LOCUS       CP052030               25430 bp    DNA     circular BCT 24-SEP-2020
DEFINITION  Staphylococcus aureus strain ER09772.3 plasmid pER09772.3A.1,
            complete sequence.
ACCESSION   CP052030
VERSION     CP052030.1
DBLINK      BioProject: PRJNA470993
            BioSample: SAMN14669413
KEYWORDS    .
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 25430)
  AUTHORS   Caban,A.B., Pak,T., Kumaresh,A., Dupper,A., Chacko,K.,
            Sullivan,M.J., Altman,D.R. and van Bakel,H.
  TITLE     PathoSPOT genomic surveillance reveals prolonged under the radar
            outbreaks of nosocomial methicillin resistant S. aureus bloodstream
            infections
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 25430)
  AUTHORS   Caban,A.B., Pak,T., Kumaresh,A., Dupper,A., Chacko,K.,
            Sullivan,M.J., Altman,D.R. and van Bakel,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2020) Genetics and Genomic Sciences, Icahn School
            of Medicine, One Gustave L. Levy Place Box 1498, New York, NY 10029,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 230.929793239684x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/24/2020 08:52:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 3,042
            CDSs (total)                      :: 2,963
            Genes (coding)                    :: 2,776
            CDSs (with protein)               :: 2,776
            Genes (RNA)                       :: 79
            rRNAs                             :: 6, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 187
            CDSs (without protein)            :: 187
            Pseudo Genes (ambiguous residues) :: 0 of 187
            Pseudo Genes (frameshifted)       :: 158 of 187
            Pseudo Genes (incomplete)         :: 23 of 187
            Pseudo Genes (internal stop)      :: 18 of 187
            Pseudo Genes (multiple problems)  :: 12 of 187
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..25430
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="ER09772.3"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pER09772.3A.1"
                     /geo_loc_name="USA:New York City"
                     /lat_lon="40.7903114 N 73.9528738 W"
                     /collection_date="2017"
                     /collected_by="Mount Sinai Hospital"
     gene            join(24758..25430,1..2)
                     /locus_tag="HIK73_13645"
     CDS             join(24758..25430,1..2)
                     /locus_tag="HIK73_13645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="QOB25980.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            143..778
                     /locus_tag="HIK73_13650"
                     /pseudo=""
     CDS             143..778
                     /locus_tag="HIK73_13650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032491779.1"
                     /note="internal stop; incomplete; partial on complete
                     genome; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside 6-adenylyltransferase"
                     /name="aminoglycoside 6-adenylyltransferase"
     gene            775..1305
                     /gene="sat4"
                     /locus_tag="HIK73_13655"
     ARG             776..1302
                     /name="sat4"
                     /gene="sat4"
                     /gene_name="streptothricin N-acetyltransferase Sat4"
                     /tool="amrfinderplus"
                     /drug_class="STREPTOTHRICIN"
                     /identity="97.78"
                     /coverage="100.0"
     gene            1398..2192
                     /gene="aph(3')-IIIa"
                     /locus_tag="HIK73_13660"
     ARG             1399..2189
                     /name="aph(3')-IIIa"
                     /gene="aph(3')-IIIa"
                     /gene_name="aminoglycoside O-phosphotransferase
                     APH(3')-IIIa"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(2300..2488)
                     /locus_tag="HIK73_13665"
                     /pseudo=""
     CDS             complement(2300..2488)
                     /locus_tag="HIK73_13665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002913594.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            2468..3039
                     /locus_tag="HIK73_13670"
                     /pseudo=""
     CDS             2468..3039
                     /locus_tag="HIK73_13670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001079940.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="HTH domain-containing protein"
                     /name="HTH domain-containing protein"
     gene            complement(3208..3882)
                     /locus_tag="HIK73_13675"
     CDS             complement(3208..3882)
                     /locus_tag="HIK73_13675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="QOB25961.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            4144..4329
                     /locus_tag="HIK73_13680"
     CDS             4144..4329
                     /locus_tag="HIK73_13680"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOB25962.1"
                     /translation="MNKLEKWSLVFIIFTFLSSLALLYFKYNFSSVMPVLSLSILTILI
                     LLTSIITVVSVNDEDT"
                     /name="hypothetical protein"
     gene            complement(4552..5130)
                     /locus_tag="HIK73_13685"
     CDS             complement(4552..5130)
                     /locus_tag="HIK73_13685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="QOB25963.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNKQDLNLLKTLYDNGTPI
                     KTIAEQWQVSRTTIYRYLNKLEAKENKNK"
                     /name="recombinase family protein"
     gene            complement(5394..5774)
                     /gene="blaI"
                     /locus_tag="HIK73_13690"
     ARG             complement(5398..5774)
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.21"
                     /coverage="100.0"
     gene            complement(5764..7521)
                     /gene="blaR1"
                     /locus_tag="HIK73_13695"
     ARG             complement(5768..7521)
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="98.8"
