LOCUS       CP052161                9294 bp    DNA     circular BCT 04-MAY-2020
DEFINITION  Klebsiella pneumoniae strain F16KP0084 plasmid pF16KP0084-3,
            complete sequence.
ACCESSION   CP052161
VERSION     CP052161.1
DBLINK      BioProject: PRJNA625837
            BioSample: SAMN14609965
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 9294)
  AUTHORS   Yoon,E.-J., Gwon,B., Liu,C., Kim,D., Won,D., Park,S.G., Choi,J.R.
            and Jeong,S.H.
  TITLE     Built-in CTX-M extended-spectrum beta-lactamase gene in Klebsiella
            pneumoniae ensuring stable propagation of the multidrug-resistant
            pathogen in clinical settings
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9294)
  AUTHORS   Yoon,E.-J., Gwon,B., Liu,C., Kim,D., Won,D., Park,S.G., Choi,J.R.
            and Jeong,S.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-APR-2020) Research Institute of Bacterial Resistance,
            Yonsei University College of Medicine, 211, Eonjuro, Gangnam-Gu,
            Seoul 06273, Korea, Republic of
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: Oxford Nanopore and Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/27/2020 20:04:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 5,568
            CDSs (total)                      :: 5,442
            Genes (coding)                    :: 5,296
            CDSs (with protein)               :: 5,296
            Genes (RNA)                       :: 126
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 15
            Pseudo Genes (total)              :: 146
            CDSs (without protein)            :: 146
            Pseudo Genes (ambiguous residues) :: 0 of 146
            Pseudo Genes (frameshifted)       :: 73 of 146
            Pseudo Genes (incomplete)         :: 71 of 146
            Pseudo Genes (internal stop)      :: 27 of 146
            Pseudo Genes (multiple problems)  :: 23 of 146
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..9294
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="F16KP0084"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="pF16KP0084-3"
                     /geo_loc_name="South Korea: Busan"
                     /lat_lon="35.18 N 129.08 E"
                     /collection_date="2016"
                     /collected_by="Kor-GLASS"
     gene            36..185
                     /locus_tag="HJX77_27790"
     CDS             36..185
                     /locus_tag="HJX77_27790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="QJN89784.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            1666..3630
                     /locus_tag="HJX77_27795"
     CDS             1666..3630
                     /locus_tag="HJX77_27795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="QJN89785.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     gene            3630..4361
                     /locus_tag="HJX77_27800"
     CDS             3630..4361
                     /locus_tag="HJX77_27800"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication-relaxation family protein"
                     /protein_id="QJN89786.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="replication-relaxation family protein"
     gene            4368..4898
                     /locus_tag="HJX77_27805"
     CDS             4368..4898
                     /locus_tag="HJX77_27805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QJN89787.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(4926..5105)
                     /locus_tag="HJX77_27810"
