LOCUS       CP052171                9294 bp    DNA     circular BCT 04-MAY-2020
DEFINITION  Klebsiella pneumoniae strain F16KP0075 plasmid pF16KP0075-4,
            complete sequence.
ACCESSION   CP052171
VERSION     CP052171.1
DBLINK      BioProject: PRJNA625837
            BioSample: SAMN14609963
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 9294)
  AUTHORS   Yoon,E.-J., Gwon,B., Liu,C., Kim,D., Won,D., Park,S.G., Choi,J.R.
            and Jeong,S.H.
  TITLE     Built-in CTX-M extended-spectrum beta-lactamase gene in Klebsiella
            pneumoniae ensuring stable propagation of the multidrug-resistant
            pathogen in clinical settings
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9294)
  AUTHORS   Yoon,E.-J., Gwon,B., Liu,C., Kim,D., Won,D., Park,S.G., Choi,J.R.
            and Jeong,S.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-APR-2020) Research Institute of Bacterial Resistance,
            Yonsei University College of Medicine, 211, Eonjuro, Gangnam-Gu,
            Seoul 06273, Korea, Republic of
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: Oxford Nanopore and Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/27/2020 20:42:59
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 5,889
            CDSs (total)                      :: 5,768
            Genes (coding)                    :: 5,619
            CDSs (with protein)               :: 5,619
            Genes (RNA)                       :: 121
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 85
            ncRNAs                            :: 11
            Pseudo Genes (total)              :: 149
            CDSs (without protein)            :: 149
            Pseudo Genes (ambiguous residues) :: 0 of 149
            Pseudo Genes (frameshifted)       :: 65 of 149
            Pseudo Genes (incomplete)         :: 79 of 149
            Pseudo Genes (internal stop)      :: 21 of 149
            Pseudo Genes (multiple problems)  :: 16 of 149
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..9294
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="F16KP0075"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="pF16KP0075-4"
                     /geo_loc_name="South Korea: Busan"
                     /lat_lon="35.18 N 129.08 E"
                     /collection_date="2016"
                     /collected_by="Kor-GLASS"
     gene            complement(join(8617..9294,1..1287))
                     /locus_tag="HJX75_29395"
     CDS             complement(join(8617..9294,1..1287))
                     /locus_tag="HJX75_29395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="QJO00862.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     gene            complement(2768..2917)
                     /locus_tag="HJX75_29400"
     CDS             complement(2768..2917)
                     /locus_tag="HJX75_29400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="QJO00852.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            complement(3002..3259)
                     /locus_tag="HJX75_29405"
     CDS             complement(3002..3259)
                     /locus_tag="HJX75_29405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="QJO00853.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin"
     gene            complement(3269..4954)
                     /locus_tag="HJX75_29410"
     CDS             complement(3269..4954)
                     /locus_tag="HJX75_29410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="QJO00854.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="cloacin"
