LOCUS       CP052567                8619 bp    DNA     circular BCT 04-MAY-2020
DEFINITION  Klebsiella pneumoniae strain A16KP0127 plasmid pA16KP0127-2,
            complete sequence.
ACCESSION   CP052567
VERSION     CP052567.1
DBLINK      BioProject: PRJNA625837
            BioSample: SAMN14609860
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 8619)
  AUTHORS   Yoon,E.-J., Gwon,B., Liu,C., Kim,D., Won,D., Park,S.G., Choi,J.R.
            and Jeong,S.H.
  TITLE     Built-in CTX-M extended-spectrum beta-lactamase gene in Klebsiella
            pneumoniae ensuring stable propagation of the multidrug-resistant
            pathogen in clinical settings
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8619)
  AUTHORS   Yoon,E.-J., Gwon,B., Liu,C., Kim,D., Won,D., Park,S.G., Choi,J.R.
            and Jeong,S.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-APR-2020) Research Institute of Bacterial Resistance,
            Yonsei University College of Medicine, 211, Eonjuro, Gangnam-Gu,
            Seoul 06273, Korea, Republic of
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: Oxford Nanopore and Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/27/2020 22:14:53
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 5,439
            CDSs (total)                      :: 5,315
            Genes (coding)                    :: 5,207
            CDSs (with protein)               :: 5,207
            Genes (RNA)                       :: 124
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 87
            ncRNAs                            :: 12
            Pseudo Genes (total)              :: 108
            CDSs (without protein)            :: 108
            Pseudo Genes (ambiguous residues) :: 0 of 108
            Pseudo Genes (frameshifted)       :: 45 of 108
            Pseudo Genes (incomplete)         :: 58 of 108
            Pseudo Genes (internal stop)      :: 21 of 108
            Pseudo Genes (multiple problems)  :: 16 of 108
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..8619
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="A16KP0127"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="pA16KP0127-2"
                     /geo_loc_name="South Korea: Seoul"
                     /lat_lon="37.57 N 126.98 E"
                     /collection_date="2016"
                     /collected_by="Kor-GLASS"
     gene            join(8367..8619,1..50)
                     /locus_tag="HJW72_27125"
     CDS             join(8367..8619,1..50)
                     /locus_tag="HJW72_27125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008451932.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mobilization protein"
                     /protein_id="QJM50673.1"
                     /translation="MAKSRAEKLEELRQKEAQIKAQIQQLKQREQTEERKKDTRRKILI
                     GGAVLAKIKRGEWNYHQLVSLLDNELKNDRDRALFDEMGLKAVDARKESFNPGNK"
                     /name="mobilization protein"
     gene            1205..2581
                     /locus_tag="HJW72_27130"
     CDS             1205..2581
                     /locus_tag="HJW72_27130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002804305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type IV secretory system conjugative DNA transfer
