LOCUS       CP052944               24048 bp    DNA     circular BCT 09-FEB-2021
DEFINITION  Staphylococcus epidermidis strain HD75-1 plasmid pHD75-1_3, complete
            sequence.
ACCESSION   CP052944
VERSION     CP052944.1
DBLINK      BioProject: PRJNA546129
            BioSample: SAMN14732907
KEYWORDS    .
SOURCE      Staphylococcus epidermidis
  ORGANISM  Staphylococcus epidermidis
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 24048)
  AUTHORS   Both,A., Huang,J., Qi,M., Lausmann,C., Weisselberg,S., Buttner,H.,
            Lezius,S., Failla,A.V., Christner,M., Stegger,M., Gehrke,T.,
            Baig,S., Citak,M., Alawi,M., Aepfelbacher,M. and Rohde,H.
  TITLE     Distinct clonal lineages and within-host diversification shape
            invasive Staphylococcus epidermidis populations
  JOURNAL   PLoS Pathog 17 (2), e1009304 (2021)
   PUBMED   33544760
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 24048)
  AUTHORS   Both,A., Huang,J., Qi,M., Lausmann,C., Weisselberg,S., Buettner,H.,
            Lezius,S., Failla,A.V., Christner,M., Stegger,M., Gehrke,T.,
            Baig,S., Citak,M., Alawi,M., Aepfelbacher,M. and Rohde,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-APR-2020) Institute of Medical Microbiology, Virology
            and Hygiene, University Medical Center Hamburg-Eppendorf,
            Martinistr. 52, Hamburg, Hamburg 20246, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. v0.4.7
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 146x
            Sequencing Technology             :: Illumina; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/29/2020 14:36:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 2,526
            CDSs (total)                      :: 2,442
            Genes (coding)                    :: 2,393
            CDSs (with protein)               :: 2,393
            Genes (RNA)                       :: 84
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 61
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 36 of 49
            Pseudo Genes (incomplete)         :: 19 of 49
            Pseudo Genes (internal stop)      :: 21 of 49
            Pseudo Genes (multiple problems)  :: 19 of 49
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..24048
                     /organism="Staphylococcus epidermidis"
                     /mol_type="genomic DNA"
                     /strain="HD75-1"
                     /isolation_source="nose; prosthetic joint infection"
                     /host="Homo sapiens"
                     /db_xref="taxon:1282"
                     /plasmid="pHD75-1_3"
                     /geo_loc_name="Germany: Hamburg"
                     /lat_lon="53.33 N 10.1 E"
                     /collection_date="2018"
                     /collected_by="Institute of Medical Microbiology, Virology
                     and Hygiene, University Medical Center Hamburg-Eppendorf"
     gene            1..936
                     /locus_tag="HJI11_12440"
     CDS             1..936
                     /locus_tag="HJI11_12440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="QRJ00977.1"
                     /translation="MPNFEKYNLSQVKTERFYQLPKYLFEDAYFKKMSAEAKIMYALLK
                     DRFELSIQNEWVDKNNNIYFIFSNKHLCEYLGYAEQKIIKLKKELISFNLLTQERVGLN
                     KPNRLYLLKPNYDIKATHSKELPNSQFQNNEFGSSRTVNLSGQELPNSQSNDTENNDTD
                     YIKTENNDTNDLNDNKLTFPSNHTNHSNHNNLNFNNEALKFQLLEELPQSIQNYLSNFE
                     VAEIKLIKSVLLKAKTSFNNSIDAYYLLEDMEFEIVNVLKRFKATLIQKNESVEAMQGY
                     LMKSLKSEFAEVHTLNKRRDHLPITSLFNQ"
                     /name="replication initiator protein A"
     gene            complement(1161..1400)
                     /locus_tag="HJI11_12445"
     CDS             complement(1161..1400)
                     /locus_tag="HJI11_12445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002505615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3847 domain-containing protein"
                     /protein_id="QRJ00978.1"
                     /translation="MNDFKNLKKTNAAIEKAELRKHRLKNLDRKERAHRLIRKGAMLEK
                     YFECEHLSPDETEELLKIYANYINTNKPNKFKKK"
                     /name="DUF3847 domain-containing protein"
     gene            complement(1405..1686)
                     /locus_tag="HJI11_12450"
     CDS             complement(1405..1686)
                     /locus_tag="HJI11_12450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002489259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QRJ00979.1"
                     /translation="MSKIKQTDITKLSQLEQQIEQLKKQKKKQEEQLSNKIGDYFLNKL
                     DLNMINSSDELYKIMDKVIEEFNKYIEQNSSDENNENLTENKINQNSK"
                     /name="hypothetical protein"
     gene            1890..3812
                     /locus_tag="HJI11_12455"
     CDS             1890..3812
                     /locus_tag="HJI11_12455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002489263.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobA/MobL family protein"
                     /protein_id="QRJ00980.1"
                     /translation="MDKGYFMLRVTNINRATKNIVASASYRSDEALYSERTDEKIKFRN
                     HTVKPESMILTPQNAPEWTKDRQRLWNEVDKVEKNNAKTKNPRLAKEVLLSLPNDFDRE
                     VQTELTKDFIKSEFVDKGMVADISIHRDDINNPHAHVLLTQRPFNADGTWGKKTKTKTR
                     YDENGHAILNQNGNKVRKQERFADFDFKEVRKHWELKLNQYSEREQSLRRYDSRSFEDQ
                     GLEKIAEIPLTREEYRLEKNEQKRCEKEGIEYQPVTYYGQKNEQIRRYNRGEVSQIFSD
                     KEKEQAQNEIRLFIQNANEQVSKNEQSYSILFDRYQRDVGYSEAKETIKNTFDSASTFG
                     RKIQNDLLKNEIKRRQLKFYAKNYDENYQFRKEIESKGYSQQAFVNTVETNYKALLSEK
                     NKLESREEKRKEIYQSAKDVYLTESEKNHLIVQQMYPKSHHHFSHDEKAFIVDEAQKGN
                     IIKATHVQYLFKQNNNIPNDVLLEDTYKKASKDIFFSQRHLKNLEKDSFEYNVELQFIK
                     EKEKEIDSYKEHIDDDLRIDIGDKNFEKVKDQTPNEKVQLLIKLEKYNNVDQEEVIEKH
                     INQVDRNDHDNRIEHENEQTNHINLPTINASDFLMYYANETEKQNNINYQKKKKTQKRN
                     NQMRR"
                     /name="MobA/MobL family protein"
     gene            4090..4281
                     /locus_tag="HJI11_12460"
     CDS             4090..4281
                     /locus_tag="HJI11_12460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002489262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QRJ00981.1"
                     /translation="MKKKGELDITFIMSTVLNILFLAGLTFLVQSENLYILIPYTILIF
