LOCUS       CP043606               10060 bp    DNA     circular BCT 21-MAR-2022
DEFINITION  Klebsiella pneumoniae strain WCHKP115038 plasmid p1_115038, complete
            sequence.
ACCESSION   CP043606
VERSION     CP043606.1
DBLINK      BioProject: PRJNA353728
            BioSample: SAMN09688152
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 10060)
  AUTHORS   Hu,Y., Feng,Y. and Zong,Z.
  TITLE     The complete genome of Klebsiella pneumoniae strain WCHKP115038
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10060)
  AUTHORS   Hu,Y., Feng,Y. and Zong,Z.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-SEP-2019) Center of Infectious Diseases, West China
            Hospital, Sichuan University, Guoxuexiang 37, Chengdu, Sichuan
            610041, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.7
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 09/04/2019 17:28:40
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Annotation Software revision      :: 4.9
            Genes (total)                     :: 5,932
            CDSs (total)                      :: 5,810
            Genes (coding)                    :: 5,643
            CDSs (with protein)               :: 5,643
            Genes (RNA)                       :: 122
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 87
            ncRNAs                            :: 10
            Pseudo Genes (total)              :: 167
            CDSs (without protein)            :: 167
            Pseudo Genes (ambiguous residues) :: 0 of 167
            Pseudo Genes (frameshifted)       :: 51 of 167
            Pseudo Genes (incomplete)         :: 113 of 167
            Pseudo Genes (internal stop)      :: 30 of 167
            Pseudo Genes (multiple problems)  :: 23 of 167
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..10060
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="WCHKP115038"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="p1_115038"
                     /geo_loc_name="China: Chengdu, Sichuan"
                     /collection_date="2018"
     gene            complement(25..339)
                     /locus_tag="DVJ44_29520"
     CDS             complement(25..339)
                     /locus_tag="DVJ44_29520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001136729.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="UNM54896.1"
                     /translation="MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKT
                     LPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDREMDQIVIVTVRHQKESGYPGADSL
                     "
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(327..605)
                     /locus_tag="DVJ44_29525"
     CDS             complement(327..605)
                     /locus_tag="DVJ44_29525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019952150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribbon-helix-helix protein, CopG family"
                     /protein_id="UNM54897.1"
                     /translation="MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEK
                     RSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWGTENEQDAPPCHR"
                     /name="ribbon-helix-helix protein, CopG family"
     gene            complement(780..1145)
