LOCUS       CP052481                9294 bp    DNA     circular BCT 04-MAY-2020
DEFINITION  Klebsiella pneumoniae strain C16KP0050 plasmid pC16KP0050-5,
            complete sequence.
ACCESSION   CP052481
VERSION     CP052481.1
DBLINK      BioProject: PRJNA625837
            BioSample: SAMN14609883
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 9294)
  AUTHORS   Yoon,E.-J., Gwon,B., Liu,C., Kim,D., Won,D., Park,S.G., Choi,J.R.
            and Jeong,S.H.
  TITLE     Built-in CTX-M extended-spectrum beta-lactamase gene in Klebsiella
            pneumoniae ensuring stable propagation of the multidrug-resistant
            pathogen in clinical settings
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9294)
  AUTHORS   Yoon,E.-J., Gwon,B., Liu,C., Kim,D., Won,D., Park,S.G., Choi,J.R.
            and Jeong,S.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-APR-2020) Research Institute of Bacterial Resistance,
            Yonsei University College of Medicine, 211, Eonjuro, Gangnam-Gu,
            Seoul 06273, Korea, Republic of
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: Oxford Nanopore and Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/27/2020 20:57:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 5,764
            CDSs (total)                      :: 5,637
            Genes (coding)                    :: 5,505
            CDSs (with protein)               :: 5,505
            Genes (RNA)                       :: 127
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 89
            ncRNAs                            :: 13
            Pseudo Genes (total)              :: 132
            CDSs (without protein)            :: 132
            Pseudo Genes (ambiguous residues) :: 0 of 132
            Pseudo Genes (frameshifted)       :: 69 of 132
            Pseudo Genes (incomplete)         :: 66 of 132
            Pseudo Genes (internal stop)      :: 18 of 132
            Pseudo Genes (multiple problems)  :: 20 of 132
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..9294
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="C16KP0050"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="pC16KP0050-5"
                     /geo_loc_name="South Korea: Gangwon"
                     /lat_lon="37.82 N 128.16 E"
                     /collection_date="2016"
                     /collected_by="Kor-GLASS"
     gene            join(9034..9294,1..159)
                     /gene="exc2"
                     /locus_tag="HJW95_28695"
     CDS             join(9034..9294,1..159)
                     /gene="exc2"
                     /locus_tag="HJW95_28695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /protein_id="QJL75418.1"
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
                     /name="exc2"
     gene            465..728
                     /locus_tag="HJW95_28700"
     CDS             465..728
                     /locus_tag="HJW95_28700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid stabilization protein"
                     /protein_id="QJL75419.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="plasmid stabilization protein"
     gene            718..1017
                     /locus_tag="HJW95_28705"
     CDS             718..1017
                     /locus_tag="HJW95_28705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="QJL75420.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(1079..1456)
                     /locus_tag="HJW95_28710"
     CDS             complement(1079..1456)
