LOCUS       CP052424                9294 bp    DNA     circular BCT 04-MAY-2020
DEFINITION  Klebsiella pneumoniae strain C16KP0164 plasmid pC16KP0164-2,
            complete sequence.
ACCESSION   CP052424
VERSION     CP052424.1
DBLINK      BioProject: PRJNA625837
            BioSample: SAMN14609894
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 9294)
  AUTHORS   Yoon,E.-J., Gwon,B., Liu,C., Kim,D., Won,D., Park,S.G., Choi,J.R.
            and Jeong,S.H.
  TITLE     Built-in CTX-M extended-spectrum beta-lactamase gene in Klebsiella
            pneumoniae ensuring stable propagation of the multidrug-resistant
            pathogen in clinical settings
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9294)
  AUTHORS   Yoon,E.-J., Gwon,B., Liu,C., Kim,D., Won,D., Park,S.G., Choi,J.R.
            and Jeong,S.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-APR-2020) Research Institute of Bacterial Resistance,
            Yonsei University College of Medicine, 211, Eonjuro, Gangnam-Gu,
            Seoul 06273, Korea, Republic of
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: Oxford Nanopore and Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/27/2020 20:56:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 5,455
            CDSs (total)                      :: 5,331
            Genes (coding)                    :: 5,192
            CDSs (with protein)               :: 5,192
            Genes (RNA)                       :: 124
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 89
            ncRNAs                            :: 10
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 73 of 139
            Pseudo Genes (incomplete)         :: 63 of 139
            Pseudo Genes (internal stop)      :: 22 of 139
            Pseudo Genes (multiple problems)  :: 18 of 139
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..9294
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="C16KP0164"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="pC16KP0164-2"
                     /geo_loc_name="South Korea: Gangwon"
                     /lat_lon="37.82 N 128.16 E"
                     /collection_date="2016"
                     /collected_by="Kor-GLASS"
     gene            join(9276..9294,1..512)
                     /locus_tag="HJX06_27185"
     CDS             join(9276..9294,1..512)
                     /locus_tag="HJX06_27185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QJK84056.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(540..719)
                     /locus_tag="HJX06_27190"
     CDS             complement(540..719)
                     /locus_tag="HJX06_27190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="QJK84057.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            788..1165
                     /locus_tag="HJX06_27195"
     CDS             788..1165
                     /locus_tag="HJX06_27195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="entry exclusion protein 1"
                     /protein_id="QJK84058.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="entry exclusion protein 1"
     gene            complement(1227..1526)
                     /locus_tag="HJX06_27200"
     CDS             complement(1227..1526)
                     /locus_tag="HJX06_27200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="QJK84059.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(1516..1779)
                     /locus_tag="HJX06_27205"
     CDS             complement(1516..1779)
