LOCUS       CP051940               20650 bp    DNA     circular BCT 24-SEP-2020
DEFINITION  Staphylococcus aureus strain ER10234.3 plasmid pER10234.3A.1,
            complete sequence.
ACCESSION   CP051940
VERSION     CP051940.1
DBLINK      BioProject: PRJNA470993
            BioSample: SAMN14669423
KEYWORDS    .
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 20650)
  AUTHORS   Caban,A.B., Pak,T., Kumaresh,A., Dupper,A., Chacko,K.,
            Sullivan,M.J., Altman,D.R. and van Bakel,H.
  TITLE     PathoSPOT genomic surveillance reveals prolonged under the radar
            outbreaks of nosocomial methicillin resistant S. aureus bloodstream
            infections
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 20650)
  AUTHORS   Caban,A.B., Pak,T., Kumaresh,A., Dupper,A., Chacko,K.,
            Sullivan,M.J., Altman,D.R. and van Bakel,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2020) Genetics and Genomic Sciences, Icahn School
            of Medicine, One Gustave L. Levy Place Box 1498, New York, NY 10029,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 233.335052631579x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/23/2020 10:24:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 2,924
            CDSs (total)                      :: 2,844
            Genes (coding)                    :: 2,638
            CDSs (with protein)               :: 2,638
            Genes (RNA)                       :: 80
            rRNAs                             :: 6, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 206
            CDSs (without protein)            :: 206
            Pseudo Genes (ambiguous residues) :: 0 of 206
            Pseudo Genes (frameshifted)       :: 176 of 206
            Pseudo Genes (incomplete)         :: 28 of 206
            Pseudo Genes (internal stop)      :: 15 of 206
            Pseudo Genes (multiple problems)  :: 13 of 206
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..20650
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="ER10234.3"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pER10234.3A.1"
                     /geo_loc_name="USA:New York City"
                     /lat_lon="40.7903114 N 73.9528738 W"
                     /collection_date="2017"
                     /collected_by="Mount Sinai Hospital"
     gene            join(20650,1..1757)
                     /gene="blaR1"
                     /locus_tag="HIK83_14505"
     ARG             4..1754
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="95.55"
                     /coverage="99.83"
     gene            1747..2126
                     /gene="blaI"
                     /locus_tag="HIK83_14510"
                     /pseudo=""
     CDS             1747..2126
                     /gene="blaI"
                     /locus_tag="HIK83_14510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001284656.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="penicillinase repressor BlaI"
                     /name="blaI"
     gene            2390..2983
                     /locus_tag="HIK83_14515"
     CDS             2390..2983
                     /locus_tag="HIK83_14515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="QOA98548.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNQKDLNLLKTLYDNGTPI
                     KTIAEQWHVSRTTIYRYLNKLEDKEDEKQGEVSN"
                     /name="recombinase family protein"
     gene            2955..4397
                     /locus_tag="HIK83_14520"
     CDS             2955..4397
                     /locus_tag="HIK83_14520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000790716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DDE-type integrase/transposase/recombinase"
                     /protein_id="QOA98549.1"
                     /translation="MKNKEKYLTNFSEAKRKKATQKYNIIKPFILGEQSLSSISKSKGI
                     ALSTLYRWNKSYKEQGLKGLIYATRADKGTRKIEPKIIDEIERLALMNKRNSIATIHRK
                     ITNYCKENNFDIPSYKQIYSVIKAMPKSVIDFSHQGEKYYQNKYDLIQIRESSRPNEIW
                     QADHTLLDIFILDQKGNINRPWLTIIMDDYSRAIAGYFLSFDAPNAQNTALTLHQAIWN
                     KNDTNWPVCGIPEKFYTDHGSDFTSHHMEQVAIDLKINLMFSKVGVPRGRGKIERFFQT
                     VNQTFLEQLPGYINNNDTPSNLINFHNFEEKLRYFLIEDYNQKEHSTIHTTPISHWNSN
                     HFFPNMPSSLEQLDLLLLEIPKSRKVHSDGIHFQGFRYSNTNLEAYVGEYVLIRYNPND
                     MAEIRMFYRDEFLCTAICPEIADYSIDIKDIQHARSQRRKHLKQNIASPSTTELIKEEK
                     NCGYSPQETTKNVKKLKRYRND"
                     /name="DDE-type integrase/transposase/recombinase"
     gene            4390..5205
                     /locus_tag="HIK83_14525"
     CDS             4390..5205
                     /locus_tag="HIK83_14525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019467708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="QOA98550.1"
                     /translation="MTKNQNFIETKEYKRFAEFCDACIKYQYIGICYGQPGVGKTLSSR
                     YYTNWDTIEKQVNHRGWEDLASKTTDDILSVDKIFYNAPAEKQTKLRNDLYSITAIIDL
                     GQKLHVVNKYGHEHSKHYSDMFKYIDLIIVDEIDRLKVQHLEQLRAIYDEHNLAMIFIG
                     MPGIEKKLSRYPQLYSRIGFAHEFDNLSKDETHHILECKWQDLGFDLKLEDFTDYEAIT
                     TIIKITKGNFRLIHRLFAQIDRIMDINGLDKISTEVVETARDSLVIGIR"
                     /name="AAA family ATPase"
