LOCUS       NZ_LR135397.1           5686 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_LR135397.1 Enterococcus faecium isolate E8290 plasmid 4.
ACCESSION   NZ_LR135397
VERSION     NZ_LR135397.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-06-07 15:51:01
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 5686
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..5686
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[311:686]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      312..686
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..5686
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..5686
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             complement(3..179)
                     /gene_functions="other (smcogs) SMCOG1148:hypothetical
                     protein (Score: 58.9; E-value: 1.4e-17)"
                     /gene_kind="other"
                     /locus_tag="ctg1_1"
                     /transl_table=11
                     /translation="MEDLGSKLRELRVKKGYTQEYVARKFNVTRQTISKWENNKTTPDI
                     ETLKKICEFYSTNI"
     CDS             312..686
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2"
                     /sec_met_domain="Lactococcin_972 (E-value: 1.7e-09,
                     bitscore: 28.1, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKFLCLSALMGVLLTSGGIASATEALNLDVPEDHTAIYGGGMEA
                     TEEGFSSSKLRYAAGGGDFNCGVNGFKVYANYYHARAKHSATAKNGRGGQVRSVQKAGV
                     RAYATCNATLTGNTGWWNVY"
     CDS             740..2866
                     /locus_tag="ctg1_3"
                     /transl_table=11
                     /translation="MLKKINAVLSLFVCITILFFSTNVINGIKTSEALYKNTAEIHMQY
                     KDDMDFNSYINALYEISTQENINISQYSFTAVNQLTILATNPNANKHWKFSKKNILARN
                     DSKVHYTNNKNSKYQLKLPNNFLNINIYPFSHVENIGLSEILYVQGNSNKLIPVLKKYG
                     TPTISNINQSDTFQINTNIVLVICYLSIFIVITTIIFAFSKMKEITLKKMLGYNSFDTI
                     KDSIKELNLLFCSLIITFILSIFLSIYYSNENFFLSFLLCSIFHFIISFLFIIVTLSIY
                     HLSSIKNYLKNSRPLKLNLCILNICLFLSMILLLIASTKVINTHNEAENNSLKYWERTT
                     NLYKTNITNQLNRNNTVEENNYLKKASKFVYKIQKNYKTFIIAPYNYATIQENNKEFFI
                     GQKVYPNFEDYVSQPAGAGICVDLNYLKYYNPISFEESTDLNLINSDPLTTYILVPKKY
                     KEYAKMIEKNYLEDIQFRLEDSPPQAPYKNPNLKNLKIKLIFVNNNQKYFSFNTLYGKA
                     KDNYTITDPIVRVINPEITESLFWGNILTSDGGLFFDQKHTSNQNFFNQINPYIKEFNL
                     ENIINFSYSVFQETGELLSQKKVNKLNAYLQYLLILGLFIIINFQMIFVSFTINSKKIA
                     LKKIFGYSPISQVLDLCLLPFTIELFATMCFQLIFSKNTYLYFIIFMIFLINLITSIII
                     YKKNSFKYFKENIL"
     CDS             2863..3483
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 136.7; E-value:
                     1.7e-41)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_4"
                     /transl_table=11
                     /translation="MILSVENFTLSINKKKIKQNWNFSISEKDFIIVTGKSGSGKTTLL
