LOCUS       CP049391               20639 bp    DNA     circular BCT 24-SEP-2020
DEFINITION  Staphylococcus aureus strain pt286 plasmid pER07993.3A.1, complete
            sequence.
ACCESSION   CP049391
VERSION     CP049391.1
DBLINK      BioProject: PRJNA470993
            BioSample: SAMN12331103
KEYWORDS    .
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 20639)
  AUTHORS   Caban,A.B., Pak,T., Kumaresh,A., Dupper,A., Chacko,K.,
            Sullivan,M.J., Altman,D.R. and van Bakel,H.
  TITLE     PathoSPOT genomic surveillance reveals prolonged under the radar
            outbreaks of nosocomial methicillin resistant S. aureus bloodstream
            infections
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 20639)
  AUTHORS   Caban,A.B., Pak,T., Kumaresh,A., Dupper,A., Chacko,K.,
            Sullivan,M.J., Altman,D.R. and van Bakel,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-FEB-2020) Genetics and Genomic Sciences, Icahn School
            of Medicine, One Gustave L. Levy Place Box 1498, New York, NY 10029,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 384.687488612836x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 02/28/2020 15:22:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.11
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 2,754
            CDSs (total)                      :: 2,672
            Genes (coding)                    :: 2,615
            CDSs (with protein)               :: 2,615
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 38 of 57
            Pseudo Genes (incomplete)         :: 12 of 57
            Pseudo Genes (internal stop)      :: 18 of 57
            Pseudo Genes (multiple problems)  :: 11 of 57
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..20639
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="pt286"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pER07993.3A.1"
                     /geo_loc_name="USA:New York City"
                     /lat_lon="40.7903114 N 73.9528738 W"
                     /collection_date="2017"
                     /collected_by="Mount Sinai Hospital"
     gene            join(20639,1..743)
                     /locus_tag="FPP49_13655"
     CDS             join(20639,1..743)
                     /locus_tag="FPP49_13655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="QNW09197.1"
                     /translation="MKSVKRLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESATEDKQKKESDNINFESKSDAQIVEILKNQINTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNAR
                     QNVDAQEKTYTTSPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAQREDVSANPND
                     NDSDIEEKSEETEAKKGFWSRLFGN"
                     /name="DUF536 domain-containing protein"
     gene            complement(962..1147)
                     /locus_tag="FPP49_13660"
     CDS             complement(962..1147)
                     /locus_tag="FPP49_13660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000466619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QNW09198.1"
                     /translation="MFGDQRQEATKYVIKEGYQDIYFLNKNGEWYYFEVRSVWRGKHII
                     RVKDGLLGWRKEIVTE"
                     /name="hypothetical protein"
     gene            1296..1367
                     /locus_tag="FPP49_13665"
     CDS             1296..1367
                     /locus_tag="FPP49_13665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="QNW09214.1"
                     /translation="MNEILVHIMTTAISGCLVTLFGY"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(1606..1947)
                     /locus_tag="FPP49_13670"
     CDS             complement(1606..1947)
                     /locus_tag="FPP49_13670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000761340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="QNW09199.1"
                     /translation="MKLAEAIKEQRELKGWSQEELANILKVSRQSVSKWESAKNYPSLD
                     ILIAMSDLFGISLEHLIKGDARFKKVILEGNYRESNRVPSIVDFLYDFWWLFFPVAGFL
                     VWAIHSFMG"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(2034..2894)
                     /locus_tag="FPP49_13675"
     CDS             complement(2034..2894)
                     /locus_tag="FPP49_13675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000145511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="QNW09200.1"
                     /translation="MTGETVVYKNEMNLVPLRRFTATEINLFFAMCNKLKEQDTNTLRL
                     SFDELKKLSNYSPETRNINRFANDLDNVYKKMLNLTIRYEDDDVIERFVLFNHYRIHKR
                     EQYLEISTSSNLKHILNSITNNFTKFELKEMTRLKSTYSKNMFRLLKQYKHTGYLKIHI
                     DDFKNRLDIPKSYRMTDINKNVFKPIIIELGSIFNNLTINKIKAKKGRKIEWIEFTFDA
                     EKRIHNKRQPQMSKIDKSRQYVRREKTPKWLEERSYEKQPQKDYDPQLEKEREDFLKQL
                     ELNWE"
                     /name="replication initiation protein"
     gene            2934..3242
                     /locus_tag="FPP49_13680"
     CDS             2934..3242
                     /locus_tag="FPP49_13680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001020849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="QNW09201.1"