     gene            complement(5325..6299)
                     /locus_tag="HIK83_14530"
     CDS             complement(5325..6299)
                     /locus_tag="HIK83_14530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4062 domain-containing protein"
                     /protein_id="QOA98551.1"
                     /translation="MSNTKIKYQIFISSTYLDLIEERQAVVEAVLNSNNIPAGMELFNS
                     SSKSQWEIITQWINESDAVILLLGSSYGTIDSEENISYTEMEYNFAKSLGKPIYVFEMN
                     KASTESAEKSKKLDEFKTKVKENRLISPNINDISELKSKVSQTLMQSVPSEIKENSGWI
                     RVQDCGKNVKKLKKLDAIQRDLDTYDFLKEELYKIFMYVKTFYFQHTPFDDSYIEDIEN
                     YLLNYENNPHKSFMKIKVYDYKNFLKHLKNILILIKQGKKPLAQAGHFKLSFYEEDLKL
                     LQKNYKATLVDIKGLNKHFYKECDRCLKAYNIFIEGINKHLYE"
                     /name="DUF4062 domain-containing protein"
     gene            complement(6511..6603)
                     /locus_tag="HIK83_14535"
     CDS             complement(6511..6603)
                     /locus_tag="HIK83_14535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="QOA98552.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(6772..7119)
                     /locus_tag="HIK83_14540"
     CDS             complement(6772..7119)
                     /locus_tag="HIK83_14540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="QOA98553.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNQEGF"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(7138..7755)
                     /gene="cadD"
                     /locus_tag="HIK83_14545"
     ARG             complement(7142..7755)
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="99.51"
                     /coverage="100.0"
     gene            complement(8965..9274)
                     /locus_tag="HIK83_14550"
                     /pseudo=""
     CDS             complement(8965..9274)
                     /locus_tag="HIK83_14550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002483623.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            complement(9258..9934)
                     /locus_tag="HIK83_14555"
                     /pseudo=""
     CDS             complement(9258..9934)
                     /locus_tag="HIK83_14555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            10345..11088
                     /locus_tag="HIK83_14560"
     CDS             10345..11088
                     /locus_tag="HIK83_14560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="QOA98555.1"
                     /translation="MKSVKRLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESATEDKQKKESDNINFESKSDAQIVEILKNQINTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNAR
                     QNVDAQEKTYTTSPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAQREDVSANPND
                     NDSDIEEKSEETEAKKGFWSRLFGN"
                     /name="DUF536 domain-containing protein"
     gene            complement(11307..11492)
                     /locus_tag="HIK83_14565"
     CDS             complement(11307..11492)
                     /locus_tag="HIK83_14565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000466619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOA98556.1"
                     /translation="MFGDQRQEATKYVIKEGYQDIYFLNKNGEWYYFEVRSVWRGKHII
                     RVKDGLLGWRKEIVTE"
                     /name="hypothetical protein"
     gene            11641..11712
                     /locus_tag="HIK83_14570"
     CDS             11641..11712
                     /locus_tag="HIK83_14570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="QOA98565.1"
                     /translation="MNEILVHIMTTAISGCLVTLFGY"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(11950..12291)
                     /locus_tag="HIK83_14575"
     CDS             complement(11950..12291)
                     /locus_tag="HIK83_14575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000761340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="QOA98557.1"
                     /translation="MKLAEAIKEQRELKGWSQEELANILKVSRQSVSKWESAKNYPSLD
                     ILIAMSDLFGISLEHLIKGDARFKKVILEGNYRESNRVPSIVDFLYDFWWLFFPVAGFL
                     VWAIHSFMG"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(12378..13238)
                     /locus_tag="HIK83_14580"
     CDS             complement(12378..13238)
                     /locus_tag="HIK83_14580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000145511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="QOA98558.1"
                     /translation="MTGETVVYKNEMNLVPLRRFTATEINLFFAMCNKLKEQDTNTLRL
                     SFDELKKLSNYSPETRNINRFANDLDNVYKKMLNLTIRYEDDDVIERFVLFNHYRIHKR
                     EQYLEISTSSNLKHILNSITNNFTKFELKEMTRLKSTYSKNMFRLLKQYKHTGYLKIHI
                     DDFKNRLDIPKSYRMTDINKNVFKPIIIELGSIFNNLTINKIKAKKGRKIEWIEFTFDA
                     EKRIHNKRQPQMSKIDKSRQYVRREKTPKWLEERSYEKQPQKDYDPQLEKEREDFLKQL
                     ELNWE"
                     /name="replication initiation protein"
     gene            13278..13586
                     /locus_tag="HIK83_14585"
     CDS             13278..13586
                     /locus_tag="HIK83_14585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001020849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOA98559.1"
