LOCUS       CP043367               10060 bp    DNA     circular BCT 14-MAR-2022
DEFINITION  Klebsiella pneumoniae strain WCHKP090045 plasmid p1_090045, complete
            sequence.
ACCESSION   CP043367
VERSION     CP043367.1
DBLINK      BioProject: PRJNA353728
            BioSample: SAMN09842413
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 10060)
  AUTHORS   Wei,L., Long,H., Feng,Y. and Zong,Z.
  TITLE     The complete genome of Klebsiella pneumoniae strain WCHKP090045
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10060)
  AUTHORS   Wei,L., Long,H., Feng,Y. and Zong,Z.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-AUG-2019) Center of Infectious Diseases, West China
            Hospital, Sichuan University, Guoxuexiang 37, Chengdu, Sichuan
            610041, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.7
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/27/2019 13:19:54
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Annotation Software revision      :: 4.9
            Genes (total)                     :: 5,647
            CDSs (total)                      :: 5,525
            Genes (coding)                    :: 5,373
            CDSs (with protein)               :: 5,373
            Genes (RNA)                       :: 122
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 11
            Pseudo Genes (total)              :: 152
            CDSs (without protein)            :: 152
            Pseudo Genes (ambiguous residues) :: 0 of 152
            Pseudo Genes (frameshifted)       :: 57 of 152
            Pseudo Genes (incomplete)         :: 94 of 152
            Pseudo Genes (internal stop)      :: 26 of 152
            Pseudo Genes (multiple problems)  :: 22 of 152
            ##Genome-Annotation-Data-END##
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..10060
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="WCHKP090045"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="p1_090045"
                     /geo_loc_name="China: Chengdu, Sichuan"
                     /collection_date="2017"
     gene            497..802
                     /locus_tag="D0S90_28125"
     CDS             497..802
                     /locus_tag="D0S90_28125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UNC74161.1"
                     /translation="MLDAPDEAAKLLLILRVVSRSLWRTLTGAGTPEKTALGCRLFLSH
                     AGACSLFLRGCAFSAWGGKRLASAVKAERNHHGRDRRRHALGHVRGLCSGGCASRR"
                     /name="hypothetical protein"
     gene            830..2794
                     /locus_tag="D0S90_28130"
     CDS             830..2794
                     /locus_tag="D0S90_28130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="UNC74162.1"
                     /translation="MFNTDSLAWQWHIPELARQIYPWVSWLYREYYSLAGFFLVIGLFF
                     GLAELWAGRMRFVGLSHKARREYADRYKRDNNRTVPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLV
                     AGVLLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSTEQARKQQAVFLGKDEQGQPVLVPRDTWRKTNIQILGLPGSGKSAMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLV
                     AGFNLSETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     KLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFRRWPHASIMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPADFV
                     KTTVLDNTPIRWFYRAASQESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARLAFSSPLRVERREISLKTFPVLAKTDPLAEY
                     LPPADGGGPKADDDFAGLY"
                     /name="TraM recognition domain-containing protein"
     gene            2794..3525
                     /locus_tag="D0S90_28135"
     CDS             2794..3525
                     /locus_tag="D0S90_28135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UNC74163.1"
                     /translation="MTLEQYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRAKYPVDGRQVSVWGLTPHGVAFSFDEDEPLTDVIPFQP
                     SRVSAAQLPHRLAVQSLRLSMEGRGATGWRYLHRMALKGMKVPDALAELDGRTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRRANGIDEIWYICPDRPTLVRVQRAILAVDEIVNPQTGEA
                     RKTVELDRERLFACFKFMTTE"
                     /name="hypothetical protein"
     gene            3532..4062
                     /locus_tag="D0S90_28140"
     CDS             3532..4062
                     /locus_tag="D0S90_28140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UNC74164.1"
                     /translation="MALYMVFIEDVEDKDGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGENPQWERDKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIEVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(4089..4268)
                     /locus_tag="D0S90_28145"
     CDS             complement(4089..4268)
                     /locus_tag="D0S90_28145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="UNC74165.1"
                     /translation="MTKQEKTALNMAKFIKDQSLLLLEKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(4294..4722)
                     /locus_tag="D0S90_28150"
     CDS             complement(4294..4722)
                     /locus_tag="D0S90_28150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UNC74166.1"
                     /translation="MAKTLLNLSQAAQAAGITRRTLYNHVKQGKVTVSRDGKNNPVVDV
                     SELIRVYGNVNIPEKQIPGISHRENTQKNFPQEQLLAMQKELADLRQAVTLMLEDKTSR
                     EEERRQHDDERRKLQAEVDRLTTELTQKKKRFWSGWFS"
                     /name="hypothetical protein"
     gene            complement(4886..5200)
                     /locus_tag="D0S90_28155"
     CDS             complement(4886..5200)
                     /locus_tag="D0S90_28155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001136729.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="UNC74167.1"
                     /translation="MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKT
                     LPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDREMDQIVIVTVRHQKESGYPGADSL
                     "
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(5188..5466)
                     /locus_tag="D0S90_28160"
     CDS             complement(5188..5466)
                     /locus_tag="D0S90_28160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019952150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribbon-helix-helix protein, CopG family"
                     /protein_id="UNC74168.1"
                     /translation="MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEK
                     RSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWGTENEQDAPPCHR"
                     /name="ribbon-helix-helix protein, CopG family"