                     INAVYLVVKAMNITKNRA"
                     /name="hypothetical protein"
     gene            4514..4726
                     /locus_tag="HJI11_12465"
     CDS             4514..4726
                     /locus_tag="HJI11_12465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017174779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VraH family protein"
                     /protein_id="QRJ00982.1"
                     /translation="MSIKQISDYLLNKKWGWDDLIWLIFAIVIASMFTTPLLGVPIGIV
                     VYFLLFNISDETKEEAKKYDLKKKK"
                     /name="VraH family protein"
     gene            5303..5395
                     /locus_tag="HJI11_12470"
     CDS             5303..5395
                     /locus_tag="HJI11_12470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="QRJ00983.1"
                     /translation="MSLIFVSIIAPIISGCIVAIFTFWLNNRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            5690..6673
                     /locus_tag="HJI11_12475"
     CDS             5690..6673
                     /locus_tag="HJI11_12475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017000684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QRJ00984.1"
                     /translation="MPIKEIENIDFIAEENTFMKFIHREHNIFEKDNIKRERQTYIEIT
                     SVINKNQFKRVKSGSTSRESKKTRVLTEVFNNQFNTLNNFIKIISVKYQYHNVFQLSLG
                     DILSIPYYVIYSMEGEIKDMSLFLINKPGKIEEDQYSELKKSELLNIKQNYQIFTNHPS
                     NTYVIAMRKGERAIYKADYNVAIIQIQTALEVFITKFLERYYKLDQQLSDGKISNKLAG
                     GYRNIIKDQLLKIVRKLNLNNSYEIENCINQYIDNYYPMRNKIVHEGLSYSKDEALKFQ
                     AIVNDLIRLLVFNMKNAMMSDFSKEFNMYNIHNENINMESIKEKYK"
                     /name="hypothetical protein"
     gene            7125..8591
                     /gene="msr(A)"
                     /locus_tag="HJI11_12480"
     ARG             7126..8588
                     /name="msr(A)"
                     /gene="msr(A)"
                     /gene_name="ABC-F type ribosomal protection protein Msr(A)"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE/STREPTOGRAMIN"
                     /identity="99.8"
                     /coverage="100.0"
     gene            complement(8815..9423)
                     /locus_tag="HJI11_12485"
                     /pseudo=""
     CDS             complement(8815..9423)
                     /locus_tag="HJI11_12485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002474535.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /name="recombinase family protein"
     gene            complement(9550..10128)
                     /locus_tag="HJI11_12490"
     CDS             complement(9550..10128)
                     /locus_tag="HJI11_12490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="QRJ00986.1"
                     /translation="MKIGYARVSTGLQNLDLQEDRLNQYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNNRGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNKQDLKLLKTLYDNGTPI
                     KTIAEQWKVSRTTIYRYLNKLNNQENKDK"
                     /name="recombinase family protein"
     gene            complement(10490..11164)
                     /locus_tag="HJI11_12495"
     CDS             complement(10490..11164)
                     /locus_tag="HJI11_12495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="QRJ00987.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMAKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            11208..11399
                     /locus_tag="HJI11_12500"
     CDS             11208..11399
                     /locus_tag="HJI11_12500"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QRJ00976.1"
                     /translation="MQQNLTIALKQEQSLNLNSQNILSNTKKIETDNIDSKEDIITPKA
                     SKKNEQKQSIFSKLFKKK"
                     /name="hypothetical protein"
     gene            complement(11382..13067)
                     /locus_tag="HJI11_12505"
     CDS             complement(11382..13067)
                     /locus_tag="HJI11_12505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002500635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS1182 family transposase"
                     /protein_id="QRJ00988.1"
                     /translation="MYKNYNMTQLTLPMETSVLIPTNDISRHVNDIVETIHDNEFDEFR
                     HHRGATSYHPKMMLKVILYAYTQSVFSGRKIEKMLNDSIRMMWLSQNQKPSYKTINRFR
                     VNPKVDALLESLFIQFYSQCVKQNLIDDKAIFIDGTKIEANANRYTFVWKKSIQNHESK
                     MNEDSKALYHELVTNKIIPEIKKDHDNELTKEEIDLIGSHLDKEIEDLNQHINNEKCTK
                     TRKQIRLKRTKIKKYKKQINDYFERKYRYEFQKSILKDRNSYSKTDHDATFMRMKEDHM
                     KNGQLKPGYNLQIATNSQFVLSYNVYQNPTDTRTMIPFLNSIQETYGHLPEYIVADAGY
                     GSESNYKAIIDDFNRTPLITYGMFIKDKTKKYKSDIFNTQNWNYDEINDEFICPNNKRL
                     GFKRYAYRHDKYGYKRDFKLYECDDCSECPLKNQCMNFNSKTNKKIMKNYNWEYFKSQI
                     NKKLSEPETKNIYSQRKIDVEPVFGFMKAILGFTRMSVRGLNKVKRELGFVLMALNIRK
                     VVAQRAENNQKIYKKDNFYIISIEIVFFSLIQELYVPDSLFFFE"
                     /name="IS1182 family transposase"
     gene            complement(13353..14123)
                     /gene="fabI"
                     /locus_tag="HJI11_12510"
     CDS             complement(13353..14123)
                     /gene="fabI"
                     /locus_tag="HJI11_12510"
                     /EC_number="1.3.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002476543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-ACP reductase FabI"
                     /protein_id="QRJ00989.1"
                     /translation="MINLENKTFVIMGIANKRSIGFGVAKVLDQLGAKLVFTYRKDRSR
                     KELEKLLEQLNQEEPKLYQIDVQKDEDVVNGFAKIGEEVGNIDGVYHSIAFANIEDLRG
                     RFSETSREGFLLAQDISSYSLTIVAHEAKKIMPNGGSIVATTYLGGEFAVQNYNVMGVA
                     KASLEANVKYLAYDLGPDNIRVNAISAGPIRTLSAKGVGGCNTILKEIEERAPLRRNVD
                     QEEVGKTAAYLLSDFSSGVTGENIHVDSGFHAIK"
                     /name="fabI"
     gene            14758..15699
                     /locus_tag="HJI11_12515"
     CDS             14758..15699
                     /locus_tag="HJI11_12515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002449936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation transporter"
                     /protein_id="QRJ00990.1"
                     /translation="MENDHNHNHTHGANKKTLLISFIIITSYMIVEGLGGFFTNSLALI
