LOCUS       CP049444               20722 bp    DNA     circular BCT 24-SEP-2020
DEFINITION  Staphylococcus aureus strain pt251 plasmid pER06541.3A.2, complete
            sequence.
ACCESSION   CP049444
VERSION     CP049444.1
DBLINK      BioProject: PRJNA470993
            BioSample: SAMN12331068
KEYWORDS    .
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 20722)
  AUTHORS   Caban,A.B., Pak,T., Kumaresh,A., Dupper,A., Chacko,K.,
            Sullivan,M.J., Altman,D.R. and van Bakel,H.
  TITLE     PathoSPOT genomic surveillance reveals prolonged under the radar
            outbreaks of nosocomial methicillin resistant S. aureus bloodstream
            infections
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 20722)
  AUTHORS   Caban,A.B., Pak,T., Kumaresh,A., Dupper,A., Chacko,K.,
            Sullivan,M.J., Altman,D.R. and van Bakel,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-FEB-2020) Genetics and Genomic Sciences, Icahn School
            of Medicine, One Gustave L. Levy Place Box 1498, New York, NY 10029,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 112.853030216648x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 02/28/2020 16:21:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 2,859
            CDSs (total)                      :: 2,777
            Genes (coding)                    :: 2,690
            CDSs (with protein)               :: 2,690
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 87
            CDSs (without protein)            :: 87
            Pseudo Genes (ambiguous residues) :: 0 of 87
            Pseudo Genes (frameshifted)       :: 55 of 87
            Pseudo Genes (incomplete)         :: 15 of 87
            Pseudo Genes (internal stop)      :: 30 of 87
            Pseudo Genes (multiple problems)  :: 12 of 87
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..20722
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="pt251"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pER06541.3A.2"
                     /geo_loc_name="USA:New York City"
                     /lat_lon="40.7903114 N 73.9528738 W"
                     /collection_date="2016"
                     /collected_by="Mount Sinai Hospital"
     gene            join(20722,1..626)
                     /locus_tag="FPP14_14175"
     CDS             join(20722,1..626)
                     /locus_tag="FPP14_14175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000593102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="QNW86935.1"
                     /translation="MIKLENVFVKKGNKNILDGCNFNFEKGKSYALVGESGAGKSTLLN
                     IIAGFEDVSQGSIYIEDKLLKKKVDFYRYTLGYLFQNFSLLENQTISQNLDLALKFKKN
                     KKDNMNLKKEVLKKVGLDLDIKRIVSSLSGGEQQRVALARLILKDPKIILADEPTGSLD
                     TKNGKIVIDLLLKLLDENKTMIVVTHDLELAKRFDVIVNISELRS"
                     /name="ABC transporter ATP-binding protein"
     gene            864..1169
                     /locus_tag="FPP14_14180"
     CDS             864..1169
                     /locus_tag="FPP14_14180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000122363.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase"
                     /protein_id="QNW86936.1"
                     /translation="MSYSIIRVVKVKSKTNTRGIQRHIQRENKNYENIDIDLSKSYLNY
                     DLVNDTKFDFNKKIDEKIEKNYKGKRKIRTDAIKHIDGLITSDNVFFNQLSEEETK"
                     /name="recombinase"
     gene            1194..1493
                     /locus_tag="FPP14_14185"
     CDS             1194..1493
                     /locus_tag="FPP14_14185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000390798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase"
                     /protein_id="QNW86937.1"
                     /translation="MEEEYGKENLLYATVHMDEITPHMHYGVVLITKDGRLSAKEVVGN
                     KKALTEFQDRFNTYINKQGYDLKRGISRQLTKEKHDQVSRYKQKTEYHKQMHMR"
                     /name="recombinase"
     gene            1587..2132
                     /locus_tag="FPP14_14190"
     CDS             1587..2132
                     /locus_tag="FPP14_14190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001805533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase"
                     /protein_id="QNW86938.1"
                     /translation="MYEIKTKNVGGWFHKEKQETGNIVITKTDFEKYTKQIKAAQMILD
                     DYECIKSGKSLKKAEKQNESLVNELTSVHMENEKLVEEFNDLAQRYNYLLSENEKKDKE
                     LNYTLKLFNQVFKIIKSMMKEERYHTLINHIDNHLDNSKIREVMTIDNNDEQFFKKKYQ
                     AQEREIIFKEDREDGYTL"
                     /name="recombinase"
     gene            2516..3376
                     /locus_tag="FPP14_14195"
     CDS             2516..3376
                     /locus_tag="FPP14_14195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000145511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="QNW86939.1"
                     /translation="MTGETVVYKNEMNLVPLRRFTATEINLFFAMCNKLKEQDTNTLRL
                     SFDELKKLSNYSPETRNINRFANDLDNVYKKMLNLTIRYEDDDVIERFVLFNHYRIHKR
                     EQYLEISTSSNLKHILNSITNNFTKFELKEMTRLKSTYSKNMFRLLKQYKHTGYLKIHI
                     DDFKNRLDIPKSYRMTDINKNVFKPIIIELGSIFNNLTINKIKAKKGRKIEWIEFTFDA
                     EKRIHNKRQPQMSKIDKSRQYVRREKTPKWLEERSYEKQPQKDYDPQLEKEREDFLKQL
