LOCUS       CP046889               10060 bp    DNA     circular BCT 06-FEB-2023
DEFINITION  Klebsiella pneumoniae strain WCHKP090276 plasmid p2_090276, complete
            sequence.
ACCESSION   CP046889
VERSION     CP046889.1
DBLINK      BioProject: PRJNA353728
            BioSample: SAMN13567230
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 10060)
  AUTHORS   Wei,L., Liu,Y., Liu,L., Feng,Y. and Zong,Z.
  TITLE     The complete genome of Klebsiella pneumoniae strain WCHKP090276
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10060)
  AUTHORS   Wei,L., Liu,Y., Liu,L., Feng,Y. and Zong,Z.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-DEC-2019) Center of Infectious Diseases, West China
            Hospital, Sichuan University, Guoxuexiang 37, Chengdu, Sichuan
            610041, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 12/16/2019 11:38:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 4.10
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 5,825
            CDSs (total)                      :: 5,703
            Genes (coding)                    :: 5,590
            CDSs (with protein)               :: 5,590
            Genes (RNA)                       :: 122
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 87
            ncRNAs                            :: 10
            Pseudo Genes (total)              :: 113
            CDSs (without protein)            :: 113
            Pseudo Genes (ambiguous residues) :: 0 of 113
            Pseudo Genes (frameshifted)       :: 41 of 113
            Pseudo Genes (incomplete)         :: 71 of 113
            Pseudo Genes (internal stop)      :: 20 of 113
            Pseudo Genes (multiple problems)  :: 18 of 113
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..10060
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="WCHKP090276"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="p2_090276"
                     /geo_loc_name="China: Chengdu, Sichuan"
                     /collection_date="2019-03"
     gene            join(9931..10060,1..185)
                     /locus_tag="GQR74_29020"
     CDS             join(9931..10060,1..185)
                     /locus_tag="GQR74_29020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001136729.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WCN56553.1"
                     /translation="MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKT
                     LPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDREMDQIVIVTVRHQKESGYPGADSL
                     "
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            349..777
                     /locus_tag="GQR74_29025"
     CDS             349..777
                     /locus_tag="GQR74_29025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WCN56554.1"
                     /translation="MAKTLLNLSQAAQAAGITRRTLYNHVKQGKVTVSRDGKNNPVVDV
                     SELIRVYGNVNIPEKQIPGISHRENTQKNFPQEQLLAMQKELADLRQAVTLMLEDKTSR
                     EEERRQHDDERRKLQAEVDRLTTELTQKKKRFWSGWFS"
                     /name="hypothetical protein"
     gene            803..982
                     /locus_tag="GQR74_29030"
     CDS             803..982