     CDS             complement(4926..5105)
                     /locus_tag="HJX77_27810"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="QJN89788.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            5174..5551
                     /locus_tag="HJX77_27815"
     CDS             5174..5551
                     /locus_tag="HJX77_27815"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="entry exclusion protein 1"
                     /protein_id="QJN89789.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="entry exclusion protein 1"
     gene            complement(5613..5912)
                     /locus_tag="HJX77_27820"
     CDS             complement(5613..5912)
                     /locus_tag="HJX77_27820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="QJN89790.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(5902..6165)
                     /locus_tag="HJX77_27825"
     CDS             complement(5902..6165)
                     /locus_tag="HJX77_27825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid stabilization protein"
                     /protein_id="QJN89791.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="plasmid stabilization protein"
     gene            complement(6471..6890)
                     /gene="exc2"
                     /locus_tag="HJX77_27830"
     CDS             complement(6471..6890)
                     /gene="exc2"
                     /locus_tag="HJX77_27830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /protein_id="QJN89792.1"
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
                     /name="exc2"
     gene            7293..8978
                     /locus_tag="HJX77_27835"
     CDS             7293..8978
                     /locus_tag="HJX77_27835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="QJN89793.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="cloacin"
     gene            8988..9245
                     /locus_tag="HJX77_27840"
     CDS             8988..9245
                     /locus_tag="HJX77_27840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="QJN89794.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin"
     BGC             2293..9294
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          complement(289..867)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          3631..4358
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.32e-150"
ORIGIN
        1 atgaataccg gggtttttaa atacagggaa ggtatatgaa aaaggtaaag gttgtttttc
       61 tttttatatt gattttttca ggctttcttc tggtcgcatg tcaggcaaac tatatccggg
      121 atgttcaggg tggaacggtg gcaccatcgt cctcctctga actgacgggg atcgcggttc
      181 agtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tcttttgccc
      241 tgtaaacgaa aaaaccacct ggggaggtgg tttgatcgaa ggttaagtca gttggggaac
      301 tgcttaaccg tggtaactgg ctttcgcaga gcacagcaac caaatctgtc cttccagtgt
      361 agccggactt tggcgcacac ttcaagagca accgcgtgtt tagctaaaca aatcctctgc
      421 gaactcccag ttaccaatgg ctgctgccag tggcgttttg cgtgcttttc cgggttggac
      481 tcaagtgaac agttaccgga taaggcgcag cagtcgggct gaacgggggg ttcttgctta
      541 cagcccagct tggagcgaac gacctacacc gagccgagat accagagtgt gagctatgag
      601 aaagcgccac acttcccgca agggagaaag gcggaacagg tatccgggaa acggcagggt
      661 tggaacagga gagcgcaaga gggagcgatt catcggaaac ggtgatgatc tttaagtcct
      721 gtcgggtttc gccactcctg actgattcat ggttgagcca ccggctccca cagatgcacc
      781 gaaaaagcgt ctgtttatgt gaactcagtc aggagggcgg agcctatgga aaaacgccac
      841 ctgcgtggcc ttgccgtttt gcctcacatg ttagtcccct gcttattcac ggaatctgtg
