LOCUS       CP051980               25433 bp    DNA     circular BCT 24-SEP-2020
DEFINITION  Staphylococcus aureus strain ER09275.3 plasmid pER09275.3B.2,
            complete sequence.
ACCESSION   CP051980
VERSION     CP051980.1
DBLINK      BioProject: PRJNA470993
            BioSample: SAMN14669402
KEYWORDS    .
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 25433)
  AUTHORS   Caban,A.B., Pak,T., Kumaresh,A., Dupper,A., Chacko,K.,
            Sullivan,M.J., Altman,D.R. and van Bakel,H.
  TITLE     PathoSPOT genomic surveillance reveals prolonged under the radar
            outbreaks of nosocomial methicillin resistant S. aureus bloodstream
            infections
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 25433)
  AUTHORS   Caban,A.B., Pak,T., Kumaresh,A., Dupper,A., Chacko,K.,
            Sullivan,M.J., Altman,D.R. and van Bakel,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2020) Genetics and Genomic Sciences, Icahn School
            of Medicine, One Gustave L. Levy Place Box 1498, New York, NY 10029,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 454.298492932861x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/23/2020 10:22:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 3,031
            CDSs (total)                      :: 2,948
            Genes (coding)                    :: 2,803
            CDSs (with protein)               :: 2,803
            Genes (RNA)                       :: 83
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 108 of 145
            Pseudo Genes (incomplete)         :: 29 of 145
            Pseudo Genes (internal stop)      :: 22 of 145
            Pseudo Genes (multiple problems)  :: 14 of 145
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..25433
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="ER09275.3"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pER09275.3B.2"
                     /geo_loc_name="USA:New York City"
                     /lat_lon="40.7903114 N 73.9528738 W"
                     /collection_date="2017"
                     /collected_by="Mount Sinai Hospital"
     gene            join(24761..25433,1..2)
                     /locus_tag="HIK62_00250"
     CDS             join(24761..25433,1..2)
                     /locus_tag="HIK62_00250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="QOB54200.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            143..778
                     /locus_tag="HIK62_00255"
                     /pseudo=""
     CDS             143..778
                     /locus_tag="HIK62_00255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032491779.1"
                     /note="internal stop; incomplete; partial on complete
                     genome; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside 6-adenylyltransferase"
                     /name="aminoglycoside 6-adenylyltransferase"
     gene            775..1305
                     /gene="sat4"
                     /locus_tag="HIK62_00260"
     ARG             776..1302
                     /name="sat4"
                     /gene="sat4"
                     /gene_name="streptothricin N-acetyltransferase Sat4"
                     /tool="amrfinderplus"
                     /drug_class="STREPTOTHRICIN"
                     /identity="97.78"
                     /coverage="100.0"
     gene            1398..2192
                     /gene="aph(3')-IIIa"
                     /locus_tag="HIK62_00265"
     ARG             1399..2189
                     /name="aph(3')-IIIa"
                     /gene="aph(3')-IIIa"
                     /gene_name="aminoglycoside O-phosphotransferase
                     APH(3')-IIIa"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(2300..2488)
                     /locus_tag="HIK62_00270"
                     /pseudo=""
     CDS             complement(2300..2488)
                     /locus_tag="HIK62_00270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002913594.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            2468..3039
                     /locus_tag="HIK62_00275"
                     /pseudo=""
     CDS             2468..3039
                     /locus_tag="HIK62_00275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001079940.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="HTH domain-containing protein"
                     /name="HTH domain-containing protein"
     gene            complement(3208..3882)
                     /locus_tag="HIK62_00280"
     CDS             complement(3208..3882)
                     /locus_tag="HIK62_00280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="QOB54180.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            4144..4329
                     /locus_tag="HIK62_00285"
     CDS             4144..4329
                     /locus_tag="HIK62_00285"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOB54181.1"
                     /translation="MNKLEKWSLVFIIFTFLSSLALLYFKYNFSSVMPVLSLSILTILI
                     LLTSIITVVSVNDEDT"
                     /name="hypothetical protein"
     gene            complement(4552..5130)
                     /locus_tag="HIK62_00290"
     CDS             complement(4552..5130)
                     /locus_tag="HIK62_00290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="QOB54182.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNKQDLNLLKTLYDNGTPI
                     KTIAEQWQVSRTTIYRYLNKLEAKENKNK"
                     /name="recombinase family protein"
     gene            complement(5394..5774)
                     /gene="blaI"
                     /locus_tag="HIK62_00295"
     ARG             complement(5398..5774)
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.21"
                     /coverage="100.0"
     gene            complement(5764..7521)
                     /gene="blaR1"
                     /locus_tag="HIK62_00300"
     ARG             complement(5768..7521)
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="98.8"
                     /coverage="100.0"
     gene            7628..8473
                     /gene="blaZ"
                     /locus_tag="HIK62_00305"
