LOCUS       CP018672                9294 bp    DNA     circular BCT 19-DEC-2016
DEFINITION  Klebsiella pneumoniae strain CAV1217 plasmid pCAV1217-9294, complete
            sequence.
ACCESSION   CP018672
VERSION     CP018672.1
DBLINK      BioProject: PRJNA246471
            BioSample: SAMN03024585
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 9294)
  AUTHORS   Mathers,A.J., Stoesser,N., Chai,W., Carroll,J., Barry,K.,
            Cherunvanky,A., Sebra,R., Kasarskis,A., Peto,T.E., Walker,A.S.,
            Sifri,C.D., Crook,D.W. and Sheppard,A.E.
  TITLE     Chromosomal Integration of the Klebsiella pneumoniae carbapenemase
            gene (blaKPC) in Klebsiella Species: Elusive but not Rare
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9294)
  AUTHORS   Mathers,A.J., Stoesser,N., Chai,W., Carroll,J., Barry,K.,
            Cherunvanky,A., Sebra,R., Kasarskis,A., Peto,T.E., Walker,A.S.,
            Sifri,C.D., Crook,D.W. and Sheppard,A.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-2016) Nuffield Department of Medicine, University
            of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. unspecified
            Genome Coverage                   :: 200x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 12/13/2016 10:11:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            Annotation Method :: Best-placed reference protein set; GeneMarkS+
            Annotation Software revision      :: 4.0
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes (total)                     :: 5,746
            CDS (total)                       :: 5,625
            Genes (coding)                    :: 5,433
            CDS (coding)                      :: 5,433
            Genes (RNA)                       :: 121
            rRNAs                             :: 9, 7, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 7, 8 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 11
            Pseudo Genes (total)              :: 192
            Pseudo Genes (ambiguous residues) :: 0 of 192
            Pseudo Genes (frameshifted)       :: 109 of 192
            Pseudo Genes (incomplete)         :: 68 of 192
            Pseudo Genes (internal stop)      :: 40 of 192
            Pseudo Genes (multiple problems)  :: 23 of 192
            ##Genome-Annotation-Data-END##
            Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..9294
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="CAV1217"
                     /isolation_source="Urine"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="pCAV1217-9294"
                     /geo_loc_name="USA:Virginia"
                     /lat_lon="38.14 N 78.45 W"
                     /collection_date="Aug-2010"
                     /collected_by="Clinical Microbiology University of Virginia
                     Health System"
     gene            join(8885..9294,1..10)
                     /locus_tag="AGE86_00005"
     CDS             join(8885..9294,1..10)
                     /locus_tag="AGE86_00005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="entry exclusion protein 2"
                     /protein_id="APP23866.1"
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
                     /name="entry exclusion protein 2"