                     ELNWE"
                     /name="replication initiation protein"
     gene            3463..3804
                     /locus_tag="FPP14_14200"
     CDS             3463..3804
                     /locus_tag="FPP14_14200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000761340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="QNW86940.1"
                     /translation="MKLAEDIKEQRELKGWSQEELANILKVSRQSVSKWESAKNYPSLD
                     ILIAMSDLFGISLEHLIKGDARFKKVILEGNYRESNRVPSIVDFLYDFWWLFFPVAGFL
                     VWAIHSFMG"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(4043..4114)
                     /locus_tag="FPP14_14205"
     CDS             complement(4043..4114)
                     /locus_tag="FPP14_14205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="QNW86955.1"
                     /translation="MNEILVHIMTTAISGCLVTLFGY"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            4263..4448
                     /locus_tag="FPP14_14210"
     CDS             4263..4448
                     /locus_tag="FPP14_14210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000466619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QNW86941.1"
                     /translation="MFGDQRQEATKYVIKEGYQDIYFLNKNGEWYYFEVRSVWRGKHII
                     RVKDGLLGWRKEIVTE"
                     /name="hypothetical protein"
     gene            complement(4667..5410)
                     /locus_tag="FPP14_14215"
     CDS             complement(4667..5410)
                     /locus_tag="FPP14_14215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002508633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="QNW86942.1"
                     /translation="MKSVKRLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESATEDKQKKESDNINFESKSDAQIVEILKNQINTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNAR
                     QNVDAQEKTYTTSPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAQREDVSANPND
                     NDSDIEEKSEETEPKKGFWSRLFGN"
                     /name="DUF536 domain-containing protein"
     gene            5820..6496
                     /locus_tag="FPP14_14220"
                     /pseudo=""
     CDS             5820..6496
                     /locus_tag="FPP14_14220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            6480..6789
                     /locus_tag="FPP14_14225"
                     /pseudo=""
     CDS             6480..6789
                     /locus_tag="FPP14_14225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002483623.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            8000..8617
                     /gene="cadD"
                     /locus_tag="FPP14_14230"
     ARG             8001..8614
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="99.51"
                     /coverage="100.0"
     gene            8636..8983
                     /locus_tag="FPP14_14235"
     CDS             8636..8983
                     /locus_tag="FPP14_14235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="QNW86944.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNQEGF"
                     /name="helix-turn-helix transcriptional regulator"
     gene            9143..9235
                     /locus_tag="FPP14_14240"
     CDS             9143..9235
                     /locus_tag="FPP14_14240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="QNW86945.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            9447..10424
                     /locus_tag="FPP14_14245"
     CDS             9447..10424
                     /locus_tag="FPP14_14245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4062 domain-containing protein"
                     /protein_id="QNW86946.1"
                     /translation="MSNTKIKYQIFISSTYLDLIEERQAVVEAVLNSNNIPAGMELFNS
                     SSKSQWEIITQWINESDAVILLLGSSYGTIDSEENISYTEMEYNFAKSLGKPIYVFEMN
                     KASTESAEKSKKLDEFKTKVKENRLISPNINDISELKSKVSQTLMQSVPSEIKENSGWI
                     RVQDCGKNVKKLDAIQRDLDTYDFLKEELYKIFMYVKTFYFQHTPFDDSYIEDIENYLL
                     NYENNPHKSFMKIKVYDYKNFLKHLKNILILIKQGKKPLAQAGHFKLSFYEEDLKLLQK
                     NYKTTLVDIKGLNKHFYKECDRCLKAYNIFIIYFILSINKHLYE"
                     /name="DUF4062 domain-containing protein"
     gene            complement(10543..11358)
                     /locus_tag="FPP14_14250"
     CDS             complement(10543..11358)
                     /locus_tag="FPP14_14250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019467708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="QNW86947.1"
                     /translation="MTKNQNFIETKEYKRFAEFCDACIKYQYIGICYGQPGVGKTLSSR
                     YYTNWDTIEKQVNHRGWEDLASKTTDDILSVDKIFYNAPAEKQTKLRNDLYSITAIIDL
                     GQKLHVVNKYGHEHSKHYSDMFKYIDLIIVDEIDRLKVQHLEQLRAIYDEHNLAMIFIG
                     MPGIEKKLSRYPQLYSRIGFAHEFDNLSKDETHHILEYKWQDLGFDLKLEDFTDYEAIT
                     TIIKITKGNFRLIHRLFAQIDRIMDINGLDKISTEVVETARDSLVIGIR"
                     /name="AAA family ATPase"
     gene            complement(11351..12794)
                     /locus_tag="FPP14_14255"
                     /pseudo=""
     CDS             complement(11351..12794)
