LOCUS       CP046970               10060 bp    DNA     circular BCT 06-FEB-2023
DEFINITION  Klebsiella pneumoniae strain WCHKP115016 plasmid p2_115016, complete
            sequence.
ACCESSION   CP046970
VERSION     CP046970.1
DBLINK      BioProject: PRJNA353728
            BioSample: SAMN09688132
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 10060)
  AUTHORS   Hu,Y., Liu,Y., Liu,L., Feng,Y. and Zong,Z.
  TITLE     The complete genome of Klebsiella pneumoniae strain WCHKP115016
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10060)
  AUTHORS   Hu,Y., Liu,Y., Liu,L., Feng,Y. and Zong,Z.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-DEC-2019) Center of Infectious Diseases, West China
            Hospital, Sichuan University, Guoxuexiang 37, Chengdu, Sichuan
            610041, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 12/17/2019 14:55:13
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.10
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 5,698
            CDSs (total)                      :: 5,577
            Genes (coding)                    :: 5,466
            CDSs (with protein)               :: 5,466
            Genes (RNA)                       :: 121
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 10
            Pseudo Genes (total)              :: 111
            CDSs (without protein)            :: 111
            Pseudo Genes (ambiguous residues) :: 0 of 111
            Pseudo Genes (frameshifted)       :: 38 of 111
            Pseudo Genes (incomplete)         :: 72 of 111
            Pseudo Genes (internal stop)      :: 16 of 111
            Pseudo Genes (multiple problems)  :: 15 of 111
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..10060
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="WCHKP115016"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="p2_115016"
                     /geo_loc_name="China: Chengdu, Sichuan"
                     /collection_date="2018"
     gene            join(9977..10060,1..195)
                     /locus_tag="DVJ24_28340"
     CDS             join(9977..10060,1..195)
                     /locus_tag="DVJ24_28340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014542884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribbon-helix-helix protein, CopG family"
                     /protein_id="WCN72462.1"
                     /translation="MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEK
                     RSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWGTENEQDAPPCHR"
                     /name="ribbon-helix-helix protein, CopG family"
     gene            183..497
                     /locus_tag="DVJ24_28345"
     CDS             183..497
                     /locus_tag="DVJ24_28345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001136729.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WCN72463.1"
                     /translation="MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKT
                     LPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDREMDQIVIVTVRHQKESGYPGADSL
                     "
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            661..1089