                     /locus_tag="HJX06_27205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid stabilization protein"
                     /protein_id="QJK84060.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="plasmid stabilization protein"
     gene            complement(2085..2504)
                     /gene="exc2"
                     /locus_tag="HJX06_27210"
     CDS             complement(2085..2504)
                     /gene="exc2"
                     /locus_tag="HJX06_27210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /protein_id="QJK84061.1"
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
                     /name="exc2"
     gene            2907..4592
                     /locus_tag="HJX06_27215"
     CDS             2907..4592
                     /locus_tag="HJX06_27215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="QJK84062.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="cloacin"
     gene            4602..4859
                     /locus_tag="HJX06_27220"
     CDS             4602..4859
                     /locus_tag="HJX06_27220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="QJK84063.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin"
     gene            4944..5093
                     /locus_tag="HJX06_27225"
     CDS             4944..5093
                     /locus_tag="HJX06_27225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="QJK84064.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            6574..8538
                     /locus_tag="HJX06_27230"
     CDS             6574..8538
                     /locus_tag="HJX06_27230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="QJK84065.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     gene            8538..9269
                     /locus_tag="HJX06_27235"
     CDS             8538..9269
                     /locus_tag="HJX06_27235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication-relaxation family protein"
                     /protein_id="QJK84066.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="replication-relaxation family protein"
     BGC             1..9294
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          complement(5197..5775)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          8539..9266
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.32e-150"
ORIGIN
        1 ttattgaaga cgcggaggac cggaacggcg agcgctgcat catgccgacc agcgagcatc
       61 tggaagatat ggtggtgctc gcctggcaga ccggggcgta tgttttctgt tttgtcgacc
      121 gggcccagca tctggcgatg atgaaatcca tcgggatgta tgacgagcgg ctcaacagcg
      181 acgaaaaagc cacgtacttt ttcactggta aaaatccgca atgggaacgg aacaaaccca
      241 caggaatgaa gctgtgtgat tacctctatc gcaaggtgga gcggttcgcc atcgagaacg
      301 gtgtgcaggt ggttgatgcc gggaagtgct caccggagca gattaacgcg atgattgacg
      361 tggtgagtga gcggcacggg gaaagcgcgg tgaacgagaa gctgaaagcg gagctgatgc
      421 gggaatataa cagccgctat tttaacgtgc cggtacctga actgccggag gacaaacctg
      481 cccgccggtg gtggccgttc ggcaaaaaat aaatgccagc accggccatg ccggtgctgt
      541 tattcctccc cgagcttatc ccgcatcacc tgccagagtg tttccgcatc ctcgtgtagc
      601 cgctcgcaca tgtcggccgg ggtatccata tccagctcat tcagtttatc gagcaatagc
      661 agcgactgct ccttaataaa tttagccata ttgagggctg ttttttcctg ttttgtcatg
      721 attctttcct tccgggcatg gtgtgcgcct gtcaggtata ctgtctcaaa aatagcgggg
      781 tgagacaatg gcgtgggtga cggtgagaca ggcgacggaa ctgacgggta aagcccgaag
      841 ttccctgtat cgggatatgg cgaaaggccg cgtatcatac cgtacggaag ctgatggcgg
