LOCUS       CP052497                9294 bp    DNA     circular BCT 04-MAY-2020
DEFINITION  Klebsiella pneumoniae strain B17KP0067 plasmid pB17KP0067-3,
            complete sequence.
ACCESSION   CP052497
VERSION     CP052497.1
DBLINK      BioProject: PRJNA625837
            BioSample: SAMN14609878
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 9294)
  AUTHORS   Yoon,E.-J., Gwon,B., Liu,C., Kim,D., Won,D., Park,S.G., Choi,J.R.
            and Jeong,S.H.
  TITLE     Built-in CTX-M extended-spectrum beta-lactamase gene in Klebsiella
            pneumoniae ensuring stable propagation of the multidrug-resistant
            pathogen in clinical settings
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9294)
  AUTHORS   Yoon,E.-J., Gwon,B., Liu,C., Kim,D., Won,D., Park,S.G., Choi,J.R.
            and Jeong,S.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-APR-2020) Research Institute of Bacterial Resistance,
            Yonsei University College of Medicine, 211, Eonjuro, Gangnam-Gu,
            Seoul 06273, Korea, Republic of
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: Oxford Nanopore and Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/27/2020 20:39:59
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 5,615
            CDSs (total)                      :: 5,489
            Genes (coding)                    :: 5,322
            CDSs (with protein)               :: 5,322
            Genes (RNA)                       :: 126
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 15
            Pseudo Genes (total)              :: 167
            CDSs (without protein)            :: 167
            Pseudo Genes (ambiguous residues) :: 0 of 167
            Pseudo Genes (frameshifted)       :: 84 of 167
            Pseudo Genes (incomplete)         :: 82 of 167
            Pseudo Genes (internal stop)      :: 30 of 167
            Pseudo Genes (multiple problems)  :: 28 of 167
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..9294
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="B17KP0067"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="pB17KP0067-3"
                     /geo_loc_name="South Korea: Gyeonggi"
                     /lat_lon="37.66 N 126.77 E"
                     /collection_date="2017"
                     /collected_by="Kor-GLASS"
     gene            join(8084..9294,1..754)
                     /locus_tag="HJW90_28025"
     CDS             join(8084..9294,1..754)
                     /locus_tag="HJW90_28025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="QJL69926.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     gene            754..1485
                     /locus_tag="HJW90_28030"
     CDS             754..1485
                     /locus_tag="HJW90_28030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication-relaxation family protein"
                     /protein_id="QJL69927.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="replication-relaxation family protein"
     gene            1492..2022
                     /locus_tag="HJW90_28035"
     CDS             1492..2022
                     /locus_tag="HJW90_28035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QJL69928.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(2050..2229)
                     /locus_tag="HJW90_28040"
     CDS             complement(2050..2229)
                     /locus_tag="HJW90_28040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="QJL69929.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            2298..2675
