LOCUS       CP052486                9294 bp    DNA     circular BCT 04-MAY-2020
DEFINITION  Klebsiella pneumoniae strain C16KP0036 plasmid pC16KP0036-2,
            complete sequence.
ACCESSION   CP052486
VERSION     CP052486.1
DBLINK      BioProject: PRJNA625837
            BioSample: SAMN14609881
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 9294)
  AUTHORS   Yoon,E.-J., Gwon,B., Liu,C., Kim,D., Won,D., Park,S.G., Choi,J.R.
            and Jeong,S.H.
  TITLE     Built-in CTX-M extended-spectrum beta-lactamase gene in Klebsiella
            pneumoniae ensuring stable propagation of the multidrug-resistant
            pathogen in clinical settings
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9294)
  AUTHORS   Yoon,E.-J., Gwon,B., Liu,C., Kim,D., Won,D., Park,S.G., Choi,J.R.
            and Jeong,S.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-APR-2020) Research Institute of Bacterial Resistance,
            Yonsei University College of Medicine, 211, Eonjuro, Gangnam-Gu,
            Seoul 06273, Korea, Republic of
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: Oxford Nanopore and Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/27/2020 21:22:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 5,276
            CDSs (total)                      :: 5,154
            Genes (coding)                    :: 5,060
            CDSs (with protein)               :: 5,060
            Genes (RNA)                       :: 122
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 84
            ncRNAs                            :: 13
            Pseudo Genes (total)              :: 94
            CDSs (without protein)            :: 94
            Pseudo Genes (ambiguous residues) :: 0 of 94
            Pseudo Genes (frameshifted)       :: 48 of 94
            Pseudo Genes (incomplete)         :: 42 of 94
            Pseudo Genes (internal stop)      :: 13 of 94
            Pseudo Genes (multiple problems)  :: 8 of 94
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..9294
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="C16KP0036"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="pC16KP0036-2"
                     /geo_loc_name="South Korea: Gangwon"
                     /lat_lon="37.82 N 128.16 E"
                     /collection_date="2016"
                     /collected_by="Kor-GLASS"
     gene            join(8621..9294,1..58)
                     /locus_tag="HJW93_26330"
     CDS             join(8621..9294,1..58)
                     /locus_tag="HJW93_26330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication-relaxation family protein"
                     /protein_id="QJL42746.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="replication-relaxation family protein"
     gene            65..595
                     /locus_tag="HJW93_26335"
     CDS             65..595
                     /locus_tag="HJW93_26335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QJL42736.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(623..802)
                     /locus_tag="HJW93_26340"
     CDS             complement(623..802)
                     /locus_tag="HJW93_26340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="QJL42737.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            871..1248
                     /locus_tag="HJW93_26345"
     CDS             871..1248
                     /locus_tag="HJW93_26345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="entry exclusion protein 1"