                     NNLSLIDKQYTGNLFYFEKKVSKHDIQRLRRNHISYLFQNYALLENQTVQYNFELAKKF
                     NSNISNDHIYNLLTDFSLPKDILKEKIFLLSGGEQQRIALIRNMLKPFDILFADEPTGN
                     LDKENSTFIMNFLKNLTEKEKKAVVLVTHDLNVLNYGTNIIEL"
     CDS             3597..3734
                     /locus_tag="ctg1_5"
                     /transl_table=11
                     /translation="MILLKKEYEKFYDRLIYSLQLPKKLNRQLQKTYETKSTEEWESYC
                     "
     CDS             3694..3855
                     /locus_tag="ctg1_6"
                     /transl_table=11
                     /translation="MKLNQLKNGRVIARFLVEVTKSGHIIIMTRRKSDKKLAKNIAECL
                     IKLSVLAK"
     CDS             4176..4556
                     /locus_tag="ctg1_7"
                     /transl_table=11
                     /translation="MSEQNQNLASNSSKKYTYRSEPKQISFRVSESEFAKLKQSAEALQ
                     MSVPAFVKAKAQNARLVTPKVAPDIAQAIARDLAKAGGNINQIAKWCNTHQHDVASGDA
                     QRLSENLKIMQKELQKIWQQLR"
     CDS             4538..5452
                     /locus_tag="ctg1_8"
                     /transl_table=11
                     /translation="MATIKVSRTTSCSRAINYAEPRATIKTGINCDVDYAKSEMKQIRM
                     LYGKDDRVQAHLLIQSFRPGEITAEKANQLGAEYAKKIAPDHQTAIYTHTDKDHIHNHI
                     VINSVNLETGKKFQAHGQAFLNKCYDLNDEICLAHNLPITERGKKPEKRTMSEIKLKEK
                     NEPVWKDEIRIAIDQTMKNKKTRTYDQFCNSLKTLGIHCFNRGKNFTYELIHKKKKVRS
                     NRLGKDYEKETILHELDRRERTYNQQRTNELRRARASIRETAEEVRREQRTLTPEQPEI
                     RPARRNHEQHVERGTDHQQELSL"
ORIGIN
        1 tttatgttag tactataaaa ttcacaaatt ttttttagtg tctctatatc tggtgttgtt
       61 ttgttatttt cccactttga aatagtttga cgtgtaacgt taaattttct tgccacatat
      121 tcttgagtat accctttttt cactcttaat tctcttagct tagatcctaa atcctccatt
      181 ttttctccta tgtaaacgat tatttacata aaattttatc ataaaaatac taacgcgcca
      241 aaaaagttct ttattttata aaacacacta aaataaaata attctagtaa aaaagatagg
      301 agaaataagt tatgaaaaaa tttttatgtc tttctgcttt aatgggtgtc ttattaacta
      361 gtggaggaat agctagtgcc acagaagctt taaatctaga tgtacccgaa gaccataccg
      421 ccatttacgg aggaggaatg gaagctacag aagaaggatt ttcttctagt aaattgagat
      481 atgctgctgg cggcggggat ttcaactgtg gggttaatgg atttaaagtt tatgcaaatt
      541 actaccatgc tagagctaaa catagtgcaa cagctaaaaa tggacgaggc ggtcaagtac
      601 gatcagttca gaaagctgga gtaagagctt atgcaacatg caatgccaca cttactggaa
      661 atactggttg gtggaatgtt tattaaaaaa gagagtttaa actctctttt ttatttacat
      721 ttgaaaggaa attcaaaata tgttaaaaaa aataaacgct gttttatcac tttttgtctg
      781 cattacaata ctattttttt ctactaatgt tataaatggt ataaagactt ctgaagcgct
      841 atataaaaat accgctgaaa ttcatatgca atataaagat gatatggact ttaacagtta
      901 tataaacgct ttgtatgaaa tatctacaca agaaaatatt aatatttctc aatatagttt
      961 tactgctgtt aaccaactaa ctattcttgc tacaaaccct aacgctaaca aacactggaa
     1021 attttctaaa aaaaatatat tagcaagaaa cgattctaaa gtccattata ctaataacaa
