LOCUS       CP011628               16069 bp    DNA     circular BCT 09-JUN-2015
DEFINITION  Klebsiella oxytoca strain CAV1374 plasmid pCAV1374-16, complete
            sequence.
ACCESSION   CP011628
VERSION     CP011628.1
DBLINK      BioProject: PRJNA246471
            BioSample: SAMN03733738
KEYWORDS    .
SOURCE      Klebsiella oxytoca
  ORGANISM  Klebsiella oxytoca
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 16069)
  AUTHORS   Sheppard,A.E., Stoesser,N., Wilson,D., Sebra,R., Kasarskis,A.,
            Anson,L., Giess,A., Pankhurst,L., Vaughan,A., Grim,C.J., Cox,H.,
            Yeh,A., Sifri,C.D., Walker,S., Peto,T.E., Crook,D.W. and
            Mathers,A.J.
  TITLE     Rapid spread of a carbapenem resistance gene driven by multiple
            levels of genetic mobility
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 16069)
  AUTHORS   Sheppard,A.E., Stoesser,N., Wilson,D., Sebra,R., Kasarskis,A.,
            Anson,L., Giess,A., Pankhurst,L., Vaughan,A., Grim,C.J., Cox,H.,
            Yeh,A., Sifri,C.D., Walker,S., Peto,T.E., Crook,D.W. and
            Mathers,A.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-JUN-2015) University of Oxford, John Radcliffe
            Hospital, Oxford OX39DU, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method              :: HGAP3 v. 2.2.0
            Genome Coverage              :: 57X
            Sequencing Technology        :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider          :: NCBI
            Annotation Date              :: 06/03/2015 10:35:07
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            Annotation Method :: Best-placed reference protein set; GeneMarkS+
            Annotation Software revision :: 2.10
            Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region
            Genes                        :: 6,915
            CDS                          :: 6,622
            Pseudo Genes                 :: 175
            rRNAs                        :: 25 (5S, 16S, 23S)
            tRNAs                        :: 86
            ncRNA                        :: 7
            Frameshifted Genes           :: 42
            ##Genome-Annotation-Data-END##
            Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..16069
                     /organism="Klebsiella oxytoca"
                     /mol_type="genomic DNA"
                     /strain="CAV1374"
                     /isolation_source="Perirectal"
                     /host="Homo sapiens"
                     /db_xref="taxon:571"
                     /plasmid="pCAV1374-16"
                     /geo_loc_name="USA:Virginia"
                     /lat_lon="38.14 N 78.45 W"
                     /collection_date="2010-08"
                     /collected_by="Clinical Microbiology University of Virginia
                     Health System"
     gene            complement(join(15351..16069,1..154))
                     /locus_tag="AB185_00115"
     CDS             complement(join(15351..16069,1..154))
                     /locus_tag="AB185_00115"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_008168811.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mucin"
                     /protein_id="AKL32386.1"
                     /translation="MAREGITFEQVAAAADALVGEGQQPTIRAIRERLGTGSPNTVHKH
                     LTAWREARPVAAAAAPELPQALTAAIAAEIERAAAQARAEIEGRLVQAQGEAVELAAAG
                     EVIEAERDALAEQVAELTRERDTLAGKAEQQAADLADQAQRIEREQQAAESARVELATA
                     RLKIEAQAERQTEQAAEIERLRAALADAQQGRTAAEQQAAVLAAKLEACAERVARAEAR
                     VEQIEQQAAKAAQANEEARAAAAQEARQVQAERDEARKVAAEAREQAARLAGQLEALTT
                     KERKTDERP"
                     /name="mucin"
     gene            712..1143
                     /locus_tag="AB185_00120"
     CDS             712..1143
                     /locus_tag="AB185_00120"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="AKL32387.1"
                     /translation="MGEGGEPGRLVEATGGGLSFLEDLVAVAYGCGRFLAWAVVPRPGA
                     PSGPLWGPRYAGERVARGVQRSETPGGCRVGARSAGGGPLAARRSRQGACPLRGGAVFG
                     GRCVFHSERPSNYRLKIKVKTKGITYRFRGGLIRHDQGV"
                     /name="hypothetical protein"
     gene            complement(1386..2297)
                     /locus_tag="AB185_00125"
     CDS             complement(1386..2297)
                     /locus_tag="AB185_00125"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_011053000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication protein"
                     /protein_id="AKL32402.1"
                     /translation="MIPPKPKTTPTTPREARLVKKAAEIASERPDDDDRGYMHSIMCQV
                     GLPRSKVDATSFERHSGGAALLVEAGKLWDGKQFVQQPIPYGPMPRLMLAWMNTYAVRF
                     NTAEIPVGDSASEFLRMLGKTPNGGRNSVYTTFRKQVQALSACRITLGFNANGRAHTYE
                     GKPIKHFEAWIASTEEQRPLWPGSVTFSDDYYQTLKSHAVPLDLRAFMELKGSALAMDV
