LOCUS       CP051913               24647 bp    DNA     circular BCT 24-SEP-2020
DEFINITION  Staphylococcus aureus strain ER11063.3 plasmid pER11063.3A.1,
            complete sequence.
ACCESSION   CP051913
VERSION     CP051913.1
DBLINK      BioProject: PRJNA470993
            BioSample: SAMN14669440
KEYWORDS    .
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 24647)
  AUTHORS   Caban,A.B., Pak,T., Kumaresh,A., Dupper,A., Chacko,K.,
            Sullivan,M.J., Altman,D.R. and van Bakel,H.
  TITLE     PathoSPOT genomic surveillance reveals prolonged under the radar
            outbreaks of nosocomial methicillin resistant S. aureus bloodstream
            infections
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 24647)
  AUTHORS   Caban,A.B., Pak,T., Kumaresh,A., Dupper,A., Chacko,K.,
            Sullivan,M.J., Altman,D.R. and van Bakel,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2020) Genetics and Genomic Sciences, Icahn School
            of Medicine, One Gustave L. Levy Place Box 1498, New York, NY 10029,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 426.140294117648x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/23/2020 10:06:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 3,047
            CDSs (total)                      :: 2,964
            Genes (coding)                    :: 2,892
            CDSs (with protein)               :: 2,892
            Genes (RNA)                       :: 83
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 72
            CDSs (without protein)            :: 72
            Pseudo Genes (ambiguous residues) :: 0 of 72
            Pseudo Genes (frameshifted)       :: 45 of 72
            Pseudo Genes (incomplete)         :: 18 of 72
            Pseudo Genes (internal stop)      :: 19 of 72
            Pseudo Genes (multiple problems)  :: 10 of 72
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..24647
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="ER11063.3"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pER11063.3A.1"
                     /geo_loc_name="USA:New York City"
                     /lat_lon="40.7903114 N 73.9528738 W"
                     /collection_date="2017"
                     /collected_by="Mount Sinai Hospital"
     gene            join(24455..24647,1..2)
                     /locus_tag="HIL00_00005"
     CDS             join(24455..24647,1..2)
                     /locus_tag="HIL00_00005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001004925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOA50642.1"
                     /translation="MNENLEKYIKSLPLLGLLISILLIVLFFFILDVDEDLFVVFLYCL
                     LPLIVNLSIYGFYVFVKRK"
                     /name="hypothetical protein"
     gene            1118..1735
                     /gene="cadD"
                     /locus_tag="HIL00_00010"
     ARG             1119..1732
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            1754..2101
                     /locus_tag="HIL00_00015"
     CDS             1754..2101
                     /locus_tag="HIL00_00015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="QOA50621.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNHEGF"
                     /name="helix-turn-helix transcriptional regulator"
     gene            2258..2350
                     /locus_tag="HIL00_00020"
     CDS             2258..2350
                     /locus_tag="HIL00_00020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="QOA50622.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(2522..3493)
                     /locus_tag="HIL00_00025"
     CDS             complement(2522..3493)
                     /locus_tag="HIL00_00025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="QOA50623.1"
                     /translation="MFNAVVVRKSASNVSYKVEKVDESHLSKGDVLVKVVYSSINYKDM
                     LALQYKGGVIRDYPMIPGIDFAGIVESSSNDKFKEGDNVLVTGYDVGVTHTGGFSEYAQ
                     VPGEWIVPIPQEMSIKESMVYGTAGFTAALSIFELEKYGMNIKSQPEILVSGATGGVGS
                     VAIQILHKIGYENITAIVRKEKQIEIAKKLGAKQVIIIEDDNKPLKKGIFDYFLDTVGS
                     NVTLYGLKRLNYQGVATVCGNVAGNSLNANILPFILRGIKLIGIDSVYVDHNIREDIWS
                     KLANEWNIGNSLLYNEIGFEEFYKTIDQLLKGQHLGRTILKV"
                     /name="oxidoreductase"
     gene            3617..4036
                     /locus_tag="HIL00_00030"
     CDS             3617..4036
                     /locus_tag="HIL00_00030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418035.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="QOA50624.1"
                     /translation="MELDNCINYLLSTSQNRVFKHFKSLLSPYNITPAEYGVLNCLINS
                     NLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRTVLINSTNKAKDLWPTL
                     EKKAYQLNNHYFANLTNEETVVFKKILLKINKTTF"
                     /name="MarR family transcriptional regulator"
     gene            complement(4550..5395)
                     /gene="blaZ"
                     /locus_tag="HIL00_00035"
     ARG             complement(4554..5395)
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.29"
                     /coverage="100.0"
     gene            5502..7259
                     /gene="blaR1"
                     /locus_tag="HIL00_00040"
     ARG             5503..7256
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="98.8"
                     /coverage="100.0"
     gene            7249..7629
                     /gene="blaI"
                     /locus_tag="HIL00_00045"
     ARG             7250..7626
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.21"
                     /coverage="100.0"
     gene            7893..8471
                     /locus_tag="HIL00_00050"
     CDS             7893..8471
                     /locus_tag="HIL00_00050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="QOA50628.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNKQDLNLLKTLYDNGTPI
                     KTIAEQWQVSRTTIYRYLNKLEAKENKNK"