                     /locus_tag="DVJ24_28350"
     CDS             661..1089
                     /locus_tag="DVJ24_28350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WCN72464.1"
                     /translation="MAKTLLNLSQAAQAAGITRRTLYNHVKQGKVTVSRDGKNNPVVDV
                     SELIRVYGNVNIPEKQIPGISHRENTQKNFPQEQLLAMQKELADLRQAVTLMLEDKTSR
                     EEERRQHDDERRKLQAEVDRLTTELTQKKKRFWSGWFS"
                     /name="hypothetical protein"
     gene            1115..1294
                     /locus_tag="DVJ24_28355"
     CDS             1115..1294
                     /locus_tag="DVJ24_28355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WCN72465.1"
                     /translation="MTKQEKTALNMAKFIKDQSLLLLEKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(1321..1851)
                     /locus_tag="DVJ24_28360"
     CDS             complement(1321..1851)
                     /locus_tag="DVJ24_28360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WCN72466.1"
                     /translation="MALYMVFIEDVEDKDGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGENPQWERDKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIEVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(1858..2589)
                     /locus_tag="DVJ24_28365"
     CDS             complement(1858..2589)
                     /locus_tag="DVJ24_28365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WCN72467.1"
                     /translation="MTLEQYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRAKYPVDGRQVSVWGLTPHGVAFSFDEDEPLTDVIPFQP
                     SRVSAAQLPHRLAVQSLRLSMEGRGATGWRYLHRMALKGMKVPDALAELDGRTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRRANGIDEIWYICPDRPTLVRVQRAILAVDEIVNPQTGEA
                     RKTVELDRERLFACFKFMTTE"
                     /name="hypothetical protein"
     gene            complement(2589..4553)
                     /locus_tag="DVJ24_28370"
     CDS             complement(2589..4553)
                     /locus_tag="DVJ24_28370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WCN72468.1"
                     /translation="MFNTDSLAWQWHIPELARQIYPWVSWLYREYYSLAGFFLVIGLFF
                     GLAELWAGRMRFVGLSHKARREYADRYKRDNNRTVPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLV
                     AGVLLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSTEQARKQQAVFLGKDEQGQPVLVPRDTWRKTNIQILGLPGSGKSAMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLV
                     AGFNLSETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     KLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFRRWPHASIMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPADFV
                     KTTVLDNTPIRWFYRAASQESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARLAFSSPLRVERREISLKTFPVLAKTDPLAEY
                     LPPADGGGPKADDDFAGLY"
                     /name="TraM recognition domain-containing protein"
     gene            complement(6037..6186)
                     /locus_tag="DVJ24_28375"
     CDS             complement(6037..6186)
                     /locus_tag="DVJ24_28375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lysis protein"
                     /protein_id="WCN72469.1"