                     YTWLAQRLHRIEGRPVVLHWASLREQFGQEYQGKDPDKDFKKKFLHALRAVLAVYPQAR
                     VKQVTGGVMLMASPPPIPFKGS"
                     /name="replication protein"
     gene            complement(2731..3054)
                     /locus_tag="AB185_00130"
     CDS             complement(2731..3054)
                     /locus_tag="AB185_00130"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="AKL32388.1"
                     /translation="MEVIEMASANILAGFKPETVELLHSFAAYVDEIDGTEATPTELAL
                     SLIEADGRPGEFQAEQIVGAVLAEHRRFQRWLRDRRTVLMQDGWQAWAVRNARAGRTAA
                     FAV"
                     /name="hypothetical protein"
     gene            complement(3139..3420)
                     /locus_tag="AB185_00135"
     CDS             complement(3139..3420)
                     /locus_tag="AB185_00135"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_011630659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="AKL32389.1"
                     /translation="MNKPTGLAAFTRKGAASAQQTATDQEPGAEQSAETRQRGRGKGDV
                     VALTVRLPRAEWERVHQLAVSEGVSIQSLAVDGLSKVFAEKGLPTLSV"
                     /name="hypothetical protein"
     gene            complement(3417..4034)
                     /locus_tag="AB185_00140"
     CDS             complement(3417..4034)
                     /locus_tag="AB185_00140"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_011630658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="AKL32390.1"
                     /translation="MKKIAFLAQKGGSGKTTLAVHTAVAATEAGESVVVIDTDPQKSAT
                     VWGDARSQEVPIVATAAASELGRVLEAADQERMTLAIVDTAPHAAPDATRIVRAVDLVA
                     IPVRPTAFDIAAAGSAVDIVKAAGVRAVFVLSACPFRSPEIAETRTVLAEYGLPIAPVE
                     IIDRRAFARAVATGRAVTEFESDGKAATEIRALWAWLKEQMQ"
                     /name="hypothetical protein"
     gene            complement(4151..5155)
                     /locus_tag="AB185_00145"
     CDS             complement(4151..5155)
                     /locus_tag="AB185_00145"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_017161560.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease Cfr9I"
                     /protein_id="AKL32391.1"
                     /translation="MTTPNKINFPPPKLQIDFAFALKRFRAVYLQSALLETVRDMDIAE
                     LDKQLAEYVPPADLATLAQYGLRAELLFAVPAVLEANPYLLGYYRLLMGYSQKEFYGRD
                     KGFGVGYFKSMEEKGKTSKTAAADLPDLCVAFCATASALLAGVGPLRVSRELLDDLTLL
                     TVGPQLRGGANNQRGTDGIVQVFEIIREIVAHAAAEVRESAIEVNSATGRPFLIEFAPD
                     PDIIIREEMEHQHYRNVVAIEVKSGTDVSNIHNRIGEAEKSHQKARQRGFTECWTVVNV
                     GRLDMVKARSESPSTDRFYSLAALSLRAGDEYDDFRRRVLSLTAIPSAPLTKT"
                     /name="restriction endonuclease Cfr9I"
     gene            complement(5152..6054)
                     /locus_tag="AB185_00150"
     CDS             complement(5152..6054)
                     /locus_tag="AB185_00150"
                     /inference="EXISTENCE: similar to AA
                     sequence:SwissProt:P30774.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="modification methylase"
                     /protein_id="AKL32392.1"
                     /translation="MPKAKTAAPSGVERIQRPEPLTLRGSTLFEGDALTVLRRLPSGSV
                     RCVVTSPPYWGLRDYGIEEQIGLESTMPQFLHRLVAIFAEVRRVLTDDGTLWLNIGDGY
                     TSGNRGYRAPDKKNPARAMDVRPDTPEGLKPKDLIGIPWRLAFALQDDGWYLRSDIVWN
                     KPNAMPESVKDRPARSHEFLFMLTKSEKYYYDWQAVREPADGGGLRNRRSVWHVNTRPF
                     AGAHFATFPPDLIRPCIQASTEPGDYVLDPFFGSGTVGLVCQDENRQYVGIELNPEYVA
                     LAADRLQGQDSNVIRIAAA"
                     /name="modification methylase"
     gene            complement(6069..6641)
                     /locus_tag="AB185_00155"
     CDS             complement(6069..6641)
                     /locus_tag="AB185_00155"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_013641240.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase"
                     /protein_id="AKL32393.1"
                     /translation="MNQRIGYARVSTDDQNLDLQRDALRQAGCSTIYEEAASGKSAARP
                     ELEQCRKALRAGDTLVVWRLDRLGRSLPDLVQIVADLEQRGVQFESLTEKIETGSAAGK
                     LQFHVFAALAEFERGLIRERTRAGLEAARARGRSGGRKPKLDAKQIRHIKALLRDPNTC
                     VAELARDYGVSRTTIYKHCGVVQPRHD"
                     /name="recombinase"
     gene            complement(6986..7999)
                     /locus_tag="AB185_00160"
     CDS             complement(6986..7999)
                     /locus_tag="AB185_00160"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_012077405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="integrase"
                     /protein_id="AKL32394.1"
                     /translation="MKTATAPLPPLRSVKVLDQLRERIRYLHYSLRTEQAYVHWVRAFI
                     RFHGVRHPATLGSSEVEAFLSWLANERKVSVSTHRQALAALLFFYGKVLCTDLPWLQEI