                     /name="recombinase family protein"
     gene            complement(8694..8879)
                     /locus_tag="HIL00_00055"
     CDS             complement(8694..8879)
                     /locus_tag="HIL00_00055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001037130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOA50629.1"
                     /translation="MNKLEKWSLVFIIFTFLSSLALLYFKYNFSSVMPVLSLSILTILI
                     LLTSIITVVSVNDEDT"
                     /name="hypothetical protein"
     gene            9141..9815
                     /locus_tag="HIL00_00060"
     CDS             9141..9815
                     /locus_tag="HIL00_00060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="QOA50630.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            complement(9984..10555)
                     /locus_tag="HIL00_00065"
                     /pseudo=""
     CDS             complement(9984..10555)
                     /locus_tag="HIL00_00065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001079940.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="HTH domain-containing protein"
                     /name="HTH domain-containing protein"
     gene            10535..10723
                     /locus_tag="HIL00_00070"
                     /pseudo=""
     CDS             10535..10723
                     /locus_tag="HIL00_00070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002913594.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            complement(10831..11625)
                     /gene="aph(3')-IIIa"
                     /locus_tag="HIL00_00075"
     ARG             complement(10835..11625)
                     /name="aph(3')-IIIa"
                     /gene="aph(3')-IIIa"
                     /gene_name="aminoglycoside O-phosphotransferase
                     APH(3')-IIIa"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(11718..12179)
                     /locus_tag="HIL00_00080"
                     /pseudo=""
     CDS             complement(11718..12179)
                     /locus_tag="HIL00_00080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000627290.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /name="GNAT family N-acetyltransferase"
     gene            complement(12238..12912)
                     /locus_tag="HIL00_00085"
     CDS             complement(12238..12912)
                     /locus_tag="HIL00_00085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="QOA50632.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            complement(12942..13145)
                     /locus_tag="HIL00_00090"
     CDS             complement(12942..13145)
                     /locus_tag="HIL00_00090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001627151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP kinase"
                     /protein_id="QOA50633.1"
                     /translation="MGFIEQIKAFILGVVEGLTEFAPVSSTGHMIIVDDMWLNTADDLG
                     SASATTFKVVIQLGGSVAKLNL"
                     /name="UDP kinase"
     gene            complement(13159..13896)
                     /locus_tag="HIL00_00095"
     CDS             complement(13159..13896)
                     /locus_tag="HIL00_00095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000369394.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="QOA50634.1"
                     /translation="MDNLLRTEFIKLKRSYMFLISILGTCVAPFMVVVASFISMRTKVP
                     TPNIVFKQLFEEVSLYHMLIIGPPLYGVIIAYLFGREYIEDTLKNLLIIPISRESFLVS
                     KIILLFLWIQTLSVIAWLLTLMLGMLLHFQGLSQSLIIDSFFTFVIGGVLLWILSPPII
                     ILSIYFKNYVPTIVLTIIITLINLMTANSEHRGLFPWAAVGDISRGTLPNTYPFLLSLI
                     IIIVTSIFSVIILFSYFKKTDIS"
                     /name="ABC transporter permease"
     gene            complement(13889..14818)
                     /locus_tag="HIL00_00100"
     CDS             complement(13889..14818)
                     /locus_tag="HIL00_00100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000074567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="QOA50643.1"
                     /translation="MKNLNNIIEINNLTKQYGSQIAVNNLSITVESGQIYGFLGRNGAG
                     KTTTIRMLLGLIKPTKGNIKIFEKEFESNKTEILKNIGAMVETPGFYSNLTAKENLTIN
                     AKILGIQKENAIEEVLEIVGLASEKVKLFKNYSLGMKQRLGIARALLHNPELLILDEPT
                     NGLDPIGIKEIRKLIKDLAQSRNITILISSHILSEIEQLVDKVGIIHNGVLLEEIMYED
                     LKKKNRQFISISVSDEEKVACLLETNFGIYDYKIKENGEFKIYSHIDRQQEINRLLVLN
                     NIDVFQMRVIEDNLETYFEDLVGGGTIG"
                     /name="ABC transporter ATP-binding protein"
     gene            complement(14934..15815)
                     /locus_tag="HIL00_00105"
                     /pseudo=""
     CDS             complement(14934..15815)
                     /locus_tag="HIL00_00105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_501406.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /name="HAMP domain-containing histidine kinase"
     gene            complement(15812..16189)
                     /locus_tag="HIL00_00110"
                     /pseudo=""
     CDS             complement(15812..16189)
                     /locus_tag="HIL00_00110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000866106.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /name="response regulator transcription factor"
     gene            complement(16247..16921)
                     /locus_tag="HIL00_00115"
     CDS             complement(16247..16921)
                     /locus_tag="HIL00_00115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="QOA50635.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            17395..18861
                     /gene="msr(A)"
                     /locus_tag="HIL00_00120"
     ARG             17396..18858
                     /name="msr(A)"
                     /gene="msr(A)"