                     /coverage="100.0"
     gene            7628..8473
                     /gene="blaZ"
                     /locus_tag="HIK73_13700"
     ARG             7629..8470
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.29"
                     /coverage="100.0"
     gene            complement(8987..9406)
                     /locus_tag="HIK73_13705"
     CDS             complement(8987..9406)
                     /locus_tag="HIK73_13705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418035.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="QOB25967.1"
                     /translation="MELDNCINYLLSTSQNRVFKHFKSLLSPYNITPAEYGVLNCLINS
                     NLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRTVLINSTNKAKDLWPTL
                     EKKAYQLNNHYFANLTNEETVVFKKILLKINKTTF"
                     /name="MarR family transcriptional regulator"
     gene            9530..10501
                     /locus_tag="HIK73_13710"
     CDS             9530..10501
                     /locus_tag="HIK73_13710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="QOB25968.1"
                     /translation="MFNAVVVRKSASNVSYKVEKVDESHLSKGDVLVKVVYSSINYKDM
                     LALQYKGGVIRDYPMIPGIDFAGIVESSSNDKFKEGDNVLVTGYDVGVTHTGGFSEYAQ
                     VPGEWIVPIPQEMSIKESMVYGTAGFTAALSIFELEKYGMNIKSQPEILVSGATGGVGS
                     VAIQILHKIGYENITAIVRKEKQIEIAKKLGAKQVIIIEDDNKPLKKGIFDYFLDTVGS
                     NVTLYGLKRLNYQGVATVCGNVAGNSLNANILPFILRGIKLIGIDSVYVDHNIREDIWS
                     KLANEWNIGNSLLYNEIGFEEFYKTIDQLLKGQHLGRTILKV"
                     /name="oxidoreductase"
     gene            complement(10673..10765)
                     /locus_tag="HIK73_13715"
     CDS             complement(10673..10765)
                     /locus_tag="HIK73_13715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="QOB25969.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(10922..11269)
                     /locus_tag="HIK73_13720"
     CDS             complement(10922..11269)
                     /locus_tag="HIK73_13720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="QOB25970.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNHEGF"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(11288..11905)
                     /gene="cadD"
                     /locus_tag="HIK73_13725"
     ARG             complement(11292..11905)
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(13024..13218)
                     /locus_tag="HIK73_13730"
     CDS             complement(13024..13218)
                     /locus_tag="HIK73_13730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001004925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOB25972.1"
                     /translation="MNENLEKYIKSLPLLGLLISILLIVLFFFILDVDEDLFVVFLYCL
                     LPLIVNLSIYGFYVFVKRK"
                     /name="hypothetical protein"
     gene            13328..14019
                     /locus_tag="HIK73_13735"
                     /pseudo=""
     CDS             13328..14019
                     /locus_tag="HIK73_13735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691527.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            complement(14187..14336)
                     /locus_tag="HIK73_13740"
     CDS             complement(14187..14336)
                     /locus_tag="HIK73_13740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000695367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOB25973.1"
                     /translation="MKIKTFATFTHRQLDKQVNRFLKNDIHVLEIQTHSNWLYISAIVF
                     YEDK"
                     /name="hypothetical protein"
     gene            complement(14883..15199)
                     /locus_tag="HIK73_13745"
                     /pseudo=""
     CDS             complement(14883..15199)
                     /locus_tag="HIK73_13745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002483623.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            complement(15192..16175)
                     /locus_tag="HIK73_13750"
     CDS             complement(15192..16175)
                     /locus_tag="HIK73_13750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="QOB25974.1"
                     /translation="MQNQYFTVQENYKERFYQIPKVFFTSENYKNLTNDMKIAYAILRD
                     RLNLSIKNSWVDEDGNIYFVYSNEKLMEILNCKKEKLTKIKKGLENDGLLIQKRRGLNK
                     PNILYLMKPIVTERDIYKIEKEENDVEPYGEKEVRKSNVQKFENRTSRSSKIERPEVRK
                     SNTNDTDFNDIDFNDTENNDMNDLNDIKYKNEISNHSNHSNQFTHNFDDKEMLLQEFPE
                     QLTNYLLKYDYRDLEIIKAVILKAKKSFNSRHEDMHYMLEDIEDEILTSLKRLKKAIHD
                     RGVKGQKETIKSMQAYLMQTILTELEETHALYMRRKNMKQYNIFNQ"
                     /name="replication initiator protein A"
     gene            16601..17343
                     /locus_tag="HIK73_13755"
                     /pseudo=""
     CDS             16601..17343
                     /locus_tag="HIK73_13755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843735.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /name="DUF536 domain-containing protein"
     gene            complement(17812..18711)
                     /gene="mph(C)"
                     /locus_tag="HIK73_13760"
     ARG             complement(17816..18711)
                     /name="mph(C)"
                     /gene="mph(C)"
                     /gene_name="Mph(C) family macrolide 2'-phosphotransferase"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(18810..20275)
                     /gene="msr(A)"
                     /locus_tag="HIK73_13765"
                     /pseudo=""
     ARG             complement(18814..20162)
                     /name="msr(A)"
                     /gene="msr(A)"
                     /gene_name="ABC-F type ribosomal protection protein Msr(A)"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE/STREPTOGRAMIN"
                     /identity="100.0"
                     /coverage="92.21"
     gene            20749..21423
                     /locus_tag="HIK73_13770"
     CDS             20749..21423
                     /locus_tag="HIK73_13770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="QOB25976.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            21481..21858