                     family protein"
                     /protein_id="QJM50674.1"
                     /translation="MRENNHLLPTEKQAGFTLARELSPPPGVDGKFCFTGHVVTVAPTG
                     SGKGIGAVIPNLLTYQGSALVFDPKGENAEVTGRRRREMGQSVHVIDPFGITSGIKESV
                     NILDRLDVTSPDCVAESAVLAESLVVSEKGGDSNHFDESARTLLQGLMLHVSGLPDESR
                     RNLAELRRLITSDEENLLALLADMAASEDVAFGIPARAANTLMGMADRERGSVLSTARK
                     NTAFLDDPRIAAALSHSDFNLSAIKAEPMTVYLVLPANRIAANTRFIRLFIGSVISAVT
                     ESKAKPAHNVAFILDEFNVLGYMKSIEDAVSLLRGYGLSFWVFLQDLSQLKSAYPKWQT
                     FLANSAKTFYGTDDYDTAKYVSDTLGKSTVEFETQNSGRNSGSGVSGGGGSMNRGRSSG
                     SSQQFAGRELLTPDEVMRLGPTRPIVILKGEYPYQLTRINYLTDPEYAGMADPNPYYSA
                     "
                     /name="type IV secretory system conjugative DNA transfer
                     family protein"
     gene            complement(2834..3193)
                     /locus_tag="HJW72_27135"
     CDS             complement(2834..3193)
                     /locus_tag="HJW72_27135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019454714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="entry exclusion protein 1"
                     /protein_id="QJM50668.1"
                     /translation="MAWHSVSQAQNMTGKSRRTLYRDMASGRLSWRTNASGHRELETSE
                     LIRVYGQIKNDGTAERHTVAQPDGTVPSSVMMDELRALRQEVADLKSMLLRLEHKPEKP
                     PIAAPWWRFWQKKST"
                     /name="entry exclusion protein 1"
     gene            3553..3693
                     /locus_tag="HJW72_27140"
     CDS             3553..3693
                     /locus_tag="HJW72_27140"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="QJM50669.1"
                     /translation="MQEPPVQPDCCAFPGNYRLESNPGRHDKAPLAAAIGNWEFAENLF
                     S"
                     /name="replication initiation protein"
     gene            complement(4082..4576)
                     /locus_tag="HJW72_27145"
     CDS             complement(4082..4576)
                     /locus_tag="HJW72_27145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000929317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QJM50670.1"
                     /translation="MAGTVWNDVNTGREVFSMTHLHPQLHKVEVSGVQAELEISFGFHV
                     FTDQKQVGKVMNFRGETRHFCQERYEGSKTIVQRILSAIENGEYITAFISKGQGQRYYH
                     LNHHDDFILMEIRKPEGKDNFLRIHVVTAYTLDEWGTVNKGRNLRFRYVLEQRLQGKKI
                     V"
                     /name="hypothetical protein"
     gene            complement(4580..5011)
                     /locus_tag="HJW72_27150"
     CDS             complement(4580..5011)
                     /locus_tag="HJW72_27150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014640499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QJM50675.1"
                     /translation="METWDRNDRPRNDGFITVPRYLPLLGVLMDELSKGSPLSSTYLAL
                     WFRGSDEGLIEIRDKTVLALESGFASARGVTTWTGRMRKLKELGFISCREGSSGEFHNV
                     LIVHPLVAVKKLLDEGKITKGKTYNTFAERVIEVKSSWE"
                     /name="hypothetical protein"
     gene            complement(5822..6241)
                     /locus_tag="HJW72_27155"
     CDS             complement(5822..6241)
