LOCUS       CP052548                9294 bp    DNA     circular BCT 04-MAY-2020
DEFINITION  Klebsiella pneumoniae strain B16KP0089 plasmid pB16KP0089-2,
            complete sequence.
ACCESSION   CP052548
VERSION     CP052548.1
DBLINK      BioProject: PRJNA625837
            BioSample: SAMN14609867
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 9294)
  AUTHORS   Yoon,E.-J., Gwon,B., Liu,C., Kim,D., Won,D., Park,S.G., Choi,J.R.
            and Jeong,S.H.
  TITLE     Built-in CTX-M extended-spectrum beta-lactamase gene in Klebsiella
            pneumoniae ensuring stable propagation of the multidrug-resistant
            pathogen in clinical settings
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9294)
  AUTHORS   Yoon,E.-J., Gwon,B., Liu,C., Kim,D., Won,D., Park,S.G., Choi,J.R.
            and Jeong,S.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-APR-2020) Research Institute of Bacterial Resistance,
            Yonsei University College of Medicine, 211, Eonjuro, Gangnam-Gu,
            Seoul 06273, Korea, Republic of
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: Oxford Nanopore and Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/27/2020 22:13:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 5,507
            CDSs (total)                      :: 5,385
            Genes (coding)                    :: 5,285
            CDSs (with protein)               :: 5,285
            Genes (RNA)                       :: 122
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 84
            ncRNAs                            :: 13
            Pseudo Genes (total)              :: 100
            CDSs (without protein)            :: 100
            Pseudo Genes (ambiguous residues) :: 0 of 100
            Pseudo Genes (frameshifted)       :: 47 of 100
            Pseudo Genes (incomplete)         :: 48 of 100
            Pseudo Genes (internal stop)      :: 19 of 100
            Pseudo Genes (multiple problems)  :: 12 of 100
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..9294
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="B16KP0089"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="pB16KP0089-2"
                     /geo_loc_name="South Korea: Gyeonggi"
                     /lat_lon="37.66 N 126.77 E"
                     /collection_date="2016"
                     /collected_by="Kor-GLASS"
     gene            join(9289..9294,1..1959)
                     /locus_tag="HJW79_27420"
     CDS             join(9289..9294,1..1959)
                     /locus_tag="HJW79_27420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="QJM18954.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     gene            1959..2690
                     /locus_tag="HJW79_27425"
     CDS             1959..2690
                     /locus_tag="HJW79_27425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication-relaxation family protein"
                     /protein_id="QJM18955.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="replication-relaxation family protein"
     gene            2697..3227
                     /locus_tag="HJW79_27430"
     CDS             2697..3227
                     /locus_tag="HJW79_27430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QJM18956.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(3255..3434)
                     /locus_tag="HJW79_27435"
     CDS             complement(3255..3434)
                     /locus_tag="HJW79_27435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="QJM18957.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            3503..3880