      901 ggtaactttg catgtgtccg cagcgcccgc cgcagtctca cggccggagc gtagcgaccg
      961 agtgagcgag gaggcgcaat ttccccggca cctacaagac ggacaccgga cgcgctgatg
     1021 tggcatattg tcccctgatt aagtctttat attccctgat aataaattac caggataggt
     1081 gaatcatatc ggtttttcgc tgaacatttt acgttaacct atctctgttg cttttttctc
     1141 cttacggaga aatacaggtc atccccgcga gggcgtggct gacctcaggg ggatatcccc
     1201 tgcttacgct ggctggacgc caccgacgca cggtctctcc ccctctttct ggctccgtcc
     1261 ggctggacgc cggccacgcc agaaattcac ccggcccccg tcaggctcac gcctgaccac
     1321 ccacaaaaat ccacggtgct ggacgcacct ggcgaagcag caaagctgct cctgattttg
     1381 cgggtggtca gccgctcgct atggcgaact ctgacggggg ccggaacacc ggaaaagacc
     1441 gcactggggt gccgcctttt cctctcacac gctggggcgt gctcgttgtt cctccggggc
     1501 tgcgcctttt ccgcatgggg cggaaagagg ctggcctccg tggtgaaagc tgaacgcaat
     1561 caccacggac gtgaccgccg ccgccatgcc ttggggcatg tccgcggctt gtgcagcggg
     1621 ggctgcacat cacgccggca aaccatcgtc tgaaggagag agaacatgtt taatacggat
     1681 tcgcttgcct ggaagtggca cattccggag ctggcccggc agatttatcc gtgggtcagc
     1741 tggctgtacc aggagtatta cggtctggcc ggggctttcc tagttatcgg cctgtttttc
     1801 ggtctggctg aactttgggc cggacggatg cgttttgtgg ggctgagtca taaggagcga
     1861 cgggagtatg ccgatcgcta taagcgcgat aataaacggc cagcgccatt ttcggtgctg
     1921 gcctcgctgg attcgcccgg gcggatggtc agggcacgtc gacatgtctg gaactacgcg
     1981 tactggctga ccggcgcggc cggtctggcc cttctggggg ggctggttgt cgccgtgttt
     2041 atcgagagct ggggagaaac cgtcctgcgt ccggacctct acgcaaacgc agattattac
     2101 ctgctgcagc cggctaacct gttcgggatt gcctggtgcg cgggcgggct ggctgtcggg
     2161 attgtgttgg cgcggctgct ggcgttcctg ctgcttgacg gtcattttgc ggctgctgac
     2221 gaggcggtga acgcgaaact gaatcaggag agccggcgca gcagccagcg gacaggagag
     2281 atgaccgacg tgcgccacct gcatttcggg gagccggtac cggttaatgc gctggccgat
     2341 ttttcctcgg agcaggcccg gcaggagcag gcggtgtttc tgggtaagga tgagcagggc
     2401 aagccggtgc tggttccgcg tgatacctgg cgcaagacca acattcagat cctcggcctg
     2461 cccgggagcg gcaagagcgt gatggccacc aacgcgctca ttcgctgcgt acgcgatttc
     2521 ggggacgcgg tggtgtactt cgaccccaaa ggggacgcat gggcgccgca cgtcttccgg
     2581 gcgcactgtc cggacttcac cctgctggat ctgcggccgg ggaaaccggc gcagctgaat
     2641 ctgttccgcg atctcgacca gtacgcgctg aaaaacctgc tgattgccgg gcttaacctg
     2701 ggcgagaccg gcgacgtggc ggaccactac cgcatcagcg agcagaaagc ggcgaagctg
     2761 attgcggagc agtttccgca gggggcaaac attcagcagg tgctggcggc ggcgtacgcg
     2821 ctgccggagg ccctgaaaaa ggacgtgaag gggttgatca ctaggctgga aaacgtcgct
     2881 gacctgagcg tcctgcagac ggacagtggc atcgatgtgg cggggattat caacggcggc
     2941 ggctgcctgt acgttatcgg ctcgatggac gacgaggcgg tgatccgtgt gcaaaaaatg
     3001 ctgtttgccc gctgcgcgca aatcatcatt gcgcgggacg agttccggga gtggccacac
     3061 gtcagcgtga tgctcgatga aattaaatat ctgctgtcga agtatgtact gaacgcactg
     3121 gggacgctgc gcagccggga ctgcaatctg ttgctcgcgc accagtcgct gggcgatttc
     3181 gggcagtgcg ggcaggatct gcccgctgaa tttgtgaaaa ccacggtact ggataacacg
     3241 ccgatccgct ggttttaccg ggcggccagc ctggagtccg cgcagtgggc ggcggggcag
     3301 accggggaaa tcagggtgga cgtggagcgc cgccgtgcca gccgggaggc ggggaacgtg
     3361 gagcatatca gcggggacag cttcatccag aaggaggcgc ggccgctgtt tgacgtgaac
     3421 accctgcaac acctgccgga cgggttcgcg gtcatgaccg ggctgggtgt ggcccggatg
     3481 gcgttcagca gtccgctgcg ggttgagcgc cgggaaatcc cgttgcagcg tttcccggtg
     3541 ctggcgaaaa ccgatcccct ggcggagttc cggcccccgg ccgacggcgg cgggccgaaa
     3601 gcggatgatg attttgcggg gatttactga tggcgctgga gctgtacaac gtcagccacg
