LOCUS       CP052439                9294 bp    DNA     circular BCT 04-MAY-2020
DEFINITION  Klebsiella pneumoniae strain C16KP0108 plasmid pC16KP0108-5,
            complete sequence.
ACCESSION   CP052439
VERSION     CP052439.1
DBLINK      BioProject: PRJNA625837
            BioSample: SAMN14609890
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 9294)
  AUTHORS   Yoon,E.-J., Gwon,B., Liu,C., Kim,D., Won,D., Park,S.G., Choi,J.R.
            and Jeong,S.H.
  TITLE     Built-in CTX-M extended-spectrum beta-lactamase gene in Klebsiella
            pneumoniae ensuring stable propagation of the multidrug-resistant
            pathogen in clinical settings
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9294)
  AUTHORS   Yoon,E.-J., Gwon,B., Liu,C., Kim,D., Won,D., Park,S.G., Choi,J.R.
            and Jeong,S.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-APR-2020) Research Institute of Bacterial Resistance,
            Yonsei University College of Medicine, 211, Eonjuro, Gangnam-Gu,
            Seoul 06273, Korea, Republic of
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: Oxford Nanopore and Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/27/2020 21:17:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 5,934
            CDSs (total)                      :: 5,813
            Genes (coding)                    :: 5,675
            CDSs (with protein)               :: 5,675
            Genes (RNA)                       :: 121
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 10
            Pseudo Genes (total)              :: 138
            CDSs (without protein)            :: 138
            Pseudo Genes (ambiguous residues) :: 0 of 138
            Pseudo Genes (frameshifted)       :: 68 of 138
            Pseudo Genes (incomplete)         :: 69 of 138
            Pseudo Genes (internal stop)      :: 27 of 138
            Pseudo Genes (multiple problems)  :: 26 of 138
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..9294
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="C16KP0108"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="pC16KP0108-5"
                     /geo_loc_name="South Korea: Gangwon"
                     /lat_lon="37.82 N 128.16 E"
                     /collection_date="2016"
                     /collected_by="Kor-GLASS"
     gene            join(9139..9294,1..1809)
                     /locus_tag="HJX02_29620"
     CDS             join(9139..9294,1..1809)
                     /locus_tag="HJX02_29620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="QJL48411.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     gene            1809..2540
                     /locus_tag="HJX02_29625"
     CDS             1809..2540
                     /locus_tag="HJX02_29625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication-relaxation family protein"
                     /protein_id="QJL48412.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="replication-relaxation family protein"
     gene            2547..3077
                     /locus_tag="HJX02_29630"
     CDS             2547..3077
                     /locus_tag="HJX02_29630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QJL48413.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(3105..3284)
                     /locus_tag="HJX02_29635"
     CDS             complement(3105..3284)
                     /locus_tag="HJX02_29635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="QJL48414.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            3353..3730