     gene            complement(5641..6006)
                     /locus_tag="D0S90_28165"
     CDS             complement(5641..6006)
                     /locus_tag="D0S90_28165"
                     /inference="COORDINATES: protein motif:HMM:TIGR01352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TonB family protein"
                     /protein_id="UNC74169.1"
                     /translation="MKAFTLTVLAAMFLTPVHAIPLKPVTTLQPTYPVQAAAKRIEGQV
                     TATFDILDDGRVDNVSLTGCHLFFRETLTAMRHWLYPAGHPAMRQVINFEFSLKNDGLQ
                     DPRPVTTQKLNDDGCRQ"
                     /name="TonB family protein"
     gene            complement(6003..6374)
                     /gene="tolA"
                     /locus_tag="D0S90_28170"
     CDS             complement(6003..6374)
                     /gene="tolA"
                     /locus_tag="D0S90_28170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001237044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell envelope integrity protein TolA"
                     /protein_id="UNC74170.1"
                     /translation="MRLIPFILLALCSPLLLTACKHSTTQPPKIYTLDKSSKISSYAAA
                     IKTAVEMQMFEPEAYAGKMCTVRISIQRDGTLNSAIAEGGDPKLCKAAISAVTHAKIPP
                     APDENTWQIFKNAPLDFRP"
                     /name="tolA"
     gene            complement(6648..6893)
                     /locus_tag="D0S90_28175"
     CDS             complement(6648..6893)
                     /locus_tag="D0S90_28175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146442.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="UNC74171.1"
                     /translation="MTHLKLTPAEEKRLADAFVAQALAMGLKGNKTLPKAVKQQVRERV
                     LRAIQDEREARRAQEMRREKYEATETTFTWQPQRRR"
                     /name="hypothetical protein"
     gene            7220..8905
                     /locus_tag="D0S90_28180"
     CDS             7220..8905
                     /locus_tag="D0S90_28180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="UNC74172.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IMTSLPADAVTETPASTLPLDQATVRVRQRVVDVVKDERQHIAVVAGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPTAKAPPKGIVAEKGDSRPAGFTAGGNSREAVIR
                     FPKETGQKPVYVSVTDVLTPAQVKQRQEEEKRRQQAWDAAHPEEGLKRDYDKAKAELDA
                     EDKNIATLNSRIASTEKALPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQASLNAMNESLSRDKAALTGAMESRKQKEKKAKDAENKLNE
                     EKNKPRKGTKDYGHDYHPVPKTEDIKGLGELKRGDPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="cloacin"
     gene            8915..9172
                     /locus_tag="D0S90_28185"
     CDS             8915..9172
                     /locus_tag="D0S90_28185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="UNC74173.1"
                     /translation="MGLKLRLTWFDKKTEEFKGEEYSKDFGDDGSVIESLGMPLKDNIN
                     NGEFDLKKEWVPLLQPFFKNQIKPDVDNCYIAFDYRDGNW"
                     /name="cloacin"
     gene            9257..9406
                     /locus_tag="D0S90_28190"
     CDS             9257..9406
                     /locus_tag="D0S90_28190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lysis protein"
                     /protein_id="UNC74174.1"
                     /translation="MKKVKTIFLFILIVAGFLLAACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="lysis protein"