                     /gene_name="ABC-F type ribosomal protection protein Msr(A)"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE/STREPTOGRAMIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            18960..19859
                     /gene="mph(C)"
                     /locus_tag="HIL00_00125"
     ARG             18961..19856
                     /name="mph(C)"
                     /gene="mph(C)"
                     /gene_name="Mph(C) family macrolide 2'-phosphotransferase"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(20328..21071)
                     /locus_tag="HIL00_00130"
     CDS             complement(20328..21071)
                     /locus_tag="HIL00_00130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002508633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="QOA50638.1"
                     /translation="MKSVKKLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESTTEDKQKKGSDNINFESKSDAQIVEILKNQIDTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNTR
                     QNVDAQEKTYTTNPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAKKEDVPANLND
                     NDSDIEEKSEETEPKKGFWSRLFGS"
                     /name="DUF536 domain-containing protein"
     gene            21497..22480
                     /locus_tag="HIL00_00135"
     CDS             21497..22480
                     /locus_tag="HIL00_00135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="QOA50639.1"
                     /translation="MQNQYFTVQENYKERFYQIPKVFFTSENYKNLTNDMKIAYAILRD
                     RLNLSIKNSWVDEDGNIYFVYSNEKLMEILNCKKEKLTKIKKGLENDGLLIQKRRGLNK
                     PNILYLMKPIVTERDIYKIEKEENDVEPYGEKEVRKSNVQKFENRTSRSSKIERPEVRK
                     SNTNDTDFNDIDFNDTENNDMNDLNDIKYKNEISNHSNHSNQFTHNFDDKEMLLQEFPE
                     QLTNYLLKYDYRDLEIIKAVILKAKKSFNSRHEDMHYMLEDIEDEILTSLKRLKKAIHD
                     RGVKGQKETIKSMQAYLMQTILTELEETHALYMRRKNMKQYNIFNQ"
                     /name="replication initiator protein A"
     gene            22473..22789
                     /locus_tag="HIL00_00140"
                     /pseudo=""
     CDS             22473..22789
                     /locus_tag="HIL00_00140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002483623.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            23336..23485
                     /locus_tag="HIL00_00145"
     CDS             23336..23485
                     /locus_tag="HIL00_00145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000695367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOA50640.1"
                     /translation="MKIKTFATFTHRQLDKQVNRFLKNDIHVLEIQTHSNWLYISAIVF
                     YEDK"
                     /name="hypothetical protein"
     gene            complement(23653..24345)
                     /locus_tag="HIL00_00150"
     CDS             complement(23653..24345)
                     /locus_tag="HIL00_00150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOA50641.1"
                     /translation="MKIIKLFSIISLFLLVFSANFSNAYANEEQKSSLLENQKEKLKSK
                     NIEVSQMTKKEISFLEQLQNKNEDMQKFEKQMKKEGFKKIKLEDKNSKLKYLATEANDK
                     NAYGYIANNAYKNEKTKEIVVSETIYDNYNKKITKFIAEKRSMTENKEGKILINKNYVE
                     YKAEKVDKNRPVTYAGFKWNGKAFACSMAGLYACAHYCGVWAIVNPIAGGVCEAVCGTA
                     FAAGCSVG"
                     /name="hypothetical protein"
     ARG             17396..18861
                     /name="msrA"
                     /gene="msrA"
                     /gene_name="msr-type ABC-F protein"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; streptogramin
                     antibiotic; streptogramin B antibiotic"
                     /identity="98.36"
                     /coverage="100.0"
     ARG             18961..19859
                     /name="mphC"
                     /gene="mphC"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="98.66"
                     /coverage="100.0"
     ARG             complement(4551..5395)
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="95.37"
                     /coverage="100.0"
     Typing          22846..22993
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="5.980000000000001e-72"
     Typing          complement(20329..21071)
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          21498..22480
                     /name="rep_cluster_2100"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.593"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          22612..22781
                     /name="rep_cluster_1017"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="93.605"
                     /coverage="91.0"
                     /evalue="1.04e-65"
ORIGIN
        1 aagattatga ataattttgt ttttaatttg tatgctttga gggggttgga aaacggtagg
       61 tgtatagatt agatttcttg tttttttgaa acgagtgtga acgagtttct tcttgtcttg
      121 atttttgata aaaacgccct acaggaattt agaaaaacgt ggggaagttt taaagaattt
      181 tatgctaatt tttaatttgc atgtaaatgg gcagtgtcta aaaatagtta ttgtttttgc
      241 tcaaattttt gtttttgaaa atagcatata tttatttggc tcatatttgc gttttaaaag
      301 catatataag ttttagatat aaaactatat gaatcacccc taaatcttta aaatgccctc
      361 ttaaaattca aaataagggc ataaaaaata aaagctaccc cagataaagt gaggtagctt
      421 tttctttcat acggtctatt tatttttctt tcgacgccgt atcgtcgatg taattcaaaa
      481 aagttatggg ctataaatct acatcacttt ttcaagaatg tagtagcaat attcaacgca
      541 aattaatttt tataactgct cggaatatct caagccgttt ctttaatttt gaaataaaaa
      601 aatcgacgaa ggtcgattac gtttttgcac atgtcgattt atccgacgta taagtgcgcc
      661 cttacgggat ttaactagat tataacgacg aattttagac ctgtaaagca ataacaatta
      721 ggtctaccag gtagataaag tgtacaaaat agaaccgaaa aagttattta ttttgaagat
      781 ttttcgtaga tataatttgc taataaactt cctaaaactg aataaagaaa aatagttaaa
      841 ctcatgtaat cactccataa ttctgaagtg tctccatgtc tacgcataga cacgcattta
      901 tgccgaaaaa atttattgat gttgagaaga acccttaact aaacttgcag acgaatgtcg
      961 gcatagcgtg agctattaag ccgaccattc gacaagtttt gggattgtta agggttccga
     1021 ggctcaacgt caataaagca attggaataa agcacctatg attatttaaa aatataagtt