                     /locus_tag="FPP14_14255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000790716.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DDE-type integrase/transposase/recombinase"
                     /name="DDE-type integrase/transposase/recombinase"
     gene            complement(12766..13359)
                     /locus_tag="FPP14_14260"
     CDS             complement(12766..13359)
                     /locus_tag="FPP14_14260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="QNW86948.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNQKDLNLLKTLYDNGTPI
                     KTIAEQWHVSRTTIYRYLNKLEDKEDEKQGEVSN"
                     /name="recombinase family protein"
     gene            complement(13623..14003)
                     /gene="blaI"
                     /locus_tag="FPP14_14265"
     ARG             complement(13627..14003)
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.21"
                     /coverage="100.0"
     gene            complement(13993..15750)
                     /gene="blaR1"
                     /locus_tag="FPP14_14270"
     ARG             complement(13997..15750)
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="95.56"
                     /coverage="100.0"
     gene            15857..16702
                     /gene="blaZ"
                     /locus_tag="FPP14_14275"
     ARG             15858..16699
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            17071..17679
                     /locus_tag="FPP14_14280"
     CDS             17071..17679
                     /locus_tag="FPP14_14280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001566953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="QNW86956.1"
                     /translation="MIVGYARVSSNDQNLERQLENLKTFCAEKIFTEKQSGKSIENRPV
                     LQEALNFLRMGDRFVVESIDCLGRNYDEVIHTVNYLKDKEVQLMITSLPMMNEVVGNPL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRI
                     IYHRVVEMLEEGQSISKIAKEVNITRQTIYRIKNDNDLI"
                     /name="recombinase family protein"
     gene            18093..18386
                     /locus_tag="FPP14_14285"
     CDS             18093..18386
                     /locus_tag="FPP14_14285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000726503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="QNW86952.1"
                     /translation="MKKKFVSSCIASTILFGTLLGVTYKAEAATVHVAGGVWSHGIGKH
                     YVWSYYSHNKRNHGSTAVGKYSSFSGVARPGVQSKASAPKAWGGNKTFYSLH"
                     /name="lactococcin 972 family bacteriocin"
     gene            18461..20395
                     /locus_tag="FPP14_14290"
     CDS             18461..20395
                     /locus_tag="FPP14_14290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001670421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="QNW86953.1"
                     /translation="MKKFKLFLDFSTLLLISGLLFLFFFKENEEIIPESSNILTISNWD
                     KSNSKSKVLDVIESGAKNQNIQIIKSVKDFDNKKEFFVFNSKRNNSDFIRNKTSLLTPS
                     DLLNREIKGKYYIIGEHFNVEELTSELKKAGLTSEVEYINRNILFFELVIDNDLLVPFI
                     FLGVLYLLYFLYDRGYNLKFYAIQKLHGFSTTRIIFHNIHIKIIYWLVLTAIFFIANIL
                     IIHIANLELDFLMFIRRFIVLLFVFACITTLLWLISYSLLLKLSIPLILKGKKGYKFSI
                     FMGTFTKCIMVLILSFLLAQNLNAYTKLKNIYDSEKIWQKLDNYYTLEISPNIRNSEEK
                     QILETNIYNLIKKSEQLGGLLLKNNNIANPDKNNYIPENGNVFFINNNFLNFYKNINHD
                     FKMIDNHSDKINVFIPPRLQYQKSEIQKNHQGWIDFQKQQNKKVDVQVLSKNVSVFSFD
                     RTTNLKFGYLDSPIVMLLTLDDLTGDFYLAAVSQGGYLFKDLDTLKQLLKDNHLEEEIS
                     GITNYKDSVLNELNETKTKMIITIVTIIINVFILLIATVFETIQYFSWNKKQLLLRKIH
                     GYSLFSSNVRYLTISILLSIMLAYTTHILFGSKILLFIIMSIAIIQHLLQIAYIKYLEK
                     YFKDLMREI"
                     /name="bacteriocin-associated integral membrane family
                     protein"
     gene            20399..20710
                     /locus_tag="FPP14_14295"
     CDS             20399..20710
                     /locus_tag="FPP14_14295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YxeA family protein"
                     /protein_id="QNW86954.1"
                     /translation="MKRTLIIVTIVLLIIILSLLLVRNEHLDRFNPLLKEKVSYAKVPK
                     DTQDYRNITVYSKNGEKKSYKLDFLGYDPTKEYVKVNHKGKYVRSIEYITKDIPSFLK"
                     /name="YxeA family protein"
     ARG             15858..16702
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.8"
                     /coverage="100.0"
     BGC             13093..20722
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          6847..6994
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="81.333"
                     /coverage="100.0"
                     /evalue="2.96e-25"
     Typing          2517..3376
                     /name="rep_cluster_2214"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(4668..5410)
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.866"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          865..1139
                     /name="MOBV"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="94.565"
                     /coverage="100.0"
                     /evalue="4.71e-46"
ORIGIN
        1 tgataaaact tgaaaatgtt tttgtaaaaa aaggtaataa aaacatttta gacggatgta