                     /locus_tag="HJX02_29640"
     CDS             3353..3730
                     /locus_tag="HJX02_29640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="entry exclusion protein 1"
                     /protein_id="QJL48415.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="entry exclusion protein 1"
     gene            complement(3792..4091)
                     /locus_tag="HJX02_29645"
     CDS             complement(3792..4091)
                     /locus_tag="HJX02_29645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="QJL48416.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(4081..4344)
                     /locus_tag="HJX02_29650"
     CDS             complement(4081..4344)
                     /locus_tag="HJX02_29650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid stabilization protein"
                     /protein_id="QJL48417.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="plasmid stabilization protein"
     gene            complement(4650..5069)
                     /gene="exc2"
                     /locus_tag="HJX02_29655"
     CDS             complement(4650..5069)
                     /gene="exc2"
                     /locus_tag="HJX02_29655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /protein_id="QJL48418.1"
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
                     /name="exc2"
     gene            5472..7157
                     /locus_tag="HJX02_29660"
     CDS             5472..7157
                     /locus_tag="HJX02_29660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="QJL48419.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="cloacin"
     gene            7167..7424
                     /locus_tag="HJX02_29665"
     CDS             7167..7424
                     /locus_tag="HJX02_29665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="QJL48420.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin"
     gene            7509..7658
                     /locus_tag="HJX02_29670"
     CDS             7509..7658
                     /locus_tag="HJX02_29670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="QJL48421.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     BGC             472..9294
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          complement(7762..8340)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          1810..2537
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.32e-150"
ORIGIN
        1 ggacggatgc gttttgtggg gctgagtcat aaggagcgac gggagtatgc cgatcgctat
       61 aagcgcgata ataaacggcc agcgccattt tcggtgctgg cctcgctgga ttcgcccggg
      121 cggatggtca gggcacgtcg acatgtctgg aactacgcgt actggctgac cggcgcggcc
      181 ggtctggccc ttctgggggg gctggttgtc gccgtgttta tcgagagctg gggagaaacc
      241 gtcctgcgtc cggacctcta cgcaaacgca gattattacc tgctgcagcc ggctaacctg
      301 ttcgggattg cctggtgcgc gggcgggctg gctgtcggga ttgtgttggc gcggctgctg
      361 gcgttcctgc tgcttgacgg tcattttgcg gctgctgacg aggcggtgaa cgcgaaactg
      421 aatcaggaga gccggcgcag cagccagcgg acaggagaga tgaccgacgt gcgccacctg
      481 catttcgggg agccggtacc ggttaatgcg ctggccgatt tttcctcgga gcaggcccgg
      541 caggagcagg cggtgtttct gggtaaggat gagcagggca agccggtgct ggttccgcgt
      601 gatacctggc gcaagaccaa cattcagatc ctcggcctgc ccgggagcgg caagagcgtg
      661 atggccacca acgcgctcat tcgctgcgta cgcgatttcg gggacgcggt ggtgtacttc
      721 gaccccaaag gggacgcatg ggcgccgcac gtcttccggg cgcactgtcc ggacttcacc
      781 ctgctggatc tgcggccggg gaaaccggcg cagctgaatc tgttccgcga tctcgaccag