                     /translation="MNIHSHLKTFIHNKLLYYQCQTIKGVQLFKTLLLCGKNTPFMWQK
                     HSFYVAKTLLLCGKNTPLGIEIPCCSRAEQAPKKVFKKIYKNILKSSRGLPIFHPKK"
                     /name="hypothetical protein"
     gene            complement(3277..4533)
                     /locus_tag="FPP49_13685"
                     /pseudo=""
     CDS             complement(3277..4533)
                     /locus_tag="FPP49_13685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331753.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid recombination protein"
                     /name="plasmid recombination protein"
     gene            complement(4771..5397)
                     /locus_tag="FPP49_13690"
     CDS             complement(4771..5397)
                     /locus_tag="FPP49_13690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000593102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="QNW09202.1"
                     /translation="MIKLENVFVKKGNKNILDGCNFNFEKGKSYALVGESGAGKSTLLN
                     IIAGFEDVSQGSIYIEDKLLKKKVDFYRYTLGYLFQNFALLENQTISQNLDLALKFKKN
                     KKDNMNLKKEVLKKVGLDLDIKRIVSSLSGGEQQRVALARLILKDPKIILADEPTGSLD
                     TKNGKIVIDLLLKLLDENKTMIVVTHDLELAKRFDVIVNISELRS"
                     /name="ABC transporter ATP-binding protein"
     gene            complement(5409..5720)
                     /locus_tag="FPP49_13695"
     CDS             complement(5409..5720)
                     /locus_tag="FPP49_13695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YxeA family protein"
                     /protein_id="QNW09203.1"
                     /translation="MKRTLIIVTIVLLIIIFSLLLVRNEHLDRFNPLLKEKVSYAKVPK
                     DTQDYRNITVYSKNGEKKSYKLDFLGYDPTKEYVKVNHKGKYVRSIEYITKDIPSFLK"
                     /name="YxeA family protein"
     gene            complement(5724..7658)
                     /locus_tag="FPP49_13700"
     CDS             complement(5724..7658)
                     /locus_tag="FPP49_13700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001670421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="QNW09204.1"
                     /translation="MKKFKLFLDFSTLLLISGLLFLFFFKENEEIIPESSNILTISNWD
                     KSNSKSKVLDVIESGAKNQNIQIIKSVKDFDNKKEFFVFNSKRNNSDFIRNKTSLLTPS
                     DLLNREIKGKYYIIGEHFNVEELTSELKKAGLTSEVEYINRNILFFELVIDNDLLVPFI
                     FLGVLYLLYFLYDRGYNLKFYAIQKLHGFSTTRIIFHNIHIKIIYWLVLTAIFFIANIL
                     IIHIANLELDFLMFIRRFIVLLFVFACITTLLWLISYSLLLKLSIPLILKGKKGYKFSI
                     FMGTFTKCIMVLILSFLLAQNLNAYTKLKNIYDSEKIWQKLDNYYTLEISPNIRNSEEK
                     QILETNIYNLIKKSEQLGGLLLKNNNIANPDKNNYIPENGNVFFINNNFLNFYKNINHD
                     FKMIDNHSDKINVFIPPRLQYQKSEIQKNHQGWIDFQKQQNKKVDVQVLSKNVSVFSFD
                     RTTNLKFGYLDSPIVMLLTLDDLTGDFYLAAVSQGGYLFKDLDTLKQLLKDNHLEEEIS
                     GITNYKDSVLNELNETKTKMIITIVTIIINVFILLIATVFETIQYFSWNKKQLLLRKIH
                     GYSLFSSNVRYLTISILLSIMLAYTTHILFGSKILLFIIMSIAIIQHLLQIAYIKYLEK
                     YFKDLMREI"
                     /name="bacteriocin-associated integral membrane family
                     protein"
     gene            complement(7733..8026)
                     /locus_tag="FPP49_13705"
     CDS             complement(7733..8026)
                     /locus_tag="FPP49_13705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000726503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="QNW09215.1"
                     /translation="MKKKFVSSCIASTILFGTLLGVTYKAEAATVHVAGGVWSHGIGKH
                     YVWSYYSHNKRNHGSTAVGKYSSFSGVARPGVQSKASAPKAWGGNKTFYSLH"
                     /name="lactococcin 972 family bacteriocin"
     gene            complement(8440..8973)
                     /locus_tag="FPP49_13710"
     CDS             complement(8440..8973)
                     /locus_tag="FPP49_13710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001823239.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="QNW09216.1"
                     /translation="MIVGYARVSSNDQNLERQLENLKTFCAEKIFTEKQSGKSIENRPV
                     LQEALNFLRMGDRFVVESIDCLGRNYDEVVGNPLLDKFMKDLIIQILAMVSEQERNESK
                     RRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRIIYHRVVEMLEEGQSISKIAKEVNIT
                     RQTIYRIKNDNDLI"
                     /name="recombinase family protein"
     gene            complement(9342..10187)
                     /gene="blaZ"
                     /locus_tag="FPP49_13715"
     ARG             complement(9346..10187)
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            10294..12051
                     /gene="blaR1"
                     /locus_tag="FPP49_13720"
     ARG             10295..12048
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="95.56"
                     /coverage="100.0"
     gene            12041..12421
                     /gene="blaI"
                     /locus_tag="FPP49_13725"
     ARG             12042..12418
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.21"
                     /coverage="100.0"
     gene            12685..13278
                     /locus_tag="FPP49_13730"