     gene            5357..5776
                     /gene="exc2"
                     /locus_tag="HJX75_29415"
     CDS             5357..5776
                     /gene="exc2"
                     /locus_tag="HJX75_29415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /protein_id="QJO00855.1"
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
                     /name="exc2"
     gene            6082..6345
                     /locus_tag="HJX75_29420"
     CDS             6082..6345
                     /locus_tag="HJX75_29420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid stabilization protein"
                     /protein_id="QJO00856.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="plasmid stabilization protein"
     gene            6335..6634
                     /locus_tag="HJX75_29425"
     CDS             6335..6634
                     /locus_tag="HJX75_29425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="QJO00857.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(6696..7073)
                     /locus_tag="HJX75_29430"
     CDS             complement(6696..7073)
                     /locus_tag="HJX75_29430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="entry exclusion protein 1"
                     /protein_id="QJO00858.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="entry exclusion protein 1"
     gene            7142..7321
                     /locus_tag="HJX75_29435"
     CDS             7142..7321
                     /locus_tag="HJX75_29435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="QJO00859.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(7349..7879)
                     /locus_tag="HJX75_29440"
     CDS             complement(7349..7879)
                     /locus_tag="HJX75_29440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QJO00860.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(7886..8617)
                     /locus_tag="HJX75_29445"
     CDS             complement(7886..8617)
                     /locus_tag="HJX75_29445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication-relaxation family protein"
                     /protein_id="QJO00861.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="replication-relaxation family protein"
     BGC             1..9294
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          2087..2665
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(7890..8617)
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.32e-150"
ORIGIN
        1 gtacaggcag ccgccgccgt tgataatccc cgccacatcg atgccactgt ccgtctgcag
       61 gacgctcagg tcagcgacgt tttccagcct agtgatcaac cccttcacgt cctttttcag
      121 ggcctccggc agcgcgtacg ccgccgccag cacctgctga atgtttgccc cctgcggaaa
      181 ctgctccgca atcagcttcg ccgctttctg ctcgctgatg cggtagtggt ccgccacgtc
      241 gccggtctcg cccaggttaa gcccggcaat cagcaggttt ttcagcgcgt actggtcgag
      301 atcgcggaac agattcagct gcgccggttt ccccggccgc agatccagca gggtgaagtc
      361 cggacagtgc gcccggaaga cgtgcggcgc ccatgcgtcc cctttggggt cgaagtacac
      421 caccgcgtcc ccgaaatcgc gtacgcagcg aatgagcgcg ttggtggcca tcacgctctt
      481 gccgctcccg ggcaggccga ggatctgaat gttggtcttg cgccaggtat cacgcggaac
      541 cagcaccggc ttgccctgct catccttacc cagaaacacc gcctgctcct gccgggcctg
      601 ctccgaggaa aaatcggcca gcgcattaac cggtaccggc tccccgaaat gcaggtggcg
      661 cacgtcggtc atctctcctg tccgctggct gctgcgccgg ctctcctgat tcagtttcgc
      721 gttcaccgcc tcgtcagcag ccgcaaaatg accgtcaagc agcaggaacg ccagcagccg
      781 cgccaacaca atcccgacag ccagcccgcc cgcgcaccag gcaatcccga acaggttagc