                     /locus_tag="GQR74_29030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WCN56555.1"
                     /translation="MTKQEKTALNMAKFIKDQSLLLLEKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(1009..1539)
                     /locus_tag="GQR74_29035"
     CDS             complement(1009..1539)
                     /locus_tag="GQR74_29035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WCN56556.1"
                     /translation="MALYMVFIEDVEDKDGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGENPQWERDKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIEVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(1546..2277)
                     /locus_tag="GQR74_29040"
     CDS             complement(1546..2277)
                     /locus_tag="GQR74_29040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WCN56557.1"
                     /translation="MTLEQYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRAKYPVDGRQVSVWGLTPHGVAFSFDEDEPLTDVIPFQP
                     SRVSAAQLPHRLAVQSLRLSMEGRGATGWRYLHRMALKGMKVPDALAELDGRTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRRANGIDEIWYICPDRPTLVRVQRAILAVDEIVNPQTGEA
                     RKTVELDRERLFACFKFMTTE"
                     /name="hypothetical protein"
     gene            complement(2277..4241)
                     /locus_tag="GQR74_29045"
     CDS             complement(2277..4241)
                     /locus_tag="GQR74_29045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WCN56558.1"
                     /translation="MFNTDSLAWQWHIPELARQIYPWVSWLYREYYSLAGFFLVIGLFF
                     GLAELWAGRMRFVGLSHKARREYADRYKRDNNRTVPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLV
                     AGVLLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSTEQARKQQAVFLGKDEQGQPVLVPRDTWRKTNIQILGLPGSGKSAMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLV
                     AGFNLSETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     KLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFRRWPHASIMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPADFV
                     KTTVLDNTPIRWFYRAASQESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARLAFSSPLRVERREISLKTFPVLAKTDPLAEY
                     LPPADGGGPKADDDFAGLY"
                     /name="TraM recognition domain-containing protein"
     gene            complement(5725..5874)
                     /locus_tag="GQR74_29050"
     CDS             complement(5725..5874)
                     /locus_tag="GQR74_29050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lysis protein"
                     /protein_id="WCN56559.1"
                     /translation="MKKVKTIFLFILIVAGFLLAACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="lysis protein"
     gene            complement(5959..6216)
                     /locus_tag="GQR74_29055"
     CDS             complement(5959..6216)
                     /locus_tag="GQR74_29055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="WCN56560.1"
                     /translation="MGLKLRLTWFDKKTEEFKGEEYSKDFGDDGSVIESLGMPLKDNIN
                     NGEFDLKKEWVPLLQPFFKNQIKPDVDNCYIAFDYRDGNW"
                     /name="cloacin"
     gene            complement(6226..7911)