     gene            316..579
                     /locus_tag="AGE86_00010"
     CDS             316..579
                     /locus_tag="AGE86_00010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid stabilization protein"
                     /protein_id="APP23854.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="plasmid stabilization protein"
     gene            569..868
                     /locus_tag="AGE86_00015"
     CDS             569..868
                     /locus_tag="AGE86_00015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="addiction module toxin RelE"
                     /protein_id="APP23855.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="addiction module toxin RelE"
     gene            complement(930..1307)
                     /locus_tag="AGE86_00020"
     CDS             complement(930..1307)
                     /locus_tag="AGE86_00020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="entry exclusion protein 1"
                     /protein_id="APP23856.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="entry exclusion protein 1"
     gene            1376..1555
                     /locus_tag="AGE86_00025"
     CDS             1376..1555
                     /locus_tag="AGE86_00025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase"
                     /protein_id="APP23857.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="RNA polymerase"
     gene            complement(1583..2113)
                     /locus_tag="AGE86_00030"
     CDS             complement(1583..2113)
                     /locus_tag="AGE86_00030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="APP23858.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(2120..2851)
                     /locus_tag="AGE86_00035"
     CDS             complement(2120..2851)
                     /locus_tag="AGE86_00035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="APP23859.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="hypothetical protein"
     gene            complement(2851..4815)
                     /locus_tag="AGE86_00040"
     CDS             complement(2851..4815)
                     /locus_tag="AGE86_00040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mobilization protein A"
                     /protein_id="APP23860.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="Mobilization protein A"
     gene            complement(4828..5145)
                     /locus_tag="AGE86_00045"
     CDS             complement(4828..5145)
                     /locus_tag="AGE86_00045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="APP23861.1"
                     /translation="MLDAPGEAAKLLLILRVVSRSLWRTLTGAGTPEKTALGCRLFLSH
                     AGACSLFLRGCAFSAWGGKRLASVVKAERNHHGRDRRRHALGHVRGLCSGGCTSRRQTI
                     V"
                     /name="hypothetical protein"
     gene            complement(6296..6445)
                     /locus_tag="AGE86_00050"
     CDS             complement(6296..6445)
                     /locus_tag="AGE86_00050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lysis protein"
                     /protein_id="APP23862.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="lysis protein"
     gene            complement(6530..6787)
