LOCUS       CP049582               24934 bp    DNA     circular BCT 24-SEP-2020
DEFINITION  Staphylococcus aureus strain pt172 plasmid pER04823.3A.1, complete
            sequence.
ACCESSION   CP049582
VERSION     CP049582.1
DBLINK      BioProject: PRJNA470993
            BioSample: SAMN12330989
KEYWORDS    .
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 24934)
  AUTHORS   Caban,A.B., Pak,T., Kumaresh,A., Dupper,A., Chacko,K.,
            Sullivan,M.J., Altman,D.R. and van Bakel,H.
  TITLE     PathoSPOT genomic surveillance reveals prolonged under the radar
            outbreaks of nosocomial methicillin resistant S. aureus bloodstream
            infections
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 24934)
  AUTHORS   Caban,A.B., Pak,T., Kumaresh,A., Dupper,A., Chacko,K.,
            Sullivan,M.J., Altman,D.R. and van Bakel,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-FEB-2020) Genetics and Genomic Sciences, Icahn School
            of Medicine, One Gustave L. Levy Place Box 1498, New York, NY 10029,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 381.818834741784x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 02/28/2020 17:01:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 2,841
            CDSs (total)                      :: 2,759
            Genes (coding)                    :: 2,692
            CDSs (with protein)               :: 2,692
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 67
            CDSs (without protein)            :: 67
            Pseudo Genes (ambiguous residues) :: 0 of 67
            Pseudo Genes (frameshifted)       :: 39 of 67
            Pseudo Genes (incomplete)         :: 17 of 67
            Pseudo Genes (internal stop)      :: 22 of 67
            Pseudo Genes (multiple problems)  :: 11 of 67
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..24934
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="pt172"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pER04823.3A.1"
                     /geo_loc_name="USA:New York City"
                     /lat_lon="40.7903114 N 73.9528738 W"
                     /collection_date="2016"
                     /collected_by="Mount Sinai Hospital"
     gene            join(24733..24934,1..2)
                     /locus_tag="FPO35_14055"
     CDS             join(24733..24934,1..2)
                     /locus_tag="FPO35_14055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001627151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP kinase"
                     /protein_id="QOA01056.1"
                     /translation="MGFIEQIKAFILGVVEGLTEFAPVSSTGHMIIVDDMWLNTADDLG
                     SASATTFKVVIQLGGSVAKLNL"
                     /name="UDP kinase"
     gene            32..706
                     /locus_tag="FPO35_14060"
     CDS             32..706
                     /locus_tag="FPO35_14060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="QOA01033.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            847..1482
                     /locus_tag="FPO35_14065"
                     /pseudo=""
     CDS             847..1482
                     /locus_tag="FPO35_14065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032491779.1"
                     /note="internal stop; incomplete; partial on complete
                     genome; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside 6-adenylyltransferase"
                     /name="aminoglycoside 6-adenylyltransferase"
     gene            1479..2009
                     /gene="sat4"
                     /locus_tag="FPO35_14070"
     ARG             1480..2006
                     /name="sat4"
                     /gene="sat4"
                     /gene_name="streptothricin N-acetyltransferase Sat4"
                     /tool="amrfinderplus"
                     /drug_class="STREPTOTHRICIN"
                     /identity="97.78"
                     /coverage="100.0"
     gene            2102..2431
                     /locus_tag="FPO35_14075"
     CDS             2102..2431
                     /locus_tag="FPO35_14075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032491780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOA01035.1"
                     /translation="MAKMRISPELKKLIEKYRCVKDTEGMSPAKVYKLVGENENLYLKM
                     TDSRYKGTTYDVEREKEWYDIAFCVRSIREDIGEEQYVELFFDLLGIKPDWEKIKYYIL
                     LDELF"
                     /name="hypothetical protein"
     gene            complement(2539..2727)
                     /locus_tag="FPO35_14080"
                     /pseudo=""
     CDS             complement(2539..2727)
                     /locus_tag="FPO35_14080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002913594.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            2707..3278
                     /locus_tag="FPO35_14085"
                     /pseudo=""
     CDS             2707..3278
                     /locus_tag="FPO35_14085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001079940.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="HTH domain-containing protein"
                     /name="HTH domain-containing protein"
     gene            complement(3447..4121)
                     /locus_tag="FPO35_14090"
     CDS             complement(3447..4121)
                     /locus_tag="FPO35_14090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="QOA01036.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            4383..4568
                     /locus_tag="FPO35_14095"
     CDS             4383..4568
                     /locus_tag="FPO35_14095"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOA01037.1"
                     /translation="MNKLEKWSLVFIIFTFLSSLALLYFKYNFSSVMPVLSLSILTILI
                     LLTSIITVVSVNDEDT"
                     /name="hypothetical protein"
     gene            complement(4791..5369)
                     /locus_tag="FPO35_14100"
     CDS             complement(4791..5369)
                     /locus_tag="FPO35_14100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="QOA01038.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNKQDLNLLKTLYDNGTPI
                     KTIAEQWQVSRTTIYRYLNKLEAKENKNK"