      841 cggctgcagc aggtaataat ctgcgtttgc gtagaggtcc ggacgcagga cggtttctcc
      901 ccagctctcg ataaacacgg cgacaaccag cccccccaga agggccagac cggccgcgcc
      961 ggtcagccag tacgcgtagt tccagacatg tcgacgtgcc ctgaccatcc gcccgggcga
     1021 atccagcgag gccagcaccg aaaatggcgc tggccgttta ttatcgcgct tatagcgatc
     1081 ggcatactcc cgtcgctcct tatgactcag ccccacaaaa cgcatccgtc cggcccaaag
     1141 ttcagccaga ccgaaaaaca ggccgataac taggaaagcc ccggccagac cgtaatactc
     1201 ctggtacagc cagctgaccc acggataaat ctgccgggcc agctccggaa tgtgccactt
     1261 ccaggcaagc gaatccgtat taaacatgtt ctctctcctt cagacgatgg tttgccggcg
     1321 tgatgtgcag cccccgctgc acaagccgcg gacatgcccc aaggcatggc ggcggcggtc
     1381 acgtccgtgg tgattgcgtt cagctttcac cacggaggcc agcctctttc cgccccatgc
     1441 ggaaaaggcg cagccccgga ggaacaacga gcacgcccca gcgtgtgaga ggaaaaggcg
     1501 gcaccccagt gcggtctttt ccggtgttcc ggcccccgtc agagttcgcc atagcgagcg
     1561 gctgaccacc cgcaaaatca ggagcagctt tgctgcttcg ccaggtgcgt ccagcaccgt
     1621 ggatttttgt gggtggtcag gcgtgagcct gacgggggcc gggtgaattt ctggcgtggc
     1681 cggcgtccag ccggacggag ccagaaagag ggggagagac cgtgcgtcgg tggcgtccag
     1741 ccagcgtaag caggggatat ccccctgagg tcagccacgc cctcgcgggg atgacctgta
     1801 tttctccgta aggagaaaaa agcaacagag ataggttaac gtaaaatgtt cagcgaaaaa
     1861 ccgatatgat tcacctatcc tggtaattta ttatcaggga atataaagac ttaatcaggg
     1921 gacaatatgc cacatcagcg cgtccggtgt ccgtcttgta ggtgccgggg aaattgcgcc
     1981 tcctcgctca ctcggtcgct acgctccggc cgtgagactg cggcgggcgc tgcggacaca
     2041 tgcaaagtta cccacagatt ccgtgaataa gcaggggact aacatgtgag gcaaaacggc
     2101 aaggccacgc aggtggcgtt tttccatagg ctccgccctc ctgactgagt tcacataaac
     2161 agacgctttt tcggtgcatc tgtgggagcc ggtggctcaa ccatgaatca gtcaggagtg
     2221 gcgaaacccg acaggactta aagatcatca ccgtttccga tgaatcgctc cctcttgcgc
     2281 tctcctgttc caaccctgcc gtttcccgga tacctgttcc gcctttctcc cttgcgggaa
     2341 gtgtggcgct ttctcatagc tcacactctg gtatctcggc tcggtgtagg tcgttcgctc
     2401 caagctgggc tgtaagcaag aaccccccgt tcagcccgac tgctgcgcct tatccggtaa
     2461 ctgttcactt gagtccaacc cggaaaagca cgcaaaacgc cactggcagc agccattggt
     2521 aactgggagt tcgcagagga tttgtttagc taaacacgcg gttgctcttg aagtgtgcgc
     2581 caaagtccgg ctacactgga aggacagatt tggttgctgt gctctgcgaa agccagttac
     2641 cacggttaag cagttcccca actgacttaa ccttcgatca aaccacctcc ccaggtggtt
     2701 ttttcgttta cagggcaaaa gattacgcgc agaaaaaaag gatctcaaga agatcctttg
     2761 atcttttcta ctgaaccgcg atccccgtca gttcagagga ggacgatggt gccaccgttc
     2821 caccctgaac atcccggata tagtttgcct gacatgcgac cagaagaaag cctgaaaaaa
     2881 tcaatataaa aagaaaaaca acctttacct ttttcatata ccttccctgt atttaaaaac
     2941 cccggtattc atccctgaac accggaagtc tgtatttcaa atcatccttg ataacttttg
     3001 cttaccagtt accatcccgg taaacaaagg atacaaagta atcaaattta ctaatatcga
     3061 ttacattttt aaagtgtggc tgtaatatcg aaacccatga tttttcaaca tcaaaccaac
     3121 cattattaat attatccttt aaaggcatcc ccagactttc aatgacagaa ccatcatcac
     3181 cgaagtcttt tgagtattca ccacctttaa actcttcggt tttcttatca aaccaatgaa
     3241 tatgtaattt aagccccata tttacctctt aaagatattt tttaatgttt cgttttggat
     3301 ccggcccttt aacctgctta cccgtttttg gatcgaatgc cccgaggtgt tcgccatcac
     3361 tggcgcggta cccttcaagc tcaccgtgct gggaatccca ttcataaatt ttacgctttt
     3421 tatcaccata ccatcgggcc cgcttaccac caccaccttg tttaggggtt ttaggtttac
     3481 cctctttcaa ctctcccaac cccttaatat cttcagtctt gggatcagga aaataatcat
     3541 ggccgtaatc tttagttccc ttacgaggtt ttttcttttc ctcatttaat ttattttctg
     3601 catccttcgc ttttttctcc ttttgtttcc ggctctccat cgccccggaa agcgcagcct