                     /locus_tag="AGE86_00055"
     CDS             complement(6530..6787)
                     /locus_tag="AGE86_00055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="APP23863.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin"
     gene            complement(6797..8482)
                     /locus_tag="AGE86_00060"
     CDS             complement(6797..8482)
                     /locus_tag="AGE86_00060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin"
                     /protein_id="APP23864.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="cloacin"
     gene            8604..8831
                     /locus_tag="AGE86_00065"
     CDS             8604..8831
                     /locus_tag="AGE86_00065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001328716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="APP23865.1"
                     /translation="MRFCENDQKNSHSHHAQSPPDATKTSTNGAVLRPQYVLLKSLYEI
                     PESPLRDRKRNGGSGSGCSVTEHGQKLMIR"
                     /name="hypothetical protein"
     BGC             1797..9294
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          5615..6193
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(2124..2851)
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.32e-150"
ORIGIN
        1 cagacagtaa gtggatttac cataacgcgt cattacgcgc accgctcaga cgggctcagg
       61 gcgtttccgg cggctacggg ataaaacagg caacaacccc cccggaaaac tgccggaaac
      121 gcgcccgata aattttatcc taatgcatgc ctatgcacgc aactgcatgg catatgtttt
      181 gacgtaaaat ggatgccgta agcccttttt taccgacttt ctgcttcatc agcctgactg
      241 acacgaccat attctttcag accgccccct gctaaacttc cttcatattg ccgcattaac
      301 ccgggaggct ccgcaatgag caacactaca cactacgaaa acgccaactt tcttcgggaa
      361 ctggctgaaa gcctgccccg catactgccg gaaggtggcc cggacaaagc tgcgctgttg
      421 cagcgactgg ctaacgaaga actggcccag gcagagtatg aagatcaggt tcgcgccaaa
      481 gtgaccgccg cccgtgctga cacgcgtccg ggtatgacca cggaacaact ccgccagcgc
      541 ctgcatggcc gttatcagga actgcgcgat gccgtatgac gtggaatgga agcagggagc
      601 catcgaggat gtaacgacgc tgtttgacta tatcgcggaa aattcatccc tgtgggatgc
      661 gcagaacgtt accgaccggg ttctcgctgc ggcggacaaa ctggccgact tcccgcgact
      721 ctatgaagtg gactcacgct atggcgagga cgttcgccgg atcagtctga tgggacagca
      781 tgtcctctat gatgttgatg accagaccag aaaagtccgg gttctggccg tggtcggcca
      841 gcgccagaat ccccatattg ttctctaata accggtgacg gggacgcaat tcattgcgtg
      901 gccgtcgccg gttggacaag cacagcgcgt cagcgttttc cccacggcca ccaccggcgc
      961 ggtgttccgg ccggggtctc tgctgtctcc ggtttgtgtt ccagcagtct catggactgc
     1021 atttcctgcc gtagcccggc cacctcctcc ctgagtgctt ttatctccgc gatcaacgcg
     1081 tcggaggcca ttttttcagt ctcacccgac agtctcaact cgtcccgctc gtgagtctca
     1141 tcctgtctta actcaccgta cacccggata agctcgctgg tatccaccac ccggccgcca
     1201 tcagcttccg tacggtatga tacgcggcct ttcgccatat cccgatacag ggaacttcgg
     1261 gctttacccg tcagttccgt cgcctgtctc accgtcaccc acgccattgt ctcaccccgc
     1321 tatttttgag acagtatacc tgacaggcgc acaccatgcc cggaaggaaa gaatcatgac
     1381 aaaacaggaa aaaacagccc tcaatatggc taaatttatt aaggagcagt cgctgctatt
     1441 gctcgataaa ctgaatgagc tggatatgga taccccggcc gacatgtgcg agcggctaca
     1501 cgaggatgcg gaaacactct ggcaggtgat gcgggataag ctcggggagg aataacagca