                     /locus_tag="HJW95_28710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="entry exclusion protein 1"
                     /protein_id="QJL75421.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="entry exclusion protein 1"
     gene            1525..1704
                     /locus_tag="HJW95_28715"
     CDS             1525..1704
                     /locus_tag="HJW95_28715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="QJL75422.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(1732..2262)
                     /locus_tag="HJW95_28720"
     CDS             complement(1732..2262)
                     /locus_tag="HJW95_28720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QJL75423.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(2269..3000)
                     /locus_tag="HJW95_28725"
     CDS             complement(2269..3000)
                     /locus_tag="HJW95_28725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication-relaxation family protein"
                     /protein_id="QJL75424.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="replication-relaxation family protein"
     gene            complement(3000..4964)
                     /locus_tag="HJW95_28730"
     CDS             complement(3000..4964)
                     /locus_tag="HJW95_28730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="QJL75425.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     gene            complement(6445..6594)
                     /locus_tag="HJW95_28735"
     CDS             complement(6445..6594)
                     /locus_tag="HJW95_28735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="QJL75426.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            complement(6679..6936)
                     /locus_tag="HJW95_28740"
     CDS             complement(6679..6936)
                     /locus_tag="HJW95_28740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="QJL75427.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin"
     gene            complement(6946..8631)
                     /locus_tag="HJW95_28745"
     CDS             complement(6946..8631)
                     /locus_tag="HJW95_28745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="QJL75428.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="cloacin"
     BGC             1946..9294
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          5764..6342
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(2273..3000)
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.32e-150"
ORIGIN
        1 cagcagtttc acagtcagga atttttaaac tcactccaag gcacaacaca atttgcgggt
       61 accgattacc gcagcaaaga cctcacaccg aaaaaatcaa ggctactggc tgacaccatt
      121 tcagctgttt atctcgatgg ctatgaaggc agacagtaag tggatttacc ataacgcgtc
      181 attacgcgca ccgctcagac gggctcaggg cgtttccggc ggctacggga taaaacaggc
      241 aacaaccccc ccggaaaact gccggaaacg cgcccgataa attttatcct aatgcatgcc
      301 tatgcacgca actgcatggc atatgttttg acgtaaaatg gatgccgtaa gccctttttt
      361 accgactttc tgcttcatca gcctgactga cacgaccata ttctttcaga ccgccccctg
      421 ctaaacttcc ttcatattgc cgcattaacc cgggaggctc cgcaatgagc aacactacac
      481 actacgaaaa cgccaacttt cttcgggaac tggctgaaag cctgccccgc atactgccgg
      541 aaggtggccc ggacaaagct gcgctgttgc agcgactggc taacgaagaa ctggcccagg
      601 cagagtatga agatcaggtt cgcgccaaag tgaccgccgc ccgtgctgac acgcgtccgg
      661 gtatgaccac ggaacaactc cgccagcgcc tgcatggccg ttatcaggaa ctgcgcgatg
      721 ccgtatgacg tggaatggaa gcagggagcc atcgaggatg taacgacgct gtttgactat
      781 atcgcggaaa attcatccct gtgggatgcg cagaacgtta ccgaccgggt tctcgctgcg