                     /locus_tag="HJW90_28045"
     CDS             2298..2675
                     /locus_tag="HJW90_28045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="entry exclusion protein 1"
                     /protein_id="QJL69930.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="entry exclusion protein 1"
     gene            complement(2737..3036)
                     /locus_tag="HJW90_28050"
     CDS             complement(2737..3036)
                     /locus_tag="HJW90_28050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="QJL69931.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(3026..3289)
                     /locus_tag="HJW90_28055"
     CDS             complement(3026..3289)
                     /locus_tag="HJW90_28055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid stabilization protein"
                     /protein_id="QJL69932.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="plasmid stabilization protein"
     gene            complement(3595..4014)
                     /gene="exc2"
                     /locus_tag="HJW90_28060"
     CDS             complement(3595..4014)
                     /gene="exc2"
                     /locus_tag="HJW90_28060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /protein_id="QJL69933.1"
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
                     /name="exc2"
     gene            4417..6102
                     /locus_tag="HJW90_28065"
     CDS             4417..6102
                     /locus_tag="HJW90_28065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="QJL69934.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="cloacin"
     gene            6112..6369
                     /locus_tag="HJW90_28070"
     CDS             6112..6369
                     /locus_tag="HJW90_28070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="QJL69935.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin"
     gene            6454..6603
                     /locus_tag="HJW90_28075"
     CDS             6454..6603
                     /locus_tag="HJW90_28075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="QJL69936.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     BGC             1..9294
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          complement(6707..7285)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          755..1482
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.32e-150"
ORIGIN
        1 cgctgacctg agcgtcctgc agacggacag tggcatcgat gtggcgggga ttatcaacgg
       61 cggcggctgc ctgtacgtta tcggctcgat ggacgacgag gcggtgatcc gtgtgcaaaa
      121 aatgctgttt gcccgctgcg cgcaaatcat cattgcgcgg gacgagttcc gggagtggcc
      181 acacgtcagc gtgatgctcg atgaaattaa atatctgctg tcgaagtatg tactgaacgc
      241 actggggacg ctgcgcagcc gggactgcaa tctgttgctc gcgcaccagt cgctgggcga
      301 tttcgggcag tgcgggcagg atctgcccgc tgaatttgtg aaaaccacgg tactggataa
      361 cacgccgatc cgctggtttt accgggcggc cagcctggag tccgcgcagt gggcggcggg
      421 gcagaccggg gaaatcaggg tggacgtgga gcgccgccgt gccagccggg aggcggggaa
      481 cgtggagcat atcagcgggg acagcttcat ccagaaggag gcgcggccgc tgtttgacgt
      541 gaacaccctg caacacctgc cggacgggtt cgcggtcatg accgggctgg gtgtggcccg
      601 gatggcgttc agcagtccgc tgcgggttga gcgccgggaa atcccgttgc agcgtttccc
      661 ggtgctggcg aaaaccgatc ccctggcgga gttccggccc ccggccgacg gcggcgggcc
      721 gaaagcggat gatgattttg cggggattta ctgatggcgc tggagctgta caacgtcagc
      781 cacgcgaaac gacaggcgcg gaacgcggag aaaacccggc tgaccctgcg ctggttgcgg