     BGC             2220..10060
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          complement(9510..10060)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="98.375"
                     /coverage="95.0"
                     /evalue="0.0"
     Typing          2795..3522
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="93.416"
                     /coverage="100.0"
                     /evalue="1.34e-140"
ORIGIN
        1 ccggcgcggc cctgccgttt tgcctcacat gttagtcccc tgcttatcca cggaatctgt
       61 gggtaacttt gtatgtgtcc gcagcgcccg ccgcagtctc acgcccggag cgtagcgacc
      121 gagtgagcga ggaggcgcaa tttccccggc acctgcaaga cggtcaccgg acgcgctgat
      181 gtgggatatt gtcccctgat taagtctttc tattccctga cgatcaatta tcaggatagg
      241 tgaaccatgt cggtttttcg ctgaacattt tacgttaacc tatctctgtt gcttttttct
      301 ccttgcggag aaatgcaagt catccccgct ggggcgtggc tgacttcagg ggaaaagacc
      361 ttgcttacgc tggctggacg ccaccgacgc acggtctttt cccctctttc tggctctgtc
      421 cggctggacg ccggccacgc cagaaattca cccggccccc gtcaggctca cgcctgacca
      481 cccacaaaaa tccacggtgc tggacgcacc tgacgaagca gcaaagctgc tcctgatttt
      541 gcgggtggtc agccgctcgc tatggcgaac tctgacgggg gccggaacac cggaaaagac
      601 cgcactgggg tgccgccttt tcctctcaca cgctggggcg tgctcgttgt tcctccgggg
      661 ctgcgccttt tccgcatggg gcggaaagag gctggcctcc gcggtgaaag ctgaacgcaa
      721 tcaccacgga cgtgaccgcc gccgccatgc cttggggcat gtccgcggct tgtgcagcgg
      781 gggctgcgca tcacgccggt aaacccgtcg tctgaaggag agagattgca tgtttaatac
      841 ggattcgctt gcctggcagt ggcatatccc ggagctggcc cggcagattt acccgtgggt
      901 cagctggctg taccgggagt attacagtct ggccggtttt tttctggtta tcggcctgtt
      961 tttcggtctg gctgaactct gggccggccg aatgcgtttt gtggggctga gccataaggc
     1021 gcggcgggag tatgccgatc gctataagcg cgataataac cggactgtgc cattttcggt
     1081 gctggcctcg ctggattcac ccgggcggat ggtcagggca cggcgacatg tctggaacta
     1141 cgcgtactgg ctgaccggcg ctgccggtct ggcccttctg ggggggctgg ttgtcgccgt
     1201 gtttatcgag agctggggag aaaccgtcct gcgcccggac ctctatgcga acgcagatta
     1261 ttacctgctg cagccggcta acctgttcgg gatagcctgg tgtgccggag ggcttgtcgc
     1321 cggcgtcctt ctggcgcggc tgctggcgtt cctgctgctt gatggtcatt ttgcggccgc
     1381 tgacgaggcg gtgaacgcga aactgaatca ggagagccgg cgcagcagcc agcggaccgg
     1441 agaaatgaca gacgtccgcc acctgcattt cggggagccg gtaccggtta acgcgctggc
     1501 cgatttttcc acggagcagg cccggaaaca gcaggcggtg tttctgggta aggatgagca
     1561 gggccagccg gtgctggtcc ctcgtgatac ctggcgcaag accaatattc agatcctcgg
     1621 cctgcccggg agcggcaaga gcgcgatggc caccaacgcg ctcattcgct gcgtacgcga
     1681 tttcggggac gctgtggtgt acttcgaccc caaaggggac gcgtgggcgc cgcacgtctt
     1741 ccgggcgcac tgcccggact tcaccctgct ggatctgcgg ccggggaaac cggcgcagct
     1801 gaatctgttc cgcgatctcg accagtacgc cctgaagaat ctgctggttg ccgggtttaa
     1861 cctgagtgag accggcgacg tggcggacca ctaccgcatc agcgagcaga aagcggcgaa
     1921 gctgattgcg gagcagttcc cgcagggggc aaacattcag caggtgctgg cggcggcgta
     1981 cgcgttgccg gaggccctga aaaaggacgt gaaggggctg atcaccaagc tggagaacgt
     2041 ggccgacctg agcgtcctgc agacggacag cggtatcgat gtggcgggga taatcaacgg
     2101 cggcggctgc ctgtacgtca tcggctcgat ggacgatgag gcggtgatcc gggtgcagaa
     2161 gatgctgttt gcccgctgcg cgcaaatcat cattgcgcgg gatgagttcc ggaggtggcc