                     /protein_id="QJL42738.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="entry exclusion protein 1"
     gene            complement(1310..1609)
                     /locus_tag="HJW93_26350"
     CDS             complement(1310..1609)
                     /locus_tag="HJW93_26350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="QJL42739.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(1599..1862)
                     /locus_tag="HJW93_26355"
     CDS             complement(1599..1862)
                     /locus_tag="HJW93_26355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid stabilization protein"
                     /protein_id="QJL42740.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="plasmid stabilization protein"
     gene            complement(2168..2587)
                     /gene="exc2"
                     /locus_tag="HJW93_26360"
     CDS             complement(2168..2587)
                     /gene="exc2"
                     /locus_tag="HJW93_26360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /protein_id="QJL42741.1"
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
                     /name="exc2"
     gene            2990..4675
                     /locus_tag="HJW93_26365"
     CDS             2990..4675
                     /locus_tag="HJW93_26365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="QJL42742.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="cloacin"
     gene            4685..4942
                     /locus_tag="HJW93_26370"
     CDS             4685..4942
                     /locus_tag="HJW93_26370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="QJL42743.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin"
     gene            5027..5176
                     /locus_tag="HJW93_26375"
     CDS             5027..5176
                     /locus_tag="HJW93_26375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="QJL42744.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            6657..8621
                     /locus_tag="HJW93_26380"
     CDS             6657..8621
                     /locus_tag="HJW93_26380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="QJL42745.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     BGC             1..9294
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          complement(5280..5858)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          8622..9292
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="92.0"
                     /evalue="1.22e-136"
ORIGIN
        1 ggcagagctg gatcgtgaac ggttgtttgc gtgctttaaa tttatgacaa cggagtgagg
       61 gattatggcg ctgtacatgg tatttattga agacgcggag gaccggaacg gcgagcgctg
      121 catcatgccg accagcgagc atctggaaga tatggtggtg ctcgcctggc agaccggggc
      181 gtatgttttc tgttttgtcg accgggccca gcatctggcg atgatgaaat ccatcgggat
      241 gtatgacgag cggctcaaca gcgacgaaaa agccacgtac tttttcactg gtaaaaatcc
      301 gcaatgggaa cggaacaaac ccacaggaat gaagctgtgt gattacctct atcgcaaggt
      361 ggagcggttc gccatcgaga acggtgtgca ggtggttgat gccgggaagt gctcaccgga
      421 gcagattaac gcgatgattg acgtggtgag tgagcggcac ggggaaagcg cggtgaacga
      481 gaagctgaaa gcggagctga tgcgggaata taacagccgc tattttaacg tgccggtacc
      541 tgaactgccg gaggacaaac ctgcccgccg gtggtggccg ttcggcaaaa aataaatgcc
      601 agcaccggcc atgccggtgc tgttattcct ccccgagctt atcccgcatc acctgccaga
      661 gtgtttccgc atcctcgtgt agccgctcgc acatgtcggc cggggtatcc atatccagct
      721 cattcagttt atcgagcaat agcagcgact gctccttaat aaatttagcc atattgaggg
      781 ctgttttttc ctgttttgtc atgattcttt ccttccgggc atggtgtgcg cctgtcaggt
