LOCUS       CP052026               24114 bp    DNA     circular BCT 24-SEP-2020
DEFINITION  Staphylococcus aureus strain ER05322.3 plasmid pER05322.3A.1,
            complete sequence.
ACCESSION   CP052026
VERSION     CP052026.1
DBLINK      BioProject: PRJNA470993
            BioSample: SAMN14669381
KEYWORDS    .
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 24114)
  AUTHORS   Caban,A.B., Pak,T., Kumaresh,A., Dupper,A., Chacko,K.,
            Sullivan,M.J., Altman,D.R. and van Bakel,H.
  TITLE     PathoSPOT genomic surveillance reveals prolonged under the radar
            outbreaks of nosocomial methicillin resistant S. aureus bloodstream
            infections
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 24114)
  AUTHORS   Caban,A.B., Pak,T., Kumaresh,A., Dupper,A., Chacko,K.,
            Sullivan,M.J., Altman,D.R. and van Bakel,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2020) Genetics and Genomic Sciences, Icahn School
            of Medicine, One Gustave L. Levy Place Box 1498, New York, NY 10029,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 153.556891135303x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/23/2020 11:25:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 2,912
            CDSs (total)                      :: 2,830
            Genes (coding)                    :: 2,750
            CDSs (with protein)               :: 2,750
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 80
            CDSs (without protein)            :: 80
            Pseudo Genes (ambiguous residues) :: 0 of 80
            Pseudo Genes (frameshifted)       :: 48 of 80
            Pseudo Genes (incomplete)         :: 21 of 80
            Pseudo Genes (internal stop)      :: 23 of 80
            Pseudo Genes (multiple problems)  :: 12 of 80
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..24114
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="ER05322.3"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pER05322.3A.1"
                     /geo_loc_name="USA:New York City"
                     /lat_lon="40.7903114 N 73.9528738 W"
                     /collection_date="2016"
                     /collected_by="Mount Sinai Hospital"
     gene            24..218
                     /locus_tag="HIK41_14415"
     CDS             24..218
                     /locus_tag="HIK41_14415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001004925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOC15479.1"
                     /translation="MNENLEKYIKSLPLLGLLISILLIVLFFFILDVDEDLFVVFLYCL
                     LPLIVNLSIYGFYVFVKRK"
                     /name="hypothetical protein"
     gene            1334..1951
                     /gene="cadD"
                     /locus_tag="HIK41_14420"
     ARG             1335..1948
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            1970..2317
                     /locus_tag="HIK41_14425"
     CDS             1970..2317
                     /locus_tag="HIK41_14425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="QOC15481.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNHEGF"
                     /name="helix-turn-helix transcriptional regulator"
     gene            2474..2566
                     /locus_tag="HIK41_14430"
     CDS             2474..2566
                     /locus_tag="HIK41_14430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="QOC15482.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(2738..3709)
                     /locus_tag="HIK41_14435"
     CDS             complement(2738..3709)
                     /locus_tag="HIK41_14435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="QOC15483.1"
                     /translation="MFNAVVVRKSASNVSYKVEKVDESHLSKGDVLVKVVYSSINYKDM
                     LALQYKGGVIRDYPMIPGIDFAGIVESSSNDKFKEGDNVLVTGYDVGVTHTGGFSEYAQ
                     VPGEWIVPIPQEMSIKESMVYGTAGFTAALSIFELEKYGMNIKSQPEILVSGATGGVGS
                     VAIQILHKIGYENITAIVRKEKQIEIAKKLGAKQVIIIEDDNKPLKKGIFDYFLDTVGS
                     NVTLYGLKRLNYQGVATVCGNVAGNSLNANILPFILRGIKLIGIDSVYVDHNIREDIWS
                     KLANEWNIGNSLLYNEIGFEEFYKTIDQLLKGQHLGRTILKV"
                     /name="oxidoreductase"
     gene            3833..4252
                     /locus_tag="HIK41_14440"
                     /pseudo=""
     CDS             3833..4252
                     /locus_tag="HIK41_14440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418035.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /name="MarR family transcriptional regulator"
     gene            complement(4778..5623)
                     /gene="blaZ"
                     /locus_tag="HIK41_14445"
     ARG             complement(4782..5623)
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            5730..7487
                     /gene="blaR1"
                     /locus_tag="HIK41_14450"
     ARG             5731..7484
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="95.38"
                     /coverage="100.0"
     gene            7477..7857
                     /gene="blaI"
                     /locus_tag="HIK41_14455"
     ARG             7478..7854
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="98.41"
                     /coverage="100.0"
     gene            8121..8699
                     /locus_tag="HIK41_14460"
     CDS             8121..8699
                     /locus_tag="HIK41_14460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="QOC15487.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNKQDLNLLKTLYDNGTPI
                     KTIAEQWQVSRTTIYRYLNKLEAKENKNK"
                     /name="recombinase family protein"
     gene            complement(8922..9107)
                     /locus_tag="HIK41_14465"
     CDS             complement(8922..9107)
                     /locus_tag="HIK41_14465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001037130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOC15488.1"