                     /locus_tag="HIK73_13775"
                     /pseudo=""
     CDS             21481..21858
                     /locus_tag="HIK73_13775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000866106.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /name="response regulator transcription factor"
     gene            21855..22736
                     /locus_tag="HIK73_13780"
                     /pseudo=""
     CDS             21855..22736
                     /locus_tag="HIK73_13780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_501406.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /name="HAMP domain-containing histidine kinase"
     gene            22852..23781
                     /locus_tag="HIK73_13785"
     CDS             22852..23781
                     /locus_tag="HIK73_13785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000074567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="QOB25977.1"
                     /translation="MKNLNNIIEINNLTKQYGSQIAVNNLSITVESGQIYGFLGRNGAG
                     KTTTIRMLLGLIKPTKGNIKIFEKEFESNKTEILKNIGAMVETPGFYSNLTAKENLTIN
                     AKILGIQKENAIEEVLEIVGLASEKVKLFKNYSLGMKQRLGIARALLHNPELLILDEPT
                     NGLDPIGIKEIRKLIKDLAQSRNITILISSHILSEIEQLVDKVGIIHNGVLLEEIMYED
                     LKKKNRQFISISVSDEEKVACLLETNFGIYDYKIKENGEFKIYSHIDRQQEINRLLVLN
                     NIDVFQMRVIEDNLETYFEDLVGGGTIG"
                     /name="ABC transporter ATP-binding protein"
     gene            23774..24511
                     /locus_tag="HIK73_13790"
     CDS             23774..24511
                     /locus_tag="HIK73_13790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000369394.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="QOB25978.1"
                     /translation="MDNLLRTEFIKLKRSYMFLISILGTCVAPFMVVVASFISMRTKVP
                     TPNIVFKQLFEEVSLYHMLIIGPPLYGVIIAYLFGREYIEDTLKNLLIIPISRESFLVS
                     KIILLFLWIQTLSVIAWLLTLMLGMLLHFQGLSQSLIIDSFFTFVIGGVLLWILSPPII
                     ILSIYFKNYVPTIVLTIIITLINLMTANSEHRGLFPWAAVGDISRGTLPNTYPFLLSLI
                     IIIVTSIFSVIILFSYFKKTDIS"
                     /name="ABC transporter permease"
     gene            24525..24728
                     /locus_tag="HIK73_13795"
     CDS             24525..24728
                     /locus_tag="HIK73_13795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001627151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP kinase"
                     /protein_id="QOB25979.1"
                     /translation="MGFIEQIKAFILGVVEGLTEFAPVSSTGHMIIVDDMWLNTADDLG
                     SASATTFKVVIQLGGSVAKLNL"
                     /name="UDP kinase"
     ARG             complement(20133..20275)
                     /name="msrA"
                     /gene="msrA"
                     /gene_name="msr-type ABC-F protein"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; streptogramin
                     antibiotic; streptogramin B antibiotic"
                     /identity="97.37"
                     /coverage="9.63"
     ARG             complement(18811..20129)
                     /name="msrA"
                     /gene="msrA"
                     /gene_name="msr-type ABC-F protein"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; streptogramin
                     antibiotic; streptogramin B antibiotic"
                     /identity="98.41"
                     /coverage="89.96"
     ARG             complement(17813..18711)
                     /name="mphC"
                     /gene="mphC"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="98.66"
                     /coverage="100.0"
     ARG             788..1305
                     /name="SAT-4"
                     /gene="SAT-4"
                     /gene_name="streptothricin acetyltransferase (SAT)"
                     /tool="rgi"
                     /drug_class="nucleoside antibiotic"
                     /identity="97.16"
                     /coverage="95.56"
     ARG             180..481
                     /name="aad(6)"
                     /gene="aad(6)"
                     /gene_name="ANT(6)"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="99.0"
                     /coverage="36.23"
     ARG             7629..8473
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="95.37"
                     /coverage="100.0"
     Typing          complement(14680..14827)
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="5.980000000000001e-72"
     Typing          complement(14886..15061)
                     /name="rep_cluster_1017"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="92.697"
                     /coverage="94.0"
                     /evalue="1.04e-65"
     Typing          complement(15193..16175)
                     /name="rep_cluster_2100"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.593"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          16602..17343
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.866"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 aaacgaacac tgacatgata tattagtgat tagctatatt ttttactttg caacagaacc
       61 atcattttta ttaaaatact cttttgtaaa atctttctgc tcttcaatgt atttaatttc
      121 tttacctcta aatctattat agctatttga tgattacaat aaaattgatc ttaccttatt
      181 gcccttggaa gagttagata attacctaaa gggcgataaa ttaataaagg ttctaattga
      241 taaagattgt agaattaaaa gggacatagt tccgactgat atagattatc atgtaagaaa
      301 gccaagcgca agggagtatg atgattgctg caatgaattt tggaatgtaa caccttatgt
      361 tattaaagga ttgtgccgta aggaaatttt atttgctatt gatcatttta atcagattgt
      421 tcgccatgag ctgctgagaa tgatatcatg gaaggtcggc atcgaaacag gctttaaatg
      481 aagtgtaggc aagaactata agtttattga aaggtatata tccgaggatt tgtgggagaa
      541 acttttgtcc acctaccgga tggattccta tgaaaacata tgggaagcat tatttctatg
      601 ccatcaattg ttcagggcgg tatccggtga ggtggcggaa aggcttcatt atgcctatcc
      661 ggagtatgat aggaatataa caaaatatac cagggacatg tataaaaaat acactggtaa
      721 aaccggctgc ctggatagca catatgccgc tgatatagaa gagaggcggg aacagtgatt
      781 acagaaatga aagcagggca cctgaaagat atcgataaac ccagcgaacc atttgaggtg
      841 ataggtaaga ttataccgag gtatgaaaac gagaattgga cctttacaga attactctat