                     /translation="MKKVKTIFLFILIVAGFLLAACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="lysis protein"
     gene            complement(6271..6528)
                     /locus_tag="DVJ24_28380"
     CDS             complement(6271..6528)
                     /locus_tag="DVJ24_28380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="WCN72470.1"
                     /translation="MGLKLRLTWFDKKTEEFKGEEYSKDFGDDGSVIESLGMPLKDNIN
                     NGEFDLKKEWVPLLQPFFKNQIKPDVDNCYIAFDYRDGNW"
                     /name="cloacin"
     gene            complement(6538..8223)
                     /locus_tag="DVJ24_28385"
     CDS             complement(6538..8223)
                     /locus_tag="DVJ24_28385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="WCN72471.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IMTSLPADAVTETPASTLPLDQATVRVRQRVVDVVKDERQHIAVVAGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPTAKAPPKGIVAEKGDSRPAGFTAGGNSREAVIR
                     FPKETGQKPVYVSVTDVLTPAQVKQRQEEEKRRQQAWDAAHPEEGLKRDYDKAKAELDA
                     EDKNIATLNSRIASTEKALPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQASLNAMNESLSRDKAALTGAMESRKQKEKKAKDAENKLNE
                     EKNKPRKGTKDYGHDYHPVPKTEDIKGLGELKRGDPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="cloacin"
     gene            8550..8795
                     /locus_tag="DVJ24_28390"
     CDS             8550..8795
                     /locus_tag="DVJ24_28390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146442.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WCN72472.1"
                     /translation="MTHLKLTPAEEKRLADAFVAQALAMGLKGNKTLPKAVKQQVRERV
                     LRAIQDEREARRAQEMRREKYEATETTFTWQPQRRR"
                     /name="hypothetical protein"
     gene            9069..9440
                     /gene="tolA"
                     /locus_tag="DVJ24_28395"
     CDS             9069..9440
                     /gene="tolA"
                     /locus_tag="DVJ24_28395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001237044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell envelope integrity protein TolA"
                     /protein_id="WCN72473.1"
                     /translation="MRLIPFILLALCSPLLLTACKHSTTQPPKIYTLDKSSKISSYAAA
                     IKTAVEMQMFEPEAYAGKMCTVRISIQRDGTLNSAIAEGGDPKLCKAAISAVTHAKIPP
                     APDENTWQIFKNAPLDFRP"
                     /name="tolA"
     gene            9437..9643
                     /locus_tag="DVJ24_28400"
                     /pseudo=""
     CDS             9437..9643
                     /locus_tag="DVJ24_28400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002193751.1"
                     /note="incomplete; partial on complete genome; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="TonB family protein"
                     /name="TonB family protein"
     BGC             1538..10060
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          5356..5934
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="98.282"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(1862..2589)
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="93.416"
                     /coverage="100.0"