     CDS             12685..13278
                     /locus_tag="FPP49_13730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="QNW09208.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNQKDLNLLKTLYDNGTPI
                     KTIAEQWHVSRTTIYRYLNKLEDKEDEKQGEVSN"
                     /name="recombinase family protein"
     gene            13250..14693
                     /locus_tag="FPP49_13735"
                     /pseudo=""
     CDS             13250..14693
                     /locus_tag="FPP49_13735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000790716.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DDE-type integrase/transposase/recombinase"
                     /name="DDE-type integrase/transposase/recombinase"
     gene            14686..15501
                     /locus_tag="FPP49_13740"
     CDS             14686..15501
                     /locus_tag="FPP49_13740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019467708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="QNW09209.1"
                     /translation="MTKNQNFIETKEYKRFAEFCDACIKYQYIGICYGQPGVGKTLSSR
                     YYTNWDTIEKQVNHRGWEDLASKTTDDILSVDKIFYNAPAEKQTKLRNDLYSITAIIDL
                     GQKLHVVNKYGHEHSKHYSDMFKYIDLIIVDEIDRLKVQHLEQLRAIYDEHNLAMIFIG
                     MPGIEKKLSRYPQLYSRIGFAHEFDNLSKDETHHILEYKWQDLGFDLKLEDFTDYEAIT
                     TIIKITKGNFRLIHRLFAQIDRIMDINGLDKISTEVVETARDSLVIGIR"
                     /name="AAA family ATPase"
     gene            complement(15621..16595)
                     /locus_tag="FPP49_13745"
     CDS             complement(15621..16595)
                     /locus_tag="FPP49_13745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4062 domain-containing protein"
                     /protein_id="QNW09210.1"
                     /translation="MSNTKIKYQIFISSTYLDLIEERQAVVEAVLNSNNIPAGMELFNS
                     SSKSQWEIITQWINESDAVILLLGSSYGTIDSEENISYTEMEYNFAKSLGKPIYVFEMN
                     KASTESAEKSKKLDEFKTKVKENRLISPNINDISELKSKVSQTLMQSVPSEIKENSGWI
                     RVQDCGKNVKKLKKLDAIQRDLDTYDFLKEELYKIFMYVKTFYFQHTPFDDSYIEDIEN
                     YLLNYENNPHKSFMKIKVYDYKNFLKHLKNILILIKQGKKPLAQAGHFKLSFYEEDLKL
                     LQKNYKATLVDIKGLNKHFYKECDRCLKAYNIFIEGINKHLYE"
                     /name="DUF4062 domain-containing protein"
     gene            complement(16807..16899)
                     /locus_tag="FPP49_13750"
     CDS             complement(16807..16899)
                     /locus_tag="FPP49_13750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="QNW09211.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(17068..17415)
                     /locus_tag="FPP49_13755"
     CDS             complement(17068..17415)
                     /locus_tag="FPP49_13755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="QNW09212.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNQEGF"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(17434..18051)
                     /gene="cadD"
                     /locus_tag="FPP49_13760"
     ARG             complement(17438..18051)
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="99.51"
                     /coverage="100.0"
     gene            complement(19259..19568)
                     /locus_tag="FPP49_13765"
                     /pseudo=""
     CDS             complement(19259..19568)
                     /locus_tag="FPP49_13765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002483623.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            complement(19552..20228)
                     /locus_tag="FPP49_13770"
                     /pseudo=""
     CDS             complement(19552..20228)
                     /locus_tag="FPP49_13770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     ARG             complement(9343..10187)
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.8"
                     /coverage="100.0"
     Typing          complement(19055..19202)
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="81.333"
                     /coverage="100.0"
                     /evalue="2.96e-25"
     Typing          2..743
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="99.0"
                     /evalue="0.0"
     Typing          complement(2035..2894)
                     /name="rep_cluster_2214"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(4271..4533)
                     /name="MOBV"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="98.864"
                     /coverage="100.0"
                     /evalue="4.5699999999999996e-48"
ORIGIN
        1 tgaaaagtgt aaaaaggttg agtgaagaat taggggttag taagcaaacg atttttaata
       61 atattaagag attgaatata gagacaataa aacaggaaaa cacttcgttt attaaagaag
      121 ataccgatat agaaaaaatc attcaaagag taaatgaaaa taaaaagaaa tatggttttg
      181 aaagtgctac tgaagacaaa caaaaaaaag agtcggataa tattaatttt gaatctaaaa
      241 gcgatgctca aatagtagaa atacttaaaa atcagattaa tactttaaat aatcaaattg
      301 aaaaacaaga aagtcgtcat gaaacaacaa ttgaatttta cagaaaagag ttgcaagaaa
      361 gatcaaaatt gcttgagaat cagcaagttc tggcattaga gagtaataaa aagattcaaa