                     /locus_tag="HJW79_27440"
     CDS             3503..3880
                     /locus_tag="HJW79_27440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="entry exclusion protein 1"
                     /protein_id="QJM18958.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="entry exclusion protein 1"
     gene            complement(3942..4241)
                     /locus_tag="HJW79_27445"
     CDS             complement(3942..4241)
                     /locus_tag="HJW79_27445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="QJM18959.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(4231..4494)
                     /locus_tag="HJW79_27450"
     CDS             complement(4231..4494)
                     /locus_tag="HJW79_27450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid stabilization protein"
                     /protein_id="QJM18960.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="plasmid stabilization protein"
     gene            complement(4800..5219)
                     /gene="exc2"
                     /locus_tag="HJW79_27455"
     CDS             complement(4800..5219)
                     /gene="exc2"
                     /locus_tag="HJW79_27455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /protein_id="QJM18961.1"
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
                     /name="exc2"
     gene            5622..7307
                     /locus_tag="HJW79_27460"
     CDS             5622..7307
                     /locus_tag="HJW79_27460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="QJM18962.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="cloacin"
     gene            7317..7574
                     /locus_tag="HJW79_27465"
     CDS             7317..7574
                     /locus_tag="HJW79_27465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="QJM18963.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin"
     gene            7659..7808
                     /locus_tag="HJW79_27470"
     CDS             7659..7808
                     /locus_tag="HJW79_27470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="QJM18964.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     BGC             622..9294
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          complement(7912..8490)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          1960..2687
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.32e-150"
ORIGIN
        1 aatacggatt cgcttgcctg gaagtggcac attccggagc tggcccggca gatttatccg
       61 tgggtcagct ggctgtacca ggagtattac ggtctggccg gggctttcct agttatcggc
      121 ctgtttttcg gtctggctga actttgggcc ggacggatgc gttttgtggg gctgagtcat
      181 aaggagcgac gggagtatgc cgatcgctat aagcgcgata ataaacggcc agcgccattt
      241 tcggtgctgg cctcgctgga ttcgcccggg cggatggtca gggcacgtcg acatgtctgg
      301 aactacgcgt actggctgac cggcgcggcc ggtctggccc ttctgggggg gctggttgtc
      361 gccgtgttta tcgagagctg gggagaaacc gtcctgcgtc cggacctcta cgcaaacgca
      421 gattattacc tgctgcagcc ggctaacctg ttcgggattg cctggtgcgc gggcgggctg
      481 gctgtcggga ttgtgttggc gcggctgctg gcgttcctgc tgcttgacgg tcattttgcg
      541 gctgctgacg aggcggtgaa cgcgaaactg aatcaggaga gccggcgcag cagccagcgg
      601 acaggagaga tgaccgacgt gcgccacctg catttcgggg agccggtacc ggttaatgcg
      661 ctggccgatt tttcctcgga gcaggcccgg caggagcagg cggtgtttct gggtaaggat
      721 gagcagggca agccggtgct ggttccgcgt gatacctggc gcaagaccaa cattcagatc
      781 ctcggcctgc ccgggagcgg caagagcgtg atggccacca acgcgctcat tcgctgcgta