      841 gcggacaaac tggccgactt cccgcgactc tatgaagtgg actcacgcta tggcgaggac
      901 gttcgccgga tcagtctgat gggacagcat gtcctctatg atgttgatga ccagaccaga
      961 aaagtccggg ttctggccgt ggtcggccag cgccagaatc cccatattgt tctctaataa
     1021 ccggtgacgg ggacgcaatt cattgcgtgg ccgtcgccgg ttggacaagc acagcgcgtc
     1081 agcgttttcc ccacggccac caccggcgcg gtgttccggc cggggtctct gctgtctccg
     1141 gtttgtgttc cagcagtctc atggactgca tttcctgccg tagcccggcc acctcctccc
     1201 tgagtgcttt tatctccgcg atcaacgcgt cggaggccat tttttcagtc tcacccgaca
     1261 gtctcaactc gtcccgctcg tgagtctcat cctgtcttaa ctcaccgtac acccggataa
     1321 gctcgctggt atccaccacc cggccgccat cagcttccgt acggtatgat acgcggcctt
     1381 tcgccatatc ccgatacagg gaacttcggg ctttacccgt cagttccgtc gcctgtctca
     1441 ccgtcaccca cgccattgtc tcaccccgct atttttgaga cagtatacct gacaggcgca
     1501 caccatgccc ggaaggaaag aatcatgaca aaacaggaaa aaacagccct caatatggct
     1561 aaatttatta aggagcagtc gctgctattg ctcgataaac tgaatgagct ggatatggat
     1621 accccggccg acatgtgcga gcggctacac gaggatgcgg aaacactctg gcaggtgatg
     1681 cgggataagc tcggggagga ataacagcac cggcatggcc ggtgctggca tttatttttt
     1741 gccgaacggc caccaccggc gggcaggttt gtcctccggc agttcaggta ccggcacgtt
     1801 aaaatagcgg ctgttatatt cccgcatcag ctccgctttc agcttctcgt tcaccgcgct
     1861 ttccccgtgc cgctcactca ccacgtcaat catcgcgtta atctgctccg gtgagcactt
     1921 cccggcatca accacctgca caccgttctc gatggcgaac cgctccacct tgcgatagag
     1981 gtaatcacac agcttcattc ctgtgggttt gttccgttcc cattgcggat ttttaccagt
     2041 gaaaaagtac gtggcttttt cgtcgctgtt gagccgctcg tcatacatcc cgatggattt
     2101 catcatcgcc agatgctggg cccggtcgac aaaacagaaa acatacgccc cggtctgcca
     2161 ggcgagcacc accatatctt ccagatgctc gctggtcggc atgatgcagc gctcgccgtt
     2221 ccggtcctcc gcgtcttcaa taaataccat gtacagcgcc ataatccctc actccgttgt
     2281 cataaattta aagcacgcaa acaaccgttc acgatccagc tctgccgttt tgcgggcctc
     2341 gccggtctgt gggttcacga tttcatccac cgacaggatt gcccgctgca ccctgacctg
     2401 cgtcgcccgg tccgggcaga tgtaccagat ttcatcgatg ccgttagctt tgcggttgaa
     2461 cagatacccg gacaccactt cctgataccg gcgacggctc ttgacggtgc gctccacctc
     2521 aaacgccacc gttttaccgt ccagctccgc cagggcgtcc ggcactttca tgcctttaag
     2581 actcagacgg tgcagaatgc gccagccggt ggcccctctg gcttccatat caaggcgcag
     2641 ggattgcacg gccagccggt gcggcagatg tgctgccgac acccttgacg gctgaaacgg
     2701 aataacatcc gccagcggtt cgtcctcgtc gaacgagaac gccacgccat gcggcgtcag
     2761 cccccacacg ctgacctgac ggccgtccac cggatatttg gtccggacca gcagcccttt
     2821 cgccaccagg ctgtcgagga agcggtagac cggctgcacc gccgcaatcc ccagccgccg
     2881 cgcaaccagc tccgccgtgg aacacagctc ttcccgcaac cagcgcaggg tcagccgggt
     2941 tttctccgcg ttccgcgcct gtcgtttcgc gtggctgacg ttgtacagct ccagcgccat
     3001 cagtaaatcc ccgcaaaatc atcatccgct ttcggcccgc cgccgtcggc cgggggccgg
     3061 aactccgcca ggggatcggt tttcgccagc accgggaaac gctgcaacgg gatttcccgg
     3121 cgctcaaccc gcagcggact gctgaacgcc atccgggcca cacccagccc ggtcatgacc
     3181 gcgaacccgt ccggcaggtg ttgcagggtg ttcacgtcaa acagcggccg cgcctccttc
     3241 tggatgaagc tgtccccgct gatatgctcc acgttccccg cctcccggct ggcacggcgg
     3301 cgctccacgt ccaccctgat ttccccggtc tgccccgccg cccactgcgc ggactccagg
     3361 ctggccgccc ggtaaaacca gcggatcggc gtgttatcca gtaccgtggt tttcacaaat
     3421 tcagcgggca gatcctgccc gcactgcccg aaatcgccca gcgactggtg cgcgagcaac
     3481 agattgcagt cccggctgcg cagcgtcccc agtgcgttca gtacatactt cgacagcaga
     3541 tatttaattt catcgagcat cacgctgacg tgtggccact cccggaactc gtcccgcgca
     3601 atgatgattt gcgcgcagcg ggcaaacagc attttttgca cacggatcac cgcctcgtcg
