LOCUS       NZ_OP378673.1           7195 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_OP378673.1 Enterococcus faecium strain VRE32553 plasmid
            pVRE32553_4, complete sequence.
ACCESSION   NZ_OP378673
VERSION     NZ_OP378673.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-06-07 17:01:24
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 2122
            Orig. end    :: 9317
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..7195
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:5375]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5375
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..7195
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..7195
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             complement(235..1149)
                     /locus_tag="ctg1_3"
                     /transl_table=11
                     /translation="MATIKVSRTTSCSRAINYAEPRATIKTGINCDVDYAKSEMKQIRM
                     LYGKDDRVQAHLLIQSFRPGEITAEKANQLGAEYAKKIAPDHQIAIYTHTDKDHIHNHI
                     VINSVNLETGKKFQAHGQAFLNKCYDLNDEICLAHNLPITERGKKPEKRTMSEIKLKEK
                     NEPVWKDEIRIAIDQTMKNKKTRTYDQFCNSLKTLGIHCFNRGKNFTYELIHKKKKVRS
                     NRLGKDYEKETILHELDRRERTYNQQRTNELRRARASIRETAEEVRREQRTLTPEQPEI
                     RPARRNHEQHVERGTDHQQELSL"
     CDS             complement(1131..1511)
                     /locus_tag="ctg1_4"
                     /transl_table=11
                     /translation="MSEQNQNLASNSSKKYTYRSEPKQISFRVSESEFAKLKQSAEALQ
                     MSVPAFVKAKAQNARLVTPKVAPDIAQAIARDLAKAGGNINQIAKWCNTHQHDVASGDA
                     QRLSENLKIMQKELQKIWQQLR"
     CDS             complement(1832..1993)
                     /locus_tag="ctg1_5"
                     /transl_table=11
                     /translation="MKLNQLKNGRVIARFLVEVTKSGHIIIMTRRKSDKKLAKNIAECL
                     IKLSVLAK"
     CDS             complement(1953..2090)
                     /locus_tag="ctg1_6"
                     /transl_table=11
                     /translation="MILLKKEYEKFYDRLIYSLQLPKKLNRQLQKTYETKSTEEWESYC
                     "
     CDS             complement(2204..2824)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 136.7; E-value:
                     1.7e-41)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_7"
                     /transl_table=11
                     /translation="MILSVENFTLSINKKKIKQNWNFSISEKDFIIVTGKSGSGKTTLL
                     NNLSLIDKQYTGNLFYFEKKVSKHDIQRLRRNHISYLFQNYALLENQTVQYNFELAKKF
                     NSNISNDHIYNLLTDFSLPKDILKEKIFLLSGGEQQRIALIRNMLKPFDILFADEPTGN
                     LDKENSTFIMNFLKNLTEKEKKAVVLVTHDLNVLNYGTNIIEL"
     CDS             complement(2821..4947)
                     /locus_tag="ctg1_8"
                     /transl_table=11
                     /translation="MLKKINAVLSLFVCITILFFSTNVINGIKTSEALYKNTAEIHMQY
                     KDDMDFNSYINALYEISTQENINISQYSFTAVNQLTILATNPNANKHWKFSKKNILARN