       61 actttaattt tgaaaaagga aaatcatatg ctttagttgg agaaagtggc gctggaaaat
      121 ctactttact taacataatc gctgggttcg aagatgtatc acaaggaagc atatatattg
      181 aagataagtt actaaaaaag aaagtcgatt tttatagata tacgttaggg tatttgtttc
      241 aaaatttttc tttacttgaa aatcaaacaa tcagtcaaaa tttagattta gccctaaagt
      301 tcaaaaagaa taaaaaagat aatatgaact taaagaaaga agtattaaaa aaggtcggcc
      361 tagatttaga tatcaagaga attgttagtt ctctaagcgg tggtgaacaa caaagagtag
      421 cattggcaag attaatatta aaagatccga aaatcatttt agctgatgaa cctactgggt
      481 cactagatac gaaaaatgga aaaatagtta ttgatttatt attgaagcta cttgatgaaa
      541 ataaaactat gattgtcgta acgcatgatt tagagcttgc gaaacgattt gatgtcatag
      601 tcaatatttc tgagcttaga agttaagaaa tattgatagg tatagccata catagagaaa
      661 aaacaatatg aaatatgatt agtcattact tttgagtttt ttaatttaag gactggattt
      721 tccagtcctt ttttatgatg acaaaaaaca agcctcgcag agcacacgtt tttaatgact
      781 tatttggttt ttaataagtc tagtatgtta aaacttttct gtgtttaggt gttataatca
      841 tatgcagtgg aagttgattt attatgtctt attcaattat tcgagttgtt aaagtgaaat
      901 caaaaacaaa tacaagaggt attcaaagac atattcaaag agaaaataaa aattatgaaa
      961 atatagatat tgatttaagt aagtcatatt taaactatga tttagtcaat gatactaagt
     1021 ttgattttaa taaaaaaatt gatgagaaaa tcgaaaaaaa ttataaaggg aaacgcaaaa
     1081 ttagaacaga tgccattaaa catattgatg gattaattac atcagataat gtgtttttta
     1141 atcaattatc tgaagaagag acaaaatagt tttttaagca tgctaaagcg ttcttggaag
     1201 aagaatacgg taaagaaaat cttttatatg cgacagtaca tatggatgag ataacaccac
     1261 atatgcatta tggcgtagtt cttattacta aagatggacg tttaagtgcg aaagaagttg
     1321 taggtaataa aaaagcatta accgaattcc aagatagatt caatacgtat attaataagc
     1381 aaggctatga tttaaaacga ggaatttcta gacaacttac aaaagaaaaa catgatcaag
     1441 ttagccgtta taaacaaaaa acagaatatc ataaacaaat gcatatgcgc tagaagcaaa
     1501 tagaggatta tttaaagcaa gaaaatgata aattgataca aaactaccaa aaatcattag
     1561 atacgcttaa aaagcttctg agtgtcatgt atgaaattaa aactaaaaat gtaggtggat
     1621 ggtttcataa agagaagcaa gaaacaggca atattgtaat tactaaaact gattttgaaa
     1681 aatacactaa acaaattaaa gcagcacaga tgatattaga tgattatgaa tgtattaaaa
     1741 gtgggaagtc attaaaaaaa gcagagaaac aaaatgaaag tttagttaat gaattgacta
     1801 gtgtccatat ggaaaatgaa aagctggttg aagaatttaa tgatttagca caacgttata
     1861 attatttgtt gtcagagaat gaaaagaaag ataaagaact aaattatacg cttaagttat
     1921 tcaatcaagt ttttaaaatc attaaaagta tgatgaaaga agagcgttat catacactaa
     1981 taaatcatat tgataatcat ttagacaatt ctaaaatacg tgaagtaatg acgatagata
     2041 acaatgatga acagttcttt aagaagaaat atcaagcaca agaacgagaa atcattttta
     2101 aagaagatag agaagatggt tatacattat aaaaatagat atttaaatgc atttgtttga
     2161 ggttaattat tttttaggat gaaaaatagg tagcccccct cgaacttttt aatatatttt
     2221 tataaatctt tttaaaaacc tttttagggg cttgttcagc cctagagcaa caagggattt
     2281 caatgcctaa aggagtgttt ttgccacata aaaggagtgt ttttgccaca taaaaggagt
     2341 gtttttgcca cataaaagga gtgtttttgc cacataaaag gagtgtttta aaaagttgta
     2401 ctccttttat ggtttgacat tgataataaa gtagtttatt gtgaataaaa gttttcaaat
     2461 gggagtgtat attcaaacga tactccttta ggttcgtaat aaagggggct gtatcatgac
     2521 aggagagaca gttgtatata aaaatgaaat gaatttagtt ccattaaggc gatttacagc
     2581 tactgaaatt aatttatttt ttgcgatgtg taataaatta aaagagcaag atactaatac
     2641 attacgtttg tcttttgatg aattaaaaaa attaagtaat tatagtccag aaacacgtaa
     2701 tattaataga tttgctaatg atttagataa tgtgtataaa aagatgttga atttaaccat
     2761 tagatatgaa gatgatgatg taatagaaag attcgtttta ttcaatcatt atagaatcca
     2821 taagcgagaa caatatctag aaatatcaac ttcttcaaat ttaaaacaca tattgaattc
     2881 aattactaat aattttacaa aatttgaatt aaaagaaatg actaggctta aatctacata
     2941 ttctaaaaat atgtttagat tacttaaaca atacaaacat acaggctatt taaaaattca
     3001 catcgatgat tttaaaaatc gtttagatat acctaaatct tatcgtatga ctgatattaa
     3061 caaaaatgtt tttaaaccta ttattattga attaggttct atatttaata atcttactat
     3121 caataaaatc aaagcgaaaa aagggcgtaa aattgaatgg atagagttca catttgacgc
     3181 tgagaaacgc attcataaca aacgacaacc tcaaatgtcc aagatagata aatcaagaca
     3241 atatgtgagg cgtgaaaaga cgcctaaatg gttagaagaa cggtcatatg aaaagcaacc
     3301 tcaaaaagat tacgacccac aattagagaa agaacgagag gattttttaa aacaacttga
     3361 actgaattgg gaataacgca acttttcgtt gcgagttggt taactaaaag tatcgtgact
     3421 tttcaattat tttaattata gtttgagtta aggagtgatt ttatgaaatt agctgaagat
     3481 ataaaagaac agagagaatt aaaaggatgg tctcaagagg aattagccaa tatattaaag
     3541 gtttccagac aaagtgtttc taaatgggaa agtgccaaaa actatccttc cttagatatt
     3601 ttgattgcta tgagcgattt attcggaatc tctttagagc atttaattaa aggagatgca
     3661 cgttttaaaa aagttatttt agagggaaat tatagagaga gtaacagggt accttccata
     3721 gttgattttc tttatgattt ttggtggctt ttctttcctg ttgccggatt tttagtttgg
     3781 gccattcatt cgttcatggg ttgattttaa aatcaaaatt taatgcacat caggcaatat
     3841 gaaaaaggaa agtattttta cgacaccttg aaatgtattg ataagaatag aagagtttac
     3901 aaaaggcaat atgaaatata tactaaaagt aacaagaatt tcgtttgtaa acgcacaaaa
     3961 ccccgaacta ttcgccgtag ttcggggttt tttggtgaat tggctttaat cgtctatatt
     4021 attttttatc acgtttatgg agctaataac caaataacgt aacgagacaa ccactgattg
     4081 ccgttgtcat gatgtgaaca agaatttcat tcataaatcg cacctcctct ctacgccgaa
     4141 ttgacatctg agagatagac gaccttcaca ttataacaaa tctctccttc catgaaataa