                     /translation="MNIHSHLKTFIHNKLLYYQCQTIKGVQLFKTLLLCGKNTPFMWQK
                     HSFYVAKTLLLCGKNTPLGIEIPCCSRAEQAPKKVFKKIYKNILKSSRGLPIFHPKK"
                     /name="hypothetical protein"
     gene            complement(13621..14889)
                     /locus_tag="HIK83_14590"
                     /pseudo=""
     CDS             complement(13621..14889)
                     /locus_tag="HIK83_14590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331753.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid recombination protein"
                     /name="plasmid recombination protein"
     gene            complement(15127..15753)
                     /locus_tag="HIK83_14595"
     CDS             complement(15127..15753)
                     /locus_tag="HIK83_14595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000593102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="QOA98560.1"
                     /translation="MIKLENVFVKKGNKNILDGCNFNFEKGKSYALVGESGAGKSTLLN
                     IIAGFEDVSQGSIYIEDKLLKKKVDFYRYTLGYLFQNFALLENQTISQNLDLALKFKKN
                     KKDNMNLKKEVLKKVGLDLDIKRIVSSLSGGEQQRVALARLILKDPKIILADEPTGSLD
                     TKNGKIVIDLLLKLLDENKTMIVVTHDLELAKRFDVIVNISELRS"
                     /name="ABC transporter ATP-binding protein"
     gene            complement(15765..16076)
                     /locus_tag="HIK83_14600"
     CDS             complement(15765..16076)
                     /locus_tag="HIK83_14600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YxeA family protein"
                     /protein_id="QOA98561.1"
                     /translation="MKRTLIIVTIVLLIIILSLLLVRNEHLDRFNPLLKEKVSYAKVPK
                     DTQDYRNITVYSKNGEKKSYKLDFLGYDPTKEYVKVNHKGKYVRSIEYITKDIPSFLK"
                     /name="YxeA family protein"
     gene            complement(16080..18014)
                     /locus_tag="HIK83_14605"
     CDS             complement(16080..18014)
                     /locus_tag="HIK83_14605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001670421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="QOA98562.1"
                     /translation="MKKFKLFLDFSTLLLISGLLFLFFFKENEEIIPESSNILTISNWD
                     KSNSKSKVLDVIESGAKNQNIQIIKSVKDFDNKKEFFVFNSKRNNSDFIRNKTSLLTPS
                     DLLNREIKGKYYIIGEHFNVEELTSELKKAGLTSEVEYINRNILFFELVIDNDLLVPFI
                     FLGVLYLLYFLYDRGYNLKFYAIQKLHGFSTTRIIFHNIHIKIIYWLVLTAIFFIANIL
                     IIHIANLELDFLMFIRRFIVLLFVFACITTLLWLISYSLLLKLSIPLILKGKKGYKFSI
                     FMGTFTKCIMVLILSFLLAQNLNAYTKLKNIYDSEKIWQKLDNYYTLEISPNIRNSEEK
                     QILETNIYNLIKKSEQLGGLLLKNNNIANPDKNNYIPENGNVFFINNNFLNFYKNINHD
                     FKMIDNHSDKINVFIPPRLQYQKSEIQKNHQGWIDFQKQQNKKVDVQVLSKNVSVFSFD
                     RTTNLKFGYLDSPIVMLLTLDDLTGDFYLAAVSQGGYLFKDLDTLKQLLKDNHLEEEIS
                     GITNYKDSVLNELNETKTKMIITIVTIIINVFILLIATVFETIQYFSWNKKQLLLRKIH
                     GYSLFSSNVRYLTISILLSIMLAYTTHILFGSKILLFIIMSIAIIQHLLQIAYIKYLEK
                     YFKDLMREI"
                     /name="bacteriocin-associated integral membrane family
                     protein"
     gene            complement(18089..18382)
                     /locus_tag="HIK83_14610"
     CDS             complement(18089..18382)
                     /locus_tag="HIK83_14610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000726503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="QOA98563.1"
                     /translation="MKKKFVSSCIASTILFGTLLGVTYKAEAATVHVAGGVWSHGIGKH
                     YVWSYYSHNKRNHGSTAVGKYSSFSGVARPGVQSKASAPKAWGGNKTFYSLH"
                     /name="lactococcin 972 family bacteriocin"
     gene            complement(18796..19329)
                     /locus_tag="HIK83_14615"
     CDS             complement(18796..19329)
                     /locus_tag="HIK83_14615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001823239.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="QOA98566.1"
                     /translation="MIVGYARVSSNDQNLERQLENLKTFCAEKIFTEKQSGKSIENRPV
                     LQEALNFLRMGDRFVVESIDCLGRNYDEVVGNPLLDKFMKDLIIQILAMVSEQERNESK
                     RRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRIIYHRVVEMLEEGQSISKIAKEVNIT
                     RQTIYRIKNDNDLI"
                     /name="recombinase family protein"
     gene            complement(19698..20543)
                     /gene="blaZ"
                     /locus_tag="HIK83_14620"
     ARG             complement(19702..20543)
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(19699..20543)
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.8"
                     /coverage="100.0"
     BGC             13089..20650
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          complement(8761..8908)
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="81.333"
                     /coverage="100.0"
                     /evalue="2.96e-25"
     Typing          10346..11088
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(12379..13238)
                     /name="rep_cluster_2214"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(14615..14889)