     1081 ataatacatt caaaaatatt tttgaatgag gtgtattatg attcaaacgg ttgttgctgc
     1141 tgctgttctt tatattgcta cagcagttga tttattagta attttattaa tattttttgc
     1201 tagagcaaag actagaaaag aatatagaga tatttatgtt ggtcaatatt tagggtctat
     1261 tattttaata ttagttagtt tgtttttagc ttttgtatta aattatgttc cagaaaagtg
     1321 gatattaggt ttattgggtt taataccaat ttatcttgga attaaagtgg ctatttatga
     1381 tgattgtgaa ggagaaaaga gagctaaaaa agaattgaat gaaaaaggat tgtctaaatt
     1441 agttggtacg gttgcaattg ttacgatagc aagttgtggc gccgataata ttggtttatt
     1501 tgttccgtat tttgtgacat taagtgttac taatttatta cttactctgt ttgtcttttt
     1561 aattttaatt ttcttcttgg tgtttactgc acaaaaatta gctaatattc caggaattgg
     1621 agaaattgtt gagaaattta gtcgttggat tatggctatt atttatatag ctttaggttt
     1681 atttattatt attgaaaatg acactattca aacaatttta ggatttatat tttaatttag
     1741 ggtgtgattt tatatgagtt atgaaaatac ttgtgatgtg atctgtgtac atgaggataa
     1801 agttaacaat gctttaagtt ttttagaaga tgataaatct aagaaattac ttaacatttt
     1861 agaaaaaatt tgtgatgaga agaaattgaa aatcatatta tctttgatta aagaagatga
     1921 gttgtgtgtt tgtgatattt ctttgatatt gaaaatgagt gttgcttcaa cttcacatca
     1981 tttaaggctt ttatataaaa atgaggtact tgatttttat aaagatggaa agatggcata
     2041 ttattttatt aaagacgatg aaataagaga gtttttctct aaaaatcatg agggtttttg
     2101 aaacgagttt cttcttgtct tgatactata aaaaacaaag ttatataaca taagacgact
     2161 tatcggaagt agatatgctt gtatattcac agatggtata ataatagagt cgcctatctc
     2221 tcaggcgtca attgacgaag agaggaggtg cattactttg ctaatcattt tcgttcacat
     2281 catagcacca gtcatcagtg gctgtgctgt tgcgtattat acttattggc ttagtaaacg
     2341 caacaaataa ttaataggcg actttataag ccagcatcga aaaaatcccc acactactgc
     2401 aatagtgtgg ggattggtgc attaattgtt aatcattttc gttatataaa ttataacact
     2461 ggttagtaga gaaatgcaaa atgattgaat taatagtaaa tgtattaatg aatactcaca
     2521 cttatacttt taaaatagtt cttcctaaat gttgtccttt taaaagctga tctatcgttt
     2581 tatagaattc ttcaaatcca atttcattgt atagaagtga atttcctata ttccattcat
     2641 ttgctaactt actccatata tcttcacgga tattatgatc aacatataca gaatcaatgc
     2701 caattaattt aatacctcta agaataaacg gtaatatatt agcgttaagt gaatttcctg
     2761 ctacatttcc acatacagta gcaacacctt gataatttag acgttttaaa ccgtataatg
     2821 ttacattact ccccactgta tctaagaaat aatcaaaaat acctttttta agcggtttat
     2881 tatcatcttc aattattatt acttgttttg cacctaattt ttttgcgatt tctatttgct
     2941 tttcttttct tacgatagca gtgatatttt catatccaat tttatgtaaa atttgtatag
     3001 caacactgcc cacaccacct gtagccccag acactaaaat ttcaggttgt gatttgatat
     3061 tcattccata tttttctagt tcaaaaattg ataatgctgc cgtaaaaccg gctgtgccat
     3121 ataccataga ctctttaata gacatttctt ggggaatagg aacaatccac tctccaggca
     3181 cttgtgcata ttctgaaaat ccacctgtat gtgtcacgcc aacatcataa ccagtaacta
     3241 atacattatc gccttcttta aacttatcat tcgaacttga ttcaacaata cctgcaaaat
     3301 ctataccagg aatcatagga taatctctaa ttacaccgcc tttatattgt aaagctagca
     3361 tatccttata atttattgaa gagtatacca cttttactaa tacatcaccc ttcgataaat
     3421 gagattcatc aactttttct actttataac taacatttga tgcacttttt ctcactacta
     3481 ccgcattgaa catttattag ccttctttca caattgtttt gtagaagtat gtttttgttg
     3541 caaaactatt ttcctacaaa acttatcatg atatgataag cgagtcaata ctaatgattt
     3601 aagagaggtt ttagttgtgg aattagataa ttgtataaat tatttgttga gtacttctca
     3661 gaatagagtt tttaaacatt ttaaaagttt attaagtccc tataatatta ctccagcaga
     3721 atatggtgtt ttgaattgct tgattaatag taatttgaat acacctaaag cgattggtaa
     3781 tactttaaat ttagaacctt caacaatatc tggaatatta gataagatgt ccaaaaagga
     3841 tctaataaca cgtcaaactg ataatgaaaa tagaagaact gtgctaataa acagtacaaa
     3901 taaagcaaaa gacttatggc caacattaga aaagaaagcc tatcaactta ataatcatta
     3961 cttcgctaat ttaactaatg aagaaactgt agtgtttaaa aagatattac taaagataaa
     4021 taaaactacg ttttaatttt tacgttataa aaaagttgaa gtgcgaatta taatcgagta
     4081 aatataaatg atagcttagc ttaattatat attaaagcca actatacttt tattcccgaa
     4141 aaacctacta tccaaatttc taagatactt tagcctctat aataaacata ttgtaatata
     4201 atttatgtat tatttaggtt taccctaatc gaacaataaa aaatacttgt aaaatgctat
     4261 tgtcactttg cttgatatat gagaattatt taaccttata aatgagaaaa aagcaacgca
     4321 ctttaaataa gatacgttgc tttttcgatt gatgaatacc tataattaaa ctattcatct
     4381 attatttatg attttttgta tatacaatat ttctagtttg ttaaagagaa ttaagaaaat
     4441 aaatatcgaa aataatagag ggaaaatcag tttttgatat caaaattata catgtcaacg
     4501 ataatacaaa ctataagatg atatcagtat ttattatgca tttagaatat taaaattcct
     4561 tcattacact cttggcggtt tcacttatca acttatcatt tggcttatca cttttattgt
     4621 ctttattcgt aaaaatgact aaaacaatag gttcagattg gcccttagga taaacaaaag
     4681 caacatcatt tctagaagca tatgttattg cttgaccact tttatcagca accttacagt
     4741 cttttgaaac accgtcttta attaaagtat ctccgctttt attatttaac attaaatcaa
     4801 gtaagaattt tttgttttct ttgcttaatt ttccatttgc gataagttta tttaaagtct
     4861 taccgaaagc agcaggtgtt gaagtatctt ttttgctctt tggtgaataa taatttaatt
     4921 ctatctcata tctaactgga tttgttactt tatctcctag tccttttaga cgttgtttaa
     4981 cttttttgat cccaccgatc tcttttataa ttttattgtt tgctgtatta tcactatatg
     5041 ccattgaagc ctcaataagt tcttttaaag tgatatcttt tcctacatat ttttctaaaa
     5101 taggagaata agcaactata tcatctttgt taatatgtat ttttttattt aacttattat
     5161 aaggtacttg ttctaacaaa atagcactat ttatcgcttt tgaagtcgaa gcataggcaa
     5221 atctcttatc tgaattaaat tttacttcct taccactttt agtatctaaa gcataaacac
     5281 caatatgagc attatatttt ttttctaaat catttaactc tttggcatgt gaactgtttg
     5341 aattacatgc acttaaaact aaagcaatta caattaaaaa tattaacttt ttcaaaataa
     5401 accctccgat attacagttg taatttttat aaatcaataa tattacaatt gtaatattga
     5461 tgtcaattgt ttattataaa tatttgaaag aaggtgtcaa aatggctaaa ttactaataa
     5521 tgagcgtagt aagcttttgt tttatatttc tattgttagt attttttagg tacatattaa
     5581 aacgctattt taattatagt ttaaattata aagtttggta tctaactatg cttgctggat
     5641 taattccttt tatcccaatt aaattctctt ttataaaatt taataatgtg aataatcaag
     5701 cgcccacagt tgaaagtaag tcacacgatt tgaaccataa cataaatacc accaaaccta