      421 aattagaaaa tcaattagaa aaagaaaaac accttaatta tccctttgat acatctacta
      481 acgctagaca aaacgttgat gcacaagaaa aaacatatac tactagtcct gtaaatatta
      541 accgagatca ggaagaaact aaagaaacag agattcaata taaggatata tctggaagtc
      601 aaagcgacga aagtacacaa ggtgaagaag cacaaagaga agacgtttca gctaatccaa
      661 atgacaatga tagtgatata gaagaaaaga gtgaagaaac ggaagctaaa aaggggtttt
      721 ggagtcgtct atttggtaac taattttaat taaaaaggta cgacaagttc ataaattagc
      781 cgtgcttttt tatgtgaatt gaacttctga taatcatcga ttatattaac caaacaaaaa
      841 gccataaatg cctatatgac ggcatttatg gctttttact ttcattatct tttatgcatc
      901 ttttatacat cgttgatttg acgcgttttc attcttttgc attggcaagt attttgtatc
      961 tttattcagt tactatttct tttctccaac ctaacaaacc atctttaact ctaataatat
     1021 gtttgccacg ccagacactt cttacttcga aataatacca ttccccgttt ttgttgagga
     1081 aataaatatc ttgataacct tctttaatga catattttgt agcttcttgt ctttgatcgc
     1141 caaacattat caatcccacc cttatattta tttatcttta atatataaca acatttatta
     1201 atattcatgt tatttcatgg aaggagagat ttgttataat gtgaaggtcg tctatctctc
     1261 agatgtcaat tcggcgtaga gaggaggtgc gatttatgaa tgaaattctt gttcacatca
     1321 tgacaacggc aatcagtggt tgtctcgtta cgttatttgg ttattagctc cataaacgtg
     1381 ataaaaaata atatagacga ttaaagccaa ttcaccaaaa aaccccgaac tacggcgaat
     1441 agttcggggt ttggtgcgtt tacaaacgaa attcttgtta cttttagtat atatttcata
     1501 ttgccttttg taaactcttc tattcttatc aatacatttc aaggtgtcgt aaaaatactt
     1561 tcctttttca tattgcctga tgtgcattaa attttgattt taaaatcaac ccatgaacga
     1621 atgaatggcc caaactaaaa atccggcaac aggaaagaaa agccaccaaa aatcataaag
     1681 aaaatcaact atggaaggta ccctgttact ctctctataa tttccctcta aaataacttt
     1741 tttaaaacgt gcatctcctt taattaaatg ctctaaagag attccgaata aatcgctcat
     1801 agcaatcaaa atatctaagg aaggatagtt tttggcactt tcccatttag aaacactttg
     1861 tctggaaacc tttaatatat tggctaattc ctcttgagac catcctttta attctctctg
     1921 ttcttttata gcttcagcta atttcataaa atcactcctt aactcaaact ataattaaaa
     1981 taattgaaaa gtcacgatac ttttagttaa ccaactcgca acgaaaagtt gcgttattcc
     2041 caattcagtt caagttgttt taaaaaatcc tctcgttctt tctctaattg tgggtcgtaa
     2101 tctttttgag gttgcttttc atatgaccgt tcttctaacc atttaggcgt cttttcacgc
     2161 ctcacatatt gtcttgattt atctatcttg gacatttgag gttgtcgttt gttatgaatg
     2221 cgtttctcag cgtcaaatgt gaactctatc cattcaattt tacgcccttt tttcgctttg
     2281 attttattga tagtaagatt attaaatata gaacctaatt caataataat aggtttaaaa
     2341 acatttttgt taatatcagt catacgataa gatttaggta tatctaaacg atttttaaaa
     2401 tcatcgatgt gaatttttaa atagcctgta tgtttgtatt gtttaagtaa tctaaacata
     2461 tttttagaat atgtagattt aagcctagtc atttctttta attcaaattt tgtaaaatta
     2521 ttagtaattg aattcaatat gtgttttaaa tttgaagaag ttgatatttc tagatattgt
     2581 tctcgcttat ggattctata atgattgaat aaaacgaatc tttctattac atcatcatct
     2641 tcatatctaa tggttaaatt caacatcttt ttatacacat tatctaaatc attagcaaat
     2701 ctattaatat tacgtgtttc tggactataa ttacttaatt tttttaattc atcaaaagac
     2761 aaacgtaatg tattagtatc ttgctctttt aatttattac acatcgcaaa aaataaatta
     2821 atttcagtag ctgtaaatcg ccttaatgga actaaattca tttcattttt atatacaact
     2881 gtctctcctg tcatgataca gcccccttta ttacgaacct aaaggagtat cgtttgaata
     2941 tacactccca tttgaaaact tttattcaca ataaactact ttattatcaa tgtcaaacca
     3001 taaaaggagt acaacttttt aaaacactcc ttttatgtgg caaaaacact ccttttatgt
     3061 ggcaaaaaca ctccttttat gtggcaaaaa cactcctttt atgtggcaaa aacactcctt
     3121 taggcattga aatcccttgt tgctctaggg ctgaacaagc ccctaaaaag gtttttaaaa
     3181 agatttataa aaatatatta aaaagttcga gggggctacc tatttttcat cctaaaaaat
     3241 aattaacctc aaacaaatgc atttaaatat ctatttttat aatgtataac catcttctct
     3301 atcttcttta aaaatgattt ctcgttcttg tgcttgatat ttcttcttaa agaactgttc
     3361 atcattgtta tctatcgtca ttacttcacg tattttagaa ttgtctaaat gattatcaat
     3421 atgatttatt agtgtatgat aacgctcttc tttcatcata cttttaatga ttttaaaaac
     3481 ttgattgaat aacttaagcg tataatttag ttctttatct ttcttttcat tctctgacaa
     3541 caaataatta taacgttgtg ctaaatcatt aaattcttca accagctttt cattttccat
     3601 atggacacta gtcaattcat taactaaact ttcattttgt ttctctgctt tttttaatga
     3661 cttcccactt ttaatacatt cataatcatc taatatcatc tgtgctgctt taatttgttt
     3721 agtgtatttt tcaaaatcag ttttagtaat tacaatattg cctgtttctt gcttctcttt
     3781 atgaaaccat ccacctacat ttttagtttt aatttcatac atgacactca gaagcttttt
     3841 aagcgtatct aatgattttt ggtagttttg tatcaattta tcattttctt gctttaaata
     3901 atcctctatt tgcttctagc gcatatgcat ttgtttatga tattctgttt tttgtttata
     3961 acggctaact tgatcatgtt tttcttttgt aagttgtcta gaaattcctc gttttaaatc
     4021 atagccttgc ttattaatat acgtattgaa tctatcttgg aattcggtta atgctttttt
     4081 attacctaca acttctttcg cacttaaacg tccatcttta gtaataggaa ctacgccata
     4141 atgcatatgt ggtgttatct catccatatg tactgtcgca tataaaagat tttctttacc
     4201 gtattcttct tccaagaacg ctttagcatg cttaaaaaac tattttgtct cttcttcaga
     4261 taattgatta aaaaacacat tatctgatgt aattaatcca tcaatatgtt taatggcatc
     4321 tgttctaatt ttgcgtttcc ctttataatt tttttcgatt ttctcatcaa tttttttatt
     4381 aaaatcaaac ttagtatcat tgactaaatc atagtttaaa tatgacttac ttaaatcaat