     ARG             7629..8470
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.29"
                     /coverage="100.0"
     gene            complement(8987..9406)
                     /locus_tag="HIK62_00310"
     CDS             complement(8987..9406)
                     /locus_tag="HIK62_00310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418035.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="QOB54186.1"
                     /translation="MELDNCINYLLSTSQNRVFKHFKSLLSPYNITPAEYGVLNCLINS
                     NLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRTVLINSTNKAKDLWPTL
                     EKKAYQLNNHYFANLTNEETVVFKKILLKINKTTF"
                     /name="MarR family transcriptional regulator"
     gene            9530..10500
                     /locus_tag="HIK62_00315"
                     /pseudo=""
     CDS             9530..10500
                     /locus_tag="HIK62_00315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481285.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /name="oxidoreductase"
     gene            complement(10672..10764)
                     /locus_tag="HIK62_00320"
     CDS             complement(10672..10764)
                     /locus_tag="HIK62_00320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="QOB54187.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(10921..11268)
                     /locus_tag="HIK62_00325"
     CDS             complement(10921..11268)
                     /locus_tag="HIK62_00325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="QOB54188.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNHEGF"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(11287..11904)
                     /gene="cadD"
                     /locus_tag="HIK62_00330"
     ARG             complement(11291..11904)
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(13024..13218)
                     /locus_tag="HIK62_00335"
     CDS             complement(13024..13218)
                     /locus_tag="HIK62_00335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001004925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOB54190.1"
                     /translation="MNENLEKYIKSLPLLGLLISILLIVLFFFILDVDEDLFVVFLYCL
                     LPLIVNLSIYGFYVFVKRK"
                     /name="hypothetical protein"
     gene            13328..14020
                     /locus_tag="HIK62_00340"
     CDS             13328..14020
                     /locus_tag="HIK62_00340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOB54191.1"
                     /translation="MKIIKLFSIISLFLLVFSANFSNAYANEEQKSSLLENQKEKLKSK
                     NIEVSQMTKKEISFLEQLQNKNEDMQKFEKQMKKEGFKKIKLEDKNSKLKYLATEANDK
                     NAYGYIANNAYKNEKTKEIVVSETIYDNYNKKITKFIAEKRSMTENKEGKILINKNYVE
                     YKAEKVDKNRPVTYAGFKWNGKAFACSMAGLYACAHYCGVWAIVNPIAGGVCEAVCGTA
                     FAAGCSVG"
                     /name="hypothetical protein"
     gene            complement(14188..14337)
                     /locus_tag="HIK62_00345"
     CDS             complement(14188..14337)
                     /locus_tag="HIK62_00345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000695367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOB54192.1"
                     /translation="MKIKTFATFTHRQLDKQVNRFLKNDIHVLEIQTHSNWLYISAIVF
                     YEDK"
                     /name="hypothetical protein"
     gene            complement(14884..15200)
                     /locus_tag="HIK62_00350"
                     /pseudo=""
     CDS             complement(14884..15200)
                     /locus_tag="HIK62_00350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002483623.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            complement(15193..16176)
                     /locus_tag="HIK62_00355"
     CDS             complement(15193..16176)
                     /locus_tag="HIK62_00355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="QOB54193.1"
                     /translation="MQNQYFTVQENYKERFYQIPKVFFTSENYKNLTNDMKIAYAILRD
                     RLNLSIKNSWVDEDGNIYFVYSNEKLMEILNCKKEKLTKIKKGLENDGLLIQKRRGLNK
                     PNILYLMKPIVTERDIYKIEKEENDVEPYGEKEVRKSNVQKFENRTSRSSKIERPEVRK
                     SNTNDTDFNDIDFNDTENNDMNDLNDIKYKNEISNHSNHSNQFTHNFDDKEMLLQEFPE
                     QLTNYLLKYDYRDLEIIKAVILKAKKSFNSRHEDMHYMLEDIEDEILTSLKRLKKAIHD
                     RGVKGQKETIKSMQAYLMQTILTELEETHALYMRRKNMKQYNIFNQ"
                     /name="replication initiator protein A"
     gene            16602..17345
                     /locus_tag="HIK62_00360"
     CDS             16602..17345
                     /locus_tag="HIK62_00360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002508633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="QOB54194.1"
                     /translation="MKSVKKLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESTTEDKQKKGSDNINFESKSDAQIVEILKNQIDTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNTR
                     QNVDAQEKTYTTNPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAKKEDVPANLND
                     NDSDIEEKSEETEPKKGFWSRLFGS"
                     /name="DUF536 domain-containing protein"
     gene            complement(17814..18713)
                     /gene="mph(C)"
                     /locus_tag="HIK62_00365"
     ARG             complement(17818..18713)
                     /name="mph(C)"
                     /gene="mph(C)"
                     /gene_name="Mph(C) family macrolide 2'-phosphotransferase"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(18812..20278)
                     /gene="msr(A)"
                     /locus_tag="HIK62_00370"
     ARG             complement(18816..20278)
                     /name="msr(A)"
                     /gene="msr(A)"
                     /gene_name="ABC-F type ribosomal protection protein Msr(A)"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE/STREPTOGRAMIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            20752..21426
                     /locus_tag="HIK62_00375"
     CDS             20752..21426