     4201 catgaatatt aataaatgtt gttatatatt aaagataaat aaatataagg gtgggattga
     4261 taatgtttgg cgatcaaaga caagaagcta caaaatatgt cattaaagaa ggttatcaag
     4321 atatttattt cctcaacaaa aacggggaat ggtattattt cgaagtaaga agtgtctggc
     4381 gtggcaaaca tattattaga gttaaagatg gtttgttagg ttggagaaaa gaaatagtaa
     4441 ctgaataaag atacaaaata cttgccaatg caaaagaatg aaaacgcgtc aaatcaacga
     4501 tgtataaaag atgcataaaa gataatgaaa gtaaaaagcc ataaatgcct atatgacggc
     4561 atttatggct ttttgtttgg ttaacataat cgatgattat cagaagttca attcacataa
     4621 aaaagcacgg ctaatttatg aacttgtcgt acctttttaa ttaaaattag ttaccaaata
     4681 gacgactcca aaaccccttt ttaggttccg tttcttcact cttttcttct atatcactat
     4741 cattgtcatt tggattagct gaaacgtctt ctctttgtgc ttcttcacct tgtgtacttt
     4801 cgtcgctttg acttccagat atatccttat attgaatctc tgtttcttta gtttcttcct
     4861 gatctcggtt aatatttaca ggactagtag tatatgtttt ttcttgtgca tcaacgtttt
     4921 gtctagcgtt agtagatgta tcaaagggat aattaaggtg tttttctttt tctaattgat
     4981 tttctaattt ttgaatcttt ttattactct ctaatgccag aacttgctga ttctcaagca
     5041 attttgatct ttcttgcaac tcttttctgt aaaattcaat tgttgtttca tgacgacttt
     5101 cttgtttttc aatttgatta tttaaagtat taatctgatt tttaagtatt tctactattt
     5161 gagcatcgct tttagattca aaattaatat tatccgactc ttttttttgt ttgtcttcag
     5221 tagcactttc aaaaccatat ttctttttat tttcatttac tctttgaatg attttttcta
     5281 tatcggtatc ttctttaata aacgaagtgt tttcctgttt tattgtctct atattcaatc
     5341 tcttaatatt attaaaaatc gtttgcttac taacccctaa ttcttcactc aaccttttta
     5401 cacttttcat atcatcaacc ctttataaaa tgtttataaa cccttagtaa aatattataa
     5461 gcttataacg attaataata aagtaatcga caaataaaaa tataaattcg ccaacctttt
     5521 tatcaagggt ttgtaaaggg tttatggtgt ttatcaaagg tttataaacc tatattttcc
     5581 cttttttaag tttattcaaa gtgctataat aaccttaata taacaaaaac cccaactact
     5641 ggtaatagtc ggggtttggt aataaaacgt ttagaaactg tttatttata taattttcga
     5701 tacttagatt atataatgaa taatatctta gtgcaagcac ctagattatt aaataaacac
     5761 aaaaatgtaa gcgttttatt acctcttacc aaactaaaat tcggaaagag gtttttatta
     5821 tgtcaattaa actttacaac ataaatgagg aatacagaga aaagttttat caaataccga
     5881 aagtattttt tacaaatcct aaatatatca agttatccaa tgatgcaaaa atggcatggg
     5941 gtattcttag agatcgttta gatttatcaa ttaaaaatgg ttgggttgat tctaaaacag
     6001 gtaatattta tttttattac aaaaatgaaa acccacaaaa tatattaaat tgtaaaaaag
     6061 ataaagtaat taaaataaag aaagaactta attgaagccg aattactact acaagaaaga
     6121 caaggtttaa ataagacaaa taaactttat ttagttaaac cagaagtaac agaagatgat
     6181 atttataaaa ttcaaaagca agaaaacact gttgagagca gcaatggcaa ggaagtcgga
     6241 aaaaccgact tcaagaagtc gataaaacag aatctaatga tactgaactt agctatactg
     6301 aatctaacaa tactgaaata aatgatatga atgacttgaa tgatatagag tccgaaaatg
     6361 aaattagtaa tcattcaagt caatgcaagg ttatttaatg caaacaattt taactgaatt
     6421 tgaagaaaca catgcacttt atatgcgccg taaaaacatg aaacaatata atatctttaa
     6481 tcaatcattc aaatgatttt ataacaatca aagatacatc aaaatatttc gttaaatcat
     6541 ctgacttttt aactgatagc gatgaaaaaa tcaagaaatt gtcagtgatc tagaaaaaga
     6601 tttgtatcga aaacgtatgt taagttatgg tggattgctt aaataaaaac ataaaatttt
     6661 aaacttagac gatgctgaag atggcaattt aattaataca agtgatgaag ataaaatagc
     6721 aaatgaagaa gaaaaggcac attcgattac ggcaattttg aaaagcaaaa ttattattta
     6781 aggcattagt gataactgat gtcttttttt attacttttt tgtaaaaaaa gtgctgtctt
     6841 atttttgtga caaatgctgt atgtagtgtc acaaaagtgt gacacttgag ctttttatga
     6901 ccccacacaa aaacattttc gaagccttga aatatctggc tttgccagat cccccattca
     6961 ttgatgggga caaatttccc ttatgctctt acggagattt tagagttaaa ttaaaatttc
     7021 taagtttttg ataagaaaag ccctgcagga atttagaaga acgtggggaa gttttaaaga
     7081 attttatgct aatttttaat ttgcatgtaa atgggcagtg tctaaaaaat agttattgtt
     7141 tttgctcaaa tttttgtttt tgaaaatagc atatatttat ttggctcata tttgcgtttt
     7201 aaaagcgtat ataagtttta gatataaaac tatatgaatc acccctaaat ctttaaaatg
     7261 ccctcttaaa attcaaaata agggcataaa aaataaaagc ccccccagat aaagtgaggt
     7321 agctttttct ttcgacgccg tatcgtcgat gtaattcaaa aaagttatgg gctataaatc
     7381 tacatcactt tttcaagaat gtagtagcaa tattcaacgc aaattaattt ttataactgc
     7441 tcggaatatc tcaagccgtt tctttaattt tgaaataaaa aaatcgacga aggtcgatta
     7501 cgtttttgca catgtcgatt tatccgacgt ataagtgcgc ccttacggga tttaactaga
     7561 ttataacgac gaattttaga cctgtaaagc aataacaatt aggtctacca ggtagataaa
     7621 gtgtacaaag tagaaccgaa aaagttattt attttgaaga tttttcgtag atataatttg
     7681 ctaataaact tcctaaaact gaataaagaa aaatagttaa actcatgtaa tcactccata
     7741 attctgaagt gtctccatgt ctacgcatag acacacattt atgccgagaa aatttattgt
     7801 gcgttgagaa gaacccttaa ctaaacttgc agacgaatgt cggcatagcg tgagctatta
     7861 agccgaccat tcgacaagtt ttgggattgt taagggttcc gaggctcaac gtcaataaag
     7921 caattggaat aaagcaccta tgattattta aaaatataag ttataataca ttcaaaaata
     7981 tttttgaatg aggtgtatta tgattcaaac ggttgttgct gctgctgttc tttatattgc
     8041 tacagcagtt gatttattag taattttatt aatatttttt gctagagcaa agactagaaa
     8101 agaatataga aatatttatg ttggtcaata tttagggtct attattttaa tattagttag
     8161 tttgttttta gcttttgtat taaattatgt tccagaaaag tggatattag gtttattggg
     8221 tttaatacca atttatcttg gaattaaagt ggctatttat gatgattgtg aaggagaaaa
     8281 gagagctaaa aaagaattga atgaaaaagg attgtctaaa ttagttggta cggttgcaat