      901 ccgggtggtg gataccagcg agcttatccg ggtgtacggt gagttaagac aggatgagac
      961 tcacgagcgg gacgagttga gactgtcggg tgagactgaa aaaatggcct ccgacgcgtt
     1021 gatcgcggag ataaaagcac tcagggagga ggtggccggg ctacggcagg aaatgcagtc
     1081 catgagactg ctggaacaca aaccggagac agcagagacc ccggccggaa caccgcgccg
     1141 gtggtggccg tggggaaaac gctgacgcgc tgtgcttgtc caaccggcga cggccacgca
     1201 atgaattgcg tccccgtcac cggttattag agaacaatat ggggattctg gcgctggccg
     1261 accacggcca gaacccggac ttttctggtc tggtcatcaa catcatagag gacatgctgt
     1321 cccatcagac tgatccggcg aacgtcctcg ccatagcgtg agtccacttc atagagtcgc
     1381 gggaagtcgg ccagtttgtc cgccgcagcg agaacccggt cggtaacgtt ctgcgcatcc
     1441 cacagggatg aattttccgc gatatagtca aacagcgtcg ttacatcctc gatggctccc
     1501 tgcttccatt ccacgtcata cggcatcgcg cagttcctga taacggccat gcaggcgctg
     1561 gcggagttgt tccgtggtca tacccggacg cgtgtcagca cgggcggcgg tcactttggc
     1621 gcgaacctga tcttcatact ctgcctgggc cagttcttcg ttagccagtc gctgcaacag
     1681 cgcagctttg tccgggccac cttccggcag tatgcggggc aggctttcag ccagttcccg
     1741 aagaaagttg gcgttttcgt agtgtgtagt gttgctcatt gcggagcctc ccgggttaat
     1801 gcggcaatat gaaggaagtt tagcaggggg cggtctgaaa gaatatggtc gtgtcagtca
     1861 ggctgatgaa gcagaaagtc ggtaaaaaag ggcttacggc atccatttta cgtcaaaaca
     1921 tatgccatgc agttgcgtgc ataggcatgc attaggataa aatttatcgg gcgcgtttcc
     1981 ggcagttttc cgggggggtt gttgcctgtt ttatcccgta gccgccggaa acgccctgag
     2041 cccgtctgag cggtgcgcgt aatgacgcgt tatggtaaat ccacttactg tctgccttca
     2101 tagccatcga gataaacagc tgaaatggtg tcagccagta gccttgattt tttcggtgtg
     2161 aggtctttgc tgcggtaatc ggtacccgca aattgtgttg tgccttggag tgagtttaaa
     2221 aattcctgac tgtgaaactg ctgaatgcgt tgctgcacat cactccgtga ttttccggtc
     2281 gctttatcct ttgcgcccat atcccagaac tgccggaaaa aaggcaccat cattcgtgtt
     2341 gtgtcagctt tctgggtgga aaaattggga tcaaaaccgt catctgaagc atatacgtaa
     2401 tgccgggtat gctgttccac gctgcccttt ggagcacagg cagtgagagt tgctgtcgct
     2461 gttatcatgg cgataagaca cagtttgctg ccggaacgtc tcatgagcgt ctccttacct
     2521 ttaattcttt tttctcattg agttatatat ccgcaggcta tcttatcatc agtttctgac
     2581 cgtgttcagt gaccgaacaa cccgaaccag accccccgtt tcttttcctg tcccggaggg
     2641 ggctttctgg tatctcatat aatgatttca gtaaaacata ctgaggccgg agaacggcgc
     2701 cgtttgtgct ggtttttgtt gcatctggag gggattgcgc atggtgtgag tggctgtttt
     2761 tttgatcatt ttcacaaaaa cgcaaattta cagacttgac atgaaaaaca aggcagcgta
     2821 atttttatac tgtatataaa accagtggtt atatgtacag tattttattt tagtttattg
     2881 ttttaaaagt caaagaggaa aagtatatga gtggcggaga cggacgaggt ccgggtaatt
     2941 caggtctggg acacaatggt ggtcaggcca gtgggaatgt gaacggtaca tcaggtaaag
     3001 gtggcccttc atcaggtggt ggtacggatc caaacagcgg gccgggctgg ggtacgacgc
     3061 atacacctaa cggggatatt cataactata acccggggga gtttggtaac ggcgggagta
     3121 aacccggtgg taatggcggt aacagcggca atcatagcgg gagctctggt ggcggacagt
     3181 cttcggccac cgcgatggcc ttcggtctgc ctgccctggc cactccgggg gctgaaggac
     3241 tggctttatc cgtttccggc gatgcgttgt cggccgctgt tgctgatgtg ctggctgccc
     3301 tgaaaggtcc gtttaagttt ggtctgtggg ggattgcgat ttacggagtg ctgccttctg
     3361 agatagcaaa agatgatccg aaaatgatgt caaaaatcgt gacgtcattg ccggcagaca
     3421 cggtaacgga gacgccggtc agctccctgc cgctggacca ggcgacggtc agcgtcacta
     3481 aacgtgtggc ggatattgtg aaggacgagc ggcagcatat tgcggttgtc accggccggc
     3541 caatgagtgt tcctgtggtg gatgcgaaac cgacaaaacg tccgggggta ttcagtgtgt
     3601 cgattccggg tctcccgtct ctgcaggtga gcgtacctaa aggtgttccg gccgcgaaag
     3661 ccccgccaaa aggcattatt gctgaaaaag gtgattcacg tccggctggt tttacggccg