                     /translation="MNKLEKWSLVFIIFTFLSSLALLYFKYNFSSVMPVLSLSILTILI
                     LLTSIITVVSVNDEDT"
                     /name="hypothetical protein"
     gene            9369..10043
                     /locus_tag="HIK41_14470"
     CDS             9369..10043
                     /locus_tag="HIK41_14470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="QOC15489.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            complement(10105..10176)
                     /locus_tag="HIK41_14475"
                     /pseudo=""
     CDS             complement(10105..10176)
                     /locus_tag="HIK41_14475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032491779.1"
                     /note="internal stop; incomplete; partial on complete
                     genome; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside 6-adenylyltransferase"
                     /name="aminoglycoside 6-adenylyltransferase"
     gene            complement(10305..10979)
                     /locus_tag="HIK41_14480"
     CDS             complement(10305..10979)
                     /locus_tag="HIK41_14480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="QOC15490.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            complement(11009..11212)
                     /locus_tag="HIK41_14485"
     CDS             complement(11009..11212)
                     /locus_tag="HIK41_14485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001627151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP kinase"
                     /protein_id="QOC15491.1"
                     /translation="MGFIEQIKAFILGVVEGLTEFAPVSSTGHMIIVDDMWLNTADDLG
                     SASATTFKVVIQLGGSVAKLNL"
                     /name="UDP kinase"
     gene            complement(11226..11963)
                     /locus_tag="HIK41_14490"
     CDS             complement(11226..11963)
                     /locus_tag="HIK41_14490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000369394.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="QOC15492.1"
                     /translation="MDNLLRTEFIKLKRSYMFLISILGTCVAPFMVVVASFISMRTKVP
                     TPNIVFKQLFEEVSLYHMLIIGPPLYGVIIAYLFGREYIEDTLKNLLIIPISRESFLVS
                     KIILLFLWIQTLSVIAWLLTLMLGMLLHFQGLSQSLIIDSFFTFVIGGVLLWILSPPII
                     ILSIYFKNYVPTIVLTIIITLINLMTANSEHRGLFPWAAVGDISRGTLPNTYPFLLSLI
                     IIIVTSIFSVIILFSYFKKTDIS"
                     /name="ABC transporter permease"
     gene            complement(11956..12885)
                     /locus_tag="HIK41_14495"
     CDS             complement(11956..12885)
                     /locus_tag="HIK41_14495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000074567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="QOC15493.1"
                     /translation="MKNLNNIIEINNLTKQYGSQIAVNNLSITVESGQIYGFLGRNGAG
                     KTTTIRMLLGLIKPTKGNIKIFEKEFESNKTEILKNIGAMVETPGFYSNLTAKENLTIN
                     AKILGIQKENAIEEVLEIVGLASEKVKLFKNYSLGMKQRLGIARALLHNPELLILDEPT
                     NGLDPIGIKEIRKLIKDLAQSRNITILISSHILSEIEQLVDKVGIIHNGVLLEEIMYED
                     LKKKNRQFISISVSDEEKVACLLETNFGIYDYKIKENGEFKIYSHIDRQQEINRLLVLN
                     NIDVFQMRVIEDNLETYFEDLVGGGTIG"
                     /name="ABC transporter ATP-binding protein"
     gene            complement(13001..13882)
                     /locus_tag="HIK41_14500"
                     /pseudo=""
     CDS             complement(13001..13882)
                     /locus_tag="HIK41_14500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_501406.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /name="HAMP domain-containing histidine kinase"
     gene            complement(13879..14256)
                     /locus_tag="HIK41_14505"
                     /pseudo=""
     CDS             complement(13879..14256)
                     /locus_tag="HIK41_14505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000866106.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /name="response regulator transcription factor"
     gene            complement(14314..14988)
                     /locus_tag="HIK41_14510"
     CDS             complement(14314..14988)
                     /locus_tag="HIK41_14510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="QOC15494.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            15462..16927
                     /gene="msr(A)"
                     /locus_tag="HIK41_14515"
                     /pseudo=""
     ARG             15576..16924
                     /name="msr(A)"
                     /gene="msr(A)"
                     /gene_name="ABC-F type ribosomal protection protein Msr(A)"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE/STREPTOGRAMIN"
                     /identity="100.0"
                     /coverage="92.21"
     gene            17026..17925
                     /gene="mph(C)"
                     /locus_tag="HIK41_14520"
     ARG             17027..17922
                     /name="mph(C)"
                     /gene="mph(C)"
                     /gene_name="Mph(C) family macrolide 2'-phosphotransferase"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            18411..19019
                     /locus_tag="HIK41_14525"
     CDS             18411..19019
                     /locus_tag="HIK41_14525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002474535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="QOC15496.1"
                     /translation="MIIGYARVSSIDQNLERQLDNLKTFGVEKIFTEKQSGKSVENRPV
                     FQEALNFVRMGDRFVVESIDRLGRNYDEIIETVNYLKEKDVQLMITSLPMMNEVIGNPL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRV
                     IYHRVVEMLEEGKAISKIAKEVNITRQTVYRIKHDKGLS"
                     /name="recombinase family protein"
