LOCUS       CP051897               25434 bp    DNA     circular BCT 24-SEP-2020
DEFINITION  Staphylococcus aureus strain ER11761.3 plasmid pER11761.3A.1,
            complete sequence.
ACCESSION   CP051897
VERSION     CP051897.1
DBLINK      BioProject: PRJNA470993
            BioSample: SAMN14669448
KEYWORDS    .
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 25434)
  AUTHORS   Caban,A.B., Pak,T., Kumaresh,A., Dupper,A., Chacko,K.,
            Sullivan,M.J., Altman,D.R. and van Bakel,H.
  TITLE     PathoSPOT genomic surveillance reveals prolonged under the radar
            outbreaks of nosocomial methicillin resistant S. aureus bloodstream
            infections
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 25434)
  AUTHORS   Caban,A.B., Pak,T., Kumaresh,A., Dupper,A., Chacko,K.,
            Sullivan,M.J., Altman,D.R. and van Bakel,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2020) Genetics and Genomic Sciences, Icahn School
            of Medicine, One Gustave L. Levy Place Box 1498, New York, NY 10029,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 404.169902061856x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 04/23/2020 10:04:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 2,956
            CDSs (total)                      :: 2,876
            Genes (coding)                    :: 2,791
            CDSs (with protein)               :: 2,791
            Genes (RNA)                       :: 80
            rRNAs                             :: 6, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 85
            CDSs (without protein)            :: 85
            Pseudo Genes (ambiguous residues) :: 0 of 85
            Pseudo Genes (frameshifted)       :: 48 of 85
            Pseudo Genes (incomplete)         :: 28 of 85
            Pseudo Genes (internal stop)      :: 21 of 85
            Pseudo Genes (multiple problems)  :: 12 of 85
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..25434
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="ER11761.3"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pER11761.3A.1"
                     /geo_loc_name="USA:New York City"
                     /lat_lon="40.7903114 N 73.9528738 W"
                     /collection_date="2017"
                     /collected_by="Mount Sinai Hospital"
     gene            join(24762..25434,1..2)
                     /locus_tag="HIL08_00005"
     CDS             join(24762..25434,1..2)
                     /locus_tag="HIL08_00005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="QOA28495.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            143..778
                     /locus_tag="HIL08_00010"
                     /pseudo=""
     CDS             143..778
                     /locus_tag="HIL08_00010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032491779.1"
                     /note="internal stop; incomplete; partial on complete
                     genome; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside 6-adenylyltransferase"
                     /name="aminoglycoside 6-adenylyltransferase"
     gene            775..1305
                     /gene="sat4"
                     /locus_tag="HIL08_00015"
     ARG             776..1302
                     /name="sat4"
                     /gene="sat4"
                     /gene_name="streptothricin N-acetyltransferase Sat4"
                     /tool="amrfinderplus"
                     /drug_class="STREPTOTHRICIN"
                     /identity="97.78"
                     /coverage="100.0"
     gene            1398..2192
                     /gene="aph(3')-IIIa"
                     /locus_tag="HIL08_00020"
     ARG             1399..2189
                     /name="aph(3')-IIIa"
                     /gene="aph(3')-IIIa"
                     /gene_name="aminoglycoside O-phosphotransferase
                     APH(3')-IIIa"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(2300..2488)
                     /locus_tag="HIL08_00025"
                     /pseudo=""
     CDS             complement(2300..2488)
                     /locus_tag="HIL08_00025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002913594.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            2468..3039
                     /locus_tag="HIL08_00030"
                     /pseudo=""
     CDS             2468..3039
                     /locus_tag="HIL08_00030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001079940.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="HTH domain-containing protein"
                     /name="HTH domain-containing protein"
     gene            complement(3208..3882)
                     /locus_tag="HIL08_00035"
     CDS             complement(3208..3882)
                     /locus_tag="HIL08_00035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="QOA28474.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            4144..4329
                     /locus_tag="HIL08_00040"
     CDS             4144..4329
                     /locus_tag="HIL08_00040"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOA28475.1"
                     /translation="MNKLEKWSLVFIIFTFLSSLALLYFKYNFSSVMPVLSLSILTILI
                     LLTSIITVVSVNDEDT"
                     /name="hypothetical protein"
     gene            complement(4552..5130)
                     /locus_tag="HIL08_00045"
     CDS             complement(4552..5130)
                     /locus_tag="HIL08_00045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="QOA28476.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNKQDLNLLKTLYDNGTPI
                     KTIAEQWQVSRTTIYRYLNKLEAKENKNK"
                     /name="recombinase family protein"
     gene            complement(5394..5774)
                     /gene="blaI"
                     /locus_tag="HIL08_00050"
     ARG             complement(5398..5774)
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.21"
                     /coverage="100.0"
     gene            complement(5764..7521)
                     /gene="blaR1"
                     /locus_tag="HIL08_00055"
     ARG             complement(5768..7521)