                     /locus_tag="HJW72_27155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001618753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HigA family addiction module antidote protein"
                     /protein_id="QJM50671.1"
                     /translation="MSEEQRRRGFMKAEASLRLEGIDPSGIPRYESIKARVISGEITYE
                     QGRAEILAFHTGKCAEPTTAGEMLAEEFLKPLNMSQGELAQATGIPEHHIDDIISNRRR
                     LSAQESYKLAEQFQTDKDFWLNLQALHDAWLTHQR"
                     /name="HigA family addiction module antidote protein"
     gene            complement(6384..8207)
                     /locus_tag="HJW72_27160"
     CDS             complement(6384..8207)
                     /locus_tag="HJW72_27160"
                     /inference="COORDINATES: protein motif:HMM:NF015354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobA/MobL family protein"
                     /protein_id="QJM50672.1"
                     /translation="MAIFHLSVKTISRSAGRSATAAIAYRTGSRIVDERTGITHDYTRK
                     SGVEHSEIFLPQNSPGWASNRETLWNAVEQKENRRNSTVAREFELAFPAELDGKQRLDL
                     LREFCSSLVERHGMAVDAAIHAPGKEGDQRNYHAHVLCSTRRLSEEGFKDKTRELDDFK
                     SGEVNYWRSAWSEMTNRHLEKAGRSERIDHRSLEAQRESAISQGDSAKAAELDRVPTIH
                     IGYAAAQMEKRGIETERGNEHRQIILRNAEIQPLSRAIQLIENWRATHDNNSRAGHGSI
                     APVPARDTGRDRRGVRTAQSNTGRAGAVPPPSARGRLRNLSELDMVRFGERSEMLLPGN
                     VSRDVEHQRTDRNQPLRRENTVTSKPKRPEIIRLEWQRLRRDKLTFVHDKAGRIAARGA
                     AQVERQRQKISSHERQRPEQPSGLIGMFKRSAYEQAASTWQTIKNGLDRRLVQLKNRLG
                     FVRGYMRKSGAYEMSTPGERLADQLAAKENPILAGQIKSLNAQKNAEDMAAYRTRVQSR
                     KQEKADMKLETIEELKQRGDARRDKADKAERAELEKASHQASLQNETIGEETKELESGE
                     KEKLSKRDQVLEKFKAKFERDKQNERGGRGR"
                     /name="MobA/MobL family protein"
     Typing          3295..3662
                     /name="rep_cluster_2370"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="90.296"
                     /coverage="85.0"
                     /evalue="3.95e-133"
ORIGIN
        1 taaaggcggt tgacgccaga aaagaatctt ttaaccccgg taataagtga cgccaattac
       61 ttattctcgg atgataaatc agatcaggag atttagcgtg aaaaaaaata tacaggccgg
      121 gattttcttc gtcacaatgc tatttccagt atggcatgca gcggccgaaa cattcacccg
      181 ctgccatcca aatgagactg tctgggcaat gatccaggat gagcagctaa aaaacatcgc
      241 cagactacag gaaacaaagc ggtgtcaggc cgttaatgac acttatgacc agtggcgcca
      301 aaatttccag gcgatgggag atgcagaaaa cgccatccgc agcgcccgcg ataatcagaa
      361 ctggaacgcc gtaaaatcca cgttcgataa cattgctccc cagattaata gcctgcatgc
      421 actggcagaa aaaaattcat cgttactggg cgcgggtaac atcctggcgc ttttcggcgg
      481 cgatctgaat tacctgtacc agaatgcagg gctcgttgcc ccggccagcg ctgatggact
      541 gacagataac gtcagtcaaa tgctgactga accggataaa caggtcaaag ctgcaggtat
      601 cgcgcaacag ctggtttatc agactcgggt tagggcacag agttttatcc aaggcgtggc
      661 acagaacgcc ggtaacgaag cccagaaaga gtatcgtgag caaacaaata agattgtcga
      721 ggataaagcc cataatttta aaggtgacag cgtggaagga tatttcggcg gctttcttgc
      781 ccggataagc caggtatatg ctccagttct gctgttcctt atcatcgttg gtattattgg
      841 tgcacttacc gcacggcggg taaggctgga tgctttcacg gcatcagtga aagcagttat
      901 ggccgcagtg gtacctgcag tagcactggc gctgatgctg atattcatgc ctttcctacc