      841 atactgtctc aaaaatagcg gggtgagaca atggcgtggg tgacggtgag acaggcgacg
      901 gaactgacgg gtaaagcccg aagttccctg tatcgggata tggcgaaagg ccgcgtatca
      961 taccgtacgg aagctgatgg cggccgggtg gtggatacca gcgagcttat ccgggtgtac
     1021 ggtgagttaa gacaggatga gactcacgag cgggacgagt tgagactgtc gggtgagact
     1081 gaaaaaatgg cctccgacgc gttgatcgcg gagataaaag cactcaggga ggaggtggcc
     1141 gggctacggc aggaaatgca gtccatgaga ctgctggaac acaaaccgga gacagcagag
     1201 accccggccg gaacaccgcg ccggtggtgg ccgtggggaa aacgctgacg cgctgtgctt
     1261 gtccaaccgg cgacggccac gcaatgaatt gcgtccccgt caccggttat tagagaacaa
     1321 tatggggatt ctggcgctgg ccgaccacgg ccagaacccg gacttttctg gtctggtcat
     1381 caacatcata gaggacatgc tgtcccatca gactgatccg gcgaacgtcc tcgccatagc
     1441 gtgagtccac ttcatagagt cgcgggaagt cggccagttt gtccgccgca gcgagaaccc
     1501 ggtcggtaac gttctgcgca tcccacaggg atgaattttc cgcgatatag tcaaacagcg
     1561 tcgttacatc ctcgatggct ccctgcttcc attccacgtc atacggcatc gcgcagttcc
     1621 tgataacggc catgcaggcg ctggcggagt tgttccgtgg tcatacccgg acgcgtgtca
     1681 gcacgggcgg cggtcacttt ggcgcgaacc tgatcttcat actctgcctg ggccagttct
     1741 tcgttagcca gtcgctgcaa cagcgcagct ttgtccgggc caccttccgg cagtatgcgg
     1801 ggcaggcttt cagccagttc ccgaagaaag ttggcgtttt cgtagtgtgt agtgttgctc
     1861 attgcggagc ctcccgggtt aatgcggcaa tatgaaggaa gtttagcagg gggcggtctg
     1921 aaagaatatg gtcgtgtcag tcaggctgat gaagcagaaa gtcggtaaaa aagggcttac
     1981 ggcatccatt ttacgtcaaa acatatgcca tgcagttgcg tgcataggca tgcattagga
     2041 taaaatttat cgggcgcgtt tccggcagtt ttccgggggg gttgttgcct gttttatccc
     2101 gtagccgccg gaaacgccct gagcccgtct gagcggtgcg cgtaatgacg cgttatggta
     2161 aatccactta ctgtctgcct tcatagccat cgagataaac agctgaaatg gtgtcagcca
     2221 gtagccttga ttttttcggt gtgaggtctt tgctgcggta atcggtaccc gcaaattgtg
     2281 ttgtgccttg gagtgagttt aaaaattcct gactgtgaaa ctgctgaatg cgttgctgca
     2341 catcactccg tgattttccg gtcgctttat cctttgcgcc catatcccag aactgccgga
     2401 aaaaaggcac catcattcgt gttgtgtcag ctttctgggt ggaaaaattg ggatcaaaac
     2461 cgtcatctga agcatatacg taatgccggg tatgctgttc cacgctgccc tttggagcac
     2521 aggcagtgag agttgctgtc gctgttatca tggcgataag acacagtttg ctgccggaac
     2581 gtctcatgag cgtctcctta cctttaattc ttttttctca ttgagttata tatccgcagg
     2641 ctatcttatc atcagtttct gaccgtgttc agtgaccgaa caacccgaac cagacccccc
     2701 gtttcttttc ctgtcccgga gggggctttc tggtatctca tataatgatt tcagtaaaac
     2761 atactgaggc cggagaacgg cgccgtttgt gctggttttt gttgcatctg gaggggattg
     2821 cgcatggtgt gagtggctgt ttttttgatc attttcacaa aaacgcaaat ttacagactt
     2881 gacatgaaaa acaaggcagc gtaattttta tactgtatat aaaaccagtg gttatatgta
     2941 cagtatttta ttttagttta ttgttttaaa agtcaaagag gaaaagtata tgagtggcgg
     3001 agacggacga ggtccgggta attcaggtct gggacacaat ggtggtcagg ccagtgggaa
     3061 tgtgaacggt acatcaggta aaggtggccc ttcatcaggt ggtggtacgg atccaaacag
     3121 cgggccgggc tggggtacga cgcatacacc taacggggat attcataact ataacccggg
     3181 ggagtttggt aacggcggga gtaaacccgg tggtaatggc ggtaacagcg gcaatcatag
     3241 cgggagctct ggtggcggac agtcttcggc caccgcgatg gccttcggtc tgcctgccct
     3301 ggccactccg ggggctgaag gactggcttt atccgtttcc ggcgatgcgt tgtcggccgc
     3361 tgttgctgat gtgctggctg ccctgaaagg tccgtttaag tttggtctgt gggggattgc
     3421 gatttacgga gtgctgcctt ctgagatagc aaaagatgat ccgaaaatga tgtcaaaaat
     3481 cgtgacgtca ttgccggcag acacggtaac ggagacgccg gtcagctccc tgccgctgga
     3541 ccaggcgacg gtcagcgtca ctaaacgtgt ggcggatatt gtgaaggacg agcggcagca
     3601 tattgcggtt gtcaccggcc ggccaatgag tgttcctgtg gtggatgcga aaccgacaaa