     3661 cgaaacgaca ggcgcggaac gcggagaaaa cccggctgac cctgcgctgg ttgcgggaag
     3721 agctgtgttc cacggcggag ctggttgcgc ggcggctggg gattgcggcg gtgcagccgg
     3781 tctaccgctt cctcgacagc ctggtggcga aagggctgct ggtccggacc aaatatccgg
     3841 tggacggccg tcaggtcagc gtgtgggggc tgacgccgca tggcgtggcg ttctcgttcg
     3901 acgaggacga accgctggcg gatgttattc cgtttcagcc gtcaagggtg tcggcagcac
     3961 atctgccgca ccggctggcc gtgcaatccc tgcgccttga tatggaagcc agaggggcca
     4021 ccggctggcg cattctgcac cgtctgagtc ttaaaggcat gaaagtgccg gacgccctgg
     4081 cggagctgga cggtaaaacg gtggcgtttg aggtggagcg caccgtcaag agccgtcgcc
     4141 ggtatcagga agtggtgtcc gggtatctgt tcaaccgcaa agctaacggc atcgatgaaa
     4201 tctggtacat ctgcccggac cgggcgacgc aggtcagggt gcagcgggca atcctgtcgg
     4261 tggatgaaat cgtgaaccca cagaccggcg aggcccgcaa aacggcagag ctggatcgtg
     4321 aacggttgtt tgcgtgcttt aaatttatga caacggagtg agggattatg gcgctgtaca
     4381 tggtatttat tgaagacgcg gaggaccgga acggcgagcg ctgcatcatg ccgaccagcg
     4441 agcatctgga agatatggtg gtgctcgcct ggcagaccgg ggcgtatgtt ttctgttttg
     4501 tcgaccgggc ccagcatctg gcgatgatga aatccatcgg gatgtatgac gagcggctca
     4561 acagcgacga aaaagccacg tactttttca ctggtaaaaa tccgcaatgg gaacggaaca
     4621 aacccacagg aatgaagctg tgtgattacc tctatcgcaa ggtggagcgg ttcgccatcg
     4681 agaacggtgt gcaggtggtt gatgccggga agtgctcacc ggagcagatt aacgcgatga
     4741 ttgacgtggt gagtgagcgg cacggggaaa gcgcggtgaa cgagaagctg aaagcggagc
     4801 tgatgcggga atataacagc cgctatttta acgtgccggt acctgaactg ccggaggaca
     4861 aacctgcccg ccggtggtgg ccgttcggca aaaaataaat gccagcaccg gccatgccgg
     4921 tgctgttatt cctccccgag cttatcccgc atcacctgcc agagtgtttc cgcatcctcg
     4981 tgtagccgct cgcacatgtc ggccggggta tccatatcca gctcattcag tttatcgagc
     5041 aatagcagcg actgctcctt aataaattta gccatattga gggctgtttt ttcctgtttt
     5101 gtcatgattc tttccttccg ggcatggtgt gcgcctgtca ggtatactgt ctcaaaaata
     5161 gcggggtgag acaatggcgt gggtgacggt gagacaggcg acggaactga cgggtaaagc
     5221 ccgaagttcc ctgtatcggg atatggcgaa aggccgcgta tcataccgta cggaagctga
     5281 tggcggccgg gtggtggata ccagcgagct tatccgggtg tacggtgagt taagacagga
     5341 tgagactcac gagcgggacg agttgagact gtcgggtgag actgaaaaaa tggcctccga
     5401 cgcgttgatc gcggagataa aagcactcag ggaggaggtg gccgggctac ggcaggaaat
     5461 gcagtccatg agactgctgg aacacaaacc ggagacagca gagaccccgg ccggaacacc
     5521 gcgccggtgg tggccgtggg gaaaacgctg acgcgctgtg cttgtccaac cggcgacggc
     5581 cacgcaatga attgcgtccc cgtcaccggt tattagagaa caatatgggg attctggcgc
     5641 tggccgacca cggccagaac ccggactttt ctggtctggt catcaacatc atagaggaca
     5701 tgctgtccca tcagactgat ccggcgaacg tcctcgccat agcgtgagtc cacttcatag
     5761 agtcgcggga agtcggccag tttgtccgcc gcagcgagaa cccggtcggt aacgttctgc
     5821 gcatcccaca gggatgaatt ttccgcgata tagtcaaaca gcgtcgttac atcctcgatg
     5881 gctccctgct tccattccac gtcatacggc atcgcgcagt tcctgataac ggccatgcag
     5941 gcgctggcgg agttgttccg tggtcatacc cggacgcgtg tcagcacggg cggcggtcac
     6001 tttggcgcga acctgatctt catactctgc ctgggccagt tcttcgttag ccagtcgctg
     6061 caacagcgca gctttgtccg ggccaccttc cggcagtatg cggggcaggc tttcagccag
     6121 ttcccgaaga aagttggcgt tttcgtagtg tgtagtgttg ctcattgcgg agcctcccgg
     6181 gttaatgcgg caatatgaag gaagtttagc agggggcggt ctgaaagaat atggtcgtgt
     6241 cagtcaggct gatgaagcag aaagtcggta aaaaagggct tacggcatcc attttacgtc
     6301 aaaacatatg ccatgcagtt gcgtgcatag gcatgcatta ggataaaatt tatcgggcgc
     6361 gtttccggca gttttccggg ggggttgttg cctgttttat cccgtagccg ccggaaacgc
     6421 cctgagcccg tctgagcggt gcgcgtaatg acgcgttatg gtaaatccac ttactgtctg