                     /evalue="1.34e-140"
ORIGIN
        1 cacgcgctaa tgctggaggc aatcaccgaa tacatcgacc gggaagagaa gcgcagccag
       61 tacctgcggg acggacaggc cgcatggcag cactatcagg aaacgggtct gcaccttact
      121 gcggaagaag cggaagcctg gataagtacc tggggaactg agaacgagca ggatgctccg
      181 ccatgccaca ggtaacgatt tccgcgctgg cacagcgcga tttacaacgc cttcaggact
      241 ttctcaaaac caaaaatcgg ctggcagcca gaaaaggagg tgaggtgatc gtccgggcta
      301 tccagcaact gaaaacattg ccagacattg gccgcccggt gccgtttctg ccgctggaat
      361 ataaggaact ggtgatcggg tttggcgaca gtggctatgt gatgctctac cgccacgacc
      421 gggaaatgga ccagattgtg atcgtcaccg tcaggcatca gaaagaatcc gggtatccgg
      481 gggcagacag cctctaataa ccgatgacgg gggcgcaatt cattgcgtgg ccgtcgccgg
      541 tttgacaagc gcagcgcgtc agaaaaccac atcctgaacg gaaaaacggg taaaattcag
      601 cgatacattt accgtgagaa attacacacc tttcacaccc gataaaatca ggggtataca
      661 gtggcgaaaa cattgctcaa cctttcacag gcagcacaag ccgcgggcat taccagaaga
      721 acgctataca atcatgtaaa acagggaaag gttaccgtgt cacgtgacgg gaaaaacaac
      781 cctgtcgtgg atgtgtcaga actgatccgt gtatacggaa atgtgaatat ccctgagaaa
      841 caaattcccg gcatttcaca ccgtgaaaat acacaaaaaa atttcccaca ggaacagctt
      901 ctggcaatgc aaaaggaact ggccgatctc cggcaggctg tcaccctgat gctggaagat
      961 aaaacatccc gggaagaaga acgccgccag cacgatgatg agcgccggaa actccaggcc
     1021 gaagtggaca gattgacaac agaactgaca cagaagaaaa aacgcttctg gtccggctgg
     1081 tttagctgag aacttaccga agggaatgga gaacatgacg aagcaggaaa aaactgccct
     1141 caatatggct aaattcatta aggatcagtc gctgctgttg ctggaaaagc tgaacgagct
     1201 ggacatggat accccggccg acatgtgcga acggcttcac gaggatgcgg aaacactctg
     1261 gcaggtgatg cgggataagc tcggggaaga ataacagcac cggccatgcc ggtgctggcg
     1321 ttattttttg ccgaacggcc accaccggcg ggcgggtttg tcctccggca gttcaggcac
     1381 cggcacgtta aaatagcggc tgttatattc ccgcatcagc tccgctttca gcttctcgtt
     1441 caccgcgctt tccccgtgcc gctcgctgac cacctcaatc atcgcgttaa tctgctccgg
     1501 tgagcacttc ccggcatcaa ccacctgcac accgttctcg atggcgaacc gctccacctt
     1561 tcgatagagg taatcacaca gcttcattcc tgtgggtttg tcccgttccc attgcggatt
     1621 ttcaccggtg aaaaagtacg tggctttttc gtcgctgttg agccgctcgt catacatccc
     1681 gatggatttc atcatcgcca gatgctgggc ccggtcgaca aaacagaaaa catacgcccc
     1741 ggtctgccag gcgagcacca ccatgtcttc cagatgctcg ctggttggca taatgcagcg
     1801 ctcgccgtct ttgtcttcca cgtcctcaat aaataccatg tacagcgcca taatccctca
     1861 ctccgttgtc ataaatttaa agcacgcgaa cagcctctcc cggtccagct ccaccgtttt
     1921 gcgggcctcg ccggtctgtg gattcacgat ttcatccacc gccagaatcg cccgctgtac
     1981 ccggacaagc gtcggccggt cagggcagat gtaccagatt tcatcgatgc cgttcgcccg
     2041 gcggttgaac agatacccgg acaccacttc ctgataccgc ctgcggctct tgacggtgcg
     2101 ctctacctca aatgccaccg ttctgccgtc cagctccgcc agcgcgtccg gcactttcat
     2161 ccctttcagg gccatacggt gcaggtaccg ccagccggtg gccccccggc cctccatgga
     2221 gaggcgcagg gactgcacgg ccagccggtg cggcagctgc gccgccgaca cccttgacgg
     2281 ctgaaacgga ataacgtccg tcagcggctc gtcctcgtcg aacgagaacg ccaccccgtg
     2341 cggcgtcagc ccccacacgc tgacctgacg gccgtcaacc gggtatttcg cccggaccag
     2401 cagccctttc gccaccagac tgtccaggaa gcggtaaacc ggctgtaccg ccgcaatccc