     5761 ttcaagagtt cacaacagat atccataagt ttaattggga ttcaattgat aatatctgca
     5821 cagttatttg gatagtttta gttattattt taagttttaa atttttgaaa gccttattat
     5881 atcttaaata tttaaagaaa cagtcacttt atctaaacga aaatgaaaaa aataaaatag
     5941 atacgatact tttcaaccat caatataaaa aaaatattgt gattcgaaaa gcagaggcta
     6001 ttcaatctcc aataactttt tggtatggga aatatattat tttgattcct agttcatatt
     6061 ttaaaagtgt aattgataaa agactaaaat atataatact gcatgaatat gctcatgcta
     6121 aaaatagaga tactttacat ttaattatct ttaatatctt ctctattgtt atgagttaca
     6181 atccattaat acatattgta aaaagaaaga taattcatga caatgaagta gaagctgata
     6241 gatttgttct taataatatt aacaaaaatg aatttaaaac ttatgcggaa tctattatgg
     6301 actccgtatt aaatattcca ttttttaata aaaatatatt aagccattca tttaatggta
     6361 aaaagtcatt actcaaaaga agattaatta atataaaaga agccaatttg aaaaaacagt
     6421 ctaaattaat tccaattttt atttgtattt ttactttttt gctcatagta attcaaagcc
     6481 agtttttgat ggggcaatcc ataactgatt ataattataa aaagccctta cagaacgatc
     6541 accaaatttt agatgaaagt aaaaattttg gttcaaatag tggatctttc gtcatgtaca
     6601 gcatgaagaa agacaaatac tatatttata atgaaaaaga aagtagaaaa agatattctc
     6661 ctgattcaac ttataaaatt tatttagcga tgtttggact tgaccgtcat atcataagtg
     6721 ataaaaattc acgtatgtca tggaatcata aacattatcc tttcgagtct tggaataagg
     6781 aacaagattt aaatacagca atgcaaaatt cagttaattg gtacttcgaa cgtattagta
     6841 atcaaatacc aaagaactat actgcggctc aactcaagca attaaattat ggtaatgaaa
     6901 atttgggaag ttataaaaac tattggatgg aagatagttt gaaaatatct aatcttgaac
     6961 aagtaatagt ttttaaaaat atgatggaac aaaataacca ttttagtaaa aaagcaaaga
     7021 atcaattatc ttcttcatta ttgattaaga aaaatgaaaa gtatgaactg tatgggaaaa
     7081 caggtacagg tatagtaaac gggaagtata ataatgggtg gtttgtaggt tacgtaatta
     7141 caaatcatga taagtattat tttgctacac atttatcaga tggaaacccg tctgggaaaa
     7201 atgctgaatt aatcagtgaa aaaatattaa aagaaatggg tgttttaaat ggccaataag
     7261 caagttgaaa tatctatggc tgaatgggat gttatgaata taatatggga taaaaaatca
     7321 gtatcagcta atgaaattgt agttgaaatt caaaaatata aagaagttag cgataaaaca
     7381 attagaacat taatcacaag actatataaa aaagagatta taaaacgata caaatcagag
     7441 aatatttatt tttactcatc aaatattaaa gaagacgata ttaaaatgaa aactgctaaa
     7501 acttttctta ataaactgta tggaggggac atgaaaagtt tagtgctaaa ttttgcgaaa
     7561 aatgaagaat taaataacaa agaaattgaa gaattgcgag acattttaaa tgatattagt
     7621 aaaaagtaat tagagatatg tttcaaacat tatacatatg taaactatac ttgactctta
     7681 ttaaattagt tttgttaata acatttaaaa tatattagta aagatgagag tgtacataaa
     7741 ataaccattt tctgtacact ctctttttat gtctaaataa gtatgtatta catagaatta
     7801 tgtgttcaaa aacccaacaa aaaatctatg ttcacaaaag acctcgtaat caagttatgg
     7861 tacactaaag gtgtatatag gaggtctgta ttttgaaaat aggttatgca agagtttcaa
     7921 ctggattaca aaatttgaat ttacaggagg atcgattaaa tacatatggt tgtgaaaaga
     7981 tatttaatga ccatatgagt ggttcaaaaa gtaagcgacc tggtttagat aaagcaattg
     8041 aatttgcgag gtcaggagat acgattgttg tttggagatt agatagacta ggacggaaca
     8101 tggaggattt aatcacgtta gttaatgaac ttaacgaacg aggtgtgagt tttcatagtt
     8161 tagaagaaaa tataacgatg gataaatcaa gttctacagg acaattatta tttcatttat
     8221 tcgcagcatt tgcagagttt gaacgtaatt taattttaga gcgatcatca gccggtcgaa
     8281 ttgcagcacg tgctagaggc cgatatggag gtagacctga aaaattaaat aaacaagatt
     8341 taaacttact taagacactt tatgataatg gtacgccaat taaaacaatt gcagagcagt
     8401 ggcaagtttc acgtacaact atttatcgtt atctcaataa attagaggca aaagagaata
     8461 aaaacaagta gagcaactaa tctagcttac tataatgaat ctactaaata attttatata
     8521 tcattaacat acaaagactt tgattcaatg tcactcgatg taaaagagac gttctgacag
     8581 cgtctaaaat ctcataatat tttcctgtta tgagatttta ataataacac aagaaaaaag
     8641 cgtacaaatt cgtacgcttt tttaatataa tacctgtttc actaatgaac gttttaagta
     8701 tcttcatcat taactgaaac tacagtaata atactcgtca acaatattag tatagttaaa
     8761 atagaaagac ttaggactgg cataaccgaa ctaaaattat atttgaaata taaaagtgct
     8821 aatgaagaga gaaatgtaaa aataataaat accaaagacc atttttctaa tttattcatt
     8881 ggcttcacct ctttgaactt ttatataatc ataggagata tttttactac gatttataaa
     8941 aaataagaag ataatcatta ttaaagaaac gattaatata atgttgaatc ctatagtatc
     9001 acctaattcg tttacacctt tgcctaatat cggagataca aagctttgta ttaataatga
     9061 aagagatgcc catatagtaa atgaggttct gttgcaaagt tgaatttata gtataatttt
     9121 aacaaaaagg agtcttctgt atgaactatt tcagatataa acaatttaac aaggatgtta
     9181 tcactgtagc tgttggctac tatctaagat atgcattgag ttatcgtgat atatctgaaa
     9241 tattaaggga acgtggtgta aacgttcatc attcaacggt ctaccgttgg gttcaagaat
     9301 atgccccaat tttatatcaa atttggaaga aaaagcataa aaaagcttat tacaaatggc
     9361 gtattgatga gacgtacatc aaaataaaag gaaaatggag ctatttatat cgtgccattg
     9421 atgcagaggg acatacatta gatatttggt tgcgtaagca acgagataat cattcagcat
     9481 atgcgtttat caaacgtctc attaaacaat ttggtaaacc tcaaaaggta attacagatc
     9541 aggcaccttc aacgaaggta gcaatggtta aagtaattaa agcttttaaa cttaaacctg
     9601 actgccattg tacatcgaaa tatctgaata acctcattga gcaagatcac cgtcatatta
     9661 aagtaagaaa gacaaggtat caaagtatca atacagcaaa gaatacttta aaaggtattg
     9721 agtgtattta cgctctatat aaaaagaacc gcaggtctct tcagatctac ggattttcgc
     9781 catgccacga aattagcatc atgctagcaa gttaagcgaa cactgacatg ataaattagt
     9841 ggttagctat atttttttac tttgcaacag aaccagcatt tgttttaata tttgttccaa
     9901 agagccatca tggctttgac agagctcttc ttctatgcaa atgcttttaa tccgatccac
     9961 acgaaaattc ctatattcat ttcttagcct gcaaaaccga ttaagtacca gttctgttca
    10021 taaaacccca gtgatatagg ctctatcatt ctgctttccg gttcttgccc tcctgatgca
    10081 ggatattgaa ttgatattac ccttttattg cagattgcag tctgaattgc tgcaataacg
    10141 ttatccgcca atgtattttt ctgtccagat gtgctgtaca cgttaatact gttctccaac
    10201 tcctgtgcat agtttttttc accatgcttc aaaatagatt tgattttata catagctgaa
    10261 tcaaaatcct ttataaatga ttcatctcca tggcaattta aaaatttccc tgctgtaatc
    10321 aatgcaccca cttccgccgc tgtaaacatt accggcggaa gtaggaagcc ctctacaaga
    10381 aaatatcctt ttccggcctc agatccaatt ggtattccgg cttcttcaag tgtccggata
    10441 tctctgtaaa ctgtccttaa gcttatatta aatcgctgtg caatttcttt ggcaggaatt