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="98.8"
                     /coverage="100.0"
     gene            7628..8473
                     /gene="blaZ"
                     /locus_tag="HIL08_00060"
     ARG             7629..8470
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.29"
                     /coverage="100.0"
     gene            complement(8987..9406)
                     /locus_tag="HIL08_00065"
     CDS             complement(8987..9406)
                     /locus_tag="HIL08_00065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418035.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="QOA28480.1"
                     /translation="MELDNCINYLLSTSQNRVFKHFKSLLSPYNITPAEYGVLNCLINS
                     NLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRTVLINSTNKAKDLWPTL
                     EKKAYQLNNHYFANLTNEETVVFKKILLKINKTTF"
                     /name="MarR family transcriptional regulator"
     gene            9530..10501
                     /locus_tag="HIL08_00070"
     CDS             9530..10501
                     /locus_tag="HIL08_00070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="QOA28481.1"
                     /translation="MFNAVVVRKSASNVSYKVEKVDESHLSKGDVLVKVVYSSINYKDM
                     LALQYKGGVIRDYPMIPGIDFAGIVESSSNDKFKEGDNVLVTGYDVGVTHTGGFSEYAQ
                     VPGEWIVPIPQEMSIKESMVYGTAGFTAALSIFELEKYGMNIKSQPEILVSGATGGVGS
                     VAIQILHKIGYENITAIVRKEKQIEIAKKLGAKQVIIIEDDNKPLKKGIFDYFLDTVGS
                     NVTLYGLKRLNYQGVATVCGNVAGNSLNANILPFILRGIKLIGIDSVYVDHNIREDIWS
                     KLANEWNIGNSLLYNEIGFEEFYKTIDQLLKGQHLGRTILKV"
                     /name="oxidoreductase"
     gene            complement(10673..10765)
                     /locus_tag="HIL08_00075"
     CDS             complement(10673..10765)
                     /locus_tag="HIL08_00075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="QOA28482.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(10922..11269)
                     /locus_tag="HIL08_00080"
     CDS             complement(10922..11269)
                     /locus_tag="HIL08_00080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="QOA28483.1"
                     /translation="MSYENTCDVICVHEDKVNNALRFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNHEGF"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(11288..11905)
                     /gene="cadD"
                     /locus_tag="HIL08_00085"
     ARG             complement(11292..11905)
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(13026..13220)
                     /locus_tag="HIL08_00090"
     CDS             complement(13026..13220)
                     /locus_tag="HIL08_00090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001004925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOA28485.1"
                     /translation="MNENLEKYIKSLPLLGLLISILLIVLFFFILDVDEDLFVVFLYCL
                     LPLIVNLSIYGFYVFVKRK"
                     /name="hypothetical protein"
     gene            13330..14022
                     /locus_tag="HIL08_00095"
     CDS             13330..14022
                     /locus_tag="HIL08_00095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOA28486.1"
                     /translation="MKIIKLFSIISLFLLVFSANFSNAYANEEQKSSLLENQKEKLKSK
                     NIEVSQMTKKEISFLEQLQNKNEDMQKFEKQMKKEGFKKIKLEDKNSKLKYLATEANDK
                     NAYGYIANNAYKNEKTKEIVVSETIYDNYNKKITKFIAEKRSMTENKEGKILINKNYVE
                     YKAEKVDKNRPVTYAGFKWNGKAFACSMAGLYACAHYCGVWAIVNPIAGGVCEAVCGTA
                     FAAGCSVG"
                     /name="hypothetical protein"
     gene            complement(14190..14339)
                     /locus_tag="HIL08_00100"
     CDS             complement(14190..14339)
                     /locus_tag="HIL08_00100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000695367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOA28487.1"
                     /translation="MKIKTFATFTHRQLDKQVNRFLKNDIHVLEIQTHSNWLYISAIVF
                     YEDK"
                     /name="hypothetical protein"
     gene            complement(14886..15202)
                     /locus_tag="HIL08_00105"
                     /pseudo=""
     CDS             complement(14886..15202)
                     /locus_tag="HIL08_00105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002483623.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            complement(15195..16178)
                     /locus_tag="HIL08_00110"
     CDS             complement(15195..16178)
                     /locus_tag="HIL08_00110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="QOA28488.1"
                     /translation="MQNQYFTVQENYKERFYQIPKVFFTSENYKNLTNDMKIAYAILRD
                     RLNLSIKNSWVDEDGNIYFVYSNEKLMEILNCKKEKLTKIKKGLENDGLLIQKRRGLNK
                     PNILYLMKPIVTERDIYKIEKEENDVEPYGEKEVRKSNVQKFENRTSRSSKIERPEVRK
                     SNTNDTDFNDIDFNDTENNDMNDLNDIKYKNEISNHSNHSNQFTHNFDDKEMLLQEFPE
                     QLTNYLLKYDYRDLEIIKAVILKAKKSFNSRHEDMHYMLEDIEDEILTSLKRLKKAIHD
                     RGVKGQKETIKSMQAYLMQTILTELEETHALYMRRKNMKQYNIFNQ"
                     /name="replication initiator protein A"
     gene            16604..17347
                     /locus_tag="HIL08_00115"
     CDS             16604..17347
                     /locus_tag="HIL08_00115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002508633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="QOA28489.1"
                     /translation="MKSVKKLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESTTEDKQKKGSDNINFESKSDAQIVEILKNQIDTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNTR
                     QNVDAQEKTYTTNPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAKKEDVPANLND
                     NDSDIEEKSEETEPKKGFWSRLFGS"
                     /name="DUF536 domain-containing protein"
     gene            complement(17816..18715)
                     /gene="mph(C)"
                     /locus_tag="HIL08_00120"
     ARG             complement(17820..18715)
                     /name="mph(C)"
                     /gene="mph(C)"
                     /gene_name="Mph(C) family macrolide 2'-phosphotransferase"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(18814..20280)