     8341 tgttacgata gcaagttgtg gcgccgataa tattggttta tttgttccgt attttgtgac
     8401 attaagtgtt actaatttat tacttactct gtttgtcttt ttaattttaa ttttcttctt
     8461 ggtgtttact gcacaaaaat tagctaatat cccaggaatt ggagaaattg ttgagaaatt
     8521 tagtcgttgg attatggcta tcatttatat agctttaggt ttatttatta ttattgaaaa
     8581 tgacactatt caaacaattt taggatttat attttaattt agggtgtgat tttatatgag
     8641 ttatgaaaat acttgtgatg tgatctgtgt acatgaggat aaagttaaca atgctttaag
     8701 ttttttagaa gatgataaat ctaagaaatt acttaacatt ttagaaaaaa tttgtgatga
     8761 gaagaaattg aaaatcatat tatctttgat taaagaagat gagttgtgtg tttgtgatat
     8821 ttctttgata ttgaaaatga gtgttgcttc aacttcacat catttaaggc ttttatataa
     8881 aaatgaggta cttgattttt ataaagatgg aaagatggca tattatttta ttaaagacga
     8941 tgaaataaga gagtttttct ctaaaaatca ggagggtttt tgaaacgagt ttcttcttgt
     9001 cttgatacta taaaaaacaa agttatataa cataagacga cttatcggaa gttatctatc
     9061 atcgtatatt cggagatgat ataatataca ggtcgcctat ctctcaggcg tcaattcaga
     9121 cgcagagagg aggtgcatta ctttgctaat cattttcgtt cacatcatag caccagtcat
     9181 cagtggctgt gctgttgcgt attatactta ttggcttagt aaacgcaaca aataattaat
     9241 aggcgacttt ataagccagc atcgaaaaaa tccccacact attgcagtag tgtggggatt
     9301 ggtgcattaa ttgttaatca ttttcgttat ctagattata acactggtta gtagaggaat
     9361 gcaaaaagat aatattttaa gtagtctttt tggatattat catatgatat atttatgtaa
     9421 attgattttt tattaaagga gcatatatga gtaatactaa aattaaatat caaattttta
     9481 tttcatcaac ttatttagat ttaatagaag agcgtcaagc agtagtagaa gcagttttaa
     9541 acagtaataa tattccagca ggtatggaac tttttaactc aagtagtaaa agccaatggg
     9601 aaataataac acaatggatc aatgaatcag atgcagtgat attattgtta ggttctagtt
     9661 atggaacaat tgatagtgaa gaaaatatta gctatacaga aatggagtac aattttgcta
     9721 aatctttagg taaacctata tatgtttttg agatgaataa agcatctacc gaatccgcgg
     9781 aaaagtctaa aaaattagat gagtttaaga caaaagttaa agaaaataga ctaattagtc
     9841 caaatattaa tgatatttcg gaattaaaaa gtaaagtatc tcagacttta atgcaaagtg
     9901 tacctagtga aattaaagaa aatagtggat ggataagagt acaggattgt ggtaaaaatg
     9961 taaaaaaatt ggatgctata caaagagatt tagatacata tgattttttg aaagaagaac
    10021 tttataaaat attcatgtat gtaaaaactt tttatttcca gcacacacca tttgatgata
    10081 gttatattga agatatagaa aactacctgc taaattatga aaataatcca cataaatcat
    10141 tcatgaaaat aaaagtttat gattataaaa actttttaaa acatttaaaa aacatattga
    10201 ttttaattaa acaaggaaaa aagccattag ctcaagccgg tcattttaaa ttaagctttt
    10261 acgaagagga tttaaaattg ttacaaaaaa attataagac tacgctagtc gatattaaag
    10321 gattgaataa acatttttat aaggaatgtg ataggtgctt aaaagcatat aatattttta
    10381 ttatatattt tatattgagt ataaataaac atttatatga atgatataag tacacctaat
    10441 catacatata taattgttgt cactttactc gatatatgag aatgacttta cctaataaat
    10501 gagaaaagca acgcactata ttaaaatgcg ttgctttttc tattatcgaa tacctataac
    10561 taaactatct ctagctgttt ctacaacttc tgtacttatt ttatctaaac catttatatc
    10621 cataattctg tctatctgcg caaataaacg atgaatcagc ctaaaattcc cttttgtaat
    10681 tttaataatc gtcgttattg cctcataatc agtaaagtct tcgagtttta aatcaaatcc
    10741 taagtcttgc cacttatatt ctaatatatg atgcgtctca tctttactta gattatcaaa
    10801 ttcatgcgca aaacctatac gcgaatataa ttgaggataa cgagatagtt ttttctctat
    10861 acccggcata ccaataaata tcattgctaa attatgttca tcataaatag ctcttaattg
    10921 ctctaaatgt tgcactttaa ggcgatcaat ctcatctact ataattaaat caatatattt
    10981 aaacatatca ctataatgtt tactatgttc atgtccatac ttatttacaa catgtaattt
    11041 ttgacccaaa tcaatgattg cagtaatact atataaatca ttccttaatt tagtttgttt
    11101 ttctgctggt gcattataaa atattttatc caccgatagt atgtcatcgg tcgttttact
    11161 agctaaatct tcccaacctc tatggttaac ttgtttttca atagtatccc aatttgtgta
    11221 atacctagac gataaagttt ttccgacacc aggttgacca taacatatac caatatactg
    11281 atatttaata caagcatcac aaaattcagc aaagcgttta tactctttcg tttcaatgaa
    11341 attttgattt ttagtcatta cgatatctct ttaatttttt gacgttttta gtcgtttctt
    11401 gaggtgaata accacaattt ttttcttcct taattaattc cgtggtactt ggactagcaa
    11461 tattttgttt taagtgtttt cttctctgac tacgagcgtg ctgtatgtct tttatatcta
    11521 tggagtaatc agctatttct ggacatatag cagtacaaag aaattcatct ctataaaaca
    11581 cacgtatttc agccatatca tttgggttat aacgaatcag tacatattca cctacataag
    11641 cttctagatt agtattactg tatcgaaaac cttgaaaatg aatgccatct gaatgaactt
    11701 ttctagattt aggtatttcc aacaataata aatcaagttg ttctaagcta cttggcatat
    11761 tagggaaaaa gtgattacta ttccaatgac tgataggcgt ggtatgaata gtactatgtt
    11821 ctttttgatt ataatcttca attaaaaagt aacgtaattt ttcttcaaaa ttgtgaaaat
    11881 ttattagatt actaggagta tcattattgt ttatatatcc aggcagttgt tctaagaaag
    11941 tttgattaac tgtctgaaag aatcgttcta tttttccacg accacgagga acaccaactt
    12001 tcgaaaacat caagttaatt ttcaaatcaa tagcgacttg ttccatatga tgtgaagtaa
    12061 agtcacttcc atgatctgtg tagaattttt cgggtatacc acacactggc caattggtat
    12121 catttttatt ccatattgct tggtgtagtg ttaatgctgt gttttgagca ttggggggca
    12181 tcaaaactta agaaatagcc tgcaattgca cgactatagt catccataat aatagttagc
    12241 catggtctat tgatattacc tttttggtct aatataaaga tatctagcaa agtatggtct
    12301 gcttgccata tttcattggg tctcgaggat tctctaattt gtattaaatc gtacttattt
    12361 tgatagtatt tttcaccctg atgagagaaa tcaataacag acttaggcat cgctttaata
    12421 acactataaa tttgtttata acttggtata tcaaaattat tttctttaca gtaattagtg