     1561 ccggcatggc cggtgctggc atttattttt tgccgaacgg ccaccaccgg cgggcaggtt
     1621 tgtcctccgg cagttcaggt accggcacgt taaaatagcg gctgttatat tcccgcatca
     1681 gctccgcttt cagcttctcg ttcaccgcgc tttccccgtg ccgctcactc accacgtcaa
     1741 tcatcgcgtt aatctgctcc ggtgagcact tcccggcatc aaccacctgc acaccgttct
     1801 cgatggcgaa ccgctccacc ttgcgataga ggtaatcaca cagcttcatt cctgtgggtt
     1861 tgttccgttc ccattgcgga tttttaccag tgaaaaagta cgtggctttt tcgtcgctgt
     1921 tgagccgctc gtcatacatc ccgatggatt tcatcatcgc cagatgctgg gcccggtcga
     1981 caaaacagaa aacatacgcc ccggtctgcc aggcgagcac caccatatct tccagatgct
     2041 cgctggtcgg catgatgcag cgctcgccgt tccggtcctc cgcgtcttca ataaatacca
     2101 tgtacagcgc cataatccct cactccgttg tcataaattt aaagcacgca aacaaccgtt
     2161 cacgatccag ctctgccgtt ttgcgggcct cgccggtctg tgggttcacg atttcatcca
     2221 ccgacaggat tgcccgctgc accctgacct gcgtcgcccg gtccgggcag atgtaccaga
     2281 tttcatcgat gccgttagct ttgcggttga acagataccc ggacaccact tcctgatacc
     2341 ggcgacggct cttgacggtg cgctccacct caaacgccac cgttttaccg tccagctccg
     2401 ccagggcgtc cggcactttc atgcctttaa gactcagacg gtgcagaatg cgccagccgg
     2461 tggcccctct ggcttccata tcaaggcgca gggattgcac ggccagccgg tgcggcagat
     2521 gtgctgccga cacccttgac ggctgaaacg gaataacatc cgccagcggt tcgtcctcgt
     2581 cgaacgagaa cgccacgcca tgcggcgtca gcccccacac gctgacctga cggccgtcca
     2641 ccggatattt ggtccggacc agcagccctt tcgccaccag gctgtcgagg aagcggtaga
     2701 ccggctgcac cgccgcaatc cccagccgcc gcgcaaccag ctccgccgtg gaacacagct
     2761 cttcccgcaa ccagcgcagg gtcagccggg ttttctccgc gttccgcgcc tgtcgtttcg
     2821 cgtggctgac gttgtacagc tccagcgcca tcagtaaatc cccgcaaaat catcatccgc
     2881 tttcggcccg ccgccgtcgg ccgggggccg gaactccgcc aggggatcgg ttttcgccag
     2941 caccgggaaa cgctgcaacg ggatttcccg gcgctcaacc cgcagcggac tgctgaacgc
     3001 catccgggcc acacccagcc cggtcatgac cgcgaacccg tccggcaggt gttgcagggt
     3061 gttcacgtca aacagcggcc gcgcctcctt ctggatgaag ctgtccccgc tgatatgctc
     3121 cacgttcccc gcctcccggc tggcacggcg gcgctccacg tccaccctga tttccccggt
     3181 ctgccccgcc gcccactgcg cggactccag gctggccgcc cggtaaaacc agcggatcgg
     3241 cgtgttatcc agtaccgtgg ttttcacaaa ttcagcgggc agatcctgcc cgcactgccc
     3301 gaaatcgccc agcgactggt gcgcgagcaa cagattgcag tcccggctgc gcagcgtccc
     3361 cagtgcgttc agtacatact tcgacagcag atatttaatt tcatcgagca tcacgctgac
     3421 gtgtggccac tcccggaact cgtcccgcgc aatgatgatt tgcgcgcagc gggcaaacag
     3481 cattttttgc acacggatca ccgcctcgtc gtccatcgag ccgataacgt acaggcagcc
     3541 gccgccgttg ataatccccg ccacatcgat gccactgtcc gtctgcagga cgctcaggtc
     3601 agcgacgttt tccagcctag tgatcaaccc cttcacgtcc tttttcaggg cctccggcag
     3661 cgcgtacgcc gccgccagca cctgctgaat gtttgccccc tgcggaaact gctccgcaat
     3721 cagcttcgcc gctttctgct cgctgatgcg gtagtggtcc gccacgtcgc cggtctcgcc
     3781 caggttaagc ccggcaatca gcaggttttt cagcgcgtac tggtcgagat cgcggaacag
     3841 attcagctgc gccggtttcc ccggccgcag atccagcagg gtgaagtccg gacagtgcgc
     3901 ccggaagacg tgcggcgccc atgcgtcccc tttggggtcg aagtacacca ccgcgtcccc
     3961 gaaatcgcgt acgcagcgaa tgagcgcgtt ggtggccatc acgctcttgc cgctcccggg
     4021 caggccgagg atctgaatgt tggtcttgcg ccaggtatca cgcggaacca gcaccggctt
     4081 gccctgctca tccttaccca gaaacaccgc ctgctcctgc cgggcctgct ccgaggaaaa