     4441 atctatattt tcataatttt tattttctct ttgaatacct cttgtatttg tttttgattt
     4501 cactttaaca actcgaataa ttgaataaga cataataaat caacttccac tgcatatgat
     4561 tataacacct aaacacagaa aagttttaac atactagact tattaaaaac caaataagtc
     4621 attaaaaacg tgtgctctgc gaggcttgtt ttttgtcatc ataaaaaagg actggaaaat
     4681 ccagtcctta aattaaaaaa ctcaaaagta atgactaatc atatttcata ttgttttttc
     4741 tctatgtatg gctataccta tcaatatttc ttaacttcta agctcagaaa tattgactat
     4801 gacatcaaat cgtttcgcaa gctctaaatc atgcgttacg acaatcatag ttttattttc
     4861 atcaagtagc ttcaataata aatcaataac tatttttcca tttttcgtat ctagtgaccc
     4921 agtaggttca tcagctaaaa tgattttcgg atcttttaat attaatcttg ccaatgctac
     4981 tctttgttgt tcaccaccgc ttagagaact aacaattctc ttgatatcta aatctaggcc
     5041 gacctttttt aatacttctt tctttaagtt catattatct tttttattct ttttgaactt
     5101 tagggctaaa tctaaatttt gactgattgt ttgattttca agtaaagcaa aattttgaaa
     5161 caaataccct aacgtatatc tataaaaatc gactttcttt tttagtaact tatcttcaat
     5221 atatatgctt ccttgtgata catcttcgaa cccagcgatt atgttaagta aagtagattt
     5281 tccagcgcca ctttctccaa ctaaagcata tgattttcct ttttcaaaat taaagttaca
     5341 tccgtctaaa atgtttttat tacctttttt tacaaaaaca ttttcaagtt ttatcactat
     5401 cggtcacctc attttaaaaa gctaggaata tcttttgtaa tgtattctat cgaacgcaca
     5461 tatttccctt tatgatttac tttcacatat tcttttgtag gatcataacc taaaaaatcc
     5521 aatttataac tctttttttc tccattttta gagtatacag ttatatttct atagtcctgg
     5581 gtatcttttg gaactttggc ataagatact ttttctttta acagtgggtt aaaacgatct
     5641 aaatgctcat ttctaaccaa taacagacta aatatgatga ttaatagtac aattgttaca
     5701 ataattaaag ttcttttcat tgtttaaatc tccctcatta aatctttaaa gtatttttca
     5761 agatatttaa tataagcaat ttgaagtaaa tgttgaataa tagcaataga cattattatg
     5821 aatagtaata tctttgaacc aaataaaata tgcgtagtgt aagctaacat aatagaaagt
     5881 aagatagaaa ttgttaaata acgtacatta ctgctgaata atgaataacc atgaattttt
     5941 cttaataata gttgcttttt attccagcta aaatattgaa ttgtttcaaa tacagtagct
     6001 atcaaaagaa tgaaaacgtt aataataata gtaactattg ttattatcat ttttgttttc
     6061 gtttcattta attcatttaa cacagaatcc ttgtaattag ttataccgct aatttcttct
     6121 tctaggtgat tatctttaag caactgttta agtgtatcta aatctttaaa tagatatcca
     6181 ccttgagaaa cagcagctaa ataaaaatct cctgttaaat cgtcaagtgt caacaacatt
     6241 actattggag aatctagata cccaaatttc aaattagttg tgcgatcaaa agaaaaaaca
     6301 gatacgtttt ttgacagtac ttgcacatct acttttttgt tttgttgctt ttgaaagtca
     6361 atccatcctt ggtgattttt ttgaatttca gatttttgat attgtaacct tggaggaata
     6421 aacacgttta ttttatccga atgattgtca atcattttaa aatcatgatt tatattttta
     6481 tagaaattca gaaaattgtt attgataaaa aagacattgc cattttcagg aatgtaattg
     6541 tttttatcgg gattggctat attattattc tttaaaagca atccaccaag ttgttcgctt
     6601 ttcttaatta aattgtatat attagtttct aaaatttgtt tttcttctga atttctaata
     6661 ttaggagaaa tctctaatgt atagtaatta tctaactttt gccagatttt ttcagagtca
     6721 tatatattct ttaacttcgt ataagcattt aaattttgtg ccagtaaaaa agatagtatt
     6781 agcaccatga tacatttggt gaaggtaccc ataaatattg aaaacttata tccttttttc
     6841 ccttttaaga ttaatggaat acttaacttc aaaagaagac tatacgaaat cagccacagc
     6901 aatgtagtaa tacaagcaaa aacaaaaagc aacacgataa atctacgaat aaacattaag
     6961 aaatccaatt ctaaattggc tatatgaatg attaatatat tagcaataaa gaaaatagcg
     7021 gtaagtacta gccaataaat gatttttata tgaatattat gaaaaataat gcgtgtagtt
     7081 gaaaagccat gtagcttttg aatagcataa aatttcaaat tatatcctct gtcatataag
     7141 aagtacaaaa gatataatac gcctaagaat atgaaaggca ctaataaatc attatctatg
     7201 actaattcaa aaaataatat gtttctattt atgtattcaa cttcagatgt taaaccagct
     7261 ttttttaatt cactcgtaag ctcttctaca ttgaaatgtt caccaataat ataatacttt
     7321 ccttttatct ctctgtttaa taaatctgat ggagttaaaa gtgatgtttt attacgtata
     7381 aagtcagaat tatttcgttt tgagttgaaa acaaaaaatt cttttttatt atcaaaatct
     7441 ttaacggatt taattatttg tatattttga tttttggcgc ctgattcaat gacatctaac
     7501 acttttgatt tactgttaga tttatcccaa ttagagattg ttaaaatatt ggaactttca
     7561 ggtataattt cttcattttc tttgaagaaa aataaaaata atagccctga aattaataat
     7621 aaagtactaa aatctaaaaa taatttgaat tttttcatat tgcctctttc aagagaatag
     7681 acagaattaa gtttacttaa ttctgtctat tctccttaat taatatatgt aattagtgaa
     7741 gactataaaa tgttttgttt ccaccccaag cctttggagc agatgcctta gattgaacac
     7801 caggtcgagc aacaccacta aaagatgaat atttccctac tgctgttgaa ccatgatttc
     7861 ttttattgtg actataataa gaccatacgt aatgttttcc aataccatgg ctccaaacac
     7921 caccagctac atgtactgtt gcagcttcag ctttataagt tacacctaat aaagtgccga
     7981 ataagattgt actagcaata caactagaaa caaatttctt tttaataaaa acacctccat
     8041 ttaatattct ttatttatta tagcaaaaat aaataaaata gagaatgagt aaaaataatc
     8101 taaaagtgtt ttttctgctc tgttgcttgt tttgttcatc tatatataat attaattcta
     8161 ttatccttaa attaactatc attaaacaac gatatgacaa tgtataataa atacaatttc
     8221 actacctata attcaacatt atataaacta aagtatttca aataattaac tgtattaata
     8281 ctctcatcat gattgcgtta taaacgttcg ttaatgagaa aaagagagag catatttacg
     8341 ctctcttttc ttgtcttatt attaaaaact cataatagat tataatcatc tgttttgaga
     8401 cgctgtgaga agctctcagt tgcattgaaa caaagtttat taaatcaaat cattatcgtt
     8461 tttaattctg taaatcgtct gccttgttat atttacttct ttcgcaattt tactaattga