                     GRPRPSRRLPVVLTPDEVVRILGFLEGEHRLFAQLLYGTGMRISEGLQLRVKDLDFDHG
                     TIIVREGKGSKDRALMLPESLAPSLREQLSRARAWWLKDQAEGRSGVALPDALERKYPR
                     AGHSWPWFWVFAQHTHSTDPRSGVVRRHHMYDQTFQRAFKRAVEQAGITKPATPHTLRH
                     SFATALLRSGYDIRTVQDLLGHSDVSTTMIYTHVLKVGGAGVRSPLDALPPLTSER"
                     /name="integrase"
     gene            8157..8630
                     /locus_tag="AB185_00165"
     CDS             8157..8630
                     /locus_tag="AB185_00165"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_001389366.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrofolate reductase"
                     /protein_id="AKL32403.1"
                     /translation="MKISLISAVSENGVIGSGPDIPWSAKGEQLIFKALTYNQWLLVGR
                     KTFDSMGVLPNRKYAVVSKNGISGSNENVLVFPSIENALQELSKITDHVYISGGGQIYE
                     SLIEKADIIHLSTIHVEVEGDIKFPILPEGFNLVFEQFFVSNINYTYQIWKKG"
                     /name="dihydrofolate reductase"
     gene            8823..10043
                     /locus_tag="AB185_00170"
     CDS             8823..10043
                     /locus_tag="AB185_00170"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_019854381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="AKL32395.1"
                     /translation="MTWRTTRTLLQPQNLDFNEFEILTSVIEGARIVGIGEGAHFVAEF
                     SLARASLIRYLVERHDFNAIGLECGAIQASRLSEWLNSTAGAHELERFSDTLTFSVYGS
                     VLIWLKSYLRESGRKLQLVGIDLPNTLNPRDDLAQLAEIIQLIDHLMKPHVDMLTHLLA
                     SIDGQSAVISSAKWGELETARQEKAISGVTRLKLRLASLAPVLKKHVNSDLFRKASDRI
                     ESIEYTLETLRIMKTFFDGTSLEGDTSVRDSYMAGVVDGMVRANPDVKIILLAHNNHLQ
                     KTPVSFSGELTAVPMGQHLAERVNYRAIAFTHLGPTVPEMHFPSPDSPLGFSVVTTPAD
                     AIREDSMEQYVIDACGTENSCLTLTDAPMEAKRMRSQSASVKTKLSEAFDAIVCVPSAG
                     KDSLVAL"
                     /name="hypothetical protein"
     gene            10128..10919
                     /locus_tag="AB185_00175"
     CDS             10128..10919
                     /locus_tag="AB185_00175"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_001261740.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylyltransferase"
                     /protein_id="AKL32396.1"
                     /translation="MRVAVTIEISNQLSEVLSVIERHLESTLLAVHLYGSAVDGGLKPY
                     SDIDLLVTVAVKLDETTRRALLNDLMEASAFPGESETLRAIEVTLVVHDDIIPWRYPAK
                     RELQFGEWQRNDILAGIFEPAMIDIDLAILLTKAREHSVALVGPAAEEFFDPVPEQDLF
                     EALRETLKLWNSQPDWAGDERNVVLTLSRIWYSAITGKIAPKDVAADWAIKRLPAQYQP
                     VLLEAKQAYLGQKEDHLASRADHLEEFIRFVKGEIIKSVGK"
                     /name="adenylyltransferase"
     gene            11083..11430
                     /locus_tag="AB185_00180"
     CDS             11083..11430
                     /locus_tag="AB185_00180"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_000679416.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ethidium bromide resistance protein"
                     /protein_id="AKL32397.1"
                     /translation="MKGWLFLVIAIVGEVIATSALKSSEGFTKLAPSAVVIIGYGIAFY
                     FLSLVLKSIPVGVAYAVWSGLGVVIITAIAWLLHGQKLDAWGFVGMGLIIAAFLLARSP
                     SWKSLRRPTPW"
                     /name="ethidium bromide resistance protein"
     gene            11424..12263
                     /locus_tag="AB185_00185"
     CDS             11424..12263
                     /locus_tag="AB185_00185"
                     /inference="EXISTENCE: similar to AA
                     sequence:SwissProt:P0C002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydropteroate synthase"
                     /protein_id="AKL32398.1"
                     /translation="MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVG
                     PAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQ
                     GFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRS
                     GVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLP
                     VKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA"
                     /name="dihydropteroate synthase"
     gene            12391..12891
                     /locus_tag="AB185_00190"
     CDS             12391..12891
                     /locus_tag="AB185_00190"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_004194535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyltransferase"
                     /protein_id="AKL32399.1"
                     /translation="MDSEEPPNVRVACSGDIDEVVRLMHDAAAWMSAKGTPAWDVARID
                     RTFAETFVLRSELLVASCSDGIVGCCTLSAEDPEFWPDALKGEAAYLHKLAVRRTHAGR
                     GVSSALIEACRHAARTQGCAKLRLDCHPNLRGLYERLGFTHVDTFNPGWDPTFIAERLE
                     LEI"
                     /name="acetyltransferase"
     gene            13398..14162
                     /locus_tag="AB185_00195"