                     /locus_tag="GQR74_29060"
     CDS             complement(6226..7911)
                     /locus_tag="GQR74_29060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="WCN56561.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IMTSLPADAVTETPASTLPLDQATVRVRQRVVDVVKDERQHIAVVAGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPTAKAPPKGIVAEKGDSRPAGFTAGGNSREAVIR
                     FPKETGQKPVYVSVTDVLTPAQVKQRQEEEKRRQQAWDAAHPEEGLKRDYDKAKAELDA
                     EDKNIATLNSRIASTEKALPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQASLNAMNESLSRDKAALTGAMESRKQKEKKAKDAENKLNE
                     EKNKPRKGTKDYGHDYHPVPKTEDIKGLGELKRGDPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="cloacin"
     gene            8238..8483
                     /locus_tag="GQR74_29065"
     CDS             8238..8483
                     /locus_tag="GQR74_29065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146442.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WCN56562.1"
                     /translation="MTHLKLTPAEEKRLADAFVAQALAMGLKGNKTLPKAVKQQVRERV
                     LRAIQDEREARRAQEMRREKYEATETTFTWQPQRRR"
                     /name="hypothetical protein"
     gene            8757..9128
                     /gene="tolA"
                     /locus_tag="GQR74_29070"
     CDS             8757..9128
                     /gene="tolA"
                     /locus_tag="GQR74_29070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001237044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell envelope integrity protein TolA"
                     /protein_id="WCN56563.1"
                     /translation="MRLIPFILLALCSPLLLTACKHSTTQPPKIYTLDKSSKISSYAAA
                     IKTAVEMQMFEPEAYAGKMCTVRISIQRDGTLNSAIAEGGDPKLCKAAISAVTHAKIPP
                     APDENTWQIFKNAPLDFRP"
                     /name="tolA"
     gene            9125..9331
                     /locus_tag="GQR74_29075"
                     /pseudo=""
     CDS             9125..9331
                     /locus_tag="GQR74_29075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002193751.1"
                     /note="incomplete; partial on complete genome; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="TonB family protein"
                     /name="TonB family protein"
     gene            9665..9943
                     /locus_tag="GQR74_29080"
     CDS             9665..9943
                     /locus_tag="GQR74_29080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019952150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribbon-helix-helix protein, CopG family"
                     /protein_id="WCN56564.1"
                     /translation="MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEK
                     RSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWGTENEQDAPPCHR"
                     /name="ribbon-helix-helix protein, CopG family"
     BGC             1226..10060
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          5044..5622
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="98.282"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(1550..2277)
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="93.416"
