LOCUS       CP051956               24130 bp    DNA     circular BCT 24-SEP-2020
DEFINITION  Staphylococcus aureus strain ER09835.3 plasmid pER09835.3A.1,
            complete sequence.
ACCESSION   CP051956
VERSION     CP051956.1
DBLINK      BioProject: PRJNA470993
            BioSample: SAMN14669414
KEYWORDS    .
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 24130)
  AUTHORS   Caban,A.B., Pak,T., Kumaresh,A., Dupper,A., Chacko,K.,
            Sullivan,M.J., Altman,D.R. and van Bakel,H.
  TITLE     PathoSPOT genomic surveillance reveals prolonged under the radar
            outbreaks of nosocomial methicillin resistant S. aureus bloodstream
            infections
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 24130)
  AUTHORS   Caban,A.B., Pak,T., Kumaresh,A., Dupper,A., Chacko,K.,
            Sullivan,M.J., Altman,D.R. and van Bakel,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2020) Genetics and Genomic Sciences, Icahn School
            of Medicine, One Gustave L. Levy Place Box 1498, New York, NY 10029,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 484.089509896324x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/23/2020 09:52:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 2,935
            CDSs (total)                      :: 2,853
            Genes (coding)                    :: 2,797
            CDSs (with protein)               :: 2,797
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 56
            CDSs (without protein)            :: 56
            Pseudo Genes (ambiguous residues) :: 0 of 56
            Pseudo Genes (frameshifted)       :: 32 of 56
            Pseudo Genes (incomplete)         :: 24 of 56
            Pseudo Genes (internal stop)      :: 14 of 56
            Pseudo Genes (multiple problems)  :: 14 of 56
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..24130
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="ER09835.3"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pER09835.3A.1"
                     /geo_loc_name="USA:New York City"
                     /lat_lon="40.7903114 N 73.9528738 W"
                     /collection_date="2017"
                     /collected_by="Mount Sinai Hospital"
     gene            join(23161..24130,1..2)
                     /locus_tag="HIK74_00005"
     CDS             join(23161..24130,1..2)
                     /locus_tag="HIK74_00005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="QOB20701.1"
                     /translation="MFNAVVVRKSASNVSYKVEKVDESHLSKGDVLVKVVYSSINYKDM
                     LALQYKGGVIRDYPMIPGIDFAGIVESSSNDKFKEGDNVLVTGYDVGVTHTGGFSEYAQ
                     VPGEWIVPIPQEMSIKESMVYGTAGFTAALSIFELEKYGMNIKSQPEILVSGATGGVGS
                     VAIQILHKIGYENITAIVRKEKQIEIAKKLGAKQVIIIEDDNKPLKKGIFDYFLDTVGS
                     NVTLYGLKRLNYQGVATVCGNVAGNSLNANILPFILRGIKLIGIDSVYVDHNIREDIWS
                     KLANEWNIGNSLLYNEIGFEEFYKTIDQLLKGQHLGRTILKV"
                     /name="oxidoreductase"
     gene            complement(174..266)
                     /locus_tag="HIK74_00010"
     CDS             complement(174..266)
                     /locus_tag="HIK74_00010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="QOB20676.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(423..770)
                     /locus_tag="HIK74_00015"
     CDS             complement(423..770)
                     /locus_tag="HIK74_00015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="QOB20677.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNHEGF"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(789..1406)
                     /gene="cadD"
                     /locus_tag="HIK74_00020"
     ARG             complement(793..1406)
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(2522..2716)
                     /locus_tag="HIK74_00025"
     CDS             complement(2522..2716)
                     /locus_tag="HIK74_00025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001004925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOB20679.1"
                     /translation="MNENLEKYIKSLPLLGLLISILLIVLFFFILDVDEDLFVVFLYCL
                     LPLIVNLSIYGFYVFVKRK"
                     /name="hypothetical protein"
     gene            2826..3518
                     /locus_tag="HIK74_00030"
     CDS             2826..3518
                     /locus_tag="HIK74_00030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOB20680.1"
                     /translation="MKIIKLFSIISLFLLVFSANFSNAYANEEQKSSLLENQKEKLKSK
                     NIEVSQMTKKEISFLEQLQNKNEDMQKFEKQMKKEGFKKIKLEDKNSKLKYLATEANDK
                     NAYGYIANNAYKNEKTKEIVVSETIYDNYNKKITKFIAEKRSMTENKEGKILINKNYVE
                     YKAEKVDKNRPVTYAGFKWNGKAFACSMAGLYACAHYCGVWAIVNPIAGGVCEAVCGTA
                     FAAGCSVG"
                     /name="hypothetical protein"
     gene            complement(3686..3835)
                     /locus_tag="HIK74_00035"
     CDS             complement(3686..3835)
                     /locus_tag="HIK74_00035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000695367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOB20681.1"
                     /translation="MKIKTFATFTHRQLDKQVNRFLKNDIHVLEIQTHSNWLYISAIVF
                     YEDK"
                     /name="hypothetical protein"
     gene            complement(4382..4698)
                     /locus_tag="HIK74_00040"
                     /pseudo=""
     CDS             complement(4382..4698)
                     /locus_tag="HIK74_00040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002483623.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            complement(4691..5674)
                     /locus_tag="HIK74_00045"
     CDS             complement(4691..5674)
                     /locus_tag="HIK74_00045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="QOB20682.1"
                     /translation="MQNQYFTVQENYKERFYQIPKVFFTSENYKNLTNDMKIAYAILRD