     gene            19265..19603
                     /locus_tag="HIK41_14530"
     CDS             19265..19603
                     /locus_tag="HIK41_14530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001049146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOC15497.1"
                     /translation="MNLIPFIIILIFSCLWTAITNKYLPSETLDKKGQQDRYDERQRKM
                     FIEILAKSFIWIVYCMLFTLVLKFTGLSPSIEGSWFSQYPEIFFIIVALFLMLFNYYTT
                     NKKYTSKG"
                     /name="hypothetical protein"
     gene            19608..19793
                     /locus_tag="HIK41_14535"
     CDS             19608..19793
                     /locus_tag="HIK41_14535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016912974.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="QOC15498.1"
                     /translation="MKNRIREYRKQKGISQETLSKELKVSRQTINAIENNKYDPTLTLA
                     FKLARLFDTTVDELFS"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(20020..20763)
                     /locus_tag="HIK41_14540"
     CDS             complement(20020..20763)
                     /locus_tag="HIK41_14540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002508633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="QOC15499.1"
                     /translation="MKSVKKLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESTTEDKQKKGSDNINFESKSDAQIVEILKNQIDTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNTR
                     QNVDAQEKTYTTNPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAKKEDVPANLND
                     NDSDIEEKSEETEPKKGFWSRLFGS"
                     /name="DUF536 domain-containing protein"
     gene            21189..22170
                     /locus_tag="HIK41_14545"
                     /pseudo=""
     CDS             21189..22170
                     /locus_tag="HIK41_14545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /name="replication initiator protein A"
     gene            22163..22479
                     /locus_tag="HIK41_14550"
                     /pseudo=""
     CDS             22163..22479
                     /locus_tag="HIK41_14550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002483623.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            23024..23173
                     /locus_tag="HIK41_14555"
     CDS             23024..23173
                     /locus_tag="HIK41_14555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000695367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOC15500.1"
                     /translation="MKIKTFATFTHRQLDKQVNRFLKNDIHVLEIQTHSNWLYISAIVF
                     YEDK"
                     /name="hypothetical protein"
     gene            complement(23340..24029)
                     /locus_tag="HIK41_14560"
                     /pseudo=""
     CDS             complement(23340..24029)
                     /locus_tag="HIK41_14560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691527.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     ARG             15609..16927
                     /name="msrA"
                     /gene="msrA"
                     /gene_name="msr-type ABC-F protein"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; streptogramin
                     antibiotic; streptogramin B antibiotic"
                     /identity="98.41"
                     /coverage="89.96"
     ARG             15463..15605
                     /name="msrA"
                     /gene="msrA"
                     /gene_name="msr-type ABC-F protein"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; streptogramin
                     antibiotic; streptogramin B antibiotic"
                     /identity="97.37"
                     /coverage="9.63"
     ARG             17027..17925
                     /name="mphC"
                     /gene="mphC"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="98.66"
                     /coverage="100.0"
     ARG             complement(4779..5623)
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.8"
                     /coverage="100.0"
     Typing          22535..22681
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="99.329"
                     /coverage="100.0"
                     /evalue="1e-69"
     Typing          complement(20021..20763)
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          21190..22170
                     /name="rep_cluster_2100"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.39"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          22302..22471
                     /name="rep_cluster_1017"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="93.605"
                     /coverage="91.0"
                     /evalue="1.04e-65"
ORIGIN
        1 tatttttgaa aggagtctat tttatgaatg aaaatttaga aaaatatata aaaagtttgc
       61 cacttttagg tttgttaatt agtattttgt taattgtttt attctttttt attttagatg
      121 ttgatgaaga tttattcgtg gtttttttat actgtttatt gcctttgata gttaatttgt
      181 ctatttatgg tttttatgtt tttgttaaaa gaaagtaaga ttatgaataa ttttgttttt
      241 aatttgtatg ctttgagggg gttggaaaac ggtaggtgta tagattagat ttcttgtttt
      301 tttgaaacga gtgtgaacga gtttcttctt gtcttgattt ttgataaaaa cgccctacag
      361 gaatttagaa aaacgtgggg aagttttaaa gaattttatg ctaattttta atttgcatgt
      421 aaatgggcag tgtctaaaaa tagttattgt ttttgctcaa atttttgttt ttgaaaatag
      481 catatattta tttggctcat atttgcgttt taaaagcata tataagtttt agatataaaa
      541 ctatatgaat cacccctaaa tctttaaaat gccctcttaa aattcaaaat aagggcataa
      601 aaaataaaag ctaccccaga taaagtgagg tagctttttc tttcatacgg tctatttatt
      661 tttctttcga cgccgtatcg tcgatgtaat tcaaaaaagt tatgggctat aaatctacat
      721 cactttttca agaatgtagt agcaatattc aacgcaaatt aatttttata actgctcgga
      781 atatctcaag ccgtttcttt aattttgaaa taaaaaaatc gacgaaggtc gattacgttt
      841 ttgcacatgt cgatttatcc gacgtataag tgcgccctta cgggatttaa ctagattata