      961 atcatgggta ttgtacacgg cagcgctggc cggaacattc gccatttatt cccgcagtaa
     1021 acaaattctt ggagggctgg cctctcgctg tgggcgtttc cccgcactgg cctccgggct
     1081 tcgctggatg ggcggttttg tgtctggcat cgatgctgac agaaagcagg aaacgggcgc
     1141 ggcatccgtc aacccagcat cacatcacac tcacggctca tcacgctggg gaaccgctgc
     1201 agaaatgcgg gaaaataacc acctgttacc aacggaaaag caagccggat tcaccctggc
     1261 acgagaactg tccccaccgc ccggagtgga tggaaaattc tgtttcaccg ggcacgttgt
     1321 gactgttgcc cctacgggca gcggaaaagg gattggcgca gtaattccca atcttctgac
     1381 ttatcaaggt tcagcgcttg tttttgatcc aaaaggggaa aacgccgagg tgacaggtcg
     1441 ccgccgtcgt gaaatgggtc agagcgtcca cgtaattgac ccattcggta taaccagcgg
     1501 cataaaagaa tcagtgaaca ttctggatcg tctcgatgtg accagcccag attgcgtcgc
     1561 tgaatctgca gttctggccg aaagccttgt ggtatcagag aaaggtggtg acagtaatca
     1621 ttttgatgaa tcagcccgga ccctgttaca gggcctgatg ctgcatgttt ccggattacc
     1681 ggatgagtcc cgacgtaatc tcgcggaact acgtcgactg atcaccagtg atgaagaaaa
     1741 cctgttagcc ctgctggccg atatggccgc aagtgaagac gttgctttcg gtatccccgc
     1801 ccgagcggcc aacacgctca tggggatggc agaccgggaa cgaggctcag tattgtctac
     1861 cgcccgtaaa aacacagcat ttctggacga cccgcgtata gcagctgcgc tgtcacactc
     1921 agacttcaac ctgtcagcca tcaaagctga accgatgaca gtttatctcg tgctaccagc
     1981 taatcgcatt gcagcaaata cccgatttat aaggctgttt atcggttctg tgatctccgc
     2041 tgtaacagaa tcgaaggcga agccagctca taatgtcgca ttcatcctcg atgagttcaa
     2101 cgtgctgggg tatatgaaat caatcgagga tgccgtaagc ctgttacgcg gctacgggct
     2161 gtctttctgg gtattcctgc aggatctgtc acagctgaaa agtgcttacc ctaaatggca
     2221 gacgtttctg gccaactcag cgaagacgtt ctacggcaca gacgactatg acactgcaaa
     2281 atacgtcagc gataccctgg gtaaatcgac ggttgaattt gaaacccaga attcaggccg
     2341 caactctggc agcggtgttt ccgggggtgg cggctccatg aatcggggtc gttcgtctgg
     2401 atcaagtcag cagtttgctg ggagggaatt actgacacct gacgaagtca tgaggcttgg
     2461 accaacccga ccaattgtga ttctgaaagg ggaataccct tatcagctca cccgtattaa
     2521 ctatctgaca gacccagaat acgcgggtat ggcagatcct aacccctact acagcgcatg
     2581 atatttggaa tcgttgtcag cgtactgtta gctctgatgt ttggccgggt cttgctcccg
     2641 gccttaaccg ccgtcgcctt tgtgataggc ataccgatat acttctcttt ccgatttatc
     2701 tgtgccttta tctgggctct ggtgacgcaa aacagaagac gtagtgctat gacaatagcg
     2761 acacaaaaga caacaaagcc tgaaacacta ccggataacg taatcagctt tagccgcgaa
     2821 aaagagaaaa gagttaagta gattttttct gccagaaacg ccaccacgga gccgctattg
     2881 gcggcttttc cggtttatgc tcaagcctta acagcataga tttaaggtca gcaacttcct
     2941 gccgtaaagc acgcaattca tccatcatga cactactggg cactgtgcca tcaggttgtg
     3001 ccacggtgtg ccgttcagct gtgccatcgt ttttaatctg gccataaaca cggatcagct
     3061 ctgaggtctc aagttcgcga tgaccgctag cattagttcg ccatgacaag cggccggacg
     3121 ccatatcccg ataaagggtt ctgcgacttt tccctgtcat gttttgtgct tgtgacacac
     3181 tgtgccatgc cataacaccc ccccttgatt aagtgacaca ctctacgggc tgcactctag
     3241 caggctaacg gcatccgggc acgcggcaag aaggaggaaa aaagccgaag acccgttttt
     3301 ccataggctc cgcccccctg gcgagcatca caaaaacaga cgctcaagcc aaaggcggcg
     3361 aaacctgaca ggactataaa gatcatcacc gtttccggtg aatcgctccc tcttgcgctc
     3421 tcctgttccg accgtgtcgc tttaccggat acctgaccgc ctttttccct tacgggacat