                     /name="MOBV"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="94.565"
                     /coverage="100.0"
                     /evalue="4.71e-46"
ORIGIN
        1 tggctaaatt actaataatg agtgtagtaa gcttttgttt tatatttcta ttgttagtat
       61 tttttaggta catattaaaa cgctatttta attatagttt aaattataaa gtttggtatc
      121 taactgtgct tgctggatta attcctttta tcccaattaa attctctttt ataaaattta
      181 ataatgtgaa taatcaagcg cccacagttg aaagtaagtc acacgacttg aaccataaca
      241 taattaccac caaacctgtt caagagttcg caacagatat ccataagttt aattgggatt
      301 caattgataa tatctgcaca gttatttgga tagttttagt tattatttta agttttaaat
      361 ttttgaaagc cttattatat cttaaatatt taaagaaaca gtcactttat ctaaacgaaa
      421 atgaaaaaaa taaaatagat acgatacttt tcaaccatca atataaaaaa aatattgtga
      481 ttcgaaaagc agaggctatt caatctccaa taactttttg gtatgggaaa tatattattt
      541 tgattcctag ttcatatttt aaaagtgtaa ttgataaaag actaaaatat ataatactgc
      601 atgaatatgc tcatgctaaa aatagagata ctttacattt aattatcttt aatatcttct
      661 ctattattat gagttacaat ccattagtac atattgtaaa aagaaagata attcatgaca
      721 atgaagtaga agccgataga tttgtcctta ataatattaa caaaaatgaa tttaaaactt
      781 atgcggaatc tattatggac tccgtattaa aaacctcatt tttcaacaaa aatatattaa
      841 gccattcatt taatggtaaa aaatcattac tcaaaaatag attaattaat ataaaagaag
      901 ccgatctgaa aaagcagtca aaattaattc taatttttat ttgtattttt acttttttta
      961 tcatgataat tcaaagccag tttttaatgg ggcaatcctt aactgattat aattataaaa
     1021 agcccttaca aagcgattac caaattttag atgaaagtaa aaattttggt tcaaatagtg
     1081 gatctttcgt tatgtacagc atgaagaaag acaaatacta tatttataat gaaaaagaaa
     1141 gtagaaaaag atattctcct gattcaactt acaaaattta tttagcactg tttggacttg
     1201 accgtcatat tataagtgat aaaaattcac gtatgtcatg gaatcataaa cattatcttt
     1261 tcgagtcttg gaataaggaa caagatttaa atacagcaat gcaaaattca gttaattggt
     1321 acttcgaacg tattagtaat caaataccaa agaactatac tgcggctcaa ctcaagcaat
     1381 taaattatgg taatgaaaat ttgggaagtt ataaaagcta ttggatggaa gatagtttga
     1441 aaatatctaa tcttgaacaa gtaatagttt ttaaaaatat gatggaacaa aataaccatt
     1501 ttagtaaaaa agcaaagaat caattatctt cttcattatt gattaagaaa aatgaaaagt
     1561 atgaactgta tgggaaaaca ggtacaggta tagtaaacgg gaagtataat aatgggtggt
     1621 ttgtaggtta cgtaattaca aatcatgata agtattattt tgctacacat ttatcagatg
     1681 gaaacccgtc tgggaaaaat gctgaattaa taagtgaaaa aatattaaaa ggaatgggtg
     1741 ttttaaatgg ccaataagca agttgaaata tctatggctg aatgggatgt tatgaatata
     1801 atatgggata aaaaatcagt atcagctaat gaaattgtag ttgaaattca aaaatataaa
     1861 gaagttagtg ataaaacgat tagaacatta atcacaagac tatataaaaa agagattata
     1921 aaacgataca aatcagaaaa tatttatttt tactcatcaa atattaaaga agacgatatt
     1981 aaaatgaaaa ctgctaaaac ctttcttaat aaactgtatg gagggatatg aaaagtttag
     2041 tgttgaattt tgcgaaaaat gaagaattaa ataacaaaga aattgaagaa ttgcgagata
     2101 ttttaaatga tattagtaaa aagtaattag aggtatgttt caaacataat acatatgtaa
     2161 actatgcttg actcttatta aattagtttt gttaatgaca tttaaaatat attattaaag
     2221 atgagagtgt acagaaaata accattttct gtacactctt cttttatgtc taaataagta
     2281 agaattacat aggattatgt gttcaaaaac ccaacaaaaa atctatgttc ataaaagacc
     2341 ttgtaattaa gttatggtac actgaagatg tatataggag gtttgtattt tgaaaatagg
     2401 ttatgcaaga gtttcaactg gattacaaaa tttaaattta caggaggatc gattaaatac
     2461 atatggttgt gaaaagatat ttaatgacca tatgagtggt tcaaaaagta aaagacctgg
     2521 tttagataaa gcaattgaat ttgcgaggtc aggagatacg attgttgttt ggagattaga
     2581 tagattggga cgtaatatgg aggatttaat cacattagtt aatgagctta acgaacgagg
     2641 tgtaagtttc catagtttag aagaaaatat aacaatggat aaatcaagtt caactggaca
     2701 attattattt catttattcg cagcatttgc agaatttgaa cgtaatttaa ttttagagcg
     2761 ttcttcagct ggccgaattg cagcacgtgc tagaggccga tatggaggca gaccagaaaa
     2821 attaaatcaa aaagatttaa acttacttaa gaccctttat gataatggca cgccaattaa
     2881 gacaattgca gaacagtggc atgtttcacg tacaacaatt tatcgttacc tcaataaatt
     2941 ggaggacaag gaagatgaaa aacaaggaga agtatctaac taatttttct gaagccaaac
     3001 gtaaaaaagc tactcaaaag tacaatatta taaaaccttt tatcctaggc gaacaatctt
     3061 tatcaagtat ttctaaaagt aaagggattg cgttaagcac cctttatagg tggaataagt
     3121 catataaaga acaaggactt aaaggactaa tctatgcgac aagagctgat aaaggaacac
     3181 gtaaaataga accaaagata attgatgaaa ttgaacgcct tgcgcttatg aataaaagaa
     3241 atagtatagc cacaattcat aggaaaatca ctaattactg taaagaaaat aattttgata
     3301 taccaagtta taaacaaatt tatagtgtta ttaaagcgat gcctaagtct gttattgatt
     3361 tctctcatca gggtgaaaaa tactatcaaa ataagtacga tttaatacaa attagagaat
     3421 cctcgagacc caatgaaata tggcaagcag accatacttt gctagatatc tttatattag
     3481 accaaaaagg taatatcaat agaccatggc taactattat tatggatgac tatagtcgtg
     3541 caattgcagg ctatttctta agttttgatg cccccaatgc tcaaaacaca gcattaacac
     3601 tacaccaagc aatatggaat aaaaatgata ccaattggcc agtgtgtggt atacccgaaa
     3661 aattctacac agatcatgga agtgacttta cttcacatca tatggaacaa gtcgctattg
     3721 atttgaaaat taacttgatg ttttcgaaag ttggtgttcc tcgtggtcgt ggaaaaatag
     3781 aacgattctt tcagacagtt aatcaaactt tcttagaaca actgcctgga tatataaaca
     3841 ataatgatac tcctagtaat ctaataaatt ttcacaattt tgaagaaaaa ttacgttact
     3901 ttttaattga agattataat caaaaagaac atagtactat tcataccacg cctatcagtc
     3961 attggaatag taatcacttt ttccctaata tgccaagtag cttagaacaa cttgatttat