      901 gaagcgccat atttaaaaag ctaccaagac gaagaggatg aagaggatga ggaggcagat
      961 tgccttgaat atattgacaa tactgataag ataatatatc tttactacca agacgataaa
     1021 tgcgtcggaa aagttaaact gcgaaaaaat tggaaccggt acgcttatat agaagatatc
     1081 gccgtatgta aggatttcag ggggcaaggc ataggcagcg cgcttatcaa tatatctata
     1141 gaatgggcaa agcataaaaa cttgcatgga ctaatgcttg aaacccagga caataacctt
     1201 atagcttgta aattctatca taattgtggt ttcaaaatcg gctccgtcga tactatgtta
     1261 tacgccaact ttgaaaaagc tgttttctgg tatttaaggt tttagaatgc aaggaacagt
     1321 gaattggagt tcgtcttgtt ataattagct tcttggggta tctttaaata ctgtagaaaa
     1381 gaggaaggaa ataataaatg gctaaaatga gaatatcacc ggaattgaaa aaactgatcg
     1441 aaaaataccg ctgcgtaaaa gatacggaag gaatgtctcc tgctaaggta tataagctgg
     1501 tgggagaaaa tgaaaaccta tatttaaaaa tgacggacag ccggtataaa gggaccacct
     1561 atgatgtgga acgggaaaag gacatgatgc tatggctgga aggaaagctg cctgttccaa
     1621 aggtcctgca ctttgaacgg catgatggct ggagcaatct gctcatgagt gaggccgatg
     1681 gcgtcctttg ctcggaagag tatgaagatg aacaaagccc tgaaaagatt atcgagctgt
     1741 atgcggagtg catcaggctc tttcactcca tcgacatatc ggattgtccc tatacgaata
     1801 gcttagacag ccgcttagcc gaattggatt acttactgaa taacgatctg gccgatgtgg
     1861 attgcgaaaa ctgggaagaa gacactccat ttaaagatcc gcgcgagctg tatgattttt
     1921 taaagacgga aaagcccgaa gaggaacttg tcttttccca cggcgacctg ggagacagca
     1981 acatctttgt gaaagatggc aaagtaagtg gctttattga tcttgggaga agcggcaggg
     2041 cggacaagtg gtatgacatt gccttctgcg tccggtcgat cagggaggat atcggggaag
     2101 aacagtatgt cgagctattt tttgacttac tggggatcaa gcctgattgg gagaaaataa
     2161 aatattatat tttactggat gaattgtttt agtacctaga tttagatgtc taaaaagctt
     2221 taactacaag ctttttagac atctaatctt ttctgaagta catccgcaac tgtccatact
     2281 ctgatgtttt atatcttttc taaaagttcg ctagatagag ttctatatta gagatgtaaa
     2341 gagttttggt gaagaggttt gtgagtatgg cttttataac cagggtgcaa tgagaagcac
     2401 taacagcagc tagcttaaga acgcatagga tatacttttt atggaagtca cagaggagga
     2461 ataaaatttg aacaggatta acagagtaac ctctattctt attcagctgc aatcaaaaaa
     2521 ataattcctg ccaaagaaat tgcacagcga tttaatataa gcttaaggac agtttacaga
     2581 gatatccgga cacttgaaga agccggaata ccaattggat ctgaggccgg aaaaggatat
     2641 tttcttgtag agggcttcct acttccgccg gtaatgttta cagcggcgga agtgggtgca
     2701 ttgattacag cagggaaatt tttaaattgc catggagatg aatcatttat aaaggatttt
     2761 gattcagcta tgtataaaat caaatctatt ttgaagcatg gtgaaaaaaa ctatgcacag
     2821 gagttggaga acagtattaa cgtgtacagc acatctggac agaaaaatac attggcggat
     2881 aacgttattg cagcaattca gactgcaatc tgcaataaaa gggtaatatc aattcaatat
     2941 cctgcatcag gagggcaaga accggaaagc agaatgatag agcctatatc actggggttt
     3001 tatgaacaga actggtactt aatcggtttt gcaggctaag aaatgaatat aggaattttc
     3061 gtgtggatcg gattaaaagc atttgcatag aagaagagct ctgtcaaagc catgatggct
     3121 ctttggaaca aatattaaaa caaatgctgg ttctgttgca aagtaaaaaa atatagctaa
     3181 ccactaattt atcatgtcag tgttcgctta acttgctagc atgatgctaa tttcgtggca
     3241 tggcgaaaat ccgtagatct gaagagacct gcggttcttt ttatatagag cgtaaataca
     3301 ctcaatacct tttaaagtat tctttgctgt attgatactt tgataccttg tctttcttac
     3361 tttaatatga cggtgatctt gctcaatgag gttattcaga tatttcgatg tacaatggca
     3421 gtcaggttta agtttaaaag ctttaattac tttaaccatt gctaccttcg ttgaaggtgc
     3481 ctgatctgta attacctttt gaggtttacc aaattgttta atgagacgtt tgataaacgc
     3541 atatgctgaa tgattatctc gttgcttacg caaccaaata tctaatgtat gtccctctgc
     3601 atcaatggca cgatataaat agctccattt tccttttatt ttgatgtacg tctcatcaat
     3661 acgccatttg taataagctt ttttatgctt tttcttccaa atttgatata aaattggggc
     3721 atattcttga acccaacggt agaccgttga atgatgaacg tttacaccac gttcccttaa
     3781 tatttcagat atatcacgat aactcaatgc atatcttaga tagtagccaa cagctacagt
     3841 gataacatcc ttgttaaatt gtttatatct gaaatagttc atacagaaga ctcctttttg
     3901 ttaaaattat actataaatt caactttgca acagaacctc atttactata tgggcatctc
     3961 tttcattatt aatacaaagc tttgtatctc cgatattagg caaaggtgta aacgaattag
     4021 gtgatactat aggattcaac attatattaa tcgtttcttt aataatgatt atcttcttat
     4081 tttttataaa tcgtagtaaa aatatctcct atgattatat aaaagttcaa agaggtgaag
     4141 ccaatgaata aattagaaaa atggtctttg gtatttatta tttttacatt tctctcttca
     4201 ttagcacttt tatatttcaa atataatttt agttcggtta tgccagtcct aagtctttct
     4261 attttaacta tactaatatt gttgacgagt attattactg tagtttcagt taatgatgaa
     4321 gatacttaaa acgttcatta gtgaaacagg tattatatta aaaaagcgta cgaatttgta
     4381 cgcttttttc ttgtgttatt attaaaatct cataacagga aaatattatg agattttaga
     4441 cgctgtcaga acgtctcttt tacatcgagt gacattgaat caaagtcttt gtatgttaat
     4501 gatatataaa attatttagt agattcatta tagtaagcta gattagttgc tctacttgtt
     4561 tttattctct tttgcctcta atttattgag ataacgataa atagttgtac gtgaaacttg
     4621 ccactgctct gcaattgttt taattggcgt accattatca taaagtgtct taagtaagtt
     4681 taaatcttgt ttatttaatt tttcaggtct acctccatat cggcctctag cacgtgctgc
     4741 aattcgaccg gctgatgatc gctctaaaat taaattacgt tcaaactctg caaatgctgc
     4801 gaataaatga aataataatt gtcctgtaga acttgattta tccatcgtta tattttcttc
     4861 taaactatga aaactcacac ctcgttcgtt aagttcatta actaacgtga ttaaatcctc
     4921 catgttccgt cctagtctat ctaatctcca aacaacaatc gtatctcctg acctcgcaaa
     4981 ttcaattgct ttatctaaac caggtcgctt actttttgaa ccactcatat ggtcattaaa
     5041 tatcttttca caaccatatg tatttaatcg atcctcctgt aaattcaaat tttgtaatcc
     5101 agttgaaact cttgcataac ctattttcaa aatacagacc tcctatatac acctttagtg
     5161 taccataact tgattacgag gtcttttgtg aacatagatt ttttgttggg tttttgaaca
     5221 cataattcta tgtaatacat acttatttag acataaaaag agagtgtaca gaaaatggtt
     5281 attttatgta cactctcatc tttactaata tattttaaat gttattaaca aaactaattt
     5341 aataagagtc aagtatagtt tacatatgta taatgtttga aacatatctc taattacttt
     5401 ttactaatat catttaaaat gtctcgcaat tcttcaattt ctttgttatt taattcttca
     5461 tttttcgcaa aatttagcac taaacttttc atgtcccctc catacagttt attaagaaaa
     5521 gttttagcag ttttcatttt aatatcgtct tctttaatat ttgatgagta aaaataaata
     5581 ttctctgatt tgtatcgttt tataatctct tttttatata gtcttgtgat taatgttcta
     5641 attgttttat cgctaacttc tttatatttt tgaatttcaa ctacaatttc attagctgat
     5701 actgattttt tatcccatat tatattcata acatcccatt cagccataga tatttcaact
     5761 tgcttattgg ccatttaaaa cacccatttc ttttaatatt ttttcactga ttaattcagc