     3721 gtggtaactc ccgtgaggcc gttattcgtt tcccgaaaga gagcggacag aaaccggtct
     3781 atgtgtcggt gacggatgtt cttactccgg cacaggtaaa acagcgtctg gaggaagaaa
     3841 agcgtcgcca gcaggcatgg gacgctgctc acccggaaga ggggctgaaa agagagtatg
     3901 ataaagcgaa agctgagctg gatgctgaag ataaaaatat tgcgacctta aacagtcgca
     3961 ttgcatcgac agagaaggcg atccccggtg caagggctgc tgttcaggaa gccgataaaa
     4021 aggtaaaaga ggcagaggca aataaagatg attttgtgac ttataacccg cctcatgaat
     4081 atggctccgg gtggcaggat caggttcgct atcttgataa ggatattcag aatcagaatg
     4141 agaaattaaa agctgcccag acatctttaa acgaaatgaa tgaatcctta tccagggata
     4201 aggctgcgct ttccggggcg atggagagcc ggaaacaaaa ggagaaaaaa gcgaaggatg
     4261 cagaaaataa attaaatgag gaaaagaaaa aacctcgtaa gggaactaaa gattacggcc
     4321 atgattattt tcctgatccc aagactgaag atattaaggg gttgggagag ttgaaagagg
     4381 gtaaacctaa aacccctaaa caaggtggtg gtggtaagcg ggcccgatgg tatggtgata
     4441 aaaagcgtaa aatttatgaa tgggattccc agcacggtga gcttgaaggg taccgcgcca
     4501 gtgatggcga acacctcggg gcattcgatc caaaaacggg taagcaggtt aaagggccgg
     4561 atccaaaacg aaacattaaa aaatatcttt aagaggtaaa tatggggctt aaattacata
     4621 ttcattggtt tgataagaaa accgaagagt ttaaaggtgg tgaatactca aaagacttcg
     4681 gtgatgatgg ttctgtcatt gaaagtctgg ggatgccttt aaaggataat attaataatg
     4741 gttggtttga tgttgaaaaa tcatgggttt cgatattaca gccacacttt aaaaatgtaa
     4801 tcgatattag taaatttgat tactttgtat cctttgttta ccgggatggt aactggtaag
     4861 caaaagttat caaggatgat ttgaaataca gacttccggt gttcagggat gaataccggg
     4921 gtttttaaat acagggaagg tatatgaaaa aggtaaaggt tgtttttctt tttatattga
     4981 ttttttcagg ctttcttctg gtcgcatgtc aggcaaacta tatccgggat gttcagggtg
     5041 gaacggtggc accatcgtcc tcctctgaac tgacggggat cgcggttcag tagaaaagat
     5101 caaaggatct tcttgagatc ctttttttct gcgcgtaatc ttttgccctg taaacgaaaa
     5161 aaccacctgg ggaggtggtt tgatcgaagg ttaagtcagt tggggaactg cttaaccgtg
     5221 gtaactggct ttcgcagagc acagcaacca aatctgtcct tccagtgtag ccggactttg
     5281 gcgcacactt caagagcaac cgcgtgttta gctaaacaaa tcctctgcga actcccagtt
     5341 accaatggct gctgccagtg gcgttttgcg tgcttttccg ggttggactc aagtgaacag
     5401 ttaccggata aggcgcagca gtcgggctga acggggggtt cttgcttaca gcccagcttg
     5461 gagcgaacga cctacaccga gccgagatac cagagtgtga gctatgagaa agcgccacac
     5521 ttcccgcaag ggagaaaggc ggaacaggta tccgggaaac ggcagggttg gaacaggaga
     5581 gcgcaagagg gagcgattca tcggaaacgg tgatgatctt taagtcctgt cgggtttcgc
     5641 cactcctgac tgattcatgg ttgagccacc ggctcccaca gatgcaccga aaaagcgtct
     5701 gtttatgtga actcagtcag gagggcggag cctatggaaa aacgccacct gcgtggcctt
     5761 gccgttttgc ctcacatgtt agtcccctgc ttattcacgg aatctgtggg taactttgca
     5821 tgtgtccgca gcgcccgccg cagtctcacg gccggagcgt agcgaccgag tgagcgagga
     5881 ggcgcaattt ccccggcacc tacaagacgg acaccggacg cgctgatgtg gcatattgtc
     5941 ccctgattaa gtctttatat tccctgataa taaattacca ggataggtga atcatatcgg
     6001 tttttcgctg aacattttac gttaacctat ctctgttgct tttttctcct tacggagaaa
     6061 tacaggtcat ccccgcgagg gcgtggctga cctcaggggg atatcccctg cttacgctgg
     6121 ctggacgcca ccgacgcacg gtctctcccc ctctttctgg ctccgtccgg ctggacgccg
     6181 gccacgccag aaattcaccc ggcccccgtc aggctcacgc ctgaccaccc acaaaaatcc
     6241 acggtgctgg acgcacctgg cgaagcagca aagctgctcc tgattttgcg ggtggtcagc
     6301 cgctcgctat ggcgaactct gacgggggcc ggaacaccgg aaaagaccgc actggggtgc
     6361 cgccttttcc tctcacacgc tggggcgtgc tcgttgttcc tccggggctg cgccttttcc
     6421 gcatggggcg gaaagaggct ggcctccgtg gtgaaagctg aacgcaatca ccacggacgt