    12481 attttcctat gaattgtggc tatactattt cttttattca taagcgcaag gcgttcaatt
    12541 tcatcaatta tctttggttc tattttacgt gttcctttat cagctcttgt cgcatagatt
    12601 agtcctttaa gtccttgttc tttatatgac ttattccacc tataaagggt gcttaacgca
    12661 atccctttac ttttagaaat acttgataaa gattgttcgc ctaggataaa aggttttata
    12721 atattgtact tttgagtagc ttttttacgt ttggcttcag aaaaattagt tagatacttc
    12781 tccttgtttt tcatcttcct tgtcctccaa tttattgagg taacgataaa ttgttgtacg
    12841 tgaaacatgc cactgttctg caattgtctt aattggcgtg ccattatcat aaagggtctt
    12901 aagtaagttt aaatcttttt gatttaattt ttctggtctg cctccatatc ggcctctagc
    12961 acgtgctgca attcggccag ctgaagaacg ctctaaaatt aaattacgtt caaattctgc
    13021 aaatgctgcg aataaatgaa ataataattg tccagttgaa cttgatttat ccattgttat
    13081 attttcttct aaactatgga aacttacacc tcgttcgtta agctcattaa ctaatgtgat
    13141 taaatcctcc atattacgtc ccaatctatc taatctccaa acaacaatcg tatctcctga
    13201 cctcgcaaat tcaattgctt tatctaaacc aggtctttta ctttttgaac cactcatatg
    13261 gtcattaaat atcttttcac aaccatatgt atttaatcga tcctcctgta aatttaaatt
    13321 ttgtaatcca gttgaaactc ttgcataacc tattttcaaa atacaaacct cctatataca
    13381 tcttcagtgt accataactt aattacaagg tcttttatga acatagattt tttgttgggt
    13441 ttttgaacac ataatcctat gtaattctta cttatttaga cataaaagaa gagtgtacag
    13501 aaaatggtta ttttctgtac actctcatct ttaataatat attttaaatg tcattaacaa
    13561 aactaattta ataagagtca agcatagttt acatatgtat tatgtttgaa acatacctct
    13621 aattactttt tactaatatc atttaaaata tctcgcaatt cttcaatttc tttgttattt
    13681 aattcttcat ttttcgcaaa attcaacact aaacttttca tatcccctcc atacagttta
    13741 ttaagaaagg ttttagcagt tttcatttta atatcgtctt ctttaatatt tgatgagtaa
    13801 aaataaatat tttctgattt gtatcgtttt ataatctctt ttttatatag tcttgtgatt
    13861 aatgttctaa tcgttttatc actaacttct ttatattttt gaatttcaac tacaatttca
    13921 ttagctgata ctgatttttt atcccatatt atattcataa catcccattc agccatagat
    13981 atttcaactt gcttattggc catttaaaac acccattcct tttaatattt tttcacttat
    14041 taattcagca tttttcccag acgggtttcc atctgataaa tgtgtagcaa aataatactt
    14101 atcatgattt gtaattacgt aacctacaaa ccacccatta ttatacttcc cgtttactat
    14161 acctgtacct gttttcccat acagttcata cttttcattt ttcttaatca ataatgaaga
    14221 agataattga ttctttgctt ttttactaaa atggttattt tgttccatca tatttttaaa
    14281 aactattact tgttcaagat tagatatttt caaactatct tccatccaat agcttttata
    14341 acttcccaaa ttttcattac cataatttaa ttgcttgagt tgagccgcag tatagttctt
    14401 tggtatttga ttactaatac gttcgaagta ccaattaact gaattttgca ttgctgtatt
    14461 taaatcttgt tccttattcc aagactcgaa aagataatgt ttatgattcc atgacatacg
    14521 tgaattttta tcacttataa tatgacggtc aagtccaaac agtgctaaat aaattttgta
    14581 agttgaatca ggagaatatc tttttctact ttctttttca ttataaatat agtatttgtc
    14641 tttcttcatg ctgtacataa cgaaagatcc actatttgaa ccaaaatttt tactttcatc
    14701 taaaatttgg taatcgcttt gtaagggctt tttataatta taatcagtta aggattgccc
    14761 cattaaaaac tggctttgaa ttatcatgat aaaaaaagta aaaatacaaa taaaaattag
    14821 aattaatttt gactgctttt tcagatcggc ttcttttata ttaattaatc tatttttgag
    14881 taatgatttt ttaccattaa atgaatggct taatatattt ttgttgaaaa atgaggtttt
    14941 taatacggag tccataatag attccgcata agttttaaat tcatttttgt taatattatt
    15001 aaggacaaat ctatcggctt ctacttcatt gtcatgaatt atctttcttt ttacaatatg
    15061 tactaatgga ttgtaactca taataataga gaagatatta aagataatta aatgtaaagt
    15121 atctctattt ttagcatgag catattcatg cagtattata tattttagtc ttttatcaat
    15181 tacactttta aaatatgaac taggaatcaa aataatatat ttcccatacc aaaaagttat
    15241 tggagattga atagcctctg cttttcgaat cacaatattt tttttatatt gatggttgaa
    15301 aagtatcgta tctattttat ttttttcatt ttcgtttaga taaagtgact gtttctttaa
    15361 atatttaaga tataataagg ctttcaaaaa tttaaaactt aaaataataa ctaaaactat
    15421 ccaaataact gtgcagatat tatcaattga atcccaatta aacttatgga tatctgttgc
    15481 gaactcttga acaggtttgg tggtaattat gttatggttc aagtcgtgtg acttactttc
    15541 aactgtgggc gcttgattat tcacattatt aaattttata aaagagaatt taattgggat
    15601 aaaaggaatt aatccagcaa gcacagttag ataccaaact ttataattta aactataatt
    15661 aaaatagcgt tttaatatgt acctaaaaaa tactaacaat agaaatataa aacaaaagct
    15721 tactacactc attattagta atttagccat tttgacacct tctttcaaat atttataata
    15781 aacaattgac atcaatatta caattgtaat attattgttt tgtaaaaatt acaactgtaa
    15841 tatcggaggg tttattttga aaaagttaat atttttaatt gtaatggctt tagttttaag
    15901 tgcatgtaat tcaaacagtt cacatgccaa agagttaaat gatttagaaa aaaaatataa
    15961 tgctcatatt ggtgtttatg ctttagatac taaaagtggt aaggaagtaa aatttaattc
    16021 agataagaga tttgcctatg cttcgacttc aaaagcgata aatagtgcta ttttgttaga
    16081 acaagtacct tataataagt taaataaaaa agtacatatt aacaaagatg atatagttgc
    16141 ttattctcct attttagaaa aatatgtagg aaaagacatc actttaaaag aacttattga
    16201 ggcttcaatg acatatagtg ataatacagc aaacaataaa attataaaag aaatcggtgg
    16261 aatcaaaaaa gttaaacaac gtctaaaaga actaggagat aaagtaacaa atccagttag
    16321 atatgagata gaattaaatt actattcgcc aaagagcaaa aaagatactt caacgcctgc
    16381 tgctttcggc aagactttaa ataaacttat cgcaaatgga aaattaagca aaaaaaataa
    16441 aaatttctta cttgatttaa tgtttaataa taaaaacgga gacactttaa ttaaagatgg
    16501 tgttccaaaa gactataagg ttgctgataa aagtggtcaa gcaataacat atgcttctag
    16561 aaatgatgtt gcttttgttt atcctaaggg ccaatctgaa cctattgttt tagtcatttt