                     /gene="msr(A)"
                     /locus_tag="HIL08_00125"
     ARG             complement(18818..20280)
                     /name="msr(A)"
                     /gene="msr(A)"
                     /gene_name="ABC-F type ribosomal protection protein Msr(A)"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE/STREPTOGRAMIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            20754..21428
                     /locus_tag="HIL08_00130"
     CDS             20754..21428
                     /locus_tag="HIL08_00130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="QOA28492.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            21486..21863
                     /locus_tag="HIL08_00135"
                     /pseudo=""
     CDS             21486..21863
                     /locus_tag="HIL08_00135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000866106.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /name="response regulator transcription factor"
     gene            21860..22741
                     /locus_tag="HIL08_00140"
                     /pseudo=""
     CDS             21860..22741
                     /locus_tag="HIL08_00140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_501406.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /name="HAMP domain-containing histidine kinase"
     gene            22857..23785
                     /locus_tag="HIL08_00145"
                     /pseudo=""
     CDS             22857..23785
                     /locus_tag="HIL08_00145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000074567.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /name="ABC transporter ATP-binding protein"
     gene            23778..24515
                     /locus_tag="HIL08_00150"
     CDS             23778..24515
                     /locus_tag="HIL08_00150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000369394.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="QOA28493.1"
                     /translation="MDNLLRTEFIKLKRSYMFLISILGTCVAPFMVVVASFISMRTKVP
                     TPNIVFKQLFEEVSLYHMLIIGPPLYGVIIAYLFGREYIEDTLKNLLIIPISRESFLVS
                     KIILLFLWIQTLSVIAWLLTLMLGMLLHFQGLSQSLIIDSFFTFVIGGVLLWILSPPII
                     ILSIYFKNYVPTIVLTIIITLINLMTANSEHRGLFPWAAVGDISRGTLPNTYPFLLSLI
                     IIIVTSIFSVIILFSYFKKTDIS"
                     /name="ABC transporter permease"
     gene            24529..24732
                     /locus_tag="HIL08_00155"
     CDS             24529..24732
                     /locus_tag="HIL08_00155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001627151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP kinase"
                     /protein_id="QOA28494.1"
                     /translation="MGFIEQIKAFILGVVEGLTEFAPVSSTGHMIIVDDMWLNTADDLG
                     SASATTFKVVIQLGGSVAKLNL"
                     /name="UDP kinase"
     ARG             complement(18815..20280)
                     /name="msrA"
                     /gene="msrA"
                     /gene_name="msr-type ABC-F protein"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; streptogramin
                     antibiotic; streptogramin B antibiotic"
                     /identity="98.36"
                     /coverage="100.0"
     ARG             complement(17817..18715)
                     /name="mphC"
                     /gene="mphC"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="98.66"
                     /coverage="100.0"
     ARG             788..1305
                     /name="SAT-4"
                     /gene="SAT-4"
                     /gene_name="streptothricin acetyltransferase (SAT)"
                     /tool="rgi"
                     /drug_class="nucleoside antibiotic"
                     /identity="97.16"
                     /coverage="95.56"
     ARG             180..481
                     /name="aad(6)"
                     /gene="aad(6)"
                     /gene_name="ANT(6)"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="99.0"
                     /coverage="36.23"
     ARG             7629..8473
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="95.37"
                     /coverage="100.0"
     Typing          complement(14683..14830)
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="5.980000000000001e-72"
     Typing          complement(14889..15064)
                     /name="rep_cluster_1017"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="92.697"
                     /coverage="94.0"
                     /evalue="1.04e-65"
     Typing          complement(15196..16178)
                     /name="rep_cluster_2100"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.593"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          16605..17347
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 aaacgaacac tgacatgata tattagtgat tagctatatt ttttactttg caacagaacc
       61 atcattttta ttaaaatact cttttgtaaa atctttctgc tcttcaatgt atttaatttc
      121 tttacctcta aatctattat agctatttga tgattacaat aaaattgatc ttaccttatt
      181 gcccttggaa gagttagata attacctaaa gggcgataaa ttaataaagg ttctaattga
      241 taaagattgt agaattaaaa gggacatagt tccgactgat atagattatc atgtaagaaa
      301 gccaagcgca agggagtatg atgattgctg caatgaattt tggaatgtaa caccttatgt
      361 tattaaagga ttgtgccgta aggaaatttt atttgctatt gatcatttta atcagattgt
      421 tcgccatgag ctgctgagaa tgatatcatg gaaggtcggc atcgaaacag gctttaaatg
      481 aagtgtaggc aagaactata agtttattga aaggtatata tccgaggatt tgtgggagaa
      541 acttttgtcc acctaccgga tggattccta tgaaaacata tgggaagcat tatttctatg
      601 ccatcaattg ttcagggcgg tatccggtga ggtggcggaa aggcttcatt atgcctatcc
      661 ggagtatgat aggaatataa caaaatatac cagggacatg tataaaaaat acactggtaa
      721 aaccggctgc ctggatagca catatgccgc tgatatagaa gagaggcggg aacagtgatt
      781 acagaaatga aagcagggca cctgaaagat atcgataaac ccagcgaacc atttgaggtg
      841 ataggtaaga ttataccgag gtatgaaaac gagaattgga cctttacaga attactctat
      901 gaagcgccat atttaaaaag ctaccaagac gaagaggatg aagaggatga ggaggcagat
      961 tgccttgaat atattgacaa tactgataag ataatatatc tttactacca agacgataaa