     CDS             13398..14162
                     /locus_tag="AB185_00195"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_002008502.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="AKL32400.1"
                     /translation="MTDFKWRHFQGDVILWAVRWYCRYPISYRDLEEMLAERGISVDHT
                     TIYRWVQCYAPEMEKRLRWFWRRGFDPSWRLDETYVKVRGKWTYLYRAVDKRGDTIDFY
                     LSPTRSAKAAKRFLGKALRGLKHWEKPATLNTDKAPSYGAAITELKREGKLDRETAHRQ
                     VKYLNNVIEADHGKLKILIKPVRGFKSIPTAYATIKGFEVMRALRKGQARPWCLQPGIR
                     GEVRLVERAFGIGPSALTEAMGMLNHHFAAAA"
                     /name="transposase"
     gene            complement(14461..14745)
                     /locus_tag="AB185_00200"
     CDS             complement(14461..14745)
                     /locus_tag="AB185_00200"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="AKL32401.1"
                     /translation="MRSKTDWPPEVAGVLYLLELQPPEAAMLVGCFLAAVAHPDHAAEL
                     AMFDKLPSEARMAVGRFFSFFLAGGLDDAGREKLHSHMQAWFVRQRRFR"
                     /name="hypothetical protein"
     gene            complement(14930..15154)
                     /locus_tag="AB185_00205"
                     /note="hypothetical protein; disrupted; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo=""
     gene            complement(15230..15364)
                     /locus_tag="AB185_00210"
                     /note="addiction module antidote protein; disrupted;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo=""
     ARG             11084..11427
                     /name="qacEdelta1"
                     /gene="qacEdelta1"
                     /gene_name="quaternary ammonium compound efflux SMR
                     transporter QacE delta 1"
                     /tool="amrfinderplus"
                     /drug_class="QUATERNARY AMMONIUM"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             11425..12260
                     /name="sul1"
                     /gene="sul1"
                     /gene_name="sulfonamide-resistant dihydropteroate synthase
                     Sul1"
                     /tool="amrfinderplus"
                     /drug_class="SULFONAMIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             10129..10916
                     /name="aadA2"
                     /gene="aadA2"
                     /gene_name="ANT(3'')-Ia family aminoglycoside
                     nucleotidyltransferase AadA2"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             8824..10040
                     /name="ere(A)"
                     /gene="ere(A)"
                     /gene_name="EreA family erythromycin esterase"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             8158..8627
                     /name="dfrA32"
                     /gene="dfrA32"
                     /gene_name="trimethoprim-resistant dihydrofolate reductase
                     DfrA32"
                     /tool="amrfinderplus"
                     /drug_class="TRIMETHOPRIM"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             8032..8630
                     /name="dfrA32"
                     /gene="dfrA32"
                     /gene_name="trimethoprim resistant dihydrofolate reductase
                     dfr"
                     /tool="rgi"
                     /drug_class="diaminopyrimidine antibiotic"
                     /identity="99.36"
                     /coverage="126.75"
     ARG             10141..10919
                     /name="aadA2"
                     /gene="aadA2"
                     /gene_name="ANT(3'')"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             8824..10043
                     /name="EreA"
                     /gene="EreA"
                     /gene_name="macrolide esterase"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="98.77"
                     /coverage="100.0"
     Typing          complement(1387..2615)
                     /name="rep_cluster_455"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 cctcgcgcca ggcagtcaga tgtttgtgaa cggtattcgg actgccggtg cccaaacgct
       61 cgcggatcgc gcggatagtc ggctgttgcc cttcgccaac cagcgcatca gcggcggcgg
      121 cgacctgctc aaacgtaatg ccttcacgtg ccataccaga ctcctttcgt atttcgtacc
      181 atataaaacg tatcaataca gatatgatac ataatacaga tatgatatgc aagcgatatt
      241 tttggcccgc atcgtgcgtg gcggatggcc tacgcccggc aaacggggca aaacagccct
      301 ttagagcgtt tttggccgcc tggatagggg aatacgtcgg cggaggcgta aacggcccgc
      361 cacggcccgg aaaacgcggc cagcggggca agcgttgtcg gtattcctga cctcgatgca
      421 gcgggcgtag gtcaaccgtc acaacctggc ggtctgccgc gccaacgagc gcggcgggtt
      481 cgggtcttca agtggaaagg gggtcaaggg ccgtaggggt ggctggcgcg gcccgcagcc
      541 gaaggcgagg acacgggcca ccccggaggg cgaagcgaac ccttgacgcc cttggaacgc
      601 cccaacgctc accggcaggg ggcaggagaa gcaagcgaag cgccgcgcag cctgcacccc