                     /coverage="100.0"
                     /evalue="1.34e-140"
ORIGIN
        1 aaacattgcc agacattggc cgcccggtgc cgtttctgcc gctggaatat aaggaactgg
       61 tgatcgggtt tggcgacagt ggctatgtga tgctctaccg ccacgaccgg gaaatggacc
      121 agattgtgat cgtcaccgtc aggcatcaga aagaatccgg gtatccgggg gcagacagcc
      181 tctaataacc gatgacgggg gcgcaattca ttgcgtggcc gtcgccggtt tgacaagcgc
      241 agcgcgtcag aaaaccacat cctgaacgga aaaacgggta aaattcagcg atacatttac
      301 cgtgagaaat tacacacctt tcacacccga taaaatcagg ggtatacagt ggcgaaaaca
      361 ttgctcaacc tttcacaggc agcacaagcc gcgggcatta ccagaagaac gctatacaat
      421 catgtaaaac agggaaaggt taccgtgtca cgtgacggga aaaacaaccc tgtcgtggat
      481 gtgtcagaac tgatccgtgt atacggaaat gtgaatatcc ctgagaaaca aattcccggc
      541 atttcacacc gtgaaaatac acaaaaaaat ttcccacagg aacagcttct ggcaatgcaa
      601 aaggaactgg ccgatctccg gcaggctgtc accctgatgc tggaagataa aacatcccgg
      661 gaagaagaac gccgccagca cgatgatgag cgccggaaac tccaggccga agtggacaga
      721 ttgacaacag aactgacaca gaagaaaaaa cgcttctggt ccggctggtt tagctgagaa
      781 cttaccgaag ggaatggaga acatgacgaa gcaggaaaaa actgccctca atatggctaa
      841 attcattaag gatcagtcgc tgctgttgct ggaaaagctg aacgagctgg acatggatac
      901 cccggccgac atgtgcgaac ggcttcacga ggatgcggaa acactctggc aggtgatgcg
      961 ggataagctc ggggaagaat aacagcaccg gccatgccgg tgctggcgtt attttttgcc
     1021 gaacggccac caccggcggg cgggtttgtc ctccggcagt tcaggcaccg gcacgttaaa
     1081 atagcggctg ttatattccc gcatcagctc cgctttcagc ttctcgttca ccgcgctttc
     1141 cccgtgccgc tcgctgacca cctcaatcat cgcgttaatc tgctccggtg agcacttccc
     1201 ggcatcaacc acctgcacac cgttctcgat ggcgaaccgc tccacctttc gatagaggta
     1261 atcacacagc ttcattcctg tgggtttgtc ccgttcccat tgcggatttt caccggtgaa
     1321 aaagtacgtg gctttttcgt cgctgttgag ccgctcgtca tacatcccga tggatttcat
     1381 catcgccaga tgctgggccc ggtcgacaaa acagaaaaca tacgccccgg tctgccaggc
     1441 gagcaccacc atgtcttcca gatgctcgct ggttggcata atgcagcgct cgccgtcttt
     1501 gtcttccacg tcctcaataa ataccatgta cagcgccata atccctcact ccgttgtcat
     1561 aaatttaaag cacgcgaaca gcctctcccg gtccagctcc accgttttgc gggcctcgcc
     1621 ggtctgtgga ttcacgattt catccaccgc cagaatcgcc cgctgtaccc ggacaagcgt
     1681 cggccggtca gggcagatgt accagatttc atcgatgccg ttcgcccggc ggttgaacag
     1741 atacccggac accacttcct gataccgcct gcggctcttg acggtgcgct ctacctcaaa
     1801 tgccaccgtt ctgccgtcca gctccgccag cgcgtccggc actttcatcc ctttcagggc
     1861 catacggtgc aggtaccgcc agccggtggc cccccggccc tccatggaga ggcgcaggga
     1921 ctgcacggcc agccggtgcg gcagctgcgc cgccgacacc cttgacggct gaaacggaat
     1981 aacgtccgtc agcggctcgt cctcgtcgaa cgagaacgcc accccgtgcg gcgtcagccc
     2041 ccacacgctg acctgacggc cgtcaaccgg gtatttcgcc cggaccagca gccctttcgc
     2101 caccagactg tccaggaagc ggtaaaccgg ctgtaccgcc gcaatcccca gccgtcgcgc
     2161 aaccagctcc gccgtggaac acagctcttc ccgcagccag cgcagggtca gccgtgtttt
     2221 ctccgcgttc cgcgcctgcc gcttcgcgtg gctgacgttg tactgctcca gtgtcatcag
     2281 taaagccccg caaaatcatc atccgctttt ggtccgccgc cgtcggccgg aggcaggtac
     2341 tccgccagcg ggtccgtttt cgccagcacc gggaaggttt tcagcgaaat ttcccggcgc
     2401 tcaacccgca gcgggctgct gaacgccagc cgcgccacgc ccagcccggt catcaccgcg