      841 tacgcgctga aaaacctgct gattgccggg cttaacctgg gcgagaccgg cgacgtggcg
      901 gaccactacc gcatcagcga gcagaaagcg gcgaagctga ttgcggagca gtttccgcag
      961 ggggcaaaca ttcagcaggt gctggcggcg gcgtacgcgc tgccggaggc cctgaaaaag
     1021 gacgtgaagg ggttgatcac taggctggaa aacgtcgctg acctgagcgt cctgcagacg
     1081 gacagtggca tcgatgtggc ggggattatc aacggcggcg gctgcctgta cgttatcggc
     1141 tcgatggacg acgaggcggt gatccgtgtg caaaaaatgc tgtttgcccg ctgcgcgcaa
     1201 atcatcattg cgcgggacga gttccgggag tggccacacg tcagcgtgat gctcgatgaa
     1261 attaaatatc tgctgtcgaa gtatgtactg aacgcactgg ggacgctgcg cagccgggac
     1321 tgcaatctgt tgctcgcgca ccagtcgctg ggcgatttcg ggcagtgcgg gcaggatctg
     1381 cccgctgaat ttgtgaaaac cacggtactg gataacacgc cgatccgctg gttttaccgg
     1441 gcggccagcc tggagtccgc gcagtgggcg gcggggcaga ccggggaaat cagggtggac
     1501 gtggagcgcc gccgtgccag ccgggaggcg gggaacgtgg agcatatcag cggggacagc
     1561 ttcatccaga aggaggcgcg gccgctgttt gacgtgaaca ccctgcaaca cctgccggac
     1621 gggttcgcgg tcatgaccgg gctgggtgtg gcccggatgg cgttcagcag tccgctgcgg
     1681 gttgagcgcc gggaaatccc gttgcagcgt ttcccggtgc tggcgaaaac cgatcccctg
     1741 gcggagttcc ggcccccggc cgacggcggc gggccgaaag cggatgatga ttttgcgggg
     1801 atttactgat ggcgctggag ctgtacaacg tcagccacgc gaaacgacag gcgcggaacg
     1861 cggagaaaac ccggctgacc ctgcgctggt tgcgggaaga gctgtgttcc acggcggagc
     1921 tggttgcgcg gcggctgggg attgcggcgg tgcagccggt ctaccgcttc ctcgacagcc
     1981 tggtggcgaa agggctgctg gtccggacca aatatccggt ggacggccgt caggtcagcg
     2041 tgtgggggct gacgccgcat ggcgtggcgt tctcgttcga cgaggacgaa ccgctggcgg
     2101 atgttattcc gtttcagccg tcaagggtgt cggcagcaca tctgccgcac cggctggccg
     2161 tgcaatccct gcgccttgat atggaagcca gaggggccac cggctggcgc attctgcacc
     2221 gtctgagtct taaaggcatg aaagtgccgg acgccctggc ggagctggac ggtaaaacgg
     2281 tggcgtttga ggtggagcgc accgtcaaga gccgtcgccg gtatcaggaa gtggtgtccg
     2341 ggtatctgtt caaccgcaaa gctaacggca tcgatgaaat ctggtacatc tgcccggacc
     2401 gggcgacgca ggtcagggtg cagcgggcaa tcctgtcggt ggatgaaatc gtgaacccac
     2461 agaccggcga ggcccgcaaa acggcagagc tggatcgtga acggttgttt gcgtgcttta
     2521 aatttatgac aacggagtga gggattatgg cgctgtacat ggtatttatt gaagacgcgg
     2581 aggaccggaa cggcgagcgc tgcatcatgc cgaccagcga gcatctggaa gatatggtgg
     2641 tgctcgcctg gcagaccggg gcgtatgttt tctgttttgt cgaccgggcc cagcatctgg
     2701 cgatgatgaa atccatcggg atgtatgacg agcggctcaa cagcgacgaa aaagccacgt
     2761 actttttcac tggtaaaaat ccgcaatggg aacggaacaa acccacagga atgaagctgt
     2821 gtgattacct ctatcgcaag gtggagcggt tcgccatcga gaacggtgtg caggtggttg
     2881 atgccgggaa gtgctcaccg gagcagatta acgcgatgat tgacgtggtg agtgagcggc
     2941 acggggaaag cgcggtgaac gagaagctga aagcggagct gatgcgggaa tataacagcc
     3001 gctattttaa cgtgccggta cctgaactgc cggaggacaa acctgcccgc cggtggtggc
     3061 cgttcggcaa aaaataaatg ccagcaccgg ccatgccggt gctgttattc ctccccgagc
     3121 ttatcccgca tcacctgcca gagtgtttcc gcatcctcgt gtagccgctc gcacatgtcg
     3181 gccggggtat ccatatccag ctcattcagt ttatcgagca atagcagcga ctgctcctta
     3241 ataaatttag ccatattgag ggctgttttt tcctgttttg tcatgattct ttccttccgg
     3301 gcatggtgtg cgcctgtcag gtatactgtc tcaaaaatag cggggtgaga caatggcgtg
     3361 ggtgacggtg agacaggcga cggaactgac gggtaaagcc cgaagttccc tgtatcggga
     3421 tatggcgaaa ggccgcgtat cataccgtac ggaagctgat ggcggccggg tggtggatac
     3481 cagcgagctt atccgggtgt acggtgagtt aagacaggat gagactcacg agcgggacga
     3541 gttgagactg tcgggtgaga ctgaaaaaat ggcctccgac gcgttgatcg cggagataaa
     3601 agcactcagg gaggaggtgg ccgggctacg gcaggaaatg cagtccatga gactgctgga