     5821 atttttccca gacgggtttc catctgataa atgtgtagca aaataatact tatcatgatt
     5881 tgtaattacg taacctacaa accacccatt attatacttc ccgtttacta tacctgtacc
     5941 tgttttccca tacagttcat acttttcatt tttcttaatc aataatgaag aagataattg
     6001 attctttgct tttttactaa aatggttatt ttgttccatc atatttttaa aaactattac
     6061 ttgttcaaga ttagatattt tcaaactatc ttccatccaa tagtttttat aacttcccaa
     6121 attttcatta ccataattta attgcttgag ttgagccgca gtatagttct ttggtatttg
     6181 attactaata cgttcgaagt accaattaac tgaattttgc attgctgtat ttaaatcttg
     6241 ttccttattc caagactcga aaggataatg tttatgattc catgacatac gtgaattttt
     6301 atcacttatg atatgacggt caagtccaaa catcgctaaa taaattttat aagttgaatc
     6361 aggagaatat ctttttctac tttctttttc attataaata tagtatttgt ctttcttcat
     6421 gctgtacatg acgaaagatc cactatttga accaaaattt ttactttcat ctaaaatttg
     6481 gtgatcgttc tgtaagggct ttttataatt ataatcagtt atggattgcc ccatcaaaaa
     6541 ctggctttga attactatga gcaaaaaagt aaaaatacaa ataaaaattg gaattaattt
     6601 agactgtttt ttcaaattgg cttcttttat attaattaat cttcttttga gtaatgactt
     6661 tttaccatta aatgaatggc ttaatatatt tttattaaaa aatggaatat ttaatacgga
     6721 gtccataata gattccgcat aagttttaaa ttcatttttg ttaatattat taagaacaaa
     6781 tctatcagct tctacttcat tgtcatgaat tatctttctt tttacaatat gtattaatgg
     6841 attgtaactc ataacaatag agaagatatt aaagataatt aaatgtaaag tatctctatt
     6901 tttagcatga gcatattcat gcagtattat atattttagt cttttatcaa ttacactttt
     6961 aaaatatgaa ctaggaatca aaataatata tttcccatac caaaaagtta ttggagattg
     7021 aatagcctct gcttttcgaa tcacaatatt ttttttatat tgatggttga aaagtatcgt
     7081 atctatttta tttttttcat tttcgtttag ataaagtgac tgtttcttta aatatttaag
     7141 atataataag gctttcaaaa atttaaaact taaaataata actaaaacta tccaaataac
     7201 tgtgcagata ttatcaattg aatcccaatt aaacttatgg atatctgttg tgaactcttg
     7261 aataggtttg gtggtattta tgttatggtt caaatcgtgt gacttacttt caactgtggg
     7321 cgcttgatta ttcacattat taaattttat aaaagagaat ttaattggga taaaaggaat
     7381 taatccagca agcatagtta gataccaaac tttataattt aaactataat taaaatagcg
     7441 ttttaatatg tacctaaaaa atactaacaa tagaaatata aaacaaaagc ttactacgct
     7501 cattattagt aatttagcca ttttgacacc ttctttcaaa tatttataat aaacaattga
     7561 catcaatatt acaattgtaa tattattgat ttataaaaat tacaactgta atatcggagg
     7621 gtttattttg aaaaagttaa tatttttaat tgtaattgct ttagttttaa gtgcatgtaa
     7681 ttcaaacagt tcacatgcca aagagttaaa tgatttagaa aaaaaatata atgctcatat
     7741 tggtgtttat gctttagata ctaaaagtgg taaggaagta aaatttaatt cagataagag
     7801 atttgcctat gcttcgactt caaaagcgat aaatagtgct attttgttag aacaagtacc
     7861 ttataataag ttaaataaaa aaatacatat taacaaagat gatatagttg cttattctcc
     7921 tattttagaa aaatatgtag gaaaagatat cactttaaaa gaacttattg aggcttcaat
     7981 ggcatatagt gataatacag caaacaataa aattataaaa gagatcggtg ggatcaaaaa
     8041 agttaaacaa cgtctaaaag gactaggaga taaagtaaca aatccagtta gatatgagat
     8101 agaattaaat tattattcac caaagagcaa aaaagatact tcaacacctg ctgctttcgg
     8161 taagacttta aataaactta tcgcaaatgg aaaattaagc aaagaaaaca aaaaattctt
     8221 acttgattta atgttaaata ataaaagcgg agatacttta attaaagacg gtgtttcaaa
     8281 agactgtaag gttgctgata aaagtggtca agcaataaca tatgcttcta gaaatgatgt
     8341 tgcttttgtt tatcctaagg gccaatctga acctattgtt ttagtcattt ttacgaataa
     8401 agacaataaa agtgataagc caaatgataa gttgataagt gaaaccgcca agagtgtaat
     8461 gaaggaattt taatattcta aatgcataat aaatactgat atcatcttat agtttgtatt
     8521 atcgttgaca tgtataattt tgatatcaaa aactgatttt ccctctatta ttttcgatat
     8581 ttattttctt aattctcttt aacaaactag aaatattgta tatacaaaaa atcataaata
     8641 atagatgaat agtttaatta taggtattca tcaatcgaaa aagcaacgta tcttatttaa
     8701 agtgcgttgc ttttttctca tttataaggt taaataattc tcatatatca agcaaagtga
     8761 caatagcatt ttacaagtat tttttattgt tcgattaggg taaacctaaa taatacataa
     8821 attatattac aatatgttta ttatagaggc taaagtatct tagaaatttg gatagtaggt
     8881 ttttcgggaa taaaagtata gttggcttta atatataatt aagctaagct atcatttata
     8941 tttactcgat tataattcgc acttcaactt ttttataacg taaaaattaa aacgtagttt
     9001 tatttatctt tagtaatatc tttttaaaca ctacagtttc ttcattagtt aaattagcga
     9061 agtaatgatt attaagttga taggctttct tttctaatgt tggccataag tcttttgctt
     9121 tatttgtact gtttattagc acagttcttc tattttcatt atcagtttga cgtgttatta
     9181 gatccttttt ggacatctta tctaatattc cagatattgt tgaaggttct aaatttaaag
     9241 tattaccaat cgctttaggt gtattcaaat tactattaat caagcaattc aaaacaccat
     9301 attctgctgg agtaatatta tagggactta ataaactttt aaaatgttta aaaactctat
     9361 tctgagaagt actcaacaaa taatttatac aattatctaa ttccacaact aaaacctctc
     9421 ttaaatcatt agtattgact cgcttatcat atcatgataa gttttgtagg aaaatagttt
     9481 tgcaacaaaa acatacttct acaaaacaat tgtgaaagaa ggctaataaa tgttcaatgc
     9541 ggtagtagtg agaaaaagtg catcaaatgt tagttataaa gtagaaaaag ttgatgaatc
     9601 tcatttatcg aagggtgatg tattagtaaa agtggtatac tcttcaataa attataagga
     9661 tatgctagct ttacaatata aaggcggtgt aattagagat tatcctatga ttcctggtat
     9721 agattttgca ggtattgttg aatcaagttc gaatgataag tttaaagaag gcgataatgt
     9781 attagttact ggttatgatg ttggcgtgac acatacaggt ggattttcag aatatgcaca
     9841 agtgcctgga gagtggattg ttcctattcc ccaagaaatg tctattaaag agtctatggt
     9901 atatggcaca gccggtttta cggcagcatt atcaattttt gaactagaaa aatatggaat
     9961 gaatatcaaa tcacaacctg aaattttagt gtctggggct acaggtggtg tgggcagtgt
    10021 tgctatacaa attttacata aaattggata tgaaaatatc actgctatcg taagaaaaga
    10081 aaagcaaata gaaatcgcaa aaaaattagg tgcaaaacaa gtaataataa ttgaagatga
    10141 taataaaccg cttaaaaaag gtatttttga ttatttctta gatacagtgg ggagtaatgt
    10201 aacattatac ggtttaaaac gtctaaatta tcaaggtgtt gctactgtat gtggaaatgt
    10261 agcaggaaat tcacttaacg ctaatatatt accgtttatt cttagaggta ttaaattaat
    10321 tggcattgat tctgtatatg ttgatcataa tatccgtgaa gatatatgga gtaagttagc
    10381 aaatgaatgg aatataggaa attcacttct atacaatgaa attggatttg aagaattcta
    10441 taaaacgata gatcagcttt taaaaggaca acatttagga agaactattt taaaagtata
    10501 agtgtgagta ttcattaata catttactat taattcaatc attttgcatt tctctactaa
    10561 ccagtgttat aatttatata acgaaaatga ttaacaatta atgcaccaat ccccacacta
    10621 ttgcagtagt gtggggattt tttcgatgct ggcttataaa gtcgcctatt aattatttgt