     8521 ttggccttct tctaacattt ctacaacgcg atgataaata atacgtttct gtggatcttt
     8581 agcatttggt gaataaagta aggggcgccc tttatatacg cctttttcct tcgcaacttg
     8641 aattccttgc gcttgtcgac gtttactttc atttctctct tgttctgaaa ccattgctaa
     8701 tatttgaata attaaatctt tcataaactt atccagtaat ggattgccaa ccacttcatc
     8761 ataattacga cctaaacaat caatggattc tactacaaac cgatctccca tcctcaaaaa
     8821 gttaagtgct tcttgaagta ctggtctatt ttcaatagat ttcccagact gtttttctgt
     8881 aaatattttt tcagcacaaa acgtctttaa attttcaagt tgtctttcta aattttgatc
     8941 gttcgatgat actctcgcat agccaacaat cattgatttc catctcataa ttaatataca
     9001 ccctaatcat acgtttcagt tactataaat tcaacaatta tgtcactttg cttgatatat
     9061 gagaattatt taaccttata aatgagaaaa aagcaacgca ctttaaataa gatacgttgc
     9121 tttttcgatt gatgaacacc tataattaaa ctattcatct attatttatg attttttgta
     9181 tatacaatat ttctagtttg ttaaagagaa ttaagaaaat aaatctcgaa aataataaag
     9241 ggaaaatcag gttttgatat caaaattata catgtcaacg ataatagaaa atataataca
     9301 aactataaga tgttatcagt atttattatg catttagaat attaaaattc cttcattaca
     9361 ctcttggcgg tttcacttat caacttatca tttggcttat cacttttatt gtctttattc
     9421 gtaaaaatga ctaaaacaat aggttcagat tggcccttag gataaacaaa agcaacatca
     9481 tttctagaag catatgttat tgcttgacca cttttatcag caaccttata gtcttttgga
     9541 acaccatctt taattaaagt gtctccgttt ttattattaa acattaaatc aagtaagaaa
     9601 tttttatttt ttttgcttaa ttttccattt gcgataagtt tatttaaagt cttgccgaaa
     9661 gcagcaggcg ttgaagtatc ttttttgctc tttggcgaat agtaatttaa ttctatctca
     9721 tatctaactg gatttgttac tttatctcct agttctttta gacgttgttt aacttttttg
     9781 attccaccga tttcttttat aattttattg tttgctgtat tatcactata tgtcattgaa
     9841 gcctcaataa gttcttttaa agtgatgtct tttcctacat atttttctaa aataggagaa
     9901 taagcaacta tatcatcttt gttaatatgt acttttttat ttaacttatt ataaggtact
     9961 tgttctaaca aaatagcact atttatcgct tttgaagtcg aagcataggc aaatctctta
    10021 tctgaattaa attttacttc cttaccactt ttagtatcta aagcataaac accaatatga
    10081 gcattatatt ttttttctaa atcatttaac tctttggcat gtgaactgtt tgaattacat
    10141 gcacttaaaa ctaaagccat tacaattaaa aatattaact ttttcaaaat aaaccctccg
    10201 atattacagt tgtaattttt acaaaacaat aatattacaa ttgtaatatt gatgtcaatt
    10261 gtttattata aatatttgaa agaaggtgtc aaaatggcta aattactaat aatgagtgta
    10321 gtaagctttt gttttatatt tctattgtta gtatttttta ggtacatatt aaaacgctat
    10381 tttaattata gtttaaatta taaagtttgg tatctaactg tgcttgctgg attaattcct
    10441 tttatcccaa ttaaattctc ttttataaaa tttaataatg tgaataatca agcgcccaca
    10501 gttgaaagta agtcacacga cttgaaccat aacataatta ccaccaaacc tgttcaagag
    10561 ttcgcaacag atatccataa gtttaattgg gattcaattg ataatatctg cacagttatt
    10621 tggatagttt tagttattat tttaagtttt aaatttttga aagccttatt atatcttaaa
    10681 tatttaaaga aacagtcact ttatctaaac gaaaatgaaa aaaataaaat agatacgata
    10741 cttttcaacc atcaatataa aaaaaatatt gtgattcgaa aagcagaggc tattcaatct
    10801 ccaataactt tttggtatgg gaaatatatt attttgattc ctagttcata ttttaaaagt
    10861 gtaattgata aaagactaaa atatataata ctgcatgaat atgctcatgc taaaaataga
    10921 gatactttac atttaattat ctttaatatc ttctctatta ttatgagtta caatccatta
    10981 gtacatattg taaaaagaaa gataattcat gacaatgaag tagaagccga tagatttgtc
    11041 cttaataata ttaacaaaaa tgaatttaaa acttatgcgg aatctattat ggactccgta
    11101 ttaaaaacct catttttcaa caaaaatata ttaagccatt catttaatgg taaaaaatca
    11161 ttactcaaaa atagattaat taatataaaa gaagccgatc tgaaaaagca gtcaaaatta
    11221 attctaattt ttatttgtat ttttactttt tttatcatga taattcaaag ccagttttta
    11281 atggggcaat ccttaactga ttataattat aaaaagccct tacaaagcga ttaccaaatt
    11341 ttagatgaaa gtaaaaattt tggttcaaat agtggatctt tcgttatgta cagcatgaag
    11401 aaagacaaat actatattta taatgaaaaa gaaagtagaa aaagatattc tcctgattca
    11461 acttacaaaa tttatttagc actgtttgga cttgaccgtc atattataag tgataaaaat
    11521 tcacgtatgt catggaatca taaacattat cttttcgagt cttggaataa ggaacaagat
    11581 ttaaatacag caatgcaaaa ttcagttaat tggtacttcg aacgtattag taatcaaata
    11641 ccaaagaact atactgcggc tcaactcaag caattaaatt atggtaatga aaatttggga
    11701 agttataaaa gctattggat ggaagatagt ttgaaaatat ctaatcttga acaagtaata
    11761 gtttttaaaa atatgatgga acaaaataac cattttagta aaaaagcaaa gaatcaatta
    11821 tcttcttcat tattgattaa gaaaaatgaa aagtatgaac tgtatgggaa aacaggtaca
    11881 ggtatagtaa acgggaagta taataatggg tggtttgtag gttacgtaat tacaaatcat
    11941 gataagtatt attttgctac acatttatca gatggaaacc cgtctgggaa aaatgctgaa
    12001 ttaataagtg aaaaaatatt aaaaggaatg ggtgttttaa atggccaata agcaagttga
    12061 aatatctatg gctgaatggg atgttatgaa tataatatgg gataaaaaat cagtatcagc
    12121 taatgaaatt gtagttgaaa ttcaaaaata taaagaagtt agtgataaaa cgattagaac
    12181 attaatcaca agactatata aaaaagagat tataaaacga tacaaatcag aaaatattta
    12241 tttttactca tcaaatatta aagaagacga tattaaaatg aaaactgcta aaacctttct
    12301 taataaactg tatggagggg atatgaaaag tttagtgttg aattttgcga aaaatgaaga
    12361 attaaataac aaagaaattg aagaattgcg agatatttta aatgatatta gtaaaaagta
    12421 attagaggta tgtttcaaac ataatacata tgtaaactat gcttgactct tattaaatta
    12481 gttttgttaa tgacatttaa aatatattat taaagatgag agtgtacaga aaataaccat