     3661 acgtccgggg gtattcagtg tgtcgattcc gggtctcccg tctctgcagg tgagcgtacc
     3721 taaaggtgtt ccggccgcga aagccccgcc aaaaggcatt attgctgaaa aaggtgattc
     3781 acgtccggct ggttttacgg ccggtggtaa ctcccgtgag gccgttattc gtttcccgaa
     3841 agagagcgga cagaaaccgg tctatgtgtc ggtgacggat gttcttactc cggcacaggt
     3901 aaaacagcgt ctggaggaag aaaagcgtcg ccagcaggca tgggacgctg ctcacccgga
     3961 agaggggctg aaaagagagt atgataaagc gaaagctgag ctggatgctg aagataaaaa
     4021 tattgcgacc ttaaacagtc gcattgcatc gacagagaag gcgatccccg gtgcaagggc
     4081 tgctgttcag gaagccgata aaaaggtaaa agaggcagag gcaaataaag atgattttgt
     4141 gacttataac ccgcctcatg aatatggctc cgggtggcag gatcaggttc gctatcttga
     4201 taaggatatt cagaatcaga atgagaaatt aaaagctgcc cagacatctt taaacgaaat
     4261 gaatgaatcc ttatccaggg ataaggctgc gctttccggg gcgatggaga gccggaaaca
     4321 aaaggagaaa aaagcgaagg atgcagaaaa taaattaaat gaggaaaaga aaaaacctcg
     4381 taagggaact aaagattacg gccatgatta ttttcctgat cccaagactg aagatattaa
     4441 ggggttggga gagttgaaag agggtaaacc taaaacccct aaacaaggtg gtggtggtaa
     4501 gcgggcccga tggtatggtg ataaaaagcg taaaatttat gaatgggatt cccagcacgg
     4561 tgagcttgaa gggtaccgcg ccagtgatgg cgaacacctc ggggcattcg atccaaaaac
     4621 gggtaagcag gttaaagggc cggatccaaa acgaaacatt aaaaaatatc tttaagaggt
     4681 aaatatgggg cttaaattac atattcattg gtttgataag aaaaccgaag agtttaaagg
     4741 tggtgaatac tcaaaagact tcggtgatga tggttctgtc attgaaagtc tggggatgcc
     4801 tttaaaggat aatattaata atggttggtt tgatgttgaa aaatcatggg tttcgatatt
     4861 acagccacac tttaaaaatg taatcgatat tagtaaattt gattactttg tatcctttgt
     4921 ttaccgggat ggtaactggt aagcaaaagt tatcaaggat gatttgaaat acagacttcc
     4981 ggtgttcagg gatgaatacc ggggttttta aatacaggga aggtatatga aaaaggtaaa
     5041 ggttgttttt ctttttatat tgattttttc aggctttctt ctggtcgcat gtcaggcaaa
     5101 ctatatccgg gatgttcagg gtggaacggt ggcaccatcg tcctcctctg aactgacggg
     5161 gatcgcggtt cagtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta
     5221 atcttttgcc ctgtaaacga aaaaaccacc tggggaggtg gtttgatcga aggttaagtc
     5281 agttggggaa ctgcttaacc gtggtaactg gctttcgcag agcacagcaa ccaaatctgt
     5341 ccttccagtg tagccggact ttggcgcaca cttcaagagc aaccgcgtgt ttagctaaac
     5401 aaatcctctg cgaactccca gttaccaatg gctgctgcca gtggcgtttt gcgtgctttt
     5461 ccgggttgga ctcaagtgaa cagttaccgg ataaggcgca gcagtcgggc tgaacggggg
     5521 gttcttgctt acagcccagc ttggagcgaa cgacctacac cgagccgaga taccagagtg
     5581 tgagctatga gaaagcgcca cacttcccgc aagggagaaa ggcggaacag gtatccggga
     5641 aacggcaggg ttggaacagg agagcgcaag agggagcgat tcatcggaaa cggtgatgat
     5701 ctttaagtcc tgtcgggttt cgccactcct gactgattca tggttgagcc accggctccc
     5761 acagatgcac cgaaaaagcg tctgtttatg tgaactcagt caggagggcg gagcctatgg
     5821 aaaaacgcca cctgcgtggc cttgccgttt tgcctcacat gttagtcccc tgcttattca
     5881 cggaatctgt gggtaacttt gcatgtgtcc gcagcgcccg ccgcagtctc acggccggag
     5941 cgtagcgacc gagtgagcga ggaggcgcaa tttccccggc acctacaaga cggacaccgg
     6001 acgcgctgat gtggcatatt gtcccctgat taagtcttta tattccctga taataaatta
     6061 ccaggatagg tgaatcatat cggtttttcg ctgaacattt tacgttaacc tatctctgtt
     6121 gcttttttct ccttacggag aaatacaggt catccccgcg agggcgtggc tgacctcagg
     6181 gggatatccc ctgcttacgc tggctggacg ccaccgacgc acggtctctc cccctctttc
     6241 tggctccgtc cggctggacg ccggccacgc cagaaattca cccggccccc gtcaggctca
     6301 cgcctgacca cccacaaaaa tccacggtgc tggacgcacc tggcgaagca gcaaagctgc
     6361 tcctgatttt gcgggtggtc agccgctcgc tatggcgaac tctgacgggg gccggaacac
     6421 cggaaaagac cgcactgggg tgccgccttt tcctctcaca cgctggggcg tgctcgttgt