                     RLNLSIKNSWVDEDGNIYFVYSNEKLMEILNCKKEKLTKIKKGLENDGLLIQKRRGLNK
                     PNILYLMKPIVTERDIYKIEKEENDVEPYGEKEVRKSNVQKFENRTSRSSKIERPEVRK
                     SNTNDTDFNDIDFNDTENNDMNDLNDIKYKNEISNHSNHSNQFTHNFDDKEMLLQEFPE
                     QLTNYLLKYDYRDLEIIKAVILKAKKSFNSRHEDMHYMLEDIEDEILTSLKRLKKAIHD
                     RGVKGQKETIKSMQAYLMQTILTELEETHALYMRRKNMKQYNIFNQ"
                     /name="replication initiator protein A"
     gene            6100..6843
                     /locus_tag="HIK74_00050"
     CDS             6100..6843
                     /locus_tag="HIK74_00050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002508633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="QOB20683.1"
                     /translation="MKSVKKLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESTTEDKQKKGSDNINFESKSDAQIVEILKNQIDTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNTR
                     QNVDAQEKTYTTNPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAKKEDVPANLND
                     NDSDIEEKSEETEPKKGFWSRLFGS"
                     /name="DUF536 domain-containing protein"
     gene            complement(7070..7255)
                     /locus_tag="HIK74_00055"
     CDS             complement(7070..7255)
                     /locus_tag="HIK74_00055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016912974.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="QOB20684.1"
                     /translation="MKNRIREYRKQKGISQETLSKELKVSRQTINAIENNKYDPTLTLA
                     FKLARLFDTTVDELFS"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(7260..7598)
                     /locus_tag="HIK74_00060"
     CDS             complement(7260..7598)
                     /locus_tag="HIK74_00060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001049146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOB20685.1"
                     /translation="MNLIPFIIILIFSCLWTAITNKYLPSETLDKKGQQDRYDERQRKM
                     FIEILAKSFIWIVYCMLFTLVLKFTGLSPSIEGSWFSQYPEIFFIIVALFLMLFNYYTT
                     NKKYTSKG"
                     /name="hypothetical protein"
     gene            complement(7844..8452)
                     /locus_tag="HIK74_00065"
     CDS             complement(7844..8452)
                     /locus_tag="HIK74_00065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002474535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="QOB20686.1"
                     /translation="MIIGYARVSSIDQNLERQLDNLKTFGVEKIFTEKQSGKSVENRPV
                     FQEALNFVRMGDRFVVESIDRLGRNYDEIIETVNYLKEKDVQLMITSLPMMNEVIGNPL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRV
                     IYHRVVEMLEEGKAISKIAKEVNITRQTVYRIKHDKGLS"
                     /name="recombinase family protein"
     gene            complement(8938..9837)
                     /gene="mph(C)"
                     /locus_tag="HIK74_00070"
     ARG             complement(8942..9837)
                     /name="mph(C)"
                     /gene="mph(C)"
                     /gene_name="Mph(C) family macrolide 2'-phosphotransferase"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(9936..11402)
                     /gene="msr(A)"
                     /locus_tag="HIK74_00075"
     ARG             complement(9940..11402)
                     /name="msr(A)"
                     /gene="msr(A)"
                     /gene_name="ABC-F type ribosomal protection protein Msr(A)"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE/STREPTOGRAMIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            11881..12555
                     /locus_tag="HIK74_00080"
     CDS             11881..12555
                     /locus_tag="HIK74_00080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="QOB20689.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            12613..12990
                     /locus_tag="HIK74_00085"
                     /pseudo=""
     CDS             12613..12990
                     /locus_tag="HIK74_00085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000866106.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /name="response regulator transcription factor"
     gene            12987..13868
                     /locus_tag="HIK74_00090"
                     /pseudo=""
     CDS             12987..13868
                     /locus_tag="HIK74_00090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_501406.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /name="HAMP domain-containing histidine kinase"
     gene            13984..14913
                     /locus_tag="HIK74_00095"
     CDS             13984..14913
                     /locus_tag="HIK74_00095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000074567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="QOB20690.1"
                     /translation="MKNLNNIIEINNLTKQYGSQIAVNNLSITVESGQIYGFLGRNGAG
                     KTTTIRMLLGLIKPTKGNIKIFEKEFESNKTEILKNIGAMVETPGFYSNLTAKENLTIN
                     AKILGIQKENAIEEVLEIVGLASEKVKLFKNYSLGMKQRLGIARALLHNPELLILDEPT
                     NGLDPIGIKEIRKLIKDLAQSRNITILISSHILSEIEQLVDKVGIIHNGVLLEEIMYED
                     LKKKNRQFISISVSDEEKVACLLETNFGIYDYKIKENGEFKIYSHIDRQQEINRLLVLN
                     NIDVFQMRVIEDNLETYFEDLVGGGTIG"
                     /name="ABC transporter ATP-binding protein"
     gene            14906..15643
                     /locus_tag="HIK74_00100"
     CDS             14906..15643
                     /locus_tag="HIK74_00100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000369394.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="QOB20691.1"
                     /translation="MDNLLRTEFIKLKRSYMFLISILGTCVAPFMVVVASFISMRTKVP
                     TPNIVFKQLFEEVSLYHMLIIGPPLYGVIIAYLFGREYIEDTLKNLLIIPISRESFLVS
                     KIILLFLWIQTLSVIAWLLTLMLGMLLHFQGLSQSLIIDSFFTFVIGGVLLWILSPPII
                     ILSIYFKNYVPTIVLTIIITLINLMTANSEHRGLFPWAAVGDISRGTLPNTYPFLLSLI