     2461 aacccgtcag gcaggtgttg cagggtgttc acgtcaaaca gcggccgcgc ctccttctgg
     2521 atgaagctgt cgccgctgat gtgctccacg ttccccgcct cccggctggc ccggcggcgc
     2581 tccacgtcca cccggatctc cccggtctgg cccgccgccc actgcgcgga ctcctggctg
     2641 gccgcgcgat agaaccagcg gatcggcgtg ttatccagta ccgtggtttt cacaaaatca
     2701 gcgggcagat cctgcccgca ctgaccgaag tcgcccagcg actggtgcgc gagcagcagg
     2761 ttgcagtccc ggctgcgcag cgtccccagc gcgttcagca cgtacttcga cagcagatat
     2821 ttaatctcat cgagcatgat gctcgcgtgc ggccacctcc ggaactcatc ccgcgcaatg
     2881 atgatttgcg cgcagcgggc aaacagcatc ttctgcaccc ggatcaccgc ctcatcgtcc
     2941 atcgagccga tgacgtacag gcagccgccg ccgttgatta tccccgccac atcgataccg
     3001 ctgtccgtct gcaggacgct caggtcggcc acgttctcca gcttggtgat cagccccttc
     3061 acgtcctttt tcagggcctc cggcaacgcg tacgccgccg ccagcacctg ctgaatgttt
     3121 gccccctgcg ggaactgctc cgcaatcagc ttcgccgctt tctgctcgct gatgcggtag
     3181 tggtccgcca cgtcgccggt ctcactcagg ttaaacccgg caaccagcag attcttcagg
     3241 gcgtactggt cgagatcgcg gaacagattc agctgcgccg gtttccccgg ccgcagatcc
     3301 agcagggtga agtccgggca gtgcgcccgg aagacgtgcg gcgcccacgc gtcccctttg
     3361 gggtcgaagt acaccacagc gtccccgaaa tcgcgtacgc agcgaatgag cgcgttggtg
     3421 gccatcgcgc tcttgccgct cccgggcagg ccgaggatct gaatattggt cttgcgccag
     3481 gtatcacgag ggaccagcac cggctggccc tgctcatcct tacccagaaa caccgcctgc
     3541 tgtttccggg cctgctccgt ggaaaaatcg gccagcgcgt taaccggtac cggctccccg
     3601 aaatgcaggt ggcggacgtc tgtcatttct ccggtccgct ggctgctgcg ccggctctcc
     3661 tgattcagtt tcgcgttcac cgcctcgtca gcggccgcaa aatgaccatc aagcagcagg
     3721 aacgccagca gccgcgccag aaggacgccg gcgacaagcc ctccggcaca ccaggctatc
     3781 ccgaacaggt tagccggctg cagcaggtaa taatctgcgt tcgcatagag gtccgggcgc
     3841 aggacggttt ctccccagct ctcgataaac acggcgacaa ccagcccccc cagaagggcc
     3901 agaccggcag cgccggtcag ccagtacgcg tagttccaga catgtcgccg tgccctgacc
     3961 atccgcccgg gtgaatccag cgaggccagc accgaaaatg gcacagtccg gttattatcg
     4021 cgcttatagc gatcggcata ctcccgccgc gccttatggc tcagccccac aaaacgcatt
     4081 cggccggccc agagttcagc cagaccgaaa aacaggccga taaccagaaa aaaaccggcc
     4141 agactgtaat actcccggta cagccagctg acccacgggt aaatctgccg ggccagctcc
     4201 gggatatgcc actgccaggc aagcgaatcc gtattaaaca tgcaatctct ctccttcaga
     4261 cgacgggttt accggcgtga tgcgcagccc ccgctgcaca agccgcggac atgccccaag
     4321 gcatggcggc ggcggtcacg tccgtggtga ttgcgttcag ctttcaccgc ggaggccagc
     4381 ctctttccgc cccatgcgga aaaggcgcag ccccggagga acaacgagca cgccccagcg
     4441 tgtgagagga aaaggcggca ccccagtgcg gtcttttccg gtgttccggc ccccgtcaga
     4501 gttcgccata gcgagcggct gaccacccgc aaaatcagga gcagctttgc tgcttcgtca
     4561 ggtgcgtcca gcaccgtgga tttttgtggg tggtcaggcg tgagcctgac gggggccggg
     4621 tgaatttctg gcgtggccgg cgtccagccg gacagagcca gaaagagggg aaaagaccgt
     4681 gcgtcggtgg cgtccagcca gcgtaagcaa ggtcttttcc cctgaagtca gccacgcccc
     4741 agcggggatg acttgcattt ctccgcaagg agaaaaaagc aacagagata ggttaacgta
     4801 aaatgttcag cgaaaaaccg acatggttca cctatcctga taattgatcg tcagggaata
     4861 gaaagactta atcaggggac aatatcccac atcagcgcgt ccggtgaccg tcttgcaggt
     4921 gccggggaaa ttgcgcctcc tcgctcactc ggtcgctacg ctccgggcgt gagactgcgg