                     /locus_tag="DVJ44_29530"
     CDS             complement(780..1145)
                     /locus_tag="DVJ44_29530"
                     /inference="COORDINATES: protein motif:HMM:TIGR01352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TonB family protein"
                     /protein_id="UNM54898.1"
                     /translation="MKAFTLTVLAAMFLTPVHAIPLKPVTTLQPTYPVQAAAKRIEGQV
                     TATFDILDDGRVDNVSLTGCHLFFRETLTAMRHWLYPAGHPAMRQVINFEFSLKNDGLQ
                     DPRPVTTQKLNDDGCRQ"
                     /name="TonB family protein"
     gene            complement(1142..1513)
                     /gene="tolA"
                     /locus_tag="DVJ44_29535"
     CDS             complement(1142..1513)
                     /gene="tolA"
                     /locus_tag="DVJ44_29535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001237044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell envelope integrity protein TolA"
                     /protein_id="UNM54899.1"
                     /translation="MRLIPFILLALCSPLLLTACKHSTTQPPKIYTLDKSSKISSYAAA
                     IKTAVEMQMFEPEAYAGKMCTVRISIQRDGTLNSAIAEGGDPKLCKAAISAVTHAKIPP
                     APDENTWQIFKNAPLDFRP"
                     /name="tolA"
     gene            complement(1787..2032)
                     /locus_tag="DVJ44_29540"
     CDS             complement(1787..2032)
                     /locus_tag="DVJ44_29540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146442.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UNM54900.1"
                     /translation="MTHLKLTPAEEKRLADAFVAQALAMGLKGNKTLPKAVKQQVRERV
                     LRAIQDEREARRAQEMRREKYEATETTFTWQPQRRR"
                     /name="hypothetical protein"
     gene            2359..4044
                     /locus_tag="DVJ44_29545"
     CDS             2359..4044
                     /locus_tag="DVJ44_29545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="UNM54901.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IMTSLPADAVTETPASTLPLDQATVRVRQRVVDVVKDERQHIAVVAGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPTAKAPPKGIVAEKGDSRPAGFTAGGNSREAVIR
                     FPKETGQKPVYVSVTDVLTPAQVKQRQEEEKRRQQAWDAAHPEEGLKRDYDKAKAELDA
                     EDKNIATLNSRIASTEKALPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQASLNAMNESLSRDKAALTGAMESRKQKEKKAKDAENKLNE
                     EKNKPRKGTKDYGHDYHPVPKTEDIKGLGELKRGDPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="cloacin"
     gene            4054..4311
                     /locus_tag="DVJ44_29550"
     CDS             4054..4311
                     /locus_tag="DVJ44_29550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="UNM54902.1"
                     /translation="MGLKLRLTWFDKKTEEFKGEEYSKDFGDDGSVIESLGMPLKDNIN
                     NGEFDLKKEWVPLLQPFFKNQIKPDVDNCYIAFDYRDGNW"
                     /name="cloacin"
     gene            4396..4545
                     /locus_tag="DVJ44_29555"
     CDS             4396..4545
                     /locus_tag="DVJ44_29555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lysis protein"
                     /protein_id="UNM54903.1"
                     /translation="MKKVKTIFLFILIVAGFLLAACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="lysis protein"