    10501 atttttttga ttgcagctga ataagaatag aggttactct gttaatcctg ttcaaatttt
    10561 attcctcctc tgtgacttcc ataaaaagta tatcctatgc gttcttaagc tagctgctgt
    10621 tagtgcttct cattgcaccc tggttataaa agccatactc acaaacctct tcaccaaaac
    10681 tctttacatc tctaatatag aactctatct agcgaacttt tagaaaagat ataaaacatc
    10741 agagtatgga cagttgcgga tgtacttcag aaaagattag atgtctaaaa agcttgtagt
    10801 taaagctttt tagacatcta aatctaggta ctaaaacaat tcatccagta aaatataata
    10861 ttttattttc tcccaatcag gcttgatccc cagtaagtca aaaaatagct cgacatactg
    10921 ttcttccccg atatcctccc tgatcgaccg gacgcagaag gcaatgtcat accacttgtc
    10981 cgccctgccg cttctcccaa gatcaataaa gccacttact ttgccatctt tcacaaagat
    11041 gttgctgtct cccaggtcgc cgtgggaaaa gacaagttcc tcttcgggct tttccgtctt
    11101 taaaaaatca tacagctcgc gcggatcttt aaatggagtg tcttcttccc agttttcgca
    11161 atccacatcg gccagatcgt tattcagtaa gtaatccaat tcggctaagc ggctgtctaa
    11221 gctattcgta tagggacaat ccgatatgtc gatggagtga aagagcctga tgcactccgc
    11281 atacagctcg ataatctttt cagggctttg ttcatcttca tactcttccg agcaaaggac
    11341 gccatcggcc tcactcatga gcagattgct ccagccatca tgccgttcaa agtgcaggac
    11401 ctttggaaca ggcagctttc cttccagcca tagcatcatg tccttttccc gttccacatc
    11461 ataggtggtc cctttatacc ggctgtccgt catttttaaa tataggtttt cattttctcc
    11521 caccagctta tataccttag caggagacat tccttccgta tcttttacgc agcggtattt
    11581 ttcgatcagt tttttcaatt ccggtgatat tctcatttta gccatttatt atttccttcc
    11641 tcttttctac agtatttaaa gataccccaa gaagctaatt ataacaagac gaactccaat
    11701 tcactgttcc ttgcattcta aaaccttaaa taccagaaaa cagctttttc aaagttggcg
    11761 tataacatag tatcgacgga gccgattttg aaaccacaat tatgatagaa tttacaagct
    11821 ataaggttat tgtcctgggt ttcaagcatt agtccatgca agtttttatg ctttgcccat
    11881 tctatagata tattgataag cgcgctgcct atgccttgcc ccctgaaatc cttacatacg
    11941 gcgatatctt ctatataagc gtaccggttc caattttttc gcagtttaac ttttccgacg
    12001 catttatcgt cttggtagta aagatatatt atcttatcag tattgtcaat atattcaagg
    12061 caatctgcct cctcatcctc ttcatcctct tcgtcttggt agctttttaa atatggcgct
    12121 tcatagagta attctgtaaa ggtccaattc tcgttttcat acctcggtat aatcttaccg
    12181 gttctgttgc aaagtaaaaa atatagctaa tcactaatat atcatgtcag tgttcgttta
    12241 acttgctagc atgatgctaa tttcgtggca tggggaaaat ccgtagatct gaagagacct
    12301 acggttcttt ttatatagag cgtaaataca ttcaatacct tttaaagtat tctttgccgt
    12361 attgatactt tgatatcttg tctttcttac tttaatatga cggtgatctt gctcaatgag
    12421 gttattcaga tatttcgatg tacaatgaca gtcaggttta agtttaaaag ctttaattat
    12481 tttagccatt gctgccttcg ttgaaggtgc ctgatctgta actacctttt gaggcttacc
    12541 aaattgttta atgagacgtt tgataaacgc atatgctgaa tgattatctc gttgcttacg
    12601 caaccaaata tctaatgtat gtccctctgt atcaatggca cgatataaat agctccattt
    12661 tccttttatt ttgatatacg tctcatcaat acgccatttg taataagctt ttttatgctt
    12721 tttcttccaa atttgatata aaattggggc atattcttga acccaacggt agatcgttga
    12781 atgatgaacg tttacaccac gttctcttaa tatttcagat atatcacgat agctcaatgc
    12841 atatcttaga tagtagccaa cggctacagt gataacatcc ttgttaaatt gtttatatct
    12901 gaaatagttc atacagaaga ctcctttttg ttaaaattat attataaatt caactttgca
    12961 acagaacctc ctaactgtat taccacctta aaagtagttg cagacgcact tcctaaatcg
    13021 tcagcagtgt ttaaccacat atcatcaaca ataatcatat gacctgttga tgatactgga
    13081 gcaaattctg tcaacccttc aactacacct aaaataaatg ctttaatctg ctctataaaa
    13141 cccatttttc tcctcctttt aacttatatc agttttttta aagtatgaga ataatataat
    13201 tacactgaat atagatgtaa caattatgat aattaaagat aatagaaatg gataagtatt
    13261 aggtaatgtt cctctagata tgtctccaac tgcagcccaa ggaaataatc ctctatgttc
    13321 agaattagca gtcattaaat ttatcaaagt aattattatg gttaaaacaa ttgtgggaac
    13381 ataattttta aaatatatcg acaaaataat tattggtgga gataatatcc ataataacac
    13441 tccgccaata acaaatgtaa agaatgaatc aattattaaa ctctggctta acccttgaaa
    13501 atgcaatagc atacctagca ttaaagttag caaccatgca ataacagata gtgtttgaat
    13561 ccacaagaat aataatatta ttttacttac taaaaaactt tctctagata taggtataat
    13621 taataagttt tttaaagtat cttctatata ttctcttcca aacaaatagg ctattataac
    13681 cccatataga ggaggtccaa taattagcat atgatataaa ctgacttctt caaataactg
    13741 tttaaataca atattaggag tcggtacttt cgtccgcata ctaataaaag aagctacaac
    13801 caccataaaa ggtgctacgc atgtacctaa aatacttatt agaaacatat atgatctttt
    13861 taacttaata aattctgtac ggagtagatt atccaattgt gccacctcct actaagtctt
    13921 cgaaataagt ttctagatta tcttctatca ctctcatctg gaaaacatca atattgttta
    13981 atactaataa tctattaatt tcttgttgtc tatcaatatg tgaataaatt ttaaattcgc
    14041 cattttcttt aattttatag tcataaattc cgaagttagt ttccaacaaa catgcaactt
    14101 tttcttcatc tgatactgat atacttataa attgtctgtt cttttttttt aaatcttcat
    14161 acataatttc ttctaacaaa actccgttat gaataatacc caccttgtct actaactgct
    14221 ctatttctga caatatatga cttgaaatta aaatggttat atttctagat tgagccagat
    14281 ccttaatcaa ctttctaatt tcttttatgc caataggatc taatccattc gtcggctcat
    14341 caagtatcaa taattcggga ttgtgcaata aagctctcgc aatccctaaa cgttgcttca
    14401 tacctaaaga ataattttta aacaatttta ctttttcaga agctagtcct actatttcta
    14461 acacttcttc aattgcattt tctttttgta tacctaatat tttagcattt atagttaagt
    14521 tctctttagc tgtcaaatta ctataaaaac ctggcgtttc aaccatagca ccaatatttt
    14581 ttaaaatttc agttttatta ctttcgaact ctttttcaaa tattttaata ttacctttcg
    14641 taggtttaat taagcctaaa agcattctta tagtagttgt tttgcctgca ccatttcttc
    14701 ctaaaaaacc ataaatttgt ccactttcaa cagttatact caaattatta actgctatct
    14761 gacttccata ttgctttgtt aagttattta tttcaattat attattcaaa tttttcacct
    14821 ctggcacctt tcttagtttg ttgttacctt tatcttacgc gcgattagaa aaggctgcct
    14881 ttatctattc ttacaaaaac agccgctaat cttacaaaaa tgaaagattg gagttattta
    14941 aattgaatgg tgaatattga accatcgttt aatgtagatg tagcacttac tttatggcct
    15001 aagcgctttg agattgtgct gacaatatat aaaccaatac cgcttgattt ctcacttatt
    15061 ctaccgttat agcccgagaa acctttatca aagattttcg gtaaatcact cgcattaatg
    15121 ccgataccgt tatctcggat tgataatttc tttgtatttt cgtcaaacgt aatccacaca
    15181 tctttgccac gtgcatattt taatgcattg tttaatattt gctcaatcat aattgatgcc