      841 cgcgatttcg gggacgcggt ggtgtacttc gaccccaaag gggacgcatg ggcgccgcac
      901 gtcttccggg cgcactgtcc ggacttcacc ctgctggatc tgcggccggg gaaaccggcg
      961 cagctgaatc tgttccgcga tctcgaccag tacgcgctga aaaacctgct gattgccggg
     1021 cttaacctgg gcgagaccgg cgacgtggcg gaccactacc gcatcagcga gcagaaagcg
     1081 gcgaagctga ttgcggagca gtttccgcag ggggcaaaca ttcagcaggt gctggcggcg
     1141 gcgtacgcgc tgccggaggc cctgaaaaag gacgtgaagg ggttgatcac taggctggaa
     1201 aacgtcgctg acctgagcgt cctgcagacg gacagtggca tcgatgtggc ggggattatc
     1261 aacggcggcg gctgcctgta cgttatcggc tcgatggacg acgaggcggt gatccgtgtg
     1321 caaaaaatgc tgtttgcccg ctgcgcgcaa atcatcattg cgcgggacga gttccgggag
     1381 tggccacacg tcagcgtgat gctcgatgaa attaaatatc tgctgtcgaa gtatgtactg
     1441 aacgcactgg ggacgctgcg cagccgggac tgcaatctgt tgctcgcgca ccagtcgctg
     1501 ggcgatttcg ggcagtgcgg gcaggatctg cccgctgaat ttgtgaaaac cacggtactg
     1561 gataacacgc cgatccgctg gttttaccgg gcggccagcc tggagtccgc gcagtgggcg
     1621 gcggggcaga ccggggaaat cagggtggac gtggagcgcc gccgtgccag ccgggaggcg
     1681 gggaacgtgg agcatatcag cggggacagc ttcatccaga aggaggcgcg gccgctgttt
     1741 gacgtgaaca ccctgcaaca cctgccggac gggttcgcgg tcatgaccgg gctgggtgtg
     1801 gcccggatgg cgttcagcag tccgctgcgg gttgagcgcc gggaaatccc gttgcagcgt
     1861 ttcccggtgc tggcgaaaac cgatcccctg gcggagttcc ggcccccggc cgacggcggc
     1921 gggccgaaag cggatgatga ttttgcgggg atttactgat ggcgctggag ctgtacaacg
     1981 tcagccacgc gaaacgacag gcgcggaacg cggagaaaac ccggctgacc ctgcgctggt
     2041 tgcgggaaga gctgtgttcc acggcggagc tggttgcgcg gcggctgggg attgcggcgg
     2101 tgcagccggt ctaccgcttc ctcgacagcc tggtggcgaa agggctgctg gtccggacca
     2161 aatatccggt ggacggccgt caggtcagcg tgtgggggct gacgccgcat ggcgtggcgt
     2221 tctcgttcga cgaggacgaa ccgctggcgg atgttattcc gtttcagccg tcaagggtgt
     2281 cggcagcaca tctgccgcac cggctggccg tgcaatccct gcgccttgat atggaagcca
     2341 gaggggccac cggctggcgc attctgcacc gtctgagtct taaaggcatg aaagtgccgg
     2401 acgccctggc ggagctggac ggtaaaacgg tggcgtttga ggtggagcgc accgtcaaga
     2461 gccgtcgccg gtatcaggaa gtggtgtccg ggtatctgtt caaccgcaaa gctaacggca
     2521 tcgatgaaat ctggtacatc tgcccggacc gggcgacgca ggtcagggtg cagcgggcaa
     2581 tcctgtcggt ggatgaaatc gtgaacccac agaccggcga ggcccgcaaa acggcagagc
     2641 tggatcgtga acggttgttt gcgtgcttta aatttatgac aacggagtga gggattatgg
     2701 cgctgtacat ggtatttatt gaagacgcgg aggaccggaa cggcgagcgc tgcatcatgc
     2761 cgaccagcga gcatctggaa gatatggtgg tgctcgcctg gcagaccggg gcgtatgttt
     2821 tctgttttgt cgaccgggcc cagcatctgg cgatgatgaa atccatcggg atgtatgacg
     2881 agcggctcaa cagcgacgaa aaagccacgt actttttcac tggtaaaaat ccgcaatggg
     2941 aacggaacaa acccacagga atgaagctgt gtgattacct ctatcgcaag gtggagcggt
     3001 tcgccatcga gaacggtgtg caggtggttg atgccgggaa gtgctcaccg gagcagatta
     3061 acgcgatgat tgacgtggtg agtgagcggc acggggaaag cgcggtgaac gagaagctga
     3121 aagcggagct gatgcgggaa tataacagcc gctattttaa cgtgccggta cctgaactgc
     3181 cggaggacaa acctgcccgc cggtggtggc cgttcggcaa aaaataaatg ccagcaccgg
     3241 ccatgccggt gctgttattc ctccccgagc ttatcccgca tcacctgcca gagtgtttcc
     3301 gcatcctcgt gtagccgctc gcacatgtcg gccggggtat ccatatccag ctcattcagt
     3361 ttatcgagca atagcagcga ctgctcctta ataaatttag ccatattgag ggctgttttt
     3421 tcctgttttg tcatgattct ttccttccgg gcatggtgtg cgcctgtcag gtatactgtc
     3481 tcaaaaatag cggggtgaga caatggcgtg ggtgacggtg agacaggcga cggaactgac
     3541 gggtaaagcc cgaagttccc tgtatcggga tatggcgaaa ggccgcgtat cataccgtac
     3601 ggaagctgat ggcggccggg tggtggatac cagcgagctt atccgggtgt acggtgagtt