      661 tgacgacaga gggcgactcg ctccccttcc cagcgggaag gggcgggggg gatgggagag
      721 ggtggcgaac cagggcggct tgtcgaggcc acgggcggtg gcctgtcctt tcttgaagac
      781 cttgtggcgg tggcgtatgg atgcgggcgg ttcttggcct gggcggtggt gccgcgaccg
      841 ggggcaccat ccggccccct ttgggggcct cgatatgcgg gtgagcgcgt agcgcgaggg
      901 gtgcagcgaa gcgaaactcc tgggggatgc cgggtgggag cgcgaagcgc gggcggaggg
      961 ccgcttgcgg cccgcaggag ccggcagggg gcttgccccc taagaggcgg agcggtcttt
     1021 ggtgggcgct gcgttttcca cagcgagcgg ccctccaact atcggttaaa gataaaggta
     1081 aaaactaaag gcataaccta tcggtttagg gggggtctga ttaggcacga tcagggggtc
     1141 tgattaggca tggaaaacgc acccttgggg ggtctgatta ggcatggtgg gggggtctga
     1201 ttaggcgtgg acaacttcac caactaacag gcttgccaac aggctgacgg ggggtgcttc
     1261 cgcccaaggc tgacgtagcc ttgtggcgga ggggggtctg attaggcatg gtgtcaaagt
     1321 gcatgcacct ggttggtttt ttgtcaccaa tgaagcccac ggcgacgcgt gggccgggca
     1381 tcaggctatg aacctttgaa ggggatcggc ggcggcgagg ccatcagcat cacgccaccc
     1441 gtcacctgct tgactcgtgc ttgagggtac acagcgagca cagcgcgcaa ggcatgcaaa
     1501 aacttcttct tgaagtcttt gtcggggtct ttcccttggt actcctggcc gaactgctcg
     1561 cgcagactcg cccaatgcag aacgacgggc ctgccttcga tgcggtgtag tcgctgggct
     1621 agccaggtgt aaacgtccat cgcaagcgca gagcctttca actccatgaa ggcgcgcaaa
     1681 tcgagcggta ccgcatgaga tttcaaggtt tggtagtagt catccgagaa ggttactgaa
     1741 ccgggccaca aggggcgctg ttcctctgtt gaagcgatcc acgcctcgaa atgcttgatg
     1801 ggctttcctt cgtaggtgtg cgcgcgtccg ttggcgttga agcctagggt gatccgacaa
     1861 gccgacaagg cctgaacctg cttgcggaag gtcgtgtaaa cgctgtttct ccccccgttc
     1921 ggggtcttgc caagcatccg cagaaactcg ctcgcgctat cccctaccgg gatctctgcc
     1981 gtattgaatc gcacagcata ggtgttcatc caagccagca tcaggcgcgg catggggccg
     2041 taggggatgg gctgctgaac gaactgcttg ccatcccaca gcttccccgc ttctaccagg
     2101 agtgctgcac cgcctgaatg tctctcaaac gatgtggcgt ctaccttcga tcgaggcaag
     2161 ccaacttggc acatgatcga gtgcatgtag ccgcgatcat catcgtccgg gcgctcgctg
     2221 gcgatctctg cggccttttt gactagtcgc gcttcgcgcg gtgttgtcgg ggtcgtcttt
     2281 ggctttggtg gaatcacctc cggggcgggt gtctcagcct tgggtgttct tgttggtttg
     2341 gccttcgctg gtcgggtgtc agctaccggc gaagcctctg ccttcgactg tgtagttggc
     2401 gccggcgcgg ccggtggcgc tgtgagttgg aacagtggca gcgtcgtcgc tgagtcggtg
     2461 gggtactgat cggggcgata agccaccttg gcggccatgt cggccgcctg atcgggcgtc
     2521 aagcccttcg cctcgaggta gtgccggtat ccctcgcgcc atttgcgcaa ttcggcaggg
     2581 gacggctgcg cgcctacttc actgatcttc ttcatagtcg cgctgccgct ggtaagtccg
     2641 taaaatggtc agtagccatg tgctttcggt tcctttccgt atgccctggt aaggcgctac
     2701 cgagtgtgtc cgcactcgat agcgccgctc tcataccgcg aacgcggccg ttctgccggc
     2761 tctcgcgtta cgcacggccc aggcctgcca gccgtcttgc atcaacaccg tcctacgatc
     2821 gcgcaaccag cgctgaaagc ggcgatgctc agccagcaca gcgccgacaa tctgctcggc
     2881 ctggaactcg cccggccggc catctgcctc gatcaagctc aaggccaact cggtcggtgt
     2941 ggcctcggtt ccgtcgattt cgtcgacgta ggccgcgaag ctgtgcagca gctcgacggt
     3001 ttccggcttg aagccggcca ggatgttcgc ggatgccatt tcaataacct ccattgcggt
     3061 cagatatgcg gcgctttatc ccgcgccacg ttgggaattt atgacgctat gacgccacga
     3121 cgctatagcg tcatagcgtc atacggatag cgtcggcaaa cccttctcag caaaaacctt
     3181 cgacagtcca tcaacagcaa gcgactgaat gctgacgccc tcggagacgg cgagctggtg
     3241 cacacgctcc cactcggcac gcggcaggcg tactgtcagg gcaaccacgt cgcctttccc
     3301 tcgtccacgc tgacgggttt ctgccgactg ctcggcgccc ggctcctggt ctgttgcggt
     3361 ttgctgtgcg gaagcggccc ctttacgggt gaaggctgca agccctgttg gtttgttcat
     3421 tgcatttgct ccttaagcca cgcccaaagg gcgcgaattt cagtggcggc cttgccgtcg
     3481 ctctcgaact cagtcacggc ccggccggtg gccacggctc gcgcgaaggc tctacggtcg
     3541 atgatttcga ccggcgcgat cggcaagccg tattcggcca agacggttcg ggtttctgcg
     3601 atttcagggg atcggaacgg gcaggccgat aggacgaaca cggcgcgaac gccggccgct
     3661 ttgacgatat cgacggcact gccggctgcg gcaatatcga aagcggtggg acgcactgga
     3721 atagcaacca gatcgacagc gcgcacgatg cgcgttgcgt ctggggccgc atggggcgcg
     3781 gtgtctacga tcgccagggt catgcgctcc tggtcggcgg cctcgaggac gcgccccagc
     3841 tcggaagcag cagcagtcgc aacaatgggc acctcctggg aacgagcatc gccccaaacg
     3901 gtggcgctct tttgcgggtc ggtgtcgatg acgacgacgc tctcgcccgc ctcggtggca
     3961 gctacggccg tatgcactgc aagcgttgtc ttaccgctgc cgcccttttg ggcgagaaaa
     4021 gctatctttt tcatggcgtc cctacgtcaa gccttcatgg cgtcttgacg tcattatatg
     4081 cgaataaaaa acggcgtcaa gccgccttga cgcaatgacg tcaaaacgtc attgcgtcat
     4141 gtgctgtagg ctaggttttg gtaagcggcg cagatggaat tgccgttagc gacagcacac
     4201 ggcggcggaa gtcgtcgtac tcgtcgccag ccctgagcga cagggcggcc agcgaataaa
     4261 agcgatcggt cgatggtgat tcgctgcggg ccttcaccat gtccagccgc ccgacattga
     4321 ccaccgtcca gcactcggta aagccgcgct gccgcgcctt ctggtggctc ttttccgctt
     4381 ctccgatgcg gttgtggatg ttggatacat ccgttccgct cttgacctcg atagcaacca
     4441 cgttgcggta atgctggtgc tccatttcct cgcggatgat gatgtcaggg tctggcgcga