     2461 cagccgtcgc gcaaccagct ccgccgtgga acacagctct tcccgcagcc agcgcagggt
     2521 cagccgtgtt ttctccgcgt tccgcgcctg ccgcttcgcg tggctgacgt tgtactgctc
     2581 cagtgtcatc agtaaagccc cgcaaaatca tcatccgctt ttggtccgcc gccgtcggcc
     2641 ggaggcaggt actccgccag cgggtccgtt ttcgccagca ccgggaaggt tttcagcgaa
     2701 atttcccggc gctcaacccg cagcgggctg ctgaacgcca gccgcgccac gcccagcccg
     2761 gtcatcaccg cgaacccgtc aggcaggtgt tgcagggtgt tcacgtcaaa cagcggccgc
     2821 gcctccttct ggatgaagct gtcgccgctg atgtgctcca cgttccccgc ctcccggctg
     2881 gcccggcggc gctccacgtc cacccggatc tccccggtct ggcccgccgc ccactgcgcg
     2941 gactcctggc tggccgcgcg atagaaccag cggatcggcg tgttatccag taccgtggtt
     3001 ttcacaaaat cagcgggcag atcctgcccg cactgaccga agtcgcccag cgactggtgc
     3061 gcgagcagca ggttgcagtc ccggctgcgc agcgtcccca gcgcgttcag cacgtacttc
     3121 gacagcagat atttaatctc atcgagcatg atgctcgcgt gcggccacct ccggaactca
     3181 tcccgcgcaa tgatgatttg cgcgcagcgg gcaaacagca tcttctgcac ccggatcacc
     3241 gcctcatcgt ccatcgagcc gatgacgtac aggcagccgc cgccgttgat tatccccgcc
     3301 acatcgatac cgctgtccgt ctgcaggacg ctcaggtcgg ccacgttctc cagcttggtg
     3361 atcagcccct tcacgtcctt tttcagggcc tccggcaacg cgtacgccgc cgccagcacc
     3421 tgctgaatgt ttgccccctg cgggaactgc tccgcaatca gcttcgccgc tttctgctcg
     3481 ctgatgcggt agtggtccgc cacgtcgccg gtctcactca ggttaaaccc ggcaaccagc
     3541 agattcttca gggcgtactg gtcgagatcg cggaacagat tcagctgcgc cggtttcccc
     3601 ggccgcagat ccagcagggt gaagtccggg cagtgcgccc ggaagacgtg cggcgcccac
     3661 gcgtcccctt tggggtcgaa gtacaccaca gcgtccccga aatcgcgtac gcagcgaatg
     3721 agcgcgttgg tggccatcgc gctcttgccg ctcccgggca ggccgaggat ctgaatattg
     3781 gtcttgcgcc aggtatcacg agggaccagc accggctggc cctgctcatc cttacccaga
     3841 aacaccgcct gctgtttccg ggcctgctcc gtggaaaaat cggccagcgc gttaaccggt
     3901 accggctccc cgaaatgcag gtggcggacg tctgtcattt ctccggtccg ctggctgctg
     3961 cgccggctct cctgattcag tttcgcgttc accgcctcgt cagcggccgc aaaatgacca
     4021 tcaagcagca ggaacgccag cagccgcgcc agaaggacgc cggcgacaag ccctccggca
     4081 caccaggcta tcccgaacag gttagccggc tgcagcaggt aataatctgc gttcgcatag
     4141 aggtccgggc gcaggacggt ttctccccag ctctcgataa acacggcgac aaccagcccc
     4201 cccagaaggg ccagaccggc agcgccggtc agccagtacg cgtagttcca gacatgtcgc
     4261 cgtgccctga ccatccgccc gggtgaatcc agcgaggcca gcaccgaaaa tggcacagtc
     4321 cggttattat cgcgcttata gcgatcggca tactcccgcc gcgccttatg gctcagcccc
     4381 acaaaacgca ttcggccggc ccagagttca gccagaccga aaaacaggcc gataaccaga
     4441 aaaaaaccgg ccagactgta atactcccgg tacagccagc tgacccacgg gtaaatctgc
     4501 cgggccagct ccgggatatg ccactgccag gcaagcgaat ccgtattaaa catgcaatct
     4561 ctctccttca gacgacgggt ttaccggcgt gatgcgcagc ccccgctgca caagccgcgg
     4621 acatgcccca aggcatggcg gcggcggtca cgtccgtggt gattgcgttc agctttcacc
     4681 gcggaggcca gcctctttcc gccccatgcg gaaaaggcgc agccccggag gaacaacgag
     4741 cacgccccag cgtgtgagag gaaaaggcgg caccccagtg cggtcttttc cggtgttccg
     4801 gcccccgtca gagttcgcca tagcgagcgg ctgaccaccc gcaaaatcag gagcagcttt
     4861 gctgcttcgt caggtgcgtc cagcaccgtg gatttttgtg ggtggtcagg cgtgagcctg
     4921 acgggggccg ggtgaatttc tggcgtggcc ggcgtccagc cggacagagc cagaaagagg
     4981 ggaaaagacc gtgcgtcggt ggcgtccagc cagcgtaagc aaggtctttt cccctgaagt