     4141 atcggccagc gcattaaccg gtaccggctc cccgaaatgc aggtggcgca cgtcggtcat
     4201 ctctcctgtc cgctggctgc tgcgccggct ctcctgattc agtttcgcgt tcaccgcctc
     4261 gtcagcagcc gcaaaatgac cgtcaagcag caggaacgcc agcagccgcg ccaacacaat
     4321 cccgacagcc agcccgcccg cgcaccaggc aatcccgaac aggttagccg gctgcagcag
     4381 gtaataatct gcgtttgcgt agaggtccgg acgcaggacg gtttctcccc agctctcgat
     4441 aaacacggcg acaaccagcc cccccagaag ggccagaccg gccgcgccgg tcagccagta
     4501 cgcgtagttc cagacatgtc gacgtgccct gaccatccgc ccgggcgaat ccagcgaggc
     4561 cagcaccgaa aatggcgctg gccgtttatt atcgcgctta tagcgatcgg catactcccg
     4621 tcgctcctta tgactcagcc ccacaaaacg catccgtccg gcccaaagtt cagccagacc
     4681 gaaaaacagg ccgataacta ggaaagcccc ggccagaccg taatactcct ggtacagcca
     4741 gctgacccac ggataaatct gccgggccag ctccggaatg tgccacttcc aggcaagcga
     4801 atccgtatta aacatgttct ctctccttca gacgatggtt tgccggcgtg atgtgcagcc
     4861 cccgctgcac aagccgcgga catgccccaa ggcatggcgg cggcggtcac gtccgtggtg
     4921 attgcgttca gctttcacca cggaggccag cctctttccg ccccatgcgg aaaaggcgca
     4981 gccccggagg aacaacgagc acgccccagc gtgtgagagg aaaaggcggc accccagtgc
     5041 ggtcttttcc ggtgttccgg cccccgtcag agttcgccat agcgagcggc tgaccacccg
     5101 caaaatcagg agcagctttg ctgcttcgcc aggtgcgtcc agcaccgtgg atttttgtgg
     5161 gtggtcaggc gtgagcctga cgggggccgg gtgaatttct ggcgtggccg gcgtccagcc
     5221 ggacggagcc agaaagaggg ggagagaccg tgcgtcggtg gcgtccagcc agcgtaagca
     5281 ggggatatcc ccctgaggtc agccacgccc tcgcggggat gacctgtatt tctccgtaag
     5341 gagaaaaaag caacagagat aggttaacgt aaaatgttca gcgaaaaacc gatatgattc
     5401 acctatcctg gtaatttatt atcagggaat ataaagactt aatcagggga caatatgcca
     5461 catcagcgcg tccggtgtcc gtcttgtagg tgccggggaa attgcgcctc ctcgctcact
     5521 cggtcgctac gctccggccg tgagactgcg gcgggcgctg cggacacatg caaagttacc
     5581 cacagattcc gtgaataagc aggggactaa catgtgaggc aaaacggcaa ggccacgcag
     5641 gtggcgtttt tccataggct ccgccctcct gactgagttc acataaacag acgctttttc
     5701 ggtgcatctg tgggagccgg tggctcaacc atgaatcagt caggagtggc gaaacccgac
     5761 aggacttaaa gatcatcacc gtttccgatg aatcgctccc tcttgcgctc tcctgttcca
     5821 accctgccgt ttcccggata cctgttccgc ctttctccct tgcgggaagt gtggcgcttt
     5881 ctcatagctc acactctggt atctcggctc ggtgtaggtc gttcgctcca agctgggctg
     5941 taagcaagaa ccccccgttc agcccgactg ctgcgcctta tccggtaact gttcacttga
     6001 gtccaacccg gaaaagcacg caaaacgcca ctggcagcag ccattggtaa ctgggagttc
     6061 gcagaggatt tgtttagcta aacacgcggt tgctcttgaa gtgtgcgcca aagtccggct
     6121 acactggaag gacagatttg gttgctgtgc tctgcgaaag ccagttacca cggttaagca
     6181 gttccccaac tgacttaacc ttcgatcaaa ccacctcccc aggtggtttt ttcgtttaca
     6241 gggcaaaaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctact
     6301 gaaccgcgat ccccgtcagt tcagaggagg acgatggtgc caccgttcca ccctgaacat
     6361 cccggatata gtttgcctga catgcgacca gaagaaagcc tgaaaaaatc aatataaaaa
     6421 gaaaaacaac ctttaccttt ttcatatacc ttccctgtat ttaaaaaccc cggtattcat
     6481 ccctgaacac cggaagtctg tatttcaaat catccttgat aacttttgct taccagttac
     6541 catcccggta aacaaaggat acaaagtaat caaatttact aatatcgatt acatttttaa
     6601 agtgtggctg taatatcgaa acccatgatt tttcaacatc aaaccaacca ttattaatat
     6661 tatcctttaa aggcatcccc agactttcaa tgacagaacc atcatcaccg aagtcttttg