      841 gaagagctgt gttccacggc ggagctggtt gcgcggcggc tggggattgc ggcggtgcag
      901 ccggtctacc gcttcctcga cagcctggtg gcgaaagggc tgctggtccg gaccaaatat
      961 ccggtggacg gccgtcaggt cagcgtgtgg gggctgacgc cgcatggcgt ggcgttctcg
     1021 ttcgacgagg acgaaccgct ggcggatgtt attccgtttc agccgtcaag ggtgtcggca
     1081 gcacatctgc cgcaccggct ggccgtgcaa tccctgcgcc ttgatatgga agccagaggg
     1141 gccaccggct ggcgcattct gcaccgtctg agtcttaaag gcatgaaagt gccggacgcc
     1201 ctggcggagc tggacggtaa aacggtggcg tttgaggtgg agcgcaccgt caagagccgt
     1261 cgccggtatc aggaagtggt gtccgggtat ctgttcaacc gcaaagctaa cggcatcgat
     1321 gaaatctggt acatctgccc ggaccgggcg acgcaggtca gggtgcagcg ggcaatcctg
     1381 tcggtggatg aaatcgtgaa cccacagacc ggcgaggccc gcaaaacggc agagctggat
     1441 cgtgaacggt tgtttgcgtg ctttaaattt atgacaacgg agtgagggat tatggcgctg
     1501 tacatggtat ttattgaaga cgcggaggac cggaacggcg agcgctgcat catgccgacc
     1561 agcgagcatc tggaagatat ggtggtgctc gcctggcaga ccggggcgta tgttttctgt
     1621 tttgtcgacc gggcccagca tctggcgatg atgaaatcca tcgggatgta tgacgagcgg
     1681 ctcaacagcg acgaaaaagc cacgtacttt ttcactggta aaaatccgca atgggaacgg
     1741 aacaaaccca caggaatgaa gctgtgtgat tacctctatc gcaaggtgga gcggttcgcc
     1801 atcgagaacg gtgtgcaggt ggttgatgcc gggaagtgct caccggagca gattaacgcg
     1861 atgattgacg tggtgagtga gcggcacggg gaaagcgcgg tgaacgagaa gctgaaagcg
     1921 gagctgatgc gggaatataa cagccgctat tttaacgtgc cggtacctga actgccggag
     1981 gacaaacctg cccgccggtg gtggccgttc ggcaaaaaat aaatgccagc accggccatg
     2041 ccggtgctgt tattcctccc cgagcttatc ccgcatcacc tgccagagtg tttccgcatc
     2101 ctcgtgtagc cgctcgcaca tgtcggccgg ggtatccata tccagctcat tcagtttatc
     2161 gagcaatagc agcgactgct ccttaataaa tttagccata ttgagggctg ttttttcctg
     2221 ttttgtcatg attctttcct tccgggcatg gtgtgcgcct gtcaggtata ctgtctcaaa
     2281 aatagcgggg tgagacaatg gcgtgggtga cggtgagaca ggcgacggaa ctgacgggta
     2341 aagcccgaag ttccctgtat cgggatatgg cgaaaggccg cgtatcatac cgtacggaag
     2401 ctgatggcgg ccgggtggtg gataccagcg agcttatccg ggtgtacggt gagttaagac
     2461 aggatgagac tcacgagcgg gacgagttga gactgtcggg tgagactgaa aaaatggcct
     2521 ccgacgcgtt gatcgcggag ataaaagcac tcagggagga ggtggccggg ctacggcagg
     2581 aaatgcagtc catgagactg ctggaacaca aaccggagac agcagagacc ccggccggaa
     2641 caccgcgccg gtggtggccg tggggaaaac gctgacgcgc tgtgcttgtc caaccggcga
     2701 cggccacgca atgaattgcg tccccgtcac cggttattag agaacaatat ggggattctg
     2761 gcgctggccg accacggcca gaacccggac ttttctggtc tggtcatcaa catcatagag
     2821 gacatgctgt cccatcagac tgatccggcg aacgtcctcg ccatagcgtg agtccacttc
     2881 atagagtcgc gggaagtcgg ccagtttgtc cgccgcagcg agaacccggt cggtaacgtt
     2941 ctgcgcatcc cacagggatg aattttccgc gatatagtca aacagcgtcg ttacatcctc
     3001 gatggctccc tgcttccatt ccacgtcata cggcatcgcg cagttcctga taacggccat
     3061 gcaggcgctg gcggagttgt tccgtggtca tacccggacg cgtgtcagca cgggcggcgg
     3121 tcactttggc gcgaacctga tcttcatact ctgcctgggc cagttcttcg ttagccagtc
     3181 gctgcaacag cgcagctttg tccgggccac cttccggcag tatgcggggc aggctttcag
     3241 ccagttcccg aagaaagttg gcgttttcgt agtgtgtagt gttgctcatt gcggagcctc
     3301 ccgggttaat gcggcaatat gaaggaagtt tagcaggggg cggtctgaaa gaatatggtc
     3361 gtgtcagtca ggctgatgaa gcagaaagtc ggtaaaaaag ggcttacggc atccatttta
     3421 cgtcaaaaca tatgccatgc agttgcgtgc ataggcatgc attaggataa aatttatcgg
     3481 gcgcgtttcc ggcagttttc cgggggggtt gttgcctgtt ttatcccgta gccgccggaa
     3541 acgccctgag cccgtctgag cggtgcgcgt aatgacgcgt tatggtaaat ccacttactg
     3601 tctgccttca tagccatcga gataaacagc tgaaatggtg tcagccagta gccttgattt