     4501 actcgatcag gaacgggcgg cccgtggcgc tattcacctc gatggcgctt tcgcgcacct
     4561 cagcggcggc atgggcgacg atctcccgga tgatctcgaa cacctgcacg atgccatcgg
     4621 tgccgcgctg gttgttggcc ccaccgcgta gctgcgggcc tacggttagc agggtcaaat
     4681 catccagcaa ttcccggctg acgcgcagcg ggccaacacc ggccagcagc gccgatgcag
     4741 tggcgcagaa cgccacgcat aagtcgggta ggtcagcggc tgccgtcttg ctggtcttgc
     4801 ccttttcctc catcgacttg aagtaaccga caccgaagcc tttgtcgcgc ccgtaaaact
     4861 ccttctggct gtagcccatc agcagccggt aataacccag caggtaggga ttcgcctcca
     4921 ggacggcagg cacggcgaac agcagttcag cccgcaagcc gtactgcgca agggtcgcca
     4981 agtctgccgg ggggacgtac tcggcaagct gcttgtccag ctcggcaatg tccatgtccc
     5041 gcacggtttc cagcagggcg ctttgcagat agacagcccg gaaccgctta agggcgaaag
     5101 cgaagtcgat ttgcaacttc ggcggcggaa aattgatctt gttaggggtc gtcatgcggc
     5161 ggcgatcctt atcacgttgc tgtcctgccc ttgcaggcga tcagccgcca aggccacata
     5221 ttcggggttc agttcgatgc caacgtattg ccggttttcg tcctggcaca cgaggcccac
     5281 ggttcccgac ccaaagaacg gatcgaggac gtaatcaccc ggctcggtcg atgcttggat
     5341 gcaaggccgg atcaggtcag gcgggaaggt ggcgaagtga gcaccggcaa aaggcctggt
     5401 gttcacatgc cagactgagc ggcgattacg cagaccgccg ccgtccgcag gctcccggac
     5461 ggcctgccag tcgtagtaat acttctccga cttggtgagc atgaatagaa actcatgcga
     5521 gcgagccggg cgatccttga cgctctcggg catcgcgttt ggcttgttcc acacaatgtc
     5581 actgcgcaga taccagccat catcctgcaa ggcgaacgcc agccgccacg gaatgccgat
     5641 caagtccttt ggcttcaagc cctcgggcgt gtcaggtcga acgtccatcg cccgggccgg
     5701 gttcttcttg tccggggctc gataacctcg attgccgctt gtgtagccgt cgccgatgtt
     5761 cagccaaagg gtgccgtcat ccgtcagcac gcgccgcacc tcggcgaaga tggccaccag
     5821 tcgatgcagg aactggggca tggtgctctc aagcccgatt tgttcttcga tgccgtaatc
     5881 gcgcagcccc cagtagggcg gtgaagtgac cacacagcgc acagacccgg atggcagacg
     5941 gcgcagcacg gtcagggcgt ccccctcaaa aagcgtcgag ccgcgcaagg tgagcggctc
     6001 ggggcgctgg attcgctcaa cgccagacgg cgcggcggtt tttgcttttg gcatgttgtt
     6061 atgtcctctc aatcgtggcg cggctgcacc acgccgcaat gcttgtaaat cgttgtccgt
     6121 gacacgccgt aatctcgggc gagttcggcc acgcaggtgt tcgggtcgcg cagtagcgcc
     6181 ttgatgtggc gtatctgctt ggcgtccagt ttcggcttgc ggccaccgga tcggccacgg
     6241 gcgcgggccg cttccaagcc cgcccgggtt cgttcgcgga tcaagccgcg ctcaaactcg
     6301 gccagcgccg cgaaaacatg gaattgcagc ttgcccgccg cgctccctgt ctcgatcttt
     6361 tcggtcaggc tctcgaactg cacgccgcgc tgctcaaggt cggccacgat ctgcaccaga
     6421 tcgggcaggc tgcgtccgag tcgatccagc cgccacacga cgagggtatc cccggcccgg
     6481 agcgccttcc ggcactgctc aagctccggg cgtgccgcgc tcttgccgct ggccgcttcc
     6541 tcgtagatgg tcgagcaccc ggcctgccgg agtgcgtccc gttgcaggtc aagattctga
     6601 tcgtcggtcg aaacgcgggc atagccgatg cgttgattca tggacagttc cgccacattg
     6661 aaagctgaac gaataaatga acactttacc gcatctggat aaccccggac agggaaaaac
     6721 gctgactgtc catcaaacga ccgttttctg gacagccgca gaacaacaag ggccagcaaa
     6781 agctgtcgtt ttcagaagac ggctgcactg aacgtcagaa gccgactgca ctatagcagc
     6841 ggaggggttg gatccatcag gcaacgacgg gctgctgccg gccatcagcg gacgcaggga
     6901 ggactttccg caaccggccg ttcgatgcgg caccgatggc cttcgcgcag gggtagtgaa
     6961 tccgccagga ttgacttgcg ctgccctacc tctcactagt gaggggcggc agcgcatcaa
     7021 gcggtgagcg cactccggca ccgccaactt tcagcacatg cgtgtaaatc atcgtcgtag
     7081 agacgtcgga atggccgagc agatcctgca cggttcgaat gtcgtaaccg ctgcggagca
     7141 aggccgtcgc gaacgagtgg cggagggtgt gcggtgtggc gggcttcgtg atgcctgctt
     7201 gttctacggc acgtttgaag gcgcgctgaa aggtctggtc atacatgtga tggcgacgca
     7261 cgacaccgct ccgtggatcg gtcgaatgcg tgtgctgcgc aaaaacccag aaccacggcc
     7321 aggaatgccc ggcgcgcgga tacttccgct caagggcgtc gggaagcgca acgccgctgc
     7381 ggccctcggc ctggtccttc agccaccatg cccgtgcacg cgacagctgc tcgcgcaggc
     7441 tgggtgccaa gctctcgggt aacatcaagg cccgatcctt ggagcccttg ccctcccgca
     7501 cgatgatcgt gccgtgatcg aaatccagat ccttgacccg cagttgcaaa ccctcactga
     7561 tccgcatgcc cgttccatac agaagctggg cgaacaaacg atgctcgcct tccagaaaac
     7621 cgaggatgcg aaccacttca tccggggtca gcaccaccgg caagcgccgc gacggccgag
     7681 gtcttccgat ctcctgaagc cagggcagat ccgtgcacag caccttgccg tagaagaaca
     7741 gcaaggccgc caatgcctga cgatgcgtgg agaccgaaac cttgcgctcg ttcgccagcc
     7801 aggacagaaa tgcctcgact tcgctgctgc ccaaggttgc cgggtgacgc acaccgtgga
     7861 aacggatgaa ggcacgaacc cagtggacat aagcctgttc ggttcgtaaa ctgtaatgca
     7921 agtagcgtat gcgctcacgc aactggtcca gaaccttgac cgaacgcagc ggtggtaacg
     7981 gcgcagtggc ggttttcatg gcttgttatg actgtttttt tgtacagtct atgcctcggg
     8041 catccaagca gcaagcgcgt tacgccgtgg gtcgatgttt gatgttatgg agcagcaacg
     8101 atgttacgca gcagggcagt cgccctaaaa caaagttagc catatcggga gttaaattga
     8161 aaatttcatt gatttctgca gtgtcagaaa atggcgtaat cggtagtggt cctgatattc
     8221 cgtggtcagc aaaaggtgag cagctaatct ttaaggcgct cacatacaat cagtggcttc
     8281 ttgttggaag gaaaacattt gactctatgg gagttcttcc aaatcgcaaa tatgcagtag
     8341 tgtcaaagaa tggaatttca gggtcaaatg aaaacgtctt ggtttttcct tcaatagaaa