                     IIIVTSIFSVIILFSYFKKTDIS"
                     /name="ABC transporter permease"
     gene            15657..15860
                     /locus_tag="HIK74_00105"
     CDS             15657..15860
                     /locus_tag="HIK74_00105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001627151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP kinase"
                     /protein_id="QOB20692.1"
                     /translation="MGFIEQIKAFILGVVEGLTEFAPVSSTGHMIIVDDMWLNTADDLG
                     SASATTFKVVIQLGGSVAKLNL"
                     /name="UDP kinase"
     gene            15890..16564
                     /locus_tag="HIK74_00110"
     CDS             15890..16564
                     /locus_tag="HIK74_00110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="QOB20693.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            16694..16765
                     /locus_tag="HIK74_00115"
                     /pseudo=""
     CDS             16694..16765
                     /locus_tag="HIK74_00115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032491779.1"
                     /note="internal stop; incomplete; partial on complete
                     genome; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside 6-adenylyltransferase"
                     /name="aminoglycoside 6-adenylyltransferase"
     gene            complement(16827..17501)
                     /locus_tag="HIK74_00120"
     CDS             complement(16827..17501)
                     /locus_tag="HIK74_00120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="QOB20694.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            17763..17948
                     /locus_tag="HIK74_00125"
     CDS             17763..17948
                     /locus_tag="HIK74_00125"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOB20695.1"
                     /translation="MNKLEKWSLVFIIFTFLSSLALLYFKYNFSSVMPVLSLSILTILI
                     LLTSIITVVSVNDEDT"
                     /name="hypothetical protein"
     gene            complement(18171..18749)
                     /locus_tag="HIK74_00130"
     CDS             complement(18171..18749)
                     /locus_tag="HIK74_00130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="QOB20696.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNKQDLNLLKTLYDNGTPI
                     KTIAEQWQVSRTTIYRYLNKLEAKENKNK"
                     /name="recombinase family protein"
     gene            complement(19013..19393)
                     /gene="blaI"
                     /locus_tag="HIK74_00135"
     ARG             complement(19017..19393)
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="98.41"
                     /coverage="100.0"
     gene            complement(19383..21140)
                     /gene="blaR1"
                     /locus_tag="HIK74_00140"
     ARG             complement(19387..21140)
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="95.38"
                     /coverage="100.0"
     gene            21247..22092
                     /gene="blaZ"
                     /locus_tag="HIK74_00145"
     ARG             21248..22089
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(22618..23037)
                     /locus_tag="HIK74_00150"
     CDS             complement(22618..23037)
                     /locus_tag="HIK74_00150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418035.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="QOB20700.1"
                     /translation="MELDNCINYLLSTSQNRVFKHFKSLLSPYNITPAEYGVLNCLINS
                     NLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRTVLINSTNKAKDLWPTL
                     EKKAYQLNNHYFANLTNEETVVFKKILLKINKTTF"
                     /name="MarR family transcriptional regulator"
     ARG             complement(9937..11402)
                     /name="msrA"
                     /gene="msrA"
                     /gene_name="msr-type ABC-F protein"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; streptogramin
                     antibiotic; streptogramin B antibiotic"
                     /identity="98.36"
                     /coverage="100.0"
     ARG             complement(8939..9837)
                     /name="mphC"
                     /gene="mphC"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="98.66"
                     /coverage="100.0"
     ARG             21248..22092
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.8"
                     /coverage="100.0"
     Typing          complement(4179..4326)
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="5.980000000000001e-72"
     Typing          complement(4385..4560)
                     /name="rep_cluster_1017"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="92.697"
                     /coverage="94.0"
                     /evalue="1.04e-65"
     Typing          complement(4692..5674)
                     /name="rep_cluster_2100"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.593"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          6101..6843
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 aagtgtgagt attcattaat acatttacta ttaattcaat cattttgcat ttctctacta
       61 accagtgtta taatttatat aacgaaaatg attaacaatt aatgcaccaa tccccacact
      121 attgcagtag tgtggggatt ttttcgatgc tggcttataa agtcgcctat taattatttg
      181 ttgcgtttac taagccaata agtataatac gcaacagcac agccactgat gactggtgct
      241 atgatgtgaa cgaaaatgat tagcaaagta atgcacctcc tctcttcgtc aattgacgcc
      301 tgagagatag gcgactctat tattatacca tctgtgaata tacaagcata tctacttccg
      361 ataagtcgtc ttatgttata taactttgtt ttttatagta tcaagacaag aagaaactcg
      421 tttcaaaaac cctcatgatt tttagagaaa aactctctta tttcatcgtc tttaataaaa
      481 taatatgcca tctttccatc tttataaaaa tcaagtacct catttttata taaaagcctt
      541 aaatgatgtg aagttgaagc aacactcatt ttcaatatca aagaaatatc acaaacacac
      601 aactcatctt ctttaatcaa agataatatg attttcaatt tcttctcatc acaaattttt