                     DSKVHYTNNKNSKYQLKLPNNFLNINIYPFSHVENIGLSEILYVQGNSNKLIPVLKKYG
                     TPTISNINQSDTFQINTNIVLVICYLSIFIVITTIIFAFSKMKEITLKKMLGYNSFDTI
                     KDSIKELNLLFCSLIITFILSIFLSIYYSNENFFLSFLLCSIFHFIISFLFIIVTLSIY
                     HLSSIKNYLKNSRPLKLNLCILNICLFLSMILLLIASTKVINTHNEAENNSLKYWERTT
                     NLYKTNITNQLNRNNTVEENNYLKKASKFVYKIQKNYKTFIIAPYNYATIQENNKEFFI
                     GQKVYPNFEDYVSQPAGAGICVDLNYLKYYNPISFEESTDLNLINSDPLTTYILVPKKY
                     KEYAKMIEKNYLEDIQFRLEDSPPQAPYKNPNLKNLKIKLIFVNNNQKYFSFNTLYGKA
                     KDNYTITDPIVRVINPEITESLFWGNILTSDGGLFFDQKHTSNQNFFNQINPYIKEFNL
                     ENIINFSYSVFQETGELLSQKKVNKLNAYLQYLLILGLFIIINFQMIFVSFTINSKKIA
                     LKKIFGYSPISQVLDLCLLPFTIELFATMCFQLIFSKNTYLYFIIFMIFLINLITSIII
                     YKKNSFKYFKENIL"
     CDS             complement(5001..5375)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_9"
                     /sec_met_domain="Lactococcin_972 (E-value: 1.7e-09,
                     bitscore: 28.1, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKFLCLSALMGVLLTSGGIASATEALNLDVPEDHTAIYGGGMEA
                     TEEGFSSSKLRYAAGGGDFNCGVNGFKVYANYYHARAKHSATAKNGRGGQVRSVQKAGV
                     RAYATCNATLTGNTGWWNVY"
     CDS             5508..5969
                     /gene_functions="other (smcogs) SMCOG1148:hypothetical
                     protein (Score: 61.9; E-value: 1.6e-18)"
                     /gene_kind="other"
                     /locus_tag="ctg1_10"
                     /transl_table=11
                     /translation="MEDLGSKLRELRVKKGYTQEYVARKFNVTRQTISKWENNKTTPDI
                     ETLKKICEFYSTNINSILNEDNSKNKKNNLLVLTAIIFNIFVTILGLFELIQMNFFSFT
                     HGIFTWFALSGLIVIDILNYFYIYYSYLKNEKFFYTMFFPLVILIILLS"
     CDS             complement(6281..6451)
                     /locus_tag="ctg1_11"
                     /transl_table=11
                     /translation="MTRKNLLFGSILLGILGFSPMLLSVINKGNKHGELKLNPNYYNSP
                     NEELFVKETDK"
     CDS             complement(6467..7006)
                     /locus_tag="ctg1_12"
                     /transl_table=11
                     /translation="MQPKETFTIKELSELFEISRQAISKHVDKLDPSLLAKNERGYKVV
                     LRSGVLQLASNLGNQRLLYRLHEYEQENDKNVYISSKNVIVNELLDKLREENEFLREQL
                     SLKEQNNSNMQKLLDQQQQLTLQANQQIEKLQEQLQLAYTEETPEDESTTILSEETESI
                     EKHTKKKKQKWWQLWK"
     CDS             complement(7034..7195)
                     /locus_tag="ctg1_13"
                     /transl_table=11
                     /translation="MKEFLNVNSTHPAIFKTFEIKKIKAYKGNKIGSLQIYFEENIPSI
                     TLDNWLEK"
ORIGIN
        1 cctccccata ctaaccaaaa tgcgaacagt gtcaggacta agcaacataa gggggcaaga
       61 aaatccaatg atcgttgaat aagcaccttt ttctgttcct tatttcgctg gtctaatagc
      121 tcttgatgga gttttttaac ttgtaaatca atcgtagttt gtatcctttc ttgcgtataa
      181 ggaacgagaa aagcacgttg tttctttatt tcgttttcta tgtcttttaa cgttttagag