     8401 atgctttgca agaactatct aaaattacag atcatgtata tatttcgggt ggggggcaaa
     8461 tctatgaaag ccttattgaa aaagcagata taattcatct atctactatt catgttgagg
     8521 ttgaaggtga tattaaattc cctatattac ctgaaggttt caacttggtt tttgaacagt
     8581 tttttgtgtc taatataaat tatacatatc aaatttggaa aaaaggctaa caagtcgttg
     8641 cagcaccagt cgctccgctc cttggacagt ttttaagttg tggttttatg gttttgctgc
     8701 gcaaaaatat tccataaaac cacaacttaa aaactgccgc tgaactcggc gttatgctgt
     8761 gacccgggtt gttggcgaag cgaacgtatg gcgattaaag taataaacgc aaaggtaaaa
     8821 taatgacgtg gagaacgacc agaacacttt tacagcctca aaatctggac ttcaatgagt
     8881 ttgagattct tacttccgta attgagggcg cccgaattgt cggcattggc gagggcgctc
     8941 attttgtcgc ggagttttca ctggctagag caagtcttat ccgctatttg gtcgaaaggc
     9001 atgattttaa tgcgattggt ttggaatgtg gggcgattca ggcatcccgg ttatctgaat
     9061 ggctcaactc aacagccggt gctcatgaac ttgagcgatt ttcggatacc ctgacctttt
     9121 ctgtgtatgg ctcagtgctg atctggctga aatcatatct ccgcgaatca ggaagaaaac
     9181 tgcagttagt cggaatcgac ttacccaaca ccctgaaccc aagggacgac ctagcgcaat
     9241 tggccgaaat tatccagctc atcgatcacc tcatgaaacc gcacgttgat atgctgactc
     9301 acttgttggc gtccattgat ggccagtcgg cggttatttc atcggcaaaa tggggggagc
     9361 tagaaacggc tcggcaggag aaagctatct caggggtaac cagattgaag ctccgcttgg
     9421 cgtcgcttgc ccctgtactg aaaaaacacg tcaacagcga tttgttccga aaagcctctg
     9481 atcgaataga atcgatagag tatacgttgg aaaccttgcg tataatgaaa actttcttcg
     9541 atggtacctc tcttgaggga gatacttccg tacgtgactc gtatatggcg ggcgtagtag
     9601 atggaatggt tcgagcgaat ccggatgtga agataattct gctggcgcac aacaatcatt
     9661 tacaaaaaac cccagtctcc ttttcaggcg agcttacggc tgttcccatg gggcagcacc
     9721 tcgcagagag ggtgaattac cgtgcgattg cattcaccca tcttggaccc accgtgccgg
     9781 aaatgcattt cccatcgccc gacagtcctc ttggattctc tgttgtgacc acgcctgccg
     9841 atgcaatccg tgaggatagt atggaacagt atgtcatcga cgcctgtggt acggagaatt
     9901 catgtctgac attgacagat gcccccatgg aagcaaagcg aatgcggtct caaagcgcct
     9961 ctgtaaaaac gaaattgagc gaggcatttg atgccatcgt ctgtgttcca agcgccggca
    10021 aggacagcct agttgcccta taggaaaccg gaaatgaaaa tgagggagca taacctgcga
    10081 atccaccgga cggttttcaa ccgccggtga tcagcgcgtt agacatcatg agggtagcgg
    10141 tgaccatcga aatttcgaac caactatcag aggtgctaag cgtcattgag cgccatctgg
    10201 aatcaacgtt gctggccgtg catttgtacg gctccgcagt ggatggcggc ctgaagccat
    10261 acagcgatat tgatttgttg gttactgtgg ccgtaaagct tgatgaaacg acgcggcgag
    10321 cattgctcaa tgaccttatg gaggcttcgg ctttccctgg cgagagcgag acgctccgcg
    10381 ctatagaagt cacccttgtc gtgcatgacg acatcatccc gtggcgttat ccggctaagc
    10441 gcgagctgca atttggagaa tggcagcgca atgacattct tgcgggtatc ttcgagccag
    10501 ccatgatcga cattgatcta gctatcctgc ttacaaaagc aagagaacat agcgttgcct
    10561 tggtaggtcc ggcagcggag gaattctttg acccggttcc tgaacaggat ctattcgagg
    10621 cgctgaggga aaccttgaag ctatggaact cgcagcccga ctgggccggc gatgagcgaa
    10681 atgtagtgct tacgttgtcc cgcatttggt acagcgcaat aaccggcaaa atcgcgccga
    10741 aggatgtcgc tgccgactgg gcaataaaac gcctacctgc ccagtatcag cccgtcttac
    10801 ttgaagctaa gcaagcttat ctgggacaaa aagaagatca cttggcctca cgcgcagatc
    10861 acttggaaga atttattcgc tttgtgaaag gcgagatcat caagtcagtt ggtaaatgat
    10921 gtctaacaat tcgttcaagc cgaccgcgct acgcgcggcg gcttaactcc ggcgttagat
    10981 gcactaagca cataattgct cacagccaaa ctatcaggtc aagtctgctt ttattatttt
    11041 taagcgtgca taataagccc tacacaaatt gggagatata tcatgaaagg ctggcttttt
    11101 cttgttatcg caatagttgg cgaagtaatc gcaacatccg cattaaaatc tagcgagggc
    11161 tttactaagc ttgccccttc cgccgttgtc ataatcggtt atggcatcgc attttatttt
    11221 ctttctctgg ttctgaaatc catccctgtc ggtgttgctt atgcagtctg gtcgggactc
    11281 ggcgtcgtca taattacagc cattgcctgg ttgcttcatg ggcaaaagct tgatgcgtgg
    11341 ggctttgtag gtatggggct cataattgct gcctttttgc tcgcccgatc cccatcgtgg
    11401 aagtcgctgc ggaggccgac gccatggtga cggtgttcgg cattctgaat ctcaccgagg
    11461 actccttctt cgatgagagc cggcggctag accccgccgg cgctgtcacc gcggcgatcg
    11521 aaatgctgcg agtcggatca gacgtcgtgg atgtcggacc ggccgccagc catccggacg
    11581 cgaggcctgt atcgccggcc gatgagatca gacgtattgc gccgctctta gacgccctgt
    11641 ccgatcagat gcaccgtgtt tcaatcgaca gcttccaacc ggaaacccag cgctatgcgc
    11701 tcaagcgcgg cgtgggctac ctgaacgata tccaaggatt tcctgaccct gcgctctatc
    11761 ccgatattgc tgaggcggac tgcaggctgg tggttatgca ctcagcgcag cgggatggca
    11821 tcgccacccg caccggtcac cttcgacccg aagacgcgct cgacgagatt gtgcggttct
    11881 tcgaggcgcg ggtttccgcc ttgcgacgga gcggggtcgc tgccgaccgg ctcatcctcg
    11941 atccggggat gggatttttc ttgagccccg caccggaaac atcgctgcac gtgctgtcga
    12001 accttcaaaa gctgaagtcg gcgttggggc ttccgctatt ggtctcggtg tcgcggaaat
    12061 ccttcttggg cgccaccgtt ggccttcctg taaaggatct gggtccagcg agccttgcgg
    12121 cggaacttca cgcgatcggc aatggcgctg actacgtccg cacccacgcg cctggagatc
    12181 tgcgaagcgc aatcaccttc tcggaaaccc tcgcgaaatt tcgcagtcgc gacgccagag