     6481 gaccgccgcc gccatgcctt ggggcatgtc cgcggcttgt gcagcggggg ctgcacatca
     6541 cgccggcaaa ccatcgtctg aaggagagag aacatgttta atacggattc gcttgcctgg
     6601 aagtggcaca ttccggagct ggcccggcag atttatccgt gggtcagctg gctgtaccag
     6661 gagtattacg gtctggccgg ggctttccta gttatcggcc tgtttttcgg tctggctgaa
     6721 ctttgggccg gacggatgcg ttttgtgggg ctgagtcata aggagcgacg ggagtatgcc
     6781 gatcgctata agcgcgataa taaacggcca gcgccatttt cggtgctggc ctcgctggat
     6841 tcgcccgggc ggatggtcag ggcacgtcga catgtctgga actacgcgta ctggctgacc
     6901 ggcgcggccg gtctggccct tctggggggg ctggttgtcg ccgtgtttat cgagagctgg
     6961 ggagaaaccg tcctgcgtcc ggacctctac gcaaacgcag attattacct gctgcagccg
     7021 gctaacctgt tcgggattgc ctggtgcgcg ggcgggctgg ctgtcgggat tgtgttggcg
     7081 cggctgctgg cgttcctgct gcttgacggt cattttgcgg ctgctgacga ggcggtgaac
     7141 gcgaaactga atcaggagag ccggcgcagc agccagcgga caggagagat gaccgacgtg
     7201 cgccacctgc atttcgggga gccggtaccg gttaatgcgc tggccgattt ttcctcggag
     7261 caggcccggc aggagcaggc ggtgtttctg ggtaaggatg agcagggcaa gccggtgctg
     7321 gttccgcgtg atacctggcg caagaccaac attcagatcc tcggcctgcc cgggagcggc
     7381 aagagcgtga tggccaccaa cgcgctcatt cgctgcgtac gcgatttcgg ggacgcggtg
     7441 gtgtacttcg accccaaagg ggacgcatgg gcgccgcacg tcttccgggc gcactgtccg
     7501 gacttcaccc tgctggatct gcggccgggg aaaccggcgc agctgaatct gttccgcgat
     7561 ctcgaccagt acgcgctgaa aaacctgctg attgccgggc ttaacctggg cgagaccggc
     7621 gacgtggcgg accactaccg catcagcgag cagaaagcgg cgaagctgat tgcggagcag
     7681 tttccgcagg gggcaaacat tcagcaggtg ctggcggcgg cgtacgcgct gccggaggcc
     7741 ctgaaaaagg acgtgaaggg gttgatcact aggctggaaa acgtcgctga cctgagcgtc
     7801 ctgcagacgg acagtggcat cgatgtggcg gggattatca acggcggcgg ctgcctgtac
     7861 gttatcggct cgatggacga cgaggcggtg atccgtgtgc aaaaaatgct gtttgcccgc
     7921 tgcgcgcaaa tcatcattgc gcgggacgag ttccgggagt ggccacacgt cagcgtgatg
     7981 ctcgatgaaa ttaaatatct gctgtcgaag tatgtactga acgcactggg gacgctgcgc
     8041 agccgggact gcaatctgtt gctcgcgcac cagtcgctgg gcgatttcgg gcagtgcggg
     8101 caggatctgc ccgctgaatt tgtgaaaacc acggtactgg ataacacgcc gatccgctgg
     8161 ttttaccggg cggccagcct ggagtccgcg cagtgggcgg cggggcagac cggggaaatc
     8221 agggtggacg tggagcgccg ccgtgccagc cgggaggcgg ggaacgtgga gcatatcagc
     8281 ggggacagct tcatccagaa ggaggcgcgg ccgctgtttg acgtgaacac cctgcaacac
     8341 ctgccggacg ggttcgcggt catgaccggg ctgggtgtgg cccggatggc gttcagcagt
     8401 ccgctgcggg ttgagcgccg ggaaatcccg ttgcagcgtt tcccggtgct ggcgaaaacc
     8461 gatcccctgg cggagttccg gcccccggcc gacggcggcg ggccgaaagc ggatgatgat
     8521 tttgcgggga tttactgatg gcgctggagc tgtacaacgt cagccacgcg aaacgacagg
     8581 cgcggaacgc ggagaaaacc cggctgaccc tgcgctggtt gcgggaagag ctgtgttcca
     8641 cggcggagct ggttgcgcgg cggctgggga ttgcggcggt gcagccggtc taccgcttcc
     8701 tcgacagcct ggtggcgaaa gggctgctgg tccggaccaa atatccggtg gacggccgtc
     8761 aggtcagcgt gtgggggctg acgccgcatg gcgtggcgtt ctcgttcgac gaggacgaac
     8821 cgctggcgga tgttattccg tttcagccgt caagggtgtc ggcagcacat ctgccgcacc
     8881 ggctggccgt gcaatccctg cgccttgata tggaagccag aggggccacc ggctggcgca
     8941 ttctgcaccg tctgagtctt aaaggcatga aagtgccgga cgccctggcg gagctggacg
     9001 gtaaaacggt ggcgtttgag gtggagcgca ccgtcaagag ccgtcgccgg tatcaggaag
     9061 tggtgtccgg gtatctgttc aaccgcaaag ctaacggcat cgatgaaatc tggtacatct
     9121 gcccggaccg ggcgacgcag gtcagggtgc agcgggcaat cctgtcggtg gatgaaatcg
     9181 tgaacccaca gaccggcgag gcccgcaaaa cggcagagct ggatcgtgaa cggttgtttg
     9241 cgtgctttaa atttatgaca acggagtgag ggattatggc gctgtacatg gtat
//