                     /locus_tag="HIK62_00375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="QOB54197.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            21484..21861
                     /locus_tag="HIK62_00380"
                     /pseudo=""
     CDS             21484..21861
                     /locus_tag="HIK62_00380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000866106.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /name="response regulator transcription factor"
     gene            21858..22739
                     /locus_tag="HIK62_00385"
                     /pseudo=""
     CDS             21858..22739
                     /locus_tag="HIK62_00385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_501406.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /name="HAMP domain-containing histidine kinase"
     gene            22855..23784
                     /locus_tag="HIK62_00390"
     CDS             22855..23784
                     /locus_tag="HIK62_00390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000074567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="QOB54201.1"
                     /translation="MKNLNNIIEINNLTKQYGSQIAVNNLSITVESGQIYGFLGRNGAG
                     KTTTIRMLLGLIKPTKGNIKIFEKEFESNKTEILKNIGAMVETPGFYSNLTAKENLTIN
                     AKILGIQKENAIEEVLEIVGLASEKVKLFKNYSLGMKQRLGIARALLHNPELLILDEPT
                     NGLDPIGIKEIRKLIKDLAQSRNITILISSHILSEIEQLVDKVGIIHNGVLLEEIMYED
                     LKKKNRQFISISVSDEEKVACLLETNFGIYDYKIKENGEFKIYSHIDRQQEINRLLVLN
                     NIDVFQMRVIEDNLETYFEDLVGGGTIG"
                     /name="ABC transporter ATP-binding protein"
     gene            23777..24514
                     /locus_tag="HIK62_00395"
     CDS             23777..24514
                     /locus_tag="HIK62_00395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000369394.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="QOB54198.1"
                     /translation="MDNLLRTEFIKLKRSYMFLISILGTCVAPFMVVVASFISMRTKVP
                     TPNIVFKQLFEEVSLYHMLIIGPPLYGVIIAYLFGREYIEDTLKNLLIIPISRESFLVS
                     KIILLFLWIQTLSVIAWLLTLMLGMLLHFQGLSQSLIIDSFFTFVIGGVLLWILSPPII
                     ILSIYFKNYVPTIVLTIIITLINLMTANSEHRGLFPWAAVGDISRGTLPNTYPFLLSLI
                     IIIVTSIFSVIILFSYFKKTDIS"
                     /name="ABC transporter permease"
     gene            24528..24731
                     /locus_tag="HIK62_00400"
     CDS             24528..24731
                     /locus_tag="HIK62_00400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001627151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP kinase"
                     /protein_id="QOB54199.1"
                     /translation="MGFIEQIKAFILGVVEGLTEFAPVSSTGHMIIVDDMWLNTADDLG
                     SASATTFKVVIQLGGSVAKLNL"
                     /name="UDP kinase"
     ARG             complement(18813..20278)
                     /name="msrA"
                     /gene="msrA"
                     /gene_name="msr-type ABC-F protein"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; streptogramin
                     antibiotic; streptogramin B antibiotic"
                     /identity="98.36"
                     /coverage="100.0"
     ARG             complement(17815..18713)
                     /name="mphC"
                     /gene="mphC"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="98.66"
                     /coverage="100.0"
     ARG             788..1305
                     /name="SAT-4"
                     /gene="SAT-4"
                     /gene_name="streptothricin acetyltransferase (SAT)"
                     /tool="rgi"
                     /drug_class="nucleoside antibiotic"
                     /identity="97.16"
                     /coverage="95.56"
     ARG             180..481
                     /name="aad(6)"
                     /gene="aad(6)"
                     /gene_name="ANT(6)"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="99.0"
                     /coverage="36.23"
     ARG             7629..8473
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="95.37"
                     /coverage="100.0"
     Typing          complement(14681..14828)
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="5.980000000000001e-72"
     Typing          complement(14887..15062)
                     /name="rep_cluster_1017"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="92.697"
                     /coverage="94.0"
                     /evalue="1.04e-65"
     Typing          complement(15194..16176)
                     /name="rep_cluster_2100"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.593"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          16603..17345
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 aaacgaacac tgacatgata tattagtgat tagctatatt ttttactttg caacagaacc
       61 atcattttta ttaaaatact cttttgtaaa atctttctgc tcttcaatgt atttaatttc
      121 tttacctcta aatctattat agctatttga tgattacaat aaaattgatc ttaccttatt
      181 gcccttggaa gagttagata attacctaaa gggcgataaa ttaataaagg ttctaattga
      241 taaagattgt agaattaaaa gggacatagt tccgactgat atagattatc atgtaagaaa
      301 gccaagcgca agggagtatg atgattgctg caatgaattt tggaatgtaa caccttatgt
      361 tattaaagga ttgtgccgta aggaaatttt atttgctatt gatcatttta atcagattgt
      421 tcgccatgag ctgctgagaa tgatatcatg gaaggtcggc atcgaaacag gctttaaatg
      481 aagtgtaggc aagaactata agtttattga aaggtatata tccgaggatt tgtgggagaa
      541 acttttgtcc acctaccgga tggattccta tgaaaacata tgggaagcat tatttctatg
      601 ccatcaattg ttcagggcgg tatccggtga ggtggcggaa aggcttcatt atgcctatcc
      661 ggagtatgat aggaatataa caaaatatac cagggacatg tataaaaaat acactggtaa
      721 aaccggctgc ctggatagca catatgccgc tgatatagaa gagaggcggg aacagtgatt
      781 acagaaatga aagcagggca cctgaaagat atcgataaac ccagcgaacc atttgaggtg
      841 ataggtaaga ttataccgag gtatgaaaac gagaattgga cctttacaga attactctat
      901 gaagcgccat atttaaaaag ctaccaagac gaagaggatg aagaggatga ggaggcagat
      961 tgccttgaat atattgacaa tactgataag ataatatatc tttactacca agacgataaa
     1021 tgcgtcggaa aagttaaact gcgaaaaaat tggaaccggt acgcttatat agaagatatc