     3661 aagacaggat gagactcacg agcgggacga gttgagactg tcgggtgaga ctgaaaaaat
     3721 ggcctccgac gcgttgatcg cggagataaa agcactcagg gaggaggtgg ccgggctacg
     3781 gcaggaaatg cagtccatga gactgctgga acacaaaccg gagacagcag agaccccggc
     3841 cggaacaccg cgccggtggt ggccgtgggg aaaacgctga cgcgctgtgc ttgtccaacc
     3901 ggcgacggcc acgcaatgaa ttgcgtcccc gtcaccggtt attagagaac aatatgggga
     3961 ttctggcgct ggccgaccac ggccagaacc cggacttttc tggtctggtc atcaacatca
     4021 tagaggacat gctgtcccat cagactgatc cggcgaacgt cctcgccata gcgtgagtcc
     4081 acttcataga gtcgcgggaa gtcggccagt ttgtccgccg cagcgagaac ccggtcggta
     4141 acgttctgcg catcccacag ggatgaattt tccgcgatat agtcaaacag cgtcgttaca
     4201 tcctcgatgg ctccctgctt ccattccacg tcatacggca tcgcgcagtt cctgataacg
     4261 gccatgcagg cgctggcgga gttgttccgt ggtcataccc ggacgcgtgt cagcacgggc
     4321 ggcggtcact ttggcgcgaa cctgatcttc atactctgcc tgggccagtt cttcgttagc
     4381 cagtcgctgc aacagcgcag ctttgtccgg gccaccttcc ggcagtatgc ggggcaggct
     4441 ttcagccagt tcccgaagaa agttggcgtt ttcgtagtgt gtagtgttgc tcattgcgga
     4501 gcctcccggg ttaatgcggc aatatgaagg aagtttagca gggggcggtc tgaaagaata
     4561 tggtcgtgtc agtcaggctg atgaagcaga aagtcggtaa aaaagggctt acggcatcca
     4621 ttttacgtca aaacatatgc catgcagttg cgtgcatagg catgcattag gataaaattt
     4681 atcgggcgcg tttccggcag ttttccgggg gggttgttgc ctgttttatc ccgtagccgc
     4741 cggaaacgcc ctgagcccgt ctgagcggtg cgcgtaatga cgcgttatgg taaatccact
     4801 tactgtctgc cttcatagcc atcgagataa acagctgaaa tggtgtcagc cagtagcctt
     4861 gattttttcg gtgtgaggtc tttgctgcgg taatcggtac ccgcaaattg tgttgtgcct
     4921 tggagtgagt ttaaaaattc ctgactgtga aactgctgaa tgcgttgctg cacatcactc
     4981 cgtgattttc cggtcgcttt atcctttgcg cccatatccc agaactgccg gaaaaaaggc
     5041 accatcattc gtgttgtgtc agctttctgg gtggaaaaat tgggatcaaa accgtcatct
     5101 gaagcatata cgtaatgccg ggtatgctgt tccacgctgc cctttggagc acaggcagtg
     5161 agagttgctg tcgctgttat catggcgata agacacagtt tgctgccgga acgtctcatg
     5221 agcgtctcct tacctttaat tcttttttct cattgagtta tatatccgca ggctatctta
     5281 tcatcagttt ctgaccgtgt tcagtgaccg aacaacccga accagacccc ccgtttcttt
     5341 tcctgtcccg gagggggctt tctggtatct catataatga tttcagtaaa acatactgag
     5401 gccggagaac ggcgccgttt gtgctggttt ttgttgcatc tggaggggat tgcgcatggt
     5461 gtgagtggct gtttttttga tcattttcac aaaaacgcaa atttacagac ttgacatgaa
     5521 aaacaaggca gcgtaatttt tatactgtat ataaaaccag tggttatatg tacagtattt
     5581 tattttagtt tattgtttta aaagtcaaag aggaaaagta tatgagtggc ggagacggac
     5641 gaggtccggg taattcaggt ctgggacaca atggtggtca ggccagtggg aatgtgaacg
     5701 gtacatcagg taaaggtggc ccttcatcag gtggtggtac ggatccaaac agcgggccgg
     5761 gctggggtac gacgcataca cctaacgggg atattcataa ctataacccg ggggagtttg
     5821 gtaacggcgg gagtaaaccc ggtggtaatg gcggtaacag cggcaatcat agcgggagct
     5881 ctggtggcgg acagtcttcg gccaccgcga tggccttcgg tctgcctgcc ctggccactc
     5941 cgggggctga aggactggct ttatccgttt ccggcgatgc gttgtcggcc gctgttgctg
     6001 atgtgctggc tgccctgaaa ggtccgttta agtttggtct gtgggggatt gcgatttacg
     6061 gagtgctgcc ttctgagata gcaaaagatg atccgaaaat gatgtcaaaa atcgtgacgt
     6121 cattgccggc agacacggta acggagacgc cggtcagctc cctgccgctg gaccaggcga
     6181 cggtcagcgt cactaaacgt gtggcggata ttgtgaagga cgagcggcag catattgcgg
     6241 ttgtcaccgg ccggccaatg agtgttcctg tggtggatgc gaaaccgaca aaacgtccgg
     6301 gggtattcag tgtgtcgatt ccgggtctcc cgtctctgca ggtgagcgta cctaaaggtg
     6361 ttccggccgc gaaagccccg ccaaaaggca ttattgctga aaaaggtgat tcacgtccgg
     6421 ctggttttac ggccggtggt aactcccgtg aggccgttat tcgtttcccg aaagagagcg