     3661 tccatcgagc cgataacgta caggcagccg ccgccgttga taatccccgc cacatcgatg
     3721 ccactgtccg tctgcaggac gctcaggtca gcgacgtttt ccagcctagt gatcaacccc
     3781 ttcacgtcct ttttcagggc ctccggcagc gcgtacgccg ccgccagcac ctgctgaatg
     3841 tttgccccct gcggaaactg ctccgcaatc agcttcgccg ctttctgctc gctgatgcgg
     3901 tagtggtccg ccacgtcgcc ggtctcgccc aggttaagcc cggcaatcag caggtttttc
     3961 agcgcgtact ggtcgagatc gcggaacaga ttcagctgcg ccggtttccc cggccgcaga
     4021 tccagcaggg tgaagtccgg acagtgcgcc cggaagacgt gcggcgccca tgcgtcccct
     4081 ttggggtcga agtacaccac cgcgtccccg aaatcgcgta cgcagcgaat gagcgcgttg
     4141 gtggccatca cgctcttgcc gctcccgggc aggccgagga tctgaatgtt ggtcttgcgc
     4201 caggtatcac gcggaaccag caccggcttg ccctgctcat ccttacccag aaacaccgcc
     4261 tgctcctgcc gggcctgctc cgaggaaaaa tcggccagcg cattaaccgg taccggctcc
     4321 ccgaaatgca ggtggcgcac gtcggtcatc tctcctgtcc gctggctgct gcgccggctc
     4381 tcctgattca gtttcgcgtt caccgcctcg tcagcagccg caaaatgacc gtcaagcagc
     4441 aggaacgcca gcagccgcgc caacacaatc ccgacagcca gcccgcccgc gcaccaggca
     4501 atcccgaaca ggttagccgg ctgcagcagg taataatctg cgtttgcgta gaggtccgga
     4561 cgcaggacgg tttctcccca gctctcgata aacacggcga caaccagccc ccccagaagg
     4621 gccagaccgg ccgcgccggt cagccagtac gcgtagttcc agacatgtcg acgtgccctg
     4681 accatccgcc cgggcgaatc cagcgaggcc agcaccgaaa atggcgctgg ccgtttatta
     4741 tcgcgcttat agcgatcggc atactcccgt cgctccttat gactcagccc cacaaaacgc
     4801 atccgtccgg cccaaagttc agccagaccg aaaaacaggc cgataactag gaaagccccg
     4861 gccagaccgt aatactcctg gtacagccag ctgacccacg gataaatctg ccgggccagc
     4921 tccggaatgt gccacttcca ggcaagcgaa tccgtattaa acatgttctc tctccttcag
     4981 acgatggttt gccggcgtga tgtgcagccc ccgctgcaca agccgcggac atgccccaag
     5041 gcatggcggc ggcggtcacg tccgtggtga ttgcgttcag ctttcaccac ggaggccagc
     5101 ctctttccgc cccatgcgga aaaggcgcag ccccggagga acaacgagca cgccccagcg
     5161 tgtgagagga aaaggcggca ccccagtgcg gtcttttccg gtgttccggc ccccgtcaga
     5221 gttcgccata gcgagcggct gaccacccgc aaaatcagga gcagctttgc tgcttcgcca
     5281 ggtgcgtcca gcaccgtgga tttttgtggg tggtcaggcg tgagcctgac gggggccggg
     5341 tgaatttctg gcgtggccgg cgtccagccg gacggagcca gaaagagggg gagagaccgt
     5401 gcgtcggtgg cgtccagcca gcgtaagcag gggatatccc cctgaggtca gccacgccct
     5461 cgcggggatg acctgtattt ctccgtaagg agaaaaaagc aacagagata ggttaacgta
     5521 aaatgttcag cgaaaaaccg atatgattca cctatcctgg taatttatta tcagggaata
     5581 taaagactta atcaggggac aatatgccac atcagcgcgt ccggtgtccg tcttgtaggt
     5641 gccggggaaa ttgcgcctcc tcgctcactc ggtcgctacg ctccggccgt gagactgcgg
     5701 cgggcgctgc ggacacatgc aaagttaccc acagattccg tgaataagca ggggactaac
     5761 atgtgaggca aaacggcaag gccacgcagg tggcgttttt ccataggctc cgccctcctg
     5821 actgagttca cataaacaga cgctttttcg gtgcatctgt gggagccggt ggctcaacca
     5881 tgaatcagtc aggagtggcg aaacccgaca ggacttaaag atcatcaccg tttccgatga
     5941 atcgctccct cttgcgctct cctgttccaa ccctgccgtt tcccggatac ctgttccgcc
     6001 tttctccctt gcgggaagtg tggcgctttc tcatagctca cactctggta tctcggctcg
     6061 gtgtaggtcg ttcgctccaa gctgggctgt aagcaagaac cccccgttca gcccgactgc
     6121 tgcgccttat ccggtaactg ttcacttgag tccaacccgg aaaagcacgc aaaacgccac
     6181 tggcagcagc cattggtaac tgggagttcg cagaggattt gtttagctaa acacgcggtt
     6241 gctcttgaag tgtgcgccaa agtccggcta cactggaagg acagatttgg ttgctgtgct
     6301 ctgcgaaagc cagttaccac ggttaagcag ttccccaact gacttaacct tcgatcaaac
     6361 cacctcccca ggtggttttt tcgtttacag ggcaaaagat tacgcgcaga aaaaaaggat
     6421 ctcaagaaga tcctttgatc ttttctactg aaccgcgatc cccgtcagtt cagaggagga