      901 acgacgaatt ttagacctgt aaagcaataa caattaggtc taccaggtag ataaagtgta
      961 caaagtagaa ccgaaaaagt tatttatttt gaagattttt cgtagatata atttgctaat
     1021 aaacttccta aaactgaata aagaaaaata gttaaactca tgtaatcact ccataattct
     1081 gaagtgtctc catgtctacg catagacacg catttatgcc gaaaaaattt attgatgttg
     1141 agaagaaccc ttaactaaac ttgcagacga atgtcggcat agcgtgagct attaagccga
     1201 ccattcgaca agttttggga ttgttaaggg ttccgaggct caacgtcaat aaagcaattg
     1261 gaataaagca cctatgatta tttaaaaata taagttataa tacattcaaa aatatttttg
     1321 aatgaggtgt attatgattc aaacggttgt tgctgctgct gttctttata ttgctacagc
     1381 agttgattta ttagtaattt tattaatatt ttttgctaga gcaaagacta gaaaagaata
     1441 tagagatatt tatgttggtc aatatttagg gtctattatt ttaatattag ttagtttgtt
     1501 tttagctttt gtattaaatt atgttccaga aaagtggata ttaggtttat tgggtttaat
     1561 accaatttat cttggaatta aagtggctat ttatgatgat tgtgaaggag aaaagagagc
     1621 taaaaaagaa ttgaatgaaa aaggattgtc taaattagtt ggtacggttg caattgttac
     1681 gatagcaagt tgtggcgccg ataatattgg tttatttgtt ccgtattttg tgacattaag
     1741 tgttactaat ttattactta ctctgtttgt ctttttaatt ttaattttct tcttggtgtt
     1801 tactgcacaa aaattagcta atattccagg aattggagaa attgttgaga aatttagtcg
     1861 ttggattatg gctattattt atatagcttt aggtttattt attattattg aaaatgacac
     1921 tattcaaaca attttaggat ttatatttta atttagggtg tgattttata tgagttatga
     1981 aaatacttgt gatgtgatct gtgtacatga ggataaagtt aacaatgctt taagtttttt
     2041 agaagatgat aaatctaaga aattacttaa cattttagaa aaaatttgtg atgagaagaa
     2101 attgaaaatc atattatctt tgattaaaga agatgagttg tgtgtttgtg atatttcttt
     2161 gatattgaaa atgagtgttg cttcaacttc acatcattta aggcttttat ataaaaatga
     2221 ggtacttgat ttttataaag atggaaagat ggcatattat tttattaaag acgatgaaat
     2281 aagagagttt ttctctaaaa atcatgaggg tttttgaaac gagtttcttc ttgtcttgat
     2341 actataaaaa acaaagttat ataacataag acgacttatc ggaagtagat atgcttgtat
     2401 attcacagat ggtataataa tagagtcgcc tatctctcag gcgtcaattg acgaagagag
     2461 gaggtgcatt actttgctaa tcattttcgt tcacatcata gcaccagtca tcagtggctg
     2521 tgctgttgcg tattatactt attggcttag taaacgcaac aaataattaa taggcgactt
     2581 tataagccag catcgaaaaa atccccacac tactgcaata gtgtggggat tggtgcatta
     2641 attgttaatc attttcgtta tataaattat aacactggtt agtagagaaa tgcaaaatga
     2701 ttgaattaat agtaaatgta ttaatgaata ctcacactta tacttttaaa atagttcttc
     2761 ctaaatgttg tccttttaaa agctgatcta tcgttttata gaattcttca aatccaattt
     2821 cattgtatag aagtgaattt cctatattcc attcatttgc taacttactc catatatctt
     2881 cacggatatt atgatcaaca tatacagaat caatgccaat taatttaata cctctaagaa
     2941 taaacggtaa tatattagcg ttaagtgaat ttcctgctac atttccacat acagtagcaa
     3001 caccttgata atttagacgt tttaaaccgt ataatgttac attactcccc actgtatcta
     3061 agaaataatc aaaaatacct tttttaagcg gtttattatc atcttcaatt attattactt
     3121 gttttgcacc taattttttt gcgatttcta tttgcttttc ttttcttacg atagcagtga
     3181 tattttcata tccaatttta tgtaaaattt gtatagcaac actgcccaca ccacctgtag
     3241 ccccagacac taaaatttca ggttgtgatt tgatattcat tccatatttt tctagttcaa
     3301 aaattgataa tgctgccgta aaaccggctg tgccatatac catagactct ttaatagaca
     3361 tttcttgggg aataggaaca atccactctc caggcacttg tgcatattct gaaaatccac
     3421 ctgtatgtgt cacgccaaca tcataaccag taactaatac attatcgcct tctttaaact
     3481 tatcattcga acttgattca acaatacctg caaaatctat accaggaatc ataggataat
     3541 ctctaattac accgccttta tattgtaaag ctagcatatc cttataattt attgaagagt
     3601 ataccacttt tactaataca tcacccttcg ataaatgaga ttcatcaact ttttctactt
     3661 tataactaac atttgatgca ctttttctca ctactaccgc attgaacatt tattagcctt
     3721 ctttcacaat tgttttgtag aagtatgttt ttgttgcaaa actattttcc tacaaaactt
     3781 atcatgatat gataagcgag tcaatactaa tgatttaaga gaggttttag ttgtgtaatt
     3841 agataattgt ataaattatt tgttgagtac ttctcagaat agagttttta aacattttaa
     3901 aagtttatta agtccctata atattactcc agcagaatat ggtgttttga attgcttgat
     3961 taatagtaat ttgaatacac ctaaagcgat tggtaatact ttaaatttag aaccttcaac
     4021 aatatctgga atattagata agatgtccaa aaaggatcta ataacacgtc aaactgataa
     4081 tgaaaataga agaactgtgc taataaacag tacaaataaa gcaaaagact tatggccaac
     4141 attagaaaag aaagcctatc aacttaataa tcattacttc gctaatttaa ctaatgaaga
     4201 aactgtagtg tttaaaaaga tattactaaa gataaataaa actacgtttt aatttttacg
     4261 ttataaaaaa gttgaagtgc gaattataat cgagtaaata taaatgatag cttagcttaa
     4321 ttatatatta aagccaacta tacttttatt cccgaaaaac ctactatcca aatttctaag
     4381 atactttagc ctctataata aacatattgt aatataattt atgtattatt taggtttacc
     4441 ctaatcgaac aataaaaaat acttgtaaaa tgctattgtc actttgcttg atatatgaga
     4501 attatttaac cttataaatg agaaaaaagc aacgcacttt aaataagata cgttgctttt
     4561 tcgattgatg aacacctata attaaactat tcatctatta tttatgattt tttgtatata
     4621 caatatttct agtttgttaa agagaattaa gaaaataaat ctcgaaaata ataaagggaa
     4681 aatcagtttt tgatatcaaa attatacatg tcaacgataa tacaaaatat aatacaaact
     4741 ataagatgtt atcagtattt attatgcatt tagaatatta aaattccttc attacactct
     4801 tggcggtttc acttatcaac ttatcatttg gcttatcact tttattgtct ttattcgtaa
     4861 aaatgactaa aacaataggt tcagattggc ccttaggata aacaaaagca acatcatttc
     4921 tagaagcata tgttattgct tgaccacttt tatcagcaac cttatagtct tttggaacac
     4981 catctttaat taaagtgtct ccgtttttat tattaaacat taaatcaagt aagaaatttt
     5041 tatttttttt gcttaatttt ccatttgcga taagtttatt taaagtcttg ccgaaagcag
     5101 caggcgttga agtatctttt ttgctctttg gtgaatagta atttaattct atctcatatc
     5161 taactggatt tgttacttta tctcctagtt cttttagacg ttgtttaact tttttgattc
     5221 caccgatttc ttttataatt ttattgtttg ctgtattatc actatatgtc attgaagcct
     5281 caataagttc ttttaaagtg atatcttttc ctacatattt ttctaaaata ggagaataag
     5341 caactatatc atctttgtta atatgtactt ttttatttaa cttattataa ggtacttgtt
     5401 ctaacaaaat agcactattt atcgcttttg aagtcgaagc ataggcaaat ctcttatctg
     5461 aattaaattt tacttcctta ccacttttag tatttaaagc ataaacacca atatgagcat