     4021 tattgttgga aatacctaaa tctagaaaag ttcattcaga tggcattcat tttcaaggtt
     4081 ttcgatacag taatactaat ctagaagctt atgtaggtga atatgtactg attcgttata
     4141 acccaaatga tatggctgaa atacgtatgt tttatagaga tgaatttctt tgtactgcta
     4201 tatgtccaga aatagctgat tactccatag atataaaaga catacagcac gctcgtagtc
     4261 agagaagaaa acacttaaaa caaaatattg ctagtccaag taccacggaa ttaattaagg
     4321 aagaaaaaaa ttgtggttat tcacctcaag aaacgactaa aaacgtcaaa aaattaaaga
     4381 gatatcgtaa tgactaaaaa tcaaaatttc attgaaacga aagagtataa acgctttgct
     4441 gaattttgtg atgcttgtat taaatatcag tatattggta tatgttatgg tcaacctggt
     4501 gtcggaaaaa ctttatcgtc taggtattac acaaattggg atactattga aaaacaagtt
     4561 aaccatagag gttgggaaga tttagctagt aaaacgaccg atgacatact atcggtggat
     4621 aaaatatttt ataatgcacc agcagaaaaa caaactaaat taaggaatga tttatatagt
     4681 attactgcaa tcattgattt gggtcaaaaa ttacatgttg taaataagta tggacatgaa
     4741 catagtaaac attatagtga tatgtttaaa tatattgatt taattatagt agatgagatt
     4801 gatcgcctta aagtgcaaca tttagagcaa ttaagagcta tttatgatga acataattta
     4861 gcaatgatat ttattggtat gccgggtata gagaaaaaac tatctcgtta tcctcaacta
     4921 tattcgcgta taggttttgc gcatgaattt gataatctaa gtaaagatga gacgcatcat
     4981 atattagaat gtaagtggca agacttagga tttgatttaa aactcgaaga ctttactgat
     5041 tatgaggcaa taacgacgat tattaaaatt acaaaaggga attttaggct gattcatcgt
     5101 ttatttgcgc agatagacag aattatggat ataaatggtt tagataaaat aagtacagaa
     5161 gttgtagaaa cagctagaga tagtttagtt ataggtattc gataatagaa aaagcaacgc
     5221 attttaatat agtgcgttgc ttttctcatt tattaggtaa agtcattctc atatatcgag
     5281 taaagtgaca acaattatat atgtatgatt agggtgtact tatatcattc atataaatgt
     5341 ttatttatac cctcaataaa aatattatat gcttttaagc acctatcaca ttccttataa
     5401 aaatgtttat tcaatccttt aatatcgact agcgtagcct tataattttt ttgtaacaat
     5461 tttaaatcct cttcgtaaaa gcttaattta aaatgaccgg cttgagctaa tggctttttt
     5521 ccttgtttaa ttaaaatcaa tatgtttttt aaatgtttta aaaagttttt ataatcataa
     5581 acttttattt tcatgaatga tttatgtgga ttattttcat aatttagcag gtagttttct
     5641 atatcttcaa tataactatc atcaaatggt gtgtgctgga aataaaaagt ttttacatac
     5701 atgaatattt tataaagttc ttctttcaaa aaatcatatg tatctaaatc tctttgtata
     5761 gcatccaatt tttttaattt ttttacattt ttaccacaat cctgtactct tatccatcca
     5821 ctattttctt taatttcact aggtacactt tgcattaaag tctgagatac tttacttttt
     5881 aattccgaaa tatcattaat atttggacta attagtctat tttctttaac ttttgtctta
     5941 aactcatcta attttttaga cttttccgcg gattcggtag atgctttatt catctcaaaa
     6001 acatatatag gtttacctaa agatttagca aaattgtact ccatttctgt atagctaata
     6061 ttttcttcac tatcaattgt tccataacta gaacctaaca ataatatcac tgcatctgat
     6121 tcattgatcc attgtgttat tatttcccat tggcttttac tacttgagtt aaaaagttcc
     6181 atacctgctg gaatattatt actgtttaaa actgcttcta ctactgcttg acgctcttct
     6241 attaaatcta aataagttga tgaaataaaa atttgatatt taattttagt attactcata
     6301 tatgctcctt taataaaaaa tcaatttaca taaatatatc atatgataat atccaaaaag
     6361 actacttaaa atattatctt tttgcattcc tctactaacc agtgttataa tctagataac
     6421 gaaaatgatt aacaattaat gcaccaatcc ccacactact gcaatagtgt ggggattttt
     6481 tcgatgctgg cttataaagt cgcctattaa ttatttgttg cgtttactaa gccaataagt
     6541 ataatacgca acagcacagc cactgatgac tggtgctatg atgtgaacga aaatgattag
     6601 caaagtaatg cacctcctct ctgcgtctga attgacgcct gagagatagg cgacctgtat
     6661 attatatcat ctccgaatat acgatgatag ataacttccg ataagtcgtc ttatgttata
     6721 taactttgtt ttttatagta tcaagacaag aagaaactcg tttcactcgt ttcaaaaacc
     6781 ctcctgattt ttagagaaaa actctcttat ttcatcgtct ttaataaaat aatatgccat
     6841 ctttccatct ttataaaaat caagtacctc atttttatat aaaagcctta aatgatgtga
     6901 agttgaagca acactcattt tcaatatcaa agaaatatca caaacacaca actcatcttc
     6961 tttaatcaaa gataatatga ttttcaattt cttctcatca caaatttttt ctaaaatgtt
     7021 aagtaatttc ttagatttat catcttctaa aaaacttaaa gcattgttaa ctttatcctc
     7081 atgtacacag atcacatcac aagtattttc ataactcata taaaatcaca ccctaaatta
     7141 aaatataaat cctaaaattg tttgaatagt gtcattttca ataataataa ataaacctaa
     7201 agctatataa atgatagcca taatccaacg actaaatttc tcaacaattt ctccaattcc
     7261 tgggatatta gctaattttt gtgcagtaaa caccaagaag aaaattaaaa ttaaaaagac
     7321 aaacagagta agtaataaat tagtaacact taatgtcaca aaataaggaa caaataaacc
     7381 aatattatcg gcgccacaac ttgctatcgt aacaattgca accgtaccaa ctaatttaga
     7441 caatcctttt tcattcaatt cttttttagc tctcttttct ccttcacaat catcataaat
     7501 agccacttta attccaagat aaattggtat taaacccaat aaacctaata tccacttttc
     7561 tggaacataa tttaatacaa aagctaaaaa caaactaact aatattaaaa taatagaccc
     7621 taaatattga ccaacataaa tatttctata ttcttttcta gtctttgctc tagcaaaaaa
     7681 tattaataaa attactaata aatcaactgc tgtagcaata taaagaacag cagcagcaac
     7741 aaccgtttga atcataatac acctcattca aaaatatttt tgaatgtatt ataacttata
     7801 tttttaaata atcataggtg ctttattcca attgctttat tgacgttgag cctcggaacc
     7861 cttaacaatc ccaaaacttg tcgaatggtc ggcttaatag ctcacgctat gccgacattc
     7921 gtctgcaagt ttagttaagg gttcttctca acgcacaata aattttctcg gcataaatgc
     7981 gtgtctatgc gtagacatgg agacacttca gaattatgga gtgattacat gagtttaact
     8041 atttttcttt attcagtttt aggaagttta ttagcaaatt atatctacga aaaatcttca
     8101 aaataaataa ctttttcggt tctactttgt acactttatc tacctggtag acctaattgt
     8161 tattgcttta caggtctaaa attcgtcgtt ataatctagt taaatcccgt aagggcgcac