     gene            5696..6001
                     /locus_tag="DVJ44_29560"
     CDS             5696..6001
                     /locus_tag="DVJ44_29560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UNM54904.1"
                     /translation="MLDAPDEAAKLLLILRVVSRSLWRTLTGAGTPEKTALGCRLFLSH
                     AGACSLFLRGCAFSAWGGKRLASAVKAERNHHGRDRRRHALGHVRGLCSGGCASRR"
                     /name="hypothetical protein"
     gene            6029..7993
                     /locus_tag="DVJ44_29565"
     CDS             6029..7993
                     /locus_tag="DVJ44_29565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="UNM54905.1"
                     /translation="MFNTDSLAWQWHIPELARQIYPWVSWLYREYYSLAGFFLVIGLFF
                     GLAELWAGRMRFVGLSHKARREYADRYKRDNNRTVPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLV
                     AGVLLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSTEQARKQQAVFLGKDEQGQPVLVPRDTWRKTNIQILGLPGSGKSAMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLV
                     AGFNLSETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     KLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFRRWPHASIMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPADFV
                     KTTVLDNTPIRWFYRAASQESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARLAFSSPLRVERREISLKTFPVLAKTDPLAEY
                     LPPADGGGPKADDDFAGLY"
                     /name="TraM recognition domain-containing protein"
     gene            7993..8724
                     /locus_tag="DVJ44_29570"
     CDS             7993..8724
                     /locus_tag="DVJ44_29570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UNM54906.1"
                     /translation="MTLEQYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRAKYPVDGRQVSVWGLTPHGVAFSFDEDEPLTDVIPFQP
                     SRVSAAQLPHRLAVQSLRLSMEGRGATGWRYLHRMALKGMKVPDALAELDGRTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRRANGIDEIWYICPDRPTLVRVQRAILAVDEIVNPQTGEA
                     RKTVELDRERLFACFKFMTTE"
                     /name="hypothetical protein"
     gene            8731..9261
                     /locus_tag="DVJ44_29575"
     CDS             8731..9261
                     /locus_tag="DVJ44_29575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UNM54907.1"
                     /translation="MALYMVFIEDVEDKDGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGENPQWERDKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIEVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(9288..9467)
                     /locus_tag="DVJ44_29580"
     CDS             complement(9288..9467)
                     /locus_tag="DVJ44_29580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="UNM54908.1"
                     /translation="MTKQEKTALNMAKFIKDQSLLLLEKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(9493..9921)
                     /locus_tag="DVJ44_29585"
     CDS             complement(9493..9921)
                     /locus_tag="DVJ44_29585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UNM54909.1"
                     /translation="MAKTLLNLSQAAQAAGITRRTLYNHVKQGKVTVSRDGKNNPVVDV
                     SELIRVYGNVNIPEKQIPGISHRENTQKNFPQEQLLAMQKELADLRQAVTLMLEDKTSR
                     EEERRQHDDERRKLQAEVDRLTTELTQKKKRFWSGWFS"