      661 tctaaaatgt taagtaattt cttagattta tcatcttcta aaaaacttaa agcattgtta
      721 actttatcct catgtacaca gatcacatca caagtatttt cataactcat ataaaatcac
      781 accctaaatt aaaatataaa tcctaaaatt gtttgaatag tgtcattttc aataataata
      841 aataaaccta aagctatata aataatagcc ataatccaac gactaaattt ctcaacaatt
      901 tctccaattc ctggaatatt agctaatttt tgtgcagtaa acaccaagaa gaaaattaaa
      961 attaaaaaga caaacagagt aagtaataaa ttagtaacac ttaatgtcac aaaatacgga
     1021 acaaataaac caatattatc ggcgccacaa cttgctatcg taacaattgc aaccgtacca
     1081 actaatttag acaatccttt ttcattcaat tcttttttag ctctcttttc tccttcacaa
     1141 tcatcataaa tagccacttt aattccaaga taaattggta ttaaacccaa taaacctaat
     1201 atccactttt ctggaacata atttaataca aaagctaaaa acaaactaac taatattaaa
     1261 ataatagacc ctaaatattg accaacataa atatctctat attcttttct agtctttgct
     1321 ctagcaaaaa atattaataa aattactaat aaatcaactg ctgtagcaat ataaagaaca
     1381 gcagcagcaa caaccgtttg aatcataata cacctcattc aaaaatattt ttgaatgtat
     1441 tataacttat atttttaaat aatcataggt gctttattcc aattgcttta ttgacgttga
     1501 gcctcggaac ccttaacaat cccaaaactt gtcgaatggt cggcttaata gctcacgcta
     1561 tgccgacatt cgtctgcaag tttagttaag ggttcttctc aacatcaata aattttttcg
     1621 gcataaatgc gtgtctatgc gtagacatgg agacacttca gaattatgga gtgattacat
     1681 gagtttaact atttttcttt attcagtttt aggaagttta ttagcaaatt atatctacga
     1741 aaaatcttca aaataaataa ctttttcggt tctactttgt acactttatc tacctggtag
     1801 acctaattgt tattgcttta caggtctaaa attcgtcgtt ataatctagt taaatcccgt
     1861 aagggcgcac ttatacgtcg gataaatcga catgtgcaaa aacgtaatcg accttcgtcg
     1921 atttttttat ttcaaaatta aagaaacggc ttgagatatt ccgagcagtt ataaaaatta
     1981 atttgcgttg aatattgcta ctacattctt gaaaaagtga tgtagattta tagcccataa
     2041 cttttttgaa ttacatcgac gatacggcgt cgaaagaaaa ataaatagac cgtatgaaag
     2101 aaaaagctac ctcactttat ctggggtagc ttttattttt tatgccctta ttttgaattt
     2161 taagagggca ttttaaagat ttaggggtga ttcatatagt tttatatcta aaacttatat
     2221 atgcttttaa aacgcaaata tgagccaaat aaatatatgc tattttcaaa aacaaaaatt
     2281 tgagcaaaaa caataactat ttttagacac tgcccattta catgcaaatt aaaaattagc
     2341 ataaaattct ttaaaacttc cccacgtttt tctaaattcc tgtagggcgt ttttatcaaa
     2401 aatcaagaca agaagaaact cgttcacact cgtttcaaaa aaacaagaaa tctaatctat
     2461 acacctaccg ttttccaacc ccctcaaagc atacaaatta aaaacaaaat tattcataat
     2521 cttactttct tttaacaaaa acataaaaac cataaataga caaattaact atcaaaggca
     2581 ataaacagta taaaaaaacc acgaataaat cttcatcaac atctaaaata aaaaagaata
     2641 aaacaattaa caaaatacta attaacaaac ctaaaagtgg caaacttttt atatattttt
     2701 ctaaattttc attcataaaa tagactcctt tcaaaaatat gtttataaat atattaaaat
     2761 aaatattgat tttataaagc gcttacttat acaattaaaa tatcttatta tcttggaggt
     2821 atcaaatgaa aattataaaa ttattttcaa taatttcctt gttcctactg gtatttagcg
     2881 cgaatttttc taatgcttac gcaaatgaag aacaaaaaag ttctttacta gaaaatcaaa
     2941 aagaaaaatt gaaaagcaaa aacatcgaag tatcacaaat gaccaagaaa gaaataagtt
     3001 ttctagaaca attgcaaaat aaaaatgaag atatgcaaaa attcgaaaag caaatgaaaa
     3061 aagaaggatt taaaaaaata aagctagaag acaaaaattc taaattaaaa tatctagcta
     3121 cagaagcaaa tgataaaaat gcatatggct acatagctaa taacgcttat aaaaatgaaa
     3181 aaacaaaaga aattgtagtt tctgaaacaa tatatgataa ctacaacaaa aaaatcacaa
     3241 aattcattgc cgaaaaaaga agtatgactg aaaacaaaga gggaaaaata cttattaaca
     3301 aaaattacgt tgaatataag gctgaaaaag ttgataaaaa cagaccggta acatatgcag
     3361 gattcaaatg gaacggcaaa gcattcgctt gtagtatggc tggactttat gcatgtgctc
     3421 actactgtgg agtatgggca atcgtaaatc caatagccgg cggtgtatgt gaagcagttt
     3481 gcggaactgc atttgcagct ggatgctctg taggttgatt ttattccaat tgttttattg
     3541 acgttgagcc tcggaaccct taacaatccc aaaacttgtc gaatggtcgg cttaatagct
     3601 cacgctatgc cgacattcgt ctgcaagttt agttaagggt tcttctcaac atcaataaat
     3661 tttttcggca taaatacgat gttccttatt tatcctcata aaaaacaata gctgaaatat
     3721 ataaccaatt actgtgtgtt tgaatttcta atacatgaat atcattcttt aaaaacctat
     3781 taacttgttt atctaattga cgatgagtaa aagtagcgaa agttttaatc ttcatgatat
     3841 ctctcctttt ataaaaatag caatccttat tacaatatta aacactttta ttttggattt
     3901 taagaggcat tttgaagact tagaggcaaa tcatataggt tttgtactta aaaatctata
     3961 cagtctctta aaacgcaaat atgagccaaa taaatatatg ctaatttcac aaacaaaaat
     4021 ttcagcaaaa tcagtgacta attttttaga tactgcccat ttacatgcaa atttaaaaat
     4081 tagcataaaa tactttaaaa cttccccatg tttttctaaa ttcctgcagg gcttttctta
     4141 tcaaaaactt agaaatttta atttaactct aaaatctccg taagagcata agggaaattt
     4201 gctatcattc aaaaatgata gatctggcaa ggccagacat tccaagggtt ttaagttatt
     4261 ttaaagtgat atcatacaaa gctgtagtgt cacacttttg tgacactaca tacagcattt
     4321 gtcacaaaaa taagacagca cttttttaca gaaaaacaat aaaaaaagac atcagttatc
     4381 actaatgtct taaataataa ttttgctttt cgaaattcca aattgcggta attgaatgtg
     4441 ctttttttct tcgtctgtcg ttttatcttc atcacttgta ttaatcaaat taccatcttc
     4501 ggcatcgtct aagtttaaaa ttttatgctt ttgtttaagc aatccaccat aacttaacat
     4561 acgttttcga tacaaacctt tttctaaatc acttacaatt tcttgatttt tttcgtcgtc
     4621 atcagttaaa aagtcagatg atttaacgga atattttgat gtctcttcga gtgttataaa
     4681 atcatttgaa ttattgatta aagatattat attgtttcat gtttttacgg cgcatataaa
     4741 gggcatgtgt ttcttcaagt tcagttagaa ttgtttgcat taaataagct tgcattgact
     4801 tgattgtttc cttttggcct ttaactcccc tatcatgtat agctttttta agtcttttta
     4861 aagaagttaa tatttcatcc tcaatgtcct ctaacatgta atgcatatct tcatgccttg
     4921 aattaaatga tttttttgct ttaagaataa cagcctttat gatttctaaa tctctataat
     4981 catattttaa taaataatta gttagttgtt ctgggaattc ttgcaatagc atttctttat
     5041 catcaaaatt atgtgtaaat tgatttgaat gatttgaatg attactaatt tcatttttgt
     5101 actttatatc attcaagtca ttcatatcat tattctcagt atcattaaag tcaatgtcat
     5161 taaagtcagt atcattagtg ttcgattttc gaacttctgg acgttcgatt ttcgaacttc
     5221 tggacgttcg attttcgaac ttctggacgt tcgattttcg aacttccttc tcgccgtaag
     5281 gttcaacatc gttttcttct ttttctattt tgtaaatatc acgttctgtg acaataggtt