    15241 catttggcat ctgttaatat aaccgcttca cttttctcat aatgcaactt tgtttgatga
    15301 tgaataaact gtatcgcata acgtttaatc agtggtcgaa ttaattcatc tacactcact
    15361 tccataaaga ccatgtatgt cttttggttc atgagtttca aatagttcag tgcaagattc
    15421 gtgtaattat caatttgtaa gacttcatta cgcacgttag aaatcacgtg ttcatcagga
    15481 tcttcaagca gtaactttga tgctgtaatc ggtgtcttga tttgatgcac ccacattaaa
    15541 aaatatgact ctaactcact ttggtagtta ataaagtcat tacgaagttt atggttttcg
    15601 attcttaaat cttcgttctg ttcctgtagt gtttattctt ttttaaagtt catgtaatgg
    15661 ataccccagt aaatcattga aacaaacaat acaataccta gaccaatcat atatgcttgc
    15721 atcggcacat tatacatgaa taatataaag tagaataaag cacaagtaag gatgacaata
    15781 taaatttcac gttggattga tttcaagaaa ttcatacgtc acctacacga tatccgacat
    15841 ttttcttcgt ttcgataaaa tctgtaagtc ctagtttttg tagctttttg cgtaaacgtg
    15901 taatgttgac agcaagcgta ttgtcatcaa tgaagtgttc tgattcccag catttttcga
    15961 ttaacgcatt acgactgacg aatttgccct tgttctggaa taagctatgc atgatttgca
    16021 attcagtgtg tgtcaggtct atggtttctt cattaaattt aagctttgct gcatcaagta
    16081 gtaactcgca atcatctact gttaaattat taacttgagt ggtgaaatca tacgtgcggc
    16141 gtaatagtgc ttgaatctta gtaattgtaa cagtcatatt aaatggctgg ttctgttgca
    16201 aagtaaaaaa tatagctaat cactaatata tcatgtcagt gttcgtttaa cttgctagca
    16261 tgatgctaat ttcgtggcat ggggaaaatc cgtagatctg aagagaccta cggttctttt
    16321 tatatagagc gtaaatacat tcaatacctt ttaaagtatt ctttgccgta ttgatacttt
    16381 gatatcttgt ctttcttact ttaatatgac ggtgatcttg ctcaatgagg ttattcagat
    16441 atttcgatgt acaatgacag tcaggtttaa gtttaaaagc tttaattatt ttagccattg
    16501 ctgccttcgt tgaaggtgcc tgatctgtaa ctaccttttg aggcttacca aattgtttaa
    16561 tgagacgttt gataaacgca tatgctgaat gattatctcg ttgcttacgc aaccaaatat
    16621 ctaatgtatg tccctctgta tcaatggcac gatataaata gctccatttt ccttttattt
    16681 tgatatacgt ctcatcaata cgccatttgt aataagcttt tttatgcttt ttcttccaaa
    16741 tttgatataa aattggggca tattcttgaa cccaacggta gatcgttgaa tgatgaacgt
    16801 ttacaccacg ttctcttaat atttcagata tatcacgata gctcaatgca tatcttagat
    16861 agtagccaac ggctacagtg ataacatcct tgttaaattg tttatatctg aaatagttca
    16921 tacagaagac tcctttttgt taaaattata ttataaattc aactttgcaa cagaaccgta
    16981 ttttatgagt acactctaaa ttaaggagat gtataatcaa tctaaaattg tatttttata
    17041 cttttgttat ataatctttc tacttagaga tatattgtaa aaaaaccaac aaaatgttat
    17101 attaacatta ctattttatc gatgaaggag gattaaaatg acagcttcta tgagactcaa
    17161 ataaaccttt ttgaatacaa aactaaatta attcaaaaag gcttgtccgc aatacacact
    17221 cataggatga cttatgtcat tttttatcct tcgataggaa taataaacgc tttcaaatac
    17281 taaaacatca taataaattt ttaagtgttt gaaagtgtaa tgtgaatgag acgggagtag
    17341 cctgtctcat ttttttgcgt acacgtcctt taaatataca aggagtgtat aaatatggaa
    17401 caatatacaa ttaaatttaa ccaaatcaat cataaattga cagatttacg atcacttaac
    17461 atcggtcatc tttacgctta ccaatttgaa aaaatagcac ttattggggg taatggtact
    17521 ggcaaaacca cattactaaa tatgattgct caaaaaacaa aaccagaatc tggaacagtt
    17581 gaaacggttg gcgaaattca atattttgaa cagcttaaca tggatgtgga aaatgatttt
    17641 aacacgttag acggtagttt aatgagtgaa ctccatatac ctatgcatac aaccgacagt
    17701 atgagtggtg gtgaaaaagc aaaatataaa ttagctaatg tcatatcaaa ttatagtccg
    17761 atattacttt tagatgaacc tacaaatcac ttggataaaa ttggtaaaga ttatctgaaa
    17821 aatattttaa aatattacta tggtacttta attatagtaa gtcatgatag agcacttata
    17881 gaccaaattg ctgacacaat ttgggatata caagaagatg gcacaataag agtgtttaaa
    17941 ggtaattaca cacagtatca aaatcaatat gaacaagaac agttagaaca acaacgtcaa
    18001 tatgaacagt atataagtga aaaacaaaga ttgtcccaag ccagtaaagc taaacgaaat
    18061 caagcgcaac aaatggcaca agcatcatca aaacaaaaaa acaaaagtat agcaccagat
    18121 cgtttaagtg catcaaaaca aaaaggcacg gttgagaagg ctgctcaaaa acaagctaag
    18181 catattgaaa aaagaatgga acatttggaa gaagttgaaa aaccacaaag ttatcatgaa
    18241 ttcaatttcc cacaaaataa aatttatgat atccataata attatccaat cattgcacaa
    18301 aatctaacat tggttaaagg aagtcaaaaa ctgctaacac aagtacgatt ccaaatacca
    18361 tatggcaaaa atatagcgct cgtaggtgca aatggtgtag gtaagacaac tttacttgaa
    18421 gctatttacc accaaataga gggaattgat tgttctccta aagtgcaaat ggcatactat
    18481 cgtcaacttg cttatgaaga catgcgtgac gtttcattat tgcaatattt aatggatgaa
    18541 acggattcat cagaatcatt cagtagagct attttaaata acttgggttt aaatgaagca
    18601 cttgatcgtt cttgtaatgt tttgagtggt ggggaaagaa cgaaattatc gttagcagta
    18661 ttattttcaa cgaaagcgaa tatgttaatt ttggatgaac caactaattt tttagatatt
    18721 aaaacattag aagcattaga aatgtttatg aataaatatc ctggaatcat tttgtttaca
    18781 tcacatgata caaggtttgt taaacatgta tcagataaaa aatgggaatt aacaggacaa
    18841 tctcttcatg atataactta aaaactatac actaatttat attgaatatt aggttcattt
    18901 atatcaatat aaaaaatacg ttcacaagaa aaatataata gaaataagga tccaataaaa
    18961 tgactcgaca taatgaaatt attaaatgtg cagaaaaata tcaattacac atccaacctc
    19021 aaacaatctc attgaatgaa tcgggacttg attttcaagt tgcatttgga aaagataaac
    19081 atggagtaga atgggttttg agactaccaa gaagacctga cgtttataaa cgaacaaaac
    19141 ccgaaaaaca aacggtagac ttcttacaga agaatgtttc atttgaaata ccgaagtgga
    19201 aagtacatgc aaaagacctt attgcttacc caaaacttac aggtaaaccc gcagccacaa
    19261 tagatccaga aatacaaaat tatgtatggg aaattgaaca caaaccatta ccagaaaact
    19321 ttattaacac attagctgaa acactcgtag atttacacaa cataccagaa gaaaacatta
    19381 acgttcagca tataaatatc aaaaccatac aagaaataaa aaatgacttt caaagaagaa
    19441 tgaataaagt taaagaaact tatggcgtat cagatgaatt atggaacaga tggaaacaat
    19501 ggttagaaaa cgacgaacta tggcctcgac atgcgaccat gatacatggg gacttacatc
    19561 caggacatat aatggtagat aaccaagcaa acgtcacagg tctcatagac tggactgaag
    19621 caacccactc cgacccatca atggacttta taggacacca tcgtgtattc gacgacgaag
    19681 gattagagca acttataaca gcatacggta aagctggagg tgaaatatgg ccacgaatga
    19741 aagagcatat aatagaactc aatgcagtat tcccaatgtt tatcgctgag tttgctatgg
    19801 aatcaggaga atcggcgtat gaaacgatgg cattgaaaga gttaggtatg aaagagtaga
    19861 acttatatta aaagaggccc attttaaaga cgaaggcaat cctgatgaaa ttttaaaact