    16621 tacgaataaa gacaataaaa gtgataagcc aaatgataag ttgataagtg aaaccgccaa
    16681 gagtgtaatg aaggaatttt aatattctaa atgcataata aatactgata acatcttata
    16741 gtttgtatta tattttctat tatcgttgac atgtataatt ttgatatcaa aacctgattt
    16801 tccctttatt attttcgaga tttattttct taattctctt taacaaacta gaaatattgt
    16861 atatacaaaa aatcataaat aatagatgaa tagtttaatt ataggtgttc atcaatcgaa
    16921 aaagcaacgt atcttattta aagtgcgttg cttttttctc atttataagg ttaaataatt
    16981 ctcatatatc aagcaaagtg acataattgt tgaatttata gtaactgaaa cgtatgatta
    17041 gggtgtatat taattatgag atggaaatca atgattgttg gctatgcgag agtatcatcg
    17101 aacgatcaaa atttagaaag acaacttgaa aatttaaaga cgttttgtgc tgaaaaaata
    17161 tttacagaaa aacagtctgg gaaatctatt gaaaatagac cagtacttca agaagcactt
    17221 aactttttga ggatgggaga tcggtttgta gtagaatcca ttgattgttt aggtcgtaat
    17281 tatgatgaag tgattcatac cgttaattat ttaaaagaca aagaagtaca attaatgatt
    17341 actagcttac ctatgatgaa tgaagtggtt ggcaatccat tactggataa gtttatgaaa
    17401 gatttaatta ttcaaatatt agcaatggtt tcagaacaag agagaaatga aagtaaacgt
    17461 cgacaagcgc aaggaattca agttgcgaag gaaaaaggcg tatataaagg gcgcccctta
    17521 ctttattcac caaatgctaa agatccacag aaacgtatta tttatcatcg cgttgtagaa
    17581 atgttagaag aaggccaatc aattagtaaa attgcgaaag aagtaaatat aacaaggcag
    17641 acgatttaca gaattaaaaa cgataatgat ttgatttaat aaactttgtt tcaatgcaac
    17701 tgagagcttc tcacagcgtc tcaaaacaga tgattataat ctattatgag tttttaataa
    17761 taagacaaga aaagagagcg taaatatgct ctctcttttt ctcattaacg aatgtttata
    17821 acgcaatcat gatgagagta ttaatacagt taattatttg aaatacttta gtttatataa
    17881 tgttgaatta taggtagtga aattgtattt attatacatt gtcatatcgt tgtttaatga
    17941 tagttaattt aaggataata gaattaatat tatatataga tgaacaaaac aagcaacaga
    18001 gcagaaaaaa cacttttaga ttatttttac tcattctcta ttttatttat ttttgctata
    18061 ataaataaag aatattaaat ggaggtgttt ttatgaaaaa gaaatttgtt tctagttgta
    18121 ttgctagtac aatcttattc ggcactttat taggtgtaac ttataaagct gaagctgcaa
    18181 cagtacatgt agctggtggt gtttggagcc atggtattgg aaaacattac gtatggtctt
    18241 attatagtca caataaaaga aatcatggtt caacagcagt agggaaatat tcatctttta
    18301 gtggtgttgc tcgacctggt gttcaatcta aggcatctgc tccaaaggct tggggtggaa
    18361 acaaaacatt ttatagtctt cactaattac atatattaat taaggagaat agacagaatt
    18421 aagtaaactt aattctgtct attctcttga aagaggcaat atgaaaaaat tcaaattatt
    18481 tttagatttt agtactttat tattaatttc agggctatta tttttatttt tcttcaaaga
    18541 aaatgaagaa attatacctg aaagttccaa tattttaaca atctctaatt gggataaatc
    18601 taacagtaaa tcaaaagtgt tagatgtcat tgaatcaggc gccaaaaatc aaaatataca
    18661 aataattaaa tccgttaaag attttgataa taaaaaagaa ttttttgttt tcaactcaaa
    18721 acgaaataat tctgacttta tacgtaataa aacatcactt ttaactccat cagatttatt
    18781 aaacagagag ataaaaggaa agtattatat tattggtgaa catttcaatg tagaagagct
    18841 tacgagtgaa ttaaaaaaag ctggtttaac atctgaagtt gaatacataa atagaaacat
    18901 attatttttt gaattagtca tagataatga tttattagtg cctttcatat tcttaggcgt
    18961 attatatctt ttgtacttct tatatgacag aggatataat ttgaaatttt atgctattca
    19021 aaagctacat ggcttttcaa ctacacgcat tatttttcat aatattcata taaaaatcat
    19081 ttattggcta gtacttaccg ctattttctt tattgctaat atattaatca ttcatatagc
    19141 caatttagaa ttggatttct taatgtttat tcgtagattt atcgtgttgc tttttgtttt
    19201 tgcttgtatt actacattgc tgtggctgat ttcgtatagt cttcttttga agttaagtat
    19261 tccattaatc ttaaaaggga aaaaaggata taagttttca atatttatgg gtaccttcac
    19321 caaatgtatc atggtgctaa tactatcttt tttactggca caaaatttaa atgcttatac
    19381 gaagttaaag aatatatatg actctgaaaa aatctggcaa aagttagata attactatac
    19441 attagagatt tctcctaata ttagaaattc agaagaaaaa caaattttag aaactaatat
    19501 atacaattta attaagaaaa gcgaacaact tggtggattg cttttaaaga ataataatat
    19561 agccaatccc gataaaaaca attacattcc tgaaaatggc aatgtctttt ttatcaataa
    19621 caattttctg aatttctata aaaatataaa tcatgatttt aaaatgattg acaatcattc
    19681 ggataaaata aacgtgttta ttcctccaag gttacaatat caaaaatctg aaattcaaaa
    19741 aaatcaccaa ggatggattg actttcaaaa gcaacaaaac aaaaaagtag atgtgcaagt
    19801 actgtcaaaa aacgtatctg ttttttcttt tgatcgcaca actaatttga aatttgggta
    19861 tctagattct ccaatagtaa tgttgttgac acttgacgat ttaacaggag atttttattt
    19921 agctgctgtt tctcaaggtg gatatctatt taaagattta gatacactta aacagttgct
    19981 taaagataat cacctagaag aagaaattag cggtataact aattacaagg attctgtgtt
    20041 aaatgaatta aatgaaacga aaacaaaaat gataataaca atagttacta ttattattaa
    20101 cgttttcatt cttttgatag ctactgtatt tgaaacaatt caatatttta gctggaataa
    20161 aaagcaacta ttattaagaa aaattcatgg ttattcatta ttcagcagta atgtacgtta
    20221 tttaacaatt tctatcttac tttctattat gttagcttac actacgcata ttttatttgg
    20281 ttcaaagata ttactattca taataatgtc tattgctatt attcaacatt tacttcaaat
    20341 tgcttatatt aaatatcttg aaaaatactt taaagattta atgagggaga tttaaacaat
    20401 gaaaagaact ttaattattg taacaattgt actattaatc atcatactta gtctgttatt
    20461 ggttagaaat gagcatttag atcgttttaa cccactgtta aaagaaaaag tatcttatgc
    20521 caaagttcca aaagataccc aggactatag aaatataact gtatactcta aaaatggaga
    20581 aaaaaagagt tataaattgg attttttagg ttatgatcct acaaaagaat atgtgaaagt
    20641 aaatcataaa gggaaatatg tgcgttcgat agaatacatt acaaaagata ttcctagctt
    20701 tttaaaatga ggtgaccgat ag
//