     1081 gccgtatgta aggatttcag ggggcaaggc ataggcagcg cgcttatcaa tatatctata
     1141 gaatgggcaa agcataaaaa cttgcatgga ctaatgcttg aaacccagga caataacctt
     1201 atagcttgta aattctatca taattgtggt ttcaaaatcg gctccgtcga tactatgtta
     1261 tacgccaact ttgaaaaagc tgttttctgg tatttaaggt tttagaatgc aaggaacagt
     1321 gaattggagt tcgtcttgtt ataattagct tcttggggta tctttaaata ctgtagaaaa
     1381 gaggaaggaa ataataaatg gctaaaatga gaatatcacc ggaattgaaa aaactgatcg
     1441 aaaaataccg ctgcgtaaaa gatacggaag gaatgtctcc tgctaaggta tataagctgg
     1501 tgggagaaaa tgaaaaccta tatttaaaaa tgacggacag ccggtataaa gggaccacct
     1561 atgatgtgga acgggaaaag gacatgatgc tatggctgga aggaaagctg cctgttccaa
     1621 aggtcctgca ctttgaacgg catgatggct ggagcaatct gctcatgagt gaggccgatg
     1681 gcgtcctttg ctcggaagag tatgaagatg aacaaagccc tgaaaagatt atcgagctgt
     1741 atgcggagtg catcaggctc tttcactcca tcgacatatc ggattgtccc tatacgaata
     1801 gcttagacag ccgcttagcc gaattggatt acttactgaa taacgatctg gccgatgtgg
     1861 attgcgaaaa ctgggaagaa gacactccat ttaaagatcc gcgcgagctg tatgattttt
     1921 taaagacgga aaagcccgaa gaggaacttg tcttttccca cggcgacctg ggagacagca
     1981 acatctttgt gaaagatggc aaagtaagtg gctttattga tcttgggaga agcggcaggg
     2041 cggacaagtg gtatgacatt gccttctgcg tccggtcgat cagggaggat atcggggaag
     2101 aacagtatgt cgagctattt tttgacttac tggggatcaa gcctgattgg gagaaaataa
     2161 aatattatat tttactggat gaattgtttt agtacctaga tttagatgtc taaaaagctt
     2221 taactacaag ctttttagac atctaatctt ttctgaagta catccgcaac tgtccatact
     2281 ctgatgtttt atatcttttc taaaagttcg ctagatagag ttctatatta gagatgtaaa
     2341 gagttttggt gaagaggttt gtgagtatgg cttttataac cagggtgcaa tgagaagcac
     2401 taacagcagc tagcttaaga acgcatagga tatacttttt atggaagtca cagaggagga
     2461 ataaaatttg aacaggatta acagagtaac ctctattctt attcagctgc aatcaaaaaa
     2521 ataattcctg ccaaagaaat tgcacagcga tttaatataa gcttaaggac agtttacaga
     2581 gatatccgga cacttgaaga agccggaata ccaattggat ctgaggccgg aaaaggatat
     2641 tttcttgtag agggcttcct acttccgccg gtaatgttta cagcggcgga agtgggtgca
     2701 ttgattacag cagggaaatt tttaaattgc catggagatg aatcatttat aaaggatttt
     2761 gattcagcta tgtataaaat caaatctatt ttgaagcatg gtgaaaaaaa ctatgcacag
     2821 gagttggaga acagtattaa cgtgtacagc acatctggac agaaaaatac attggcggat
     2881 aacgttattg cagcaattca gactgcaatc tgcaataaaa gggtaatatc aattcaatat
     2941 cctgcatcag gagggcaaga accggaaagc agaatgatag agcctatatc actggggttt
     3001 tatgaacaga actggtactt aatcggtttt gcaggctaag aaatgaatat aggaattttc
     3061 gtgtggatcg gattaaaagc atttgcatag aagaagagct ctgtcaaagc catgatggct
     3121 ctttggaaca aatattaaaa caaatgctgg ttctgttgca aagtaaaaaa atatagctaa
     3181 ccactaattt atcatgtcag tgttcgctta acttgctagc atgatgctaa tttcgtggca
     3241 tggcgaaaat ccgtagatct gaagagacct gcggttcttt ttatatagag cgtaaataca
     3301 ctcaatacct tttaaagtat tctttgctgt attgatactt tgataccttg tctttcttac
     3361 tttaatatga cggtgatctt gctcaatgag gttattcaga tatttcgatg tacaatggca
     3421 gtcaggttta agtttaaaag ctttaattac tttaaccatt gctaccttcg ttgaaggtgc
     3481 ctgatctgta attacctttt gaggtttacc aaattgttta atgagacgtt tgataaacgc
     3541 atatgctgaa tgattatctc gttgcttacg caaccaaata tctaatgtat gtccctctgc
     3601 atcaatggca cgatataaat agctccattt tccttttatt ttgatgtacg tctcatcaat
     3661 acgccatttg taataagctt ttttatgctt tttcttccaa atttgatata aaattggggc
     3721 atattcttga acccaacggt agaccgttga atgatgaacg tttacaccac gttcccttaa
     3781 tatttcagat atatcacgat aactcaatgc atatcttaga tagtagccaa cagctacagt
     3841 gataacatcc ttgttaaatt gtttatatct gaaatagttc atacagaaga ctcctttttg
     3901 ttaaaattat actataaatt caactttgca acagaacctc atttactata tgggcatctc
     3961 tttcattatt aatacaaagc tttgtatctc cgatattagg caaaggtgta aacgaattag
     4021 gtgatactat aggattcaac attatattaa tcgtttcttt aataatgatt atcttcttat
     4081 tttttataaa tcgtagtaaa aatatctcct atgattatat aaaagttcaa agaggtgaag
     4141 ccaatgaata aattagaaaa atggtctttg gtatttatta tttttacatt tctctcttca
     4201 ttagcacttt tatatttcaa atataatttt agttcggtta tgccagtcct aagtctttct
     4261 attttaacta tactaatatt gttgacgagt attattactg tagtttcagt taatgatgaa
     4321 gatacttaaa acgttcatta gtgaaacagg tattatatta aaaaagcgta cgaatttgta
     4381 cgcttttttc ttgtgttatt attaaaatct cataacagga aaatattatg agattttaga
     4441 cgctgtcaga acgtctcttt tacatcgagt gacattgaat caaagtcttt gtatgttaat
     4501 gatatataaa attatttagt agattcatta tagtaagcta gattagttgc tctacttgtt
     4561 tttattctct tttgcctcta atttattgag ataacgataa atagttgtac gtgaaacttg
     4621 ccactgctct gcaattgttt taattggcgt accattatca taaagtgtct taagtaagtt
     4681 taaatcttgt ttatttaatt tttcaggtct acctccatat cggcctctag cacgtgctgc
     4741 aattcgaccg gctgatgatc gctctaaaat taaattacgt tcaaactctg caaatgctgc
     4801 gaataaatga aataataatt gtcctgtaga acttgattta tccatcgtta tattttcttc
     4861 taaactatga aaactcacac ctcgttcgtt aagttcatta actaacgtga ttaaatcctc
     4921 catgttccgt cctagtctat ctaatctcca aacaacaatc gtatctcctg acctcgcaaa
     4981 ttcaattgct ttatctaaac caggtcgctt actttttgaa ccactcatat ggtcattaaa
     5041 tatcttttca caaccatatg tatttaatcg atcctcctgt aaattcaaat tttgtaatcc
     5101 agttgaaact cttgcataac ctattttcaa aatacagacc tcctatatac acctttagtg
     5161 taccataact tgattacgag gtcttttgtg aacatagatt ttttgttggg tttttgaaca
     5221 cataattcta tgtaatacat acttatttag acataaaaag agagtgtaca gaaaatggtt
     5281 attttatgta cactctcatc tttactaata tattttaaat gttattaaca aaactaattt
     5341 aataagagtc aagtatagtt tacatatgta taatgtttga aacatatctc taattacttt
     5401 ttactaatat catttaaaat gtctcgcaat tcttcaattt ctttgttatt taattcttca
     5461 tttttcgcaa aatttagcac taaacttttc atgtcccctc catacagttt attaagaaaa
     5521 gttttagcag ttttcatttt aatatcgtct tctttaatat ttgatgagta aaaataaata
     5581 ttctctgatt tgtatcgttt tataatctct tttttatata gtcttgtgat taatgttcta
     5641 attgttttat cgctaacttc tttatatttt tgaatttcaa ctacaatttc attagctgat
     5701 actgattttt tatcccatat tatattcata acatcccatt cagccataga tatttcaact
     5761 tgcttattgg ccatttaaaa cacccatttc ttttaatatt ttttcactga ttaattcagc
     5821 atttttccca gacgggtttc catctgataa atgtgtagca aaataatact tatcatgatt
     5881 tgtaattacg taacctacaa accacccatt attatacttc ccgtttacta tacctgtacc
     5941 tgttttccca tacagttcat acttttcatt tttcttaatc aataatgaag aagataattg