                     /name="recombinase family protein"
     gene            complement(5633..6013)
                     /gene="blaI"
                     /locus_tag="FPO35_14105"
     ARG             complement(5637..6013)
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.21"
                     /coverage="100.0"
     gene            complement(6003..7760)
                     /gene="blaR1"
                     /locus_tag="FPO35_14110"
     ARG             complement(6007..7760)
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="98.8"
                     /coverage="100.0"
     gene            7867..8712
                     /gene="blaZ"
                     /locus_tag="FPO35_14115"
     ARG             7868..8709
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.29"
                     /coverage="100.0"
     gene            complement(9226..9645)
                     /locus_tag="FPO35_14120"
     CDS             complement(9226..9645)
                     /locus_tag="FPO35_14120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418035.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="QOA01042.1"
                     /translation="MELDNCINYLLSTSQNRVFKHFKSLLSPYNITPAEYGVLNCLINS
                     NLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRTVLINSTNKAKDLWPTL
                     EKKAYQLNNHYFANLTNEETVVFKKILLKINKTTF"
                     /name="MarR family transcriptional regulator"
     gene            9769..10740
                     /locus_tag="FPO35_14125"
     CDS             9769..10740
                     /locus_tag="FPO35_14125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="QOA01043.1"
                     /translation="MFNAVVVRKSASNVSYKVEKVDESHLSKGDVLVKVVYSSINYKDM
                     LALQYKGGVIRDYPMIPGIDFAGIVESSSNDKFKEGDNVLVTGYDVGVTHTGGFSEYAQ
                     VPGEWIVPIPQEMSIKESMVYGTAGFTAALSIFELEKYGMNIKSQPEILVSGATGGVGS
                     VAIQILHKIGYENITAIVRKEKQIEIAKKLGAKQVIIIEDDNKPLKKGIFDYFLDTVGS
                     NVTLYGLKRLNYQGVATVCGNVAGNSLNANILPFILRGIKLIGIDSVYVDHNIREDIWS
                     KLANEWNIGNSLLYNEIGFEEFYKTIDQLLKGQHLGRTILKV"
                     /name="oxidoreductase"
     gene            complement(10912..11004)
                     /locus_tag="FPO35_14130"
     CDS             complement(10912..11004)
                     /locus_tag="FPO35_14130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="QOA01044.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(11161..11508)
                     /locus_tag="FPO35_14135"
     CDS             complement(11161..11508)
                     /locus_tag="FPO35_14135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="QOA01045.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNHEGF"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(11527..12144)
                     /gene="cadD"
                     /locus_tag="FPO35_14140"
     ARG             complement(11531..12144)
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(13260..13454)
                     /locus_tag="FPO35_14145"
     CDS             complement(13260..13454)
                     /locus_tag="FPO35_14145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001004925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOA01047.1"
                     /translation="MNENLEKYIKSLPLLGLLISILLIVLFFFILDVDEDLFVVFLYCL
                     LPLIVNLSIYGFYVFVKRK"
                     /name="hypothetical protein"
     gene            13564..14256
                     /locus_tag="FPO35_14150"
     CDS             13564..14256
                     /locus_tag="FPO35_14150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOA01048.1"
                     /translation="MKIIKLFSIISLFLLVFSANFSNAYANEEQKSSLLENQKEKLKSK
                     NIEVSQMTKKEISFLEQLQNKNEDMQKFEKQMKKEGFKKIKLEDKNSKLKYLATEANDK
                     NAYGYIANNAYKNEKTKEIVVSETIYDNYNKKITKFIAEKRSMTENKEGKILINKNYVE
                     YKAEKVDKNRPVTYAGFKWNGKAFACSMAGLYACAHYCGVWAIVNPIAGGVCEAVCGTA
                     FAAGCSVG"
                     /name="hypothetical protein"
     gene            complement(14424..14573)
                     /locus_tag="FPO35_14155"
     CDS             complement(14424..14573)
                     /locus_tag="FPO35_14155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000695367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QOA01049.1"
                     /translation="MKIKTFATFTHRQLDKQVNRFLKNDIHVLEIQTHSNWLYISAIVF
                     YEDK"
                     /name="hypothetical protein"
     gene            complement(15120..15436)
                     /locus_tag="FPO35_14160"
                     /pseudo=""
     CDS             complement(15120..15436)
                     /locus_tag="FPO35_14160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002483623.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            complement(15429..16412)
                     /locus_tag="FPO35_14165"
     CDS             complement(15429..16412)
                     /locus_tag="FPO35_14165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="QOA01050.1"
                     /translation="MQNQYFTVQENYKERFYQIPKVFFTSENYKNLTNDMKIAYAILRD
                     RLNLSIKNSWVDEDGNIYFVYSNEKLMEILNCKKEKLTKIKKGLENDGLLIQKRRGLNK
                     PNILYLMKPIVTERDIYKIEKEENDVEPYGEKEVRKSNVQKFDFRTSRSSKIERPEVRK
                     SNTNDTDFNDIDFNDTENNDMNDLNDIKYKNEISNHSNHSNQFTHNFDDKEMLLQEFPE
                     QLTNYLLKYDYRDLEIIKAVILKAKKSFNSRHEDMHYMLEDIEDEILTSLKRLKKAIHD
                     RGVKGQKETIKSMQAYLMQTILTELEETHALYMRRKNMKQYNIFNQ"
                     /name="replication initiator protein A"
     gene            16807..17550
                     /locus_tag="FPO35_14170"
     CDS             16807..17550
                     /locus_tag="FPO35_14170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002508633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="QOA01051.1"
                     /translation="MKSVKKLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESTTEDKQKKGSDNINFESKSDAQIVEILKNQIDTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNTR
                     QNVDAQEKTYTTNPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAKKEDVPANLND
                     NDSDIEEKSEETEPKKGFWSRLFGS"
                     /name="DUF536 domain-containing protein"
     gene            complement(18019..18918)
                     /gene="mph(C)"
                     /locus_tag="FPO35_14175"
     ARG             complement(18023..18918)
                     /name="mph(C)"
                     /gene="mph(C)"
                     /gene_name="Mph(C) family macrolide 2'-phosphotransferase"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(19017..20483)
                     /gene="msr(A)"
                     /locus_tag="FPO35_14180"
     ARG             complement(19021..20483)
                     /name="msr(A)"
                     /gene="msr(A)"
                     /gene_name="ABC-F type ribosomal protection protein Msr(A)"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE/STREPTOGRAMIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            20957..21631
                     /locus_tag="FPO35_14185"
     CDS             20957..21631
                     /locus_tag="FPO35_14185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="QOA01054.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            21689..22066
                     /locus_tag="FPO35_14190"
                     /pseudo=""
     CDS             21689..22066
                     /locus_tag="FPO35_14190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000866106.1"
                     /note="incomplete; partial on complete genome; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /name="response regulator transcription factor"
     gene            22063..22944
                     /locus_tag="FPO35_14195"
                     /pseudo=""
     CDS             22063..22944
                     /locus_tag="FPO35_14195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_501406.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /name="HAMP domain-containing histidine kinase"
     gene            23060..23989
                     /locus_tag="FPO35_14200"
     CDS             23060..23989
                     /locus_tag="FPO35_14200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000074567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="QOA01057.1"
                     /translation="MKNLNNIIEINNLTKQYGSQIAVNNLSITVESGQIYGFLGRNGAG
                     KTTTIRMLLGLIKPTKGNIKIFEKEFESNKTEILKNIGAMVETPGFYSNLTAKENLTIN
                     AKILGIQKENAIEEVLEIVGLASEKVKLFKNYSLGMKQRLGIARALLHNPELLILDEPT
                     NGLDPIGIKEIRKLIKDLAQSRNITILISSHILSEIEQLVDKVGIIHNGVLLEEIMYED
                     LKKKNRQFISISVSDEEKVACLLETNFGIYDYKIKENGEFKIYSHIDRQQEINRLLVLN
                     NIDVFQMRVIEDNLETYFEDLVGGGTIG"
                     /name="ABC transporter ATP-binding protein"
     gene            23982..24719
                     /locus_tag="FPO35_14205"
     CDS             23982..24719
                     /locus_tag="FPO35_14205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000369394.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="QOA01055.1"
                     /translation="MDNLLRTEFIKLKRSYMFLISILGTCVAPFMVVVASFISMRTKVP
                     TPNIVFKQLFEEVSLYHMLIIGPPLYGVIIAYLFGREYIEDTLKNLLIIPISRESFLVS
                     KIILLFLWIQTLSVIAWLLTLMLGMLLHFQGLSQSLIIDSFFTFVIGGVLLWILSPPII
                     ILSIYFKNYVPTIVLTIIITLINLMTANSEHRGLFPWAAVGDISRGTLPNTYPFLLSLI
                     IIIVTSIFSVIILFSYFKKTDIS"
                     /name="ABC transporter permease"
     ARG             complement(19018..20483)
                     /name="msrA"
                     /gene="msrA"
                     /gene_name="msr-type ABC-F protein"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; streptogramin
                     antibiotic; streptogramin B antibiotic"
                     /identity="98.36"
                     /coverage="100.0"
     ARG             complement(18020..18918)
                     /name="mphC"
                     /gene="mphC"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="98.66"
                     /coverage="100.0"
     ARG             2103..2431
                     /name="APH(3')-IIIa"
                     /gene="APH(3')-IIIa"
                     /gene_name="APH(3')"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="98.39"
                     /coverage="41.29"
     ARG             1492..2009
                     /name="SAT-4"
                     /gene="SAT-4"
                     /gene_name="streptothricin acetyltransferase (SAT)"
                     /tool="rgi"
                     /drug_class="nucleoside antibiotic"
                     /identity="97.16"
                     /coverage="95.56"
     ARG             7868..8712
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="95.37"
                     /coverage="100.0"
     ARG             884..1185
                     /name="aad(6)"
                     /gene="aad(6)"
                     /gene_name="ANT(6)"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="99.0"
                     /coverage="36.23"
     Typing          complement(14917..15064)
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="5.980000000000001e-72"
     Typing          complement(15123..15298)
                     /name="rep_cluster_1017"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="92.697"
                     /coverage="94.0"
                     /evalue="1.04e-65"
     Typing          complement(15430..16412)
                     /name="rep_cluster_2100"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.289"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          16808..17550
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 aatataattt taacaaaaag gagtcttctg tatgaactat ttcagatata aacaatttaa
       61 caaggatgtt atcactgtag ccgttggcta ctatctaaga tatgcattga gctatcgtga
      121 tatatctgaa atattaagag aacgtggtgt aaacgttcat cattcaacga tctaccgttg
      181 ggttcaagaa tatgccccaa ttttatatca aatttggaag aaaaagcata aaaaagctta
      241 ttacaaatgg cgtattgatg agacgtatat caaaataaaa ggaaaatgga gctatttata
      301 tcgtgccatt gatacagagg gacatacatt agatatttgg ttgcgtaagc aacgagataa
      361 tcattcagca tatgcgttta tcaaacgtct cattaaacaa tttggtaagc ctcaaaaggt