                     /name="hypothetical protein"
     BGC             1..9044
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          complement(4649..5227)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="98.282"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          7994..8721
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="93.416"
                     /coverage="100.0"
                     /evalue="1.34e-140"
ORIGIN
        1 gaattgcgcc cccgtcatcg gttattagag gctgtctgcc cccggatacc cggattcttt
       61 ctgatgcctg acggtgacga tcacaatctg gtccatttcc cggtcgtggc ggtagagcat
      121 cacatagcca ctgtcgccaa acccgatcac cagttcctta tattccagcg gcagaaacgg
      181 caccgggcgg ccaatgtctg gcaatgtttt cagttgctgg atagcccgga cgatcacctc
      241 acctcctttt ctggctgcca gccgattttt ggttttgaga aagtcctgaa ggcgttgtaa
      301 atcgcgctgt gccagcgcgg aaatcgttac ctgtggcatg gcggagcatc ctgctcgttc
      361 tcagttcccc aggtacttat ccaggcttcc gcttcttccg cagtaaggtg cagacccgtt
      421 tcctgatagt gctgccatgc ggcctgtccg tcccgcaggt actggctgcg cttctcttcc
      481 cggtcgatgt attcggtgat tgcctccagc attagcgcgt gcgctgagcg gtgccggtca
      541 tcggccagcg ttttcagccg gtccttaagt tcttcatcga gcctgatgga tgttgctgat
      601 gacataaaag cccctttgta gtcatatgta ttacacatga ctactttaat ccgtggcggc
      661 gctatttgcc agaaatacgg cttttgctgc ccatttttca gcttcgcttc cactaatcag
      721 ggctgctaca ggctcactca tcatccagga ctattgcagc ctgcgggtta aaggacctgt
      781 tactggcggc aaccatcatc attgagcttt tgggtggtga ctggtcgcgg atcctgtaag
      841 ccgtcatttt tcagactgaa ttcaaaattt ataacctgtc gcattgccgg gtgccctgcg
      901 ggatatagcc agtgcctcat tgccgtcagc gtttcccgaa aaaaaaggtg acagccggta
      961 agcgacacgt tgtccactcg tccatcgtcc agaatatcaa acgtggcggt cacctgacct
     1021 tcgatgcgtt ttgctgcggc ctgtaccggg taggttggct gcagtgtggt tacgggtttt
     1081 agtggtatcg catgtaccgg agtgaggaac atggccgcca gcactgtcag agtaaaagct
     1141 ttcatggtct gaaatccaga ggggcgtttt tgaatatttg ccaggtattt tcatccggtg
     1201 ccggcggaat tttggcgtgg gtaacggctg atattgctgc tttacagagt ttcggatctc
     1261 ctccttcagc aatggcgctg ttcagagtgc catcacgttg tatggatatc cgcacggtgc
     1321 acatttttcc cgcataggcc tctggttcaa acatctgcat ttcaacagcg gtcttgatgg
     1381 ccgcagcgta gctactgatt ttagatgact tatccagagt ataaattttc ggcggctggg
     1441 tggtggaatg cttacaggcc gtcaggagta aggggctgca caatgccagc aggataaagg
     1501 gtattaaacg catcgggttg atgacctgtc agtaaaaaat gttacatgta tatttgtcac
     1561 tctttacggc cacgttcatt tacataaaca cggcttatcg tatcgttttt acaccaaacg
     1621 gcccgccatg cagttgcgtg cataggcatg cagcgggtta caatttaccg ggcgcgtttc
     1681 cggcggtttt ccgggtggtt tgttgcctgt tttatcccgt agccgccgga aacgccctca
     1741 gaccgtctga gcggtgcggg caatgcgacg ttatggtaaa taccccttac cggcggcgct
     1801 gtggctgcca ggtgaaggtg gtttccgtag cctcgtattt ctcccgacgc atttcctgcg
     1861 cccgcctggc ttcacgttcg tcctgaatgg cacgaagcac cctttcccgc acctgttgtt
     1921 ttaccgcctt tggcagcgtt ttgttccctt tcaggcccat ggccagtgcc tgagcgacaa
     1981 aggcgtccgc caggcgcttt tcttcagcgg gagtcagttt caggtgcgtc atagtggcct
     2041 ccgggcgtct caggtttccc gaacagttta accgcaggtc ctctcctcat gccagttagc
     2101 tttcagatgt gtctatacca tctgaaatgt aagtgtgatg aatgtcttaa ataataaaat
     2161 ttgttgccat gagaaatttt cgggaaaaga cgcgatctgc ttacaggtgg ctccgggcgc
     2221 ttttttgtgc ctgaagatga gaactaatct catatattga cacctgaaaa cgggaggagt