     6001 attctttgct tttttactaa aatggttatt ttgttccatc atatttttaa aaactattac
     6061 ttgttcaaga ttagatattt tcaaactatc ttccatccaa tagtttttat aacttcccaa
     6121 attttcatta ccataattta attgcttgag ttgagccgca gtatagttct ttggtatttg
     6181 attactaata cgttcgaagt accaattaac tgaattttgc attgctgtat ttaaatcttg
     6241 ttccttattc caagactcga aaggataatg tttatgattc catgacatac gtgaattttt
     6301 atcacttatg atatgacggt caagtccaaa catcgctaaa taaattttat aagttgaatc
     6361 aggagaatat ctttttctac tttctttttc attataaata tagtatttgt ctttcttcat
     6421 gctgtacatg acgaaagatc cactatttga accaaaattt ttactttcat ctaaaatttg
     6481 gtgatcgttc tgtaagggct ttttataatt ataatcagtt atggattgcc ccatcaaaaa
     6541 ctggctttga attactatga gcaaaaaagt aaaaatacaa ataaaaattg gaattaattt
     6601 agactgtttt ttcaaattgg cttcttttat attaattaat cttcttttga gtaatgactt
     6661 tttaccatta aatgaatggc ttaatatatt tttattaaaa aatggaatat ttaatacgga
     6721 gtccataata gattccgcat aagttttaaa ttcatttttg ttaatattat taagaacaaa
     6781 tctatcagct tctacttcat tgtcatgaat tatctttctt tttacaatat gtattaatgg
     6841 attgtaactc ataacaatag agaagatatt aaagataatt aaatgtaaag tatctctatt
     6901 tttagcatga gcatattcat gcagtattat atattttagt cttttatcaa ttacactttt
     6961 aaaatatgaa ctaggaatca aaataatata tttcccatac caaaaagtta ttggagattg
     7021 aatagcctct gcttttcgaa tcacaatatt ttttttatat tgatggttga aaagtatcgt
     7081 atctatttta tttttttcat tttcgtttag ataaagtgac tgtttcttta aatatttaag
     7141 atataataag gctttcaaaa atttaaaact taaaataata actaaaacta tccaaataac
     7201 tgtgcagata ttatcaattg aatcccaatt aaacttatgg atatctgttg tgaactcttg
     7261 aataggtttg gtggtattta tgttatggtt caaatcgtgt gacttacttt caactgtggg
     7321 cgcttgatta ttcacattat taaattttat aaaagagaat ttaattggga taaaaggaat
     7381 taatccagca agcatagtta gataccaaac tttataattt aaactataat taaaatagcg
     7441 ttttaatatg tacctaaaaa atactaacaa tagaaatata aaacaaaagc ttactacgct
     7501 cattattagt aatttagcca ttttgacacc ttctttcaaa tatttataat aaacaattga
     7561 catcaatatt acaattgtaa tattattgat ttataaaaat tacaactgta atatcggagg
     7621 gtttattttg aaaaagttaa tatttttaat tgtaattgct ttagttttaa gtgcatgtaa
     7681 ttcaaacagt tcacatgcca aagagttaaa tgatttagaa aaaaaatata atgctcatat
     7741 tggtgtttat gctttagata ctaaaagtgg taaggaagta aaatttaatt cagataagag
     7801 atttgcctat gcttcgactt caaaagcgat aaatagtgct attttgttag aacaagtacc
     7861 ttataataag ttaaataaaa aaatacatat taacaaagat gatatagttg cttattctcc
     7921 tattttagaa aaatatgtag gaaaagatat cactttaaaa gaacttattg aggcttcaat
     7981 ggcatatagt gataatacag caaacaataa aattataaaa gagatcggtg ggatcaaaaa
     8041 agttaaacaa cgtctaaaag gactaggaga taaagtaaca aatccagtta gatatgagat
     8101 agaattaaat tattattcac caaagagcaa aaaagatact tcaacacctg ctgctttcgg
     8161 taagacttta aataaactta tcgcaaatgg aaaattaagc aaagaaaaca aaaaattctt
     8221 acttgattta atgttaaata ataaaagcgg agatacttta attaaagacg gtgtttcaaa
     8281 agactgtaag gttgctgata aaagtggtca agcaataaca tatgcttcta gaaatgatgt
     8341 tgcttttgtt tatcctaagg gccaatctga acctattgtt ttagtcattt ttacgaataa
     8401 agacaataaa agtgataagc caaatgataa gttgataagt gaaaccgcca agagtgtaat
     8461 gaaggaattt taatattcta aatgcataat aaatactgat atcatcttat agtttgtatt
     8521 atcgttgaca tgtataattt tgatatcaaa aactgatttt ccctctatta ttttcgatat
     8581 ttattttctt aattctcttt aacaaactag aaatattgta tatacaaaaa atcataaata
     8641 atagatgaat agtttaatta taggtattca tcaatcgaaa aagcaacgta tcttatttaa
     8701 agtgcgttgc ttttttctca tttataaggt taaataattc tcatatatca agcaaagtga
     8761 caatagcatt ttacaagtat tttttattgt tcgattaggg taaacctaaa taatacataa
     8821 attatattac aatatgttta ttatagaggc taaagtatct tagaaatttg gatagtaggt
     8881 ttttcgggaa taaaagtata gttggcttta atatataatt aagctaagct atcatttata
     8941 tttactcgat tataattcgc acttcaactt ttttataacg taaaaattaa aacgtagttt
     9001 tatttatctt tagtaatatc tttttaaaca ctacagtttc ttcattagtt aaattagcga
     9061 agtaatgatt attaagttga taggctttct tttctaatgt tggccataag tcttttgctt
     9121 tatttgtact gtttattagc acagttcttc tattttcatt atcagtttga cgtgttatta
     9181 gatccttttt ggacatctta tctaatattc cagatattgt tgaaggttct aaatttaaag
     9241 tattaccaat cgctttaggt gtattcaaat tactattaat caagcaattc aaaacaccat
     9301 attctgctgg agtaatatta tagggactta ataaactttt aaaatgttta aaaactctat
     9361 tctgagaagt actcaacaaa taatttatac aattatctaa ttccacaact aaaacctctc
     9421 ttaaatcatt agtattgact cgcttatcat atcatgataa gttttgtagg aaaatagttt
     9481 tgcaacaaaa acatacttct acaaaacaat tgtgaaagaa ggctaataaa tgttcaatgc
     9541 ggtagtagtg agaaaaagtg catcaaatgt tagttataaa gtagaaaaag ttgatgaatc
     9601 tcatttatcg aagggtgatg tattagtaaa agtggtatac tcttcaataa attataagga
     9661 tatgctagct ttacaatata aaggcggtgt aattagagat tatcctatga ttcctggtat
     9721 agattttgca ggtattgttg aatcaagttc gaatgataag tttaaagaag gcgataatgt
     9781 attagttact ggttatgatg ttggcgtgac acatacaggt ggattttcag aatatgcaca
     9841 agtgcctgga gagtggattg ttcctattcc caagaaatgt ctattaaaga gtctatggta
     9901 tatggcacag ccggttttac ggcagcatta tcaatttttg aactagaaaa atatggaatg
     9961 aatatcaaat cacaacctga aattttagtg tctggggcta caggtggtgt gggcagtgtt
    10021 gctatacaaa ttttacataa aattggatat gaaaatatca ctgctatcgt aagaaaagaa
    10081 aagcaaatag aaatcgcaaa aaaattaggt gcaaaacaag taataataat tgaagatgat
    10141 aataaaccgc ttaaaaaagg tatttttgat tatttcttag atacagtggg gagtaatgta
    10201 acattatacg gtttaaaacg tctaaattat caaggtgttg ctactgtatg tggaaatgta
    10261 gcaggaaatt cacttaacgc taatatatta ccgtttattc ttagaggtat taaattaatt
    10321 ggcattgatt ctgtatatgt tgatcataat atccgtgaag atatatggag taagttagca
    10381 aatgaatgga atataggaaa ttcacttcta tacaatgaaa ttggatttga agaattctat
    10441 aaaacgatag atcagctttt aaaaggacaa catttaggaa gaactatttt aaaagtataa
    10501 gtgtgagtat tcattaatac atttactatt aattcaatca ttttgcattt ctctactaac
    10561 cagtgttata atttatataa cgaaaatgat taacaattaa tgcaccaatc cccacactat
    10621 tgcagtagtg tggggatttt ttcgatgctg gcttataaag tcgcctatta attatttgtt
    10681 gcgtttacta agccaataag tataatacgc aacagcacag ccactgatga ctggtgctat
    10741 gatgtgaacg aaaatgatta gcaaagtaat gcacctcctc tcttcgtcaa ttgacgcctg
    10801 agagataggc gactctatta ttataccatc tgtgaatata caagcatatc tacttccgat