    12541 tttctgtaca ctcttctttt atgtctaaat aagtaagaat tacataggat tatgtgttca
    12601 aaaacccaac aaaaaatcta tgttcataaa agaccttgta attaagttat ggtacactga
    12661 agatgtatat aggaggtttg tattttgaaa ataggttatg caagagtttc aactggatta
    12721 caaaatttaa atttacagga ggatcgatta aatacatatg gttgtgaaaa gatatttaat
    12781 gaccatatga gtggttcaaa aagtaaaaga cctggtttag ataaagcaat tgaatttgcg
    12841 aggtcaggag atacgattgt tgtttggaga ttagatagat tgggacgtaa tatggaggat
    12901 ttaatcacat tagttaatga gcttaacgaa cgaggtgtaa gtttccatag tttagaagaa
    12961 aatataacaa tggataaatc aagttcaact ggacaattat tatttcattt attcgcagca
    13021 tttgcagaat ttgaacgtaa tttaatttta gagcgttctt cagctggccg aattgcagca
    13081 cgtgctagag gccgatatgg aggcagacca gaaaaattaa atcaaaaaga tttaaactta
    13141 cttaagaccc tttatgataa tggcacgcca attaagacaa ttgcagaaca gtggcatgtt
    13201 tcacgtacaa caatttatcg ttacctcaat aaattggagg acaaggaaga tgaaaaacaa
    13261 ggagaagtat ctaactaatt tttctgaagc caaacgtaaa aaagctactc aaaagtacaa
    13321 tattataaaa ccttttatcc taggcgaaca atctttatca agtatttcta aaagtaaagg
    13381 gattgcgtta agcacccttt ataggtggaa taagtcatat aaagaacaag gacttaaagg
    13441 actaatctat gcgacaagag ctgataaagg aacacgtaaa atagaaccaa agataattga
    13501 tgaaattgaa cgccttgcgc ttatgaataa aagaaatagt atagccacaa ttcataggaa
    13561 aatcactaat tactgtaaag aaaataattt tgatatacca agttataaac aaatttatag
    13621 tgttattaaa gcgatgccta agtctgttat tgatttctct catcagggtg aaaaatacta
    13681 tcaaaataag tacgatttaa tacaaattag agaatcctcg agacccaatg aaatatggca
    13741 agcagaccat actttgctag atatctttat attagaccaa aaaggtaata tcaatagacc
    13801 atggctaact attattatgg atgactatag tcgtgcaatt gcaggctatt tcttaagttt
    13861 tgatgccccc caatgctcaa aacacagcat taacactaca ccaagcaata tggaataaaa
    13921 atgataccaa ttggccagtg tgtggtatac ccgaaaaatt ctacacagat catggaagtg
    13981 actttacttc acatcatatg gaacaagtcg ctattgattt gaaaattaac ttgatgtttt
    14041 cgaaagttgg tgttcctcgt ggtcgtggaa aaatagaacg attctttcag acagttaatc
    14101 aaactttctt agaacaactg cctggatata taaacaataa tgatactcct agtaatctaa
    14161 taaattttca caattttgaa gaaaaattac gttacttttt aattgaagat tataatcaaa
    14221 aagaacatag tactattcat accacgccta tcagtcattg gaatagtaat cactttttcc
    14281 ctaatatgcc aagtagctta gaacaacttg atttattatt gttggaaata cctaaatcta
    14341 gaaaagttca ttcagatggc attcattttc aaggttttcg atacagtaat actaatctag
    14401 aagcttatgt aggtgaatat gtactgattc gttataaccc aaatgatatg gctgaaatac
    14461 gtgtgtttta tagagatgaa tttctttgta ctgctatatg tccagaaata gctgattact
    14521 ccatagatat aaaagacata cagcacgctc gtagtcagag aagaaaacac ttaaaacaaa
    14581 atattgctag tccaagtacc acggaattaa ttaaggaaga aaaaaattgt ggttattcac
    14641 ctcaagaaac gactaaaaac gtcaaaaaat taaagagata tcgtaatgac taaaaatcaa
    14701 aatttcattg aaacgaaaga gtataaacgc tttgctgaat tttgtgatgc ttgtattaaa
    14761 tatcagtata ttggtatatg ttatggtcaa cctggtgtcg gaaaaacttt atcgtctagg
    14821 tattacacaa attgggatac tattgaaaaa caagttaacc atagaggttg ggaagattta
    14881 gctagtaaaa cgaccgatga catactatcg gtggataaaa tattttataa tgcaccagca
    14941 gaaaaacaaa ctaaattaag gaatgattta tatagtatta ctgcaatcat tgatttgggt
    15001 caaaaattac atgttgtaaa taagtatgga catgaacata gtaaacatta tagtgatatg
    15061 tttaaatata ttgatttaat tatagtagat gagattgatc gccttaaagt gcaacattta
    15121 gagcaattaa gagctattta tgatgaacat aatttagcaa tgatatttat tggtatgccg
    15181 ggtatagaga aaaaactatc tcgttatcct caactatatt cgcgtatagg ttttgcgcat
    15241 gaatttgata atctaagtaa agatgagacg catcatatat tagaatataa gtggcaagac
    15301 ttaggatttg atttaaaact cgaagacttt actgattatg aggcaataac gacgattatt
    15361 aaaattacaa aagggaattt taggctgatt catcgtttat ttgcgcagat agacagaatt
    15421 atggatataa atggtttaga taaaataagt acagaagttg tagaaacagc tagagatagt
    15481 ttagttatag gtattcgata atagaaaaag caacgcattt taatatagtg cgttgctttt
    15541 ctcatttatt aggtaaagtc attctcatat atcgagtaaa gtgacaacaa ttatatatgt
    15601 atgattaggg tgtacttata tcattcatat aaatgtttat ttataccctc aataaaaata
    15661 ttatatgctt ttaagcacct atcacattcc ttataaaaat gtttattcaa tcctttaata
    15721 tcgactagcg tagccttata atttttttgt aacaatttta aatcctcttc gtaaaagctt
    15781 aatttaaaat gaccggcttg agctaatggc ttttttcctt gtttaattaa aatcaatatg
    15841 ttttttaaat gttttaaaaa gtttttataa tcataaactt ttattttcat gaatgattta
    15901 tgtggattat tttcataatt tagcaggtag ttttctatat cttcaatata actatcatca
    15961 aatggtgtgt gctggaaata aaaagttttt acatacatga atattttata aagttcttct
    16021 ttcaaaaaat catatgtatc taaatctctt tgtatagcat ccaatttttt taattttttt
    16081 acatttttac cacaatcctg tactcttatc catccactat tttctttaat ttcactaggt
    16141 acactttgca ttaaagtctg agatacttta ctttttaatt ccgaaatatc attaatattt
    16201 ggactaatta gtctattttc tttaactttt gtcttaaact catctaattt tttagacttt
    16261 tccgcggatt cggtagatgc tttattcatc tcaaaaacat atataggttt acctaaagat
    16321 ttagcaaaat tgtactccat ttctgtatag ctaatatttt cttcactatc aattgttcca
    16381 taactagaac ctaacaataa tatcactgca tctgattcat tgatccattg tgttattatt
    16441 tcccattggc ttttactact tgagttaaaa agttccatac ctgctggaat attattactg
    16501 tttaaaactg cttctactac tgcttgacgc tcttctatta aatctaaata agttgatgaa
    16561 ataaaaattt gatatttaat tttagtatta ctcatatatg ctcctttaat aaaaaatcaa