    10681 tgcgtttact aagccaataa gtataatacg caacagcaca gccactgatg actggtgcta
    10741 tgatgtgaac gaaaatgatt agcaaagtaa tgcacctcct ctcttcgtca attgacgcct
    10801 gagagatagg cgactctatt attataccat ctgtgaatat acaagcatat ctacttccga
    10861 taagtcgtct tatgttatat aactttgttt tttatagtat caagacaaga agaaactcgt
    10921 ttcaaaaacc ctcatgattt ttagagaaaa actctcttat ttcatcgtct ttaataaaat
    10981 aatatgccat ctttccatct ttataaaaat caagtacctc atttttatat aaaagcctta
    11041 aatgatgtga agttgaagca acactcattt tcaatatcaa agaaatatca caaacacaca
    11101 actcatcttc tttaatcaaa gataatatga ttttcaattt cttctcatca caaatttttt
    11161 ctaaaatgtt aagtaatttc ttagatttat catcttctaa aaaacttaaa gcattgttaa
    11221 ctttatcctc atgtacacag atcacatcac aagtattttc ataactcata taaaatcaca
    11281 ccctaaatta aaatataaat cctaaaattg tttgaatagt gtcattttca ataataataa
    11341 ataaacctaa agctatataa ataatagcca taatccaacg actaaatttc tcaacaattt
    11401 ctccaattcc tggaatatta gctaattttt gtgcagtaaa caccaagaag aaaattaaaa
    11461 ttaaaaagac aaacagagta agtaataaat tagtaacact taatgtcaca aaatacggaa
    11521 caaataaacc aatattatcg gcgccacaac ttgctatcgt aacaattgca accgtaccaa
    11581 ctaatttaga caatcctttt tcattcaatt cttttttagc tctcttttct ccttcacaat
    11641 catcataaat agccacttta attccaagat aaattggtat taaacccaat aaacctaata
    11701 tccacttttc tggaacataa tttaatacaa aagctaaaaa caaactaact aatattaaaa
    11761 taatagaccc taaatattga ccaacataaa tatctctata ttcttttcta gtctttgctc
    11821 tagcaaaaaa tattaataaa attactaata aatcaactgc tgtagcaata taaagaacag
    11881 cagcagcaac aaccgtttga atcataatac acctcattca aaaatatttt tgaatgtatt
    11941 ataacttata tttttaaata atcataggtg ctttattcca attgctttat tgacgttgag
    12001 ccgagcctcg gaacccttaa caatcccaaa acttgtcgaa tggtcggctt aatagctcac
    12061 gctatgccga cattcgtctg caagtttagt taagggttct tctcaacatc aataaatttt
    12121 ttcggcataa atgcgtgtct atgcgtagac atggagacac ttcagaatta tggagtgatt
    12181 acatgagttt aactattttt ctttattcag ttttaggaag tttattagca aattatatct
    12241 acgaaaaatc ttcaaaataa ataacttttt cggttctatt ttgtacactt tatctacctg
    12301 gtagacctaa ttgttattgc tttacaggtc taaaattcgt cgttataatc tagttaaatc
    12361 ccgtaagggc gcacttatac gtcggataaa tcgacatgtg caaaaacgta atcgaccttc
    12421 gtcgattttt ttatttcaaa attaaagaaa cggcttgaga tattccgagc agttataaaa
    12481 attaatttgc gttgaatatt gctactacat tcttgaaaaa gtgatgtaga tttatagccc
    12541 ataacttttt tgaattacat cgacgatacg gcgtcgaaag aaaaataaat agaccgtatg
    12601 aaagaaaaag ctacctcact ttatctgggg tagcttttat tttttatgcc cttattttga
    12661 attttaagag ggcattttaa agatttaggg tgattcatat agttttatat ctaaaactta
    12721 tatatgcttt taaaacgcaa atataagcca aataaatata tgctattttc aaaaacaaaa
    12781 atttgagcaa aaacaataac tatttttaga cactgcccat ttacatgcaa attaaaaatt
    12841 agcataaaat tctttaaaac ttccccacgt ttttctaaat tcctgtaggg cgtttttatc
    12901 aaaaatcaag acaagaagaa actcgttcac actcgtttca aaaaaacaag aaatctaatc
    12961 tatacaccta ccgttttcca acccctcaaa gcatacaaat taaaaacaaa attattcata
    13021 atcttacttt cttttaacaa aaacataaaa accataaata gacaaattaa ctatcaaagg
    13081 caataaacag tataaaaaaa ccacgaataa atcttcatca acatctaaaa taaaaaagaa
    13141 taaaacaatt aacaaaatac taattaacaa acctaaaagt ggcaaacttt ttatatattt
    13201 ttctaaattt tcattcataa aatagactcc tttcaaaaat atgtttataa atatattaaa
    13261 ataaatattg attttataaa gcgcttactt atacaattaa aatatcttat tatcttggag
    13321 gtatcaaatg aaaattataa aattattttc aataatttcc ttgttcctac tggtatttag
    13381 cgcgaatttt tctaatgctt acgcaaatga agaacaaaaa agttctttac tagaaaatca
    13441 aaaagaaaaa ttgaaaagca aaaacatcga agtatcacaa atgaccaaga aagaaataag
    13501 ttttctagaa caattgcaaa ataaaaatga agatatgcaa aaattcgaaa agcaaatgaa
    13561 aaaagaagga tttaaaaaaa taaagctaga agacaaaaat tctaaattaa aatatctagc
    13621 tacagaagca aatgataaaa atgcatatgg ctacatagct aataacgctt ataaaaatga
    13681 aaaacaaaag aaattgtagt ttctgaaaca atatatgata actacaacaa aaaaatcaca
    13741 aaattcattg ccgaaaaaag aagtatgact gaaaacaaag agggaaaaat acttattaac
    13801 aaaaattacg ttgaatataa ggctgaaaaa gttgataaaa acagaccggt aacatatgca
    13861 ggattcaaat ggaacggcaa agcattcgct tgtagtatgg ctggacttta tgcatgtgct
    13921 cactactgtg gagtatgggc aatcgtaaat ccaatagccg gcggtgtatg tgaagcagtt
    13981 tgcggaactg catttgcagc tggatgctct gtaggttgat tttattccaa ttgttttatt
    14041 gacgttgagc ctcggaaccc ttaacaatcc caaaacttgt cgaatggtcg gcttaatagc
    14101 tcacgctatg ccgacattcg tctgcaagtt tagttaaggg ttcttctcaa catcaataaa
    14161 ttttttcggc ataaatacga tgttccttat ttatcctcat aaaaaacaat agctgaaata
    14221 tataaccaat tactgtgtgt ttgaatttct aatacatgaa tatcattctt taaaaaccta
    14281 ttaacttgtt tatctaattg acgatgagta aaagtagcga aagttttaat cttcatgata
    14341 tctctccttt tataaaaata gcaatcctta ttacaatatt aaacactttt attttggatt
    14401 ttaagaggca ttttgaagac ttagaggcaa atcatatagg ttttgtactt aaaaatctat
    14461 acagtctctt aaaacgcaaa tatgagccaa ataaatatat gctaatttca caaacaaaaa
    14521 tttcagcaaa atcagtgact aattttttag atactgccca tttacatgca aatttaaaaa
    14581 ttagcataaa atactttaaa acttccccat gtttttctaa attcctgcag ggcttttctt
    14641 atcaaaaact tagaaatttt aatttaactc taaaatctcc gtaagagcat aagggaaatt
    14701 tgctatcatt caaaaatgat agatctggca aggccagaca ttccaagggt tttaagttat
    14761 tttaaagtga tatcatacaa agctgtagtg tcacactttt gtgacactac atacagcatt
    14821 tgtcacaaaa ataagacagc acttttttac agaaaaacaa taaaaaaaga catcagttat
    14881 cactaatgtc ttaaataata attttgcttt tcgaaattcc aaattgcggt aattgaatgt
    14941 gctttttttc ttcgtctgtc gttttatctt catcacttgt attaatcaaa ttaccatctt
    15001 cggcatcgtc taagtttaaa attttatgct tttgtttaag caatccacca taacttaaca
    15061 tacgttttcg atacaaacct ttttctaaat cacttacaat ttcttgattt ttttcgtcgt
    15121 catcagttaa aaagtcagat gatttaacgg aatattttga tgtctcttcg agtgttataa
    15181 aatcatttga attattgatt aaagatatta tattgtttca tgtttttacg gcgcatataa
    15241 agggcatgtg tttcttcaag ttcagttaga attgtttgca ttaaataagc ttgcattgac
    15301 ttgattgttt ccttttggcc tttaactccc ctatcatgta tagctttttt aagtcttttt
    15361 aaagaagtta atatttcatc ctcaatgtcc tctaacatgt aatgcatatc ttcatgcctt
    15421 gaattaaatg atttttttgc tttaagaata acagccttta tgatttctaa atctctataa
    15481 tcatatttta ataaataatt agttagttgt tctgggaatt cttgcaatag catttcttta
    15541 tcatcaaaat tatgtgtaaa ttgatttgaa tgatttgaat gattactaat ttcatttttg