     4981 cgggcgctgc ggacacatac aaagttaccc acagattccg tggataagca ggggactaac
     5041 atgtgaggca aaacggcagg gccgcgccgg tggcgttttt ccataggctc cgccctcctg
     5101 ccagagttca cataaacaga cgctttttcg gtgcatctgt gggagccgtg aggctcaacc
     5161 atgaatctga cagtacgggc gaaacccgac aggacttaaa gatccccacc gtttccggta
     5221 ggtcgctccc tcttgcgctc tcctgttccg accctgccgt ttaccggata cctgtccgcc
     5281 gttctccctt gcgggaagtg tggcgctttc tcatagctca cacactggta tctcggctcg
     5341 gtgtaggtcg ttcgctccaa gctgggctgt aagcaagaac tccccgttca gcccgactgc
     5401 tgcgccttat ccggtaactg ttcacttgag tccaacccgg gaaagcacgc aaaacgccac
     5461 tggcagcagc cattggtaac tgggagttcg cagaggattt gtttagctaa acacgcggtt
     5521 gctcttgaag tgtgcgccaa agtccggcta cactggaagg acagatttgg ttgctgtgct
     5581 ctgcgaaagc cagttaccac ggttaagcag ttccccaact gacttaacct tcgatcaaac
     5641 cacctcccca ggtggttttt tcgtttacag ggcaaaagat tacgcgcaga aaaaaaggat
     5701 ctcaagaaga tcctttgatc ttttctactg aaccgcgatc cccgtcagtt cagaggagga
     5761 cgatggtgcc accgttccgc cctgaacatc ccggatataa tttgcctgac atgcggccag
     5821 aagaaagcca gcaacaatca atataaaaag aaaaatagtc tttacctttt tcatatactt
     5881 tccctgtatt taaagactcc ggcattcatc cctgaacacc ggaagtcagt atttcaaatc
     5941 atccttgata attttttgtt accagttacc gtcccgataa tcaaaagcta tataacaatt
     6001 atccacatca ggttttattt gatttttaaa aaatggctgt agtaaaggaa cccattcttt
     6061 cttcaaatca aactcaccat tattaatatt atcctttaaa ggcattccca agctttcaat
     6121 gacagaacca tcgtcaccaa agtctttaga atactcttcc cctttaaact cttcagtttt
     6181 cttatcaaac catgtcaaac gtaatttaag ccccatattt acctctcaaa gatatttttt
     6241 aatgttccgt tttggatctg gccctttaac ctgcttaccc gttttgggat caaatgcgcc
     6301 taggtgttcg ccatcactgg cacgataccc ttcaagctca ccgtgctggg aatcccattc
     6361 ataaatttta cgttttttat cgccatacca tcgggcccgc ttaccaccac caccttgttt
     6421 aggtgtttta ggatcacctc gctttaactc tccaagtccc tttatgtctt ctgttttagg
     6481 tactggatga taatcatggc cgtagtcttt agtccccttg cgaggcttgt tcttttcctc
     6541 atttaactta ttttctgcat ccttcgcttt tttctccttt tgtttccggc tctccatcgc
     6601 cccggtaagt gcagccttat ctctggataa ggattcattc attgcgttta aagatgcctg
     6661 agccgctttt aatttctcat tctgattctg aatatcctta tcaagatagc gaacctgatc
     6721 ctgccacccg gagccatatt catgaggcgg gttataagtc acaaaatcat ctttatttgc
     6781 ctctgcctct tttacctttt tatcggcttc ctgaacagca gcccttgcac cggggagcgc
     6841 cttctctgtc gatgcaatgc ggctgtttaa ggtcgcaata tttttatctt cggcatccag
     6901 ctcagctttc gctttatcat agtctctttt cagcccctct tccggatgag cggcgtccca
     6961 tgcctgctgg cgacgctttt cttcctcctg acgctgtttt acctgtgccg gggtaagaac
     7021 atctgtcacc gacacataaa ccggcttctg tccggtctct ttcgggaaac gaataacggc
     7081 ctcacgggag ttaccaccgg ctgtaaaacc agccggacgt gaatcacctt tttcagcaac
     7141 aatgcctttt ggcggggctt tcgctgtcgg aacacctttc ggtacgctca cctgcagaga
     7201 cgggagaccc ggaatcgaca cactgaatac ccccggacgt tttgtcggtt tcgcatccac
     7261 cacagggaca ctcattggcc gacctgcgac aaccgcaata tgctgccgct catccttcac
     7321 cacatccaca acccgttgtc tgacacgaac cgtcgcctgg tccagtggta aagtacttgc
     7381 cggagtctcc gtcaccgcat cggccggtaa tgacgtcata atttttgaca tcattttcgg
     7441 atcatctttt gcaatctcag aaggcagcac accgtagatc gcaatccccc acagaccaaa
     7501 cttaaacggc cccttcaggg cagccagcac atcagcaacg gcggccgaca acgcatcgcc