     2281 aaggtaataa ttatactgtg tatatgtaca gtatgttggc tttaatttat tgttttaaat
     2341 gtcaaagagg aaaacggtat gagtggtgga gacggtcgag gtccgggtaa ttcaggtctg
     2401 ggacataatg gtggtcaggc cagtgggaat gtgaacggta cgtctggtaa aggtggccct
     2461 tcatcaggtg gtggtacgga tccaaacagc gggccgggct ggggtacgac gcatacgccg
     2521 aatggagata ttcataacta taatccgggg gagtttggta acggcgggag taaacccggt
     2581 ggtaatggtg gtaacagcgg caatcatagc ggtagctctg gtggcggaca gtcttcggcc
     2641 actgcgatgg ccttcggtct gcctgccctg gctactccgg gggctgaagg actggcttta
     2701 tcagtttccg gcgatgcgtt gtcggccgcc gttgctgatg tgctggctgc cctgaagggg
     2761 ccgtttaagt ttggtctgtg ggggattgcg atctacggtg tgctgccttc tgagattgca
     2821 aaagatgatc cgaaaatgat gtcaaaaatt atgacgtcat taccggccga tgcggtgacg
     2881 gagactccgg caagtacttt accactggac caggcgacgg ttcgtgtcag acaacgggtt
     2941 gtggatgtgg tgaaggatga gcggcagcat attgcggttg tcgcaggtcg gccaatgagt
     3001 gtccctgtgg tggatgcgaa accgacaaaa cgtccggggg tattcagtgt gtcgattccg
     3061 ggtctcccgt ctctgcaggt gagcgtaccg aaaggtgttc cgacagcgaa agccccgcca
     3121 aaaggcattg ttgctgaaaa aggtgattca cgtccggctg gttttacagc cggtggtaac
     3181 tcccgtgagg ccgttattcg tttcccgaaa gagaccggac agaagccggt ttatgtgtcg
     3241 gtgacagatg ttcttacccc ggcacaggta aaacagcgtc aggaggaaga aaagcgtcgc
     3301 cagcaggcat gggacgccgc tcatccggaa gaggggctga aaagagacta tgataaagcg
     3361 aaagctgagc tggatgccga agataaaaat attgcgacct taaacagccg cattgcatcg
     3421 acagagaagg cgctccccgg tgcaagggct gctgttcagg aagccgataa aaaggtaaaa
     3481 gaggcagagg caaataaaga tgattttgtg acttataacc cgcctcatga atatggctcc
     3541 gggtggcagg atcaggttcg ctatcttgat aaggatattc agaatcagaa tgagaaatta
     3601 aaagcggctc aggcatcttt aaacgcaatg aatgaatcct tatccagaga taaggctgca
     3661 cttaccgggg cgatggagag ccggaaacaa aaggagaaaa aagcgaagga tgcagaaaat
     3721 aagttaaatg aggaaaagaa caagcctcgc aaggggacta aagactacgg ccatgattat
     3781 catccagtac ctaaaacaga agacataaag ggacttggag agttaaagcg aggtgatcct
     3841 aaaacaccta aacaaggtgg tggtggtaag cgggcccgat ggtatggcga taaaaaacgt
     3901 aaaatttatg aatgggattc ccagcacggt gagcttgaag ggtatcgtgc cagtgatggc
     3961 gaacacctag gcgcatttga tcccaaaacg ggtaagcagg ttaaagggcc agatccaaaa
     4021 cggaacatta aaaaatatct ttgagaggta aatatggggc ttaaattacg tttgacatgg
     4081 tttgataaga aaactgaaga gtttaaaggg gaagagtatt ctaaagactt tggtgacgat
     4141 ggttctgtca ttgaaagctt gggaatgcct ttaaaggata atattaataa tggtgagttt
     4201 gatttgaaga aagaatgggt tcctttacta cagccatttt ttaaaaatca aataaaacct
     4261 gatgtggata attgttatat agcttttgat tatcgggacg gtaactggta acaaaaaatt
     4321 atcaaggatg atttgaaata ctgacttccg gtgttcaggg atgaatgccg gagtctttaa
     4381 atacagggaa agtatatgaa aaaggtaaag actatttttc tttttatatt gattgttgct
     4441 ggctttcttc tggccgcatg tcaggcaaat tatatccggg atgttcaggg cggaacggtg
     4501 gcaccatcgt cctcctctga actgacgggg atcgcggttc agtagaaaag atcaaaggat
     4561 cttcttgaga tccttttttt ctgcgcgtaa tcttttgccc tgtaaacgaa aaaaccacct
     4621 ggggaggtgg tttgatcgaa ggttaagtca gttggggaac tgcttaaccg tggtaactgg
     4681 ctttcgcaga gcacagcaac caaatctgtc cttccagtgt agccggactt tggcgcacac
     4741 ttcaagagca accgcgtgtt tagctaaaca aatcctctgc gaactcccag ttaccaatgg
     4801 ctgctgccag tggcgttttg cgtgctttcc cgggttggac tcaagtgaac agttaccgga