     1081 aaattctaag taccaattaa aacttccaaa taatttttta aatataaata tttatccttt
     1141 ttctcatgtg gaaaatattg gattaagtga aatattatat gtacaaggaa actcaaacaa
     1201 attaattcct gtactgaaaa aatatggaac acctactatt tccaatatca atcaatcaga
     1261 tacttttcaa attaatacta atattgttct tgttatctgc tatcttagta tatttattgt
     1321 aattactaca attatatttg ctttttcaaa aatgaaagaa atcactctaa aaaaaatgtt
     1381 aggctataac tcttttgata ctataaaaga ttctattaaa gagttaaacc tcttattttg
     1441 ttctttgatt ataactttca ttttatctat ttttttgagc atatattaca gtaacgaaaa
     1501 ttttttccta tcatttcttc tatgtagtat ttttcatttt ataattagtt ttttatttat
     1561 catagttact ctaagtatct atcatttatc tagtataaaa aattatctaa aaaattcacg
     1621 accacttaag ttaaatcttt gtatattaaa tatctgtcta ttcttaagca tgatccttct
     1681 gttaatagct tctacaaaag taataaatac ccataatgaa gccgaaaata attctcttaa
     1741 atattgggaa agaactacta atttatacaa aacaaatatt actaatcaat taaatagaaa
     1801 caacaccgta gaagaaaata actacttgaa aaaagctagt aaatttgttt ataaaataca
     1861 gaagaattat aaaactttta ttatcgcgcc atacaattac gcaactatcc aagagaataa
     1921 taaagaattt tttattggac aaaaagttta tccaaatttt gaagactatg ttagtcaacc
     1981 tgctggtgca ggaatatgtg ttgatttaaa ctatctaaaa tattacaatc ctatttcttt
     2041 tgaagaatct actgacttaa atttaataaa ctctgatcca ctaactactt acattctagt
     2101 acctaaaaaa tataaagaat atgcaaaaat gattgaaaaa aattatttag aagacataca
     2161 gtttagactt gaggactctc ctcctcaagc tccttataaa aatcctaatt tgaaaaattt
     2221 aaaaataaaa ctaatatttg ttaataataa ccaaaagtat tttagtttta ataccttata
     2281 tggaaaggca aaagataact atacaataac tgatcccata gttagagtta ttaatccaga
     2341 aataacagaa tcattatttt ggggaaatat attgactagt gatggtggat tattttttga
     2401 tcagaaacat acttcaaacc aaaacttttt taatcaaatt aatccgtata taaaagaatt
     2461 taacctagaa aatatcataa atttttctta ttctgttttt caagaaactg gtgaattatt
     2521 atctcaaaaa aaagtaaata aattaaatgc atatctacaa tatcttttaa tattaggatt
     2581 atttataata attaattttc aaatgatttt tgttagtttt actataaatt caaaaaaaat
     2641 agctttaaaa aaaatatttg gatattcacc aataagtcaa gttttagatt tatgtttact
     2701 cccttttaca atagagttat ttgctactat gtgttttcaa ttgatatttt caaaaaacac
     2761 ttacttgtat tttataattt ttatgatctt tttaataaat ctaattactt ctattattat
     2821 ttataaaaaa aatagtttta aatattttaa ggagaatatt ttatgatatt atcagttgag
     2881 aatttcaccc tgtcaattaa taaaaaaaag atcaaacaaa attggaactt ttcaatatca
     2941 gaaaaagatt ttattatagt aacaggaaaa agtggtagtg gaaaaactac tctgttaaat
     3001 aatttaagcc taatagataa acaatatacc ggtaacttat tctattttga aaagaaagtt
     3061 tctaaacatg atatacaacg tctacgaaga aatcatatta gctatttatt tcaaaactat
     3121 gctcttcttg aaaatcaaac agtacaatac aatttcgaat tagcaaaaaa gtttaacagt
     3181 aatatttcca atgatcatat ttataattta ttaacagatt tttctttgcc aaaagatatc
     3241 ttaaaagaaa aaatctttct cttaagcggt ggagaacaac aaagaatagc attaattaga
     3301 aatatgttaa aaccatttga tatattattt gcagatgaac ctacaggaaa tttagataaa