     5041 cagccacgcc ccagcgggga tgacttgcat ttctccgcaa ggagaaaaaa gcaacagaga
     5101 taggttaacg taaaatgttc agcgaaaaac cgacatggtt cacctatcct gataattgat
     5161 cgtcagggaa tagaaagact taatcagggg acaatatccc acatcagcgc gtccggtgac
     5221 cgtcttgcag gtgccgggga aattgcgcct cctcgctcac tcggtcgcta cgctccgggc
     5281 gtgagactgc ggcgggcgct gcggacacat acaaagttac ccacagattc cgtggataag
     5341 caggggacta acatgtgagg caaaacggca gggccgcgcc ggtggcgttt ttccataggc
     5401 tccgccctcc tgccagagtt cacataaaca gacgcttttt cggtgcatct gtgggagccg
     5461 tgaggctcaa ccatgaatct gacagtacgg gcgaaacccg acaggactta aagatcccca
     5521 ccgtttccgg taggtcgctc cctcttgcgc tctcctgttc cgaccctgcc gtttaccgga
     5581 tacctgtccg ccgttctccc ttgcgggaag tgtggcgctt tctcatagct cacacactgg
     5641 tatctcggct cggtgtaggt cgttcgctcc aagctgggct gtaagcaaga actccccgtt
     5701 cagcccgact gctgcgcctt atccggtaac tgttcacttg agtccaaccc gggaaagcac
     5761 gcaaaacgcc actggcagca gccattggta actgggagtt cgcagaggat ttgtttagct
     5821 aaacacgcgg ttgctcttga agtgtgcgcc aaagtccggc tacactggaa ggacagattt
     5881 ggttgctgtg ctctgcgaaa gccagttacc acggttaagc agttccccaa ctgacttaac
     5941 cttcgatcaa accacctccc caggtggttt tttcgtttac agggcaaaag attacgcgca
     6001 gaaaaaaagg atctcaagaa gatcctttga tcttttctac tgaaccgcga tccccgtcag
     6061 ttcagaggag gacgatggtg ccaccgttcc gccctgaaca tcccggatat aatttgcctg
     6121 acatgcggcc agaagaaagc cagcaacaat caatataaaa agaaaaatag tctttacctt
     6181 tttcatatac tttccctgta tttaaagact ccggcattca tccctgaaca ccggaagtca
     6241 gtatttcaaa tcatccttga taattttttg ttaccagtta ccgtcccgat aatcaaaagc
     6301 tatataacaa ttatccacat caggttttat ttgattttta aaaaatggct gtagtaaagg
     6361 aacccattct ttcttcaaat caaactcacc attattaata ttatccttta aaggcattcc
     6421 caagctttca atgacagaac catcgtcacc aaagtcttta gaatactctt cccctttaaa
     6481 ctcttcagtt ttcttatcaa accatgtcaa acgtaattta agccccatat ttacctctca
     6541 aagatatttt ttaatgttcc gttttggatc tggcccttta acctgcttac ccgttttggg
     6601 atcaaatgcg cctaggtgtt cgccatcact ggcacgatac ccttcaagct caccgtgctg
     6661 ggaatcccat tcataaattt tacgtttttt atcgccatac catcgggccc gcttaccacc
     6721 accaccttgt ttaggtgttt taggatcacc tcgctttaac tctccaagtc cctttatgtc
     6781 ttctgtttta ggtactggat gataatcatg gccgtagtct ttagtcccct tgcgaggctt
     6841 gttcttttcc tcatttaact tattttctgc atccttcgct tttttctcct tttgtttccg
     6901 gctctccatc gccccggtaa gtgcagcctt atctctggat aaggattcat tcattgcgtt
     6961 taaagatgcc tgagccgctt ttaatttctc attctgattc tgaatatcct tatcaagata
     7021 gcgaacctga tcctgccacc cggagccata ttcatgaggc gggttataag tcacaaaatc
     7081 atctttattt gcctctgcct cttttacctt tttatcggct tcctgaacag cagcccttgc
     7141 accggggagc gccttctctg tcgatgcaat gcggctgttt aaggtcgcaa tatttttatc
     7201 ttcggcatcc agctcagctt tcgctttatc atagtctctt ttcagcccct cttccggatg
     7261 agcggcgtcc catgcctgct ggcgacgctt ttcttcctcc tgacgctgtt ttacctgtgc
     7321 cggggtaaga acatctgtca ccgacacata aaccggcttc tgtccggtct ctttcgggaa
     7381 acgaataacg gcctcacggg agttaccacc ggctgtaaaa ccagccggac gtgaatcacc
     7441 tttttcagca acaatgcctt ttggcggggc tttcgctgtc ggaacacctt tcggtacgct
     7501 cacctgcaga gacgggagac ccggaatcga cacactgaat acccccggac gttttgtcgg