     1021 tgcgtcggaa aagttaaact gcgaaaaaat tggaaccggt acgcttatat agaagatatc
     1081 gccgtatgta aggatttcag ggggcaaggc ataggcagcg cgcttatcaa tatatctata
     1141 gaatgggcaa agcataaaaa cttgcatgga ctaatgcttg aaacccagga caataacctt
     1201 atagcttgta aattctatca taattgtggt ttcaaaatcg gctccgtcga tactatgtta
     1261 tacgccaact ttgaaaaagc tgttttctgg tatttaaggt tttagaatgc aaggaacagt
     1321 gaattggagt tcgtcttgtt ataattagct tcttggggta tctttaaata ctgtagaaaa
     1381 gaggaaggaa ataataaatg gctaaaatga gaatatcacc ggaattgaaa aaactgatcg
     1441 aaaaataccg ctgcgtaaaa gatacggaag gaatgtctcc tgctaaggta tataagctgg
     1501 tgggagaaaa tgaaaaccta tatttaaaaa tgacggacag ccggtataaa gggaccacct
     1561 atgatgtgga acgggaaaag gacatgatgc tatggctgga aggaaagctg cctgttccaa
     1621 aggtcctgca ctttgaacgg catgatggct ggagcaatct gctcatgagt gaggccgatg
     1681 gcgtcctttg ctcggaagag tatgaagatg aacaaagccc tgaaaagatt atcgagctgt
     1741 atgcggagtg catcaggctc tttcactcca tcgacatatc ggattgtccc tatacgaata
     1801 gcttagacag ccgcttagcc gaattggatt acttactgaa taacgatctg gccgatgtgg
     1861 attgcgaaaa ctgggaagaa gacactccat ttaaagatcc gcgcgagctg tatgattttt
     1921 taaagacgga aaagcccgaa gaggaacttg tcttttccca cggcgacctg ggagacagca
     1981 acatctttgt gaaagatggc aaagtaagtg gctttattga tcttgggaga agcggcaggg
     2041 cggacaagtg gtatgacatt gccttctgcg tccggtcgat cagggaggat atcggggaag
     2101 aacagtatgt cgagctattt tttgacttac tggggatcaa gcctgattgg gagaaaataa
     2161 aatattatat tttactggat gaattgtttt agtacctaga tttagatgtc taaaaagctt
     2221 taactacaag ctttttagac atctaatctt ttctgaagta catccgcaac tgtccatact
     2281 ctgatgtttt atatcttttc taaaagttcg ctagatagag ttctatatta gagatgtaaa
     2341 gagttttggt gaagaggttt gtgagtatgg cttttataac cagggtgcaa tgagaagcac
     2401 taacagcagc tagcttaaga acgcatagga tatacttttt atggaagtca cagaggagga
     2461 ataaaatttg aacaggatta acagagtaac ctctattctt attcagctgc aatcaaaaaa
     2521 ataattcctg ccaaagaaat tgcacagcga tttaatataa gcttaaggac agtttacaga
     2581 gatatccgga cacttgaaga agccggaata ccaattggat ctgaggccgg aaaaggatat
     2641 tttcttgtag agggcttcct acttccgccg gtaatgttta cagcggcgga agtgggtgca
     2701 ttgattacag cagggaaatt tttaaattgc catggagatg aatcatttat aaaggatttt
     2761 gattcagcta tgtataaaat caaatctatt ttgaagcatg gtgaaaaaaa ctatgcacag
     2821 gagttggaga acagtattaa cgtgtacagc acatctggac agaaaaatac attggcggat
     2881 aacgttattg cagcaattca gactgcaatc tgcaataaaa gggtaatatc aattcaatat
     2941 cctgcatcag gagggcaaga accggaaagc agaatgatag agcctatatc actggggttt
     3001 tatgaacaga actggtactt aatcggtttt gcaggctaag aaatgaatat aggaattttc
     3061 gtgtggatcg gattaaaagc atttgcatag aagaagagct ctgtcaaagc catgatggct
     3121 ctttggaaca aatattaaaa caaatgctgg ttctgttgca aagtaaaaaa atatagctaa
     3181 ccactaattt atcatgtcag tgttcgctta acttgctagc atgatgctaa tttcgtggca
     3241 tggcgaaaat ccgtagatct gaagagacct gcggttcttt ttatatagag cgtaaataca
     3301 ctcaatacct tttaaagtat tctttgctgt attgatactt tgataccttg tctttcttac
     3361 tttaatatga cggtgatctt gctcaatgag gttattcaga tatttcgatg tacaatggca
     3421 gtcaggttta agtttaaaag ctttaattac tttaaccatt gctaccttcg ttgaaggtgc
     3481 ctgatctgta attacctttt gaggtttacc aaattgttta atgagacgtt tgataaacgc
     3541 atatgctgaa tgattatctc gttgcttacg caaccaaata tctaatgtat gtccctctgc
     3601 atcaatggca cgatataaat agctccattt tccttttatt ttgatgtacg tctcatcaat
     3661 acgccatttg taataagctt ttttatgctt tttcttccaa atttgatata aaattggggc
     3721 atattcttga acccaacggt agaccgttga atgatgaacg tttacaccac gttcccttaa
     3781 tatttcagat atatcacgat aactcaatgc atatcttaga tagtagccaa cagctacagt
     3841 gataacatcc ttgttaaatt gtttatatct gaaatagttc atacagaaga ctcctttttg
     3901 ttaaaattat actataaatt caactttgca acagaacctc atttactata tgggcatctc
     3961 tttcattatt aatacaaagc tttgtatctc cgatattagg caaaggtgta aacgaattag
     4021 gtgatactat aggattcaac attatattaa tcgtttcttt aataatgatt atcttcttat
     4081 tttttataaa tcgtagtaaa aatatctcct atgattatat aaaagttcaa agaggtgaag
     4141 ccaatgaata aattagaaaa atggtctttg gtatttatta tttttacatt tctctcttca
     4201 ttagcacttt tatatttcaa atataatttt agttcggtta tgccagtcct aagtctttct
     4261 attttaacta tactaatatt gttgacgagt attattactg tagtttcagt taatgatgaa
     4321 gatacttaaa acgttcatta gtgaaacagg tattatatta aaaaagcgta cgaatttgta
     4381 cgcttttttc ttgtgttatt attaaaatct cataacagga aaatattatg agattttaga
     4441 cgctgtcaga acgtctcttt tacatcgagt gacattgaat caaagtcttt gtatgttaat
     4501 gatatataaa attatttagt agattcatta tagtaagcta gattagttgc tctacttgtt
     4561 tttattctct tttgcctcta atttattgag ataacgataa atagttgtac gtgaaacttg
     4621 ccactgctct gcaattgttt taattggcgt accattatca taaagtgtct taagtaagtt
     4681 taaatcttgt ttatttaatt tttcaggtct acctccatat cggcctctag cacgtgctgc
     4741 aattcgaccg gctgatgatc gctctaaaat taaattacgt tcaaactctg caaatgctgc
     4801 gaataaatga aataataatt gtcctgtaga acttgattta tccatcgtta tattttcttc
     4861 taaactatga aaactcacac ctcgttcgtt aagttcatta actaacgtga ttaaatcctc
     4921 catgttccgt cctagtctat ctaatctcca aacaacaatc gtatctcctg acctcgcaaa
     4981 ttcaattgct ttatctaaac caggtcgctt actttttgaa ccactcatat ggtcattaaa
     5041 tatcttttca caaccatatg tatttaatcg atcctcctgt aaattcaaat tttgtaatcc
     5101 agttgaaact cttgcataac ctattttcaa aatacagacc tcctatatac acctttagtg
     5161 taccataact tgattacgag gtcttttgtg aacatagatt ttttgttggg tttttgaaca
     5221 cataattcta tgtaatacat acttatttag acataaaaag agagtgtaca gaaaatggtt
     5281 attttatgta cactctcatc tttactaata tattttaaat gttattaaca aaactaattt
     5341 aataagagtc aagtatagtt tacatatgta taatgtttga aacatatctc taattacttt
     5401 ttactaatat catttaaaat gtctcgcaat tcttcaattt ctttgttatt taattcttca
     5461 tttttcgcaa aatttagcac taaacttttc atgtcccctc catacagttt attaagaaaa
     5521 gttttagcag ttttcatttt aatatcgtct tctttaatat ttgatgagta aaaataaata
     5581 ttctctgatt tgtatcgttt tataatctct tttttatata gtcttgtgat taatgttcta
     5641 attgttttat cgctaacttc tttatatttt tgaatttcaa ctacaatttc attagctgat
     5701 actgattttt tatcccatat tatattcata acatcccatt cagccataga tatttcaact
     5761 tgcttattgg ccatttaaaa cacccatttc ttttaatatt ttttcactga ttaattcagc
     5821 atttttccca gacgggtttc catctgataa atgtgtagca aaataatact tatcatgatt