      421 agttacagat caggcacctt caacgaaggc agcaatggct aaaataatta aagcttttaa
      481 acttaaacct gactgtcatt gtacatcgaa atatctgaat aacctcattg agcaagatca
      541 ccgtcatatt aaagtaagaa agacaagata tcaaagtatc aatacggcaa agaatacttt
      601 aaaaggtatt gaatgtattt acgctctata taaaaagaac cgtaggtctc ttcagatcta
      661 cggattttcc ccatgccacg aaattagcat catgctagca agttaaacga acactgacat
      721 gatatattag tgattagcta tattttttac tttgcaacag aaccatcatt tttattaaaa
      781 tactcttttg taaaatcttt ctgctcttca atgtatttaa tttctttacc tctaaatcta
      841 ttatagctat ttgatgatta caataaaatt gatcttacct tattgccctt ggaagagtta
      901 gataattacc taaagggcga taaattaata aaggttctaa ttgataaaga ttgtagaatt
      961 aaaagggaca tagttccgac tgatatagat tatcatgtaa gaaagccaag cgcaagggag
     1021 tatgatgatt gctgcaatga attttggaat gtaacacctt atgttattaa aggattgtgc
     1081 cgtaaggaaa ttttatttgc tattgatcat tttaatcaga ttgttcgcca tgagctgctg
     1141 agaatgatat catggaaggt cggcatcgaa acaggcttta aatgaagtgt aggcaagaac
     1201 tataagttta ttgaaaggta tatatccgag gatttgtggg agaaactttt gtccacctac
     1261 cggatggatt cctatgaaaa catatgggaa gcattatttc tatgccatca attgttcagg
     1321 gcggtatccg gtgaggtggc ggaaaggctt cattatgcct atccggagta tgataggaat
     1381 ataacaaaat ataccaggga catgtataaa aaatacactg gtaaaaccgg ctgcctggat
     1441 agcacatatg ccgctgatat agaagagagg cgggaacagt gattacagaa atgaaagcag
     1501 ggcacctgaa agatatcgat aaacccagcg aaccatttga ggtgataggt aagattatac
     1561 cgaggtatga aaacgagaat tggaccttta cagaattact ctatgaagcg ccatatttaa
     1621 aaagctacca agacgaagag gatgaagagg atgaggaggc agattgcctt gaatatattg
     1681 acaatactga taagataata tatctttact accaagacga taaatgcgtc ggaaaagtta
     1741 aactgcgaaa aaattggaac cggtacgctt atatagaaga tatcgccgta tgtaaggatt
     1801 tcagggggca aggcataggc agcgcgctta tcaatatatc tatagaatgg gcaaagcata
     1861 aaaacttgca tggactaatg cttgaaaccc aggacaataa ccttatagct tgtaaattct
     1921 atcataattg tggtttcaaa atcggctccg tcgatactat gttatacgcc aactttgaaa
     1981 aagctgtttt ctggtattta aggttttaga atgcaaggaa cagtgaattg gagttcgtct
     2041 tgttataatt agcttcttgg ggtatcttta aatactgtag aaaagaggaa ggaaataata
     2101 aatggctaaa atgagaatat caccggaatt gaaaaaactg atcgaaaaat accgctgcgt
     2161 aaaagatacg gaaggaatgt ctcctgctaa ggtatataag ctggtgggag aaaatgaaaa
     2221 cctatattta aaaatgacgg acagccggta taaagggacc acctatgatg tggaacggga
     2281 aaaggagtgg tatgacattg ccttctgcgt ccggtcgatc agggaggata tcggggaaga
     2341 acagtatgtc gagctatttt ttgacttact ggggatcaag cctgattggg agaaaataaa
     2401 atattatatt ttactggatg aattgtttta gtacctagat ttagatgtct aaaaagcttt
     2461 aactacaagc tttttagaca tctaatcttt tctgaagtac atccgcaact gtccatactc
     2521 tgatgtttta tatcttttct aaaagttcgc tagatagagt tctatattag agatgtaaag
     2581 agttttggtg aagaggtttg tgagtatggc ttttataacc agggtgcaat gagaagcact
     2641 aacagcagct agcttaagaa cgcataggat atacttttta tggaagtcac agaggaggaa
     2701 taaaatttga acaggattaa cagagtaacc tctattctta ttcagctgca atcaaaaaaa
     2761 taattcctgc caaagaaatt gcacagcgat ttaatataag cttaaggaca gtttacagag
     2821 atatccggac acttgaagaa gccggaatac caattggatc tgaggccgga aaaggatatt
     2881 ttcttgtaga gggcttccta cttccgccgg taatgtttac agcggcggaa gtgggtgcat
     2941 tgattacagc agggaaattt ttaaattgcc atggagatga atcatttata aaggattttg
     3001 attcagctat gtataaaatc aaatctattt tgaagcatgg tgaaaaaaac tatgcacagg
     3061 agttggagaa cagtattaac gtgtacagca catctggaca gaaaaataca ttggcggata
     3121 acgttattgc agcaattcag actgcaatct gcaataaaag ggtaatatca attcaatatc
     3181 ctgcatcagg agggcaagaa ccggaaagca gaatgataga gcctatatca ctggggtttt
     3241 atgaacagaa ctggtactta atcggttttg caggctaaga aatgaatata ggaattttcg
     3301 tgtggatcgg attaaaagca tttgcataga agaagagctc tgtcaaagcc atgatggctc
     3361 tttggaacaa atattaaaac aaatgctggt tctgttgcaa agtaaaaaaa tatagctaac
     3421 cactaattta tcatgtcagt gttcgcttaa cttgctagca tgatgctaat ttcgtggcat
     3481 ggcgaaaatc cgtagatctg aagagacctg cggttctttt tatatagagc gtaaatacac
     3541 tcaatacctt ttaaagtatt ctttgctgta ttgatacttt gataccttgt ctttcttact
     3601 ttaatatgac ggtgatcttg ctcaatgagg ttattcagat atttcgatgt acaatggcag
     3661 tcaggtttaa gtttaaaagc tttaattact ttaaccattg ctaccttcgt tgaaggtgcc
     3721 tgatctgtaa ttaccttttg aggtttacca aattgtttaa tgagacgttt gataaacgca
     3781 tatgctgaat gattatctcg ttgcttacgc aaccaaatat ctaatgtatg tccctctgca
     3841 tcaatggcac gatataaata gctccatttt ccttttattt tgatgtacgt ctcatcaata
     3901 cgccatttgt aataagcttt tttatgcttt ttcttccaaa tttgatataa aattggggca
     3961 tattcttgaa cccaacggta gaccgttgaa tgatgaacgt ttacaccacg ttcccttaat
     4021 atttcagata tatcacgata actcaatgca tatcttagat agtagccaac agctacagtg
     4081 ataacatcct tgttaaattg tttatatctg aaatagttca tacagaagac tcctttttgt
     4141 taaaattata ctataaattc aactttgcaa cagaacctca tttactatat gggcatctct
     4201 ttcattatta atacaaagct ttgtatctcc gatattaggc aaaggtgtaa acgaattagg
     4261 tgatactata ggattcaaca ttatattaat cgtttcttta ataatgatta tcttcttatt
     4321 ttttataaat cgtagtaaaa atatctccta tgattatata aaagttcaaa gaggtgaagc
     4381 caatgaataa attagaaaaa tggtctttgg tatttattat ttttacattt ctctcttcat
     4441 tagcactttt atatttcaaa tataatttta gttcggttat gccagtccta agtctttcta
     4501 ttttaactat actaatattg ttgacgagta ttattactgt agtttcagtt aatgatgaag
     4561 atacttaaaa cgttcattag tgaaacaggt attatattaa aaaagcgtac gaatttgtac
     4621 gcttttttct tgtgttatta ttaaaatctc ataacaggaa aatattatga gattttagac
     4681 gctgtcagaa cgtctctttt acatcgagtg acattgaatc aaagtctttg tatgttaatg
     4741 atatataaaa ttatttagta gattcattat agtaagctag attagttgct ctacttgttt
     4801 ttattctctt ttgcctctaa tttattgaga taacgataaa tagttgtacg tgaaacttgc
     4861 cactgctctg caattgtttt aattggcgta ccattatcat aaagtgtctt aagtaagttt
     4921 aaatcttgtt tatttaattt ttcaggtcta cctccatatc ggcctctagc acgtgctgca
     4981 attcgaccgg ctgatgatcg ctctaaaatt aaattacgtt caaactctgc aaatgctgcg
     5041 aataaatgaa ataataattg tcctgtagaa cttgatttat ccatcgttat attttcttct
     5101 aaactatgaa aactcacacc tcgttcgtta agttcattaa ctaacgtgat taaatcctcc
     5161 atgttccgtc ctagtctatc taatctccaa acaacaatcg tatctcctga cctcgcaaat
     5221 tcaattgctt tatctaaacc aggtcgctta ctttttgaac cactcatatg gtcattaaat
     5281 atcttttcac aaccatatgt atttaatcga tcctcctgta aattcaaatt ttgtaatcca
