattaagtta tggtacaatg
    23581 aaaatctaca taggaggttt gtattttgaa aataggttat gcaagagtct caactggttt
    23641 gcaaaatttg aatttgcagg aagatcgatt aaatcaatat ggttgtgaaa agatatttag
    23701 cgatcatata agtggatcaa gaagtaaacg tcctggttta gataaagcta ttgaatttgc
    23761 gaggtcagga gatacgattg ttgtttggag actagataga ttaggacgta acatggaaga
    23821 tttaatcaca ttagttaatg aacttaataa tcgaggcgtg agttttcata gtttagaaga
    23881 aaatataaca atggataaat caagttctac aggacaattg ttatttcatt tattcgcagc
    23941 atttgcagag tttgaacgta atttaatttt agaacgttct tcagcggggc gaatggcagc
    24001 tcgtgctaga ggacgctatg gaggtcgacc cgaaaaatta aataaacaag atttgacttt
    24061 actcaaaaca ctttatgata atggaacccc gattaaaact attgcagagc aatggaaagt
    24121 ttcacgtaca acaatctatc gttatctcaa taagttaaat aaccaagaaa ataaagataa
    24181 ataaaaaata ttactgagtt ttaagaaaga taaaagttag acaggataca ccctaatcat
    24241 acatatataa ttgttgaatt tatagcaact taaacgtatg attagggtgt atattaattg
    24301 tggagtgaaa atgaatgatt ataggctatg caagagtatc ttcgatagat cagaatttag
    24361 agagacagct agataatttg aaaacatttg gcgtagagaa aatatttaca gagaaacgat
    24421 cggggaaatc agtagaaaat agacctgtat ttcaagaagc acttaacttt gtgagaatgg
    24481 gcgatagatt tgtggtagaa tcgattgatc gcttaggtcg taattatgat gaagtgatta
    24541 acacagttaa ttatttaaaa gataaagagg ttcaattgat gattactagc ttacctatga
    24601 tgaatgaagt cattggcaat ccattattag ataaatttat gaaagaccta atcattcaaa
    24661 tattagcaat ggtttcagaa caagaacgaa atgaaagtaa acgtagacaa gcacaaggta
    24721 ttaaagttgc gaaagaaaat ggtgtatata aaggacgccc tctattgtac tcacctaatg
    24781 ctaaagatcc tcaaaaacgc attatttatc atagagttgt agaaatgtta gaagaaggtc
    24841 aagcaattag taagattgcg aaagaagtta atataacaag gcagactgtt tatagaatta
    24901 aacacgataa taatttggtt taataaactt tacttcgata caaatgagag cttctcacag
    24961 cgtctcaaaa cagatgatca taatctatta tgagctttta ataataaaac aagaaaagag
    25021 agcgtaaata tgcgctctct tttctcatta acatttgttt ttgaatatga acgtaattta
    25081 gaaataatat ttattggtat ttcaagaata tatatataat tatttactaa gtccatttaa
    25141 aaaaatttga gagaacttgt tcataagttt aattctttca ttaatatttt gttcatgtgt
    25201 aaaggtaaca attccattaa cagcgtttgc tgctatttta ctaacagcat taacatcatt
    25261 aatacaccat tcgccattta aattaccctc cttaaaaatt acatgataag catctatata
    25321 tttgttttct aatttattca ttttttcatt aatgctatta gttttataat attcagtgca
    25381 aaattcaatt attgcgtttt gaagtggata atagtattcg gttgttaaag atagttcatt
    25441 atataaataa aatttttctc tattagtttt acatttgatt tgttcctttt tccactgttc
    25501 ttgccattta gattcttcta tatttaaaat ttctaaaaat agattttctt ttgttttaaa
    25561 gtgataataa agattccctt tactactttc tgataattta acaatttctc cagtagtagt
    25621 ggcattatat ccatttttta taaataattc ctttgcgaca cctagtattt tatctttcaa
    25681 gttcatcacg cctttaatga gtattaagta ctatcaatga tagcacaaaa aattcaaaga