     5521 tatatttttt ttctaaatca tttaactctt tggcatgtga actgtttgaa ttacatgcac
     5581 ttaaaactaa agcaattaca attaaaaata ttaacttttt caaaataaac cctccgatat
     5641 tacagttgta atttttataa atcaataata ttacaattgt aatattgatg tcaattgttt
     5701 attataaata tttgaaagaa ggtttcaaaa tggctaaatt actaataatg agcgtagtaa
     5761 gcttttgttt tatatttcta ttgttagtat tttttaggta catattaaaa cgctatttta
     5821 attatagttt aaattataaa gtttggtatc taactatgct tgctggatta attcctttta
     5881 tcccaattaa attctctttt ataaaattta ataatgtgaa taatcaagcg cccacagttg
     5941 aaagtaagtc acacgatttg aaccataaca taaataccac caaacctatt caagagttca
     6001 caacagatat ccataagttt aattgggatt caattgataa tatctgcaca gttatttgga
     6061 tagttttagt tattatttta agttttaaat ttttgaaagc cttattatat cttaaatatt
     6121 taaagaaaca gtcactttat ctaaacgaaa atgaaaaaaa taaaatagat acgatacttt
     6181 tcaaccatca atataaaaaa aatattgtga ttcgaaaagc agaggctatt caatctccaa
     6241 taactttttg gtatgggaaa tatattattt tgattcctag ttcatatttt aaaagtgtaa
     6301 ttgataaaag actaaaatat ataatactgc atgaatatgc tcatgctaaa aatagagata
     6361 ctttacattt aattatcttt aatatcttct ctattattat gagttacaat ccattagtac
     6421 atattgtaaa aagaaagata attcatgaca atgaagtaga agccgataga tttgtcctta
     6481 ataatattaa caaaaatgaa tttaaaactt atgcggaatc tattatggac tccgtattaa
     6541 aaaccccatt ttccaacaaa aatatattaa gccattcatt taatggtaaa aaatcattac
     6601 tcaaaagtag attaattaat ataaaagaag ccgatctgaa aaagcagtca aaattaattc
     6661 taatttttat ttgtattttt acttttttta tcatgataat tcaaagccag tttttaatgg
     6721 ggcaatcctt aactgattat aattataaaa agcccttaca aagcgattac caaattttag
     6781 atgaaagtaa aaattttggt tcaaatagtg gatctttcgt tatgtacagc atgaagaaag
     6841 acaaatacta tatttataat gaaaaagaaa gtagaaaaag atattctcct gattcaactt
     6901 acaaaattta tttagcactg tttggacttg accgtcatat tataagtgat aaaaattcac
     6961 gtatgtcatg gaatcataaa cattatcttt tcgagtcttg gaataaggaa caagatttaa
     7021 atacagcaat gcaaaattca gttaattggt acttcgaacg tattagtaat caaataccaa
     7081 agaactatac tgcggctcaa ctcaagcaat taaattatgg taatgaaaat ttgggaagtt
     7141 ataaaagcta ttggatggaa gatagtttga aaatatctaa tcttgaacaa gtaatagttt
     7201 ttaaaaatat gatggaacaa aataaccatt ttagtaaaaa agcaaagaat caattatctt
     7261 cttcattatt gattaagaaa aatgaaaagt atgaactgta tgggaaaaca ggtacaggta
     7321 tagtaaacgg gaagtataat aatgggtggt ttgtaggtta cgtaattaca aatcatgata
     7381 agtattattt tgctacacat ttatcagatg gaaacccgtc tgggaaaaat gctgaattaa
     7441 taagtgaaaa aatattaaaa ggaatgggtg ttttaaatga ccaataagca agttgaaata
     7501 tctatggctg aatgggatgt tatgaatata atatgggata aaaaatcagt atcagctaat
     7561 gaaattgtag ttgaaattca aaaatataaa gaagttagtg ataaaacgat tagaacatta
     7621 atcacaagac tatataaaaa agagattata aaacgataca aatcagaaaa tatttatttt
     7681 tactcatcaa atattaaaga agacgatatt aaaatgaaaa ctgctaaaac ctttcttaat
     7741 aaactgtatg gaggggatat gaaaagttta gtgctgaatt ttgcgaaaaa tgaagaatta
     7801 aataacaaag aaattgaaga attgcgagac attttaaatg atattagtaa aaagtaatta
     7861 gaggtatgtt tcaaacataa tacatatgta aaccatactt gactcttatt aaattagttt
     7921 tgttaatgac atttaaaata tattattaaa gatgagagtg tccagaaaat aaccattttc
     7981 tgtacactct tgttttttgt ctaaataagt aagtattaca tagaattatg tgttcaaaaa
     8041 cccaacaaaa aatctatgtt cacaaaagac ctcgtaatca agttatggta cactaaaggt
     8101 gtatatagga ggtctgtatt ttgaaaatag gttatgcaag agtttcaact ggattacaaa
     8161 atttgaattt acaggaggat cgattaaata catatggttg tgaaaagata tttaatgacc
     8221 atatgagtgg ttcaaaaagt aagcgacctg gtttagataa agcaattgaa tttgcgaggt
     8281 caggagatac gattgttgtt tggagattag atagactagg acggaacatg gaggatttaa
     8341 tcacgttagt taatgaactt aacgaacgag gtgtgagttt tcatagttta gaagaaaata
     8401 taacgatgga taaatcaagt tctacaggac aattattatt tcatttattc gcagcatttg
     8461 cagagtttga acgtaattta attttagagc gatcatcagc cggtcgaatt gcagcacgtg
     8521 ctagaggccg atatggaggt agacctgaaa aattaaataa acaagattta aacttactta
     8581 agacacttta tgataatggt acgccaatta aaacaattgc agagcagtgg caagtttcac
     8641 gtacaactat ttatcgttat ctcaataaat tagaggcaaa agagaataaa aacaagtaga
     8701 gcaactaatc tagcttacta taatgaatct actaaataat tttatatatc attaacatac
     8761 aaagactttg attcaatgtc actcgatgta aaagagacgt tctgacagcg tctaaaatct
     8821 cataatattt tcctgttatg agattttaat aataacacaa gaaaaaagcg tacaaattcg
     8881 tacgcttttt taatataata cctgtttcac taatgaacgt tttaagtatc ttcatcatta
     8941 actgaaacta cagtaataat actcgtcaac aatattagta tagttaaaat agaaagactt
     9001 aggactggca taaccgaact aaaattatat ttgaaatata aaagtgctaa tgaagagaga
     9061 aatgtaaaaa taataaatac caaagaccat ttttctaatt tattcattgg cttcacctct
     9121 ttgaactttt atataatcat aggagatatt tttactacga tttataaaaa ataagaagat
     9181 aatcattatt aaagaaacga ttaatataat gttgaatcct atagtatcac ctaattcgtt
     9241 tacacctttg cctaatatcg gagatacaaa gctttgtatt aataatgaaa gagatgccca
     9301 tatagtaaat gaggttctgt tgcaaagttg aatttataat ataattttaa caaaaaggag
     9361 tcttctgtat gaactatttc agatataaac aatttaacaa ggatgttatc actgtagccg
     9421 ttggctacta tctaagatat gcattgagct atcgtgatat atctgaaata ttaagagaac
     9481 gtggtgtaaa cgttcatcat tcaacggtct accgttgggt tcaagaatat gccccaattt
     9541 tatatcaaat ttggaagaaa aagcataaaa aagcttatta caaatggcgt attgatgaga
     9601 cgtacatcaa aataaaagga aaatggagct atttatatcg tgccattgat gcagagggac
     9661 atacattaga tatttggttg cgtaagcaac gagataatca ttcagcatat gcgtttatca
     9721 aacgtctcat taaacaattt ggtaaacctc aaaaggtaat tacagatcag gcaccttcaa
     9781 cgaaggtagc aatggttaaa gtaattaaag cttttaaact taaacctgac tgccattgta
     9841 catcgaaata tctgaataac ctcattgagc aagatcaccg tcatattaaa gtaagaaaga
     9901 caaggtatca aagtatcaat acagcaaaga atactttaaa aggtattgag tgtatttacg
     9961 ctctatataa aaagaaccgc aggtctcttc agatctacgg attttcgcca tgccacgaaa
    10021 ttagcatcat gctagcaagt taagcgaaca ctgacatgat aaattagtgg ttagctatat
    10081 ttttttactt tgcaacagaa cctaattatc taactcttcc aagggcaata aggtaagatc
    10141 aattttattg taatcatcaa atagctataa tagatttaga ggtaaagaaa ttaaatacat