     5341 tcattaaata tagaatattt ggtttattta aaccacgtcg tttttgaatg agtagaccat
     5401 cgttttctaa cccttttttt atttttgtta acttttcttt tttacaattt aagatttcca
     5461 ttagcttttc atttgaataa acaaagtaaa tgttaccatc ttcatcaacc cagctatttt
     5521 taatagataa atttaagcga tcacgtaaga tagcataggc tattttcata tcattagtta
     5581 gatttttata attttcactg gtaaagaata ctttagggat ttgataaaat ctttctttgt
     5641 aattttcttg cactgtaaaa tattgatttt gcatgacaaa aaacctcttt ccatatttta
     5701 gtttggtaag aggtaataaa acgtttttat ttagctttac atttatttaa tgatttaggt
     5761 gcttgcacta agatattatt cattatataa tacaagtatc gaaaattata taaataaaca
     5821 gtttctaaac gttttattac caaaccccga ctattaccag tagttggggt ttttgttata
     5881 ttaagtttat tatagcactt taaataaact tataaaaggg aaaatatagc tttatcaagg
     5941 gtttataaac ccttgataaa tatcataaac ctttcataaa cccttgataa aaaggttgat
     6001 ggatgtttat ttttatttat taatcacttt attattaagc attataagct tataatattt
     6061 tatcaagggt ttataaacat tttataaagg gttgatgata tgaaaagtgt gaaaaagttg
     6121 agtgaagaat taggggttag taagcaaacg atttttaata atattaagcg attgaatata
     6181 gagacaataa aacaggaaaa cacttcgttt attaaagaag ataccgatat agaaaaaatc
     6241 attcaaagag taaatgaaaa taaaaagaaa tatggttttg aaagtactac tgaagacaaa
     6301 caaaaaaaag ggtcggataa tattaatttt gaatcgaaaa gcgatgctca aatagtagaa
     6361 atccttaaaa atcagattga tactttaaat aatcaaattg aaaaacaaga aagtcgtcat
     6421 gaaacaacaa ttgaatttta cagaaaagag ttgcaagaaa gatcaaaatt gcttgaaaat
     6481 cagcaagttc tggcattaga gagtaataaa aagattcaaa aattagaaaa tcaattagaa
     6541 aaagaaaaac accttaatta tccctttgat acatctacta acactagaca aaacgttgat
     6601 gcacaagaaa aaacatatac tactaatcct gtaaatatta acagagatca ggaagaaact
     6661 aaagaaacag agattcaata taaggatata tctggaagtc aaagcgacga aagtacacaa
     6721 ggtgaagaag caaaaaaaga agacgttcca gctaatctaa atgacaatga tagtgatata
     6781 gaagaaaaga gtgaagaaac ggaacctaaa aaggggtttt ggagtcgttt gtttggtagc
     6841 taaaataatt gattaggcac taaaagttat aaaattttag tgtcttttat atagtgagaa
     6901 cttctggtaa tcatcgatta tgtaaactaa agtatttcaa ataattaact gtattaatac
     6961 tctcatcatg attgcgttat aaacgttcgt tattgagaca aaatttaata gtactactac
     7021 acaaaaagag agtgcgaatt cgcactctct ttttgtgata aatgaatggt taagaaaata
     7081 attcatccac agttgtatca aacaatcttg ccaacttaaa tgctaatgtc aatgtaggat
     7141 catatttatt gttttctatt gcattaatag tttgcctaga cacttttaat tctttactta
     7201 aagtttcttg agaaattcct ttttgttttc tatattctct aattctattt ttcattaatt
     7261 taacctttag atgtatattt tttatttgta gtatagtaat taaacagcat aagaaatagt
     7321 gctacaatta taaagaaaat ttctggatat tgagaaaacc aagatccttc aatacttggt
     7381 gacaaacctg taaatttaag cactagtgta aataacatac aatatacaat ccaaataaaa
     7441 cttttagcca gtatttcaat aaacatttta cgttgtcttt catcgtatcg atcttgttgt
     7501 ccttttttat ctaatgtttc tgaaggtaaa tatttgttag ttatagccgt ccataaacaa
     7561 gaaaaaatta aaataataat aaaaggaatt aaattcatta taacacctca taaatgtaaa
     7621 aagtatttga catttatgag tgtaaatatt tttgatacaa atgtcaaata ctttttacat
     7681 tataatatat tttaaaacac cttattagta aaacaattac tatatagaaa gctgcgaact
     7741 cgtactcttt tttcttgtat aattattaaa atctcaattc aataatatgt tatggaattt
     7801 gagacactgt gagagacgct catttgcatt gacaatcaat ttatcaagat aatcccttat
     7861 catgtttaat tctataaact gtttgtcttg tgatattaac ttctttcgca atcttactaa
     7921 tcgctttgcc ttcttctaac atttccacca cgcgatgata aataacacgt ttctgtgggt
     7981 ctttagcatt tggtgaataa agtaaagggc gccctttata tacgcctttt tccttcgcaa
     8041 cttgaatccc ttgcgcttgt cgacgtttac tttcatttct ctcttgttct gaaaccattg
     8101 ctaatatttg aatgattaaa tctttcataa acttatccag taatggattg ccaattactt
     8161 cattcatcat aggtaagctg gtaatcatta actgaacgtc tttttctttt aaataattca
     8221 cagtttcaat aatttcatca tagttacgtc ctaaacgatc aatagattcc acaacgaatc
     8281 gatctcccat tctgacaaaa ttgagtgctt cttgaaatac aggtctattt tccactgact
     8341 ttcccgactg tttctctgta aagattttct ccacaccaaa cgtctttaaa ttatccaatt
     8401 gtctttctaa attttgatct atcgatgata ctctcgcata acctataatc attcatcttc
     8461 actccataat aaatatacac cctaatcata cgttttaatt gttataattt caacaattct
     8521 ttttgtatgg ttagggtgta ctcaaagtgt acatatctat aattaaaact tactaaaaat
     8581 aaatatagat tttttctttg taacagaacc gttcatttga aggtcatctc tatcataaat
     8641 atttaaatta actaaaaatt ttaatcatct gtttaatact tatgaaatgt atttacggta
     8701 ggtattaaaa ttgatgaaat ttatataagt gctttcaatg aaaatgaccg tttatttatc
     8761 ctcctgattt aaggagttag aaatttcgaa aacgattctt tccatttgtt gcatttgttc
     8821 catgtccaga tatttaatac attatagaaa accaaagacc atcactaatt aaacgcagtt
     8881 ttaaaatttc atcaggattg ccttcgtctt taaaatgggc ctcttttaat ataagttcta
     8941 ctctttcata cctaactctt tcaatgccat cgtttcatac gccgattctc ctgattccat
     9001 agcaaactca gcgataaaca ttgggaatac tgcattgagt tctattatat gctctttcat
     9061 tcgtggccat atttcacctc cagctttacc gtatgctgtt ataagttgct ctaatccttc
     9121 gtcgtcgaat acacgatggt gtcctataaa gtccattgat gggtcggagt gggttgcttc
     9181 agtccagtct atgagacctg tgacgtttgc ttggttatct accattatat gtcctggatg
     9241 taagtcccca tgtatcatgg tcgcatgtcg aggccatagt tcgtcgtttt ctaaccattg
     9301 tttccatctg ttccataatt catctgatac gccataagtt tctttaactt tattcattct
     9361 tctttgaaag tcatttttta tttcttgtat ggttttgata tttatatgct gaacgttaat
     9421 gttttcttct ggtatgttgt gtaaatctac gagtgtttca gctaatgtgt taataaagtt
     9481 ttctggtaat ggtttgtgtt caatttccca tacataattt tgtatttctg gatctattgt
     9541 ggctgcgggt ttacctgtaa gttttgggta agcaataagg tcttttgcat gtactttcca
     9601 cttcggtatt tcaaatgaaa cattcttctg taagaagtct accgtttgtt tttcgggttt
     9661 tgttcgttta taaacgtcag gtcttcttgg tagtctcaaa acccattcta ctccatgttt
     9721 atcttttcca aatgcaactt gaaaatcaag tcccgattca ttcaatgaga ttgtttgagg
     9781 ttggatgtgt aattgatatt tttctgcaca tttaataatt tcattatgtc gagtcatttt
     9841 attggatcct tatttctatt atatttttct tgtgaacgta ttttttatat tgatataaat
     9901 gaacctaata ttcaatataa attagtgtat agtttttaag ttatatcatg aagagattgt
     9961 cctgttaatt cccatttttt atctgataca tgtttaacaa accttgtatc atgtgatgta