     3661 acacaaaccg gagacagcag agaccccggc cggaacaccg cgccggtggt ggccgtgggg
     3721 aaaacgctga cgcgctgtgc ttgtccaacc ggcgacggcc acgcaatgaa ttgcgtcccc
     3781 gtcaccggtt attagagaac aatatgggga ttctggcgct ggccgaccac ggccagaacc
     3841 cggacttttc tggtctggtc atcaacatca tagaggacat gctgtcccat cagactgatc
     3901 cggcgaacgt cctcgccata gcgtgagtcc acttcataga gtcgcgggaa gtcggccagt
     3961 ttgtccgccg cagcgagaac ccggtcggta acgttctgcg catcccacag ggatgaattt
     4021 tccgcgatat agtcaaacag cgtcgttaca tcctcgatgg ctccctgctt ccattccacg
     4081 tcatacggca tcgcgcagtt cctgataacg gccatgcagg cgctggcgga gttgttccgt
     4141 ggtcataccc ggacgcgtgt cagcacgggc ggcggtcact ttggcgcgaa cctgatcttc
     4201 atactctgcc tgggccagtt cttcgttagc cagtcgctgc aacagcgcag ctttgtccgg
     4261 gccaccttcc ggcagtatgc ggggcaggct ttcagccagt tcccgaagaa agttggcgtt
     4321 ttcgtagtgt gtagtgttgc tcattgcgga gcctcccggg ttaatgcggc aatatgaagg
     4381 aagtttagca gggggcggtc tgaaagaata tggtcgtgtc agtcaggctg atgaagcaga
     4441 aagtcggtaa aaaagggctt acggcatcca ttttacgtca aaacatatgc catgcagttg
     4501 cgtgcatagg catgcattag gataaaattt atcgggcgcg tttccggcag ttttccgggg
     4561 gggttgttgc ctgttttatc ccgtagccgc cggaaacgcc ctgagcccgt ctgagcggtg
     4621 cgcgtaatga cgcgttatgg taaatccact tactgtctgc cttcatagcc atcgagataa
     4681 acagctgaaa tggtgtcagc cagtagcctt gattttttcg gtgtgaggtc tttgctgcgg
     4741 taatcggtac ccgcaaattg tgttgtgcct tggagtgagt ttaaaaattc ctgactgtga
     4801 aactgctgaa tgcgttgctg cacatcactc cgtgattttc cggtcgcttt atcctttgcg
     4861 cccatatccc agaactgccg gaaaaaaggc accatcattc gtgttgtgtc agctttctgg
     4921 gtggaaaaat tgggatcaaa accgtcatct gaagcatata cgtaatgccg ggtatgctgt
     4981 tccacgctgc cctttggagc acaggcagtg agagttgctg tcgctgttat catggcgata
     5041 agacacagtt tgctgccgga acgtctcatg agcgtctcct tacctttaat tcttttttct
     5101 cattgagtta tatatccgca ggctatctta tcatcagttt ctgaccgtgt tcagtgaccg
     5161 aacaacccga accagacccc ccgtttcttt tcctgtcccg gagggggctt tctggtatct
     5221 catataatga tttcagtaaa acatactgag gccggagaac ggcgccgttt gtgctggttt
     5281 ttgttgcatc tggaggggat tgcgcatggt gtgagtggct gtttttttga tcattttcac
     5341 aaaaacgcaa atttacagac ttgacatgaa aaacaaggca gcgtaatttt tatactgtat
     5401 ataaaaccag tggttatatg tacagtattt tattttagtt tattgtttta aaagtcaaag
     5461 aggaaaagta tatgagtggc ggagacggac gaggtccggg taattcaggt ctgggacaca
     5521 atggtggtca ggccagtggg aatgtgaacg gtacatcagg taaaggtggc ccttcatcag
     5581 gtggtggtac ggatccaaac agcgggccgg gctggggtac gacgcataca cctaacgggg
     5641 atattcataa ctataacccg ggggagtttg gtaacggcgg gagtaaaccc ggtggtaatg
     5701 gcggtaacag cggcaatcat agcgggagct ctggtggcgg acagtcttcg gccaccgcga
     5761 tggccttcgg tctgcctgcc ctggccactc cgggggctga aggactggct ttatccgttt
     5821 ccggcgatgc gttgtcggcc gctgttgctg atgtgctggc tgccctgaaa ggtccgttta
     5881 agtttggtct gtgggggatt gcgatttacg gagtgctgcc ttctgagata gcaaaagatg
     5941 atccgaaaat gatgtcaaaa atcgtgacgt cattgccggc agacacggta acggagacgc
     6001 cggtcagctc cctgccgctg gaccaggcga cggtcagcgt cactaaacgt gtggcggata
     6061 ttgtgaagga cgagcggcag catattgcgg ttgtcaccgg ccggccaatg agtgttcctg
     6121 tggtggatgc gaaaccgaca aaacgtccgg gggtattcag tgtgtcgatt ccgggtctcc
     6181 cgtctctgca ggtgagcgta cctaaaggtg ttccggccgc gaaagccccg ccaaaaggca
     6241 ttattgctga aaaaggtgat tcacgtccgg ctggttttac ggccggtggt aactcccgtg
     6301 aggccgttat tcgtttcccg aaagagagcg gacagaaacc ggtctatgtg tcggtgacgg
     6361 atgttcttac tccggcacag gtaaaacagc gtctggagga agaaaagcgt cgccagcagg
     6421 catgggacgc tgctcacccg gaagaggggc tgaaaagaga gtatgataaa gcgaaagctg