     3661 tttcggtgtg aggtctttgc tgcggtaatc ggtacccgca aattgtgttg tgccttggag
     3721 tgagtttaaa aattcctgac tgtgaaactg ctgaatgcgt tgctgcacat cactccgtga
     3781 ttttccggtc gctttatcct ttgcgcccat atcccagaac tgccggaaaa aaggcaccat
     3841 cattcgtgtt gtgtcagctt tctgggtgga aaaattggga tcaaaaccgt catctgaagc
     3901 atatacgtaa tgccgggtat gctgttccac gctgcccttt ggagcacagg cagtgagagt
     3961 tgctgtcgct gttatcatgg cgataagaca cagtttgctg ccggaacgtc tcatgagcgt
     4021 ctccttacct ttaattcttt tttctcattg agttatatat ccgcaggcta tcttatcatc
     4081 agtttctgac cgtgttcagt gaccgaacaa cccgaaccag accccccgtt tcttttcctg
     4141 tcccggaggg ggctttctgg tatctcatat aatgatttca gtaaaacata ctgaggccgg
     4201 agaacggcgc cgtttgtgct ggtttttgtt gcatctggag gggattgcgc atggtgtgag
     4261 tggctgtttt tttgatcatt ttcacaaaaa cgcaaattta cagacttgac atgaaaaaca
     4321 aggcagcgta atttttatac tgtatataaa accagtggtt atatgtacag tattttattt
     4381 tagtttattg ttttaaaagt caaagaggaa aagtatatga gtggcggaga cggacgaggt
     4441 ccgggtaatt caggtctggg acacaatggt ggtcaggcca gtgggaatgt gaacggtaca
     4501 tcaggtaaag gtggcccttc atcaggtggt ggtacggatc caaacagcgg gccgggctgg
     4561 ggtacgacgc atacacctaa cggggatatt cataactata acccggggga gtttggtaac
     4621 ggcgggagta aacccggtgg taatggcggt aacagcggca atcatagcgg gagctctggt
     4681 ggcggacagt cttcggccac cgcgatggcc ttcggtctgc ctgccctggc cactccgggg
     4741 gctgaaggac tggctttatc cgtttccggc gatgcgttgt cggccgctgt tgctgatgtg
     4801 ctggctgccc tgaaaggtcc gtttaagttt ggtctgtggg ggattgcgat ttacggagtg
     4861 ctgccttctg agatagcaaa agatgatccg aaaatgatgt caaaaatcgt gacgtcattg
     4921 ccggcagaca cggtaacgga gacgccggtc agctccctgc cgctggacca ggcgacggtc
     4981 agcgtcacta aacgtgtggc ggatattgtg aaggacgagc ggcagcatat tgcggttgtc
     5041 accggccggc caatgagtgt tcctgtggtg gatgcgaaac cgacaaaacg tccgggggta
     5101 ttcagtgtgt cgattccggg tctcccgtct ctgcaggtga gcgtacctaa aggtgttccg
     5161 gccgcgaaag ccccgccaaa aggcattatt gctgaaaaag gtgattcacg tccggctggt
     5221 tttacggccg gtggtaactc ccgtgaggcc gttattcgtt tcccgaaaga gagcggacag
     5281 aaaccggtct atgtgtcggt gacggatgtt cttactccgg cacaggtaaa acagcgtctg
     5341 gaggaagaaa agcgtcgcca gcaggcatgg gacgctgctc acccggaaga ggggctgaaa
     5401 agagagtatg ataaagcgaa agctgagctg gatgctgaag ataaaaatat tgcgacctta
     5461 aacagtcgca ttgcatcgac agagaaggcg atccccggtg caagggctgc tgttcaggaa
     5521 gccgataaaa aggtaaaaga ggcagaggca aataaagatg attttgtgac ttataacccg
     5581 cctcatgaat atggctccgg gtggcaggat caggttcgct atcttgataa ggatattcag
     5641 aatcagaatg agaaattaaa agctgcccag acatctttaa acgaaatgaa tgaatcctta
     5701 tccagggata aggctgcgct ttccggggcg atggagagcc ggaaacaaaa ggagaaaaaa
     5761 gcgaaggatg cagaaaataa attaaatgag gaaaagaaaa aacctcgtaa gggaactaaa
     5821 gattacggcc atgattattt tcctgatccc aagactgaag atattaaggg gttgggagag
     5881 ttgaaagagg gtaaacctaa aacccctaaa caaggtggtg gtggtaagcg ggcccgatgg
     5941 tatggtgata aaaagcgtaa aatttatgaa tgggattccc agcacggtga gcttgaaggg
     6001 taccgcgcca gtgatggcga acacctcggg gcattcgatc caaaaacggg taagcaggtt
     6061 aaagggccgg atccaaaacg aaacattaaa aaatatcttt aagaggtaaa tatggggctt
     6121 aaattacata ttcattggtt tgataagaaa accgaagagt ttaaaggtgg tgaatactca
     6181 aaagacttcg gtgatgatgg ttctgtcatt gaaagtctgg ggatgccttt aaaggataat
     6241 attaataatg gttggtttga tgttgaaaaa tcatgggttt cgatattaca gccacacttt
     6301 aaaaatgtaa tcgatattag taaatttgat tactttgtat cctttgttta ccgggatggt
     6361 aactggtaag caaaagttat caaggatgat ttgaaataca gacttccggt gttcagggat
     6421 gaataccggg gtttttaaat acagggaagg tatatgaaaa aggtaaaggt tgtttttctt