    25741 ataattgtat aacacaatac agccatttaa atttcgcaag attttttgtt gtaatatgta
    25801 aaaaaataga ttataatcct tatagaccga tcgcacggtc tataaggatt ggagggaact
    25861 taaatgattt cattttttac aaaaactact gatatgatga catcaaaaaa aagatggact
    25921 gcactagtag tattagctgt tagtttgttt gttgttacaa tggatatgac aatattaatt
    25981 atggctttac cggaattagt aagagagtta gagccttctg gtacccaaca gttatggata
    26041 gttgatatat actctcttgt tttagctggc tttataattc cattgagtgc ctttgctgat
    26101 aaatggggaa gaaaaaaagc attattaact ggatttgctt tatttggcct cgtttcatta
    26161 gctatatttt tcgcagaaag tgcagagttc gtaatagcta ttcgattttt acttggtatt
    26221 gcaggtgctt taataatgcc aactactctt tcaatgataa gagtaatttt tgaaaaccct
    26281 aaagaaaggg ccactgcatt agctgtatgg tcaatcgttt catcgatagg tgctgttttt
    26341 ggaccaatta tcggaggagc tttacttgat caattttcat ggcactcggc atttttaatt
    26401 aatgtaccgt ttacgataat agcagttgta gcaggtttat ttttattacc agagtctaag
    26461 ttatcaaaag aaaagtctca ctcgtgggat attccttcta caattttatc aattgcaggc
    26521 atgattggac tggtatggag tatcaaagaa ttttcaaaag aaggactagc agatattatt
    26581 ccatgggttg taatagtatt agcaattacc atgatagtga tatttgttaa acgtaattta
    26641 tcaagttctg atccaatgtt agacgtaaga ctttttaaaa agagatcatt ttcagctggt
    26701 acaattgctg catttatgac aatgtttgca atgacatctg ttttgttatt agcttcacaa
    26761 tggttacagg ttgtggaaga actttctcct tttaaagctg gcttatacct attacctatg
    26821 gcaataggag atatggtgtt tgcaccaatt gcacccggat tagcggcgcg atttggaccg
    26881 aaaatagtgt taccttccgg aattggaatt gcagccattg gcatgtttat tatgtatttc
    26941 tttggtcatc cattatcata ttctacaatg gctttagcat taattttagt tggagctggt
    27001 acggcttcac tagcagttgc atctgctcta ataatgttag aaacacctac atcaaaagca
    27061 ggtaatgcag ctgctgttga agagtctatg tatgaccttg gaaatgtttt tggtgtagca
    27121 gtacttggta gcctatcttc tatgctttat cgtgtatttt tagatatttc atctttttca
    27181 tcaaaaggta tagttggaga tttagctcat gtagctgaag aatctgtagt gggcgctgtc
    27241 gaagtagcta aagctacggg gataaaacag cttgcaaacg aggctgtaac atcatttaat
    27301 gatgcttttg tagcaactgc tttagtaggt gggattatca tgattatcat ttcaatagtt
    27361 gtctatttgt taattcccaa atcacttgat ataactaaac aaaaatagta ctaaacatat
    27421 atttttagat attgtagatt agtttatttt taaaattagt aatagttaaa aagtagaacc
    27481 attaatttta aatggttcta cttttttatt attaagtaaa attataaaag acaatttctt
    27541 aaattaataa tatgatatac ctatatctaa taatttatta gtattaataa accttgaaag
    27601 gatgattaac tgatgaatag agcagatatt tttaaaatat ttgatgtaga acttaatata
    27661 actatatttt taggagcact agtagcaact ttcatctatt ttataagtta catgaacaat
    27721 gtaaatgaat taattacatt atgcttaaca ttagcttttc ctgcatattt attaaaaatt
    27781 agcagatcgt tcgaggttat tttattagag gaaaaaataa aaaatagtaa aatcaaaatc
    27841 tgtgacaaag atagaattga acgagagata ctggtgaaaa agaacctaat agatgaacta
    27901 ttgtttccta atagagttat taaaaaatat acactgacaa ttttaattta cagtataggt