      241 cgataattct tgttggtggt ctgttcctct ttcaacgtgt tgttcatggt ttcttcgagc
      301 cggtctaatt tccggttgtt caggcgtaag agttcgttgt tctcttcgta cttcttctgc
      361 agtttcgcga atgctagctc gagctcttcg tagctcgttg gttcgctgtt ggttataggt
      421 tcgttctcgt ctgtccagct catgtaaaat cgtctccttt tcgtagtcct ttcctagtct
      481 gttggatcgt acttttttct ttttgtggat caattcgtaa gtgaaatttt tcccgcgatt
      541 gaagcaatga atccccaatg ttttgaggga attacaaaat tggtcatagg ttctggtttt
      601 tttgtttttc attgtttgat cgatcgcaat ccgaatttcg tctttccaaa caggttcatt
      661 tttttctttt aattttattt cagacatggt tcgtttttct ggtttctttc ctcgctcagt
      721 gattggtaag ttatgtgcaa gacaaatctc gtcatttagg tcataacatt tgtttagaaa
      781 tgcttgacca tgagcttgaa atttttttcc agtctccaga ttaacggagt taatgacaat
      841 gtgattatga atatggtctt tgtctgtatg tgtgtaaata gctatttggt gatcgggggc
      901 tatttttttt gcatactctg cccctagttg attagctttt tcagcggtaa tttctcctgg
      961 tcgaaaagat tgaatcaata agtgtgcctg tacacggtcg tcttttccat acagcatgcg
     1021 aatttgtttc atttcacttt tggcataatc gacgtcacag tttattcctg ttttaatggt
     1081 tgctcgtggt tctgcgtaat taattgcacg actacaagaa gtggttcggc ttaccttaat
     1141 tgttgccata tcttttgtag ctccttttgc atgattttta ggttttcgga taaacgttga
     1201 gcgtcaccag aagcaacgtc atgttggtgt gtattgcacc acttagcaat ttgattgata
     1261 ttccctccag ctttggctaa atcgcgcgcg attgcctggg caatgtctgg cgccactttc
     1321 ggtgtcacca gacgcgcgtt ttgtgccttg gctttcacga aagccggcac actcatttgc
     1381 aaagcttcag ccgattgctt cagctttgca aattcggatt cgctcactcg aaaactgatt
     1441 tgttttggct cggatcgata ggtatatttt ttagaagaat tgctagccaa attttgattt
     1501 tgttcgctca taagtcccac cctttcagta cgtcctacgg acgtatcgtt cgcaatacca
     1561 ttgtacctaa aaaggtacaa tgagtaaagc tcactaaaag ggtttggcaa gctctatatt
     1621 tgctagccaa atacctacgt atttagtgca aataaccgct tgtcaaaggg gcgcaagctc
     1681 ccccttgaat ccccctcaaa agccacgctc cacaatacaa aaaaagctag caaatgctag
     1741 ccactttttg taaagtttcg cttatttcac cgaagatgaa attgttgctt tgcaacaaaa
     1801 aacataaatg cttttttgtg taaactacta actatttagc taaaactgat agttttatta
     1861 aacattcagc aatattttta gccaattttt tatcagactt tcggcgagtc attatgataa
     1921 tatgtccact ttttgttact tctaccaaaa atctagcaat aactctccca ttcttcagtt
     1981 gatttagttt cataagtctt ttgtaattga cggtttaatt tttttggcaa ttgcaaagaa
     2041 taaataagtc tatcataaaa tttttcatac tcttttttca ataaaatcac ttgggtgcct
     2101 cctttttatt aagtgattat ttaaattttg ggataggaga gatggaatat aaaataaata
     2161 cccgtggtgc tagttttaaa tcagctagca tcacgggtaa aaattataat tctataatat
     2221 tagttccata gtttagaaca tttaagtcat gtgttactag tacaacggct tttttttctt
     2281 tttctgttaa atttttcaga aagttcatta taaaagttga gttttcttta tctaaatttc
     2341 ctgtaggttc atctgcaaat aatatatcaa atggttttaa catatttcta attaatgcta
     2401 ttctttgttg ttctccaccg cttaagagaa agattttttc ttttaagata tcttttggca
     2461 aagaaaaatc tgttaataaa ttataaatat gatcattgga aatattactg ttaaactttt