     4861 taaggcgcag cagtcgggct gaacggggag ttcttgctta cagcccagct tggagcgaac
     4921 gacctacacc gagccgagat accagtgtgt gagctatgag aaagcgccac acttcccgca
     4981 agggagaacg gcggacaggt atccggtaaa cggcagggtc ggaacaggag agcgcaagag
     5041 ggagcgacct accggaaacg gtggggatct ttaagtcctg tcgggtttcg cccgtactgt
     5101 cagattcatg gttgagcctc acggctccca cagatgcacc gaaaaagcgt ctgtttatgt
     5161 gaactctggc aggagggcgg agcctatgga aaaacgccac cggcgcggcc ctgccgtttt
     5221 gcctcacatg ttagtcccct gcttatccac ggaatctgtg ggtaactttg tatgtgtccg
     5281 cagcgcccgc cgcagtctca cgcccggagc gtagcgaccg agtgagcgag gaggcgcaat
     5341 ttccccggca cctgcaagac ggtcaccgga cgcgctgatg tgggatattg tcccctgatt
     5401 aagtctttct attccctgac gatcaattat caggataggt gaaccatgtc ggtttttcgc
     5461 tgaacatttt acgttaacct atctctgttg cttttttctc cttgcggaga aatgcaagtc
     5521 atccccgctg gggcgtggct gacttcaggg gaaaagacct tgcttacgct ggctggacgc
     5581 caccgacgca cggtcttttc ccctctttct ggctctgtcc ggctggacgc cggccacgcc
     5641 agaaattcac ccggcccccg tcaggctcac gcctgaccac ccacaaaaat ccacggtgct
     5701 ggacgcacct gacgaagcag caaagctgct cctgattttg cgggtggtca gccgctcgct
     5761 atggcgaact ctgacggggg ccggaacacc ggaaaagacc gcactggggt gccgcctttt
     5821 cctctcacac gctggggcgt gctcgttgtt cctccggggc tgcgcctttt ccgcatgggg
     5881 cggaaagagg ctggcctccg cggtgaaagc tgaacgcaat caccacggac gtgaccgccg
     5941 ccgccatgcc ttggggcatg tccgcggctt gtgcagcggg ggctgcgcat cacgccggta
     6001 aacccgtcgt ctgaaggaga gagattgcat gtttaatacg gattcgcttg cctggcagtg
     6061 gcatatcccg gagctggccc ggcagattta cccgtgggtc agctggctgt accgggagta
     6121 ttacagtctg gccggttttt ttctggttat cggcctgttt ttcggtctgg ctgaactctg
     6181 ggccggccga atgcgttttg tggggctgag ccataaggcg cggcgggagt atgccgatcg
     6241 ctataagcgc gataataacc ggactgtgcc attttcggtg ctggcctcgc tggattcacc
     6301 cgggcggatg gtcagggcac ggcgacatgt ctggaactac gcgtactggc tgaccggcgc
     6361 tgccggtctg gcccttctgg gggggctggt tgtcgccgtg tttatcgaga gctggggaga
     6421 aaccgtcctg cgcccggacc tctatgcgaa cgcagattat tacctgctgc agccggctaa
     6481 cctgttcggg atagcctggt gtgccggagg gcttgtcgcc ggcgtccttc tggcgcggct
     6541 gctggcgttc ctgctgcttg atggtcattt tgcggccgct gacgaggcgg tgaacgcgaa
     6601 actgaatcag gagagccggc gcagcagcca gcggaccgga gaaatgacag acgtccgcca
     6661 cctgcatttc ggggagccgg taccggttaa cgcgctggcc gatttttcca cggagcaggc
     6721 ccggaaacag caggcggtgt ttctgggtaa ggatgagcag ggccagccgg tgctggtccc
     6781 tcgtgatacc tggcgcaaga ccaatattca gatcctcggc ctgcccggga gcggcaagag
     6841 cgcgatggcc accaacgcgc tcattcgctg cgtacgcgat ttcggggacg ctgtggtgta
     6901 cttcgacccc aaaggggacg cgtgggcgcc gcacgtcttc cgggcgcact gcccggactt
     6961 caccctgctg gatctgcggc cggggaaacc ggcgcagctg aatctgttcc gcgatctcga
     7021 ccagtacgcc ctgaagaatc tgctggttgc cgggtttaac ctgagtgaga ccggcgacgt
     7081 ggcggaccac taccgcatca gcgagcagaa agcggcgaag ctgattgcgg agcagttccc
     7141 gcagggggca aacattcagc aggtgctggc ggcggcgtac gcgttgccgg aggccctgaa
     7201 aaaggacgtg aaggggctga tcaccaagct ggagaacgtg gccgacctga gcgtcctgca
     7261 gacggacagc ggtatcgatg tggcggggat aatcaacggc ggcggctgcc tgtacgtcat
     7321 cggctcgatg gacgatgagg cggtgatccg ggtgcagaag atgctgtttg cccgctgcgc
     7381 gcaaatcatc attgcgcggg atgagttccg gaggtggccg cacgcgagca tcatgctcga