     5881 tgtaattacg taacctacaa accacccatt attatacttc ccgtttacta tacctgtacc
     5941 tgttttccca tacagttcat acttttcatt tttcttaatc aataatgaag aagataattg
     6001 attctttgct tttttactaa aatggttatt ttgttccatc atatttttaa aaactattac
     6061 ttgttcaaga ttagatattt tcaaactatc ttccatccaa tagtttttat aacttcccaa
     6121 attttcatta ccataattta attgcttgag ttgagccgca gtatagttct ttggtatttg
     6181 attactaata cgttcgaagt accaattaac tgaattttgc attgctgtat ttaaatcttg
     6241 ttccttattc caagactcga aaggataatg tttatgattc catgacatac gtgaattttt
     6301 atcacttatg atatgacggt caagtccaaa catcgctaaa taaattttat aagttgaatc
     6361 aggagaatat ctttttctac tttctttttc attataaata tagtatttgt ctttcttcat
     6421 gctgtacatg acgaaagatc cactatttga accaaaattt ttactttcat ctaaaatttg
     6481 gtgatcgttc tgtaagggct ttttataatt ataatcagtt atggattgcc ccatcaaaaa
     6541 ctggctttga attactatga gcaaaaaagt aaaaatacaa ataaaaattg gaattaattt
     6601 agactgtttt ttcaaattgg cttcttttat attaattaat cttcttttga gtaatgactt
     6661 tttaccatta aatgaatggc ttaatatatt tttattaaaa aatggaatat ttaatacgga
     6721 gtccataata gattccgcat aagttttaaa ttcatttttg ttaatattat taagaacaaa
     6781 tctatcagct tctacttcat tgtcatgaat tatctttctt tttacaatat gtattaatgg
     6841 attgtaactc ataacaatag agaagatatt aaagataatt aaatgtaaag tatctctatt
     6901 tttagcatga gcatattcat gcagtattat atattttagt cttttatcaa ttacactttt
     6961 aaaatatgaa ctaggaatca aaataatata tttcccatac caaaaagtta ttggagattg
     7021 aatagcctct gcttttcgaa tcacaatatt ttttttatat tgatggttga aaagtatcgt
     7081 atctatttta tttttttcat tttcgtttag ataaagtgac tgtttcttta aatatttaag
     7141 atataataag gctttcaaaa atttaaaact taaaataata actaaaacta tccaaataac
     7201 tgtgcagata ttatcaattg aatcccaatt aaacttatgg atatctgttg tgaactcttg
     7261 aataggtttg gtggtattta tgttatggtt caaatcgtgt gacttacttt caactgtggg
     7321 cgcttgatta ttcacattat taaattttat aaaagagaat ttaattggga taaaaggaat
     7381 taatccagca agcatagtta gataccaaac tttataattt aaactataat taaaatagcg
     7441 ttttaatatg tacctaaaaa atactaacaa tagaaatata aaacaaaagc ttactacgct
     7501 cattattagt aatttagcca ttttgacacc ttctttcaaa tatttataat aaacaattga
     7561 catcaatatt acaattgtaa tattattgat ttataaaaat tacaactgta atatcggagg
     7621 gtttattttg aaaaagttaa tatttttaat tgtaattgct ttagttttaa gtgcatgtaa
     7681 ttcaaacagt tcacatgcca aagagttaaa tgatttagaa aaaaaatata atgctcatat
     7741 tggtgtttat gctttagata ctaaaagtgg taaggaagta aaatttaatt cagataagag
     7801 atttgcctat gcttcgactt caaaagcgat aaatagtgct attttgttag aacaagtacc
     7861 ttataataag ttaaataaaa aaatacatat taacaaagat gatatagttg cttattctcc
     7921 tattttagaa aaatatgtag gaaaagatat cactttaaaa gaacttattg aggcttcaat
     7981 ggcatatagt gataatacag caaacaataa aattataaaa gagatcggtg ggatcaaaaa
     8041 agttaaacaa cgtctaaaag gactaggaga taaagtaaca aatccagtta gatatgagat
     8101 agaattaaat tattattcac caaagagcaa aaaagatact tcaacacctg ctgctttcgg
     8161 taagacttta aataaactta tcgcaaatgg aaaattaagc aaagaaaaca aaaaattctt
     8221 acttgattta atgttaaata ataaaagcgg agatacttta attaaagacg gtgtttcaaa
     8281 agactgtaag gttgctgata aaagtggtca agcaataaca tatgcttcta gaaatgatgt
     8341 tgcttttgtt tatcctaagg gccaatctga acctattgtt ttagtcattt ttacgaataa
     8401 agacaataaa agtgataagc caaatgataa gttgataagt gaaaccgcca agagtgtaat
     8461 gaaggaattt taatattcta aatgcataat aaatactgat atcatcttat agtttgtatt
     8521 atcgttgaca tgtataattt tgatatcaaa aactgatttt ccctctatta ttttcgatat
     8581 ttattttctt aattctcttt aacaaactag aaatattgta tatacaaaaa atcataaata
     8641 atagatgaat agtttaatta taggtattca tcaatcgaaa aagcaacgta tcttatttaa
     8701 agtgcgttgc ttttttctca tttataaggt taaataattc tcatatatca agcaaagtga
     8761 caatagcatt ttacaagtat tttttattgt tcgattaggg taaacctaaa taatacataa
     8821 attatattac aatatgttta ttatagaggc taaagtatct tagaaatttg gatagtaggt
     8881 ttttcgggaa taaaagtata gttggcttta atatataatt aagctaagct atcatttata
     8941 tttactcgat tataattcgc acttcaactt ttttataacg taaaaattaa aacgtagttt
     9001 tatttatctt tagtaatatc tttttaaaca ctacagtttc ttcattagtt aaattagcga
     9061 agtaatgatt attaagttga taggctttct tttctaatgt tggccataag tcttttgctt
     9121 tatttgtact gtttattagc acagttcttc tattttcatt atcagtttga cgtgttatta
     9181 gatccttttt ggacatctta tctaatattc cagatattgt tgaaggttct aaatttaaag
     9241 tattaccaat cgctttaggt gtattcaaat tactattaat caagcaattc aaaacaccat
     9301 attctgctgg agtaatatta tagggactta ataaactttt aaaatgttta aaaactctat
     9361 tctgagaagt actcaacaaa taatttatac aattatctaa ttccacaact aaaacctctc
     9421 ttaaatcatt agtattgact cgcttatcat atcatgataa gttttgtagg aaaatagttt
     9481 tgcaacaaaa acatacttct acaaaacaat tgtgaaagaa ggctaataaa tgttcaatgc
     9541 ggtagtagtg agaaaaagtg catcaaatgt tagttataaa gtagaaaaag ttgatgaatc
     9601 tcatttatcg aagggtgatg tattagtaaa agtggtatac tcttcaataa attataagga
     9661 tatgctagct ttacaatata aaggcggtgt aattagagat tatcctatga ttcctggtat
     9721 agattttgca ggtattgttg aatcaagttc gaatgataag tttaaagaag gcgataatgt
     9781 attagttact ggttatgatg ttggcgtgac acatacaggt ggattttcag aatatgcaca
     9841 agtgcctgga gagtggattg ttcctattcc ccaagaaatg tctattaaag agtctatggt
     9901 atatggcaca gccggtttta cggcagcatt atcaattttt gaactagaaa aatatggaat
     9961 gaatatcaaa tcacaacctg aaattttagt gtctggggct acaggtggtg tgggcagtgt
    10021 tgctatacaa attttacata aaattggata tgaaaatatc actgctatcg taagaaaaga
    10081 aaagcaaata gaaatcgcaa aaaaattagg tgcaaaacaa gtaataataa ttgaagatga
    10141 taataaaccg cttaaaaaag gtatttttga ttatttctta gatacagtgg ggagtaatgt
    10201 aacattatac ggtttaaaac gtctaaatta tcaaggtgtt gctactgtat gtggaaatgt
    10261 agcaggaaat tcacttaacg ctaatatatt accgtttatt cttagaggta ttaaattaat
    10321 tggcattgat tctgtatatg ttgatcataa tatccgtgaa gatatatgga gtaagttagc
    10381 aaatgaatgg aatataggaa attcacttct atacaatgaa attggatttg aagaattcta
    10441 taaaacgata gatcagcttt taaaaggaca acatttagga agaactattt taaaagtata
    10501 agtgtgagta ttcattaata catttactat taattcaatc attttgcatt tctctactaa
    10561 ccagtgttat aatttatata acgaaaatga ttaacaatta atgcaccaat ccccacacta
    10621 ttgcagtagt gtggggattt tttcgatgct ggcttataaa gtcgcctatt aattatttgt
    10681 tgcgtttact aagccaataa gtataatacg caacagcaca gccactgatg actggtgcta
    10741 tgatgtgaac gaaaatgatt agcaaagtaa tgcacctcct ctcttcgtca attgacgcct