                     SDAGHMLSDSISLGIALIAFTLGAKQANTNKTFGYKRFEILAAVLNGITLMLIAIYIFY
                     EAIERFKNPPEVASTGMLIIALVGLFINIIVAWIMLRGSDVEENLNMRGAYLHVISDML
                     GSIGAVIAALLIIFFRWGWADPLASVIVAILVLRSGFYVTKSSLHVLMEGAPSNINTKD
                     IIKTIKKFKEVKNIHDFHVWSVTSGLNALSCHIVVEDTMTITENEFLLKRIEHELNHQN
                     IQHVTIQTETSNNNHSEKLFCIVKEEDSQHHH"
                     /name="cation transporter"
     gene            complement(15740..16015)
                     /locus_tag="HJI11_12520"
     CDS             complement(15740..16015)
                     /locus_tag="HJI11_12520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002489264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutaredoxin family protein"
                     /protein_id="QRJ00991.1"
                     /translation="MDKNIQLELYTRPTCSDCQESKRYLNSQEISYSHKDVSQNLDLEE
                     EMKKISGNRIVPLFVFYKKNFWGKKKLFKYYVGFENNKKDILNILE"
                     /name="glutaredoxin family protein"
     gene            16190..16465
                     /locus_tag="HJI11_12525"
     CDS             16190..16465
                     /locus_tag="HJI11_12525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001831396.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-sensing transcriptional repressor"
                     /protein_id="QRJ00992.1"
                     /translation="MNTTTVKNNDALLNRLKRLEGQMRGLQSMIAEDRYCIDVLVQITA
                     IQSALKQVGFIVTEDHISNCVSEGIKNGNGEESIKELMVVLKQFSK"
                     /name="metal-sensing transcriptional repressor"
     gene            16480..18867
                     /locus_tag="HJI11_12530"
     CDS             16480..18867
                     /locus_tag="HJI11_12530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002485948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="copper-translocating P-type ATPase"
                     /protein_id="QRJ00993.1"
                     /translation="MSENIKKTSLGITGMTCAACSNKVEKNLNKLDEVNANVNPSTEKA
                     TIEYNPNVTSLEDIANTIQKTGYGVLTEKVDLDVMGMTCAACSNKIEKVLNRISGVNKA
                     TVNLTTESATVEYNPDMTSVDEFQQRIKNLGYEAQPKKEASEKSSQKEKQLKRQLIKLV
                     VSAVLAAPLLMTMFVHLFGIQIPHIFMNPWFQFVLATPVQFVIGWQFYVGAYKNLRNGS
                     ANMDVLVALGTSAAFFYSIYESIKWLINTNYEPHLYFETSAVLITLILFGKYLEARAKT
                     QTTNALSKLLNLQAKEARILRNGEETMVPLSEVKEGDYLVIKPGEKIPVDGKIIKGMTS
                     IDESMLTGESIPVEKMQNDNVIGSTMNKNGAITVEATKVGKDTALASIVKVVEEAQGSK
                     APIQRLADIISGYFVPIVVGIAIFTFIIWISLVQPGQFEPALVAAIAVLVIACPCALGL
                     ATPTSIMVGTGKAAENGILFKGGEHIEGTHAINTVVLDKTGTITNGTPEVTDFSGDDQT
                     LQLLASAEKGSEHPLAEAIVSYAKEKSLEFLEVDHFEAIPGRGINATIDGKELFVGNRK
                     LMSEKGIRTNEAETNLAQFEKEGKTAMLISVDNELRGVVAVADTVKDTAQQAIQKLHEL
                     GIEVAMLTGDNKRTAQAIAKQVGIDTIIAEVLPEEKASKVAEIQSEGKKVAMVGDGVND
                     APALVKADIGIAIGTGTEVAIEAADITILGGDLLLIPKAIKASKSTIRNIRQNLFWAFG
                     YNVAGIPIAAIGLLAPWVAGAAMALSSVSVVTNALRLKRMKL"
                     /name="copper-translocating P-type ATPase"
     gene            18901..19110
                     /gene="copZ"
                     /locus_tag="HJI11_12535"
     CDS             18901..19110
                     /gene="copZ"
                     /locus_tag="HJI11_12535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001831373.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="copper chaperone CopZ"
                     /protein_id="QRJ00994.1"
                     /translation="MTNEVINVEGMSCDHCKHSIEKALNGLDGVTSSEVSLANGNVEVE
                     FDENQVAFNDFKEAIEDQGYDVIK"
                     /name="copZ"
     gene            19174..19830
                     /locus_tag="HJI11_12540"
     CDS             19174..19830
                     /locus_tag="HJI11_12540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002489266.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QRJ00995.1"
                     /translation="MNHNHEYHSNKPEIKANVVYRDGNIEITLEDEFNNAPLLDTMHEK
                     EMHFVLVSNDMEKYYHLHPQKKHEGLFIINQQLEPGTYQAFVDVTPKNHVYSVHPIELQ
                     IGDKITYTTSLNSDKNWVKVNKGVHVTLNSISAKEDEHVPLTFNTELTPQPYLGALGHV
                     IIFDEQLTDYIHVHPESPDSTTFYAHFPKKGMYKIWAEFKFNDEVHRFTYNIKVA"
                     /name="hypothetical protein"
     gene            20023..20550
                     /locus_tag="HJI11_12545"
     CDS             20023..20550
                     /locus_tag="HJI11_12545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002440835.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="QRJ00996.1"
                     /translation="MIKFEYFEEKDFDLLINWINSPELLVKWAGTDFNYPLDEEQLKEY
                     IKDTNKENSSKIIYKVIIEENNSKKIIGHIALNNIDFKNCSATLGKVLVGDPQMRGQGL
                     GPKIIKKLLKKAFEDLGLHRIELGVFAFNKSAIKSYKKIGFIKEGEKRDFRKLNGEYYN
                     LWQMSMLESEWS"
                     /name="GNAT family N-acetyltransferase"
     gene            20747..21442
                     /locus_tag="HJI11_12550"
     CDS             20747..21442
                     /locus_tag="HJI11_12550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_501278.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="QRJ00997.1"
                     /translation="MDVLTVEHLTKKIGNKTILKDISLNLKRGQIVGLVGANGAGKTSL
                     MKVILGYSIYQEGNFEVIENKHKKSNVGALIENPGVYPFMSGYDNLKLLNETKNTQDID
                     TIVSQLKMDEYIHNKAKTYSLGMKQKLGIAIAFLNQPQLIILDEPMNGLDPRAVRDVRE
                     LIVKKAEEGVTFLISSHILSELVKITNSILIINKGKIVTETTEEELNQYKDNDLENVLL
                     SIIDKEDQS"
                     /name="ATP-binding cassette domain-containing protein"
     gene            21444..22214
                     /locus_tag="HJI11_12555"
     CDS             21444..22214
                     /locus_tag="HJI11_12555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002475893.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease subunit"
                     /protein_id="QRJ00998.1"
                     /translation="MGTLIKQECFKLFKKKSTFIIPIIIMLLMVVQAIISKNYDDVFSP
                     QSSIESAFSGFSWFIFLLIIQASTIISMEFYHGTIKNLLYRKYTRTSIIISKIITLILF
                     SLLYFIVSIVVGIILWAIFFNDINLLESKGDALSLLSKMLLTGLGTYVGTWLVLSITLL
                     ISCAMKSPGVSIAVGIVLYFATSILSGILTIVVDKWEWLKWNPISMMNIMVQIVDKNMK
                     KFTKLELHELFIGNIVYIIIFLIIVVFVFKKKNV"