    10861 aagtcgtctt atgttatata actttgtttt ttatagtatc aagacaagaa gaaactcgtt
    10921 tcaaaaaccc tcatgatttt tagagaaaaa ctctcttatt tcatcgtctt taataaaata
    10981 atatgccatc tttccatctt tataaaaatc aagtacctca tttttatata aaagccttaa
    11041 atgatgtgaa gttgaagcaa cactcatttt caatatcaaa gaaatatcac aaacacacaa
    11101 ctcatcttct ttaatcaaag ataatatgat tttcaatttc ttctcatcac aaattttttc
    11161 taaaatgtta agtaatttct tagatttatc atcttctaaa aaacttaaag cattgttaac
    11221 tttatcctca tgtacacaga tcacatcaca agtattttca taactcatat aaaatcacac
    11281 cctaaattaa aatataaatc ctaaaattgt ttgaatagtg tcattttcaa taataataaa
    11341 taaacctaaa gctatataaa taatagccat aatccaacga ctaaatttct caacaatttc
    11401 tccaattcct ggaatattag ctaatttttg tgcagtaaac accaagaaga aaattaaaat
    11461 taaaaagaca aacagagtaa gtaataaatt agtaacactt aatgtcacaa aatacggaac
    11521 aaataaacca atattatcgg cgccacaact tgctatcgta acaattgcaa ccgtaccaac
    11581 taatttagac aatccttttt cattcaattc ttttttagct ctcttttctc cttcacaatc
    11641 atcataaata gccactttaa ttccaagata aattggtatt aaacccaata aacctaatat
    11701 ccacttttct ggaacataat ttaatacaaa agctaaaaac aaactaacta atattaaaat
    11761 aatagaccct aaatattgac caacataaat atctctatat tcttttctag tctttgctct
    11821 agcaaaaaat attaataaaa ttactaataa atcaactgct gtagcaatat aaagaacagc
    11881 agcagcaaca accgtttgaa tcataataca cctcattcaa aaatattttt gaatgtatta
    11941 taacttatat ttttaaataa tcataggtgc tttattccaa ttgctttatt gacgttgagc
    12001 cgagcctcgg aacccttaac aatcccaaaa cttgtcgaat ggtcggctta atagctcacg
    12061 ctatgccgac attcgtctgc aagtttagtt aagggttctt ctcaacatca ataaattttt
    12121 tcggcataaa tgcgtgtcta tgcgtagaca tggagacact tcagaattat ggagtgatta
    12181 catgagttta actatttttc tttattcagt tttaggaagt ttattagcaa attatatcta
    12241 cgaaaaatct tcaaaataaa taactttttc ggttctattt tgtacacttt atctacctgg
    12301 tagacctaat tgttattgct ttacaggtct aaaattcgtc gttataatct agttaaatcc
    12361 cgtaagggcg cacttatacg tcggataaat cgacatgtgc aaaaacgtaa tcgaccttcg
    12421 tcgatttttt tatttcaaaa ttaaagaaac ggcttgagat attccgagca gttataaaaa
    12481 ttaatttgcg ttgaatattg ctactacatt cttgaaaaag tgatgtagat ttatagccca
    12541 taactttttt gaattacatc gacgatacgg cgtcgaaaga aaaataaata gaccgtatga
    12601 aagaaaaagc tacctcactt tatctggggt agcttttatt ttttatgccc ttattttgaa
    12661 ttttaagagg gcattttaaa gatttagggg tgattcatat agttttatat ctaaaactta
    12721 tatatgcttt taaaacgcaa atatgagcca aataaatata tgctattttc aaaaacaaaa
    12781 atttgagcaa aaacaataac tatttttaga cactgcccat ttacatgcaa attaaaaatt
    12841 agcataaaat tctttaaaac ttccccacgt ttttctaaat tcctgtaggg cgtttttatc
    12901 aaaaatcaag acaagaagaa actcgttcac actcgtttca aaaaaacaag aaatctaatc
    12961 tatacaccta ccgttttcca acccctcaaa gcatacaaat taaaaacaaa attattcata
    13021 atcttacttt cttttaacaa aaacataaaa accataaata gacaaattaa ctatcaaagg
    13081 caataaacag tataaaaaaa ccacgaataa atcttcatca acatctaaaa taaaaaagaa
    13141 taaaacaatt aacaaaatac taattaacaa acctaaaagt ggcaaacttt ttatatattt
    13201 ttctaaattt tcattcataa aatagactcc tttcaaaaat atgtttataa atatattaaa
    13261 ataaatattg attttataaa gcgcttactt atacaattaa aatatcttat tatcttggag
    13321 gtatcaaatg aaaattataa aattattttc aataatttcc ttgttcctac tggtatttag
    13381 cgcgaatttt tctaatgctt acgcaaatga agaacaaaaa agttctttac tagaaaatca
    13441 aaaagaaaaa ttgaaaagca aaaacatcga agtatcacaa atgaccaaga aagaaataag
    13501 ttttctagaa caattgcaaa ataaaaatga agatatgcaa aaattcgaaa agcaaatgaa
    13561 aaaagaagga tttaaaaaaa taaagctaga agacaaaaat tctaaattaa aatatctagc
    13621 tacagaagca aatgataaaa atgcatatgg ctacatagct aataacgctt ataaaaatga
    13681 aaaaacaaaa gaaattgtag tttctgaaac aatatatgat aactacaaca aaaaaatcac
    13741 aaaattcatt gccgaaaaaa gaagtatgac tgaaaacaaa gagggaaaaa tacttattaa
    13801 caaaaattac gttgaatata aggctgaaaa agttgataaa aacagaccgg taacatatgc
    13861 aggattcaaa tggaacggca aagcattcgc ttgtagtatg gctggacttt atgcatgtgc
    13921 tcactactgt ggagtatggg caatcgtaaa tccaatagcc ggcggtgtat gtgaagcagt
    13981 ttgcggaact gcatttgcag ctggatgctc tgtaggttga ttttattcca attgttttat
    14041 tgacgttgag cctcggaacc cttaacaatc ccaaaacttg tcgaatggtc ggcttaatag
    14101 ctcacgctat gccgacattc gtctgcaagt ttagttaagg gttcttctca acatcaataa
    14161 attttttcgg cataaatacg atgttcctta tttatcctca taaaaaacaa tagctgaaat
    14221 atataaccaa ttactgtgtg tttgaatttc taatacatga atatcattct ttaaaaacct
    14281 attaacttgt ttatctaatt gacgatgagt aaaagtagcg aaagttttaa tcttcatgat
    14341 atctctcctt ttataaaaat agcaatcctt attacaatat taaacacttt tattttggat
    14401 tttaagaggc attttgaaga cttagaggca aatcatatag gttttgtact taaaaatcta
    14461 tacagtctct taaaacgcaa atatgagcca aataaatata tgctaatttc acaaacaaaa
    14521 atttcagcaa aatcagtgac taatttttta gatactgccc atttacatgc aaatttaaaa
    14581 attagcataa aatactttaa aacttcccca tgtttttcta aattcctgca gggcttttct
    14641 tatcaaaaac ttagaaattt taatttaact ctaaaatctc cgtaagagca taagggaaat
    14701 ttgctatcat tcaaaaatga tagatctggc aaggccagac attccaaggg ttttaagtta
    14761 ttttaaagtg atatcataca aagctgtagt gtcacacttt tgtgacacta catacagcat
    14821 ttgtcacaaa aataagacag cactttttta cagaaaaaca ataaaaaaag acatcagtta
    14881 tcactaatgt cttaaataat aattttgctt ttcgaaattc caaattgcgg taattgaatg
    14941 tgcttttttt cttcgtctgt cgttttatct tcatcacttg tattaatcaa attaccatct
    15001 tcggcatcgt ctaagtttaa aattttatgc ttttgtttaa gcaatccacc ataacttaac
    15061 atacgttttc gatacaaacc tttttctaaa tcacttacaa tttcttgatt tttttcgtcg
    15121 tcatcagtta aaaagtcaga tgatttaacg gaatattttg atgtctcttc gagtgttata
    15181 aaatcatttg aattattgat taaagatatt atattgtttc atgtttttac ggcgcatata
    15241 aagggcatgt gtttcttcaa gttcagttag aattgtttgc attaaataag cttgcattga
    15301 cttgattgtt tccttttggc ctttaactcc cctatcatgt atagcttttt taagtctttt
    15361 taaagaagtt aatatttcat cctcaatgtc ctctaacatg taatgcatat cttcatgcct
    15421 tgaattaaat gatttttttg ctttaagaat aacagccttt atgatttcta aatctctata
    15481 atcatatttt aataaataat tagttagttg ttctgggaat tcttgcaata gcatttcttt
    15541 atcatcaaaa ttatgtgtaa attgatttga atgatttgaa tgattactaa tttcattttt
    15601 gtactttata tcattcaagt cattcatatc attattctca gtatcattaa agtcaatgtc
    15661 attaaagtca gtatcattag tgttcgattt tcgaacttct ggacgttcga ttttcgaact