     3481 gtggcgcttt ctcatagctc acactgtagg tatctcagct cgatgtaggt cgttcgctcc
     3541 aagctgggct gtatgcaaga accccccgtt cagcccgact gctgcgcctt tcccggtaac
     3601 tatcgtcttg agtccaaccc gggaagacac gacaaagcgc cactggcagc agccattggt
     3661 aactgggagt tcgcagagaa tttgtttagc taaacacgcg gttgctcttg aagtgtgcgc
     3721 caaagtacgg ctacactgga aggacagatt tggttgctgt gctctgcgaa agccagttac
     3781 cacggttcag aaacttgccg gtttactgaa ccttcgaaaa accaccttgc cgggtggttt
     3841 tttcgtttac aggacaagag actacgacga taaacaaagg atctcaagaa gatcatgaca
     3901 aacccgtgaa gttgacaagt ggcatgggta agtggacaat atacctgtca gcacaaaccg
     3961 gaaccttgaa agaggggtgc tgatgccggg ggcaaaccct cctagccagt gagcgggata
     4021 acgaaaggcc agaccgaaat ttttgcagta aaacaaaggc gccttgggcg ctttttgttt
     4081 tttatactat tttcttcccc tgtaacctct gctccaaaac atacctgaac ctcaaattcc
     4141 gtcctttgtt gaccgtcccc cattcatcaa gcgtatatgc tgtaacaaca tgtatgcgaa
     4201 gaaaattatc tttaccttca ggctttctta tctccattag aatgaagtca tcatgatggt
     4261 taaggtggta atatcgctgc ccttgcccct tggaaataaa ggccgttatg tactctccgt
     4321 tttctatcgc tgacagtatc cgctgtacga tagtcttact tccttcgtat ctttcctggc
     4381 agaaatgccg agtttcacct ctgaaattca ttacctttcc gacttgcttt tggtcagtaa
     4441 atacatgaaa cccgaagcta atctcaagct cagcctgcac cccagaaacc tcaaccttat
     4501 gcagctgagg gtgcaggtgt gtcatcgaga aaacttcacg ccctgtatta acatcattcc
     4561 ataccgtacc tgccatttct tactcccatg aggacttcac ctcgattacc cgttcagcaa
     4621 aagtgttata ggttttccct ttcgttattt tcccttcatc cagtagtttc tttaccgcaa
     4681 ccagcggatg aacaatcaac acgttgtgga actcaccgga gctaccttcc cggcatgata
     4741 taaatcccag ctcttttaat ttccgcattc tccccgtcca tgttgttacc ccccttgcac
     4801 tggcaaagcc tgattctaaa gccagcacag tcttatccct tatctctatc aggccttcgt
     4861 ctgaacccct gaaccacagc gctaggtagg tacttgaaag tgggcttccc tttgataact
     4921 catccataag aacacctagt aatggaagat aacgaggtac tgttatgaag ccatcgtttc
     4981 gaggtcggtc attacgatcc catgtttcaa tttcctcccc ttcccataat gtatttatca
     5041 gttcgattct tctttcagac tggttacgtt tccctgctct ttgtgccctg actgacatac
     5101 tcgcctcctg ttaatgcgcg agagataatt taccaaaaaa cccttataaa tcaataactt
     5161 ttataaattc ccttgaacga tcacttccgg tttttatttt ttttaatcat aaaaaatgca
     5221 atatttatta cacaaaaggc ggttacaagt aataaatatt acaaacacaa aatgcattta
     5281 tatgatttaa aaagagtttt tatttaattg cggtgctcca tgtgctcatc gtgctccatg
     5341 tgcttctggt gctcccttgt gctccatggg gttgtagggg gcaaggaggg ggggagaaat
     5401 cgaaaaataa attaagagtc accatgctgg ttactcgcat ttaccataac atccgttagc
     5461 agaaccgcct cagaggccct cagcgcgttt ttatgccata agcctcaaaa gaacatgatt
     5521 acccaattaa aaggccgcaa aatcgcactg gtgagttttt ggtggtatga attgatatgc
     5581 acacaaatga atggcaatca atttagccgg gaaaagaagg tcaaagggtc aaaaccgtcc
     5641 atttcattgg ggttaataca tgatttttgg atgtccggat ttcggaacca ttatgacact
     5701 tgaggggcag gaaaaaacaa agccccgcct ggtaaggacg gggctgtttt taatgctctg
     5761 acctgcatgg aacatcctac attagactga aatattatat atctaatagc gcccctggct
     5821 gctatctctg gtgcgtcagc catgcgtcat gcaaagcctg caggttgagc cagaaatctt
     5881 tatcggtctg gaactgttca gccagcttgt aagactcctg agcactgagg cgacggcggt
     5941 tactgataat atcatcgata tgatgctcag gaattcctgt agcctgcgcc agttccccct
     6001 gagacatgtt cagaggtttt aaaaattcct ctgcgagcat ttcccccgca gttgtcggct