    10801 gagagatagg cgactctatt attataccat ctgtgaatat acaagcatat ctacttccga
    10861 taagtcgtct tatgttatat aactttgttt tttatagtat caagacaaga agaaactcgt
    10921 ttcaaaaacc ctcatgattt ttagagaaaa actctcttat ttcatcgtct ttaataaaat
    10981 aatatgccat ctttccatct ttataaaaat caagtacctc atttttatat aaaagcctta
    11041 aatgatgtga agttgaagca acactcattt tcaatatcaa agaaatatca caaacacaca
    11101 actcatcttc tttaatcaaa gataatatga ttttcaattt cttctcatca caaatttttt
    11161 ctaaaatgtt aagtaatttc ttagatttat catcttctaa aaaccttaaa gcattgttaa
    11221 ctttatcctc atgtacacag atcacatcac aagtattttc ataactcata taaaatcaca
    11281 ccctaaatta aaatataaat cctaaaattg tttgaatagt gtcattttca ataataataa
    11341 ataaacctaa agctatataa ataatagcca taatccaacg actaaatttc tcaacaattt
    11401 ctccaattcc tggaatatta gctaattttt gtgcagtaaa caccaagaag aaaattaaaa
    11461 ttaaaaagac aaacagagta agtaataaat tagtaacact taatgtcaca aaatacggaa
    11521 caaataaacc aatattatcg gcgccacaac ttgctatcgt aacaattgca accgtaccaa
    11581 ctaatttaga caatcctttt tcattcaatt cttttttagc tctcttttct ccttcacaat
    11641 catcataaat agccacttta attccaagat aaattggtat taaacccaat aaacctaata
    11701 tccacttttc tggaacataa tttaatacaa aagctaaaaa caaactaact aatattaaaa
    11761 taatagaccc taaatattga ccaacataaa tatctctata ttcttttcta gtctttgctc
    11821 tagcaaaaaa tattaataaa attactaata aatcaactgc tgtagcaata taaagaacag
    11881 cagcagcaac aaccgtttga atcataatac acctcattca aaaatatttt tgaatgtatt
    11941 ataacttata tttttaaata atcataggtg ctttattcca attgctttat tgacgttgag
    12001 ttgagcctcg gaacccttaa caatcccaaa acttgtcgaa tggtcggctt aatagctcac
    12061 gctatgccga cattcgtctg caagtttagt taagggttct tctcaacatc aataaatttt
    12121 ttcggcataa atgcgtgtct atgcgtagac atggagacac ttcagaatta tggagtgatt
    12181 acatgagttt aactattttt ctttattcag ttttaggaag tttattagca aattatatct
    12241 acgaaaaatc ttcaaaataa ataacttttt cggttctatt ttgtacactt tatctacctg
    12301 gtagacctaa ttgttattgc tttacaggtc taaaattcgt cgttataatc tagttaaatc
    12361 ccgtaagggc gcacttatac gtcggataaa tcgacatgtg caaaaacgta atcgaccttc
    12421 gtcgattttt ttatttcaaa attaaagaaa cggcttgaga tattccgagc agttataaaa
    12481 attaatttgc gttgaatatt gctactacat tcttgaaaaa gtgatgtaga tttatagccc
    12541 ataacttttt tgaattacat cgacgatacg gcgtcgaaag aaaaataaat agaccgtatg
    12601 aaagaaaaag ctacctcact ttatctgggg tagcttttat tttttatgcc cttattttga
    12661 attttaagag ggcattttaa agatttaggg gtgattcata tagttttata tctaaaactt
    12721 atatatgctt ttaaaacgca aatatgagcc aaataaatat atgctatttt caaaaacaaa
    12781 aatttgagca aaaacaataa ctatttttag acactgccca tttacatgca aattaaaaat
    12841 tagcataaaa ttctttaaaa cttccccacg tttttctaaa ttcctgtagg gcgtttttat
    12901 caaaaatcaa gacaagaaga aactcgttca cactcgtttc aaaaaaacaa gaaatctaat
    12961 ctatacacct accgttttcc aaccccctca aagcatacaa attaaaaaca aaattattca
    13021 taatcttact ttcttttaac aaaaacataa aaaccataaa tagacaaatt aactatcaaa
    13081 ggcaataaac agtataaaaa aaccacgaat aaatcttcat caacatctaa aataaaaaag
    13141 aataaaacaa ttaacaaaat actaattaac aaacctaaaa gtggcaaact ttttatatat
    13201 ttttctaaat tttcattcat aaaatagact cctttcaaaa atatgtttat aaatatatta
    13261 aaataaatat tgattttata aagcgcttac ttatacaatt aaaatatctt attatcttgg
    13321 aggtatcaaa tgaaaattat aaaattattt tcaataattt ccttgttcct actggtattt
    13381 agcgcgaatt tttctaatgc ttacgcaaat gaagaacaaa aaagttcttt actagaaaat
    13441 caaaaagaaa aattgaaaag caaaaacatc gaagtatcac aaatgaccaa gaaagaaata
    13501 agttttctag aacaattgca aaataaaaat gaagatatgc aaaaattcga aaagcaaatg
    13561 aaaaaagaag gatttaaaaa aataaagcta gaagacaaaa attctaaatt aaaatatcta
    13621 gctacagaag caaatgataa aaatgcatat ggctacatag ctaataacgc ttataaaaat
    13681 gaaaaaacaa aagaaattgt agtttctgaa acaatatatg ataactacaa caaaaaaatc
    13741 acaaaattca ttgccgaaaa aagaagtatg actgaaaaca aagagggaaa aatacttatt
    13801 aacaaaaatt acgttgaata taaggctgaa aaagttgata aaaacagacc ggtaacatat
    13861 gcaggattca aatggaacgg caaagcattc gcttgtagta tggctggact ttatgcatgt
    13921 gctcactact gtggagtatg ggcaatcgta aatccaatag ccggcggtgt atgtgaagca
    13981 gtttgcggaa ctgcatttgc agctggatgc tctgtaggtt gattttattc caattgtttt
    14041 attgacgttg agcctcggaa cccttaacaa tcccaaaact tgtcgaatgg tcggcttaat
    14101 agctcacgct atgccgacat tcgtctgcaa gtttagttaa gggttcttct caacatcaat
    14161 aaattttttc ggcataaata cgatgttcct tatttatcct cataaaaaac aatagctgaa
    14221 atatataacc aattactgtg tgtttgaatt tctaatacat gaatatcatt ctttaaaaac
    14281 ctattaactt gtttatctaa ttgacgatga gtaaaagtag cgaaagtttt aatcttcatg
    14341 atatctctcc ttttataaaa atagcaatcc ttattacaat attaaacact tttattttgg
    14401 attttaagag gcattttgaa gacttagagg caaatcatat aggttttgta cttaaaaatc
    14461 tatacagtct cttaaaacgc aaatatgagc caaataaata tatgctaatt tcacaaacaa
    14521 aaatttcagc aaaatcagtg actaattttt tagatactgc ccatttacat gcaaatttaa
    14581 aaattagcat aaaatacttt aaaacttccc catgtttttc taaattcctg cagggctttt
    14641 cttatcaaaa acttagaaat tttaatttaa ctctaaaatc tccgtaagag cataagggaa
    14701 atttgctatc attcaaaaat gatagatctg gcaaggccag acattccaag ggttttaagt
    14761 tattttaaag tgatatcata caaagctgta gtgtcacact tttgtgacac tacatacagc
    14821 atttgtcaca aaaataagac agcacttttt tacagaaaaa caataaaaaa agacatcagt
    14881 tatcactaat gtcttaaata ataattttgc ttttcgaaat tccaaattgc ggtaattgaa
    14941 tgtgcttttt ttcttcgtct gtcgttttat cttcatcact tgtattaatc aaattaccat
    15001 cttcggcatc gtctaagttt aaaattttat gcttttgttt aagcaatcca ccataactta
    15061 acatacgttt tcgatacaaa cctttttcta aatcacttac aatttcttga tttttttcgt
    15121 cgtcatcagt taaaaagtca gatgatttaa cggaatattt tgatgtctct tcgagtgtta
    15181 taaaatcatt tgaattattg attaaagata ttatattgtt tcatgttttt acggcgcata
    15241 taaagggcat gtgtttcttc aagttcagtt agaattgttt gcattaaata agcttgcatt
    15301 gacttgattg tttccttttg gcctttaact cccctatcat gtatagcttt tttaagtctt
    15361 tttaaagaag ttaatatttc atcctcaatg tcctctaaca tgtaatgcat atcttcatgc
    15421 cttgaattaa atgatttttt tgctttaaga ataacagcct ttatgatttc taaatctcta
    15481 taatcatatt ttaataaata attagttagt tgttctggga attcttgcaa tagcatttct
    15541 ttatcatcaa aattatgtgt aaattgattt gaatgatttg aatgattact aatttcattt
    15601 ttgtacttta tatcattcaa gtcattcata tcattattct cagtatcatt aaagtcaatg