     6481 ccttcatagc catcgagata aacagctgaa atggtgtcag ccagtagcct tgattttttc
     6541 ggtgtgaggt ctttgctgcg gtaatcggta cccgcaaatt gtgttgtgcc ttggagtgag
     6601 tttaaaaatt cctgactgtg aaactgctga atgcgttgct gcacatcact ccgtgatttt
     6661 ccggtcgctt tatcctttgc gcccatatcc cagaactgcc ggaaaaaagg caccatcatt
     6721 cgtgttgtgt cagctttctg ggtggaaaaa ttgggatcaa aaccgtcatc tgaagcatat
     6781 acgtaatgcc gggtatgctg ttccacgctg ccctttggag cacaggcagt gagagttgct
     6841 gtcgctgtta tcatggcgat aagacacagt ttgctgccgg aacgtctcat gagcgtctcc
     6901 ttacctttaa ttcttttttc tcattgagtt atatatccgc aggctatctt atcatcagtt
     6961 tctgaccgtg ttcagtgacc gaacaacccg aaccagaccc cccgtttctt ttcctgtccc
     7021 ggagggggct ttctggtatc tcatataatg atttcagtaa aacatactga ggccggagaa
     7081 cggcgccgtt tgtgctggtt tttgttgcat ctggagggga ttgcgcatgg tgtgagtggc
     7141 tgtttttttg atcattttca caaaaacgca aatttacaga cttgacatga aaaacaaggc
     7201 agcgtaattt ttatactgta tataaaacca gtggttatat gtacagtatt ttattttagt
     7261 ttattgtttt aaaagtcaaa gaggaaaagt atatgagtgg cggagacgga cgaggtccgg
     7321 gtaattcagg tctgggacac aatggtggtc aggccagtgg gaatgtgaac ggtacatcag
     7381 gtaaaggtgg cccttcatca ggtggtggta cggatccaaa cagcgggccg ggctggggta
     7441 cgacgcatac acctaacggg gatattcata actataaccc gggggagttt ggtaacggcg
     7501 ggagtaaacc cggtggtaat ggcggtaaca gcggcaatca tagcgggagc tctggtggcg
     7561 gacagtcttc ggccaccgcg atggccttcg gtctgcctgc cctggccact ccgggggctg
     7621 aaggactggc tttatccgtt tccggcgatg cgttgtcggc cgctgttgct gatgtgctgg
     7681 ctgccctgaa aggtccgttt aagtttggtc tgtgggggat tgcgatttac ggagtgctgc
     7741 cttctgagat agcaaaagat gatccgaaaa tgatgtcaaa aatcgtgacg tcattgccgg
     7801 cagacacggt aacggagacg ccggtcagct ccctgccgct ggaccaggcg acggtcagcg
     7861 tcactaaacg tgtggcggat attgtgaagg acgagcggca gcatattgcg gttgtcaccg
     7921 gccggccaat gagtgttcct gtggtggatg cgaaaccgac aaaacgtccg ggggtattca
     7981 gtgtgtcgat tccgggtctc ccgtctctgc aggtgagcgt acctaaaggt gttccggccg
     8041 cgaaagcccc gccaaaaggc attattgctg aaaaaggtga ttcacgtccg gctggtttta
     8101 cggccggtgg taactcccgt gaggccgtta ttcgtttccc gaaagagagc ggacagaaac
     8161 cggtctatgt gtcggtgacg gatgttctta ctccggcaca ggtaaaacag cgtctggagg
     8221 aagaaaagcg tcgccagcag gcatgggacg ctgctcaccc ggaagagggg ctgaaaagag
     8281 agtatgataa agcgaaagct gagctggatg ctgaagataa aaatattgcg accttaaaca
     8341 gtcgcattgc atcgacagag aaggcgatcc ccggtgcaag ggctgctgtt caggaagccg
     8401 ataaaaaggt aaaagaggca gaggcaaata aagatgattt tgtgacttat aacccgcctc
     8461 atgaatatgg ctccgggtgg caggatcagg ttcgctatct tgataaggat attcagaatc
     8521 agaatgagaa attaaaagct gcccagacat ctttaaacga aatgaatgaa tccttatcca
     8581 gggataaggc tgcgctttcc ggggcgatgg agagccggaa acaaaaggag aaaaaagcga
     8641 aggatgcaga aaataaatta aatgaggaaa agaaaaaacc tcgtaaggga actaaagatt
     8701 acggccatga ttattttcct gatcccaaga ctgaagatat taaggggttg ggagagttga
     8761 aagagggtaa acctaaaacc cctaaacaag gtggtggtgg taagcgggcc cgatggtatg
     8821 gtgataaaaa gcgtaaaatt tatgaatggg attcccagca cggtgagctt gaagggtacc
     8881 gcgccagtga tggcgaacac ctcggggcat tcgatccaaa aacgggtaag caggttaaag
     8941 ggccggatcc aaaacgaaac attaaaaaat atctttaaga ggtaaatatg gggcttaaat
     9001 tacatattca ttggtttgat aagaaaaccg aagagtttaa aggtggtgaa tactcaaaag
     9061 acttcggtga tgatggttct gtcattgaaa gtctggggat gcctttaaag gataatatta
     9121 ataatggttg gtttgatgtt gaaaaatcat gggtttcgat attacagcca cactttaaaa
     9181 atgtaatcga tattagtaaa tttgattact ttgtatcctt tgtttaccgg gatggtaact
     9241 ggtaagcaaa agttatcaag gatgatttga aatacagact tccggtgttc aggg
//