    12241 accgagggtt agatcatgcc tagcattcac cttccggccg cccgctagcg gaccctggtc
    12301 aggttccgcg aaggtgggcg cagacatgct gggctcgtca ggatcaaact gcactatgag
    12361 gcggcggttc ataccgcgcc aggggagcga atggacagcg aggagcctcc gaacgttcgg
    12421 gtcgcctgct cgggtgatat cgacgaggtt gtgcggctga tgcacgacgc tgcggcgtgg
    12481 atgtccgcca agggaacgcc cgcctgggac gtcgcgcgga tcgaccggac attcgcggag
    12541 accttcgtcc tgagatccga gctcctagtc gcgagttgca gcgacggcat cgtcggctgt
    12601 tgcaccttgt cggccgagga tcccgagttc tggcccgacg ccctcaaggg ggaggccgca
    12661 tatctgcaca agctcgcggt gcgacggaca catgcgggcc ggggtgtcag ctccgcgctg
    12721 atcgaggctt gccgccatgc cgcgcgaacg caggggtgcg ccaagctgcg gctcgactgc
    12781 cacccgaacc tgcgtggcct atacgagcgg ctcggattca cccacgtcga cactttcaat
    12841 cccggctggg atccaacctt catcgcagaa cgcctagaac tcgaaatcta acgtccgttc
    12901 gggcatcgag gtccatgtcg gggtgggacg ggcccgtggc ttcaagatca cttgcagtcc
    12961 gaccgcgatg tcttggttgc gcgagaggtt gtcgatatcc tccacttcca tcatcaaccc
    13021 tggataatgc cgccgccgtc atcgccgccg acgcccgtgc cgggcttttc gggcctgtca
    13081 ggcttgctcg gccttcagcc tgcctgggcg agatctccgg cggacggatt aacggcggag
    13141 cttcgccgcc tttcgtgcgt gtgaaggccg aagatagttc tctcaaaaac atccgtttat
    13201 gagagatacc aaatgtcatt ttcagaagac gactgcacca gttgattggg cgtaatggct
    13261 gttgtgcagc cagctcctga cagttcaata tcagaagtga tctgcaccaa tctcgactat
    13321 gctcaatact cgtgtgggct ctgttgcaaa aatcgtgaag cttgagcatg cttggcggag
    13381 attggacgga cggaacgatg acggatttca agtggcgcca tttccagggt gatgtgatcc
    13441 tgtgggcggt gcgctggtat tgtcgctatc cgatcagcta tcgcgacctt gaggaaatgc
    13501 tggcggaacg cggcatttcg gtcgaccata cgacgatcta tcgctgggtc cagtgctacg
    13561 ccccggagat ggagaagcgg ctgcgctggt tctggcggcg tggctttgat ccgagctggc
    13621 gcctggatga aacctacgtc aaggtgcggg gcaagtggac ctacctgtac cgggcagtcg
    13681 acaagcgggg cgacacgatc gatttctacc tgtcgccgac ccgcagcgcc aaggcagcga
    13741 agcggttcct gggcaaggcc ctgcgaggcc tgaagcactg ggaaaagcct gccacgctca
    13801 ataccgacaa agcgccgagc tatggtgcag cgatcaccga attgaagcgc gaaggaaagc
    13861 tggaccggga gacggcccac cggcaggtga agtatctcaa taacgtgatc gaggccgatc
    13921 acggaaagct caagatactg atcaagccgg tgcgcggttt caaatcgatc cccacggcct
    13981 atgccacgat caagggattc gaagtcatgc gagccctgcg caaaggacag gctcgcccct
    14041 ggtgcctgca gcccggcatc aggggcgagg tgcgccttgt ggagagagct tttggcattg
    14101 ggccctcggc gctgacggag gccatgggca tgctcaacca ccatttcgca gcagccgcct
    14161 gatcggcgca gagcgacagc ctacctctga ctgccgccaa tctttgcaac agagcccgcg
    14221 cgcgaaagcg cggctgtttt ccttgcgcag caagggtttt atgccggttc cgccctttcg
    14281 gtgtcgccgc gatgtgtctt cggtgtcgcc gcgctaaaag ccttgcagca caaggctttt
    14341 agcgaagcaa cgggagttgc gtggtgtgtg acaagttttc tgggggtgcg gggccgtccc
    14401 gcaagccagc atcgccctct gtccatccct tgcccggccc tagtggatga gtccggccat
    14461 tcaccgaaat cggcgctgac ggacaaacca tgcctgcatg tgcgaatgca gcttttcgcg
    14521 cccggcatcg tccaggccgc ccgccaggaa aaacgagaaa aaccgaccga cggccatccg
    14581 ggcctctgac ggcaatttat cgaacatcgc cagctcggcc gcatgatcgg gatgggccac
    14641 agccgccaga aagcagccca ccagcatcgc cgcctctggc ggctgcaatt cgagcaaata
    14701 cagtacgccg gccacctcgg gcggccagtc ggttttactg cgcatggcga tgcaagatgc
    14761 ggtagcactg caccgcctca tcgtgggtga ggtcgccccg gatcagcagc gcctgcaccg
    14821 ccaaatcatc cgcgctcatg gccagcccct ccaaggccag cgaagcatgc acctggtcga
    14881 aatcggcgcg gcgctgctcc tggcgggcgt ggtcgttttc agcttggcca tacagccggc
    14941 gcgccagtgg cgcatagcgc gaaatcgccg cctcgatgcc ggcgctgtcg cgcgggtcga
    15001 gatcgtcccg ctccccggcc agcgccgcct tcatcgcccc ggccacgcgc aaaaccgcct
    15061 cattcggctg cgcctgctcg cgctcgcgtc ccatgatttc ggcgtagtgg gcaatcaacg
    15121 ccccgatcac atcacacgcc acttcgtagc gcacgccggc ccggtcaaag aggcccgccg
    15181 aaggcgcaga atcagtcggc gcagcggcct ggctgacgcg cagcacatcc gccatttgcc
    15241 gcaaaccggc gcgcacgtcg gcaggttcgc catcggccaa cacctggcgc agatagtcgg
    15301 cggcaaatcg gggttcggcc tgaaacatgc cggccatcgc ttcgttgtgg tcacggtctt
    15361 tcatcggttt ttcgttcctt ggtggtgagg gcttcgagtt gccccgccag gcgcgcggcc
    15421 tgctcgcgcg cctcggcggc caccttgcgg gcttcgtcgc gttctgcttg cacctgccgg
    15481 gcttcctgcg cggcagcggc tcgggcttct tcgttggcct gtgccgcctt ggcggcctgc
    15541 tgctcgatct gctcgacgcg ggcctctgca cgggccaccc gttcagcgca tgcctccagt
    15601 ttggcggcca gcacggcggc ctgctgttcg gcggcggtgc ggccctgctg cgcatcggcc
    15661 agcgcggcgc gtaggcgctc gatctcggcg gcctgctcgg tctgccgttc ggcctgtgcc
    15721 tcgatcttga ggcgggccgt ggccagctcc acccgcgccg attcggcggc ctgttgctcg
    15781 cgctcgatgc gctgcgcctg gtcggccaag tcggcggctt gctgctcggc cttgcccgcc
    15841 agagtgtcac gctcgcgggt gagttctgcc acctgctcgg ccagagcatc gcgctcggcc
    15901 tcgatcacct caccagcggc agccagctcg acggcctcgc cctgggcctg caccaagcgg
    15961 ccctcgatct cggcgcgggc ttgggcggct gcgcgctcga tctcggcggc aatagcagcc
    16021 gtcaatgcct gaggcagttc cggcgcagcg gcagccgcca ccgggcgag
//