     5341 gttgaaactc ttgcataacc tattttcaaa atacagacct cctatataca cctttagtgt
     5401 accataactt gattacgagg tcttttgtga acatagattt tttgttgggt ttttgaacac
     5461 ataattctat gtaatacata cttatttaga cataaaaaga gagtgtacag aaaatggtta
     5521 ttttatgtac actctcatct ttactaatat attttaaatg ttattaacaa aactaattta
     5581 ataagagtca agtatagttt acatatgtat aatgtttgaa acatatctct aattactttt
     5641 tactaatatc atttaaaatg tctcgcaatt cttcaatttc tttgttattt aattcttcat
     5701 ttttcgcaaa atttagcact aaacttttca tgtcccctcc atacagttta ttaagaaaag
     5761 ttttagcagt tttcatttta atatcgtctt ctttaatatt tgatgagtaa aaataaatat
     5821 tctctgattt gtatcgtttt ataatctctt ttttatatag tcttgtgatt aatgttctaa
     5881 ttgttttatc gctaacttct ttatattttt gaatttcaac tacaatttca ttagctgata
     5941 ctgatttttt atcccatatt atattcataa catcccattc agccatagat atttcaactt
     6001 gcttattggc catttaaaac acccatttct tttaatattt tttcactgat taattcagca
     6061 tttttcccag acgggtttcc atctgataaa tgtgtagcaa aataatactt atcatgattt
     6121 gtaattacgt aacctacaaa ccacccatta ttatacttcc cgtttactat acctgtacct
     6181 gttttcccat acagttcata cttttcattt ttcttaatca ataatgaaga agataattga
     6241 ttctttgctt ttttactaaa atggttattt tgttccatca tatttttaaa aactattact
     6301 tgttcaagat tagatatttt caaactatct tccatccaat agtttttata acttcccaaa
     6361 ttttcattac cataatttaa ttgcttgagt tgagccgcag tatagttctt tggtatttga
     6421 ttactaatac gttcgaagta ccaattaact gaattttgca ttgctgtatt taaatcttgt
     6481 tccttattcc aagactcgaa aggataatgt ttatgattcc atgacatacg tgaattttta
     6541 tcacttatga tatgacggtc aagtccaaac atcgctaaat aaattttata agttgaatca
     6601 ggagaatatc tttttctact ttctttttca ttataaatat agtatttgtc tttcttcatg
     6661 ctgtacatga cgaaagatcc actatttgaa ccaaaatttt tactttcatc taaaatttgg
     6721 tgatcgttct gtaagggctt tttataatta taatcagtta tggattgccc catcaaaaac
     6781 tggctttgaa ttactatgag caaaaaagta aaaatacaaa taaaaattgg aattaattta
     6841 gactgttttt tcaaattggc ttcttttata ttaattaatc ttcttttgag taatgacttt
     6901 ttaccattaa atgaatggct taatatattt ttattaaaaa atggaatatt taatacggag
     6961 tccataatag attccgcata agttttaaat tcatttttgt taatattatt aagaacaaat
     7021 ctatcagctt ctacttcatt gtcatgaatt atctttcttt ttacaatatg tattaatgga
     7081 ttgtaactca taacaataga gaagatatta aagataatta aatgtaaagt atctctattt
     7141 ttagcatgag catattcatg cagtattata tattttagtc ttttatcaat tacactttta
     7201 aaatatgaac taggaatcaa aataatatat ttcccatacc aaaaagttat tggagattga
     7261 atagcctctg cttttcgaat cacaatattt tttttatatt gatggttgaa aagtatcgta
     7321 tctattttat ttttttcatt ttcgtttaga taaagtgact gtttctttaa atatttaaga
     7381 tataataagg ctttcaaaaa tttaaaactt aaaataataa ctaaaactat ccaaataact
     7441 gtgcagatat tatcaattga atcccaatta aacttatgga tatctgttgt gaactcttga
     7501 ataggtttgg tggtatttat gttatggttc aaatcgtgtg acttactttc aactgtgggc
     7561 gcttgattat tcacattatt aaattttata aaagagaatt taattgggat aaaaggaatt
     7621 aatccagcaa gcatagttag ataccaaact ttataattta aactataatt aaaatagcgt
     7681 tttaatatgt acctaaaaaa tactaacaat agaaatataa aacaaaagct tactacgctc
     7741 attattagta atttagccat tttgacacct tctttcaaat atttataata aacaattgac
     7801 atcaatatta caattgtaat attattgatt tataaaaatt acaactgtaa tatcggaggg
     7861 tttattttga aaaagttaat atttttaatt gtaattgctt tagttttaag tgcatgtaat
     7921 tcaaacagtt cacatgccaa agagttaaat gatttagaaa aaaaatataa tgctcatatt
     7981 ggtgtttatg ctttagatac taaaagtggt aaggaagtaa aatttaattc agataagaga
     8041 tttgcctatg cttcgacttc aaaagcgata aatagtgcta ttttgttaga acaagtacct
     8101 tataataagt taaataaaaa aatacatatt aacaaagatg atatagttgc ttattctcct
     8161 attttagaaa aatatgtagg aaaagatatc actttaaaag aacttattga ggcttcaatg
     8221 gcatatagtg ataatacagc aaacaataaa attataaaag agatcggtgg gatcaaaaaa
     8281 gttaaacaac gtctaaaagg actaggagat aaagtaacaa atccagttag atatgagata
     8341 gaattaaatt attattcacc aaagagcaaa aaagatactt caacacctgc tgctttcggt
     8401 aagactttaa ataaacttat cgcaaatgga aaattaagca aagaaaacaa aaaattctta
     8461 cttgatttaa tgttaaataa taaaagcgga gatactttaa ttaaagacgg tgtttcaaaa
     8521 gactgtaagg ttgctgataa aagtggtcaa gcaataacat atgcttctag aaatgatgtt
     8581 gcttttgttt atcctaaggg ccaatctgaa cctattgttt tagtcatttt tacgaataaa
     8641 gacaataaaa gtgataagcc aaatgataag ttgataagtg aaaccgccaa gagtgtaatg
     8701 aaggaatttt aatattctaa atgcataata aatactgata tcatcttata gtttgtatta
     8761 tcgttgacat gtataatttt gatatcaaaa actgattttc cctctattat tttcgatatt
     8821 tattttctta attctcttta acaaactaga aatattgtat atacaaaaaa tcataaataa
     8881 tagatgaata gtttaattat aggtattcat caatcgaaaa agcaacgtat cttatttaaa
     8941 gtgcgttgct tttttctcat ttataaggtt aaataattct catatatcaa gcaaagtgac
     9001 aatagcattt tacaagtatt ttttattgtt cgattagggt aaacctaaat aatacataaa
     9061 ttatattaca atatgtttat tatagaggct aaagtatctt agaaatttgg atagtaggtt
     9121 tttcgggaat aaaagtatag ttggctttaa tatataatta agctaagcta tcatttatat
     9181 ttactcgatt ataattcgca cttcaacttt tttataacgt aaaaattaaa acgtagtttt
     9241 atttatcttt agtaatatct ttttaaacac tacagtttct tcattagtta aattagcgaa
     9301 gtaatgatta ttaagttgat aggctttctt ttctaatgtt ggccataagt cttttgcttt
     9361 atttgtactg tttattagca cagttcttct attttcatta tcagtttgac gtgttattag
     9421 atcctttttg gacatcttat ctaatattcc agatattgtt gaaggttcta aatttaaagt
     9481 attaccaatc gctttaggtg tattcaaatt actattaatc aagcaattca aaacaccata
     9541 ttctgctgga gtaatattat agggacttaa taaactttta aaatgtttaa aaactctatt
     9601 ctgagaagta ctcaacaaat aatttataca attatctaat tccacaacta aaacctctct
     9661 taaatcatta gtattgactc gcttatcata tcatgataag ttttgtagga aaatagtttt
     9721 gcaacaaaaa catacttcta caaaacaatt gtgaaagaag gctaataaat gttcaatgcg
     9781 gtagtagtga gaaaaagtgc atcaaatgtt agttataaag tagaaaaagt tgatgaatct
     9841 catttatcga agggtgatgt attagtaaaa gtggtatact cttcaataaa ttataaggat
     9901 atgctagctt tacaatataa aggcggtgta attagagatt atcctatgat tcctggtata
     9961 gattttgcag gtattgttga atcaagttcg aatgataagt ttaaagaagg cgataatgta
    10021 ttagttactg gttatgatgt tggcgtgaca catacaggtg gattttcaga atatgcacaa
    10081 gtgcctggag agtggattgt tcctattccc caagaaatgt ctattaaaga gtctatggta
    10141 tatggcacag ccggttttac ggcagcatta tcaatttttg aactagaaaa atatggaatg
    10201 aatatcaaat cacaacctga aattttagtg tctggggcta caggtggtgt gggcagtgtt