     3661 tatccctgga taaggattca ttcatttcgt ttaaagatgt ctgggcagct tttaatttct
     3721 cattctgatt ctgaatatcc ttatcaagat agcgaacctg atcctgccac ccggagccat
     3781 attcatgagg cgggttataa gtcacaaaat catctttatt tgcctctgcc tcttttacct
     3841 ttttatcggc ttcctgaaca gcagcccttg caccggggat cgccttctct gtcgatgcaa
     3901 tgcgactgtt taaggtcgca atatttttat cttcagcatc cagctcagct ttcgctttat
     3961 catactctct tttcagcccc tcttccgggt gagcagcgtc ccatgcctgc tggcgacgct
     4021 tttcttcctc cagacgctgt tttacctgtg ccggagtaag aacatccgtc accgacacat
     4081 agaccggttt ctgtccgctc tctttcggga aacgaataac ggcctcacgg gagttaccac
     4141 cggccgtaaa accagccgga cgtgaatcac ctttttcagc aataatgcct tttggcgggg
     4201 ctttcgcggc cggaacacct ttaggtacgc tcacctgcag agacgggaga cccggaatcg
     4261 acacactgaa tacccccgga cgttttgtcg gtttcgcatc caccacagga acactcattg
     4321 gccggccggt gacaaccgca atatgctgcc gctcgtcctt cacaatatcc gccacacgtt
     4381 tagtgacgct gaccgtcgcc tggtccagcg gcagggagct gaccggcgtc tccgttaccg
     4441 tgtctgccgg caatgacgtc acgatttttg acatcatttt cggatcatct tttgctatct
     4501 cagaaggcag cactccgtaa atcgcaatcc cccacagacc aaacttaaac ggacctttca
     4561 gggcagccag cacatcagca acagcggccg acaacgcatc gccggaaacg gataaagcca
     4621 gtccttcagc ccccggagtg gccagggcag gcagaccgaa ggccatcgcg gtggccgaag
     4681 actgtccgcc accagagctc ccgctatgat tgccgctgtt accgccatta ccaccgggtt
     4741 tactcccgcc gttaccaaac tcccccgggt tatagttatg aatatccccg ttaggtgtat
     4801 gcgtcgtacc ccagcccggc ccgctgtttg gatccgtacc accacctgat gaagggccac
     4861 ctttacctga tgtaccgttc acattcccac tggcctgacc accattgtgt cccagacctg
     4921 aattacccgg acctcgtccg tctccgccac tcatatactt ttcctctttg acttttaaaa
     4981 caataaacta aaataaaata ctgtacatat aaccactggt tttatataca gtataaaaat
     5041 tacgctgcct tgtttttcat gtcaagtctg taaatttgcg tttttgtgaa aatgatcaaa
     5101 aaaacagcca ctcacaccat gcgcaatccc ctccagatgc aacaaaaacc agcacaaacg
     5161 gcgccgttct ccggcctcag tatgttttac tgaaatcatt atatgagata ccagaaagcc
     5221 ccctccggga caggaaaaga aacggggggt ctggttcggg ttgttcggtc actgaacacg
     5281 gtcagaaact gatgataaga tagcctgcgg atatataact caatgagaaa aaagaattaa
     5341 aggtaaggag acgctcatga gacgttccgg cagcaaactg tgtcttatcg ccatgataac
     5401 agcgacagca actctcactg cctgtgctcc aaagggcagc gtggaacagc atacccggca
     5461 ttacgtatat gcttcagatg acggttttga tcccaatttt tccacccaga aagctgacac
     5521 aacacgaatg atggtgcctt ttttccggca gttctgggat atgggcgcaa aggataaagc
     5581 gaccggaaaa tcacggagtg atgtgcagca acgcattcag cagtttcaca gtcaggaatt
     5641 tttaaactca ctccaaggca caacacaatt tgcgggtacc gattaccgca gcaaagacct
     5701 cacaccgaaa aaatcaaggc tactggctga caccatttca gctgtttatc tcgatggcta
     5761 tgaaggcaga cagtaagtgg atttaccata acgcgtcatt acgcgcaccg ctcagacggg
     5821 ctcagggcgt ttccggcggc tacgggataa aacaggcaac aacccccccg gaaaactgcc
     5881 ggaaacgcgc ccgataaatt ttatcctaat gcatgcctat gcacgcaact gcatggcata
     5941 tgttttgacg taaaatggat gccgtaagcc cttttttacc gactttctgc ttcatcagcc
     6001 tgactgacac gaccatattc tttcagaccg ccccctgcta aacttccttc atattgccgc
     6061 attaacccgg gaggctccgc aatgagcaac actacacact acgaaaacgc caactttctt
     6121 cgggaactgg ctgaaagcct gccccgcata ctgccggaag gtggcccgga caaagctgcg
     6181 ctgttgcagc gactggctaa cgaagaactg gcccaggcag agtatgaaga tcaggttcgc
     6241 gccaaagtga ccgccgcccg tgctgacacg cgtccgggta tgaccacgga acaactccgc
     6301 cagcgcctgc atggccgtta tcaggaactg cgcgatgccg tatgacgtgg aatggaagca
     6361 gggagccatc gaggatgtaa cgacgctgtt tgactatatc gcggaaaatt catccctgtg
     6421 ggatgcgcag aacgttaccg accgggttct cgctgcggcg gacaaactgg ccgacttccc