     8221 ttatacgtcg gataaatcga catgtgcaaa aacgtaatcg accttcgtcg atttttttat
     8281 ttcaaaatta aagaaacggc ttgagatatt ccgagcagtt ataaaaatta atttgcgttg
     8341 aatattgcta ctacattctt gaaaaagtga tgtagattta tagcccataa cttttttgaa
     8401 ttacatcgac gatacggcgt cgaaagaaaa agctacctca ctttatctgg ggggctttta
     8461 ttttttatgc ccttattttg aattttaaga gggcatttta aagatttagg ggtgattcat
     8521 ataagtttta tctaaaactt atatacgctt ttaaaacgca aatatgagcc aaataaatat
     8581 atgctatttt caaaaacaaa aatttgagca aaaacaataa ctatttttta gacactgccc
     8641 atttacatgc aaattaaaaa attagcataa aattctttaa aacttcccca cgttcttcta
     8701 aattcctgca gggcttttct tatcaaaaac ttagaaattt taatttaact ctaaaatctc
     8761 cgtaagagca taagggaaat ttgtccccat caatgaatgg gggatctggc aaagccagat
     8821 atttcaaggc ttcgaaaatg tttttgtgtg gggtcataaa aagctcaagt gtcacacttt
     8881 tgtgacacta catacagcat ttgtcacaaa aataagacag cacttttttt acaaaaaagt
     8941 aataaaaaaa gacatcagtt atcactaatg ccttaaataa taattttgct tttcaaaatt
     9001 gccgtaatcg aatgtgcctt ttcttcttca tttgctattt tatcttcatc acttgtatta
     9061 attaaattgc catcttcagc atcgtctaag tttaaaattt tatgttttta tttaagcaat
     9121 ccaccataac ttaacatacg ttttcgatac aaatcttttt ctagatcact gacaatttct
     9181 tgattttttc atcgctatca gttaaaaagt cagatgattt aacgaaatat tttgatgtat
     9241 ctttgattgt tataaaatca tttgaatgat tgattaaaga tattatattg tttcatgttt
     9301 ttacggcgca tataaagtgc atgtgtttct tcaaattcag ttaaaattgt ttgcattaaa
     9361 taaccttgca ttgacttgaa tgattactaa tttcattttc ggactctata tcattcaagt
     9421 cattcatatc atttatttca gtattgttag attcagtata gctaagttca gtatcattag
     9481 attctgtttt atcgacttct tgaagtcggt ttttccgact tccttgccat tgctgctctc
     9541 aacagtgttt tcttgctttt gaattttata aatatcatct tctgttactt ctggtttaac
     9601 taaataaagt ttatttgtct tatttaaacc ttgtctttct tgtagtagta attcggcttc
     9661 aattaagttc tttctttatt ttaattactt tatctttttt acaatttaat atattttgtg
     9721 ggttttcatt tttgtaataa aaataaatat tacctgtttt agaatcaacc caaccatttt
     9781 taattgataa atctaaacga tctctaagaa taccccatgc catttttgca tcattggata
     9841 acttgatata tttaggattt gtaaaaaata ctttcggtat ttgataaaac ttttctctgt
     9901 attcctcatt tatgttgtaa agtttaattg acataataaa aacctctttc cgaattttag
     9961 tttggtaaga ggtaataaaa cgcttacatt ttttgtgttt atttaataat ctaggtgctt
    10021 gcactaagat attattcatt atataatcta agtatcgaaa attatataaa taaacagttt
    10081 ctaaacgttt tattaccaaa ccccgactat taccagtagt tggggttttt gttatattaa
    10141 ggttattata gcactttgaa taaacttaaa aaagggaaaa tataggttta taaacctttg
    10201 ataaacacca taaacccttt acaaaccctt gataaaaagg ttggcgaatt tatattttta
    10261 tttgtcgatt actttattat taatcgttat aagcttataa tattttacta agggtttata
    10321 aacattttat aaagggttga tgatatgaaa agtgtaaaaa ggttgagtga agaattaggg
    10381 gttagtaagc aaacgatttt taataatatt aagagattga atatagagac aataaaacag
    10441 gaaaacactt cgtttattaa agaagatacc gatatagaaa aaatcattca aagagtaaat
    10501 gaaaataaaa agaaatatgg ttttgaaagt gctactgaag acaaacaaaa aaaagagtcg
    10561 gataatatta attttgaatc taaaagcgat gctcaaatag tagaaatact taaaaatcag
    10621 attaatactt taaataatca aattgaaaaa caagaaagtc gtcatgaaac aacaattgaa
    10681 ttttacagaa aagagttgca agaaagatca aaattgcttg agaatcagca agttctggca
    10741 ttagagagta ataaaaagat tcaaaaatta gaaaatcaat tagaaaaaga aaaacacctt
    10801 aattatccct ttgatacatc tactaacgct agacaaaacg ttgatgcaca agaaaaaaca
    10861 tatactacta gtcctgtaaa tattaaccga gatcaggaag aaactaaaga aacagagatt
    10921 caatataagg atatatctgg aagtcaaagc gacgaaagta cacaaggtga agaagcacaa
    10981 agagaagacg tttcagctaa tccaaatgac aatgatagtg atatagaaga aaagagtgaa
    11041 gaaacggaag ctaaaaaggg gttttggagt cgtctatttg gtaactaatt ttaattaaaa
    11101 aggtacgaca agttcataaa ttagccgtgc ttttttatgt gaattgaact tctgataatc
    11161 atcgattata ttaaccaaac aaaaagccat aaatgcctat atgacggcat ttatggcttt
    11221 ttactttcat tatcttttat gcatctttta tacatcgttg atttgacgcg ttttcattct
    11281 tttgcattgg caagtatttt gtatctttat tcagttacta tttcttttct ccaacctaac
    11341 aaaccatctt taactctaat aatatgtttg ccacgccaga cacttcttac ttcgaaataa
    11401 taccattccc cgtttttgtt gaggaaataa atatcttgat aaccttcttt aatgacatat
    11461 tttgtagctt cttgtctttg atcgccaaac attatcaatc ccacccttat atttatttat
    11521 ctttaatata taacaacatt tattaatatt catgttattt catggaagga gagatttgtt
    11581 ataatgtgaa ggtcgtctat ctctcagatg tcaattcggc gtagagagga ggtgcgattt
    11641 atgaatgaaa ttcttgttca catcatgaca acggcaatca gtggttgtct cgttacgtta
    11701 tttggttatt agctccataa acgtgataaa aaataatata gacgattaaa gccaattcac
    11761 caaaaaaccc cgaactacgg cgaatagttc gggtttggtg cgtttacaaa cgaaattctt
    11821 gttactttta gtatatattt catattgcct tttgtaaact cttctattct tatcaataca
    11881 tttcaaggtg tcgtaaaaat actttccttt ttcatattgc ctgatgtgca ttaaattttg
    11941 attttaaaat caacccatga acgaatgaat ggcccaaact aaaaatccgg caacaggaaa
    12001 gaaaagccac caaaaatcat aaagaaaatc aactatggaa ggtaccctgt tactctctct
    12061 ataatttccc tctaaaataa cttttttaaa acgtgcatct cctttaatta aatgctctaa
    12121 agagattccg aataaatcgc tcatagcaat caaaatatct aaggaaggat agtttttggc
    12181 actttcccat ttagaaacac tttgtctgga aacctttaat atattggcta attcctcttg
    12241 agaccatcct tttaattctc tctgttcttt tatagcttca gctaatttca taaaatcact
    12301 ccttaactca aactataatt aaaataattg aaaagtcacg atacttttag ttaaccaact