                     /name="ABC transporter permease subunit"
     gene            complement(22841..23608)
                     /locus_tag="HJI11_12560"
     CDS             complement(22841..23608)
                     /locus_tag="HJI11_12560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002489261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="QRJ00999.1"
                     /translation="MRTIKMVADELGVTKQTIVNNAKSLNIAFEKENGINYIDDKDYLK
                     IIEKITKKESTIQNKESVKKELFGENTAKAEKNIYNNSNSSETLKTKVNELEKQIEIFE
                     TRAKNDEKYIENLTKQLDQQNSNVNTLNKLLENQQILALESNKKIQKLENQLEEERQLN
                     YSFDTATNNRQNINSQEATFTEESQNINQQQTKRQPTEVNYKDIAEEKKNDSTNEGELT
                     KEDKFVEETKSDPDDNREVEPPKKGFWSRFFGN"
                     /name="DUF536 domain-containing protein"
     ARG             7126..8591
                     /name="msrA"
                     /gene="msrA"
                     /gene_name="msr-type ABC-F protein"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; streptogramin
                     antibiotic; streptogramin B antibiotic"
                     /identity="99.39"
                     /coverage="100.0"
     Typing          2..936
                     /name="rep_cluster_1215"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.304"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          1891..3743
                     /name="MOBQ"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="97.573"
                     /coverage="97.0"
                     /evalue="0.0"
ORIGIN
        1 atgcccaatt ttgaaaaata caatttatca caagtaaaaa ctgaaaggtt ttatcaacta
       61 cctaaatatt tattcgaaga tgcatatttt aaaaaaatgt cggcggaagc caaaattatg
      121 tatgcgttat taaaagatcg ctttgaatta tccatccaaa atgaatgggt agataaaaat
      181 aataacattt actttatttt cagtaataaa catttgtgtg aatacttagg ttatgcagaa
      241 caaaaaatta taaaattaaa aaaagagtta ataagtttta atttactaac tcaagaacgt
      301 gttggcctta ataaaccaaa tagattatac ctattaaaac ctaattatga cattaaagcc
      361 actcatagca aggaacttcc aaattcacag ttccagaaca atgaatttgg aagttctaga
      421 actgtgaatt taagtggtca agaacttcca aattcacagt ctaatgatac tgagaataat
      481 gatactgatt atattaagac tgagaataat gatacgaatg atttgaatga taataaacta
      541 acttttccta gtaatcatac aaatcattca aatcacaaca atttaaactt taataatgaa
      601 gctttaaaat tccaattact cgaagaacta ccgcaaagta ttcaaaacta tctaagtaac
      661 tttgaagtag ctgaaattaa acttattaaa tctgtgttat taaaagccaa aacatccttc
      721 aacaattcta ttgatgcata ttatttatta gaagatatgg aatttgaaat tgttaatgtt
      781 cttaagcgct ttaaagctac attaattcaa aaaaatgaaa gcgttgaagc aatgcaaggg
      841 tacttaatga aatctcttaa atctgaattt gcagaagtac atacgcttaa taaacgacgt
      901 gatcatttac ccatcacttc tttatttaat caataataca acttcataag ccaacaatga
      961 ttcaattaga gaatatcttt aattagatgt tttcttaact gtaggctaac tttattttca
     1021 atgaaatgta cttaattaag taagtgggac taaaactttt cgattttagt cccattttta
     1081 taaacaatta tgattcattg ttactactat cagcaatttt ttctttttag tggaactcag
     1141 gtatttgtaa gcatgataaa ttacttcttt ttaaatttat ttggcttatt cgtattaatg
     1201 tagttggcat aaatctttaa caattcttct gtttcatcag gacttaaatg ctcacattca
     1261 aaatactttt caagcatggc gccttttcga ataagtctat gcgctctttc tttgcgatct
     1321 aaatttttta atctatgttt tcttaattca gctttttcaa ttgcagcatt tgtttttttg
     1381 agatttttaa aatcattcat cgtatcactt actattctgg ttaattttgt tttctgttaa
     1441 attttcgttg ttctcatcgc tgctattttg ttcaatatat ttattaaatt cttcaatgac
     1501 tttatccatg attttataca attcatcact agagttgatc atatttaaat caagtttgtt
     1561 taaaaaataa tcaccaattt tattagatag ttgttcttct tgttttttct tttgcttttt
     1621 caattgttca atttgttgtt ctaattgact taattttgta atatctgttt gtttgatttt
     1681 agacataaaa aactccttca gtttatctat ataaagtata tcataattca ttggtcaagt
     1741 cgctcattca tggtataata taaccagttc ttaagacact gcccatttac atgcaaatta
     1801 aaaattggca taaaagtggg caaccctacg ggttgatcgt tatagttccc acaggggttt
     1861 aaattcaaaa aaagagagga ggtaaaatca tggataaagg ttactttatg ttgagagtga
     1921 ctaacattaa tcgagcaact aaaaatatcg ttgcgtcagc atcgtatcgt tctgatgaag
     1981 cgttatatag tgaacgtaca gatgaaaaaa ttaagtttag aaatcatact gttaagcctg
     2041 aaagcatgat tttaactcct caaaatgcac ccgaatggac taaagataga cagcgtttat
     2101 ggaatgaagt cgataaagtc gaaaagaata atgcgaaaac gaaaaaccct agattagcaa
     2161 aagaagtatt attaagttta cctaatgatt ttgatagaga agtacaaaca gaattaacaa
     2221 aagattttat aaaaagtgag tttgtagaca aaggaatggt tgctgatatt tcaattcata
     2281 gagatgatat caacaatcca catgctcatg ttttactgac tcaaagacct tttaatgcag
     2341 acggtacttg ggggaaaaag acaaaaacga aaacacgata tgatgaaaac ggtcatgcga
     2401 ttttaaatca aaatggtaat aaagttagaa aacaagaacg ctttgccgat tttgatttca
     2461 aagaagttcg taagcattgg gaattaaaat taaatcaata ttcagaacgt gaacaaagtt
     2521 taagacgata tgatagtcgt tcttttgaag atcaagggtt agaaaaaatt gccgaaattc
     2581 cactgacaag agaagaatat cgactagaaa aaaatgagca aaaacgttgt gaaaaagagg
     2641 gtattgagta ccaacccgtt acttattacg gacaaaaaaa tgaacagatt agacgatata
     2701 atcgtggtga agtatcacaa atatttagtg ataaagagaa agaacaagca cagaatgaaa
     2761 ttagattatt tattcaaaat gctaacgaac aagtaagtaa aaatgaacaa agttattcta
     2821 ttttatttga tagatatcaa cgtgatgttg gctattcaga ggcgaaagaa acaattaaaa
     2881 atacgtttga tagtgcgtct acttttggtc gtaaaattca aaatgactta cttaaaaatg
     2941 aaattaagag acgtcaattg aaattctatg ctaaaaatta tgatgaaaat tatcagttta
     3001 gaaaagaaat tgaaagtaaa ggatatagtc aacaagcgtt tgttaatact gttgaaacta
     3061 actataaagc gttactcagt gagaagaata agttagaaag tagagaggaa aaacgtaaag
     3121 agatttatca atcagctaaa gatgtttatc taactgaaag tgaaaaaaat catctcattg
     3181 ttcagcaaat gtaccctaaa tctcatcatc attttagcca tgatgaaaaa gcatttattg
     3241 ttgatgaggc acaaaaaggt aatattataa aagccactca tgttcaatac ctattcaaac
     3301 aaaataacaa tattcctaat gatgtattgt tggaagatac ttataaaaaa gcgagtaaag
     3361 atattttctt tagtcaaaga catcttaaaa atttagaaaa agatagtttt gaatataacg
     3421 ttgagttgca atttattaag gaaaaagaaa aagaaattga tagttataaa gaacatattg
     3481 atgatgattt aagaatagat ataggcgata aaaactttga aaaagtcaaa gaccaaacac
     3541 ctaatgagaa agttcaatta ctcattaaac ttgagaaata taataatgtt gatcaagaag
     3601 aagttatcga aaaacatatt aatcaagtag atagaaatga tcatgacaat cgtattgaac
     3661 atgaaaatga acaaactaat cacattaatt taccaacgat aaatgctagt gactttctta
     3721 tgtactatgc gaacgaaact gaaaagcaaa acaatattaa ttatcagaaa aagaagaaga
     3781 cacaaaagag aaataatcaa atgagaagat aatagaaggc tagatttaaa caaagtttat