     2521 ttgctaattc gaaattgtat tgtactgttt gattttcaag aagagcatag ttttgaaata
     2581 aatagctaat atgatttctt cgtagacgtt gtatatcatg tttagaaact ttcttttcaa
     2641 aatagaataa gttaccggta tattgtttat ctattaggct taaattattt aacagagtag
     2701 tttttccact accacttttt cctgttacta taataaaatc tttttctgat attgaaaagt
     2761 tccaattttg tttgatcttt tttttattaa ttgacagggt gaaattctca actgataata
     2821 tcataaaata ttctccttaa aatatttaaa actatttttt ttataaataa taatagaagt
     2881 aattagattt attaaaaaga tcataaaaat tataaaatac aagtaagtgt tttttgaaaa
     2941 tatcaattga aaacacatag tagcaaataa ctctattgta aaagggagta aacataaatc
     3001 taaaacttga cttattggtg aatatccaaa tatttttttt aaagctattt tttttgaatt
     3061 tatagtaaaa ctaacaaaaa tcatttgaaa attaattatt ataaataatc ctaatattaa
     3121 aagatattgt agatatgcat ttaatttatt tacttttttt tgagataata attcaccagt
     3181 ttcttgaaaa acagaataag aaaaatttat gatattttct aggttaaatt cttttatata
     3241 cggattaatt tgattaaaaa agttttggtt tgaagtatgt ttctgatcaa aaaataatcc
     3301 accatcacta gtcaatatat ttccccaaaa taatgattct gttatttctg gattaataac
     3361 tctaactatg ggatcagtta ttgtatagtt atcttttgcc tttccatata aggtattaaa
     3421 actaaaatac ttttggttat tattaacaaa tattagtttt atttttaaat ttttcaaatt
     3481 aggattttta taaggagctt gaggaggaga gtcctcaagt ctaaactgta tgtcttctaa
     3541 ataatttttt tcaatcattt ttgcatattc tttatatttt ttaggtacta gaatgtaagt
     3601 agttagtgga tcagagttta ttaaatttaa gtcagtagat tcttcaaaag aaataggatt
     3661 gtaatatttt agatagttta aatcaacaca tattcctgca ccagcaggtt gactaacata
     3721 gtcttcaaaa tttggataaa ctttttgtcc aataaaaaat tctttattat tctcttggat
     3781 agttgcgtaa ttgtatggcg cgataataaa agttttataa ttcttctgta ttttataaac
     3841 aaatttacta gcttttttca agtagttatt ttcttctacg gtgttgtttc tatttaattg
     3901 attagtaata tttgttttgt ataaattagt agttctttcc caatatttaa gagaattatt
     3961 ttcggcttca ttatgggtat ttattacttt tgtagaagct attaacagaa ggatcatgct
     4021 taagaataga cagatattta atatacaaag atttaactta agtggtcgtg aattttttag
     4081 ataatttttt atactagata aatgatagat acttagagta actatgataa ataaaaaact
     4141 aattataaaa tgaaaaatac tacatagaag aaatgatagg aaaaaatttt cgttactgta
     4201 atatatgctc aaaaaaatag ataaaatgaa agttataatc aaagaacaaa ataagaggtt
     4261 taactcttta atagaatctt ttatagtatc aaaagagtta tagcctaaca ttttttttag
     4321 agtgatttct ttcatttttg aaaaagcaaa tataattgta gtaattacaa taaatatact
     4381 aagatagcag ataacaagaa caatattagt attaatttga aaagtatctg attgattgat
     4441 attggaaata gtaggtgttc catatttttt cagtacagga attaatttgt ttgagtttcc
     4501 ttgtacatat aatatttcac ttaatccaat attttccaca tgagaaaaag gataaatatt
     4561 tatatttaaa aaattatttg gaagttttaa ttggtactta gaatttttgt tattagtata
     4621 atggacttta gaatcgtttc ttgctaatat atttttttta gaaaatttcc agtgtttgtt
     4681 agcgttaggg tttgtagcaa gaatagttag ttggttaaca gcagtaaaac tatattgaga
     4741 aatattaata ttttcttgtg tagatatttc atacaaagcg tttatataac tgttaaagtc
     4801 catatcatct ttatattgca tatgaatttc agcggtattt ttatatagcg cttcagaagt