    10021 aacaaaatga ttccaggata tttattcata aacatttcta atgcttctaa tgttttaata
    10081 tctaaaaaat tagttggttc atccaaaatt aacatattcg ctttcgttga aaataatact
    10141 gctaacgata atttcgttct ttccccacca ctcaaaacat tacaagaacg atcaagtgct
    10201 tcatttaaac ccaagttatt taaaatagct ctactgaatg attctgatga atccgtttca
    10261 tccattaaat attgcaataa tgaaacgtca cgcatgtctt cataagcaag ttgacgatag
    10321 tatgccattt gcactttagg agaacaatca attccctcta tttggtggta aatagcttca
    10381 agtaaagttg tcttacctac accatttgca cctacgagcg ctatattttt gccatatggt
    10441 atttggaatc gtacttgtgt tagcagtttt tgacttcctt taaccaatgt tagattttgt
    10501 gcaatgattg gataattatt atggatatca taaattttat tttgtgggaa attgaattca
    10561 tgataacttt gtggtttttc aacttcttcc aaatgttcca ttcttttttc aatatgctta
    10621 gcttgttttt gagcagcctt ctcaaccgtg cctttttgtt ttgatgcact taaacgatct
    10681 ggtgctatac ttttgttttt ttgttttgat gatgcttgtg ccatttgttg cgcttgattt
    10741 cgtttagctt tactggcttg ggacaatctt tgtttttcac ttatatactg ttcatattga
    10801 cgttgttgtt ctaactgttc ttgttcatat tgattttgat actgtgtgta attaccttta
    10861 aacactctta ttgtgccatc ttcttgtata tcccaaattg tgtcagcaat ttggtctata
    10921 agtgctctat catgacttac tataattaaa gtaccatagt aatattttaa aatatttttc
    10981 agataatctt taccaatttt atccaagtga tttgtaggtt catctaaaag taatatcgga
    11041 ctataatttg atatgacatt agctaattta tattttgctt tttcaccacc actcatactg
    11101 tcggttgtat gcataggtat atggagttca ctcattaaac taccgtctaa cgtgttaaaa
    11161 tcattttcca catccatgtt aagctgttca aaatattgaa tttcgccaac cgtttcaact
    11221 gttccagatt ctggttttgt tttttgagca atcatattta gtaatgtggt tttgccagta
    11281 ccattacccc caataagtgc tattttttca aattggtaag cgtaaagatg accgatgtta
    11341 agtgatcgta aatctgtcaa tttatgattg atttggttaa atttaattgt atattgttcc
    11401 atatttatac actccttgta tatttaaagg acgtgtacgc aaaaaaatga gacaggctac
    11461 tcccgtctca ttcacattac actttcaaac acttaaaaat ttattatgat gttttagtat
    11521 ttgaaagcgt ttattattcc tatcgaagga taaaaaatga cataagtcat cctatgagtg
    11581 tgtattgcgg acaagccttt ttgaattaat ttagttttgt attcaaaaag gtttatttga
    11641 gtctcataga agctgtcatt ttaatcctcc ttcatcgata aaatagtaat gttaatataa
    11701 cattttgttg gtttttttac aatatatctc taagtagaaa gattatataa caaaagtata
    11761 aaaatacaat tttagattga ttatacatct ccttaattta gagtgtactc ataaaatacg
    11821 gttctgttgc aaagttgaat ttataatata attttaacaa aaaggagtct tctgtatact
    11881 atgaactatt tcagatataa acaatttaac aaggatgtta tcactgtagc cgttggctac
    11941 tatctaagat atgcattgag ctatcgtgat atatctgaaa tattaagaga acgtggtgta
    12001 aacgttcatc attcaacgat ctaccgttgg gttcaagaat atgccccaat tttatatcaa
    12061 atttggaaga aaaagcataa aaaagcttat tacaaatggc gtattgatga gacgtatatc
    12121 aaaataaaag gaaaatggag ctatttatat cgtgccattg atacagaggg acatacatta
    12181 gatatttggt tgcgtaagca acgagataat cattcagcat atgcgtttat caaacgtctc
    12241 attaaacaat ttggtaagcc tcaaaaggta gttacagatc aggcaccttc aacgaaggca
    12301 gcaatggcta aaataattaa agcttttaaa cttaaacctg actgtcattg tacatcgaaa
    12361 tatctgaata acctcattga gcaagatcac cgtcatatta aagtaagaaa gacaagatat
    12421 caaagtatca atacggcaaa gaatacttta aaaggtattg aatgtattta cgctctatat
    12481 aaaaagaacc gtaggtctct tcagatctac ggattttccc catgccacga aattagcatc
    12541 atgctagcaa gttaaacgaa cactgacatg atatattagt gattagctat attttttact
    12601 ttgcaacaga accagccatt taatatgact gttacaatta ctaagattca agcactatta
    12661 cgccgcacgt atgatttcac cactcaagtt aataatttaa cagtagatga ttgcgagtta
    12721 ctacttgatg cagcaaagct taaatttaat gaagaaacca tagacctgac acacactgaa
    12781 ttgcaaatca tgcatagctt attccagaac aagggcaaat tcgtcagtcg taatgcgtta
    12841 atcgaaaaat gctgggaatc agaacacttc attgatgaca atacgcttgc tgtcaacatt
    12901 acacgtttac gcaaaaagct acaaaaacta ggacttacag attttatcga aacgaagaaa
    12961 aatgtcggat atcgtgtagg tgacgtatga atttcttgaa atcaatccaa cgtgaaattt
    13021 atattgtcat ccttacttgt gctttattct actttatatt attcatgtat aatgtgccga
    13081 tgcaagcata tatgattggt ctaggtattg tattgtttgt ttcaatgatt tactggggta
    13141 tccattacat gaactttaaa aaagaataaa cactacagga acagaacgaa gatttaagaa
    13201 tcgaaaacca taaacttcgt aatgacttta ttaactacca aagtgagtta gagtcatatt
    13261 ttttaatgtg ggtgcatcaa atcaagacac cgattacagc atcaaagtta ctgcttgaag
    13321 atcctgatga acacgtgatt tctaacgtgc gtaatgaagt cttacaaatt gataattaca
    13381 cgaatcttgc actgaactat ttgaaactca tgaaccaaaa gacatacatg gtctttatgg
    13441 aagtgagtgt agatgaatta attcgaccac tgattaaacg ttatgcgata cagtttattc
    13501 atcatcaaac aaagttgcat tatgagaaaa gtgaagcggt tatattaaca gatgccaaat
    13561 gggcatcaat tatgattgag caaatattaa acaatgcatt aaaatatgca cgtggcaaag
    13621 atgtgtggat tacgtttgac gaaaatacaa agaaattatc aatccgagat aacggtatcg
    13681 gcattaatgc gagtgattta ccgaaaatct ttgataaagg tttctcgggc tataacggta
    13741 gaataagtga gaaatcaagc ggtattggtt tatatattgt cagcacaatc tcaaagcgct
    13801 taggccataa agtaagtgct acatctacat taaacgatgg ttcaatattc accattcaat
    13861 ttaaataact ccaatctttc atttttgtaa gattagcggc tgtttttgta agaatagata
    13921 aaggcagcct tttctaatcg cgcgtaagat aaaggtaaca acaaactaag aaaggtgcca
    13981 gaggtgaaaa atttgaataa tataattgaa ataaataact taacaaagca atatggaagt
    14041 cagatagcag ttaataattt gagtataact gttgaaagtg gacaaattta tggtttttta
    14101 ggaagaaatg gtgcaggcaa aacaactact ataagaatgc ttttaggctt aattaaacct
    14161 acgaaaggta atattaaaat atttgaaaaa gagttcgaaa gtaataaaac tgaaatttta
    14221 aaaaatattg gtgctatggt tgaaacgcca ggtttttata gtaatttgac agctaaagag
    14281 aacttaacta taaatgctaa aatattaggt atacaaaaag aaaatgcaat tgaagaagtg
    14341 ttagaaatag taggactagc ttctgaaaaa gtaaaattgt ttaaaaatta ttctttaggt
    14401 atgaagcaac gtttagggat tgcgagagct ttattgcaca atcccgaatt attgatactt
    14461 gatgagccga cgaatggatt agatcctatt ggcataaaag aaattagaaa gttgattaag
    14521 gatctggctc aatctagaaa tataaccatt ttaatttcaa gtcatatatt gtcagaaata
    14581 gagcagttag tagacaaggt gggtattatt cataacggag ttttgttaga agaaattatg
    14641 tatgaagatt taaaaaaaaa gaacagacaa tttataagta tatcagtatc agatgaagaa
    14701 aaagttgcat gtttgttgga aactaacttc ggaatttatg actataaaat taaagaaaat