     3841 tttttagtaa taagaaacca aacccaatag ggtatcttgt ctttaattta atgataacat
     3901 ttgaaattca tgatgatata tgaaatttta atttagtaat tgattgcaga tgaatatcga
     3961 gatggcgtga gctattaagc cgaccattcg acaagttttg agtttgttaa aggtttcgag
     4021 gctcaacgtc aataaagcaa ttggaataaa gtaactaggg taaaattttt aaaaaaggag
     4081 agaaatattt tgaagaaaaa aggtgagtta gatataactt ttattatgtc taccgttttg
     4141 aacattttat ttttagctgg gttaactttc ttagttcaat cagaaaattt atatatttta
     4201 attccataca ctattttgat ttttataaat gcggtttatc tagttgttaa ggctatgaat
     4261 attactaaaa atagagcatg acatttaggt taatttgaaa cgattttctt tttgtcttga
     4321 aacatacagg gataacgttc tttttttaaa atagggatag atattgatgt atctacgttt
     4381 gtccctgctg tttacgtttt aagagccata aatttatttt tatataaacc tcagtatcta
     4441 aaaattgtaa ataagggtat tttaaattta aaaaagagct gagataaatt ttgtaagaag
     4501 gagtgtttat attatgtcga ttaaacaaat atcggattat cttttaaata aaaagtgggg
     4561 ttgggatgac ttaatttggt taatttttgc gattgttata gcaagtatgt ttacaactcc
     4621 attattaggt gtgccaattg ggattgtagt ttatttttta ttgtttaata ttagcgatga
     4681 aactaaagaa gaagcaaaaa agtatgattt gaaaaagaaa aaatagaaca tgcatttata
     4741 atgataaaaa ttattgttgt tgagatgtct ccctaaacta aacttgcaaa ctaatgtcag
     4801 catagcaaga gttatgaggc agttattcaa taagtttaag gattgttaag ggttctgagg
     4861 atcaacgtca ataaagtatt tggaataaag tgaaaatttt gaaataatat aaatgttgag
     4921 aggtgattta ttattcaaaa taacagaatt gatattaata atctcagtac atttcatcgt
     4981 atttcgtttg ttatgaatat tttcttttta atttttatgg ctccaattta taatctggat
     5041 aatgtctatt tatcagttgc ttggactatt ttgggtttag caaatggtgt ttatttaata
     5101 gttaaacaaa gatatggaaa tactaataag cgtatttgac gtactgataa aaaagaacct
     5161 aaacacaggt tcttttttta ttttgagtat ttttcacata aaatgactta tcggaagtag
     5221 atatgctaaa taattcacag atggtataat gatggcgtcg ccttaacttc cggcggtatt
     5281 ttcggcggaa ggaggtgaaa tcatgagttt aatatttgtt agcataattg cacccataat
     5341 atcagggtgt atagttgcga tttttacgtt ttggctaaac aatcgcaata aataataagg
     5401 cgacaaagcc tcaccatcaa aagaaccccc aatctacagc catagattgg gggttcggtg
     5461 attcatgagt ctaatatttg ttaaatgtat tataacacca cagtgcgtag gaatgcaaag
     5521 ttatgtttta aataaatact tttaaatgta gaaaggggaa atacatgttg gataaagtta
     5581 agataaaaga agagtttaaa atgttgaaaa atgaaattta tacaaaaaaa gttttagagg
     5641 aagcaaaaaa aggcaattaa taacatttaa atacttatta ccttttagaa tgcccataaa
     5701 agaaattgaa aatattgact ttatagctga agaaaataca tttatgaaat tcattcatag
     5761 agaacacaat attttcgaaa aagataacat taaaagagag agacaaacat atattgaaat
     5821 cacttcagtt attaataaaa atcaatttaa aagagtaaaa tctggatcta cttctagaga
     5881 gtctaaaaaa actagagttt taactgaagt ttttaataac caatttaata cccttaataa
     5941 tttcattaaa attatcagtg tgaagtatca gtaccacaat gtttttcaac tgtctcttgg
     6001 tgatatatta agtattccat attatgtcat atacagtatg gaaggtgaga taaaagatat
     6061 gagtcttttt cttataaata aaccgggtaa aatagaagaa gatcaatatt cagaattgaa
     6121 aaaaagtgaa ttattaaata ttaaacaaaa ctatcaaatt ttcactaatc accctagtaa
     6181 tacatatgta atagctatga gaaaaggtga aagagcaatt tataaggctg attacaatgt
     6241 agcaattata caaattcaga ctgcattaga agtttttatt actaagtttt tagagagata
     6301 ttataaatta gaccaacagc taagtgatgg aaaaattagc aataagcttg caggtggcta
     6361 cagaaatatt attaaggatc aattattaaa aatagtaaga aaattaaatt taaataattc
     6421 ttatgagatt gaaaattgca taaatcaata tattgataac tattatccta tgagaaataa
     6481 aattgttcat gaaggtctat cttatagtaa agacgaggcg ttaaaattcc aagctatagt
     6541 aaatgattta attagactat tagtatttaa tatgaaaaat gcaatgatga gcgatttttc
     6601 taaagaattt aatatgtata atattcataa tgaaaatatt aatatggaaa gtataaaaga
     6661 aaaatacaaa taaatataaa actaggataa agagattaca tatattgtta gtttcgagta
     6721 cactctaaat taacaagatg tataatcaat ctcaaattgt aattttatac ttttattata
     6781 taatctttgt acttagagat atattgtaaa aaaaccaata aaatgttata ttaacattac
     6841 tattttatcg atgaaggagg attaaaatga cagcttctat gagactcaaa taaacctttt
     6901 tgaatacaaa actaaattaa ttcaaaaagg cttgtccgca atacacacac tcataggatg
     6961 acttatgtca ttttttatcc ttcgatagga ataataaacg ctttcaaata ctaaaacatc
     7021 gtaataattc tttaagtgtt tgaaagtgta atgtgaatga gacgggagta gcctgtctca
     7081 ttttttgcgt acacgtcctt taaatataca aggagtgtat aaatatggaa caatatacaa
     7141 ttaaatttaa ccaaatcaat cataaattga cagatttaca atcacttaac atcgatcatc
     7201 tttatgctta ccaatttgaa aaaatagcac ttattggggg taatggtact ggcaaaacca
     7261 cattactaaa tatgattgct caaaaaacaa aaccagaatc tggaacagtt gaaacgaatg
     7321 gcgaaattca atattttgaa cagcttaaca tggatgtgga aaatgatttt aacacgttag
     7381 acggtagttt aatgagtgaa ctccatatac ctatgcatac aaccgacagt atgagtggtg
     7441 gtgaaaaagc aaaatataaa ttagctaatg tcatatcaaa ttatagtccg atattacttt
     7501 tagatgaacc tacaaatcac ttggataaaa ttggtaaaga ttatctgaat aatattttaa
     7561 aatattacta tggtacttta attatagtaa gtcacgatag agcacttata gaccaaattg
     7621 ctgacacaat ttgggatata caagaagatg gcacaataag agtgtttaaa ggtaattaca
     7681 cacagtatca aaatcaatat gaacaagaac agttagaaca acaacgtaaa tatgaacagt
     7741 atataagtga aaaacaaaga ttgtcccaag ccagtaaagc taaacgaaat caagcgcaac
     7801 aaatggcaca agcatcatca aaacaaaaaa ataaaagtat agcaccagat cgtttaagtg
     7861 catcaaaaca aaaaggcacg gttgagaagg ctgctcaaaa acaagctaag catattgaaa
     7921 aaagaatgga acatttggaa gaagttgaaa aaccacaaag ttatcatgaa ttcaattttc
     7981 cacaaaataa aatttatgat atccataata attatccaat cattgcacaa aatctaacat
     8041 tggttaaagg aagtcaaaaa ctgctaacac aagtacgatt ccaaatacca tatggcaaaa
     8101 atatagcgct cgtaggtgca aatggtgtag gtaagacaac tttacttgaa gctatttacc
     8161 accaaataga gggaattgat tgttctccta aagtgcaaat ggcatactat cgtcaacttg
     8221 cttatgaaga catgcgtgac gtttcattat tgcaatattt aatggatgaa acggattcat
     8281 cagaatcatt cagtagagct attttaaata acttgggttt aaatgaagca cttgagcgtt
     8341 cttgtaatgt tttgagtggt ggggaaagaa cgaaattatc gttagcagta ttattttcaa
     8401 cgaaagcgaa tatgttaatt ttggatgaac caactaattt tttagatatt aaaacattag
     8461 aagcattaga aatgtttatg aataaatatc ctggaatcat tttgtttaca tcacatgata
     8521 caaggtttgt taaacatgta tcagataaaa aatgggaatt aacaggacaa tctattcatg
     8581 atataactta aaaactatac actaatttat attgaatatt tctttaaagt attataataa
     8641 agtaaataac aatagtacca taaccgatca tttttgagaa aaagaatata gaagaaaaga
     8701 gagggagttt ttaccctctc ttttcttgtt ttattattaa aatctcataa tagatgatta
     8761 atatgcgttt tagaacgctg tgagaaacgc tcatttgcat tgacaaccta tttatcaaga
     8821 taatccctta tcgtgtttaa ttctataaac agtctgcctt gttatattta cttcttttgc