    10261 gctatacaaa ttttacataa aattggatat gaaaatatca ctgctatcgt aagaaaagaa
    10321 aagcaaatag aaatcgcaaa aaaattaggt gcaaaacaag taataataat tgaagatgat
    10381 aataaaccgc ttaaaaaagg tatttttgat tatttcttag atacagtggg gagtaatgta
    10441 acattatacg gtttaaaacg tctaaattat caaggtgttg ctactgtatg tggaaatgta
    10501 gcaggaaatt cacttaacgc taatatatta ccgtttattc ttagaggtat taaattaatt
    10561 ggcattgatt ctgtatatgt tgatcataat atccgtgaag atatatggag taagttagca
    10621 aatgaatgga atataggaaa ttcacttcta tacaatgaaa ttggatttga agaattctat
    10681 aaaacgatag atcagctttt aaaaggacaa catttaggaa gaactatttt aaaagtataa
    10741 gtgtgagtat tcattaatac atttactatt aattcaatca ttttgcattt ctctactaac
    10801 cagtgttata atttatataa cgaaaatgat taacaattaa tgcaccaatc cccacactat
    10861 tgcagtagtg tggggatttt ttcgatgctg gcttataaag tcgcctatta attatttgtt
    10921 gcgtttacta agccaataag tataatacgc aacagcacag ccactgatga ctggtgctat
    10981 gatgtgaacg aaaatgatta gcaaagtaat gcacctcctc tcttcgtcaa ttgacgcctg
    11041 agagataggc gactctatta ttataccatc tgtgaatata caagcatatc tacttccgat
    11101 aagtcgtctt atgttatata actttgtttt ttatagtatc aagacaagaa gaaactcgtt
    11161 tcaaaaaccc tcatgatttt tagagaaaaa ctctcttatt tcatcgtctt taataaaata
    11221 atatgccatc tttccatctt tataaaaatc aagtacctca tttttatata aaagccttaa
    11281 atgatgtgaa gttgaagcaa cactcatttt caatatcaaa gaaatatcac aaacacacaa
    11341 ctcatcttct ttaatcaaag ataatatgat tttcaatttc ttctcatcac aaattttttc
    11401 taaaatgtta agtaatttct tagatttatc atcttctaaa aaacttaaag cattgttaac
    11461 tttatcctca tgtacacaga tcacatcaca agtattttca taactcatat aaaatcacac
    11521 cctaaattaa aatataaatc ctaaaattgt ttgaatagtg tcattttcaa taataataaa
    11581 taaacctaaa gctatataaa taatagccat aatccaacga ctaaatttct caacaatttc
    11641 tccaattcct ggaatattag ctaatttttg tgcagtaaac accaagaaga aaattaaaat
    11701 taaaaagaca aacagagtaa gtaataaatt agtaacactt aatgtcacaa aatacggaac
    11761 aaataaacca atattatcgg cgccacaact tgctatcgta acaattgcaa ccgtaccaac
    11821 taatttagac aatccttttt cattcaattc ttttttagct ctcttttctc cttcacaatc
    11881 atcataaata gccactttaa ttccaagata aattggtatt aaacccaata aacctaatat
    11941 ccacttttct ggaacataat ttaatacaaa agctaaaaac aaactaacta atattaaaat
    12001 aatagaccct aaatattgac caacataaat atctctatat tcttttctag tctttgctct
    12061 agcaaaaaat attaataaaa ttactaataa atcaactgct gtagcaatat aaagaacagc
    12121 agcagcaaca accgtttgaa tcataataca cctcattcaa aaatattttt gaatgtatta
    12181 taacttatat ttttaaataa tcataggtgc tttattccaa ttgctttatt gacgttgagc
    12241 ctcggaaccc ttaacaatcc caaaacttgt cgaatggtcg gcttaatagc tcacgctatg
    12301 ccgacattcg tctgcaagtt tagttaaggg ttcttctcaa catcaataaa ttttttcggc
    12361 ataaatgcgt gtctatgcgt agacatggag acacttcaga attatggagt gattacatga
    12421 gtttaactat ttttctttat tcagttttag gaagtttatt agcaaattat atctacgaaa
    12481 aatcttcaaa ataaataact ttttcggttc tattttgtac actttatcta cctggtagac
    12541 ctaattgtta ttgctttaca ggtctaaaat tcgtcgttat aatctagtta aatcccgtaa
    12601 gggcgcactt atacgtcgga taaatcgaca tgtgcaaaaa cgtaatcgac cttcgtcgat
    12661 ttttttattt caaaattaaa gaaacggctt gagatattcc gagcagttat aaaaattaat
    12721 ttgcgttgaa tattgctact acattcttga aaaagtgatg tagatttata gcccataact
    12781 tttttgaatt acatcgacga tacggcgtcg aaagaaaaat aaatagaccg tatgaaagaa
    12841 aaagctacct cactttatct ggggtagctt ttatttttta tgcccttatt ttgaatttta
    12901 agagggcatt ttaaagattt aggggtgatt catatagttt tatatctaaa acttatatat
    12961 gcttttaaaa cgcaaatatg agccaaataa atatatgcta ttttcaaaaa caaaaatttg
    13021 agcaaaaaca ataactattt ttagacactg cccatttaca tgcaaattaa aaattagcat
    13081 aaaattcttt aaaacttccc cacgtttttc taaattcctg tagggcgttt ttatcaaaaa
    13141 tcaagacaag aagaaactcg ttcacactcg tttcaaaaaa acaagaaatc taatctatac
    13201 acctaccgtt ttccaacccc ctcaaagcat acaaattaaa aacaaaatta ttcataatct
    13261 tactttcttt taacaaaaac ataaaaacca taaatagaca aattaactat caaaggcaat
    13321 aaacagtata aaaaaaccac gaataaatct tcatcaacat ctaaaataaa aaagaataaa
    13381 acaattaaca aaatactaat taacaaacct aaaagtggca aactttttat atatttttct
    13441 aaattttcat tcataaaata gactcctttc aaaaatatgt ttataaatat attaaaataa
    13501 atattgattt tataaagcgc ttacttatac aattaaaata tcttattatc ttggaggtat
    13561 caaatgaaaa ttataaaatt attttcaata atttccttgt tcctactggt atttagcgcg
    13621 aatttttcta atgcttacgc aaatgaagaa caaaaaagtt ctttactaga aaatcaaaaa
    13681 gaaaaattga aaagcaaaaa catcgaagta tcacaaatga ccaagaaaga aataagtttt
    13741 ctagaacaat tgcaaaataa aaatgaagat atgcaaaaat tcgaaaagca aatgaaaaaa
    13801 gaaggattta aaaaaataaa gctagaagac aaaaattcta aattaaaata tctagctaca
    13861 gaagcaaatg ataaaaatgc atatggctac atagctaata acgcttataa aaatgaaaaa
    13921 acaaaagaaa ttgtagtttc tgaaacaata tatgataact acaacaaaaa aatcacaaaa
    13981 ttcattgccg aaaaaagaag tatgactgaa aacaaagagg gaaaaatact tattaacaaa
    14041 aattacgttg aatataaggc tgaaaaagtt gataaaaaca gaccggtaac atatgcagga
    14101 ttcaaatgga acggcaaagc attcgcttgt agtatggctg gactttatgc atgtgctcac
    14161 tactgtggag tatgggcaat cgtaaatcca atagccggcg gtgtatgtga agcagtttgc
    14221 ggaactgcat ttgcagctgg atgctctgta ggttgatttt attccaattg ttttattgac
    14281 gttgagcctc ggaaccctta acaatcccaa aacttgtcga atggtcggct taatagctca
    14341 cgctatgccg acattcgtct gcaagtttag ttaagggttc ttctcaacat caataaattt
    14401 tttcggcata aatacgatgt tccttattta tcctcataaa aaacaatagc tgaaatatat
    14461 aaccaattac tgtgtgtttg aatttctaat acatgaatat cattctttaa aaacctatta
    14521 acttgtttat ctaattgacg atgagtaaaa gtagcgaaag ttttaatctt catgatatct
    14581 ctccttttat aaaaatagca atccttatta caatattaaa cacttttatt ttggatttta
    14641 agaggcattt tgaagactta gaggcaaatc atataggttt tgtacttaaa aatctataca
    14701 gtctcttaaa acgcaaatat gagccaaata aatatatgct aatttcacaa acaaaaattt
    14761 cagcaaaatc agtgactaat tttttagata ctgcccattt acatgcaaat ttaaaaatta
    14821 gcataaaata ctttaaaact tccccatgtt tttctaaatt cctgcagggc ttttcttatc
    14881 aaaaacttag aaattttaat ttaactctaa aatctccgta agagcataag ggaaatttgc
    14941 tatcattcaa aaatgataga tctggcaagg ccagacattc caagggtttt aagttatttt
    15001 aaagtgatat catacaaagc tgtagtgtca cacttttgtg acactacata cagcatttgt
    15061 cacaaaaata agacagcact tttttacaga aaaacaataa aaaaagacat cagttatcac