    14761 ggcgaattta aaatttattc acatattgat agacaacaag aaattaatag attattagta
    14821 ttaaacaata ttgatgtttt ccagatgaga gtgatagaag ataatctaga aacttatttc
    14881 gaagacttag taggaggtgg cacaattgga taatctactc cgtacagaat ttattaagtt
    14941 aaaaagatca tatatgtttc taataagtat tttaggtaca tgcgtagcac cttttatggt
    15001 ggttgtagct tcttttatta gtatgcggac gaaagtaccg actcctaata ttgtatttaa
    15061 acagttattt gaagaagtca gtttatatca tatgctaatt attggacctc ctctatatgg
    15121 ggttataata gcctatttgt ttggaagaga atatatagaa gatactttaa aaaacttatt
    15181 aattatacct atatctagag aaagtttttt agtaagtaaa ataatattat tattcttgtg
    15241 gattcaaaca ctatctgtta ttgcatggtt gctaacttta atgctaggta tgctattgca
    15301 ttttcaaggg ttaagccaga gtttaataat tgattcattc tttacatttg ttattggcgg
    15361 agtgttatta tggatattat ctccaccaat aattattttg tcgatatatt ttaaaaatta
    15421 tgttcccaca attgttttaa ccataataat tactttgata aatttaatga ctgctaattc
    15481 tgaacataga ggattatttc cttgggctgc agttggagac atatctagag gaacattacc
    15541 taatacttat ccatttctat tatctttaat tatcataatt gttacatcta tattcagtgt
    15601 aattatatta ttctcatact ttaaaaaaac tgatataagt taaaaggagg agaaaaatgg
    15661 gttttataga gcagattaaa gcatttattt taggtgtagt tgaagggttg acagaatttg
    15721 ctccagtatc atcaacaggt catatgatta ttgttgatga tatgtggtta aacactgctg
    15781 acgatttagg aagtgcgtct gcaactactt ttaaggtggt aatacagtta ggaggttctg
    15841 ttgcaaagtt gaatttataa tataatttta acaaaaagga gtcttctgta tgaactattt
    15901 cagatataaa caatttaaca aggatgttat cactgtagcc gttggctact atctaagata
    15961 tgcattgagc tatcgtgata tatctgaaat attaagagaa cgtggtgtaa acgttcatca
    16021 ttcaacggtc taccgttggg ttcaagaata tgccccaatt ttatatcaaa tttggaagaa
    16081 aaagcataaa aaagcttatt acaaatggcg tattgatgag acgtacatca aaataaaagg
    16141 aaaatggagc tatttatatc gtgccattga tgcagaggga catacattag atatttggtt
    16201 gcgtaagcaa cgagataatc attcagcata tgcgtttatc aaacgtctca ttaaacaatt
    16261 tggtaaacct caaaaggtaa ttacagatca ggcaccttca acgaaggtag caatggttaa
    16321 agtaattaaa gcttttaaac ttaaacctga ctgccattgt acatcgaaat atctgaataa
    16381 cctcattgag caagatcacc gtcatattaa agtaagaaag acaaggtatc aaagtatcaa
    16441 tacagcaaag aatactttaa aaggtattga gtgtatttac gctctatata aaaagaaccg
    16501 caggtctctt cagatctacg gattttcgcc atgccacgaa attagcatca tgctagcaag
    16561 ttaagcgaac actgacatga taaattagtg gttagctata tttttttact ttgcaacaga
    16621 accatcattt ttattaaaat actcttttgt aaaatctttc tgctcttcaa tgtatttaat
    16681 ttctttacct ctaaatctat tatagctatt tgatgattac aataaaattg atcttacctt
    16741 attgcccttg gaagagttag ataattaggt tctgttgcaa agtaaaaaaa tatagctaac
    16801 cactaattta tcatgtcagt gttcgcttaa cttgctagca tgatgctaat ttcgtggcat
    16861 ggcgaaaatc cgtagatctg aagagacctg cggttctttt tatatagagc gtaaatacac
    16921 tcaatacctt ttaaagtatt ctttgctgta ttgatacttt gataccttgt ctttcttact
    16981 ttaatatgac ggtgatcttg ctcaatgagg ttattcagat atttcgatgt acaatggcag
    17041 tcaggtttaa gtttaaaagc tttaattact ttaaccattg ctaccttcgt tgaaggtgcc
    17101 tgatctgtaa ttaccttttg aggtttacca aattgtttaa tgagacgttt gataaacgca
    17161 tatgctgaat gattatctcg ttgcttacgc aaccaaatat ctaatgtatg tccctctgta
    17221 tcaatggcac gatataaata gctccatttt ccttttattt tgatatacgt ctcatcaata
    17281 cgccatttgt aataagcttt tttatgcttt ttcttccaaa tttgatataa aattggggca
    17341 tattcttgaa cccaacggta gatcgttgaa tgatgaacgt ttacaccacg ttctcttaat
    17401 atttcagata tatcacgata gctcaatgca tatcttagat agtagccaac ggctacagtg
    17461 ataacatcct tgttaaattg tttatatctg aaatagttca tacagaagac tcctttttgt
    17521 taaaattata ttataaattc aactttgcaa cagaacctca tttactatat gggcatctct
    17581 ttcattatta atacaaagct ttgtatctcc gatattaggc aaaggtgtaa acgaattagg
    17641 tgatactata ggattcaaca ttatattaat cgtttcttta ataatgatta tcttcttatt
    17701 ttttataaat cgtagtaaaa atatctccta tgattatata aaagttcaaa gaggtgaagc
    17761 caatgaataa attagaaaaa tggtctttgg tatttattat ttttacattt ctctcttcat
    17821 tagcactttt atatttcaaa tataatttta gttcggttat gccagtccta agtctttcta
    17881 ttttaactat actaatattg ttgacgagta ttattactgt agtttcagtt aatgatgaag
    17941 atacttaaaa cgttcattag tgaaacaggt attatattaa aaaagcgtac gaatttgtac
    18001 gcttttttct tgtgttatta ttaaaatctc ataacaggaa aatattatga gattttagac
    18061 gctgtcagaa cgtctctttt acatcgagtg acattgaatc aaagtctttg tatgttaatg
    18121 atatataaaa ttatttagta gattcattat agtaagctag attagttgct ctacttgttt
    18181 ttattctctt ttgcctctaa tttattgaga taacgataaa tagttgtacg tgaaacttgc
    18241 cactgctctg caattgtttt aattggcgta ccattatcat aaagtgtctt aagtaagttt
    18301 aaatcttgtt tatttaattt ttcaggtcta cctccatatc ggcctctagc acgtgctgca
    18361 attcgaccgg ctgatgatcg ctctaaaatt aaattacgtt caaactctgc aaatgctgcg
    18421 aataaatgaa ataataattg tcctgtagaa cttgatttat ccatcgttat attttcttct
    18481 aaactatgaa aactcacacc tcgttcgtta agttcattaa ctaacgtgat taaatcctcc
    18541 atgttccgtc ctagtctatc taatctccaa acaacaatcg tatctcctga cctcgcaaat
    18601 tcaattgctt tatctaaacc aggtcgctta ctttttgaac cactcatatg gtcattaaat
    18661 atcttttcac aaccatatgt atttaatcga tcctcctgta aattcaaatt ttgtaatcca
    18721 gttgaaactc ttgcataacc tattttcaaa atacagacct cctatataca cctttagtgt
    18781 accataactt gattacgagg tcttttgtga acatagattt tttgttgggt ttttgaacac
    18841 ataattctat gtaatactta cttatttaga caaaaaacaa gagtgtacag aaaatggtta
    18901 ttttctggac actctcatct ttaataatat attttaaatg tcattaacaa aactaattta
    18961 ataagagtca agtatggttt acatatgtat tatgtttgaa acatacctct aattactttt
    19021 tactaatatc atttaaaatg tctcgcaatt cttcaatttc tttgttattt aattcttcat
    19081 ttttcgcaaa attcagcact aaacttttca tatcccctcc atacagttta ttaagaaagg
    19141 ttttagcagt tttcatttta atatcgtctt ctttaatatt tgatgagtaa aaataaatat
    19201 tttctgattt gtatcgtttt ataatctctt ttttatatag tcttgtgatt aatgttctaa
    19261 tcgttttatc actaacttct ttatattttt gaatttcaac tacaatttca ttagctgata
    19321 ctgatttttt atcccatatt atattcataa catcccattc agccatagat atttcaactt
    19381 gcttattggt catttaaaac acccattcct tttaatattt tttcacttat taattcagca