     8881 aattttacta attgcttggc cttcttctaa catttcgaca actcgatgat agataacacg
     8941 cttttgagga tctttcgcgt ttggcgaata aagtaaaggt cgtcctttat aaacgccttt
     9001 ttcttttgca acttgaattc cttgtgcttg tcgacgttta ctttcgtttc tctcttgttc
     9061 tgaaaccatt gctaaaattt gaacaattaa atctttcata aatttatcca gtaatggatt
     9121 actaataact tcattcatca taggtaaact tgtaatcatt aactgaacgt ctttttcttt
     9181 taagtaattc acagtttcaa taatttcatc ataattacgt cctaaacgat caatagattc
     9241 cacaacgaat cgatctcccg ttcttacaaa gttaagtgct tcttgaaata ctggtctatt
     9301 ttcaatagat ttcccagact gtttttctgt aaatattttt tcagccccaa acgtctttaa
     9361 attttcaagt tgtctttcta aattttgatc gatcgatgat actcacgcat agccaacaat
     9421 cattgatttt cacctcataa ttaatataca ccctaaccat acattttagt tgctataaat
     9481 tcaacaatta tacatgtatg attagggtgt atcctgtcta atttttatct ttcttaaaat
     9541 ttagtaatat tatttatctt tattttcttg gttatttaac ttattgagat aacgatagat
     9601 tgttgtacgt gaaactttcc attgctctgc aatagtttta attggtgttc cattatcata
     9661 aagtgttttg agtaatttta aatcttgttt atttaatttt tcgggtcgac ctccatagcg
     9721 tcctctagca cgagctgcaa ttcgtcctgc tgaagaacgt tctaaaatta aattacgttc
     9781 aaactctgca aatgctgcga ataaatgaaa taacaattgt cctgtagaac ttgatttatc
     9841 cattgttata ttttcttcta aactatgaaa actcacgcct cgattattaa gttcattaac
     9901 taatgtgatt aaatcttcca tgttacgtcc tagtctatct agtctccaaa caacaatcgt
     9961 atctcctgac ctcgcaaatt caatggcttt atctaaacca ggtcgcttac tttttgaacc
    10021 actcatatga tcattaaata tcttttcaca accatattga tttaaccgat cttcctgtaa
    10081 atccaagttc tgtaatccag ttgaaactct tgcataacct attttcaaga tacaaacctc
    10141 ctatatacat tttcattgta tcataactta attctaacca tatttatgaa catagatttt
    10201 ctgttgggtt attgaacact aaaatatgta taatagatat atatctagat ataaaaagag
    10261 agtgtccaga aaatggttat tttctgtaca cgctttaatc taatcaactt tcgtatactt
    10321 tcaatgtact cttaagttct ttgactagca tattccttaa ttgaattggg gattttattt
    10381 ttacatcttt tccaaatgtt aaaaacagag atttcaaata ttctaattct ggttctgttg
    10441 caaagtaaaa aaatatagct aaccactaat ttatcatgtc agtgttcgct taacttgcta
    10501 gcatgatgct aatttcgtgg catggcgaaa atccgtagat ctgaagagac ctgcggttct
    10561 ttttatatag agcgtaaata cattcaatac cttttaaagt attctttgct gtattgatac
    10621 tttgatacct tgtctttctt actttaatat gacggtgatc ttgctcaatg aggttattca
    10681 gatatttcga tgtacaatga cagtcaggtt taagtttaaa agctttaatt actttagcca
    10741 ttgctacctt cgttgaaggt gcctgatctg taattacctt ttgaggttta ccaaattgtt
    10801 taatgagacg tttgataaac gcatatgctg aatgattatc tcgttgctta cgcaaccaaa
    10861 tatctaatgt atgtccctct gcatcaatgg cacgatataa atagctccat tttcctttta
    10921 ttttgatgta cgtctcatca atacgccatt tgtaataagc ttttttatgc tttttcttcc
    10981 aaatttgata caaaattggg gcatattctt gaacccaacg gtagaccgtt gaatgatgaa
    11041 cgtttacacc acgttccctt aatatttcag atatatcacg ataactcaat gcatatctta
    11101 gatagtagcc aacggctaca gtgataacat ccttgttaaa ttgtttatat ctgaaatagt
    11161 tcatacagaa gactcctttt tgttaaaatt atactataaa ttcaactttg caacagaacc
    11221 taacaattgc attaaaacaa gaacaatctt tgaatttaaa tagccaaaat atattaagta
    11281 ataccaaaaa aatagaaact gataatatag attcaaaaga agatatcatt actccaaaag
    11341 catcaaaaaa aaatgaacaa aaacaatcta tcttttctaa actattcaaa aaaaaataat
    11401 gagtccggga cataaagttc ttggataagt gaaaaaaaga caatttctat tgaaataata
    11461 tagaaattgt cttttttata aattttttga ttattttcag ctcgttgagc tactactttt
    11521 cttatattaa gtgccattaa tacaaaacca agttctcttt tgactttatt gagtcctcgg
    11581 acagacatcc gagtgaaacc caaaatagcc ttcataaatc caaaaacagg ttccacatca
    11641 atttttcttt gactgtagat attttttgtt tctggttctg aaagcttttt gttaatttgg
    11701 gatttaaaat attcccagtt ataattcttc attatttttt tgtttgtttt tgaattgaag
    11761 ttcatacatt gatttttcag aggacattct gaacaatcat cacattcata taatttgaag
    11821 tctcgcttat aaccatactt atcatgacga taggcatatc ttttaaaacc tagccgttta
    11881 ttattcggac aaatgaattc gtcattaatt tcgtcatagt tccaattttg agtattaaag
    11941 atgtcacttt tatatttttt agttttatct tttataaaca ttccatatgt tatgagtggc
    12001 gttcgattaa agtcatctat aattgcctta taatttgatt cactaccata acctgcatca
    12061 gctacaatat attcaggtaa atgaccgtag gtctcttgaa ttgaatttaa aaatggaatc
    12121 atcgttctag tatccgttgg attttgatac acattataag ataaaacaaa ttgggaattt
    12181 gtcgctattt gtaaattata ccctggctta agttgtccat ttttcatgtg atcttctttc
    12241 attctcataa atgtcgcatc atgatctgtc ttagaataac tatttctatc ctttaaaata
    12301 gatttttgaa attcgtatcg atactttcgc tcaaaataat cattgatttg ctttttgtat
    12361 tttttgattt tagttctttt gagacgtatt tgttttcttg ttttagtaca tttttcattg
    12421 ttgatatgtt ggtttaaatc ttcgatttct ttatctaagt gactaccaat caaatctatt
    12481 tcttcttttg ttaattcatt atcatgatct tttttaattt ccggtatgat tttattggtt
    12541 accaattcat ggtagagggc tttagaatcc tcattcatct ttgattcatg gttttgaata
    12601 ctctttttcc atacaaatgt atatcgattg gcatttgctt caatttttgt accatcaata
    12661 aaaatagctt tatcatctat aagattttgt tttacacact gactgtaaaa ttgaataaat
    12721 aaagattcta ataaagcatc tacttttgga tttactctaa atcgattaat tgttttataa
    12781 gaaggttttt gattttgtga tagccacatc attcggatgc tatcattaag cattttttct
    12841 attttacgac ctgagaatac agattgtgtg taggcatata gaatcacttt taacatcatt
    12901 ttaggatggt acgaagttgc accacggtga tgtctgaatt cgtcgaattc attgtcatga
    12961 attgtttcaa caatatcatt tacatgtcgt gaaatatcat ttgtggggat aagaactgaa
    13021 gtttccattg gtagagtaag ttgagtcatg ttataatttt tatacataag gcacctcgtt
    13081 aatttagttt agtgatgttt attaaattat acgaaagtgc tttatttttt taaagtatta
    13141 caatgtaaaa ttacatataa atacaaagta ttttggcgag actcttgagg gaacaggaca
    13201 agctgaagac tacaggctga agctgtcccc taagaaagcg agccaacaat acggagtatt
    13261 gtaaataaag aagccagtaa atgaatttgt taaaactcat ttactggcta tttctctagg
    13321 gtttatgtcc cagactcaat tgatttaatt tattatttta ttgcgtggaa accactatct
    13381 acatggatat tctcaccagt tacgccactt gagaaatcac tcaataagta agcagctgtt
    13441 ttacctactt cttcttgatc cacatttcgt cttaatggtg cacgttcttc aatttcttta
    13501 aggattgtgt tgcaaccacc aacaccttta gcacttaacg tacgaattgg accagcagaa
    13561 atagcattta ctcgaatgtt gtccgggcct aaatcataag ctaaatattt aacattagct
    13621 tctaaacttg ctttagctac acccatcaca ttatagtttt gaacggcaaa ttcaccacca
    13681 aggtatgttg ttgcaacaat actaccaccg tttggcatta ttttcttcgc ttcgtgcgca
    13741 acaattgtta atgaatatga actgatatct tgcgcaagta agaaaccttc acgtgatgtt
    13801 tcagagaaac gtccacgtaa gtcttcaata tttgcaaatg cgatagagtg atatacgcca
    13861 tcaatattgc ctacttcttc gccaatttta gcaaaaccat ttactacatc ttcatctttt