     6481 cgatggtgcc accgttccac cctgaacatc ccggatatag tttgcctgac atgcgaccag
     6541 aagaaagcct gaaaaaatca atataaaaag aaaaacaacc tttacctttt tcatatacct
     6601 tccctgtatt taaaaacccc ggtattcatc cctgaacacc ggaagtctgt atttcaaatc
     6661 atccttgata acttttgctt accagttacc atcccggtaa acaaaggata caaagtaatc
     6721 aaatttacta atatcgatta catttttaaa gtgtggctgt aatatcgaaa cccatgattt
     6781 ttcaacatca aaccaaccat tattaatatt atcctttaaa ggcatcccca gactttcaat
     6841 gacagaacca tcatcaccga agtcttttga gtattcacca cctttaaact cttcggtttt
     6901 cttatcaaac caatgaatat gtaatttaag ccccatattt acctcttaaa gatatttttt
     6961 aatgtttcgt tttggatccg gccctttaac ctgcttaccc gtttttggat cgaatgcccc
     7021 gaggtgttcg ccatcactgg cgcggtaccc ttcaagctca ccgtgctggg aatcccattc
     7081 ataaatttta cgctttttat caccatacca tcgggcccgc ttaccaccac caccttgttt
     7141 aggggtttta ggtttaccct ctttcaactc tcccaacccc ttaatatctt cagtcttggg
     7201 atcaggaaaa taatcatggc cgtaatcttt agttccctta cgaggttttt tcttttcctc
     7261 atttaattta ttttctgcat ccttcgcttt tttctccttt tgtttccggc tctccatcgc
     7321 cccggaaagc gcagccttat ccctggataa ggattcattc atttcgttta aagatgtctg
     7381 ggcagctttt aatttctcat tctgattctg aatatcctta tcaagatagc gaacctgatc
     7441 ctgccacccg gagccatatt catgaggcgg gttataagtc acaaaatcat ctttatttgc
     7501 ctctgcctct tttacctttt tatcggcttc ctgaacagca gcccttgcac cggggatcgc
     7561 cttctctgtc gatgcaatgc gactgtttaa ggtcgcaata tttttatctt cagcatccag
     7621 ctcagctttc gctttatcat actctctttt cagcccctct tccgggtgag cagcgtccca
     7681 tgcctgctgg cgacgctttt cttcctccag acgctgtttt acctgtgccg gagtaagaac
     7741 atccgtcacc gacacataga ccggtttctg tccgctctct ttcgggaaac gaataacggc
     7801 ttcacgggag ttaccaccgg ccgtaaaacc agccggacgt gaatcacctt tttcagcaat
     7861 aatgcctttt ggcggggctt tcgcggccgg aacaccttta ggtacgctca cctgcagaga
     7921 cgggagaccc ggaatcgaca cactgaatac ccccggacgt tttgtcggtt tcgcatccac
     7981 cacaggaaca ctcattggcc ggccggtgac aaccgcaata tgctgccgct cgtccttcac
     8041 aatatccgcc acacgtttag tgacgctgac cgtcgcctgg tccagcggca gggagctgac
     8101 cggcgtctcc gttaccgtgt ctgccggcaa tgacgtcacg atttttgaca tcattttcgg
     8161 atcatctttt gctatctcag aaggcagcac tccgtaaatc gcaatccccc acagaccaaa
     8221 cttaaacgga cctttcaggg cagccagcac atcagcaaca gcggccgaca acgcatcgcc
     8281 ggaaacggat aaagccagtc cttcagcccc cggagtggcc aaggcaggca gaccgaaggc
     8341 catcgcggtg gccgaagact gtccgccacc agagctcccg ctatgattgc cgctgttacc
     8401 gccattacca ccgggtttac tcccgccgtt accaaactcc cccgggttat agttatgaat
     8461 atccccgtta ggtgtatgcg tcgtacccca gcccggcccg ctgtttggat ccgtaccacc
     8521 acctgatgaa gggccacctt tacctgatgt accgttcaca ttcccactgg cctgaccacc
     8581 attgtgtccc agacctgaat tacccggacc tcgtccgtct ccgccactca tatacttttc
     8641 ctctttgact tttaaaacaa taaactaaaa taaaatactg tacatataac cacttgtttt
     8701 atatacagta taaaaattac gctgccttgt ttttcatgtc aagtctgtaa atttgcgttt
     8761 ttgtgaaaat gatcaaaaaa acagccactc acaccatgcg caatcccctc cagatgcaac
     8821 aaaaaccagc acaaacggcg ccgttctccg gcctcagtat gttttactga aatcattata
     8881 tgagatacca gaaagccccc tccgggacag gaaaagaaac ggggggtctg gttcgggttg
     8941 ttcggtcact gaacacggtc agaaactgat gataagatag cctgcggata tataactcaa
     9001 tgagaaaaaa gaattaaagg taaggagacg ctcatgagac gttccggcag caaactgtgt
     9061 cttatcgcca tgataacagc gacagcaact ctcactgcct gtgctccaaa gggcagcgtg
     9121 gaacagcata cccggcatta cgtatatgct tcagatgacg gttttgatcc caatttttcc
     9181 acccagaaag ctgacacaac acgaatgatg gtgccttttt tccggcagtt ctgggatatg
     9241 ggcgcaaagg ataaagcgac cggaaaatca cggagtgatg tgcagcaacg catt
//