    27961 attattattc ttttactact ttgtaatatg ttaagttatg gaattggtga aaatgtcaat
    28021 tttatctgga gattactagc ttgttatgta acgagtgtca cagtgattat agttgccttg
    28081 attataatga taatgatatt tgatcttata attggattac tattaaattt tcaaatattt
    28141 ttaaaaaata aaaagtatga tgacttttta taattattcg atttatataa tgaaaaatta
    28201 aatgattaaa catagaaacc tcaaaacaaa ccatatttaa tagagtttat ggcgccttat
    28261 acaaataaag gctatgctgt taaagaatta tgtagctatc ttcagattaa tatggatgat
    28321 gtttatacta ttggcgatag aaaattgatt tacctatgtt taatacccta gataattctt
    28381 ctgataattt agtttttgtt agagtttaac ataactgatg attatcagaa gttatttaaa
    28441 ataagagtgt gtcattacag tctaaagtaa tgacacactc tttcaatata tatataatac
    28501 taatacttat ttttttccaa aaattctcct aacacttcat caactatagc ttttatagat
    28561 gtatccttat ctaatgccat ttgatttagt ctttttttta tatcagtgtc cactctcata
    28621 gtcgtacttt tagataccgg tttataattt tccgtatatt ttacctcaga tgtatctatg
    28681 ttatctaaaa atcctgccat aaatatcact caccctcaat taatctaatt ctattaacta
    28741 attcttcgta gactttgtta aacatatata taactttttt gtcatgcata tctttatctt
    28801 ttattccatc agcggcaaat ttttttattc tttctctttg atatatctgg ttctcaaaga
    28861 gtgcttcaga aaatgctgat ttagacatat ctaatatctg tttatctaca cgtccacttt
    28921 ttttaattaa tactggaaca gcgccaacca attcaaacga taaatctgat tctttttttc
    28981 gatcccttaa aaaattaaca aatgaaagac tactttcata agcagattgt tgtgtttgaa
    29041 ataccattaa aatgtaatca cttgcataaa cagcattatt agtgaaatca gagttaatag
    29101 taggtggtac atcaataaat atatagtcga aatcgtgaat ttctttaatt ttttcaacca
    29161 cattttttaa aatatatctt ttctttagaa tatctgtctt tgaaatgata tcggataagt
    29221 tagccaaaga tgaatcagct ggtaatagtg ataatttgga agttaatttc acaatacttt
    29281 gatctatatt tccatttttt agcatgttta taaatgaaat cttttcttcc tcaaattccg
    29341 gataagttct tttcataatt tgagttgcat ttccctgagg atcaaaatct attaaaagta
    29401 cttttttatc ataattttca gatgcaatat aagaaagtaa cgtggctact gttgttttac
    29461 ctacaccacc tttaaaattt ccaactgtta ttatgctcaa aataatacct cccatttact
    29521 atgtctttac tctttacatt agttcactat cctaattggg tttttgttac atgtaacatg
    29581 ttactattga aattattttt tttcaatctt tatttactat gtctttactc tttacattag
    29641 ttcactatcc taattgggtt tttgttacat gtaacatgtt actattgaaa ttattttttt
    29701 tcaatcttta tttactatgt ctttactctt tacattagtt cactatccta attgggtttt
    29761 tgttacatgt aacatgttac tattgaaatt actttttttc aatctttatt tactatgtct
    29821 ttactcttta cattagttca ctatcctaat tgggtttttg ttacatgtaa catgttactt
    29881 ataagaagtt acataattta ttgtttcttc ttttttactt tgttactatt aacttagatt
    29941 ttaataaagt aaaaagcgtt tagtcgttgg cccgactaaa cgctttaggt aataaacgct
    30001 aacatatata ctctaaatga tgcgttgttt atataataag tacatataat tatatagtat
    30061 aaacaatatg acttcaagaa tgagatatta ttaaatataa taacgcgtct tattacctct
    30121 atctaaatat gaaaaagaag aggtttatat t
//