     4861 ctttatacca tttataacat tagtagaaaa aaatagtatt gtaatgcaga caaaaagtga
     4921 taaaacagcg tttatttttt ttaacatatt ttgaatttcc tttcaaatgt aaataaaaaa
     4981 gagagtttaa actctctttt ttaataaaca ttccaccaac cagtatttcc agtaagtgtg
     5041 gcattgcatg ttgcataagc tcttactcca gctttctgaa ctgatcgtac ttgaccgcct
     5101 cgtccatttt tagctgttgc actatgttta gctctagcat ggtagtaatt tgcataaact
     5161 ttaaatccat taaccccaca gttgaaatcc ccgccgccag cagcatatct caatttacta
     5221 gaagaaaatc cttcttctgt agcttccatt cctcctccgt aaatggcggt atggtcttcg
     5281 ggtacatcta gatttaaagc ttctgtggca ctagctattc ctccactagt taataagaca
     5341 cccattaaag cagaaagaca taaaaatttt ttcataactt atttctccta tcttttttac
     5401 tagaattatt ttattttagt gtgttttata aaataaagaa cttttttggc gcgttagtat
     5461 ttttatgata aaattttatg taaataatcg tttacatagg agaaaaaatg gaggatttag
     5521 gatctaagct aagagaatta agagtgaaaa aagggtatac tcaagaatat gtggcaagaa
     5581 aatttaacgt tacacgtcaa actatttcaa agtgggaaaa taacaaaaca acaccagata
     5641 tagagacact aaaaaaaatt tgtgaatttt atagtactaa cataaattct attttaaatg
     5701 aagataattc aaaaaataaa aaaaataatt tactggtatt gacagctatt atttttaata
     5761 tatttgttac tatattaggt ttatttgaat tgattcaaat gaattttttt agctttacac
     5821 atggaatatt tacttggttt gctctatctg gattaatagt aatagatatc ttaaattatt
     5881 tttatattta ctattcttat ttaaaaaatg aaaaattttt ttatacaatg tttttccccc
     5941 tagttatttt gattatttta ttaagctaat atgaagtagt tagttattta attgcatagt
     6001 tgacataatg tacactatgc caagtagccc ctctaccaat ggatagagac gctcactttg
     6061 tgatttttaa ttggtctagc taaaagcaac tttctaaagc ttgatttttc gcggttatct
     6121 atatctaatt ctttgtgcat ttttatctgt cattttttta agacttgtta ttttttgtaa
     6181 aatatggtaa atttttggta gcgcttcata agcgcgtgct ttttcaagaa taaacactca
     6241 ttatttttta actggctgct cggaagagca gtctttttta ttatttatcc gtctctttta
     6301 caaacaattc ttcgttagga ctgttgtaat aatttggatt caatttcaat tcaccatgtt
     6361 tattcccttt attgattact gacaataaca tcggactgaa gcctagaatt cctagtaaaa
     6421 tagaaccgaa tagaagattt tttcttgtca tgaatgttcc ctccagttat ttccaaagtt
     6481 gccaccattt ttgcttcttc ttttttgtgt gtttttctat cgattctgtt tcttcagaaa
     6541 gaatagtagt tgattcatct tctggagttt cttccgtata agctaattgt aactgttctt
     6601 gcagtttttc gatctgttga tttgcctgta gggtgagctg ttgttgctgg tcgagtaatt
     6661 tttgcatatt agaattattt tgctctttga gggaaagttg ttctcgtaaa aattcatttt
     6721 cttcacgcaa cttatctagc aactcgttta caatcacgtt tttgcttgat atataaacgt
     6781 ttttatcgtt ttcttgttca tactcatgca acctatatag taacctttgg ttacctaagt
     6841 tgctagcaag ttgcaatact ccagaacgta atacaacctt ataaccacgc tcatttttag
     6901 ctaataagga cgggtctaat ttatcaacat gtttagagat tgcttgccta cttatttcaa
     6961 ataattcaga taattccttt attgtaaagg tttctttggg ttgcatgata attgcctcct
     7021 aaattgttag gtattatttc tctaaccaat tatctaaggt aattgaaggt atattttctt
     7081 caaaataaat ttgcagagat cctatcttat ttcctttgta ggctttaatt tttttgattt
     7141 caaaagtttt aaaaatagca gggtgagttg aattaacgtt taaaaattct ttttt
//