     7561 tttcgcatcc accacaggga cactcattgg ccgacctgcg acaaccgcaa tatgctgccg
     7621 ctcatccttc accacatcca caacccgttg tctgacacga accgtcgcct ggtccagtgg
     7681 taaagtactt gccggagtct ccgtcaccgc atcggccggt aatgacgtca taatttttga
     7741 catcattttc ggatcatctt ttgcaatctc agaaggcagc acaccgtaga tcgcaatccc
     7801 ccacagacca aacttaaacg gccccttcag ggcagccagc acatcagcaa cggcggccga
     7861 caacgcatcg ccggaaactg ataaagccag tccttcagcc cccggagtag ccagggcagg
     7921 cagaccgaag gccatcgcag tggccgaaga ctgtccgcca ccagagctac cgctatgatt
     7981 gccgctgtta ccaccattac caccgggttt actcccgccg ttaccaaact cccccggatt
     8041 atagttatga atatctccat tcggcgtatg cgtcgtaccc cagcccggcc cgctgtttgg
     8101 atccgtacca ccacctgatg aagggccacc tttaccagac gtaccgttca cattcccact
     8161 ggcctgacca ccattatgtc ccagacctga attacccgga cctcgaccgt ctccaccact
     8221 cataccgttt tcctctttga catttaaaac aataaattaa agccaacata ctgtacatat
     8281 acacagtata attattacct tactcctccc gttttcaggt gtcaatatat gagattagtt
     8341 ctcatcttca ggcacaaaaa agcgcccgga gccacctgta agcagatcgc gtcttttccc
     8401 gaaaatttct catggcaaca aattttatta tttaagacat tcatcacact tacatttcag
     8461 atggtataga cacatctgaa agctaactgg catgaggaga ggacctgcgg ttaaactgtt
     8521 cgggaaacct gagacgcccg gaggccacta tgacgcacct gaaactgact cccgctgaag
     8581 aaaagcgcct ggcggacgcc tttgtcgctc aggcactggc catgggcctg aaagggaaca
     8641 aaacgctgcc aaaggcggta aaacaacagg tgcgggaaag ggtgcttcgt gccattcagg
     8701 acgaacgtga agccaggcgg gcgcaggaaa tgcgtcggga gaaatacgag gctacggaaa
     8761 ccaccttcac ctggcagcca cagcgccgcc ggtaaggggt atttaccata acgtcgcatt
     8821 gcccgcaccg ctcagacggt ctgagggcgt ttccggcggc tacgggataa aacaggcaac
     8881 aaaccacccg gaaaaccgcc ggaaacgcgc ccggtaaatt gtaacccgct gcatgcctat
     8941 gcacgcaact gcatggcggg ccgtttggtg taaaaacgat acgataagcc gtgtttatgt
     9001 aaatgaacgt ggccgtaaag agtgacaaat atacatgtaa cattttttac tgacaggtca
     9061 tcaacccgat gcgtttaata ccctttatcc tgctggcatt gtgcagcccc ttactcctga
     9121 cggcctgtaa gcattccacc acccagccgc cgaaaattta tactctggat aagtcatcta
     9181 aaatcagtag ctacgctgcg gccatcaaga ccgctgttga aatgcagatg tttgaaccag
     9241 aggcctatgc gggaaaaatg tgcaccgtgc ggatatccat acaacgtgat ggcactctga
     9301 acagcgccat tgctgaagga ggagatccga aactctgtaa agcagcaata tcagccgtta
     9361 cccacgccaa aattccgccg gcaccggatg aaaatacctg gcaaatattc aaaaacgccc
     9421 ctctggattt cagaccatga aagcttttac tctgacagtg ctggcggcca tgttcctcac
     9481 tccggtacat gcgataccac taaaacccgt aaccacactg cagccaacct acccggtaca
     9541 ggccgcagca aaacgcatcg aaggtcaggt gaccgccacg tttgatattc tggacgatgg
     9601 acgagtggac aacgtgtcgc ttaccggctg tcaccttttt tttcgggaaa cgctgacggc
     9661 aatgaggcac tggctatatc ccgcagggca cccggcaatg cgacaggtta taaattttga
     9721 attcagtctg aaaaatgacg gcttacagga tccgcgacca gtcaccaccc aaaagctcaa
     9781 tgatgatggt tgccgccagt aacaggtcct ttaacccgca ggctgcaata gtcctggatg
     9841 atgagtgagc ctgtagcagc cctgattagt ggaagcgaag ctgaaaaatg ggcagcaaaa
     9901 gccgtatttc tggcaaatag cgccgccacg gattaaagta gtcatgtgta atacatatga
     9961 ctacaaaggg gcttttatgt catcagcaac atccatcagg ctcgatgaag aacttaagga
    10021 ccggctgaaa acgctggccg atgaccggca ccgctcagcg
//