    19441 tttttcccag acgggtttcc atctgataaa tgtgtagcaa aataatactt atcatgattt
    19501 gtaattacgt aacctacaaa ccacccatta ttatacttcc cgtttactat acctgtacct
    19561 gttttcccat acagttcata cttttcattt ttcttaatca ataatgaaga agataattga
    19621 ttctttgctt ttttactaaa atggttattt tgttccatca tatttttaaa aactattact
    19681 tgttcaagat tagatatttt caaactatct tccatccaat agcttttata acttcccaaa
    19741 ttttcattac cataatttaa ttgcttgagt tgagccgcag tatagttctt tggtatttga
    19801 ttactaatac gttcgaagta ccaattaact gaattttgca ttgctgtatt taaatcttgt
    19861 tccttattcc aagactcgaa aagataatgt ttatgattcc atgacatacg tgaattttta
    19921 tcacttataa tatgacggtc aagtccaaac agtgctaaat aaattttgta agttgaatca
    19981 ggagaatatc tttttctact ttctttttca ttataaatat agtatttgtc tttcttcatg
    20041 ctgtacataa cgaaagatcc actatttgaa ccaaaatttt tactttcatc taaaatttgg
    20101 taatcgcttt gtaagggctt tttataatta taatcagtta aggattgccc cattaaaaac
    20161 tggctttgaa ttatcatgat aaaaaaagta aaaatacaaa taaaaattag aattaatttt
    20221 gactgctttt tcagatcggc ttcttttata ttaattaatc tacttttgag taatgatttt
    20281 ttaccattaa atgaatggct taatatattt ttgttggaaa atggggtttt taatacggag
    20341 tccataatag attccgcata agttttaaat tcatttttgt taatattatt aaggacaaat
    20401 ctatcggctt ctacttcatt gtcatgaatt atctttcttt ttacaatatg tactaatgga
    20461 ttgtaactca taataataga gaagatatta aagataatta aatgtaaagt atctctattt
    20521 ttagcatgag catattcatg cagtattata tattttagtc ttttatcaat tacactttta
    20581 aaatatgaac taggaatcaa aataatatat ttcccatacc aaaaagttat tggagattga
    20641 atagcctctg cttttcgaat cacaatattt tttttatatt gatggttgaa aagtatcgta
    20701 tctattttat ttttttcatt ttcgtttaga taaagtgact gtttctttaa atatttaaga
    20761 tataataagg ctttcaaaaa tttaaaactt aaaataataa ctaaaactat ccaaataact
    20821 gtgcagatat tatcaattga atcccaatta aacttatgga tatctgttgt gaactcttga
    20881 ataggtttgg tggtatttat gttatggttc aaatcgtgtg acttactttc aactgtgggc
    20941 gcttgattat tcacattatt aaattttata aaagagaatt taattgggat aaaaggaatt
    21001 aatccagcaa gcatagttag ataccaaact ttataattta aactataatt aaaatagcgt
    21061 tttaatatgt acctaaaaaa tactaacaat agaaatataa aacaaaagct tactacgctc
    21121 attattagta atttagccat tttgaaacct tctttcaaat atttataata aacaattgac
    21181 atcaatatta caattgtaat attattgatt tataaaaatt acaactgtaa tatcggaggg
    21241 tttattttga aaaagttaat atttttaatt gtaattgctt tagttttaag tgcatgtaat
    21301 tcaaacagtt cacatgccaa agagttaaat gatttagaaa aaaaatataa tgctcatatt
    21361 ggtgtttatg ctttaaatac taaaagtggt aaggaagtaa aatttaattc agataagaga
    21421 tttgcctatg cttcgacttc aaaagcgata aatagtgcta ttttgttaga acaagtacct
    21481 tataataagt taaataaaaa agtacatatt aacaaagatg atatagttgc ttattctcct
    21541 attttagaaa aatatgtagg aaaagatatc actttaaaag aacttattga ggcttcaatg
    21601 acatatagtg ataatacagc aaacaataaa attataaaag aaatcggtgg aatcaaaaaa
    21661 gttaaacaac gtctaaaaga actaggagat aaagtaacaa atccagttag atatgagata
    21721 gaattaaatt actattcacc aaagagcaaa aaagatactt caacgcctgc tgctttcggc
    21781 aagactttaa ataaacttat cgcaaatgga aaattaagca aaaaaaataa aaatttctta
    21841 cttgatttaa tgtttaataa taaaaacgga gacactttaa ttaaagatgg tgttccaaaa
    21901 gactataagg ttgctgataa aagtggtcaa gcaataacat atgcttctag aaatgatgtt
    21961 gcttttgttt atcctaaggg ccaatctgaa cctattgttt tagtcatttt tacgaataaa
    22021 gacaataaaa gtgataagcc aaatgataag ttgataagtg aaaccgccaa gagtgtaatg
    22081 aaggaatttt aatattctaa atgcataata aatactgata acatcttata gtttgtatta
    22141 tattttgtat tatcgttgac atgtataatt ttgatatcaa aaactgattt tccctttatt
    22201 attttcgaga tttattttct taattctctt taacaaacta gaaatattgt atatacaaaa
    22261 aatcataaat aatagatgaa tagtttaatt ataggtgttc atcaatcgaa aaagcaacgt
    22321 atcttattta aagtgcgttg cttttttctc atttataagg ttaaataatt ctcatatatc
    22381 aagcaaagtg acaatagcat tttacaagta ttttttattg ttcgattagg gtaaacctaa
    22441 ataatacata aattatatta caatatgttt attatagagg ctaaagtatc ttagaaattt
    22501 ggatagtagg tttttcggga ataaaagtat agttggcttt aatatataat taagctaagc
    22561 tatcatttat atttactcga ttataattcg cacttcaact tttttataac gtaaaaatta
    22621 aaacgtagtt ttatttatct ttagtaatat ctttttaaac actacagttt cttcattagt
    22681 taaattagcg aagtaatgat tattaagttg ataggctttc ttttctaatg ttggccataa
    22741 gtcttttgct ttatttgtac tgtttattag cacagttctt ctattttcat tatcagtttg
    22801 acgtgttatt agatcctttt tggacatctt atctaatatt ccagatattg ttgaaggttc
    22861 taaatttaaa gtattaccaa tcgctttagg tgtattcaaa ttactattaa tcaagcaatt
    22921 caaaacacca tattctgctg gagtaatatt atagggactt aataaacttt taaaatgttt
    22981 aaaaactcta ttctgagaag tactcaacaa ataatttata caattatcta attccacaac
    23041 taaaacctct cttaaatcat tagtattgac tcgcttatca tatcatgata agttttgtag
    23101 gaaaatagtt ttgcaacaaa aacatacttc tacaaaacaa ttgtgaaaga aggctaataa
    23161 atgttcaatg cggtagtagt gagaaaaagt gcatcaaatg ttagttataa agtagaaaaa
    23221 gttgatgaat ctcatttatc gaagggtgat gtattagtaa aagtggtata ctcttcaata
    23281 aattataagg atatgctagc tttacaatat aaaggcggtg taattagaga ttatcctatg
    23341 attcctggta tagattttgc aggtattgtt gaatcaagtt cgaatgataa gtttaaagaa
    23401 ggcgataatg tattagttac tggttatgat gttggcgtga cacatacagg tggattttca
    23461 gaatatgcac aagtgcctgg agagtggatt gttcctattc cccaagaaat gtctattaaa
    23521 gagtctatgg tatatggcac agccggtttt acggcagcat tatcaatttt tgaactagaa
    23581 aaatatggaa tgaatatcaa atcacaacct gaaattttag tgtctggggc tacaggtggt
    23641 gtgggcagtg ttgctataca aattttacat aaaattggat atgaaaatat cactgctatc
    23701 gtaagaaaag aaaagcaaat agaaatcgca aaaaaattag gtgcaaaaca agtaataata
    23761 attgaagatg ataataaacc gcttaaaaaa ggtatttttg attatttctt agatacagtg
    23821 gggagtaatg taacattata cggtttaaaa cgtctaaatt atcaaggtgt tgctactgta
    23881 tgtggaaatg tagcaggaaa ttcacttaac gctaatatat taccgtttat tcttagaggt
    23941 attaaattaa ttggcattga ttctgtatat gttgatcata atatccgtga agatatatgg
    24001 agtaagttag caaatgaatg gaatatagga aattcacttc tatacaatga aattggattt
    24061 gaagaattct ataaaacgat agatcagctt ttaaaaggac aacatttagg aagaactatt
    24121 ttaaaagtat
//