    16621 tttacataaa tatatcatat gataatatcc aaaaagacta cttaaaatat tatctttttg
    16681 cattcctcta ctaaccagtg ttataatcta gataacgaaa atgattaaca attaatgcac
    16741 caatccccac actactgcaa tagtgtgggg attttttcga tgctggctta taaagtcgcc
    16801 tattaattat ttgttgcgtt tactaagcca ataagtataa tacgcaacag cacagccact
    16861 gatgactggt gctatgatgt gaacgaaaat gattagcaaa gtaatgcacc tcctctctgc
    16921 gtctgaattg acgcctgaga gataggcgac ctgtatatta tatcatctcc gaatatacga
    16981 tgatagataa cttccgataa gtcgtcttat gttatataac tttgtttttt atagtatcaa
    17041 gacaagaaga aactcgtttc actcgtttca aaaaccctcc tgatttttag agaaaaactc
    17101 tcttatttca tcgtctttaa taaaataata tgccatcttt ccatctttat aaaaatcaag
    17161 tacctcattt ttatataaaa gccttaaatg atgtgaagtt gaagcaacac tcattttcaa
    17221 tatcaaagaa atatcacaaa cacacaactc atcttcttta atcaaagata atatgatttt
    17281 caatttcttc tcatcacaaa ttttttctaa aatgttaagt aatttcttag atttatcatc
    17341 ttctaaaaaa cttaaagcat tgttaacttt atcctcatgt acacagatca catcacaagt
    17401 attttcataa ctcatataaa atcacaccct aaattaaaat ataaatccta aaattgtttg
    17461 aatagtgtca ttttcaataa taataaataa acctaaagct atataaatga tagccataat
    17521 ccaacgacta aatttctcaa caatttctcc aattcctggg atattagcta atttttgtgc
    17581 agtaaacacc aagaagaaaa ttaaaattaa aaagacaaac agagtaagta ataaattagt
    17641 aacacttaat gtcacaaaat aaggaacaaa taaaccaata ttatcggcgc cacaacttgc
    17701 tatcgtaaca attgcaaccg taccaactaa tttagacaat cctttttcat tcaattcttt
    17761 tttagctctc ttttctcctt cacaatcatc ataaatagcc actttaattc caagataaat
    17821 tggtattaaa cccaataaac ctaatatcca cttttctgga acataattta atacaaaagc
    17881 taaaaacaaa ctaactaata ttaaaataat agaccctaaa tattgaccaa cataaatatt
    17941 tctatattct tttctagtct ttgctctagc aaaaaatatt aataaaatta ctaataaatc
    18001 aactgctgta gcaatataaa gaacagcagc agcaacaacc gtttgaatca taatacacct
    18061 cattcaaaaa tatttttgaa tgtattataa cttatatttt taaataatca taggtgcttt
    18121 attccaattg ctttattgac gttgagcctc ggaaccctta acaatcccaa aacttgtcga
    18181 atggtcggct taatagctca cgctatgccg acattcgtct gcaagtttag ttaagggttc
    18241 ttctcaacgc acaataaatt ttctcggcat aaatgcgtgt ctatgcgtag acatggagac
    18301 acttcagaat tatggagtga ttacatgagt ttaactattt ttctttattc agttttagga
    18361 agtttattag caaattatat ctacgaaaaa tcttcaaaat aaataacttt ttcggttcta
    18421 ctttgtacac tttatctacc tggtagacct aattgttatt gctttacagg tctaaaattc
    18481 gtcgttataa tctagttaaa tcccgtaagg gcgcacttat acgtcggata aatcgacatg
    18541 tgcaaaaacg taatcgacct tcgtcgattt ttttatttca aaattaaaga aacggcttga
    18601 gatattccga gcagttataa aaattaattt gcgttgaata ttgctactac attcttgaaa
    18661 aagtgatgta gatttatagc ccataacttt tttgaattac atcgacgata cggcgtcgaa
    18721 agaaaaagct acctcacttt atctgggggg cttttatttt ttatgccctt attttgaatt
    18781 ttaagagggc attttaaaga tttaggggtg attcatatag ttttatctaa aacttatata
    18841 cgcttttaaa acgcaaatat gagccaaata aatatatgct attttcaaaa acaaaaattt
    18901 gagcaaaaac aataactatt ttttagacac tgcccattta catgcaaatt aaaaattagc
    18961 ataaaattct ttaaaacttc cccacgttct tctaaattcc tgcagggctt ttcttatcaa
    19021 aaacttagaa attttaattt aactctaaaa tctccgtaag agcataaggg aaatttgtcc
    19081 ccatcaatga atgggggatc tggcaaagcc agatatttca aggcttcgaa aatgtttttg
    19141 tgtggggtca taaaaagctc aagtgtcaca cttttgtgac actacataca gcatttgtca
    19201 caaaaataag acagcacttt ttttacaaaa aagtaataaa aaaagacatc agttatcact
    19261 aatgccttaa ataataattt tgcttttcaa aattgccgta atcgaatgtg ccttttcttc
    19321 ttcatttgct attttatctt catcacttgt attaattaaa ttgccatctt cagcatcgtc
    19381 taagtttaaa attttatgtt tttatttaag caatccacca taacttaaca tacgttttcg
    19441 atacaaatct ttttctagat cactgacaat ttcttgattt tttcatcgct atcagttaaa
    19501 aagtcagatg atttaacgaa atattttgat gtatctttga ttgttataaa atcatttgaa
    19561 tgattgatta aagatattat attgtttcat gtttttacgg cgcatataaa gtgcatgtgt
    19621 ttcttcaaat tcagttaaaa ttgtttgcat taaataacct tgcattgact tgaatgatta
    19681 ctaatttcat tttcggactc tatatcattc aagtcattca tatcatttat ttcagtattg
    19741 ttagattcag tatagctaag ttcagtatca ttagattctg ttttatcgac ttcttgaagt
    19801 cggtttttcc gacttccttg ccattgctgc tctcaacagt gttttcttgc ttttgaattt
    19861 tataaatatc atcttctgtt acttctggtt taactaaata aagtttattt gtcttattta
    19921 aaccttgtct ttcttgtagt agtaattcgg cttcaattaa gttctttctt tattttaatt
    19981 actttatctt ttttacaatt taatatattt tgtgggtttt catttttgta ataaaaataa
    20041 atattacctg ttttagaatc aacccaacca tttttaattg ataaatctaa acgatctcta
    20101 agaatacccc atgccatttt tgcatcattg gataacttga tatatttagg atttgtaaaa
    20161 aatactttcg gtatttgata aaacttttct ctgtattcct catttatgtt gtaaagttta
    20221 attgacataa taaaaacctc tttccgaatt ttagtttggt aagaggtaat aaaacgctta
    20281 cattttttgt gtttatttaa taatctaggt gcttgcacta agatattatt cattatataa
    20341 tctaagtatc gaaaattata taaataaaca gtttctaaac gttttattac caaaccccga
    20401 ctattaccag tagttggggt ttttgttata ttaaggttat tatagcactt tgaataaact
    20461 taaaaaaggg aaaatatagg tttataaacc tttgataaac accataaacc ctttacaaac
    20521 ccttgataaa aaggttggcg aatttatatt tttatttgtc gattacttta ttattaatcg
    20581 ttataagctt ataatatttt actaagggtt tataaacatt ttataaaggg ttgatgata
//