    15661 tcattaaagt cagtatcatt agtgttcgat tttcgaactt ctggacgttc gattttcgaa
    15721 cttctggacg ttcgattttc gaacttctgg acgttcgatt ttcgaacttc cttctcgccg
    15781 taaggttcaa catcgttttc ttctttttct attttgtaaa tatcacgttc tgtgacaata
    15841 ggtttcatta aatatagaat atttggttta tttaaaccac gtcgtttttg aatgagtaga
    15901 ccatcgtttt ctaacccttt ttttattttt gttaactttt cttttttaca atttaagatt
    15961 tccattagct tttcatttga ataaacaaag taaatgttac catcttcatc aacccagcta
    16021 tttttaatag ataaatttaa gcgatcacgt aagatagcat aggctatttt catatcatta
    16081 gttagatttt tataattttc actggtaaag aatactttag ggatttgata aaatctttct
    16141 ttgtaatttt cttgcactgt aaaatattga ttttgcatga caaaaaacct ctttccatat
    16201 tttagtttgg taagaggtaa taaaacgttt ttatttagct ttacatttat ttaatgattt
    16261 aggtgcttgc actaagatat tattcattat ataatacaag tatcgaaaat tatataaata
    16321 aacagtttct aaacgtttta ttaccaaacc ccgactatta ccagtagttg gggtttttgt
    16381 tatattaagt ttattatagc actttaaata aacttataaa agggaaaata tagctttatc
    16441 aagggtttat aaacccttga taaatatcat aaacctttca taaacccttg ataaaaaggt
    16501 tgatggatgt ttatttttat ttattaatca ctttattatt aagcattata agattataat
    16561 attttatcaa gggtttataa acattttata aagggttgat gatatgaaaa gtgtgaaaaa
    16621 gttgagtgaa gaattagggg ttagtaagca aacgattttt aataatatta agcgattgaa
    16681 tatagagaca ataaaacagg aaaacacttc gtttattaaa gaagataccg atatagaaaa
    16741 aatcattcaa agagtaaatg aaaataaaaa gaaatatggt tttgaaagta ctactgaaga
    16801 caaacaaaaa aaagggtcgg ataatattaa ttttgaatcg aaaagcgatg ctcaaatagt
    16861 agaaatcctt aaaaatcaga ttgatacttt aaataatcaa attgaaaaac aagaaagtcg
    16921 tcatgaaaca acaattgaat tttacagaaa agagttgcaa gaaagatcaa aattgcttga
    16981 aaatcagcaa gttctggcat tagagagtaa taaaaagatt caaaaattag aaaatcaatt
    17041 agaaaaagaa aaacacctta attatccctt tgatacatct actaacacta gacaaaacgt
    17101 tgatgcacaa gaaaaaacat atactactaa tcctgtaaat attaacagag atcaggaaga
    17161 aactaaagaa acagagattc aatataagga tatatctgga agtcaaagcg acgaaagtac
    17221 acaaggtgaa gaagcaaaaa aagaagacgt tccagctaat ctaaatgaca atgatagtga
    17281 tatagaagaa aagagtgaag aaacggaacc taaaaagggg ttttggagtc gtttgtttgg
    17341 tagctaaaat aattgattag gcactaaaag ttataaaatt ttagtgtctt ttatatagtg
    17401 agaacttctg gtaatcatcg attatgtaaa ctaaagtatt tcaaataatt aactgtatta
    17461 atactctcat catgattgcg ttataaacgt tcatttgaag gtcatctcta tcataaatat
    17521 ttaaattaac taaaaatttt aatcatctgt ttaatactta tgaaatgtat ttacggtagg
    17581 tattaaaatt gatgaaattt atataagtgc tttcaatgaa aatgaccgtt tatttatcct
    17641 cctgatttaa ggagttagaa atttcgaaaa cgattctttc catttgttgc atttgttcca
    17701 tgtccagata tttaatacat tatagaaaac caaagaccat cactaattaa acgcagtttt
    17761 aaaatttcat caggattgcc ttcgtcttta aaatgggcct cttttaatat aagttctact
    17821 ctttcatacc taactctttc aatgccatcg tttcatacgc cgattctcct gattccatag
    17881 caaactcagc gataaacatt gggaatactg cattgagttc tattatatgc tctttcattc
    17941 gtggccatat ttcacctcca gctttaccgt atgctgttat aagttgctct aatccttcgt
    18001 cgtcgaatac acgatggtgt cctataaagt ccattgatgg gtcggagtgg gttgcttcag
    18061 tccagtctat gagacctgtg acgtttgctt ggttatctac cattatatgt cctggatgta
    18121 agtccccatg tatcatggtc gcatgtcgag gccatagttc gtcgttttct aaccattgtt
    18181 tccatctgtt ccataattca tctgatacgc cataagtttc tttaacttta ttcattcttc
    18241 tttgaaagtc attttttatt tcttgtatgg ttttgatatt tatatgctga acgttaatgt
    18301 tttcttctgg tatgttgtgt aaatctacga gtgtttcagc taatgtgtta ataaagtttt
    18361 ctggtaatgg tttgtgttca atttcccata cataattttg tatttctgga tctattgtgg
    18421 ctgcgggttt acctgtaagt tttgggtaag caataaggtc ttttgcatgt actttccact
    18481 tcggtatttc aaatgaaaca ttcttctgta agaagtctac cgtttgtttt tcgggttttg
    18541 ttcgtttata aacgtcaggt cttcttggta gtctcaaaac ccattctact ccatgtttat
    18601 cttttccaaa tgcaacttga aaatcaagtc ccgattcatt caatgagatt gtttgaggtt
    18661 ggatgtgtaa ttgatatttt tctgcacatt taataatttc attatgtcga gtcattttat
    18721 tggatcctta tttctattat atttttcttg tgaacgtatt ttttatattg atataaatga
    18781 acctaatatt caatataaat tagtgtatag tttttaagtt atatcatgaa gagattgtcc
    18841 tgttaattcc cattttttat ctgatacatg tttaacaaac cttgtatcat gtgatgtaaa
    18901 caaaatgatt ccaggatatt tattcataaa catttctaat gcttctaatg ttttaatatc
    18961 taaaaaatta gttggttcat ccaaaattaa catattcgct ttcgttgaaa ataatactgc
    19021 taacgataat ttcgttcttt ccccaccact caaaacatta caagaacgat caagtgcttc
    19081 atttaaaccc aagttattta aaatagctct actgaatgat tctgatgaat ccgtttcatc
    19141 cattaaatat tgcaataatg aaacgtcacg catgtcttca taagcaagtt gacgatagta
    19201 tgccatttgc actttaggag aacaatcaat tccctctatt tggtggtaaa tagcttcaag
    19261 taaagttgtc ttacctacac catttgcacc tacgagcgct atatttttgc catatggtat
    19321 ttggaatcgt acttgtgtta gcagtttttg acttccttta accaatgtta gattttgtgc
    19381 aatgattgga taattattat ggatatcata aattttattt tgtgggaaat tgaattcatg
    19441 ataactttgt ggtttttcaa cttcttccaa atgttccatt cttttttcaa tatgcttagc
    19501 ttgtttttga gcagccttct caaccgtgcc tttttgtttt gatgcactta aacgatctgg
    19561 tgctatactt ttgttttttt gttttgatga tgcttgtgcc atttgttgcg cttgatttcg
    19621 tttagcttta ctggcttggg acaatctttg tttttcactt atatactgtt catattgacg
    19681 ttgttgttct aactgttctt gttcatattg attttgatac tgtgtgtaat tacctttaaa
    19741 cactcttatt gtgccatctt cttgtatatc ccaaattgtg tcagcaattt ggtctataag
    19801 tgctctatca tgacttacta taattaaagt accatagtaa tattttaaaa tatttttcag
    19861 ataatcttta ccaattttat ccaagtgatt tgtaggttca tctaaaagta atatcggact
    19921 ataatttgat atgacattag ctaatttata ttttgctttt tcaccaccac tcatactgtc
    19981 ggttgtatgc ataggtatat ggagttcact cattaaacta ccgtctaacg tgttaaaatc
    20041 attttccaca tccatgttaa gctgttcaaa atattgaatt tcgccaaccg tttcaactgt
    20101 tccagattct ggttttgttt tttgagcaat catatttagt aatgtggttt tgccagtacc
    20161 attaccccca ataagtgcta ttttttcaaa ttggtaagcg taaagatgac cgatgttaag
    20221 tgatcgtaaa tctgtcaatt tatgattgat ttggttaaat ttaattgtat attgttccat
    20281 atttatacac tccttgtata tttaaaggac gtgtacgcaa aaaaatgaga caggctactc
    20341 ccgtctcatt cacattacac tttcaaacac ttaaaaattt attatgatgt tttagtattt
    20401 gaaagcgttt attattccta tcgaaggata aaaaatgaca taagtcatcc tatgagtgtg
    20461 tattgcggac aagccttttt gaattaattt agttttgtat tcaaaaaggt ttatttgagt