     7441 tgagattaaa tatctgctgt cgaagtacgt gctgaacgcg ctggggacgc tgcgcagccg
     7501 ggactgcaac ctgctgctcg cgcaccagtc gctgggcgac ttcggtcagt gcgggcagga
     7561 tctgcccgct gattttgtga aaaccacggt actggataac acgccgatcc gctggttcta
     7621 tcgcgcggcc agccaggagt ccgcgcagtg ggcggcgggc cagaccgggg agatccgggt
     7681 ggacgtggag cgccgccggg ccagccggga ggcggggaac gtggagcaca tcagcggcga
     7741 cagcttcatc cagaaggagg cgcggccgct gtttgacgtg aacaccctgc aacacctgcc
     7801 tgacgggttc gcggtgatga ccgggctggg cgtggcgcgg ctggcgttca gcagcccgct
     7861 gcgggttgag cgccgggaaa tttcgctgaa aaccttcccg gtgctggcga aaacggaccc
     7921 gctggcggag tacctgcctc cggccgacgg cggcggacca aaagcggatg atgattttgc
     7981 ggggctttac tgatgacact ggagcagtac aacgtcagcc acgcgaagcg gcaggcgcgg
     8041 aacgcggaga aaacacggct gaccctgcgc tggctgcggg aagagctgtg ttccacggcg
     8101 gagctggttg cgcgacggct ggggattgcg gcggtacagc cggtttaccg cttcctggac
     8161 agtctggtgg cgaaagggct gctggtccgg gcgaaatacc cggttgacgg ccgtcaggtc
     8221 agcgtgtggg ggctgacgcc gcacggggtg gcgttctcgt tcgacgagga cgagccgctg
     8281 acggacgtta ttccgtttca gccgtcaagg gtgtcggcgg cgcagctgcc gcaccggctg
     8341 gccgtgcagt ccctgcgcct ctccatggag ggccgggggg ccaccggctg gcggtacctg
     8401 caccgtatgg ccctgaaagg gatgaaagtg ccggacgcgc tggcggagct ggacggcaga
     8461 acggtggcat ttgaggtaga gcgcaccgtc aagagccgca ggcggtatca ggaagtggtg
     8521 tccgggtatc tgttcaaccg ccgggcgaac ggcatcgatg aaatctggta catctgccct
     8581 gaccggccga cgcttgtccg ggtacagcgg gcgattctgg cggtggatga aatcgtgaat
     8641 ccacagaccg gcgaggcccg caaaacggtg gagctggacc gggagaggct gttcgcgtgc
     8701 tttaaattta tgacaacgga gtgagggatt atggcgctgt acatggtatt tattgaggac
     8761 gtggaagaca aagacggcga gcgctgcatt atgccaacca gcgagcatct ggaagacatg
     8821 gtggtgctcg cctggcagac cggggcgtat gttttctgtt ttgtcgaccg ggcccagcat
     8881 ctggcgatga tgaaatccat cgggatgtat gacgagcggc tcaacagcga cgaaaaagcc
     8941 acgtactttt tcaccggtga aaatccgcaa tgggaacggg acaaacccac aggaatgaag
     9001 ctgtgtgatt acctctatcg aaaggtggag cggttcgcca tcgagaacgg tgtgcaggtg
     9061 gttgatgccg ggaagtgctc accggagcag attaacgcga tgattgaggt ggtcagcgag
     9121 cggcacgggg aaagcgcggt gaacgagaag ctgaaagcgg agctgatgcg ggaatataac
     9181 agccgctatt ttaacgtgcc ggtgcctgaa ctgccggagg acaaacccgc ccgccggtgg
     9241 tggccgttcg gcaaaaaata acgccagcac cggcatggcc ggtgctgtta ttcttccccg
     9301 agcttatccc gcatcacctg ccagagtgtt tccgcatcct cgtgaagccg ttcgcacatg
     9361 tcggccgggg tatccatgtc cagctcgttc agcttttcca gcaacagcag cgactgatcc
     9421 ttaatgaatt tagccatatt gagggcagtt ttttcctgct tcgtcatgtt ctccattccc
     9481 ttcggtaagt tctcagctaa accagccgga ccagaagcgt tttttcttct gtgtcagttc
     9541 tgttgtcaat ctgtccactt cggcctggag tttccggcgc tcatcatcgt gctggcggcg
     9601 ttcttcttcc cgggatgttt tatcttccag catcagggtg acagcctgcc ggagatcggc
     9661 cagttccttt tgcattgcca gaagctgttc ctgtgggaaa tttttttgtg tattttcacg
     9721 gtgtgaaatg ccgggaattt gtttctcagg gatattcaca tttccgtata cacggatcag
     9781 ttctgacaca tccacgacag ggttgttttt cccgtcacgt gacacggtaa cctttccctg
     9841 ttttacatga ttgtatagcg ttcttctggt aatgcccgcg gcttgtgctg cctgtgaaag
     9901 gttgagcaat gttttcgcca ctgtataccc ctgattttat cgggtgtgaa aggtgtgtaa
     9961 tttctcacgg taaatgtatc gctgaatttt acccgttttt ccgttcagga tgtggttttc
    10021 tgacgcgctg cgcttgtcaa accggcgacg gccacgcaat
//