     6061 ccgcacactt cccggtatgg aaagccagaa tttcagctcg tccctgctca taggttatct
     6121 cacccgaaat aactctcgct ttaatcgact cgtagcgggg gattccgctg ggatctatac
     6181 cttccagtct caggcttgcc tcagccttca tgaagccacg cctgcgctgt tcttcactca
     6241 tatctacctc atatgtcaat atcaggcgta cctcatatgt catgaaatac tgttaaccag
     6301 tacaatgctt tcagcccgaa aagacgcctg atcagtctgg ccgggtcagg tatgcagcat
     6361 ggttggcgct gtgttgcata ccgctaacgc ccacggccac cacgttcatt ctgcttatcc
     6421 ctctcgaatt ttgctttaaa cttctccaga acctgatcac gcttgctgag tttctctttc
     6481 tctccggact ccagttcttt tgtctcttcg ccgatcgttt cattctgcag tgaagcctga
     6541 tgagacgctt tttccagctc tgcacgttcg gctttgtcgg ctttatctct ccgggcatca
     6601 ccacgctgtt tgagttcttc gatagtttcc agcttcatat cagctttctc ctgtttgcgg
     6661 gactgtacgc gggtacggta tgcggccata tcttccgcgt tcttctgagc attgagcgat
     6721 tttatctgcc cagccaggat cggattttct ttcgcggcca gctggtcggc cagccgttct
     6781 cccggcgtag acatttcgta agcgccagac ttgcgcatgt agcctctgac aaagccaagc
     6841 cgatttttca gttgcaccag acgacgatcg agaccatttt tgatggtctg ccaggtactg
     6901 gcggcctgtt cataggcgct gcgcttaaac attcctatca ggccgctggg ctgttctggt
     6961 ctttgtcgct catgtgagga tattttttgt ctctggcgtt caacctgtgc cgccccacgg
     7021 gcggcaatcc gtccggcctt atcgtgaacg aaagtcagct tatcccggcg taaacgttgc
     7081 cattcaagcc ggataatttc cggtcgcttt ggcttgctgg ttacagtgtt ttcccgtcgc
     7141 agaggctgat ttctgtcggt tctctggtgc tccacgtcac gagatacatt gcccggcaat
     7201 aacatctcac ttcgttctcc gaagcgaacc atatcgagtt cggacaggtt gcgcaggcga
     7261 ccccttgcgc tgggcggcgg gacggctcca gcgcggccag tgttggactg agcggtgcgg
     7321 actcctctcc tatctcgccc tgtgtctcgt gcagggactg gagcaatgct tccatgtcct
     7381 gctctgctgt tgttgtcatg ggttgccctc cagttttcaa tcagctgaat tgcccgtgaa
     7441 agcggctgga tttcagcatt acgcaatatt atctggcgat gttcattgcc tcgttcggtc
     7501 tctatgccgc gcttttccat ctgcgcagct gcgtaaccga tatgaatagt cggaacccga
     7561 tccagctccg ctgccttggc ggaatccccc tgagaaatag ctgattcccg ttgcgcctca
     7621 agtgaacgat ggtcaatacg ctctgaacgg ccagcttttt ccagatgacg gttcgtcatt
     7681 tctgaccatg cagaacgcca gtagttgact tcgccgctct taaaatcatc aagttcacgg
     7741 gtcttatcct tgaaaccttc ctccgacagt cggcgggtac tgcataaaac atgagcatga
     7801 taattacgct ggtcaccctc tttacccgga gcatggatag cggcatccac tgccattccg
     7861 tgacgctcaa ccagtgaaga acaaaactca cgaagcagat cgagacgctg ttttccgtca
     7921 agctcggcag gaaatgcgag ttcaaattct ctggcaacag ttgaattacg acggttttct
     7981 ttctgttcaa ctgcattcca gagagtctcc cgattactcg cccaacctgg tgagttttga
     8041 gggagaaaaa tctctgaatg ctcgacgcct gatttacggg tgtagtcgtg ggtaatccca
     8101 gttcgctcat caacaattct tgaacctgta cgataagcaa ttgccgcagt ggccgaacgg
     8161 ccagcactac ggcttattgt cttaacgcta agatgaaaaa ttgccaattt agtattcctg
     8221 tttttccttt gaccttgggt gcagggtttt aaccctgccg cacgcaaact cgaagagttt
     8281 gcataagtgc gccctttgct ttcgcttcgg gttgaaatat atcagcaatg gagttatcgt
     8341 tcaaatttga atcaaggagg tgaataatgg caaaatcaag agcggaaaag ttggaagagt
     8401 tgcgtcagaa agaagctcag ataaaggcgc aaattcagca attaaagcaa agagagcaga
     8461 cagaagaacg caagaaggat acccgacgaa aaatcctaat cggtggtgcc gtactcgcaa
     8521 aaataaagcg tggggaatgg aattatcatc agctggtgag tcttctggac aatgagctga
     8581 aaaatgacag agaccgggca ctgtttgatg aaatgggtt
//