    20521 ctcatagaag ctgtcatttt aatcctcctt catcgataaa atagtaatgt taatataaca
    20581 ttttgttggt ttttttacaa tatatctcta agtagaaaga ttatataaca aaagtataaa
    20641 aatacaattt tagattgatt atacatctcc ttaatttaga gtgtactcat aaaatacggt
    20701 tctgttgcaa agttgaattt ataatataat tttaacaaaa aggagtcttc tgtatgaact
    20761 atttcagata taaacaattt aacaaggatg ttatcactgt agccgttggc tactatctaa
    20821 gatatgcatt gagctatcgt gatatatctg aaatattaag agaacgtggt gtaaacgttc
    20881 atcattcaac gatctaccgt tgggttcaag aatatgcccc aattttatat caaatttgga
    20941 agaaaaagca taaaaaagct tattacaaat ggcgtattga tgagacgtat atcaaaataa
    21001 aaggaaaatg gagctattta tatcgtgcca ttgatacaga gggacataca ttagatattt
    21061 ggttgcgtaa gcaacgagat aatcattcag catatgcgtt tatcaaacgt ctcattaaac
    21121 aatttggtaa gcctcaaaag gtagttacag atcaggcacc ttcaacgaag gcagcaatgg
    21181 ctaaaataat taaagctttt aaacttaaac ctgactgtca ttgtacatcg aaatatctga
    21241 ataacctcat tgagcaagat caccgtcata ttaaagtaag aaagacaaga tatcaaagta
    21301 tcaatacggc aaagaatact ttaaaaggta ttgaatgtat ttacgctcta tataaaaaga
    21361 accgtaggtc tcttcagatc tacggatttt ccccatgcca cgaaattagc atcatgctag
    21421 caagttaaac gaacactgac atgatatatt agtgattagc tatatttttt actttgcaac
    21481 agaaccagcc atttaatatg actgttacaa ttactaagat tcaagcacta ttacgccgca
    21541 cgtatgattt caccactcaa gttaataatt taacagtaga tgattgcgag ttactacttg
    21601 atgcagcaaa gcttaaattt aatgaagaaa ccatagacct gacacacact gaattgcaaa
    21661 tcatgcatag cttattccag aacaagggca aattcgtcag tcgtaatgcg ttaatcgaaa
    21721 aatgctggga atcagaacac ttcattgatg acaatacgct tgctgtcaac attacacgtt
    21781 tacgcaaaaa gctacaaaaa ctaggactta cagattttat cgaaacgaag aaaaatgtcg
    21841 gatatcgtgt aggtgacgta tgaatttctt gaaatcaatc caacgtgaaa tttatattgt
    21901 catccttact tgtgctttat tctactttat attattcatg tataatgtgc cgatgcaagc
    21961 atatatgatt ggtctaggta ttgtattgtt tgtttcaatg atttactggg gtatccatta
    22021 catgaacttt aaaaaagaat aaacactaca ggaacagaac gaagatttaa gaatcgaaaa
    22081 ccataaactt cgtaatgact ttattaacta ccaaagtgag ttagagtcat attttttaat
    22141 gtgggtgcat caaatcaaga caccgattac agcatcaaag ttactgcttg aagatcctga
    22201 tgaacacgtg atttctaacg tgcgtaatga agtcttacaa attgataatt acacgaatct
    22261 tgcactgaac tatttgaaac tcatgaacca aaagacatac atggtcttta tggaagtgag
    22321 tgtagatgaa ttaattcgac cactgattaa acgttatgcg atacagttta ttcatcatca
    22381 aacaaagttg cattatgaga aaagtgaagc ggttatatta acagatgcca aatgggcatc
    22441 aattatgatt gagcaaatat taaacaatgc attaaaatat gcacgtggca aagatgtgtg
    22501 gattacgttt gacgaaaata caaagaaatt atcaatccga gataacggta tcggcattaa
    22561 tgcgagtgat ttaccgaaaa tctttgataa aggtttctcg ggctataacg gtagaataag
    22621 tgagaaatca agcggtattg gtttatatat tgtcagcaca atctcaaagc gcttaggcca
    22681 taaagtaagt gctacatcta cattaaacga tggttcaata ttcaccattc aatttaaata
    22741 actccaatct ttcatttttg taagattagc ggctgttttt gtaagaatag ataaaggcag
    22801 ccttttctaa tcgcgcgtaa gataaaggta acaacaaact aagaaaggtg ccagaggtga
    22861 aaaatttgaa taatataatt gaaataaata acttaacaaa gcaatatgga agtcagatag
    22921 cagttaataa tttgagtata actgttgaaa gtggacaaat ttatggtttt ttaggaagaa
    22981 atggtgcagg caaaacaact actataagaa tgcttttagg cttaattaaa cctacgaaag
    23041 gtaatattaa aatatttgaa aaagagttcg aaagtaataa aactgaaatt ttaaaaaata
    23101 ttggtgctat ggttgaaacg ccaggttttt atagtaattt gacagctaaa gagaacttaa
    23161 ctataaatgc taaaatatta ggtatacaaa aagaaaatgc aattgaagaa gtgttagaaa
    23221 tagtaggact agcttctgaa aaagtaaaat tgtttaaaaa ttattcttta ggtatgaagc
    23281 aacgtttagg gattgcgaga gctttattgc acaatcccga attattgata cttgatgagc
    23341 cgacgaatgg attagatcct attggcataa aagaaattag aaagttgatt aaggatctgg
    23401 ctcaatctag aaatataacc attttaattt caagtcatat attgtcagaa atagagcagt
    23461 tagtagacaa ggtgggtatt attcataacg gagttttgtt agaagaaatt atgtatgaag
    23521 atttaaaaaa aagaacagac aatttataag tatatcagta tcagatgaag aaaaagttgc
    23581 atgtttgttg gaaactaact tcggaattta tgactataaa attaaagaaa atggcgaatt
    23641 taaaatttat tcacatattg atagacaaca agaaattaat agattattag tattaaacaa
    23701 tattgatgtt ttccagatga gagtgataga agataatcta gaaacttatt tcgaagactt
    23761 agtaggaggt ggcacaattg gataatctac tccgtacaga atttattaag ttaaaaagat
    23821 catatatgtt tctaataagt attttaggta catgcgtagc accttttatg gtggttgtag
    23881 cttcttttat tagtatgcgg acgaaagtac cgactcctaa tattgtattt aaacagttat
    23941 ttgaagaagt cagtttatat catatgctaa ttattggacc tcctctatat ggggttataa
    24001 tagcctattt gtttggaaga gaatatatag aagatacttt aaaaaactta ttaattatac
    24061 ctatatctag agaaagtttt ttagtaagta aaataatatt attattcttg tggattcaaa
    24121 cactatctgt tattgcatgg ttgctaactt taatgctagg tatgctattg cattttcaag
    24181 ggttaagcca gagtttaata attgattcat tctttacatt tgttattggc ggagtgttat
    24241 tatggatatt atctccacca ataattattt tgtcgatata ttttaaaaat tatgttccca
    24301 caattgtttt aaccataata attactttga taaatttaat gactgctaat tctgaacata
    24361 gaggattatt tccttgggct gcagttggag acatatctag aggaacatta cctaatactt
    24421 atccatttct attatcttta attatcataa ttgttacatc tatattcagt gtaattatat
    24481 tattctcata ctttaaaaaa actgatataa gttaaaagga ggagaaaaat gggttttata
    24541 gagcagatta aagcatttat tttaggtgta gttgaagggt tgacagaatt tgctccagta
    24601 tcatcaacag gtcatatgat tattgttgat gatatgtggt taaacactgc tgacgattta
    24661 ggaagtgcgt ctgcaactac ttttaaggtg gtaatacagt taggaggttc tgttgcaaag
    24721 ttgaatttat aatataattt taacaaaaag gagtcttctg tatgaactat ttcagatata
    24781 aacaatttaa caaggatgtt atcactgtag ccgttggcta ctatctaaga tatgcattga
    24841 gctatcgtga tatatctgaa atattaagag aacgtggtgt aaacgttcat cattcaacga
    24901 tctaccgttg ggttcaagaa tatgccccaa ttttatatca aatttggaag aaaaagcata
    24961 aaaaagctta ttacaaatgg cgtattgatg agacgtatat caaaataaaa ggaaaatgga
    25021 gctatttata tcgtgccatt gatacagagg gacatacatt agatatttgg ttgcgtaagc
    25081 aacgagataa tcattcagca tatgcgttta tcaaacgtct cattaaacaa tttggtaagc
    25141 ctcaaaaggt agttacagat caggcacctt caacgaaggc agcaatggct aaaataatta
    25201 aagcttttaa acttaaacct gactgtcatt gtacatcgaa atatctgaat aacctcattg
    25261 agcaagatca ccgtcatatt aaagtaagaa agacaagata tcaaagtatc aatacggcaa
    25321 agaatacttt aaaaggtatt gaatgtattt acgctctata taaaaagaac cgtaggtctc
    25381 ttcagatcta cggattttcc ccatgccacg aaattagcat catgctagca agtt
//