    10201 tgaagagcag aaagatttta caaaagagta ttttaataaa aatgatggtt ctgttgcaaa
    10261 gtaaaaaata tagctaacca ctaatttatc atgtcagtgt tcgcttaact tgctagcatg
    10321 atgctaattt cgtggcatgg cgaaaatccg tagatctgaa gagacctgcg gttcttttta
    10381 tatagagcgt aaatacactc aatacctttt aaagtattct ttgctgtatt gatactttga
    10441 taccttgtct ttcttacttt aatatgacgg tgatcttgct caatgaggtt attcagatat
    10501 ttcgatgtac aatggcagtc aggtttaagt ttaaaagctt taattacttt aaccattgct
    10561 accttcgttg aaggtgcctg atctgtaatt accttttgag gtttaccaaa ttgtttaatg
    10621 agacgtttga taaacgcata tgctgaatga ttatctcgtt gcttacgcaa ccaaatatct
    10681 aatgtatgtc cctctgtatc aatggcacga tataaatagc tccattttcc ttttattttg
    10741 atgtacgtct catcaatacg ccatttgtaa taagcttttt tatgcttttt cttccaaatt
    10801 tgatataaaa ttggggcata ttcttgaacc caacggtaga ccgttgaatg atgaacgttt
    10861 acaccacgtt ctcttaatat ttcagatata tcacgatagc tcaatgcata tcttagatag
    10921 tagccaacgg ctacagtgat aacatccttg ttaaattgtt tatatctgaa atagttcata
    10981 cagaagactc ctttttgtta aaattatatt ataaattcaa ctttgcaaca gaacctccta
    11041 actgtattac caccttaaaa gtagttgcag acgcacttcc taaatcgtca gcagtgttta
    11101 accacatatc atcaacaata atcatatgac ctgttgatga tactggagca aattctgtca
    11161 acccttcaac tacacctaaa ataaatgctt taatctgctc tataaaaccc atttttctcc
    11221 tccttttaac ttatatcagt ttttttaaag tatgagaata atataattac actgaatata
    11281 gatgtaacaa ttatgataat taaagataat agaaatggat aagtattagg taatgttcct
    11341 ctagatatgt ctccaactgc agcccaagga aataatcctc tatgttcaga attagcagtc
    11401 attaaattta tcaaagtaat tattatggtt aaaacaattg tgggaacata atttttaaaa
    11461 tatatcgaca aaataattat tggtggagat aatatccata ataacactcc gccaataaca
    11521 aatgtaaaga atgaatcaat tattaaactc tggcttaacc cttgaaaatg caatagcata
    11581 cctagcatta aagttagcaa ccatgcaata acagatagtg tttgaatcca caagaataat
    11641 aatattattt tacttactaa aaaactttct ctagatatag gtataattaa taagtttttt
    11701 aaagtatctt ctatatattc tcttccaaac aaataggcta ttataacccc atatagagga
    11761 ggtccaataa ttagcatatg atataaactg acttcttcaa ataactgttt aaatacaata
    11821 ttaggagtcg gtactttcgt ccgcatacta ataaaagaag ctacaaccac cataaaaggt
    11881 gctacgcatg tacctaaaat acttattaga aacatatatg atctttttaa cttaataaat
    11941 tctgtacgga gtagattatc caattgtgcc acctcctact aagtcttcga aataagtttc
    12001 tagattatct tctatcactc tcatctggaa aacatcaata ttgtttaata ctaataatct
    12061 attaatttct tgttgtctat caatatgtga ataaatttta aattcgccat tttctttaat
    12121 tttatagtca taaattccga agttagtttc caacaaacat gcaacttttt cttcatctga
    12181 tactgatata cttataaatt gtctgttctt tttttttaaa tcttcataca taatttcttc
    12241 taacaaaact ccgttatgaa taatacccac cttgtctact aactgctcta tttctgacaa
    12301 tatatgactt gaaattaaaa tggttatatt tctagattga gccagatcct taatcaactt
    12361 tctaatttct tttatgccaa taggatctaa tccattcgtc ggctcatcaa gtatcaataa
    12421 ttcgggattg tgcaataaag ctctcgcaat ccctaaacgt tgcttcatac ctaaagaata
    12481 atttttaaac aattttactt tttcagaagc tagtcctact atttctaaca cttcttcaat
    12541 tgcattttct ttttgtatac ctaatatttt agcatttata gttaagttct ctttagctgt
    12601 caaattacta taaaaacctg gcgtttcaac catagcacca atatttttta aaatttcagt
    12661 tttattactt tcgaactctt tttcaaatat tttaatatta cctttcgtag gtttaattaa
    12721 gcctaaaagc attcttatag tagttgtttt gcctgcacca tttcttccta aaaaaccata
    12781 aatttgtcca ctttcaacag ttatactcaa attattaact gctatctgac ttccatattg
    12841 ctttgttaag ttatttattt caattatatt attcaaattt ttcacctctg gcacctttct
    12901 tagtttgttg ttacctttat cttacgcgcg attagaaaag gctgccttta tctattctta
    12961 caaaaacagc cgctaatctt acaaaaatga aagattggag ttatttaaat tgaatggtga
    13021 atattgaacc atcgtttaat gtagatgtag cacttacttt atggcctaag cgctttgaga
    13081 ttgtgctgac aatatataaa ccaataccgc ttgatttctc acttattcta ccgttatagc
    13141 ccgagaaacc tttatcaaag attttcggta aatcactcgc attaatgccg ataccgttat
    13201 ctcggattga taatttcttt gtattttcgt caaacgtaat ccacacatct ttgccacgtg
    13261 catattttaa tgcattgttt aatatttgct caatcataat tgatgcccat ttggcatctg
    13321 ttaatataac cgcttcactt ttctcataat gcaactttgt ttgatgatga ataaactgta
    13381 tcgcataacg tttaatcagt ggtcgaatta attcatctac actcacttcc ataaagacca
    13441 tgtatgtctt ttggttcatg agtttcaaat agttcagtgc aagattcgtg taattatcaa
    13501 tttgtaagac ttcattacgc acgttagaaa tcacgtgttc atcaggatct tcaagcagta
    13561 actttgatgc tgtaatcggt gtcttgattt gatgcaccca cattaaaaaa tatgactcta
    13621 actcactttg gtagttaata aagtcattac gaagtttatg gttttcgatt cttaaatctt
    13681 cgttctgttc ctgtagtgtt tattcttttt taaagttcat gtaatggata ccccagtaaa
    13741 tcattgaaac aaacaataca atacctagac caatcatata tgcttgcatc ggcacattat
    13801 acatgaataa tataaagtag aataaagcac aagtaaggat gacaatataa atttcacgtt
    13861 ggattgattt caagaaattc atacgtcacc tacacgatat ccgacatttt tcttcgtttc
    13921 gataaaatct gtaagtccta gtttttgtag ctttttgcgt aaacgtgtaa tgttgacagc
    13981 aagcgtattg tcatcaatga agtgttctga ttcccagcat ttttcgatta acgcattacg
    14041 actgacgaat ttgcccttgt tctggaataa gctatgcatg atttgcaatt cagtgtgtgt
    14101 caggtctatg gtttcttcat taaatttaag ctttgctgca tcaagtagta actcgcaatc
    14161 atctactgtt aaattattaa cttgagtggt gaaatcatac gtgcggcgta atagtgcttg
    14221 aatcttagta attgtaacag tcatattaaa tggctggttc tgttgcaaag taaaaaatat
    14281 agctaatcac taatatatca tgtcagtgtt cgtttaactt gctagcatga tgctaatttc
    14341 gtggcatggg gaaaatccgt agatctgaag agacctacgg ttctttttat atagagcgta
    14401 aatacattca atacctttta aagtattctt tgccgtattg atactttgat atcttgtctt
    14461 tcttacttta atatgacggt gatcttgctc aatgaggtta ttcagatatt tcgatgtaca
    14521 atgacagtca ggtttaagtt taaaagcttt aattatttta gccattgctg ccttcgttga
    14581 aggtgcctga tctgtaacta ccttttgagg cttaccaaat tgtttaatga gacgtttgat
    14641 aaacgcatat gctgaatgat tatctcgttg cttacgcaac caaatatcta atgtatgtcc
    14701 ctctgtatca atggcacgat ataaatagct ccattttcct tttattttga tatacgtctc
    14761 atcaatacgc catttgtaat aagctttttt atgctttttc ttccaaattt gatataaaat