     6481 tcctccgggg ctgcgccttt tccgcatggg gcggaaagag gctggcctcc gtggtgaaag
     6541 ctgaacgcaa tcaccacgga cgtgaccgcc gccgccatgc cttggggcat gtccgcggct
     6601 tgtgcagcgg gggctgcaca tcacgccggc aaaccatcgt ctgaaggaga gagaacatgt
     6661 ttaatacgga ttcgcttgcc tggaagtggc acattccgga gctggcccgg cagatttatc
     6721 cgtgggtcag ctggctgtac caggagtatt acggtctggc cggggctttc ctagttatcg
     6781 gcctgttttt cggtctggct gaactttggg ccggacggat gcgttttgtg gggctgagtc
     6841 ataaggagcg acgggagtat gccgatcgct ataagcgcga taataaacgg ccagcgccat
     6901 tttcggtgct ggcctcgctg gattcgcccg ggcggatggt cagggcacgt cgacatgtct
     6961 ggaactacgc gtactggctg accggcgcgg ccggtctggc ccttctgggg gggctggttg
     7021 tcgccgtgtt tatcgagagc tggggagaaa ccgtcctgcg tccggacctc tacgcaaacg
     7081 cagattatta cctgctgcag ccggctaacc tgttcgggat tgcctggtgc gcgggcgggc
     7141 tggctgtcgg gattgtgttg gcgcggctgc tggcgttcct gctgcttgac ggtcattttg
     7201 cggctgctga cgaggcggtg aacgcgaaac tgaatcagga gagccggcgc agcagccagc
     7261 ggacaggaga gatgaccgac gtgcgccacc tgcatttcgg ggagccggta ccggttaatg
     7321 cgctggccga tttttcctcg gagcaggccc ggcaggagca ggcggtgttt ctgggtaagg
     7381 atgagcaggg caagccggtg ctggttccgc gtgatacctg gcgcaagacc aacattcaga
     7441 tcctcggcct gcccgggagc ggcaagagcg tgatggccac caacgcgctc attcgctgcg
     7501 tacgcgattt cggggacgcg gtggtgtact tcgaccccaa aggggacgca tgggcgccgc
     7561 acgtcttccg ggcgcactgt ccggacttca ccctgctgga tctgcggccg gggaaaccgg
     7621 cgcagctgaa tctgttccgc gatctcgacc agtacgcgct gaaaaacctg ctgattgccg
     7681 ggcttaacct gggcgagacc ggcgacgtgg cggaccacta ccgcatcagc gagcagaaag
     7741 cggcgaagct gattgcggag cagtttccgc agggggcaaa cattcagcag gtgctggcgg
     7801 cggcgtacgc gctgccggag gccctgaaaa aggacgtgaa ggggttgatc actaggctgg
     7861 aaaacgtcgc tgacctgagc gtcctgcaga cggacagtgg catcgatgtg gcggggatta
     7921 tcaacggcgg cggctgcctg tacgttatcg gctcgatgga cgacgaggcg gtgatccgtg
     7981 tgcaaaaaat gctgtttgcc cgctgcgcgc aaatcatcat tgcgcgggac gagttccggg
     8041 agtggccaca cgtcagcgtg atgctcgatg aaattaaata tctgctgtcg aagtatgtac
     8101 tgaacgcact ggggacgctg cgcagccggg actgcaatct gttgctcgcg caccagtcgc
     8161 tgggcgattt cgggcagtgc gggcaggatc tgcccgctga atttgtgaaa accacggtac
     8221 tggataacac gccgatccgc tggttttacc gggcggccag cctggagtcc gcgcagtggg
     8281 cggcggggca gaccggggaa atcagggtgg acgtggagcg ccgccgtgcc agccgggagg
     8341 cggggaacgt ggagcatatc agcggggaca gcttcatcca gaaggaggcg cggccgctgt
     8401 ttgacgtgaa caccctgcaa cacctgccgg acgggttcgc ggtcatgacc gggctgggtg
     8461 tggcccggat ggcgttcagc agtccgctgc gggttgagcg ccgggaaatc ccgttgcagc
     8521 gtttcccggt gctggcgaaa accgatcccc tggcggagtt ccggcccccg gccgacggcg
     8581 gcgggccgaa agcggatgat gattttgcgg ggatttactg atggcgctgg agctgtacaa
     8641 cgtcagccac gcgaaacgac aggcgcggaa cgcggagaaa acccggctga ccctgcgctg
     8701 gttgcgggaa gagctgtgtt ccacggcgga gctggttgcg cggcggctgg ggattgcggc
     8761 ggtgcagccg gtctaccgct tcctcgacag cctggtggcg aaagggctgc tggtccggac
     8821 caaatatccg gtggacggcc gtcaggtcag cgtgtggggg ctgacgccgc atggcgtggc
     8881 gttctcgttc gacgaggacg aaccgctggc ggatgttatt ccgtttcagc cgtcaagggt
     8941 gtcggcagca catctgccgc accggctggc cgtgcaatcc ctgcgccttg atatggaagc
     9001 cagaggggcc accggctggc gcattctgca ccgtctgagt cttaaaggca tgaaagtgcc
     9061 ggacgccctg gcggagctgg acggtaaaac ggtggcgttt gaggtggagc gcaccgtcaa
     9121 gagccgtcgc cggtatcagg aagtggtgtc cgggtatctg ttcaaccgca aagctaacgg
     9181 catcgatgaa atctggtaca tctgcccgga ccgggcgacg caggtcaggg tgcagcgggc
     9241 aatcctgtcg gtggatgaaa tcgtgaaccc acagaccggc gaggcccgca aaac
//