    13921 tgaacatcga tttgatataa ttttggctct tcttggttta attgttctaa taatttttct
    13981 aattctttgc ggctacggtc tttacgataa gtgaaaacaa gtttagcccc taattgatct
    14041 aatacctttg caacgccaaa tccgatacta cgtttattag caatacccat aattacgaag
    14101 gttttatttt caagattaat cattcgaaat aactccttaa tcatcgtttt ttatatctta
    14161 atctcactgt acaaacaatg tagactaatc taacgttatt attttaccat ttttgcttca
    14221 taattataaa gcaatattat tacctggtca tataggaaat aggctgggac aaaataaaat
    14281 gtctcagcct attttatcat tttgtcagaa gctgactgat ttgaaaatgc gcttgaatca
    14341 agcttttttc aaacctagtc atccttgccg gggtaataca acgaaataaa ttttgagaaa
    14401 atattatttc tgtcccactc ccattatttt ctctaaaaag aaattatcac ttgttaatta
    14461 taatatagtt aatatttagc aagtgaagtg tggtttatca tatgcaaaaa tcccactact
    14521 gtccaaagca aagtagggtt tttatttaat atacaaaata caaagcattt ctatattgac
    14581 aaaggataaa aatcatacta acttatgaat atatgagcat atattcataa gttagtatga
    14641 ttttcttcga gtaacaaaac attaattgaa attttatatt ttttaactct atagttataa
    14701 aaacaaaaat tcaaattata gaaaatattt ttcatcatta aaaagaggag ggattaaatg
    14761 gaaaacgatc acaatcataa tcatacacat ggcgcgaaca aaaagacttt attaattagt
    14821 tttattatta ttacaagtta catgattgta gaagggttag gtggtttctt tactaacagt
    14881 cttgcgttaa tttcagatgc tggtcatatg ttaagtgatt ctatttcttt aggtattgct
    14941 ttaattgcat ttactttagg agcgaagcaa gctaatacaa ataaaacttt tggctacaaa
    15001 aggtttgaaa tactagcagc tgtacttaat ggtattactt tgatgttaat agctatctat
    15061 attttttatg aagctattga gagatttaaa aacccccctg aggtagcttc tacaggcatg
    15121 ttaattatcg ccttggtagg cttgtttatt aatattattg tggcttggat aatgctgcgt
    15181 gggagcgatg tagaagaaaa cttaaatatg cgtggagcat atttgcatgt aataagcgac
    15241 atgcttggat ctataggtgc agttatagca gcccttctca ttatattttt tagatggggg
    15301 tgggcggatc ctttagcaag tgtgattgta gcaattttag tactacgtag cggcttttat
    15361 gtaacaaaat caagtcttca tgtattaatg gagggagcac caagcaatat aaatacaaaa
    15421 gacattatta aaactattaa aaaattcaaa gaagttaaaa atattcatga ctttcatgtt
    15481 tggtcagtaa ctagcggatt aaacgcgtta tcttgtcata ttgttgtaga agatacaatg
    15541 accattactg aaaatgagtt tttacttaaa cgtatagaac atgaactcaa tcatcaaaat
    15601 attcaacatg tcacaataca gactgaaact tctaacaata atcatagtga aaaattgttt
    15661 tgtatcgtga aagaagaaga cagtcaacat catcattaaa taaacagcca ttattaaaaa
    15721 ataatggctg tttatttaat tattccaata tatttaatat atcttttttg ttattttcaa
    15781 atcccacgta atatttaaac aacttttttt taccccaaaa atttttttta taaaaaacaa
    15841 ataagggaac aattcggttg cctgatattt ttttcatttc ttcttctaag tccaaatttt
    15901 gacttacatc tttatgacta taactaatct cttgagagtt taaatacctt tttgattctt
    15961 ggcaatcaga gcatgtaggt cttgtgtaaa gctcaagttg tatattttta tccaaatata
    16021 tctctcctaa tataagtttt agcatacatt ttatacaagt gtacctctta aaacaaacta
    16081 taaatattaa ttttttatat gaaacttttg tattgactta tacctaccag gggtataata
    16141 taggtttcaa taagacatac cccatcaggg tatacgagga ggggtgaaat tgaacactac
    16201 tactgttaaa aacaatgacg cattgctcaa tagactcaaa agattagaag gacaaatgcg
    16261 cggtttacaa tcaatgatag cagaagatag atattgtata gacgtactag tacaaataac
    16321 agcaatacaa tcagccctaa aacaagtggg ttttatagta actgaagacc atatatctaa
    16381 ttgtgtaagt gaaggtatta aaaatggcaa cggagaagaa agtatcaaag aattgatggt
    16441 tgtattaaaa caattttcaa aataggagga aagaaataat tgagtgaaaa tattaaaaaa
    16501 acctcattag gtatcacagg catgacatgt gcagcttgct cgaataaagt agaaaaaaat
    16561 ctaaataaat tagatgaagt taacgctaat gtaaatcctt ctacagagaa agctacaatt
    16621 gaatataacc ccaatgttac atcattagaa gatattgcaa atacaattca aaaaacaggt
    16681 tatggagttt taaccgaaaa agtggatctc gatgtaatgg gaatgacgtg tgcagcttgt
    16741 tcgaataaaa tcgaaaaagt tttaaatcga atctcaggtg taaataaggc tacagttaat
    16801 ttaaccacag aaagtgctac tgtagaatac aaccctgata tgacgtctgt agatgaattt
    16861 caacaacgta ttaaaaacct agggtatgag gcacaaccta aaaaagaagc atcagaaaaa
    16921 agttcccaaa aagaaaaaca attaaaacga cagttaatta aattagttgt ttcagctgtt
    16981 ttagcagctc cattgttaat gacaatgttc gttcatttat ttggtattca aataccacat
    17041 atatttatga acccgtggtt ccaatttgta ttagcaacgc ctgttcaatt tgttattggt
    17101 tggcaatttt atgtaggcgc ttataaaaac cttcgtaatg ggtcagcaaa tatggatgtt
    17161 cttgtcgctt taggtacaag cgcagccttc ttttatagta tttatgaatc gattaagtgg
    17221 ttaattaata caaattatga gccacaccta tattttgaaa caagtgctgt attaattact
    17281 ttaattcttt tcggaaagta tttagaagca cgtgctaaaa cacaaacaac aaatgcgtta
    17341 agtaaattgt tgaatttaca agctaaagaa gcacgtatat tacgcaacgg tgaagagact
    17401 atggttcctt taagtgaagt aaaagaagga gactatttag ttatcaaacc aggagaaaaa
    17461 ataccagtag atggcaaaat aattaaaggt atgacttcaa ttgacgagtc aatgttgaca
    17521 ggtgaatcta ttcctgttga aaaaatgcaa aatgataatg ttataggatc aacaatgaat
    17581 aaaaatggag caattactgt tgaagcaaca aaagttggta aagatacagc tcttgcctcc
    17641 attgttaaag ttgtcgaaga agcgcaaggt tctaaagcgc caatacaaag actagcagat
    17701 attatttctg gatattttgt acctatcgtt gtaggtatcg cgattttcac atttattata
    17761 tggatttcat tagttcagcc gggacaattt gaaccagcct tagttgctgc aatagcagta
    17821 ttagttattg cttgtccttg tgcgttaggc ttagctacgc ctacttctat aatggtgggt
    17881 accggaaaag ctgctgaaaa tggcattcta tttaaaggtg gagaacacat tgaaggtaca
    17941 catgctatta atacagttgt tttagataaa actggcacta taacaaatgg cacacctgaa
    18001 gtcactgatt ttagtggaga tgatcaaaca ttacaattat tagctagtgc agaaaaaggt
    18061 tctgaacacc cactagctga agctatcgta agttatgcta aagaaaaatc attagaattt
    18121 ttagaagtag atcattttga agctatacca gggcgcggta taaatgcaac aattgatggt
    18181 aaagaacttt ttgttggaaa tcgaaaacta atgagtgaaa aaggaatccg aactaatgaa
    18241 gctgaaacaa atctcgctca atttgaaaaa gaaggaaaaa ctgcaatgct tataagcgta
    18301 gataacgaat tgagaggggt tgtcgctgta gccgatacag ttaaagatac tgcccaacaa
    18361 gctattcaaa aacttcatga attaggtatt gaagttgcta tgttaactgg tgataacaaa
    18421 cgtaccgcac aagcaatagc aaaacaagtt ggtatagaca cgattattgc agaggtttta
    18481 ccagaagaaa aagcttctaa agtagcagaa attcaatctg aaggtaaaaa agtagctatg
    18541 gttggagatg gtgtcaatga tgctccagca ctagttaaag cagatattgg tattgccatt
    18601 ggtacaggta cagaagttgc aatcgaagct gctgatataa ctattttagg aggagacctt
    18661 ttattaattc caaaagcaat aaaagcaagt aaatctacaa ttcgtaatat tcgccaaaat
    18721 ctattttggg cgtttggtta caatgttgca ggtatcccta tagcagcaat tggtctgcta
    18781 gcaccttggg ttgcgggagc agcaatggct ttaagttctg taagtgttgt cacaaacgct
    18841 ttacgtctaa aacgtatgaa attataagaa tcttatattt cttgaaagga ggtgacaaca
    18901 ttgactaacg aagttattaa tgtagaaggt atgagctgtg accattgcaa gcattcaatt
    18961 gaaaaagcat taaatggatt agatggtgta acatcttcag aagtaagctt ggcgaatggg