     2221 gcacgcgagc atcatgctcg atgagattaa atatctgctg tcgaagtacg tgctgaacgc
     2281 gctggggacg ctgcgcagcc gggactgcaa cctgctgctc gcgcaccagt cgctgggcga
     2341 cttcggtcag tgcgggcagg atctgcccgc tgattttgtg aaaaccacgg tactggataa
     2401 cacgccgatc cgctggttct atcgcgcggc cagccaggag tccgcgcagt gggcggcggg
     2461 ccagaccggg gagatccggg tggacgtgga gcgccgccgg gccagccggg aggcggggaa
     2521 cgtggagcac atcagcggcg acagcttcat ccagaaggag gcgcggccgc tgtttgacgt
     2581 gaacaccctg caacacctgc ctgacgggtt cgcggtgatg accgggctgg gcgtggcgcg
     2641 gctggcgttc agcagcccgc tgcgggttga gcgccgggaa atttcgctga aaaccttccc
     2701 ggtgctggcg aaaacggacc cgctggcgga gtacctgcct ccggccgacg gcggcggacc
     2761 aaaagcggat gatgattttg cggggcttta ctgatgacac tggagcagta caacgtcagc
     2821 cacgcgaagc ggcaggcgcg gaacgcggag aaaacacggc tgaccctgcg ctggctgcgg
     2881 gaagagctgt gttccacggc ggagctggtt gcgcgacggc tggggattgc ggcggtacag
     2941 ccggtttacc gcttcctgga cagtctggtg gcgaaagggc tgctggtccg ggcgaaatac
     3001 ccggttgacg gccgtcaggt cagcgtgtgg gggctgacgc cgcacggggt ggcgttctcg
     3061 ttcgacgagg acgagccgct gacggacgtt attccgtttc agccgtcaag ggtgtcggcg
     3121 gcgcagctgc cgcaccggct ggccgtgcag tccctgcgcc tctccatgga gggccggggg
     3181 gccaccggct ggcggtacct gcaccgtatg gccctgaaag ggatgaaagt gccggacgcg
     3241 ctggcggagc tggacggcag aacggtggca tttgaggtag agcgcaccgt caagagccgc
     3301 aggcggtatc aggaagtggt gtccgggtat ctgttcaacc gccgggcgaa cggcatcgat
     3361 gaaatctggt acatctgccc tgaccggccg acgcttgtcc gggtacagcg ggcgattctg
     3421 gcggtggatg aaatcgtgaa tccacagacc ggcgaggccc gcaaaacggt ggagctggac
     3481 cgggagaggc tgttcgcgtg ctttaaattt atgacaacgg agtgagggat tatggcgctg
     3541 tacatggtat ttattgagga cgtggaagac aaagacggcg agcgctgcat tatgccaacc
     3601 agcgagcatc tggaagacat ggtggtgctc gcctggcaga ccggggcgta tgttttctgt
     3661 tttgtcgacc gggcccagca tctggcgatg atgaaatcca tcgggatgta tgacgagcgg
     3721 ctcaacagcg acgaaaaagc cacgtacttt ttcaccggtg aaaatccgca atgggaacgg
     3781 gacaaaccca caggaatgaa gctgtgtgat tacctctatc gaaaggtgga gcggttcgcc
     3841 atcgagaacg gtgtgcaggt ggttgatgcc gggaagtgct caccggagca gattaacgcg
     3901 atgattgagg tggtcagcga gcggcacggg gaaagcgcgg tgaacgagaa gctgaaagcg
     3961 gagctgatgc gggaatataa cagccgctat tttaacgtgc cggtgcctga actgccggag
     4021 gacaaacccg cccgccggtg gtggccgttc ggcaaaaaat aacgccagca ccggcatggc
     4081 cggtgctgtt attcttcccc gagcttatcc cgcatcacct gccagagtgt ttccgcatcc
     4141 tcgtgaagcc gttcgcacat gtcggccggg gtatccatgt ccagctcgtt cagcttttcc
     4201 agcaacagca gcgactgatc cttaatgaat ttagccatat tgagggcagt tttttcctgc
     4261 ttcgtcatgt tctccattcc cttcggtaag ttctcagcta aaccagccgg accagaagcg
     4321 ttttttcttc tgtgtcagtt ctgttgtcaa tctgtccact tcggcctgga gtttccggcg
     4381 ctcatcatcg tgctggcggc gttcttcttc ccgggatgtt ttatcttcca gcatcagggt
     4441 gacagcctgc cggagatcgg ccagttcctt ttgcattgcc agaagctgtt cctgtgggaa
     4501 atttttttgt gtattttcac ggtgtgaaat gccgggaatt tgtttctcag ggatattcac
     4561 atttccgtat acacggatca gttctgacac atccacgaca gggttgtttt tcccgtcacg
     4621 tgacacggta acctttccct gttttacatg attgtatagc gttcttctgg taatgcccgc
     4681 ggcttgtgct gcctgtgaaa ggttgagcaa tgttttcgcc actgtatacc cctgatttta
     4741 tcgggtgtga aaggtgtgta atttctcacg gtaaatgtat cgctgaattt tacccgtttt
     4801 tccgttcagg atgtggtttt ctgacgcgct gcgcttgtca aaccggcgac ggccacgcaa