    15601 tactttatat cattcaagtc attcatatca ttattctcag tatcattaaa gtcaatgtca
    15661 ttaaagtcag tatcattagt gttcgatttt cgaacttctg gacgttcgat tttcgaactt
    15721 ctggacgttc gattttcgaa cttctggacg ttcgattttc gaacttcctt ctcgccgtaa
    15781 ggttcaacat cgttttcttc tttttctatt ttgtaaatat cacgttctgt gacaataggt
    15841 ttcattaaat atagaatatt tggtttattt aaaccacgtc gtttttgaat gagtagacca
    15901 tcgttttcta accctttttt tatttttgtt aacttttctt ttttacaatt taagatttcc
    15961 attagctttt catttgaata aacaaagtaa atgttaccat cttcatcaac ccagctattt
    16021 ttaatagata aatttaagcg atcacgtaag atagcatagg ctattttcat atcattagtt
    16081 agatttttat aattttcact ggtaaagaat actttaggga tttgataaaa tctttctttg
    16141 taattttctt gcactgtaaa atattgattt tgcatgacaa aaaacctctt tccatatttt
    16201 agtttggtaa gaggtaataa aacgttttta tttagcttta catttattta atgatttagg
    16261 tgcttgcact aagatattat tcattatata atacaagtat cgaaaattat ataaataaac
    16321 agtttctaaa cgttttatta ccaaaccccg actattacca gtagttgggg tttttgttat
    16381 attaagttta ttatagcact ttaaataaac ttataaaagg gaaaatatag ctttatcaag
    16441 ggtttataaa cccttgataa atatcataaa cctttcataa acccttgata aaaaggttga
    16501 tggatgttta tttttattta ttaatcactt tattattaag cattataaga ttataatatt
    16561 ttatcaaggg tttataaaca ttttataaag ggttgatgat atgaaaagtg tgaaaaagtt
    16621 gagtgaagaa ttaggggtta gtaagcaaac gatttttaat aatattaagc gattgaatat
    16681 agagacaata aaacaggaaa acacttcgtt tattaaagaa gataccgata tagaaaaaat
    16741 cattcaaaga gtaaatgaaa ataaaaagaa atatggtttt gaaagtacta ctgaagacaa
    16801 acaaaaaaaa gggtcggata atattaattt tgaatcgaaa agcgatgctc aaatagtaga
    16861 aatccttaaa aatcagattg atactttaaa taatcaaatt gaaaaacaag aaagtcgtca
    16921 tgaaacaaca attgaatttt acagaaaaga gttgcaagaa agatcaaaat tgcttgaaaa
    16981 tcagcaagtt ctggcattag agagtaataa aaagattcaa aaattagaaa atcaattaga
    17041 aaaagaaaaa caccttaatt atccctttga tacatctact aacactagac aaaacgttga
    17101 tgcacaagaa aaaacatata ctactaatcc tgtaaatatt aacagagatc aggaagaaac
    17161 taaagaaaca gagattcaat ataaggatat atctggaagt caaagcgacg aaagtacaca
    17221 aggtgaagaa gcaaaaaaag aagacgttcc agctaatcta aatgacaatg atagtgatat
    17281 agaagaaaag agtgaagaaa cggaacctaa aaagggtttt ggagtcgttt gtttggtagc
    17341 taaaataatt gattaggcac taaaagttat aaaattttag tgtcttttat atagtgagaa
    17401 cttctggtaa tcatcgatta tgtaaactaa agtatttcaa ataattaact gtattaatac
    17461 tctcatcatg attgcgttat aaacgttcat ttgaaggtca tctctatcat aaatatttaa
    17521 attaactaaa aattttaatc atctgtttaa tacttatgaa atgtatttac ggtaggtatt
    17581 aaaattgatg aaatttatat aagtgctttc aatgaaaatg accgtttatt tatcctcctg
    17641 atttaaggag ttagaaattt cgaaaacgat tctttccatt tgttgcattt gttccatgtc
    17701 cagatattta atacattata gaaaaccaaa gaccatcact aattaaacgc agttttaaaa
    17761 tttcatcagg attgccttcg tctttaaaat gggcctcttt taatataagt tctactcttt
    17821 catacctaac tctttcaatg ccatcgtttc atacgccgat tctcctgatt ccatagcaaa
    17881 ctcagcgata aacattggga atactgcatt gagttctatt atatgctctt tcattcgtgg
    17941 ccatatttca cctccagctt taccgtatgc tgttataagt tgctctaatc cttcgtcgtc
    18001 gaatacacga tggtgtccta taaagtccat tgatgggtcg gagtgggttg cttcagtcca
    18061 gtctatgaga cctgtgacgt ttgcttggtt atctaccatt atatgtcctg gatgtaagtc
    18121 cccatgtatc atggtcgcat gtcgaggcca tagttcgtcg ttttctaacc attgtttcca
    18181 tctgttccat aattcatctg atacgccata agtttcttta actttattca ttcttctttg
    18241 aaagtcattt tttatttctt gtatggtttt gatatttata tgctgaacgt taatgttttc
    18301 ttctggtatg ttgtgtaaat ctacgagtgt ttcagctaat gtgttaataa agttttctgg
    18361 taatggtttg tgttcaattt cccatacata attttgtatt tctggatcta ttgtggctgc
    18421 gggtttacct gtaagttttg ggtaagcaat aaggtctttt gcatgtactt tccacttcgg
    18481 tatttcaaat gaaacattct tctgtaagaa gtctaccgtt tgtttttcgg gttttgttcg
    18541 tttataaacg tcaggtcttc ttggtagtct caaaacccat tctactccat gtttatcttt
    18601 tccaaatgca acttgaaaat caagtcccga ttcattcaat gagattgttt gaggttggat
    18661 gtgtaattga tatttttctg cacatttaat aatttcatta tgtcgagtca ttttattgga
    18721 tccttatttc tattatattt ttcttgtgaa cgtatttttt atattgatat aaatgaacct
    18781 aatattcaat ataaattagt gtatagtttt taagttatat catgaagaga ttgtcctgtt
    18841 aattcccatt ttttatctga tacatgttta acaaaccttg tatcatgtga tgtaaacaaa
    18901 atgattccag gatatttatt cataaacatt tctaatgctt ctaatgtttt aatatctaaa
    18961 aaattagttg gttcatccaa aattaacata ttcgctttcg ttgaaaataa tactgctaac
    19021 gataatttcg ttctttcccc accactcaaa acattacaag aacgatcaag tgcttcattt
    19081 aaacccaagt tatttaaaat agctctactg aatgattctg atgaatccgt ttcatccatt
    19141 aaatattgca ataatgaaac gtcacgcatg tcttcataag caagttgacg atagtatgcc
    19201 atttgcactt taggagaaca atcaattccc tctatttggt ggtaaatagc ttcaagtaaa
    19261 gttgtcttac ctacaccatt tgcacctacg agcgctatat ttttgccata tggtatttgg
    19321 aatcgtactt gtgttagcag tttttgactt cctttaacca atgttagatt ttgtgcaatg
    19381 attggataat tattatggat atcataaatt ttattttgtg ggaaattgaa ttcatgataa
    19441 ctttgtggtt tttcaacttc ttccaaatgt tccattcttt tttcaatatg cttagcttgt
    19501 ttttgagcag ccttctcaac cgtgcctttt tgttttgatg cacttaaacg atctggtgct
    19561 atacttttgt ttttttgttt tgatgatgct tgtgccattt gttgcgcttg atttcgttta
    19621 gctttactgg cttgggacaa tctttgtttt tcacttatat actgttcata ttgacgttgt
    19681 tgttctaact gttcttgttc atattgattt tgatactgtg tgtaattacc tttaaacact
    19741 cttattgtgc catcttcttg tatatcccaa attgtgtcag caatttggtc tataagtgct
    19801 ctatcatgac ttactataat taaagtacca tagtaatatt ttaaaatatt tttcagataa
    19861 tctttaccaa ttttatccaa gtgatttgta ggttcatcta aaagtaatat cggactataa
    19921 tttgatatga cattagctaa tttatatttt gctttttcac caccactcat actgtcggtt
    19981 gtatgcatag gtatatggag ttcactcatt aaactaccgt ctaacgtgtt aaaatcattt
    20041 tccacatcca tgttaagctg ttcaaaatat tgaatttcgc caaccgtttc aactgttcca
    20101 gattctggtt ttgttttttg agcaatcata tttagtaatg tggttttgcc agtaccatta
    20161 ccccaataag tgctattttt tcaaattggt aagcgtaaag atgaccgatg ttaagtgatc
    20221 gtaaatctgt caatttatga ttgatttggt taaatttaat tgtatattgt tccatattta
    20281 tacactcctt gtatatttaa aggacgtgta cgcaaaaaaa tgagacaggc tactcccgtc
    20341 tcattcacat tacactttca aacacttaaa aatttattat gatgttttag tatttgaaag
    20401 cgtttattat tcctatcgaa ggataaaaaa tgacataagt catcctatga gtgtgtattg
    20461 cggacaagcc tttttgaatt aatttagttt tgtattcaaa aaggtttatt tgagtctcat