    15121 taatgtctta aataataatt ttgcttttcg aaattccaaa ttgcggtaat tgaatgtgct
    15181 ttttttcttc gtctgtcgtt ttatcttcat cacttgtatt aatcaaatta ccatcttcgg
    15241 catcgtctaa gtttaaaatt ttatgctttt gtttaagcaa tccaccataa cttaacatac
    15301 gttttcgata caaacctttt tctaaatcac ttacaatttc ttgatttttt tcgtcgtcat
    15361 cagttaaaaa gtcagatgat ttaacggaat attttgatgt ctcttcgagt gttataaaat
    15421 catttgaatt attgattaaa gatattatat tgtttcatgt ttttacggcg catataaagg
    15481 gcatgtgttt cttcaagttc agttagaatt gtttgcatta aataagcttg cattgacttg
    15541 attgtttcct tttggccttt aactccccta tcatgtatag cttttttaag tctttttaaa
    15601 gaagttaata tttcatcctc aatgtcctct aacatgtaat gcatatcttc atgccttgaa
    15661 ttaaatgatt tttttgcttt aagaataaca gcctttatga tttctaaatc tctataatca
    15721 tattttaata aataattagt tagttgttct gggaattctt gcaatagcat ttctttatca
    15781 tcaaaattat gtgtaaattg atttgaatga tttgaatgat tactaatttc atttttgtac
    15841 tttatatcat tcaagtcatt catatcatta ttctcagtat cattaaagtc aatgtcatta
    15901 aagtcagtat cattagtgtt cgattttcga acttctggac gttcgatttt cgaacttctg
    15961 gacgttcgaa aatcgaactt ctggacgttc gattttcgaa cttccttctc gccgtaaggt
    16021 tcaacatcgt tttcttcttt ttctattttg taaatatcac gttctgtgac aataggtttc
    16081 attaaatata gaatatttgg tttatttaaa ccacgtcgtt tttgaatgag tagaccatcg
    16141 ttttctaacc ctttttttat ttttgttaac ttttcttttt tacaatttaa gatttccatt
    16201 agcttttcat ttgaataaac aaagtaaatg ttaccatctt catcaaccca gctattttta
    16261 atagataaat ttaagcgatc acgtaagata gcataggcta ttttcatatc attagttaga
    16321 tttttataat tttcactggt aaagaatact ttagggattt gataaaatct ttctttgtaa
    16381 ttttcttgca ctgtaaaata ttgattttgc atgacaaaaa acctctttcc atattttagt
    16441 ttggtaagag gtaataaaac gtttttattt agctttacat ttatttaatg atttaggtgc
    16501 ttgcactaag atattattca ttatataata caagtatcga aaattatata aataaacagt
    16561 ttctaaacgt tttattacca aaccccgact attaccagta gttggggttt ttgttatatt
    16621 aagtttatta tagcacttta aataaactta taaaagggaa aatatagctt tatcaagggt
    16681 ttataaaccc ttgataaaaa ggttgatgga tgtttatttt tatttattaa tcactttatt
    16741 attaagcatt ataagcttat aatattttat caagggttta taaacatttt ataaagggtt
    16801 gatgatatga aaagtgtgaa aaagttgagt gaagaattag gggttagtaa gcaaacgatt
    16861 tttaataata ttaagcgatt gaatatagag acaataaaac aggaaaacac ttcgtttatt
    16921 aaagaagata ccgatataga aaaaatcatt caaagagtaa atgaaaataa aaagaaatat
    16981 ggttttgaaa gtactactga agacaaacaa aaaaaagggt cggataatat taattttgaa
    17041 tcgaaaagcg atgctcaaat agtagaaatc cttaaaaatc agattgatac tttaaataat
    17101 caaattgaaa aacaagaaag tcgtcatgaa acaacaattg aattttacag aaaagagttg
    17161 caagaaagat caaaattgct tgaaaatcag caagttctgg cattagagag taataaaaag
    17221 attcaaaaat tagaaaatca attagaaaaa gaaaaacacc ttaattatcc ctttgataca
    17281 tctactaaca ctagacaaaa cgttgatgca caagaaaaaa catatactac taatcctgta
    17341 aatattaaca gagatcagga agaaactaaa gaaacagaga ttcaatataa ggatatatct
    17401 ggaagtcaaa gcgacgaaag tacacaaggt gaagaagcaa aaaaagaaga cgttccagct
    17461 aatctaaatg acaatgatag tgatatagaa gaaaagagtg aagaaacgga acctaaaaag
    17521 gggttttgga gtcgtttgtt tggtagctaa aataattgat taggcactaa aagttataaa
    17581 attttagtgt cttttatata gtgagaactt ctggtaatca tcgattatgt aaactaaagt
    17641 atttcaaata attaactgta ttaatactct catcatgatt gcgttataaa cgttcatttg
    17701 aaggtcatct ctatcataaa tatttaaatt aactaaaaat tttaatcatc tgtttaatac
    17761 ttatgaaatg tatttacggt aggtattaaa attgatgaaa tttatataag tgctttcaat
    17821 gaaaatgacc gtttatttat cctcctgatt taaggagtta gaaatttcga aaacgattct
    17881 ttccatttgt tgcatttgtt ccatgtccag atatttaata cattatagaa aaccaaagac
    17941 catcactaat taaacgcagt tttaaaattt catcaggatt gccttcgtct ttaaaatggg
    18001 cctcttttaa tataagttct actctttcat acctaactct ttcaatgcca tcgtttcata
    18061 cgccgattct cctgattcca tagcaaactc agcgataaac attgggaata ctgcattgag
    18121 ttctattata tgctctttca ttcgtggcca tatttcacct ccagctttac cgtatgctgt
    18181 tataagttgc tctaatcctt cgtcgtcgaa tacacgatgg tgtcctataa agtccattga
    18241 tgggtcggag tgggttgctt cagtccagtc tatgagacct gtgacgtttg cttggttatc
    18301 taccattata tgtcctggat gtaagtcccc atgtatcatg gtcgcatgtc gaggccatag
    18361 ttcgtcgttt tctaaccatt gtttccatct gttccataat tcatctgata cgccataagt
    18421 ttctttaact ttattcattc ttctttgaaa gtcatttttt atttcttgta tggttttgat
    18481 atttatatgc tgaacgttaa tgttttcttc tggtatgttg tgtaaatcta cgagtgtttc
    18541 agctaatgtg ttaataaagt tttctggtaa tggtttgtgt tcaatttccc atacataatt
    18601 ttgtatttct ggatctattg tggctgcggg tttacctgta agttttgggt aagcaataag
    18661 gtcttttgca tgtactttcc acttcggtat ttcaaatgaa acattcttct gtaagaagtc
    18721 taccgtttgt ttttcgggtt ttgttcgttt ataaacgtca ggtcttcttg gtagtctcaa
    18781 aacccattct actccatgtt tatcttttcc aaatgcaact tgaaaatcaa gtcccgattc
    18841 attcaatgag attgtttgag gttggatgtg taattgatat ttttctgcac atttaataat
    18901 ttcattatgt cgagtcattt tattggatcc ttatttctat tatatttttc ttgtgaacgt
    18961 attttttata ttgatataaa tgaacctaat attcaatata aattagtgta tagtttttaa
    19021 gttatatcat gaagagattg tcctgttaat tcccattttt tatctgatac atgtttaaca
    19081 aaccttgtat catgtgatgt aaacaaaatg attccaggat atttattcat aaacatttct
    19141 aatgcttcta atgttttaat atctaaaaaa ttagttggtt catccaaaat taacatattc
    19201 gctttcgttg aaaataatac tgctaacgat aatttcgttc tttccccacc actcaaaaca
    19261 ttacaagaac gatcaagtgc ttcatttaaa cccaagttat ttaaaatagc tctactgaat
    19321 gattctgatg aatccgtttc atccattaaa tattgcaata atgaaacgtc acgcatgtct
    19381 tcataagcaa gttgacgata gtatgccatt tgcactttag gagaacaatc aattccctct
    19441 atttggtggt aaatagcttc aagtaaagtt gtcttaccta caccatttgc acctacgagc
    19501 gctatatttt tgccatatgg tatttggaat cgtacttgtg ttagcagttt ttgacttcct
    19561 ttaaccaatg ttagattttg tgcaatgatt ggataattat tatggatatc ataaatttta
    19621 ttttgtggga aattgaattc atgataactt tgtggttttt caacttcttc caaatgttcc
    19681 attctttttt caatatgctt agcttgtttt tgagcagcct tctcaaccgt gcctttttgt
    19741 tttgatgcac ttaaacgatc tggtgctata cttttgtttt tttgttttga tgatgcttgt
    19801 gccatttgtt gcgcttgatt tcgtttagct ttactggctt gggacaatct ttgtttttca
    19861 cttatatact gttcatattg acgttgttgt tctaactgtt cttgttcata ttgattttga
    19921 tactgtgtgt aattaccttt aaacactctt attgtgccat cttcttgtat atcccaaatt
    19981 gtgtcagcaa tttggtctat aagtgctcta tcatgactta ctataattaa agtaccatag