     6721 agtattcacc acctttaaac tcttcggttt tcttatcaaa ccaatgaata tgtaatttaa
     6781 gccccatatt tacctcttaa agatattttt taatgtttcg ttttggatcc ggccctttaa
     6841 cctgcttacc cgtttttgga tcgaatgccc cgaggtgttc gccatcactg gcgcggtacc
     6901 cttcaagctc accgtgctgg gaatcccatt cataaatttt acgcttttta tcaccatacc
     6961 atcgggcccg cttaccacca ccaccttgtt taggggtttt aggtttaccc tctttcaact
     7021 ctcccaaccc cttaatatct tcagtcttgg gatcaggaaa ataatcatgg ccgtaatctt
     7081 tagttccctt acgaggtttt ttcttttcct catttaattt attttctgca tccttcgctt
     7141 ttttctcctt ttgtttccgg ctctccatcg ccccggaaag cgcagcctta tccctggata
     7201 aggattcatt catttcgttt aaagatgtct gggcagcttt taatttctca ttctgattct
     7261 gaatatcctt atcaagatag cgaacctgat cctgccaccc ggagccatat tcatgaggcg
     7321 ggttataagt cacaaaatca tctttatttg cctctgcctc ttttaccttt ttatcggctt
     7381 cctgaacagc agcccttgca ccggggatcg ccttctctgt cgatgcaatg cgactgttta
     7441 aggtcgcaat atttttatct tcagcatcca gctcagcttt cgctttatca tactctcttt
     7501 tcagcccctc ttccgggtga gcagcgtccc atgcctgctg gcgacgcttt tcttcctcca
     7561 gacgctgttt tacctgtgcc ggagtaagaa catccgtcac cgacacatag accggtttct
     7621 gtccgctctc tttcgggaaa cgaataacgg cttcacggga gttaccaccg gccgtaaaac
     7681 cagccggacg tgaatcacct ttttcagcaa taatgccttt tggcggggct ttcgcggccg
     7741 gaacaccttt aggtacgctc acctgcagag acgggagacc cggaatcgac acactgaata
     7801 cccccggacg ttttgtcggt ttcgcatcca ccacaggaac actcattggc cggccggtga
     7861 caaccgcaat atgctgccgc tcgtccttca caatatccgc cacacgttta gtgacgctga
     7921 ccgtcgcctg gtccagcggc agggagctga ccggcgtctc cgttaccgtg tctgccggca
     7981 atgacgtcac gatttttgac atcattttcg gatcatcttt tgctatctca gaaggcagca
     8041 ctccgtaaat cgcaatcccc cacagaccaa acttaaacgg acctttcagg gcagccagca
     8101 catcagcaac agcggccgac aacgcatcgc cggaaacgga taaagccagt ccttcagccc
     8161 ccggagtggc caaggcaggc agaccgaagg ccatcgcggt ggccgaagac tgtccgccac
     8221 cagagctccc gctatgattg ccgctgttac cgccattacc accgggttta ctcccgccgt
     8281 taccaaactc ccccgggtta tagttatgaa tatccccgtt aggtgtatgc gtcgtacccc
     8341 agcccggccc gctgtttgga tccgtaccac cacctgatga agggccacct ttacctgatg
     8401 taccgttcac attcccactg gcctgaccac cattgtgtcc cagacctgaa ttacccggac
     8461 ctcgtccgtc tccgccactc atatactttt cctctttgac ttttaaaaca ataaactaaa
     8521 ataaaatact gtacatataa ccactggttt tatatacagt ataaaaatta cgctgccttg
     8581 tttttcatgt caagtctgta aatttgcgtt tttgtgaaaa tgatcaaaaa aacagccact
     8641 cacaccatgc gcaatcccct ccagatgcaa caaaaaccag cacaaacggc gccgttctcc
     8701 ggcctcagta tgttttactg aaatcattat atgagatacc agaaagcccc ctccgggaca
     8761 ggaaaagaaa cggggggtct ggttcgggtt gttcggtcac tgaacacggt cagaaactga
     8821 tgataagata gcctgcggat atataactca atgagaaaaa agaattaaag gtaaggagac
     8881 gctcatgaga cgttccggca gcaaactgtg tcttatcgcc atgataacag cgacagcaac
     8941 tctcactgcc tgtgctccaa agggcagcgt ggaacagcat acccggcatt acgtatatgc
     9001 ttcagatgac ggttttgatc ccaatttttc cacccagaaa gctgacacaa cacgaatgat
     9061 ggtgcctttt ttccggcagt tctgggatat gggcgcaaag gataaagcga ccggaaaatc
     9121 acggagtgat gtgcagcaac gcattcagca gtttcacagt caggaatttt taaactcact
     9181 ccaaggcaca acacaatttg cgggtaccga ttaccgcagc aaagacctca caccgaaaaa
     9241 atcaaggcta ctggctgaca ccatttcagc tgtttatctc gatggctatg aagg
//