    19021 aatgtggaag ttgaatttga tgaaaatcaa gtagctttca acgactttaa agaagctatt
    19081 gaagatcaag gttacgatgt aattaaataa tttaaatagt tgggcatatc gtttaatgat
    19141 atgcccttat taaaaattaa ggaggataaa aatatgaatc ataatcatga atatcattca
    19201 aacaaacccg aaattaaagc aaatgttgta tatagagatg gtaatataga aattacgtta
    19261 gaagatgaat ttaataatgc cccattatta gatactatgc atgaaaaaga aatgcatttc
    19321 gttttagtat ctaatgacat ggagaaatat taccacctac accctcaaaa aaagcatgaa
    19381 ggtttattta taattaacca acaattagag ccaggaactt accaggcttt tgttgatgtt
    19441 acaccaaaaa accatgtgta ttccgttcat cctattgaac tgcaaattgg agataaaata
    19501 acctatacaa catctttaaa ttctgataaa aattgggtaa aagttaacaa aggagttcat
    19561 gtaactttaa attctataag tgctaaagaa gatgaacatg tccctttaac tttcaataca
    19621 gaattaactc cccaacctta tttaggagct ttaggacatg tgattatatt tgatgagcaa
    19681 ttaactgatt atattcatgt tcacccagaa tcacctgatt ctacaacctt ttatgctcat
    19741 tttcctaaaa aagggatgta taaaatttgg gcagaattta aatttaatga tgaagtgcat
    19801 agatttactt ataatattaa agttgcataa atctattagc aaaagcttaa aaatcagtaa
    19861 attgtaaaga gttatttaga taatacaaaa agctttataa aaaatcgaaa atttaagata
    19921 gaaagttgat gaagaaagta tcaaaaaatt gtagtggctg tttatattgc aacattcact
    19981 gaatttttat agttaataac ctattattta aggagtaatt tattgattaa gtttgaatat
    20041 tttgaggaga aagattttga tttattaata aactggataa actctcctga acttttagtc
    20101 aaatgggcag gtacagattt taattatccc ctagatgaag aacaattaaa ggaatatatt
    20161 aaagacacaa ataaagaaaa ttctagtaaa ataatttata aagttatcat tgaagaaaat
    20221 aattcaaaaa aaattatagg tcatattgct ttaaataata tagattttaa aaattgttcc
    20281 gccacgttag gtaaagtttt agtaggtgat ccgcaaatgc gtggccaagg attaggccct
    20341 aaaataataa agaaattatt gaaaaaggct tttgaagatt tgggactaca cagaattgaa
    20401 ttaggtgttt ttgcctttaa taaatcagct attaaaagtt acaaaaagat tggatttata
    20461 aaagaaggag aaaaaagaga ctttagaaaa ttaaatggag aatattataa tttatggcaa
    20521 atgagtatgt tagaaagcga atggtcttga ataattttaa acaaaaatag ccctcttatt
    20581 aaaataagag gactattttt gtttatttag agcgtactta taaaatgcag cacttcattt
    20641 aatttatatt tatgtatctc aacatgtatt taaataattt atttttttat gatacattaa
    20701 gtttggattt aaaatatatc taaataatta aaaaggagat aattgtatgg atgttttaac
    20761 agtagaacat ttaacaaaaa agataggtaa taagactatt ctcaaagata tttctttaaa
    20821 tttaaaacga ggacagattg tcggtcttgt tggagcaaat ggggcaggaa aaacatcttt
    20881 gatgaaagtt atattaggct actcgattta tcaagaaggt aactttgaag ttattgaaaa
    20941 taagcataaa aaaagtaacg ttggtgcatt gatcgaaaat ccaggagtat atccctttat
    21001 gtcaggctat gacaatctta aactactaaa tgaaactaaa aatactcaag atattgatac
    21061 aattgtctct caacttaaaa tggatgagta tatacataat aaagccaaaa catattcctt
    21121 gggtatgaaa caaaaattag gtattgcaat agctttctta aatcaacccc aattaattat
    21181 tttagatgaa cctatgaatg ggttagatcc tagggctgta agagatgtta gagaactcat
    21241 tgtaaaaaaa gcggaagagg gcgttacctt tttaatttct agccatatat taagtgagtt
    21301 agtaaaaatc accaattcta tccttatcat taacaaaggt aaaattgtta ctgaaactac
    21361 cgaagaagaa ttaaaccaat ataaagataa cgatttagaa aatgtattat taagtatcat
    21421 tgataaggag gatcaatcgt aaaatgggca ctttaattaa gcaagaatgt tttaaattgt
    21481 ttaaaaagaa atcgacgttt attataccaa ttatcattat gttattaatg gttgttcaag
    21541 ctataatatc taaaaactat gatgatgttt tttctccaca atcatctatt gaatcagcat
    21601 ttagtggttt ttcatggttt atctttttat taattattca agccagcacc attatttcaa
    21661 tggagtttta tcatggtaca attaaaaatc ttctctatcg aaaatatacg agaacaagca
    21721 ttattattag taaaattatt acattaatac ttttttcact actgtatttt attgttagta
    21781 ttgttgtagg aattattcta tgggctattt tcttcaacga tatcaatctc cttgaaagta
    21841 agggtgatgc gttatcgtta ttaagtaaaa tgttattaac tggactaggt acatatgttg
    21901 gaacatggtt agtcttaagt atcaccttat taatttcatg tgcaatgaaa agtcccggtg
    21961 tctctattgc tgtcggtatt gtattgtatt ttgccacttc aattttgtca gggatattaa
    22021 caattgttgt agataaatgg gaatggttaa aatggaaccc tattagtatg atgaatatta
    22081 tggttcaaat tgttgataaa aacatgaaaa aattcacaaa attagaactg catgaattat
    22141 ttattggtaa tattgtttat attattattt tcttaatcat cgtagtattt gtctttaaaa
    22201 agaaaaatgt ctaatctaac tcaacacact ttataatttt gcattcctct actaaccagt
    22261 gttataatct acttaactcc cgtaagggcg cacttatacg tttgttccaa acgctagtgt
    22321 agatccgtca tcgacctgcg tcgattttta attttaaatt caaagaaacg gcttgagata
    22381 ttccgagcag ttataaaaat taatttgtgt cgaatatcgc tactacattc ttgaaaaagt
    22441 gatgtagatt tttagcccat aacttttttt atttacatcg acgatacggc gtcgaaggaa
    22501 aaataaacag accgtacgaa agaaaaagcc aatccacttt gtctgggttg gcttttattt
    22561 ttatatccaa agacgcactt acacacctaa aaaagtgtcg tactaaaacc aaaactcata
    22621 tgtgataagc taatatcctt attttgcatt ttaaggggta ttttatatgt ttttttacat
    22681 aagctcttaa aacacaaatg agagccaaat aaaggttctg tatggactat gattgcctca
    22741 ttcactctgt ttacataacc aatgattatc agaagttcca tcactataaa aggtgtatca
    22801 aagatttata acccccttga tacacctttt acattcattt ttaattaccg aagaatcgac
    22861 tccaaaatcc ctttttaggt ggttctacct ccctattatc atcaggatca ctcttcgttt
    22921 cttcaacgaa cttatcctct tttgttaatt caccttcatt tgtactgtcg ttctttttct
    22981 cttcggctat atccttgtaa tttacttctg ttggttgacg ctttgtttgt tgttggttga
    23041 tattttgcga ttcttcagta aaagttgctt cttgcgaatt aatattttgt ctattattcg
    23101 tcgctgtatc aaaagaataa ttaagctgtc tttcttcttc taattggttt tctagttttt
    23161 gaattttttt attgctttct aaagctaata tttgttgatt ctccaacaat ttatttaatg
    23221 tattaacatt gctattttgt tgatctaatt gcttagttaa attctcaata tatttttcat
    23281 catttttagc tctagtttca aagatttcta tttgcttttc taattcattt acttttgttt
    23341 ttaatgtctc agaactattt gaattattat atatattctt ttctgctttt gcagtatttt
    23401 caccaaacaa ttcttttttt actgattctt tattttggat tgtactctct ttcttagtaa
    23461 ttttttctat aattttcaaa taatccttat catcaatata attaatccca ttttcttttt
    23521 caaaagctat atttaaactt ttagcattat taacaatagt ttgtttagtt acacctaatt
    23581 catcagcaac cattttaata gttctcataa cattcaccct taggtaccta atttagtacc
    23641 taaattttac cacctaatga agtttatttc atcatttacc gcctaaattt actacctatt
    23701 tactacctat gcacctaatt agctccctat aatatgtttt cgaagcttaa ttaggtacta
    23761 aaacaatgaa ctacacattt tgccatggca atgtgctttt aactacattt aaaactcttt
    23821 atatactttc ttaaaagtgt taatattgct ttataaatat taaaagagtc aatgctattg
    23881 gcgtagcatt gactctcggt aataaaacga ttcgcactcg tttgcttata tattttttga
    23941 tacttgtatt atatctatct aatcatctaa gtgcaagcac aaaacatata acttacgtaa
    24001 aaattgtttt attacctcaa tcctaaaaat ggaaatgagg tttttatt
//