    20041 taatatttta aaatattttt cagataatct ttaccaattt tatccaagtg atttgtaggt
    20101 tcatctaaaa gtaatatcgg actataattt gatatgacat tagctaattt atattttgct
    20161 ttttcaccac cactcatact gtcggttgta tgcataggta tatggagttc actcattaaa
    20221 ctaccgtcta acgtgttaaa atcattttcc acatccatgt taagctgttc aaaatattga
    20281 atttcgccaa ccgtttcaac tgttccagat tctggttttg ttttttgagc aatcatattt
    20341 agtaatgtgg ttttgccagt accattaccc ccaataagtg ctattttttc aaattggtaa
    20401 gcgtaaagat gaccgatgtt aagtgatcgt aaatctgtca atttatgatt gatttggtta
    20461 aatttaattg tatattgttc catatttata cactccttgt atatttaaag gacgtgtacg
    20521 caaaaaaatg agacaggcta ctcccgtctc attcacatta cactttcaaa cacttaaaaa
    20581 tttattatga tgttttagta tttgaaagcg tttattattc ctatcgaagg ataaaaaatg
    20641 acataagtca tcctatgagt gtgtattgcg gacaagcctt tttgaattaa tttagttttg
    20701 tattcaaaaa ggtttatttg agtctcatag aagctgtcat tttaatcctc cttcatcgat
    20761 aaaatagtaa tgttaatata acattttgtt ggttttttta caatatatct ctaagtagaa
    20821 agattatata acaaaagtat aaaaatacaa ttttagattg attatacatc tccttaattt
    20881 agagtgtact cataaaatac ggttctgttg caaagttgaa tttataatat aattttaaca
    20941 aaaaggagtc ttctgtatga actatttcag atataaacaa tttaacaagg atgttatcac
    21001 tgtagccgtt ggctactatc taagatatgc attgagctat cgtgatatat ctgaaatatt
    21061 aagagaacgt ggtgtaaacg ttcatcattc aacgatctac cgttgggttc aagaatatgc
    21121 cccaatttta tatcaaattt ggaagaaaaa gcataaaaaa gcttattaca aatggcgtat
    21181 tgatgagacg tatatcaaaa taaaaggaaa atggagctat ttatatcgtg ccattgatac
    21241 agagggacat acattagata tttggttgcg taagcaacga gataatcatt cagcatatgc
    21301 gtttatcaaa cgtctcatta aacaatttgg taagcctcaa aaggtagtta cagatcaggc
    21361 accttcaacg aaggcagcaa tggctaaaat aattaaagct tttaaactta aacctgactg
    21421 tcattgtaca tcgaaatatc tgaataacct cattgagcaa gatcaccgtc atattaaagt
    21481 aagaaagaca agatatcaaa gtatcaatac ggcaaagaat actttaaaag gtattgaatg
    21541 tatttacgct ctatataaaa agaaccgtag gtctcttcag atctacggat tttccccatg
    21601 ccacgaaatt agcatcatgc tagcaagtta aacgaacact gacatgatat attagtgatt
    21661 agctatattt tttactttgc aacagaacca gccatttaat atgactgtta caattactaa
    21721 gattcaagca ctattacgcc gcacgtatga tttcaccact caagttaata atttaacagt
    21781 agatgattgc gagttactac ttgatgcagc aaagcttaaa tttaatgaag aaaccataga
    21841 cctgacacac actgaattgc aaatcatgca tagcttattc cagaacaagg gcaaattcgt
    21901 cagtcgtaat gcgttaatcg aaaaatgctg ggaatcagaa cacttcattg atgacaatac
    21961 gcttgctgtc aacattacac gtttacgcaa aaagctacaa aaactaggac ttacagattt
    22021 tatcgaaacg aagaaaaatg tcggatatcg tgtaggtgac gtatgaattt cttgaaatca
    22081 atccaacgtg aaatttatat tgtcatcctt acttgtgctt tattctactt tatattattc
    22141 atgtataatg tgccgatgca agcatatatg attggtctag gtattgtatt gtttgtttca
    22201 atgatttact ggggtatcca ttacatgaac tttaaaaaag aataaacact acaggaacag
    22261 aacgaagatt taagaatcga aaaccataaa cttcgtaatg actttattaa ctaccaaagt
    22321 gagttagagt catatttttt aatgtgggtg catcaaatca agacaccgat tacagcatca
    22381 aagttactgc ttgaagatcc tgatgaacac gtgatttcta acgtgcgtaa tgaagtctta
    22441 caaattgata attacacgaa tcttgcactg aactatttga aactcatgaa ccaaaagaca
    22501 tacatggtct ttatggaagt gagtgtagat gaattaattc gaccactgat taaacgttat
    22561 gcgatacagt ttattcatca tcaaacaaag ttgcattatg agaaaagtga agcggttata
    22621 ttaacagatg ccaaatgggc atcaattatg attgagcaaa tattaaacaa tgcattaaaa
    22681 tatgcacgtg gcaaagatgt gtggattacg tttgacgaaa atacaaagaa attatcaatc
    22741 cgagataacg gtatcggcat taatgcgagt gatttaccga aaatctttga taaaggtttc
    22801 tcgggctata acggtagaat aagtgagaaa tcaagcggta ttggtttata tattgtcagc
    22861 acaatctcaa agcgcttagg ccataaagta agtgctacat ctacattaaa cgatggttca
    22921 atattcacca ttcaatttaa ataactccaa tctttcattt ttgtaagatt agcggctgtt
    22981 tttgtaagaa tagataaagg cagccttttc taatcgcgcg taagataaag gtaacaacaa
    23041 actaagaaag gtgccagagg tgaaaaattt gaataatata attgaaataa ataacttaac
    23101 aaagcaatat ggaagtcaga tagcagttaa taatttgagt ataactgttg aaagtggaca
    23161 aatttatggt tttttaggaa gaaatggtgc aggcaaaaca actactataa gaatgctttt
    23221 aggcttaatt aaacctacga aaggtaatat taaaatattt gaaaaagagt tcgaaagtaa
    23281 taaaactgaa attttaaaaa atattggtgc tatggttgaa acgccaggtt tttatagtaa
    23341 tttgacagct aaagagaact taactataaa tgctaaaata ttaggtatac aaaaagaaaa
    23401 tgcaattgaa gaagtgttag aaatagtagg actagcttct gaaaaagtaa aattgtttaa
    23461 aaattattct ttaggtatga agcaacgttt agggattgcg agagctttat tgcacaatcc
    23521 cgaattattg atacttgatg agccgacgaa tggattagat cctattggca taaaagaaat
    23581 tagaaagttg attaaggatc tggctcaatc tagaaatata accattttaa tttcaagtca
    23641 tatattgtca gaaatagagc agttagtaga caaggtgggt attattcata acggagtttt
    23701 gttagaagaa attatgtatg aagatttaaa aaaaaagaac agacaattta taagtatatc
    23761 agtatcagat gaagaaaaag ttgcatgttt gttggaaact aacttcggaa tttatgacta
    23821 taaaattaaa gaaaatggcg aatttaaaat ttattcacat attgatagac aacaagaaat
    23881 taatagatta ttagtattaa acaatattga tgttttccag atgagagtga tagaagataa
    23941 tctagaaact tatttcgaag acttagtagg aggtggcaca attggataat ctactccgta
    24001 cagaatttat taagttaaaa agatcatata tgtttctaat aagtatttta ggtacatgcg
    24061 tagcaccttt tatggtggtt gtagcttctt ttattagtat gcggacgaaa gtaccgactc
    24121 ctaatattgt atttaaacag ttatttgaag aagtcagttt atatcatatg ctaattattg
    24181 gacctcctct atatggggtt ataatagcct atttgtttgg aagagaatat atagaagata
    24241 ctttaaaaaa cttattaatt atacctatat ctagagaaag ttttttagta agtaaaataa
    24301 tattattatt cttgtggatt caaacactat ctgttattgc atggttgcta actttaatgc
    24361 taggtatgct attgcatttt caagggttaa gccagagttt aataattgat tcattcttta
    24421 catttgttat tggcggagtg ttattatgga tattatctcc accaataatt attttgtcga
    24481 tatattttaa aaattatgtt cccacaattg ttttaaccat aataattact ttgataaatt
    24541 taatgactgc taattctgaa catagaggat tatttccttg ggctgcagtt ggagacatat
    24601 ctagaggaac attacctaat acttatccat ttctattatc tttaattatc ataattgtta
    24661 catctatatt cagtgtaatt atattattct catactttaa aaaaactgat ataagttaaa
    24721 aggaggagaa aaatgggttt tatagagcag attaaagcat ttattttagg tgtagttgaa
    24781 gggttgacag aatttgctcc agtatcatca acaggtcata tgattattgt tgatgatatg
    24841 tggttaaaca ctgctgacga tttaggaagt gcgtctgcaa ctacttttaa ggtggtaata
    24901 cagttaggag gttctgttgc aaagttgaat ttat
//