     6481 agctggatgc tgaagataaa aatattgcga ccttaaacag tcgcattgca tcgacagaga
     6541 aggcgatccc cggtgcaagg gctgctgttc aggaagccga taaaaaggta aaagaggcag
     6601 aggcaaataa agatgatttt gtgacttata acccgcctca tgaatatggc tccgggtggc
     6661 aggatcaggt tcgctatctt gataaggata ttcagaatca gaatgagaaa ttaaaagctg
     6721 cccagacatc tttaaacgaa atgaatgaat ccttatccag ggataaggct gcgctttccg
     6781 gggcgatgga gagccggaaa caaaaggaga aaaaagcgaa ggatgcagaa aataaattaa
     6841 atgaggaaaa gaaaaaacct cgtaagggaa ctaaagatta cggccatgat tattttcctg
     6901 atcccaagac tgaagatatt aaggggttgg gagagttgaa agagggtaaa cctaaaaccc
     6961 ctaaacaagg tggtggtggt aagcgggccc gatggtatgg tgataaaaag cgtaaaattt
     7021 atgaatggga ttcccagcac ggtgagcttg aagggtaccg cgccagtgat ggcgaacacc
     7081 tcggggcatt cgatccaaaa acgggtaagc aggttaaagg gccggatcca aaacgaaaca
     7141 ttaaaaaata tctttaagag gtaaatatgg ggcttaaatt acatattcat tggtttgata
     7201 agaaaaccga agagtttaaa ggtggtgaat actcaaaaga cttcggtgat gatggttctg
     7261 tcattgaaag tctggggatg cctttaaagg ataatattaa taatggttgg tttgatgttg
     7321 aaaaatcatg ggtttcgata ttacagccac actttaaaaa tgtaatcgat attagtaaat
     7381 ttgattactt tgtatccttt gtttaccggg atggtaactg gtaagcaaaa gttatcaagg
     7441 atgatttgaa atacagactt ccggtgttca gggatgaata ccggggtttt taaatacagg
     7501 gaaggtatat gaaaaaggta aaggttgttt ttctttttat attgattttt tcaggctttc
     7561 ttctggtcgc atgtcaggca aactatatcc gggatgttca gggtggaacg gtggcaccat
     7621 cgtcctcctc tgaactgacg gggatcgcgg ttcagtagaa aagatcaaag gatcttcttg
     7681 agatcctttt tttctgcgcg taatcttttg ccctgtaaac gaaaaaacca cctggggagg
     7741 tggtttgatc gaaggttaag tcagttgggg aactgcttaa ccgtggtaac tggctttcgc
     7801 agagcacagc aaccaaatct gtccttccag tgtagccgga ctttggcgca cacttcaaga
     7861 gcaaccgcgt gtttagctaa acaaatcctc tgcgaactcc cagttaccaa tggctgctgc
     7921 cagtggcgtt ttgcgtgctt ttccgggttg gactcaagtg aacagttacc ggataaggcg
     7981 cagcagtcgg gctgaacggg gggttcttgc ttacagccca gcttggagcg aacgacctac
     8041 accgagccga gataccagag tgtgagctat gagaaagcgc cacacttccc gcaagggaga
     8101 aaggcggaac aggtatccgg gaaacggcag ggttggaaca ggagagcgca agagggagcg
     8161 attcatcgga aacggtgatg atctttaagt cctgtcgggt ttcgccactc ctgactgatt
     8221 catggttgag ccaccggctc ccacagatgc accgaaaaag cgtctgttta tgtgaactca
     8281 gtcaggaggg cggagcctat ggaaaaacgc cacctgcgtg gccttgccgt tttgcctcac
     8341 atgttagtcc cctgcttatt cacggaatct gtgggtaact ttgcatgtgt ccgcagcgcc
     8401 cgccgcagtc tcacggccgg agcgtagcga ccgagtgagc gaggaggcgc aatttccccg
     8461 gcacctacaa gacggacacc ggacgcgctg atgtggcata ttgtcccctg attaagtctt
     8521 tatattccct gataataaat taccaggata ggtgaatcat atcggttttt cgctgaacat
     8581 tttacgttaa cctatctctg ttgctttttt ctccttacgg agaaatacag gtcatccccg
     8641 cgagggcgtg gctgacctca gggggatatc ccctgcttac gctggctgga cgccaccgac
     8701 gcacggtctc tccccctctt tctggctccg tccggctgga cgccggccac gccagaaatt
     8761 cacccggccc ccgtcaggct cacgcctgac cacccacaaa aatccacggt gctggacgca
     8821 cctggcgaag cagcaaagct gctcctgatt ttgcgggtgg tcagccgctc gctatggcga
     8881 actctgacgg gggccggaac accggaaaag accgcactgg ggtgccgcct tttcctctca
     8941 cacgctgggg cgtgctcgtt gttcctccgg ggctgcgcct tttccgcatg gggcggaaag
     9001 aggctggcct ccgtggtgaa agctgaacgc aatcaccacg gacgtgaccg ccgccgccat
     9061 gccttggggc atgtccgcgg cttgtgcagc gggggctgca catcacgccg gcaaaccatc
     9121 gtctgaagga gagagaacat gtttaatacg gattcgcttg cctggaagtg gcacattccg
     9181 gagctggccc ggcagattta tccgtgggtc agctggctgt accaggagta ttacggtctg
     9241 gccggggctt tcctagttat cggcctgttt ttcggtctgg ctgaactttg ggcc
//