    15721 tctggacgtt cgattttcga acttctggac gttcgatttt cgaacttcct tctcgccgta
    15781 aggttcaaca tcgttttctt ctttttctat tttgtaaata tcacgttctg tgacaatagg
    15841 tttcattaaa tatagaatat ttggtttatt taaaccacgt cgtttttgaa tgagtagacc
    15901 atcgttttct aacccttttt ttatttttgt taacttttct tttttacaat ttaagatttc
    15961 cattagcttt tcatttgaat aaacaaagta aatgttacca tcttcatcaa cccagctatt
    16021 tttaatagat aaatttaagc gatcacgtaa gatagcatag gctattttca tatcattagt
    16081 tagattttta taattttcac tggtaaagaa tactttaggg atttgataaa atctttcttt
    16141 gtaattttct tgcactgtaa aatattgatt ttgcatgaca aaaaacctct ttccatattt
    16201 tagtttggta agaggtaata aaacgttttt atttagcttt acatttattt aatgatttag
    16261 gtgcttgcac taagatatta ttcattatat aatacaagta tcgaaaatta tataaataaa
    16321 cagtttctaa acgttttatt accaaacccc gactattacc agtagttggg gtttttgtta
    16381 tattaagttt attatagcac tttaaataaa cttataaaag ggaaaatata gctttatcaa
    16441 gggtttataa acccttgata aatatcataa acctttcata aacccttgat aaaaaggttg
    16501 atggatgttt atttttattt attaatcact ttattattaa gcattataag attataatat
    16561 tttatcaagg gtttataaac attttataaa gggttgatga tatgaaaagt gtgaaaaagt
    16621 tgagtgaaga attaggggtt agtaagcaaa cgatttttaa taatattaag cgattgaata
    16681 tagagacaat aaaacaggaa aacacttcgt ttattaaaga agataccgat atagaaaaaa
    16741 tcattcaaag agtaaatgaa aataaaaaga aatatggttt tgaaagtact actgaagaca
    16801 aacaaaaaaa agggtcggat aatattaatt ttgaatcgaa aagcgatgct caaatagtag
    16861 aaatccttaa aaatcagatt gatactttaa ataatcaaat tgaaaaacaa gaaagtcgtc
    16921 atgaaacaac aattgaattt tacagaaaag agttgcaaga aagatcaaaa ttgcttgaaa
    16981 atcagcaagt tctggcatta gagagtaata aaaagattca aaaattagaa aatcaattag
    17041 aaaaagaaaa acaccttaat tatccctttg atacatctac taacactaga caaaacgttg
    17101 atgcacaaga aaaaacatat actactaatc ctgtaaatat taacagagat caggaagaaa
    17161 ctaaagaaac agagattcaa tataaggata tatctggaag tcaaagcgac gaaagtacac
    17221 aaggtgaaga agcaaaaaaa gaagacgttc cagctaatct aaatgacaat gatagtgata
    17281 tagaagaaaa gagtgaagaa acggaaccta aaaaggggtt ttggagtcgt ttgtttggta
    17341 gctaaaataa ttgattaggc actaaaagtt ataaaatttt agtgtctttt atatagtgag
    17401 aacttctggt aatcatcgat tatgtaaact aaagtatttc aaataattaa ctgtattaat
    17461 actctcatca tgattgcgtt ataaacgttc atttgaaggt catctctatc ataaatattt
    17521 aaattaacta aaaattttaa tcatctgttt aatacttatg aaatgtattt acggtaggta
    17581 ttaaaattga tgaaatttat ataagtgctt tcaatgaaaa tgaccgttta tttatcctcc
    17641 tgatttaagg agttagaaat ttcgaaaacg attctttcca tttgttgcat ttgttccatg
    17701 tccagatatt taatacatta tagaaaacca aagaccatca ctaattaaac gcagttttaa
    17761 aatttcatca ggattgcctt cgtctttaaa atgggcctct tttaatataa gttctactct
    17821 ttcataccta actctttcaa tgccatcgtt tcatacgccg attctcctga ttccatagca
    17881 aactcagcga taaacattgg gaatactgca ttgagttcta ttatatgctc tttcattcgt
    17941 ggccatattt cacctccagc tttaccgtat gctgttataa gttgctctaa tccttcgtcg
    18001 tcgaatacac gatggtgtcc tataaagtcc attgatgggt cggagtgggt tgcttcagtc
    18061 cagtctatga gacctgtgac gtttgcttgg ttatctacca ttatatgtcc tggatgtaag
    18121 tccccatgta tcatggtcgc atgtcgaggc catagttcgt cgttttctaa ccattgtttc
    18181 catctgttcc ataattcatc tgatacgcca taagtttctt taactttatt cattcttctt
    18241 tgaaagtcat tttttatttc ttgtatggtt ttgatattta tatgctgaac gttaatgttt
    18301 tcttctggta tgttgtgtaa atctacgagt gtttcagcta atgtgttaat aaagttttct
    18361 ggtaatggtt tgtgttcaat ttcccataca taattttgta tttctggatc tattgtggct
    18421 gcgggtttac ctgtaagttt tgggtaagca ataaggtctt ttgcatgtac tttccacttc
    18481 ggtatttcaa atgaaacatt cttctgtaag aagtctaccg tttgtttttc gggttttgtt
    18541 cgtttataaa cgtcaggtct tcttggtagt ctcaaaaccc attctactcc atgtttatct
    18601 tttccaaatg caacttgaaa atcaagtccc gattcattca atgagattgt ttgaggttgg
    18661 atgtgtaatt gatatttttc tgcacattta ataatttcat tatgtcgagt cattttattg
    18721 gatccttatt tctattatat ttttcttgtg aacgtatttt ttatattgat ataaatgaac
    18781 ctaatattca atataaatta gtgtatagtt tttaagttat atcatgaaga gattgtcctg
    18841 ttaattccca ttttttatct gatacatgtt taacaaacct tgtatcatgt gatgtaaaca
    18901 aaatgattcc aggatattta ttcataaaca tttctaatgc ttctaatgtt ttaatatcta
    18961 aaaaattagt tggttcatcc aaaattaaca tattcgcttt cgttgaaaat aatactgcta
    19021 acgataattt cgttctttcc ccaccactca aaacattaca agaacgatca agtgcttcat
    19081 ttaaacccaa gttatttaaa atagctctac tgaatgattc tgatgaatcc gtttcatcca
    19141 ttaaatattg caataatgaa acgtcacgca tgtcttcata agcaagttga cgatagtatg
    19201 ccatttgcac tttaggagaa caatcaattc cctctatttg gtggtaaata gcttcaagta
    19261 aagttgtctt acctacacca tttgcaccta cgagcgctat atttttgcca tatggtattt
    19321 ggaatcgtac ttgtgttagc agtttttgac ttcctttaac caatgttaga ttttgtgcaa
    19381 tgattggata attattatgg atatcataaa ttttattttg tgggaaattg aattcatgat
    19441 aactttgtgg tttttcaact tcttccaaat gttccattct tttttcaata tgcttagctt
    19501 gtttttgagc agccttctca accgtgcctt tttgttttga tgcacttaaa cgatctggtg
    19561 ctatactttt gtttttttgt tttgatgatg cttgtgccat ttgttgcgct tgatttcgtt
    19621 tagctttact ggcttgggac aatctttgtt tttcacttat atactgttca tattgacgtt
    19681 gttgttctaa ctgttcttgt tcatattgat tttgatactg tgtgtaatta cctttaaaca
    19741 ctcttattgt gccatcttct tgtatatccc aaattgtgtc agcaatttgg tctataagtg
    19801 ctctatcatg acttactata attaaagtac catagtaata ttttaaaata tttttcagat
    19861 aatctttacc aattttatcc aagtgatttg taggttcatc taaaagtaat atcggactat
    19921 aatttgatat gacattagct aatttatatt ttgctttttc accaccactc atactgtcgg
    19981 ttgtatgcat aggtatatgg agttcactca ttaaactacc gtctaacgtg ttaaaatcat
    20041 tttccacatc catgttaagc tgttcaaaat attgaatttc gccaaccgtt tcaactgttc
    20101 cagattctgg ttttgttttt tgagcaatca tatttagtaa tgtggttttg ccagtaccat
    20161 tacccccaat aagtgctatt ttttcaaatt ggtaagcgta aagatgaccg atgttaagtg
    20221 atcgtaaatc tgtcaattta tgattgattt ggttaaattt aattgtatat tgttccatat
    20281 ttatacactc cttgtatatt taaaggacgt gtacgcaaaa aaatgagaca ggctactccc
    20341 gtctcattca cattacactt tcaaacactt aaaaatttat tatgatgttt tagtatttga
    20401 aagcgtttat tattcctatc gaaggataaa aaatgacata agtcatccta tgagtgtgta
    20461 ttgcggacaa gcctttttga attaatttag ttttgtattc aaaaaggttt atttgagtct
    20521 catagaagct gtcattttaa tcctccttca tcgataaaat agtaatgtta atataacatt