     4861 tgaattgcgc ccccgtcatc ggttattaga ggctgtctgc ccccggatac ccggattctt
     4921 tctgatgcct gacggtgacg atcacaatct ggtccatttc ccggtcgtgg cggtagagca
     4981 tcacatagcc actgtcgcca aacccgatca ccagttcctt atattccagc ggcagaaacg
     5041 gcaccgggcg gccaatgtct ggcaatgttt tcagttgctg gatagcccgg acgatcacct
     5101 cacctccttt tctggctgcc agccgatttt tggttttgag aaagtcctga aggcgttgta
     5161 aatcgcgctg tgccagcgcg gaaatcgtta cctgtggcat ggcggagcat cctgctcgtt
     5221 ctcagttccc caggtactta tccaggcttc cgcttcttcc gcagtaaggt gcagacccgt
     5281 ttcctgatag tgctgccatg cggcctgtcc gtcccgcagg tactggctgc gcttctcttc
     5341 ccggtcgatg tattcggtga ttgcctccag cattagcgcg tgcgctgagc ggtgccggtc
     5401 atcggccagc gttttcagcc ggtccttaag ttcttcatcg agcctgatgg atgttgctga
     5461 tgacataaaa gcccctttgt agtcatatgt attacacatg actactttaa tccgtggcgg
     5521 cgctatttgc cagaaatacg gcttttgctg cccatttttc agcttcgctt ccactaatca
     5581 gggctgctac aggctcactc atcatccagg actattgcag cctgcgggtt aaaggacctg
     5641 ttactggcgg caaccatcat cattgagctt ttgggtggtg actggtcgcg gatcctgtaa
     5701 gccgtcattt ttcagactga attcaaaatt tataacctgt cgcattgccg ggtgccctgc
     5761 gggatatagc cagtgcctca ttgccgtcag cgtttcccga aaaaaaaggt gacagccggt
     5821 aagcgacacg ttgtccactc gtccatcgtc cagaatatca aacgtggcgg tcacctgacc
     5881 ttcgatgcgt tttgctgcgg cctgtaccgg gtaggttggc tgcagtgtgg ttacgggttt
     5941 tagtggtatc gcatgtaccg gagtgaggaa catggccgcc agcactgtca gagtaaaagc
     6001 tttcatggtc tgaaatccag aggggcgttt ttgaatattt gccaggtatt ttcatccggt
     6061 gccggcggaa ttttggcgtg ggtaacggct gatattgctg ctttacagag tttcggatct
     6121 cctccttcag caatggcgct gttcagagtg ccatcacgtt gtatggatat ccgcacggtg
     6181 cacatttttc ccgcataggc ctctggttca aacatctgca tttcaacagc ggtcttgatg
     6241 gccgcagcgt agctactgat tttagatgac ttatccagag tataaatttt cggcggctgg
     6301 gtggtggaat gcttacaggc cgtcaggagt aaggggctgc acaatgccag caggataaag
     6361 ggtattaaac gcatcgggtt gatgacctgt cagtaaaaaa tgttacatgt atatttgtca
     6421 ctctttacgg ccacgttcat ttacataaac acggcttatc gtatcgtttt tacaccaaac
     6481 ggcccgccat gcagttgcgt gcataggcat gcagcgggtt acaatttacc gggcgcgttt
     6541 ccggcggttt tccgggtggt ttgttgcctg ttttatcccg tagccgccgg aaacgccctc
     6601 agaccgtctg agcggtgcgg gcaatgcgac gttatggtaa atacccctta ccggcggcgc
     6661 tgtggctgcc aggtgaaggt ggtttccgta gcctcgtatt tctcccgacg catttcctgc
     6721 gcccgcctgg cttcacgttc gtcctgaatg gcacgaagca ccctttcccg cacctgttgt
     6781 tttaccgcct ttggcagcgt tttgttccct ttcaggccca tggccagtgc ctgagcgaca
     6841 aaggcgtccg ccaggcgctt ttcttcagcg ggagtcagtt tcaggtgcgt catagtggcc
     6901 tccgggcgtc tcaggtttcc cgaacagttt aaccgcaggt cctctcctca tgccagttag
     6961 ctttcagatg tgtctatacc atctgaaatg taagtgtgat gaatgtctta aataataaaa
     7021 tttgttgcca tgagaaattt tcgggaaaag acgcgatctg cttacaggtg gctccgggcg
     7081 cttttttgtg cctgaagatg agaactaatc tcatatattg acacctgaaa acgggaggag
     7141 taaggtaata attatactgt gtatatgtac agtatgttgg ctttaattta ttgttttaaa
     7201 tgtcaaagag gaaaacggta tgagtggtgg agacggtcga ggtccgggta attcaggtct
     7261 gggacataat ggtggtcagg ccagtgggaa tgtgaacggt acgtctggta aaggtggccc
     7321 ttcatcaggt ggtggtacgg atccaaacag cgggccgggc tggggtacga cgcatacgcc
     7381 gaatggagat attcataact ataatccggg ggagtttggt aacggcggga gtaaacccgg