    19921 gcgtttaatt agtgatggtc tttggttttc tataatgtat taaatatctg gacatggaac
    19981 aaatgcaaca aatggaaaga atcgttttcg aaatttctaa ctccttaaat caggaggata
    20041 aataaacggt cattttcatt gaaagcactt atataaattt catcaatttt aatacctacc
    20101 gtaaatacat ttcataagta ttaaacagat gattaaaatt tttagttaat ttaaatattt
    20161 atgatagaga tgaccttcaa atgaacgttt ataacgcaat catgatgaga gtattaatac
    20221 agttaattat ttgaaatact ttagtttaca taatcgatga ttaccagaag ttctcactat
    20281 ataaaagaca ctaaaatttt ataactttta gtgcctaatc aattatttta gctaccaaac
    20341 aaacgactcc aaaacccctt tttaggttcc gtttcttcac tcttttcttc tatatcacta
    20401 tcattgtcat ttagattagc tggaacgtct tctttttttg cttcttcacc ttgtgtactt
    20461 tcgtcgcttt gacttccaga tatatcctta tattgaatct ctgtttcttt agtttcttcc
    20521 tgatctctgt taatatttac aggattagta gtatatgttt tttcttgtgc atcaacgttt
    20581 tgtctagtgt tagtagatgt atcaaaggga taattaaggt gtttttcttt ttctaattga
    20641 ttttctaatt tttgaatctt tttattactc tctaatgcca gaacttgctg attttcaagc
    20701 aattttgatc tttcttgcaa ctcttttctg taaaattcaa ttgttgtttc atgacgactt
    20761 tcttgttttt caatttgatt atttaaagta tcaatctgat ttttaaggat ttctactatt
    20821 tgagcatcgc ttttcgattc aaaattaata ttatccgacc cttttttttg tttgtcttca
    20881 gtagtacttt caaaaccata tttcttttta ttttcattta ctctttgaat gattttttct
    20941 atatcggtat cttctttaat aaacgaagtg ttttcctgtt ttattgtctc tatattcaat
    21001 cgcttaatat tattaaaaat cgtttgctta ctaaccccta attcttcact caactttttc
    21061 acacttttca tatcatcaac cctttataaa atgtttataa acccttgata aaatattata
    21121 atcttataat gcttaataat aaagtgatta ataaataaaa ataaacatcc atcaaccttt
    21181 ttatcaaggg tttatgaaag gtttatgata tttatcaagg gtttataaac ccttgataaa
    21241 gctatatttt cccttttata agtttattta aagtgctata ataaacttaa tataacaaaa
    21301 accccaacta ctggtaatag tcggggtttg gtaataaaac gtttagaaac tgtttattta
    21361 tataattttc gatacttgta ttatataatg aataatatct tagtgcaagc acctaaatca
    21421 ttaaataaat gtaaagctaa ataaaaacgt tttattacct cttaccaaac taaaatatgg
    21481 aaagaggttt tttgtcatgc aaaatcaata ttttacagtg caagaaaatt acaaagaaag
    21541 attttatcaa atccctaaag tattctttac cagtgaaaat tataaaaatc taactaatga
    21601 tatgaaaata gcctatgcta tcttacgtga tcgcttaaat ttatctatta aaaatagctg
    21661 ggttgatgaa gatggtaaca tttactttgt ttattcaaat gaaaagctaa tggaaatctt
    21721 aaattgtaaa aaagaaaagt taacaaaaat aaaaaaaggg ttagaaaacg atggtctact
    21781 cattcaaaaa cgacgtggtt taaataaacc aaatattcta tatttaatga aacctattgt
    21841 cacagaacgt gatatttaca aaatagaaaa agaagaaaac gatgttgaac cttacggcga
    21901 gaaggaagtt cgaaaatcga acgtccagaa gttcgaaaat cgaacgtcca gaagttcgaa
    21961 aatcgaacgt ccagaagttc gaaaatcgaa cactaatgat actgacttta atgacattga
    22021 ctttaatgat actgagaata atgatatgaa tgacttgaat gatataaagt acaaaaatga
    22081 aattagtaat cattcaaatc attcaaatca atttacacat aattttgatg ataaagaaat
    22141 gctattgcaa gaattcccag aacaactaac taattattta ttaaaatatg attatagaga
    22201 tttagaaatc ataaaggctg ttattcttaa agcaaaaaaa tcatttaatt caaggcatga
    22261 agatatgcat tacatgttag aggacattga ggatgaaata ttaacttctt taaaaagact
    22321 taaaaaagct atacatgata ggggagttaa aggccaaaag gaaacaatca agtcaatgca
    22381 agcttattta atgcaaacaa ttctaactga acttgaagaa acacatgccc tttatatgcg
    22441 ccgtaaaaac atgaaacaat ataatatctt taatcaataa ttcaaatgat tttataacac
    22501 tcgaagagac atcaaaatat tccgttaaat catctgactt tttaactgat gacgacgaaa
    22561 aaaatcaaga aattgtaagt gatttagaaa aaggtttgta tcgaaaacgt atgttaagtt
    22621 atggtggatt gcttaaacaa aagcataaaa ttttaaactt agacgatgcc gaagatggta
    22681 atttgattaa tacaagtgat gaagataaaa cgacagacga agaaaaaaag cacattcaat
    22741 taccgcaatt tggaatttcg aaaagcaaaa ttattattta agacattagt gataactgat
    22801 gtcttttttt attgtttttc tgtaaaaaag tgctgtctta tttttgtgac aaatgctgta
    22861 tgtagtgtca caaaagtgtg acactacagc tttgtatgat atcactttaa aataacttaa
    22921 aacccttgga atgtctggcc ttgccagatc tatcattttt gaatgatagc aaatttccct
    22981 tatgctctta cggagatttt agagttaaat taaaatttct aagtttttga taagaaaagc
    23041 cctgcaggaa tttagaaaaa catggggaag ttttaaagta ttttatgcta atttttaaat
    23101 ttgcatgtaa atgggcagta tctaaaaaat tagtcactga ttttgctgaa atttttgttt
    23161 gtgaaattag catatattta tttggctcat atttgcgttt taagagactg tatagatttt
    23221 taagtacaaa acctatatga tttgcctcta agtcttcaaa atgcctctta aaatccaaaa
    23281 taaaagtgtt taatattgta ataaggattg ctatttttat aaaaggagag atatcatgaa
    23341 gattaaaact ttcgctactt ttactcatcg tcaattagat aaacaagtta ataggttttt
    23401 aaagaatgat attcatgtat tagaaattca aacacacagt aattggttat atatttcagc
    23461 tattgttttt tatgaggata aataaggaac atcgtattta tgccgaaaaa atttattgat
    23521 gttgagaaga acccttaact aaacttgcag acgaatgtcg gcatagcgtg agctattaag
    23581 ccgaccattc gacaagtttt gggattgtta agggttccga ggctcaacgt caataaaaca
    23641 attggaataa aatcaaccta cagagcatcc agctgcaaat gcagttccgc aaactgcttc
    23701 acatacaccg ccggctattg gatttacgat tgcccatact ccacagtagt gagcacatgc
    23761 ataaagtcca gccatactac aagcgaatgc tttgccgttc catttgaatc ctgcatatgt
    23821 taccggtctg tttttatcaa ctttttcagc cttatattca acgtaatttt tgttaataag
    23881 tatttttccc tctttgtttt cagtcatact tcttttttcg gcaatgaatt ttgtgatttt
    23941 tttgttgtag ttatcatata ttgtttcaga aactacaatt tcttttgttt tttcattttt
    24001 ataagcgtta ttagctatgt agccatatgc atttttatca tttgcttctg tagctagata
    24061 ttttaattta gaatttttgt cttctagctt tattttttta aatccttctt ttttcatttg
    24121 cttttcgaat ttttgcatat cttcattttt attttgcaat tgttctagaa aacttatttc
    24181 tttcttggtc atttgtgata cttcgatgtt tttgcttttc aatttttctt tttgattttc
    24241 tagtaaagaa cttttttgtt cttcatttgc gtaagcatta gaaaaattcg cgctaaatac
    24301 cagtaggaac aaggaaatta ttgaaaataa ttttataatt ttcatttgat acctccaaga
    24361 taataagata ttttaattgt ataagtaagc gctttataaa atcaatattt attttaatat
    24421 atttataaac atatttttga aaggagtcta ttttatgaat gaaaatttag aaaaatatat
    24481 aaaaagtttg ccacttttag gtttgttaat tagtattttg ttaattgttt tattcttttt
    24541 tattttagat gttgatgaag atttattcgt ggttttttta tactgtttat tgcctttgat
    24601 agttaatttg tctatttatg gtttttatgt ttttgttaaa agaaagt
//