    20581 ttgttggttt ttttacaata tatctctaag tagaaagatt atataacaaa agtataaaaa
    20641 tacaatttta gattgattat acatctcctt aatttagagt gtactcataa aatacggttc
    20701 tgttgcaaag ttgaatttat aatataattt taacaaaaag gagtcttctg tatgaactat
    20761 ttcagatata aacaatttaa caaggatgtt atcactgtag ccgttggcta ctatctaaga
    20821 tatgcattga gctatcgtga tatatctgaa atattaagag aacgtggtgt aaacgttcat
    20881 cattcaacga tctaccgttg ggttcaagaa tatgccccaa ttttatatca aatttggaag
    20941 aaaaagcata aaaaagctta ttacaaatgg cgtattgatg agacgtatat caaaataaaa
    21001 ggaaaatgga gctatttata tcgtgccatt gatacagagg gacatacatt agatatttgg
    21061 ttgcgtaagc aacgagataa tcattcagca tatgcgttta tcaaacgtct cattaaacaa
    21121 tttggtaagc ctcaaaaggt agttacagat caggcacctt caacgaaggc agcaatggct
    21181 aaaataatta aagcttttaa acttaaacct gactgtcatt gtacatcgaa atatctgaat
    21241 aacctcattg agcaagatca ccgtcatatt aaagtaagaa agacaagata tcaaagtatc
    21301 aatacggcaa agaatacttt aaaaggtatt gaatgtattt acgctctata taaaaagaac
    21361 cgtaggtctc ttcagatcta cggattttcc ccatgccacg aaattagcat catgctagca
    21421 agttaaacga acactgacat gatatattag tgattagcta tattttttac tttgcaacag
    21481 aaccagccat ttaatatgac tgttacaatt actaagattc aagcactatt acgccgcacg
    21541 tatgatttca ccactcaagt taataattta acagtagatg attgcgagtt actacttgat
    21601 gcagcaaagc ttaaatttaa tgaagaaacc atagacctga cacacactga attgcaaatc
    21661 atgcatagct tattccagaa caagggcaaa ttcgtcagtc gtaatgcgtt aatcgaaaaa
    21721 tgctgggaat cagaacactt cattgatgac aatacgcttg ctgtcaacat tacacgttta
    21781 cgcaaaaagc tacaaaaact aggacttaca gattttatcg aaacgaagaa aaatgtcgga
    21841 tatcgtgtag gtgacgtatg aatttcttga aatcaatcca acgtgaaatt tatattgtca
    21901 tccttacttg tgctttattc tactttatat tattcatgta taatgtgccg atgcaagcat
    21961 atatgattgg tctaggtatt gtattgtttg tttcaatgat ttactggggt atccattaca
    22021 tgaactttaa aaaagaataa acactacagg aacagaacga agatttaaga atcgaaaacc
    22081 ataaacttcg taatgacttt attaactacc aaagtgagtt agagtcatat tttttaatgt
    22141 gggtgcatca aatcaagaca ccgattacag catcaaagtt actgcttgaa gatcctgatg
    22201 aacacgtgat ttctaacgtg cgtaatgaag tcttacaaat tgataattac acgaatcttg
    22261 cactgaacta tttgaaactc atgaaccaaa agacatacat ggtctttatg gaagtgagtg
    22321 tagatgaatt aattcgacca ctgattaaac gttatgcgat acagtttatt catcatcaaa
    22381 caaagttgca ttatgagaaa agtgaagcgg ttatattaac agatgccaaa tgggcatcaa
    22441 ttatgattga gcaaatatta aacaatgcat taaaatatgc acgtggcaaa gatgtgtgga
    22501 ttacgtttga cgaaaataca aagaaattat caatccgaga taacggtatc ggcattaatg
    22561 cgagtgattt accgaaaatc tttgataaag gtttctcggg ctataacggt agaataagtg
    22621 agaaatcaag cggtattggt ttatatattg tcagcacaat ctcaaagcgc ttaggccata
    22681 aagtaagtgc tacatctaca ttaaacgatg gttcaatatt caccattcaa tttaaataac
    22741 tccaatcttt catttttgta agattagcgg ctgtttttgt aagaatagat aaaggcagcc
    22801 ttttctaatc gcgcgtaaga taaaggtaac aacaaactaa gaaaggtgcc agaggtgaaa
    22861 aatttgaata atataattga aataaataac ttaacaaagc aatatggaag tcagatagca
    22921 gttaataatt tgagtataac tgttgaaagt ggacaaattt atggtttttt aggaagaaat
    22981 ggtgcaggca aaacaactac tataagaatg cttttaggct taattaaacc tacgaaaggt
    23041 aatattaaaa tatttgaaaa agagttcgaa agtaataaaa ctgaaatttt aaaaaatatt
    23101 ggtgctatgg ttgaaacgcc aggtttttat agtaatttga cagctaaaga gaacttaact
    23161 ataaatgcta aaatattagg tatacaaaaa gaaaatgcaa ttgaagaagt gttagaaata
    23221 gtaggactag cttctgaaaa agtaaaattg tttaaaaatt attctttagg tatgaagcaa
    23281 cgtttaggga ttgcgagagc tttattgcac aatcccgaat tattgatact tgatgagccg
    23341 acgaatggat tagatcctat tggcataaaa gaaattagaa agttgattaa ggatctggct
    23401 caatctagaa atataaccat tttaatttca agtcatatat tgtcagaaat agagcagtta
    23461 gtagacaagg tgggtattat tcataacgga gttttgttag aagaaattat gtatgaagat
    23521 ttaaaaaaaa agaacagaca atttataagt atatcagtat cagatgaaga aaaagttgca
    23581 tgtttgttgg aaactaactt cggaatttat gactataaaa ttaaagaaaa tggcgaattt
    23641 aaaatttatt cacatattga tagacaacaa gaaattaata gattattagt attaaacaat
    23701 attgatgttt tccagatgag agtgatagaa gataatctag aaacttattt cgaagactta
    23761 gtaggaggtg gcacaattgg ataatctact ccgtacagaa tttattaagt taaaaagatc
    23821 atatatgttt ctaataagta ttttaggtac atgcgtagca ccttttatgg tggttgtagc
    23881 ttcttttatt agtatgcgga cgaaagtacc gactcctaat attgtattta aacagttatt
    23941 tgaagaagtc agtttatatc atatgctaat tattggacct cctctatatg gggttataat
    24001 agcctatttg tttggaagag aatatataga agatacttta aaaaacttat taattatacc
    24061 tatatctaga gaaagttttt tagtaagtaa aataatatta ttattcttgt ggattcaaac
    24121 actatctgtt attgcatggt tgctaacttt aatgctaggt atgctattgc attttcaagg
    24181 gttaagccag agtttaataa ttgattcatt ctttacattt gttattggcg gagtgttatt
    24241 atggatatta tctccaccaa taattatttt gtcgatatat tttaaaaatt atgttcccac
    24301 aattgtttta accataataa ttactttgat aaatttaatg actgctaatt ctgaacatag
    24361 aggattattt ccttgggctg cagttggaga catatctaga ggaacattac ctaatactta
    24421 tccatttcta ttatctttaa ttatcataat tgttacatct atattcagtg taattatatt
    24481 attctcatac tttaaaaaaa ctgatataag ttaaaaggag gagaaaaatg ggttttatag
    24541 agcagattaa agcatttatt ttaggtgtag ttgaagggtt gacagaattt gctccagtat
    24601 catcaacagg tcatatgatt attgttgatg atatgtggtt aaacactgct gacgatttag
    24661 gaagtgcgtc tgcaactact tttaaggtgg taatacagtt aggaggttct gttgcaaagt
    24721 tgaatttata atataatttt aacaaaaagg agtcttctgt atgaactatt tcagatataa
    24781 acaatttaac aaggatgtta tcactgtagc cgttggctac tatctaagat atgcattgag
    24841 ctatcgtgat atatctgaaa tattaagaga acgtggtgta aacgttcatc attcaacgat
    24901 ctaccgttgg gttcaagaat atgccccaat tttatatcaa atttggaaga aaaagcataa
    24961 aaaagcttat tacaaatggc gtattgatga gacgtatatc aaaataaaag gaaaatggag
    25021 ctatttatat cgtgccattg atacagaggg acatacatta gatatttggt tgcgtaagca
    25081 acgagataat cattcagcat atgcgtttat caaacgtctc attaaacaat ttggtaagcc
    25141 tcaaaaggta gttacagatc aggcaccttc aacgaaggca gcaatggcta aaataattaa
    25201 agcttttaaa cttaaacctg actgtcattg tacatcgaaa tatctgaata acctcattga
    25261 gcaagatcac cgtcatatta aagtaagaaa gacaagatat caaagtatca atacggcaaa
    25321 gaatacttta aaaggtattg aatgtattta cgctctatat aaaaagaacc gtaggtctct
    25381 tcagatctac ggattttccc catgccacga aattagcatc atgctagcaa gtt
//