    14821 tggggcatat tcttgaaccc aacggtagat cgttgaatga tgaacgttta caccacgttc
    14881 tcttaatatt tcagatatat cacgatagct caatgcatat cttagatagt agccaacggc
    14941 tacagtgata acatccttgt taaattgttt atatctgaaa tagttcatac agaagactcc
    15001 tttttgttaa aattatatta taaattcaac tttgcaacag aaccgtattt tatgagtaca
    15061 ctctaaatta aggagatgta taatcaatct aaaattgtat ttttatactt ttgttatata
    15121 atctttctac ttagagatat attgtaaaaa aaccaacaaa atgttatatt aacattacta
    15181 ttttatcgat gaaggaggat taaaatgaca gcttctatga gactcaaata aacctttttg
    15241 aatacaaaac taaattaatt caaaaaggct tgtccgcaat acacactcat aggatgactt
    15301 atgtcatttt ttatccttcg ataggaataa taaacgcttt caaatactaa aacatcataa
    15361 taaattttta agtgtttgaa agtgtaatgt gaatgagacg ggagtagcct gtctcatttt
    15421 tttgcgtaca cgtcctttaa atatacaagg agtgtataaa tatggaacaa tatacaatta
    15481 aatttaacca aatcaatcat aaattgacag atttacgatc acttaacatc ggtcatcttt
    15541 acgcttacca atttgaaaaa atagcactta ttggggtaat ggtactggca aaaccacatt
    15601 actaaatatg attgctcaaa aaacaaaacc agaatctgga acagttgaaa cggttggcga
    15661 aattcaatat tttgaacagc ttaacatgga tgtggaaaat gattttaaca cgttagacgg
    15721 tagtttaatg agtgaactcc atatacctat gcatacaacc gacagtatga gtggtggtga
    15781 aaaagcaaaa tataaattag ctaatgtcat atcaaattat agtccgatat tacttttaga
    15841 tgaacctaca aatcacttgg ataaaattgg taaagattat ctgaaaaata ttttaaaata
    15901 ttactatggt actttaatta tagtaagtca tgatagagca cttatagacc aaattgctga
    15961 cacaatttgg gatatacaag aagatggcac aataagagtg tttaaaggta attacacaca
    16021 gtatcaaaat caatatgaac aagaacagtt agaacaacaa cgtcaatatg aacagtatat
    16081 aagtgaaaaa caaagattgt cccaagccag taaagctaaa cgaaatcaag cgcaacaaat
    16141 ggcacaagca tcatcaaaac aaaaaaacaa aagtatagca ccagatcgtt taagtgcatc
    16201 aaaacaaaaa ggcacggttg agaaggctgc tcaaaaacaa gctaagcata ttgaaaaaag
    16261 aatggaacat ttggaagaag ttgaaaaacc acaaagttat catgaattca atttcccaca
    16321 aaataaaatt tatgatatcc ataataatta tccaatcatt gcacaaaatc taacattggt
    16381 taaaggaagt caaaaactgc taacacaagt acgattccaa ataccatatg gcaaaaatat
    16441 agcgctcgta ggtgcaaatg gtgtaggtaa gacaacttta cttgaagcta tttaccacca
    16501 aatagaggga attgattgtt ctcctaaagt gcaaatggca tactatcgtc aacttgctta
    16561 tgaagacatg cgtgacgttt cattattgca atatttaatg gatgaaacgg attcatcaga
    16621 atcattcagt agagctattt taaataactt gggtttaaat gaagcacttg atcgttcttg
    16681 taatgttttg agtggtgggg aaagaacgaa attatcgtta gcagtattat tttcaacgaa
    16741 agcgaatatg ttaattttgg atgaaccaac taatttttta gatattaaaa cattagaagc
    16801 attagaaatg tttatgaata aatatcctgg aatcattttg tttacatcac atgatacaag
    16861 gtttgttaaa catgtatcag ataaaaaatg ggaattaaca ggacaatctc ttcatgatat
    16921 aacttaaaaa ctatacacta atttatattg aatattaggt tcatttatat caatataaaa
    16981 aatacgttca caagaaaaat ataatagaaa taaggatcca ataaaatgac tcgacataat
    17041 gaaattatta aatgtgcaga aaaatatcaa ttacacatcc aacctcaaac aatctcattg
    17101 aatgaatcgg gacttgattt tcaagttgca tttggaaaag ataaacatgg agtagaatgg
    17161 gttttgagac taccaagaag acctgacgtt tataaacgaa caaaacccga aaaacaaacg
    17221 gtagacttct tacagaagaa tgtttcattt gaaataccga agtggaaagt acatgcaaaa
    17281 gaccttattg cttacccaaa acttacaggt aaacccgcag ccacaataga tccagaaata
    17341 caaaattatg tatgggaaat tgaacacaaa ccattaccag aaaactttat taacacatta
    17401 gctgaaacac tcgtagattt acacaacata ccagaagaaa acattaacgt tcagcatata
    17461 aatatcaaaa ccatacaaga aataaaaaat gactttcaaa gaagaatgaa taaagttaaa
    17521 gaaacttatg gcgtatcaga tgaattatgg aacagatgga aacaatggtt agaaaacgac
    17581 gaactatggc ctcgacatgc gaccatgata catggggact tacatccagg acatataatg
    17641 gtagataacc aagcaaacgt cacaggtctc atagactgga ctgaagcaac ccactccgac
    17701 ccatcaatgg actttatagg acaccatcgt gtattcgacg acgaaggatt agagcaactt
    17761 ataacagcat acggtaaagc tggaggtgaa atatggccac gaatgaaaga gcatataata
    17821 gaactcaatg cagtattccc aatgtttatc gctgagtttg ctatggaatc aggagaatcg
    17881 gcgtatgaaa cgatggcatt gaaagagtta ggtatgaaag agtagaactt atattaaaag
    17941 aggcccattt taaagacgaa ggcaatcctg atgaaatttt aaaactgcgt ttaattagtg
    18001 atggtctttg gttttctata atgtattaaa tatctggaca tggaacaaat gcaacaaatg
    18061 gaaagaatcg ttttcgaaat ttctaactcc ttaaatcagg aggataaata aacggtcatt
    18121 ttcattgaaa gcacttatat aaatttcatc aattttaata cctaccgtaa atacatttca
    18181 taagtattaa acagatgatt aaaattttta gttaatttaa atatttatga tagagatgac
    18241 cttcaaatga acggttctgt tacaaagaaa aaatctatat ttatttttag taagttttaa
    18301 ttatagatat gtacactttg agtacaccct aaccatacaa aaagaattgt tgaaattata
    18361 acaattaaaa cgtatgatta gggtgtatat ttattatgga gtgaagatga atgattatag
    18421 gttatgcgag agtatcatcg atagatcaaa atttagaaag acaattggat aatttaaaga
    18481 cgtttggtgt ggagaaaatc tttacagaga aacagtcggg aaagtcagtg gaaaatagac
    18541 ctgtatttca agaagcactc aattttgtca gaatgggaga tcgattcgtt gtggaatcta
    18601 ttgatcgttt aggacgtaac tatgatgaaa ttattgaaac tgtgaattat ttaaaagaaa
    18661 aagacgttca gttaatgatt accagcttac ctatgatgaa tgaagtaatt ggcaatccat
    18721 tactggataa gtttatgaaa gatttaatca ttcaaatatt agcaatggtt tcagaacaag
    18781 agagaaatga aagtaaacgt cgacaagcgc aagggattca agttgcgaag gaaaaaggcg
    18841 tatataaagg gcgcccttta ctttattcac caaatgctaa agacccacag aaacgtgtta
    18901 tttatcatcg cgtggtggaa atgttagaag aaggcaaagc gattagtaag attgcgaaag
    18961 aagttaatat cacaagacaa acagtttata gaattaaaca tgataaggga ttatcttgat
    19021 aaattgattg tcaatgcaaa tgagcgtctc tcacagtgtc tcaaattcca taacatatta
    19081 ttgaattgag attttaataa ttatacaaga aaaaagagta cgagttcgca gctttctata
    19141 tagtaattgt tttactaata aggtgtttta aaatatatta taatgtaaaa agtatttgac
    19201 atttgtatca aaaatattta cactcataaa tgtcaaatac tttttacatt tatgaggtgt
    19261 tataatgaat ttaattcctt ttattattat tttaattttt tcttgtttat ggacggctat
    19321 aactaacaaa tatttacctt cagaaacatt agataaaaaa ggacaacaag atcgatacga
    19381 tgaaagacaa cgtaaaatgt ttattgaaat actggctaaa agttttattt ggattgtata
    19441 ttgtatgtta tttacactag tgcttaaatt tacaggtttg tcaccaagta ttgaaggatc