     7441 tggtaatggt ggtaacagcg gcaatcatag cggtagctct ggtggcggac agtcttcggc
     7501 cactgcgatg gccttcggtc tgcctgccct ggctactccg ggggctgaag gactggcttt
     7561 atcagtttcc ggcgatgcgt tgtcggccgc cgttgctgat gtgctggctg ccctgaaggg
     7621 gccgtttaag tttggtctgt gggggattgc gatctacggt gtgctgcctt ctgagattgc
     7681 aaaagatgat ccgaaaatga tgtcaaaaat tatgacgtca ttaccggccg atgcggtgac
     7741 ggagactccg gcaagtactt taccactgga ccaggcgacg gttcgtgtca gacaacgggt
     7801 tgtggatgtg gtgaaggatg agcggcagca tattgcggtt gtcgcaggtc ggccaatgag
     7861 tgtccctgtg gtggatgcga aaccgacaaa acgtccgggg gtattcagtg tgtcgattcc
     7921 gggtctcccg tctctgcagg tgagcgtacc gaaaggtgtt ccgacagcga aagccccgcc
     7981 aaaaggcatt gttgctgaaa aaggtgattc acgtccggct ggttttacag ccggtggtaa
     8041 ctcccgtgag gccgttattc gtttcccgaa agagaccgga cagaagccgg tttatgtgtc
     8101 ggtgacagat gttcttaccc cggcacaggt aaaacagcgt caggaggaag aaaagcgtcg
     8161 ccagcaggca tgggacgccg ctcatccgga agaggggctg aaaagagact atgataaagc
     8221 gaaagctgag ctggatgccg aagataaaaa tattgcgacc ttaaacagcc gcattgcatc
     8281 gacagagaag gcgctccccg gtgcaagggc tgctgttcag gaagccgata aaaaggtaaa
     8341 agaggcagag gcaaataaag atgattttgt gacttataac ccgcctcatg aatatggctc
     8401 cgggtggcag gatcaggttc gctatcttga taaggatatt cagaatcaga atgagaaatt
     8461 aaaagcggct caggcatctt taaacgcaat gaatgaatcc ttatccagag ataaggctgc
     8521 acttaccggg gcgatggaga gccggaaaca aaaggagaaa aaagcgaagg atgcagaaaa
     8581 taagttaaat gaggaaaaga acaagcctcg caaggggact aaagactacg gccatgatta
     8641 tcatccagta cctaaaacag aagacataaa gggacttgga gagttaaagc gaggtgatcc
     8701 taaaacacct aaacaaggtg gtggtggtaa gcgggcccga tggtatggcg ataaaaaacg
     8761 taaaatttat gaatgggatt cccagcacgg tgagcttgaa gggtatcgtg ccagtgatgg
     8821 cgaacaccta ggcgcatttg atcccaaaac gggtaagcag gttaaagggc cagatccaaa
     8881 acggaacatt aaaaaatatc tttgagaggt aaatatgggg cttaaattac gtttgacatg
     8941 gtttgataag aaaactgaag agtttaaagg ggaagagtat tctaaagact ttggtgacga
     9001 tggttctgtc attgaaagct tgggaatgcc tttaaaggat aatattaata atggtgagtt
     9061 tgatttgaag aaagaatggg ttcctttact acagccattt tttaaaaatc aaataaaacc
     9121 tgatgtggat aattgttata tagcttttga ttatcgggac ggtaactggt aacaaaaaat
     9181 tatcaaggat gatttgaaat actgacttcc ggtgttcagg gatgaatgcc ggagtcttta
     9241 aatacaggga aagtatatga aaaaggtaaa gactattttt ctttttatat tgattgttgc
     9301 tggctttctt ctggccgcat gtcaggcaaa ttatatccgg gatgttcagg gcggaacggt
     9361 ggcaccatcg tcctcctctg aactgacggg gatcgcggtt cagtagaaaa gatcaaagga
     9421 tcttcttgag atcctttttt tctgcgcgta atcttttgcc ctgtaaacga aaaaaccacc
     9481 tggggaggtg gtttgatcga aggttaagtc agttggggaa ctgcttaacc gtggtaactg
     9541 gctttcgcag agcacagcaa ccaaatctgt ccttccagtg tagccggact ttggcgcaca
     9601 cttcaagagc aaccgcgtgt ttagctaaac aaatcctctg cgaactccca gttaccaatg
     9661 gctgctgcca gtggcgtttt gcgtgctttc ccgggttgga ctcaagtgaa cagttaccgg
     9721 ataaggcgca gcagtcgggc tgaacgggga gttcttgctt acagcccagc ttggagcgaa
     9781 cgacctacac cgagccgaga taccagtgtg tgagctatga gaaagcgcca cacttcccgc
     9841 aagggagaac ggcggacagg tatccggtaa acggcagggt cggaacagga gagcgcaaga
     9901 gggagcgacc taccggaaac ggtggggatc tttaagtcct gtcgggtttc gcccgtactg
     9961 tcagattcat ggttgagcct cacggctccc acagatgcac cgaaaaagcg tctgtttatg
    10021 tgaactctgg caggagggcg gagcctatgg aaaaacgcca
//