    12361 cgcaacgaaa agttgcgtta ttcccaattc agttcaagtt gttttaaaaa atcctctcgt
    12421 tctttctcta attgtgggtc gtaatctttt tgaggttgct tttcatatga ccgttcttct
    12481 aaccatttag gcgtcttttc acgcctcaca tattgtcttg atttatctat cttggacatt
    12541 tgaggttgtc gtttgttatg aatgcgtttc tcagcgtcaa atgtgaactc tatccattca
    12601 attttacgcc cttttttcgc tttgatttta ttgatagtaa gattattaaa tatagaacct
    12661 aattcaataa taataggttt aaaaacattt ttgttaatat cagtcatacg ataagattta
    12721 ggtatatcta aacgattttt aaaatcatcg atgtgaattt ttaaatagcc tgtatgtttg
    12781 tattgtttaa gtaatctaaa catattttta gaatatgtag atttaagcct agtcatttct
    12841 tttaattcaa attttgtaaa attattagta attgaattca atatgtgttt taaatttgaa
    12901 gaagttgata tttctagata ttgttctcgc ttatggattc tataatgatt gaataaaacg
    12961 aatctttcta ttacatcatc atcttcatat ctaatggtta aattcaacat ctttttatac
    13021 acattatcta aatcattagc aaatctatta atattacgtg tttctggact ataattactt
    13081 aattttttta attcatcaaa agacaaacgt aatgtattag tatcttgctc ttttaattta
    13141 ttacacatcg caaaaaataa attaatttca gtagctgtaa atcgccttaa tggaactaaa
    13201 ttcatttcat ttttatatac aactgtctct cctgtcatga tacagccccc tttattacga
    13261 acctaaagga gtatcgtttg aatatacact cccatttgaa aacttttatt cacaataaac
    13321 tactttatta tcaatgtcaa accataaaag gagtacaact ttttaaaaca ctccttttat
    13381 gtggcaaaaa cactcctttt atgtggcaaa aacactcctt ttatgtggca aaaacactcc
    13441 ttttatgtgg caaaaacact cctttaggca ttgaaatccc ttgttgctct agggctgaac
    13501 aagcccctaa aaaggttttt aaaaagattt ataaaaatat attaaaaagt tcgagggggc
    13561 tacctatttt tcatcctaaa aaataattaa cctcaaacaa atgcatttaa atatctattt
    13621 ttataatgta taaccatctt ctctatcttc tttaaaaatg atttctcgtt cttgtgcttg
    13681 atatttcttc ttaaagaact gttcatcatt gttatctatc gtcattactt cacgtatttt
    13741 agaattgtct aaatgattat caatatgatt tattagtgta tgataacgct cttctttcat
    13801 catactttta atgattttaa aaacttgatt gaataactta agcgtataat ttagttcttt
    13861 atctttcttt tcattctctg acaacaaata attataacgt tgtgctaaat cattaaattc
    13921 ttcaaccagc ttttcatttt ccatatggac actagtcaat tcattaacta aactttcatt
    13981 ttgtttctct gcttttttta atgacttccc acttttaata cattcataat catctaatat
    14041 catctgtgct gctttaattt gtttagtgta tttttcaaaa tcagttttag taattacaat
    14101 attgcctgtt tcttgcttct ctttatgaaa ccatccacct acatttttgg ttttaatttc
    14161 atacatgaca ctcagaagct ttttaagcgt atctaatgat ttttggtagt tttgtatcaa
    14221 tttatcattt tcttgcttta aataatcctc tatttgcttc tagcgcatat gcatttgttt
    14281 atgatattct gttttttgtt tataacggct aacttgatca tgtttttctt ttgtaagttg
    14341 tctagaaatt cctcgtttta aatcatagcc ttgcttatta atatacgtat tgaatctatc
    14401 ttggaattcg gttaatgctt ttttattacc tacaacttct ttcgcactta aacgtccatc
    14461 tttagtaata ggaactacgc cataatgcat atgtggtgtt atctcatcca tatgtactgt
    14521 cgcatataaa agattttctt taccgtattc ttcttccaag aacgctttag catgcttaaa
    14581 aaactatttt gtctcttctt cagataattg attaaaaaac acattatctg atgtaattaa
    14641 tccatcaata tgtttaatgg catctgttct aattttgcgt ttccctttat aatttttttc
    14701 gattttctca tcaatttttt tattaaaatc aaacttagta tcattgacta aatcatagtt
    14761 taaatatgac ttacttaaat caatatctat attttcataa tttttatttt ctctttgaat
    14821 atgtctttga atacctcttg tatttgtttt tgatttcact ttaacaactc gaataattga
    14881 ataagacata ataaatcaac ttccactgca tatgattata acacctaaac acagaaaagt
    14941 tttaacatac tagacttatt aaaaaccaaa taagtcatta aaaacgtgtg ctctgcgagg
    15001 cttgtttttt gtcatcataa aaaaggactg gaaaatccag tccttaaatt aaaaaactca
    15061 aaagtaatga ctaatcatat ttcatattgt tttttctcta tgtatggcta tacctatcaa
    15121 tatttcttaa cttctaagct cagaaatatt gactatgaca tcaaatcgtt tcgcaagctc
    15181 taaatcatgc gttacgacaa tcatagtttt attttcatca agtagcttca ataataaatc
    15241 aataactatt tttccatttt tcgtatctag tgacccagta ggttcatcag ctaaaatgat
    15301 tttcggatct tttaatatta atcttgccaa tgctactctt tgttgttcac caccgcttag
    15361 agaactaaca attctcttga tatctaaatc taggccgacc ttttttaata cttctttctt
    15421 taagttcata ttatcttttt tattcttttt gaactttagg gctaaatcta aattttgact
    15481 gattgtttga ttttcaagta aagcaaaatt ttgaaacaaa taccctaacg tatatctata
    15541 aaaatcgact ttctttttta gtaacttatc ttcaatatat atgcttcctt gtgatacatc
    15601 ttcgaaccca gcgattatgt taagtaaagt agattttcca gcgccacttt ctccaactaa
    15661 agcatatgat tttccttttt caaaattaaa gttacatccg tctaaaatgt ttttattacc
    15721 tttttttaca aaaacatttt caagttttat cactatcggt cacctcattt taaaaagcta
    15781 ggaatatctt ttgtaatgta ttctatcgaa cgcacatatt tccctttatg atttactttc
    15841 acatattctt ttgtaggatc ataacctaaa aaatccaatt tataactctt tttttctcca
    15901 tttttagagt atacagttat atttctatag tcctgggtat cttttggaac tttggcataa
    15961 gatacttttt cttttaacag tgggttaaaa cgatctaaat gctcatttct aaccaataac
    16021 agactaagta tgatgattaa tagtacaatt gttacaataa ttaaagttct tttcattgtt
    16081 taaatctccc tcattaaatc tttaaagtat ttttcaagat atttaatata agcaatttga
    16141 agtaaatgtt gaataatagc aatagacatt attatgaata gtaatatctt tgaaccaaat
    16201 aaaatatgcg tagtgtaagc taacataata gaaagtaaga tagaaattgt taaataacgt
    16261 acattactgc tgaataatga ataaccatga atttttctta ataatagttg ctttttattc
    16321 cagctaaaat attgaattgt ttcaaataca gtagctatca aaagaatgaa aacgttaata
    16381 ataatagtaa ctattgttat tatcattttt gttttcgttt catttaattc atttaacaca
    16441 gaatccttgt aattagttat accgctaatt tcttcttcta ggtgattatc tttaagcaac