    19501 ttggttttct caatatccag aaattttctt tataattgta gcactatttc ttatgctgtt
    19561 taattactat actacaaata aaaaatatac atctaaaggt taaattaatg aaaaatagaa
    19621 ttagagaata tagaaaacaa aaaggaattt ctcaagaaac tttaagtaaa gaattaaaag
    19681 tgtctaggca aactattaat gcaatagaaa acaataaata tgatcctaca ttgacattag
    19741 catttaagtt ggcaagattg tttgatacaa ctgtggatga attattttct taaccattca
    19801 tttatcacaa aaagagagtg cgaattcgca ctctcttttt gtgtagtagt actattaaat
    19861 tttgtctcaa taacgaacgt ttataacgca atcatgatga gagtattaat acagttaatt
    19921 atttgaaata ctttagttta cataatcgat gattaccaga agttctcact atataaaaga
    19981 cactaaaatt ttataacttt tagtgcctaa tcaattattt tagctaccaa acaaacgact
    20041 ccaaaacccc tttttaggtt ccgtttcttc actcttttct tctatatcac tatcattgtc
    20101 atttagatta gctggaacgt cttctttttt tgcttcttca ccttgtgtac tttcgtcgct
    20161 ttgacttcca gatatatcct tatattgaat ctctgtttct ttagtttctt cctgatctct
    20221 gttaatattt acaggattag tagtatatgt tttttcttgt gcatcaacgt tttgtctagt
    20281 gttagtagat gtatcaaagg gataattaag gtgtttttct ttttctaatt gattttctaa
    20341 tttttgaatc tttttattac tctctaatgc cagaacttgc tgattttcaa gcaattttga
    20401 tctttcttgc aactcttttc tgtaaaattc aattgttgtt tcatgacgac tttcttgttt
    20461 ttcaatttga ttatttaaag tatcaatctg atttttaagg atttctacta tttgagcatc
    20521 gcttttcgat tcaaaattaa tattatccga cccttttttt tgtttgtctt cagtagtact
    20581 ttcaaaacca tatttctttt tattttcatt tactctttga atgatttttt ctatatcggt
    20641 atcttcttta ataaacgaag tgttttcctg ttttattgtc tctatattca atcgcttaat
    20701 attattaaaa atcgtttgct tactaacccc taattcttca ctcaactttt tcacactttt
    20761 catatcatca accctttata aaatgtttat aaacccttga taaaatatta taagcttata
    20821 atgcttaata ataaagtgat taataaataa aaataaacat ccatcaacct ttttatcaag
    20881 ggtttatgaa aggtttatga tatttatcaa gggtttataa acccttgata aagctatatt
    20941 ttccctttta taagtttatt taaagtgcta taataaactt aatataacaa aaaccccaac
    21001 tactggtaat agtcggggtt tggtaataaa acgtttagaa actgtttatt tatataattt
    21061 tcgatacttg tattatataa tgaataatat cttagtgcaa gcacctaaat cattaaataa
    21121 atgtaaagct aaataaaaac gttttattac ctcttaccaa actaaaatat ggaaagaggt
    21181 tttttgtcat gcaaaatcaa tattttacag tgcaagaaaa ttacaaagaa agattttatc
    21241 aaatccctaa agtattcttt accagtgaaa attataaaaa tctaactaat gatatgaaaa
    21301 tagcctatgc tatcttacgt gatcgcttaa atttatctat taaaaatagc tgggttgatg
    21361 aagatggtaa catttacttt gtttattcaa atgaaaagct aatggaaatc ttaaattgta
    21421 aaaaagaaaa gttaacaaaa ataaaaaaag ggttagaaaa cgatggtcta ctcattcaaa
    21481 aacgacgtgg tttaaataaa ccaaatattc tatatttaat gaaacctatt gtcacagaac
    21541 gtgatattta caaaatagaa aaagaagaaa acgatgttga accttacggc gagaaggaag
    21601 ttcgaaaatc gaacgtccag aagttcgaaa atcgaacgtc cagaagttcg aaaatcgaac
    21661 gtccagaagt tcgaaaatcg aacactaatg atactgactt taatgacatt gactttaatg
    21721 atactgagaa taatgatatg aatgacttga atgatataaa gtacaaaaat gaaattagta
    21781 atcattcaaa tcattcaaat caatttacac ataattttga tgataaagaa atgctattgc
    21841 aagaattcca gaacaactaa ctaattattt attaaaatat gattatagag atttagaaat
    21901 cataaaggct gttattctta aagcaaaaaa atcatttaat tcaaggcatg aagatatgca
    21961 ttacatgtta gaggacattg aggatgaaat attaacttct ttaaaaagac ttaaaaaagc
    22021 tatacatgat agggagttaa aggccaaaag gaaacaatca agtcaatgca agcttattta
    22081 atgcaaacaa ttctaactga acttgaagaa acacatgccc tttatatgcg ccgtaaaaac
    22141 atgaaacaat ataatatctt taatcaataa ttcaaatgat tttataacac tcgaagagac
    22201 atcaaaatat tccgttaaat catctgactt tttaactgat gacgacgaaa aaaatcaaga
    22261 aattgtaagt gatttagaaa aaggtttgta tcgaaaacgt atgttaagtt atggtggatt
    22321 gcttaaacaa aagcataaaa ttttaaactt agacgatgcc gaagatggta atttgattaa
    22381 tacaagtgat gaagataaaa cgacagacga agaaaaaaag cacattcaat taccgcaatt
    22441 tggaatttcg aaaagcaaaa ttattattta agacattagt gataactgat gtcttttttt
    22501 attgtttttc tgtaaaaagt gctgtcttat ttttgtgaca aatgctgtat gtagtgtcac
    22561 aaaagtgtga cactacagct ttgtatgata tcactttaaa ataacttaaa accttggaat
    22621 gtctggcctt gccagatcta tcatttttga atgatagcaa atttccctta tgctcttacg
    22681 gagattttag agttaaatta aaatttctaa gtttttgata agaaaagccc tgcaggaatt
    22741 tagaaaaaca tggggaagtt ttaaagtatt ttatgctaat ttttaaattt gcatgtaaat
    22801 gggcagtatc taaaaaatta gtcactgatt ttgctgaaat ttttgtttgt gaaattagca
    22861 tatatttatt tggctcatat ttgcgtttta agagactgta tagattttta agtacaaaac
    22921 ctatatgatt tgcctctaag tcttcaaaat gcctcttaaa atccaaaata aaagtgttta
    22981 atattgtaat aaggattgct atttttataa aaggagagat atcatgaaga ttaaaacttt
    23041 cgctactttt actcatcgtc aattagataa acaagttaat aggtttttaa agaatgatat
    23101 tcatgtatta gaaattcaaa cacacagtaa ttggttatat atttcagcta ttgtttttta
    23161 tgaggataaa taaggaacat cgtatttatg ccgaaaaaat ttattgatgt tgagaagaac
    23221 cttaactaaa cttgcagacg aatgtcggca tagcgtgagc tattaagccg accattcgac
    23281 aagttttggg attgttaagg gttccgaggc tcaacgtcaa taaaacaatt ggaataaaat
    23341 caacctacag agcatccagc tgcaaatgca gttccgcaaa ctgcttcaca tacaccgccg
    23401 gctattggat ttacgattgc ccatactcac agtagtgagc acatgcataa agtccagcca
    23461 tactacaagc gaatgctttg ccgttccatt tgaatcctgc atatgttacc ggtctgtttt
    23521 ttcaactttt tcagccttat attcaacgta atttttgtta ataagtattt ttccctcttt
    23581 gttttcagtc atacttcttt tttcggcaat gaattttgtg atttttttgt tgtagttatc
    23641 atatattgtt tcagaaacta caatttcttt tgttttttca tttttataag cgttattagc
    23701 tatgtagcca tatgcatttt tatcatttgc ttctgtagct agatatttta atttagaatt
    23761 ttgtcttcta gctttatttt tttaaatcct tcttttttca tttgcttttc gaatttttgc
    23821 atatcttcat ttttattttg caattgttct agaaaactta tttctttctt ggtcatttgt
    23881 gatacttcga tgtttttgct tttcaatttt tctttttgat tttctagtaa agaacttttt
    23941 tgttcttcat ttgcgtaagc attagaaaaa ttcgcgctaa ataccagtag gaacaaggaa
    24001 attattgaaa ataattttat aattttcatt tgatacctcc aagataataa gatattttaa
    24061 ttgtataagt aagcgcttta taaaatcaat atttatttta atatattata aaca
//