     6481 tttatattga ttttttcagg ctttcttctg gtcgcatgtc aggcaaacta tatccgggat
     6541 gttcagggtg gaacggtggc accatcgtcc tcctctgaac tgacggggat cgcggttcag
     6601 tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc ttttgccctg
     6661 taaacgaaaa aaccacctgg ggaggtggtt tgatcgaagg ttaagtcagt tggggaactg
     6721 cttaaccgtg gtaactggct ttcgcagagc acagcaacca aatctgtcct tccagtgtag
     6781 ccggactttg gcgcacactt caagagcaac cgcgtgttta gctaaacaaa tcctctgcga
     6841 actcccagtt accaatggct gctgccagtg gcgttttgcg tgcttttccg ggttggactc
     6901 aagtgaacag ttaccggata aggcgcagca gtcgggctga acggggggtt cttgcttaca
     6961 gcccagcttg gagcgaacga cctacaccga gccgagatac cagagtgtga gctatgagaa
     7021 agcgccacac ttcccgcaag ggagaaaggc ggaacaggta tccgggaaac ggcagggttg
     7081 gaacaggaga gcgcaagagg gagcgattca tcggaaacgg tgatgatctt taagtcctgt
     7141 cgggtttcgc cactcctgac tgattcatgg ttgagccacc ggctcccaca gatgcaccga
     7201 aaaagcgtct gtttatgtga actcagtcag gagggcggag cctatggaaa aacgccacct
     7261 gcgtggcctt gccgttttgc ctcacatgtt agtcccctgc ttattcacgg aatctgtggg
     7321 taactttgca tgtgtccgca gcgcccgccg cagtctcacg gccggagcgt agcgaccgag
     7381 tgagcgagga ggcgcaattt ccccggcacc tacaagacgg acaccggacg cgctgatgtg
     7441 gcatattgtc ccctgattaa gtctttatat tccctgataa taaattacca ggataggtga
     7501 atcatatcgg tttttcgctg aacattttac gttaacctat ctctgttgct tttttctcct
     7561 tacggagaaa tacaggtcat ccccgcgagg gcgtggctga cctcaggggg atatcccctg
     7621 cttacgctgg ctggacgcca ccgacgcacg gtctctcccc ctctttctgg ctccgtccgg
     7681 ctggacgccg gccacgccag aaattcaccc ggcccccgtc aggctcacgc ctgaccaccc
     7741 acaaaaatcc acggtgctgg acgcacctgg cgaagcagca aagctgctcc tgattttgcg
     7801 ggtggtcagc cgctcgctat ggcgaactct gacgggggcc ggaacaccgg aaaagaccgc
     7861 actggggtgc cgccttttcc tctcacacgc tggggcgtgc tcgttgttcc tccggggctg
     7921 cgccttttcc gcatggggcg gaaagaggct ggcctccgtg gtgaaagctg aacgcaatca
     7981 ccacggacgt gaccgccgcc gccatgcctt ggggcatgtc cgcggcttgt gcagcggggg
     8041 ctgcacatca cgccggcaaa ccatcgtctg aaggagagag aacatgttta atacggattc
     8101 gcttgcctgg aagtggcaca ttccggagct ggcccggcag atttatccgt gggtcagctg
     8161 gctgtaccag gagtattacg gtctggccgg ggctttccta gttatcggcc tgtttttcgg
     8221 tctggctgaa ctttgggccg gacggatgcg ttttgtgggg ctgagtcata aggagcgacg
     8281 ggagtatgcc gatcgctata agcgcgataa taaacggcca gcgccatttt cggtgctggc
     8341 ctcgctggat tcgcccgggc ggatggtcag ggcacgtcga catgtctgga actacgcgta
     8401 ctggctgacc ggcgcggccg gtctggccct tctggggggg ctggttgtcg ccgtgtttat
     8461 cgagagctgg ggagaaaccg tcctgcgtcc ggacctctac gcaaacgcag attattacct
     8521 gctgcagccg gctaacctgt tcgggattgc ctggtgcgcg ggcgggctgg ctgtcgggat
     8581 tgtgttggcg cggctgctgg cgttcctgct gcttgacggt cattttgcgg ctgctgacga
     8641 ggcggtgaac gcgaaactga atcaggagag ccggcgcagc agccagcgga caggagagat
     8701 gaccgacgtg cgccacctgc atttcgggga gccggtaccg gttaatgcgc tggccgattt
     8761 ttcctcggag caggcccggc aggagcaggc ggtgtttctg ggtaaggatg agcagggcaa
     8821 gccggtgctg gttccgcgtg atacctggcg caagaccaac attcagatcc tcggcctgcc
     8881 cgggagcggc aagagcgtga tggccaccaa cgcgctcatt cgctgcgtac gcgatttcgg
     8941 ggacgcggtg gtgtacttcg accccaaagg ggacgcatgg gcgccgcacg tcttccgggc
     9001 gcactgtccg gacttcaccc tgctggatct gcggccgggg aaaccggcgc agctgaatct
     9061 gttccgcgat ctcgaccagt acgcgctgaa aaacctgctg attgccgggc ttaacctggg
     9121 cgagaccggc gacgtggcgg accactaccg catcagcgag cagaaagcgg cgaagctgat
     9181 tgcggagcag tttccgcagg gggcaaacat tcagcaggtg ctggcggcgg cgtacgcgct
     9241 gccggaggcc ctgaaaaagg acgtgaaggg gttgatcact aggctggaaa acgt
//