     6481 gcgactctat gaagtggact cacgctatgg cgaggacgtt cgccggatca gtctgatggg
     6541 acagcatgtc ctctatgatg ttgatgacca gaccagaaaa gtccgggttc tggccgtggt
     6601 cggccagcgc cagaatcccc atattgttct ctaataaccg gtgacgggga cgcaattcat
     6661 tgcgtggccg tcgccggttg gacaagcaca gcgcgtcagc gttttcccca cggccaccac
     6721 cggcgcggtg ttccggccgg ggtctctgct gtctccggtt tgtgttccag cagtctcatg
     6781 gactgcattt cctgccgtag cccggccacc tcctccctga gtgcttttat ctccgcgatc
     6841 aacgcgtcgg aggccatttt ttcagtctca cccgacagtc tcaactcgtc ccgctcgtga
     6901 gtctcatcct gtcttaactc accgtacacc cggataagct cgctggtatc caccacccgg
     6961 ccgccatcag cttccgtacg gtatgatacg cggcctttcg ccatatcccg atacagggaa
     7021 cttcgggctt tacccgtcag ttccgtcgcc tgtctcaccg tcacccacgc cattgtctca
     7081 ccccgctatt tttgagacag tatacctgac aggcgcacac catgcccgga aggaaagaat
     7141 catgacaaaa caggaaaaaa cagccctcaa tatggctaaa tttattaagg agcagtcgct
     7201 gctattgctc gataaactga atgagctgga tatggatacc ccggccgaca tgtgcgagcg
     7261 gctacacgag gatgcggaaa cactctggca ggtgatgcgg gataagctcg gggaggaata
     7321 acagcaccgg catggccggt gctggcattt attttttgcc gaacggccac caccggcggg
     7381 caggtttgtc ctccggcagt tcaggtaccg gcacgttaaa atagcggctg ttatattccc
     7441 gcatcagctc cgctttcagc ttctcgttca ccgcgctttc cccgtgccgc tcactcacca
     7501 cgtcaatcat cgcgttaatc tgctccggtg agcacttccc ggcatcaacc acctgcacac
     7561 cgttctcgat ggcgaaccgc tccaccttgc gatagaggta atcacacagc ttcattcctg
     7621 tgggtttgtt ccgttcccat tgcggatttt taccagtgaa aaagtacgtg gctttttcgt
     7681 cgctgttgag ccgctcgtca tacatcccga tggatttcat catcgccaga tgctgggccc
     7741 ggtcgacaaa acagaaaaca tacgccccgg tctgccaggc gagcaccacc atatcttcca
     7801 gatgctcgct ggtcggcatg atgcagcgct cgccgttccg gtcctccgcg tcttcaataa
     7861 ataccatgta cagcgccata atccctcact ccgttgtcat aaatttaaag cacgcaaaca
     7921 accgttcacg atccagctct gccgttttgc gggcctcgcc ggtctgtggg ttcacgattt
     7981 catccaccga caggattgcc cgctgcaccc tgacctgcgt cgcccggtcc gggcagatgt
     8041 accagatttc atcgatgccg ttagctttgc ggttgaacag atacccggac accacttcct
     8101 gataccggcg acggctcttg acggtgcgct ccacctcaaa cgccaccgtt ttaccgtcca
     8161 gctccgccag ggcgtccggc actttcatgc ctttaagact cagacggtgc agaatgcgcc
     8221 agccggtggc ccctctggct tccatatcaa ggcgcaggga ttgcacggcc agccggtgcg
     8281 gcagatgtgc tgccgacacc cttgacggct gaaacggaat aacatccgcc agcggttcgt
     8341 cctcgtcgaa cgagaacgcc acgccatgcg gcgtcagccc ccacacgctg acctgacggc
     8401 cgtccaccgg atatttggtc cggaccagca gccctttcgc caccaggctg tcgaggaagc
     8461 ggtagaccgg ctgcaccgcc gcaatcccca gccgccgcgc aaccagctcc gccgtggaac
     8521 acagctcttc ccgcaaccag cgcagggtca gccgggtttt ctccgcgttc cgcgcctgtc
     8581 gtttcgcgtg gctgacgttg tacagctcca gcgccatcag taaatccccg caaaatcatc
     8641 atccgctttc ggcccgccgc cgtcggccgg gggccggaac tccgccaggg gatcggtttt
     8701 cgccagcacc gggaaacgct gcaacgggat ttcccggcgc tcaacccgca gcggactgct
     8761 gaacgccatc cgggccacac ccagcccggt catgaccgcg aacccgtccg gcaggtgttg
     8821 cagggtgttc acgtcaaaca gcggccgcgc ctccttctgg atgaagctgt ccccgctgat
     8881 atgctccacg ttccccgcct cccggctggc acggcggcgc tccacgtcca ccctgatttc
     8941 cccggtctgc cccgccgccc actgcgcgga ctccaggctg gccgcccggt aaaaccagcg
     9001 gatcggcgtg ttatccagta ccgtggtttt cacaaattca gcgggcagat cctgcccgca
     9061 ctgcccgaaa tcgcccagcg actggtgcgc gagcaacaga ttgcagtccc ggctgcgcag
     9121 cgtccccagt gcgttcagta catacttcga cagcagatat ttaatttcat cgagcatcac
     9181 gctgacgtgt ggccactccc ggaactcgtc ccgcgcaatg atgatttgcg cgcagcgggc
     9241 aaacagcatt ttttgcacac ggatcaccgc ctcgtcgtcc atcgagccga taac
//