    16501 tgtttaagtg tatctaaatc tttaaataga tatccacctt gagaaacagc agctaaataa
    16561 aaatctcctg ttaaatcgtc aagtgtcaac aacattacta ttggagaatc tagataccca
    16621 aatttcaaat tagttgtgcg atcaaaagaa aaaacagata cgttttttga cagtacttgc
    16681 acatctactt ttttgttttg ttgcttttga aagtcaatcc atccttggtg atttttttga
    16741 atttcagatt tttgatattg taaccttgga ggaataaaca cgtttatttt atccgaatga
    16801 ttgtcaatca ttttaaaatc atgatttata tttttataga aattcagaaa attgttattg
    16861 ataaaaaaga cattgccatt ttcaggaatg taattgtttt tatcgggatt ggctatatta
    16921 ttattcttta aaagcaatcc accaagttgt tcgcttttct taattaaatt gtatatatta
    16981 gtttctaaaa tttgtttttc ttctgaattt ctaatattag gagaaatctc taatgtatag
    17041 taattatcta acttttgcca gattttttca gagtcatata tattctttaa cttcgtataa
    17101 gcatttaaat tttgtgccag taaaaaagat agtattagca ccatgataca tttggtgaag
    17161 gtacccataa atattgaaaa cttatatcct tttttccctt ttaagattaa tggaatactt
    17221 aacttcaaaa gaagactata cgaaatcagc cacagcaatg tagtaataca agcaaaaaca
    17281 aaaagcaaca cgataaatct acgaataaac attaagaaat ccaattctaa attggctata
    17341 tgaatgatta atatattagc aataaagaaa atagcggtaa gtactagcca ataaatgatt
    17401 tttatatgaa tattatgaaa aataatgcgt gtagttgaaa agccatgtag cttttgaata
    17461 gcataaaatt tcaaattata tcctctgtca tataagaagt acaaaagata taatacgcct
    17521 aagaatatga aaggcactaa taaatcatta tctatgacta attcaaaaaa taatatgttt
    17581 ctatttatgt attcaacttc agatgttaaa ccagcttttt ttaattcact cgtaagctct
    17641 tctacattga aatgttcacc aataatataa tactttcctt ttatctctct gtttaataaa
    17701 tctgatggag ttaaaagtga tgttttatta cgtataaagt cagaattatt tcgttttgag
    17761 ttgaaaacaa aaaattcttt tttattatca aaatctttaa cggatttaat tatttgtata
    17821 ttttgatttt tggcgcctga ttcaatgaca tctaacactt ttgatttact gttagattta
    17881 tcccaattag agattgttaa aatattggaa ctttcaggta taatttcttc attttctttg
    17941 aagaaaaata aaaataatag ccctgaaatt aataataaag tactaaaatc taaaaataat
    18001 ttgaattttt tcatattgcc tctttcaaga gaatagacag aattaagttt acttaattct
    18061 gtctattctc cttaattaat atatgtaatt agtgaagact ataaaatgtt ttgtttccac
    18121 cccaagcctt tggagcagat gccttagatt gaacaccagg tcgagcaaca ccactaaaag
    18181 atgaatattt ccctactgct gttgaaccat gatttctttt attgtgacta taataagacc
    18241 atacgtaatg ttttccaata ccatggctcc aaacaccacc agctacatgt actgttgcag
    18301 cttcagcttt ataagttaca cctaataaag tgccgaataa gattgtacta gcaatacaac
    18361 tagaaacaaa tttctttttc ataaaaacac ctccatttaa tattctttat ttattatagc
    18421 aaaaataaat aaaatagaga atgagtaaaa ataatctaaa agtgtttttt ctgctctgtt
    18481 gcttgttttg ttcatctata tataatatta attctattat ccttaaatta actatcatta
    18541 aacaacgata tgacaatgta taataaatac aatttcacta cctataattc aacattatat
    18601 aaactaaagt atttcaaata attaactgta ttaatactct catcatgatt gcgttataaa
    18661 cgttcgttaa tgagaaaaag agagagcata tttacgctct cttttcttgt cttattatta
    18721 aaaactcata atagattata atcatctgtt ttgagacgct gtgagaagct ctcagttgca
    18781 ttgaaacaaa gtttattaaa tcaaatcatt atcgttttta attctgtaaa tcgtctgcct
    18841 tgttatattt acttctttcg caattttact aattgattgg ccttcttcta acatttctac
    18901 aacgcgatga taaataatac gtttctgtgg atctttagca tttggtgaat aaagtaaggg
    18961 gcgcccttta tatacgcctt tttccttcgc aacttgaatt ccttgcgctt gtcgacgttt
    19021 actttcattt ctctcttgtt ctgaaaccat tgctaatatt tgaataatta aatctttcat
    19081 aaacttatcc agtaatggat tgccaaccac ttcatcataa ttacgaccta aacaatcaat
    19141 ggattctact acaaaccgat ctcccatcct caaaaagtta agtgcttctt gaagtactgg
    19201 tctattttca atagatttcc cagactgttt ttctgtaaat attttttcag cacaaaacgt
    19261 ctttaaattt tcaagttgtc tttctaaatt ttgatcgttc gatgatactc tcgcatagcc
    19321 aacaatcatt gatttccatc tcataattaa tatacaccct aatcatacgt ttcagttact
    19381 ataaattcaa caattatgtc actttgcttg atatatgaga attatttaac cttataaatg
    19441 agaaaaaagc aacgcacttt aaataagata cgttgctttt tcgattgatg aacacctata
    19501 attaaactat tcatctatta tttatgattt tttgtatata caatatttct agtttgttaa
    19561 agagaattaa gaaaataaat ctcgaaaata ataaagggaa aatcaggttt tgatatcaaa
    19621 attatacatg tcaacgataa tagaaaatat aatacaaact ataagatgtt atcagtattt
    19681 attatgcatt tagaatatta aaattccttc attacactct tggcggtttc acttatcaac
    19741 ttatcatttg gcttatcact tttattgtct ttattcgtaa aaatgactaa aacaataggt
    19801 tcagattggc ccttaggata aacaaaagca acatcatttc tagaagcata tgttattgct
    19861 tgaccacttt tatcagcaac cttatagtct tttggaacac catctttaat taaagtgtct
    19921 ccgtttttat tattaaacat taaatcaagt aagaaatttt tatttttttt gcttaatttt
    19981 ccatttgcga taagtttatt taaagtcttg ccgaaagcag caggcgttga agtatctttt
    20041 ttgctctttg gcgaatagta atttaattct atctcatatc taactggatt tgttacttta
    20101 tctcctagtt cttttagacg ttgtttaact tttttgattc caccgatttc ttttataatt
    20161 ttattgtttg ctgtattatc actatatgtc attgaagcct caataagttc ttttaaagtg
    20221 atgtcttttc ctacatattt ttctaaaata ggagaataag caactatatc atctttgtta
    20281 atatgtactt ttttatttaa cttattataa ggtacttgtt ctaacaaaat agcactattt
    20341 atcgcttttg aagtcgaagc ataggcaaat ctcttatctg aattaaattt tacttcctta
    20401 ccacttttag tatctaaagc ataaacacca atatgagcat tatatttttt ttctaaatca
    20461 tttaactctt tggcatgtga actgtttgaa ttacatgcac ttaaaactaa agccattaca
    20521 attaaaaata ttaacttttt caaaataaac cctccgatat tacagttgta atttttacaa
    20581 aacaataata ttacaattgt aatattgatg tcaattgttt attataaata tttgaaagaa
    20641 ggtgtcaaaa
//