     3361 gaaaactcaa cttttataat gaactttctg aaaaatttaa cagaaaaaga aaaaaaagcc
     3421 gttgtactag taacacatga cttaaatgtt ctaaactatg gaactaatat tatagaatta
     3481 taatttttac ccgtgatgct agctgattta aaactagcac cacgggtatt tattttatat
     3541 tccatctctc ctatcccaaa atttaaataa tcacttaata aaaaggaggc acccaagtga
     3601 ttttattgaa aaaagagtat gaaaaatttt atgatagact tatttattct ttgcaattgc
     3661 caaaaaaatt aaaccgtcaa ttacaaaaga cttatgaaac taaatcaact gaagaatggg
     3721 agagttattg ctagattttt ggtagaagta acaaaaagtg gacatattat cataatgact
     3781 cgccgaaagt ctgataaaaa attggctaaa aatattgctg aatgtttaat aaaactatca
     3841 gttttagcta aatagttagt agtttacaca aaaaagcatt tatgtttttt gttgcaaagt
     3901 aacaatttca tcttcggtga aataagcgaa actttacaaa aagtggctag catttgctag
     3961 ctttttttgt attgtggagc gtggcttttg agggggattc aagggggagc ttgcgcccct
     4021 ttgacaagcg gttatttgca ctaaatacgt aggtatttgg ctagcaaata tagagcttgc
     4081 caaacccttt tagtgagctt tactcattgt acctttttag gtacaatggt attgcgaacg
     4141 atacgtccgt aggacgtact gaaagggtgg gacttatgag cgaacaaaat caaaatttgg
     4201 ctagcaattc ttctaaaaaa tatacctatc gatccgagcc aaaacaaatc agttttcgag
     4261 tgagcgaatc cgaatttgca aagctgaagc aatcggctga agctttgcaa atgagtgtgc
     4321 cggctttcgt gaaagccaag gcacaaaacg cgcgtctggt gacaccgaaa gtggcgccag
     4381 acattgccca ggcaatcgcg cgcgatttag ccaaagctgg agggaatatc aatcaaattg
     4441 ctaagtggtg caatacacac caacatgacg ttgcttctgg tgacgctcaa cgtttatccg
     4501 aaaacctaaa aatcatgcaa aaggagctac aaaagatatg gcaacaatta aggtaagccg
     4561 aaccacttct tgtagtcgtg caattaatta cgcagaacca cgagcaacca ttaaaacagg
     4621 aataaactgt gacgtcgatt atgccaaaag tgaaatgaaa caaattcgca tgctgtatgg
     4681 aaaagacgac cgtgtacagg cacacttatt gattcaatct tttcgaccag gagaaattac
     4741 cgctgaaaaa gctaatcaac taggggcaga gtatgcaaaa aaaatagccc ccgatcacca
     4801 aacagctatt tacacacata cagacaaaga ccatattcat aatcacattg tcattaactc
     4861 cgttaatctg gagactggaa aaaaatttca agctcatggt caagcatttc taaacaaatg
     4921 ttatgaccta aatgacgaga tttgtcttgc acataactta ccaatcactg agcgaggaaa
     4981 gaaaccagaa aaacgaacca tgtctgaaat aaaattaaaa gaaaaaaatg aacctgtttg
     5041 gaaagacgaa attcggattg cgatcgatca aacaatgaaa aacaaaaaaa ccagaaccta
     5101 tgaccaattt tgtaattccc tcaaaacatt ggggattcat tgcttcaatc gcgggaaaaa
     5161 tttcacttac gaattgatcc acaaaaagaa aaaagtacga tccaacagac taggaaagga
     5221 ctacgaaaag gagacgattt tacatgagct ggacagacga gaacgaacct ataaccaaca
     5281 gcgaaccaac gagctacgaa gagctcgagc tagcattcgc gaaactgcag aagaagtacg
     5341 aagagaacaa cgaactctta cgcctgaaca accggaaatt agaccggctc gaagaaacca
     5401 tgaacaacac gttgaaagag gaacagacca ccaacaagaa ttatcgctct aaaacgttaa
     5461 aagacataga aaacgaaata aagaaacaac gtgcttttct cgttccttat acgcaagaaa
     5521 ggatacaaac tacgattgat ttacaagtta aaaaactcca tcaagagcta ttagaccagc
     5581 gaaataagga acagaaaaag gtgcttattc aacgatcatt ggattttctt gcccccttat
     5641 gttgcttagt cctgacactg ttcgcatttt ggttagtatg gggagg
//