    20521 agaagctgtc attttaatcc tccttcatcg ataaaatagt aatgttaata taacattttg
    20581 ttggtttttt tacaatatat ctctaagtag aaagattata taacaaaagt ataaaaatac
    20641 aattttagat tgattataca tctccttaat ttagagtgta ctcataaaat acggttctgt
    20701 tgcaaagttg aatttataat ataattttaa caaaaaggag tcttctgtat gaactatttc
    20761 agatataaac aatttaacaa ggatgttatc actgtagccg ttggctacta tctaagatat
    20821 gcattgagct atcgtgatat atctgaaata ttaagagaac gtggtgtaaa cgttcatcat
    20881 tcaacgatct accgttgggt tcaagaatat gccccaattt tatatcaaat ttggaagaaa
    20941 aagcataaaa aagcttatta caaatggcgt attgatgaga cgtatatcaa aataaaagga
    21001 aaatggagct atttatatcg tgccattgat acagagggac atacattaga tatttggttg
    21061 cgtaagcaac gagataatca ttcagcatat gcgtttatca aacgtctcat taaacaattt
    21121 ggtaagcctc aaaaggtagt tacagatcag gcaccttcaa cgaaggcagc aatggctaaa
    21181 ataattaaag cttttaaact taaacctgac tgtcattgta catcgaaata tctgaataac
    21241 ctcattgagc aagatcaccg tcatattaaa gtaagaaaga caagatatca aagtatcaat
    21301 acggcaaaga atactttaaa aggtattgaa tgtatttacg ctctatataa aaagaaccgt
    21361 aggtctcttc agatctacgg attttcccca tgccacgaaa ttagcatcat gctagcaagt
    21421 taaacgaaca ctgacatgat atattagtga ttagctatat tttttacttt gcaacagaac
    21481 cagccattta atatgactgt tacaattact aagattcaag cactattacg ccgcacgtat
    21541 gatttcacca ctcaagttaa taatttaaca gtagatgatt gcgagttact acttgatgca
    21601 gcaaagctta aatttaatga agaaaccata gacctgacac acactgaatt gcaaatcatg
    21661 catagcttat tccagaacaa gggcaaattc gtcagtcgta atgcgttaat cgaaaaatgc
    21721 tgggaatcag aacacttcat tgatgacaat acgcttgctg tcaacattac acgtttacgc
    21781 aaaaagctac aaaaactagg acttacagat tttatcgaaa cgaagaaaaa tgtcggatat
    21841 cgtgtaggtg acgtatgaat ttcttgaaat caatccaacg tgaaatttat attgtcatcc
    21901 ttacttgtgc tttattctac tttatattat tcatgtataa tgtgccgatg caagcatata
    21961 tgattggtct aggtattgta ttgtttgttt caatgattta ctggggtatc cattacatga
    22021 actttaaaaa agaataaaca ctacaggaac agaacgaaga tttaagaatc gaaaaccata
    22081 aacttcgtaa tgactttatt aactaccaaa gtgagttaga gtcatatttt ttaatgtggg
    22141 tgcatcaaat caagacaccg attacagcat caaagttact gcttgaagat cctgatgaac
    22201 acgtgatttc taacgtgcgt aatgaagtct tacaaattga taattacacg aatcttgcac
    22261 tgaactattt gaaactcatg aaccaaaaga catacatggt ctttatggaa gtgagtgtag
    22321 atgaattaat tcgaccactg attaaacgtt atgcgataca gtttattcat catcaaacaa
    22381 agttgcatta tgagaaaagt gaagcggtta tattaacaga tgccaaatgg gcatcaatta
    22441 tgattgagca aatattaaac aatgcattaa aatatgcacg tggcaaagat gtgtggatta
    22501 cgtttgacga aaatacaaag aaattatcaa tccgagataa cggtatcggc attaatgcga
    22561 gtgatttacc gaaaatcttt gataaaggtt tctcgggcta taacggtaga ataagtgaga
    22621 aatcaagcgg tattggttta tatattgtca gcacaatctc aaagcgctta ggccataaag
    22681 taagtgctac atctacatta aacgatggtt caatattcac cattcaattt aaataactcc
    22741 aatctttcat ttttgtaaga ttagcggctg tttttgtaag aatagataaa ggcagccttt
    22801 tctaatcgcg cgtaagataa aggtaacaac aaactaagaa aggtgccaga ggtgaaaaat
    22861 ttgaataata taattgaaat aaataactta acaaagcaat atggaagtca gatagcagtt
    22921 aataatttga gtataactgt tgaaagtgga caaatttatg gttttttagg aagaaatggt
    22981 gcaggcaaaa caactactat aagaatgctt ttaggcttaa ttaaacctac gaaaggtaat
    23041 attaaaatat ttgaaaaaga gttcgaaagt aataaaactg aaattttaaa aaatattggt
    23101 gctatggttg aaacgccagg tttttatagt aatttgacag ctaaagagaa cttaactata
    23161 aatgctaaaa tattaggtat acaaaaagaa aatgcaattg aagaagtgtt agaaatagta
    23221 ggactagctt ctgaaaaagt aaaattgttt aaaaattatt ctttaggtat gaagcaacgt
    23281 ttagggattg cgagagcttt attgcacaat cccgaattat tgatacttga tgagccgacg
    23341 aatggattag atcctattgg cataaaagaa attagaaagt tgattaagga tctggctcaa
    23401 tctagaaata taaccatttt aatttcaagt catatattgt cagaaataga gcagttagta
    23461 gacaaggtgg gtattattca taacggagtt ttgttagaag aaattatgta tgaagattta
    23521 aaaaaaaaga acagacaatt tataagtata tcagtatcag atgaagaaaa agttgcatgt
    23581 ttgttggaaa ctaacttcgg aatttatgac tataaaatta aagaaaatgg cgaatttaaa
    23641 atttattcac atattgatag acaacaagaa attaatagat tattagtatt aaacaatatt
    23701 gatgttttcc agatgagagt gatagaagat aatctagaaa cttatttcga agacttagta
    23761 ggaggtggca caattggata atctactccg tacagaattt attaagttaa aaagatcata
    23821 tatgtttcta ataagtattt taggtacatg cgtagcacct tttatggtgg ttgtagcttc
    23881 ttttattagt atgcggacga aagtaccgac tcctaatatt gtatttaaac agttatttga
    23941 agaagtcagt ttatatcata tgctaattat tggacctcct ctatatgggg ttataatagc
    24001 ctatttgttt ggaagagaat atatagaaga tactttaaaa aacttattaa ttatacctat
    24061 atctagagaa agttttttag taagtaaaat aatattatta ttcttgtgga ttcaaacact
    24121 atctgttatt gcatggttgc taactttaat gctaggtatg ctattgcatt ttcaagggtt
    24181 aagccagagt ttaataattg attcattctt tacatttgtt attggcggag tgttattatg
    24241 gatattatct ccaccaataa ttattttgtc gatatatttt aaaaattatg ttcccacaat
    24301 tgttttaacc ataataatta ctttgataaa tttaatgact gctaattctg aacatagagg
    24361 attatttcct tgggctgcag ttggagacat atctagagga acattaccta atacttatcc
    24421 atttctatta tctttaatta tcataattgt tacatctata ttcagtgtaa ttatattatt
    24481 ctcatacttt aaaaaaactg atataagtta aaaggaggag aaaaatgggt tttatagagc
    24541 agattaaagc atttatttta ggtgtagttg aagggttgac agaatttgct ccagtatcat
    24601 caacaggtca tatgattatt gttgatgata tgtggttaaa cactgctgac gatttaggaa
    24661 gtgcgtctgc aactactttt aaggtggtaa tacagttagg aggttctgtt gcaaagttga
    24721 atttataata taattttaac aaaaaggagt cttctgtatg aactatttca gatataaaca
    24781 atttaacaag gatgttatca ctgtagccgt tggctactat ctaagatatg cattgagcta
    24841 tcgtgatata tctgaaatat taagagaacg tggtgtaaac gttcatcatt caacgatcta
    24901 ccgttgggtt caagaatatg ccccaatttt atatcaaatt tggaagaaaa agcataaaaa
    24961 agcttattac aaatggcgta ttgatgagac gtatatcaaa ataaaaggaa aatggagcta
    25021 tttatatcgt gccattgata cagagggaca tacattagat atttggttgc gtaagcaacg
    25081 agataatcat tcagcatatg cgtttatcaa acgtctcatt aaacaatttg gtaagcctca
    25141 aaaggtagtt acagatcagg caccttcaac gaaggcagca atggctaaaa taattaaagc
    25201 ttttaaactt aaacctgact gtcattgtac atcgaaatat ctgaataacc tcattgagca
    25261 agatcaccgt catattaaag taagaaagac aagatatcaa agtatcaata cggcaaagaa
    25321 tactttaaaa ggtattgaat gtatttacgc tctatataaa aagaaccgta ggtctcttca
    25381 gatctacgga ttttccccat gccacgaaat tagcatcatg ctagcaagtt
//