     6481 gacagaaacc ggtctatgtg tcggtgacgg atgttcttac tccggcacag gtaaaacagc
     6541 gtctggagga agaaaagcgt cgccagcagg catgggacgc tgctcacccg gaagaggggc
     6601 tgaaaagaga gtatgataaa gcgaaagctg agctggatgc tgaagataaa aatattgcga
     6661 ccttaaacag tcgcattgca tcgacagaga aggcgatccc cggtgcaagg gctgctgttc
     6721 aggaagccga taaaaaggta aaagaggcag aggcaaataa agatgatttt gtgacttata
     6781 acccgcctca tgaatatggc tccgggtggc aggatcaggt tcgctatctt gataaggata
     6841 ttcagaatca gaatgagaaa ttaaaagctg cccagacatc tttaaacgaa atgaatgaat
     6901 ccttatccag ggataaggct gcgctttccg gggcgatgga gagccggaaa caaaaggaga
     6961 aaaaagcgaa ggatgcagaa aataaattaa atgaggaaaa gaaaaaacct cgtaagggaa
     7021 ctaaagatta cggccatgat tattttcctg atcccaagac tgaagatatt aaggggttgg
     7081 gagagttgaa agagggtaaa cctaaaaccc ctaaacaagg tggtggtggt aagcgggccc
     7141 gatggtatgg tgataaaaag cgtaaaattt atgaatggga ttcccagcac ggtgagcttg
     7201 aagggtaccg cgccagtgat ggcgaacacc tcggggcatt cgatccaaaa acgggtaagc
     7261 aggttaaagg gccggatcca aaacgaaaca ttaaaaaata tctttaagag gtaaatatgg
     7321 ggcttaaatt acatattcat tggtttgata agaaaaccga agagtttaaa ggtggtgaat
     7381 actcaaaaga cttcggtgat gatggttctg tcattgaaag tctggggatg cctttaaagg
     7441 ataatattaa taatggttgg tttgatgttg aaaaatcatg ggtttcgata ttacagccac
     7501 actttaaaaa tgtaatcgat attagtaaat ttgattactt tgtatccttt gtttaccggg
     7561 atggtaactg gtaagcaaaa gttatcaagg atgatttgaa atacagactt ccggtgttca
     7621 gggatgaata ccggggtttt taaatacagg gaaggtatat gaaaaaggta aaggttgttt
     7681 ttctttttat attgattttt tcaggctttc ttctggtcgc atgtcaggca aactatatcc
     7741 gggatgttca gggtggaacg gtggcaccat cgtcctcctc tgaactgacg gggatcgcgg
     7801 ttcagtagaa aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatcttttg
     7861 ccctgtaaac gaaaaaacca cctggggagg tggtttgatc gaaggttaag tcagttgggg
     7921 aactgcttaa ccgtggtaac tggctttcgc agagcacagc aaccaaatct gtccttccag
     7981 tgtagccgga ctttggcgca cacttcaaga gcaaccgcgt gtttagctaa acaaatcctc
     8041 tgcgaactcc cagttaccaa tggctgctgc cagtggcgtt ttgcgtgctt ttccgggttg
     8101 gactcaagtg aacagttacc ggataaggcg cagcagtcgg gctgaacggg gggttcttgc
     8161 ttacagccca gcttggagcg aacgacctac accgagccga gataccagag tgtgagctat
     8221 gagaaagcgc cacacttccc gcaagggaga aaggcggaac aggtatccgg gaaacggcag
     8281 ggttggaaca ggagagcgca agagggagcg attcatcgga aacggtgatg atctttaagt
     8341 cctgtcgggt ttcgccactc ctgactgatt catggttgag ccaccggctc ccacagatgc
     8401 accgaaaaag cgtctgttta tgtgaactca gtcaggaggg cggagcctat ggaaaaacgc
     8461 cacctgcgtg gccttgccgt tttgcctcac atgttagtcc cctgcttatt cacggaatct
     8521 gtgggtaact ttgcatgtgt ccgcagcgcc cgccgcagtc tcacggccgg agcgtagcga
     8581 ccgagtgagc gaggaggcgc aatttccccg gcacctacaa gacggacacc ggacgcgctg
     8641 atgtggcata ttgtcccctg attaagtctt tatattccct gataataaat taccaggata
     8701 ggtgaatcat atcggttttt cgctgaacat tttacgttaa cctatctctg ttgctttttt
     8761 ctccttacgg agaaatacag gtcatccccg cgagggcgtg gctgacctca gggggatatc
     8821 ccctgcttac gctggctgga cgccaccgac gcacggtctc tccccctctt tctggctccg
     8881 tccggctgga cgccggccac gccagaaatt cacccggccc ccgtcaggct cacgcctgac
     8941 cacccacaaa aatccacggt gctggacgca cctggcgaag cagcaaagct gctcctgatt
     9001 ttgcgggtgg tcagccgctc gctatggcga actctgacgg gggccggaac accggaaaag
     9061 accgcactgg ggtgccgcct tttcctctca cacgctgggg cgtgctcgtt gttcctccgg
     9121 ggctgcgcct tttccgcatg gggcggaaag aggctggcct ccgtggtgaa agctgaacgc
     9181 aatcaccacg gacgtgaccg ccgccgccat gccttggggc atgtccgcgg cttgtgcagc
     9241 gggggctgca catcacgccg gcaaaccatc gtctgaagga gagagaacat gttt
//