     7561 ggaaactgat aaagccagtc cttcagcccc cggagtagcc agggcaggca gaccgaaggc
     7621 catcgcagtg gccgaagact gtccgccacc agagctaccg ctatgattgc cgctgttacc
     7681 accattacca ccgggtttac tcccgccgtt accaaactcc cccggattat agttatgaat
     7741 atctccattc ggcgtatgcg tcgtacccca gcccggcccg ctgtttggat ccgtaccacc
     7801 acctgatgaa gggccacctt taccagacgt accgttcaca ttcccactgg cctgaccacc
     7861 attatgtccc agacctgaat tacccggacc tcgaccgtct ccaccactca taccgttttc
     7921 ctctttgaca tttaaaacaa taaattaaag ccaacatact gtacatatac acagtataat
     7981 tattacctta ctcctcccgt tttcaggtgt caatatatga gattagttct catcttcagg
     8041 cacaaaaaag cgcccggagc cacctgtaag cagatcgcgt cttttcccga aaatttctca
     8101 tggcaacaaa ttttattatt taagacattc atcacactta catttcagat ggtatagaca
     8161 catctgaaag ctaactggca tgaggagagg acctgcggtt aaactgttcg ggaaacctga
     8221 gacgcccgga ggccactatg acgcacctga aactgactcc cgctgaagaa aagcgcctgg
     8281 cggacgcctt tgtcgctcag gcactggcca tgggcctgaa agggaacaaa acgctgccaa
     8341 aggcggtaaa acaacaggtg cgggaaaggg tgcttcgtgc cattcaggac gaacgtgaag
     8401 ccaggcgggc gcaggaaatg cgtcgggaga aatacgaggc tacggaaacc accttcacct
     8461 ggcagccaca gcgccgccgg taaggggtat ttaccataac gtcgcattgc ccgcaccgct
     8521 cagacggtct gagggcgttt ccggcggcta cgggataaaa caggcaacaa accacccgga
     8581 aaaccgccgg aaacgcgccc ggtaaattgt aacccgctgc atgcctatgc acgcaactgc
     8641 atggcgggcc gtttggtgta aaaacgatac gataagccgt gtttatgtaa atgaacgtgg
     8701 ccgtaaagag tgacaaatat acatgtaaca ttttttactg acaggtcatc aacccgatgc
     8761 gtttaatacc ctttatcctg ctggcattgt gcagcccctt actcctgacg gcctgtaagc
     8821 attccaccac ccagccgccg aaaatttata ctctggataa gtcatctaaa atcagtagct
     8881 acgctgcggc catcaagacc gctgttgaaa tgcagatgtt tgaaccagag gcctatgcgg
     8941 gaaaaatgtg caccgtgcgg atatccatac aacgtgatgg cactctgaac agcgccattg
     9001 ctgaaggagg agatccgaaa ctctgtaaag cagcaatatc agccgttacc cacgccaaaa
     9061 ttccgccggc accggatgaa aatacctggc aaatattcaa aaacgcccct ctggatttca
     9121 gaccatgaaa gcttttactc tgacagtgct ggcggccatg ttcctcactc cggtacatgc
     9181 gataccacta aaacccgtaa ccacactgca gccaacctac ccggtacagg ccgcagcaaa
     9241 acgcatcgaa ggtcaggtga ccgccacgtt tgatattctg gacgatggac gagtggacaa
     9301 cgtgtcgctt accggctgtc accttttttt tcgggaaacg ctgacggcaa tgaggcactg
     9361 gctatatccc gcagggcacc cggcaatgcg acaggttata aattttgaat tcagtctgaa
     9421 aaatgacggc ttacaggatc cgcgaccagt caccacccaa aagctcaatg atgatggttg
     9481 ccgccagtaa caggtccttt aacccgcagg ctgcaatagt cctggatgat gagtgagcct
     9541 gtagcagccc tgattagtgg aagcgaagct gaaaaatggg cagcaaaagc cgtatttctg
     9601 gcaaatagcg ccgccacgga ttaaagtagt catgtgtaat acatatgact acaaaggggc
     9661 ttttatgtca tcagcaacat ccatcaggct cgatgaagaa cttaaggacc ggctgaaaac
     9721 gctggccgat gaccggcacc gctcagcgca cgcgctaatg ctggaggcaa tcaccgaata
     9781 catcgaccgg gaagagaagc gcagccagta cctgcgggac ggacaggccg catggcagca
     9841 ctatcaggaa acgggtctgc accttactgc ggaagaagcg gaagcctgga taagtacctg
     9901 gggaactgag aacgagcagg atgctccgcc atgccacagg taacgatttc cgcgctggca
     9961 cagcgcgatt tacaacgcct tcaggacttt ctcaaaacca aaaatcggct ggcagccaga
    10021 aaaggaggtg aggtgatcgt ccgggctatc cagcaactga
//
