LOCUS       NZ_CP121494.1          16348 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP121494.1 Staphylococcus epidermidis strain 24FSE03 plasmid
            unnamed1, complete sequence.
ACCESSION   NZ_CP121494
VERSION     NZ_CP121494.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-06-07 19:49:35
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 133
            Orig. end    :: 16481
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16348
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:15403]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..15403
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..16348
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16348
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             336..536
                     /locus_tag="ctg1_2"
                     /transl_table=11
                     /translation="MEHDPKIKMIVSAILFVMCLMILFYFIFFDPQFPVILCFSLLTFI
                     TGIDLYISYKKKKARDTNGNN"
     CDS             523..1533
                     /locus_tag="ctg1_3"
                     /transl_table=11
                     /translation="MATTKLSATKSTSRAINYAEKRAVEKSGLNCDVDYAKSSFKAARE
                     LYGKTDGNQGHVIIQSFQPGEVTPEQCNQLGLALAEKLVPNHQVAVYTHADTNHVHNHI
                     VLNSIDLNTGKKFNNNKQALRDVRAFNDEVCRAQGLSVPEKDTARLRYTQTEKAIADPN
                     TTSTAQYSWKDDIREAIDQSTATNMEEFQKHLNQHGITIERVTPKSITYRHLAENKKVR
                     GRKLGEDYNKGGIQHGFERQIQRRQQQKHKSDTNFQPKRSTSNRHESTERDTGVTQSDW
                     DQFAQDTNELERRRQAAESARLVDEKARRDREKRVREKPTSRPIINIDRDHGLEL"
     CDS             2886..3743
                     /locus_tag="ctg1_4"
                     /transl_table=11
                     /translation="MSGETVVYKNDMNLVPLRKFNNTEVNLFFTLCNKLKDKGNLTVNV
                     PFEELKELSNYYSHDKKLFIQDLEKFYDKVFSLTYREETENVIRKFILFTKVEIYKDKE
                     YVAIGVNPDLEHIINSLTSNFTKFELKEMTHLKSTYSKHMFRILKQYKHTGYVKIKIDD
                     FRERLDIPNSYRMTNINQKVLAPIIKELGFIFNNLNINKIKAKKGRKIEWLEFTFDAEK
                     RIHNKRQPQMANIDKSRQYISREKTPRWLEERTYEKQIKNEYDPQLEKERKAFLKQLQL
                     DWED"
     CDS             complement(3791..4402)
                     /locus_tag="ctg1_5"
                     /transl_table=11
                     /translation="MSMNKSKVAEIRKQKSLTQENLAEKAYVTVRTIQRMEAGEEVSSE
                     TLKSVSNALDVTVNELFESISSSDKEEEIMEISKEQQKQFNYRKNELFTIKLITFSFIF
                     VFLGLFGIFVGELNGLEQNIYRIIWIFALFLSLAIMYYFLNVFISKKLDKKYPMTIGMK
                     NRNRKNEPVKNGWDFMARYWWIVFPIGGFLSWLIPELTGK"
     CDS             4459..4656
                     /locus_tag="ctg1_6"
                     /transl_table=11
                     /translation="MKRQLLQNYILKRKYISNFTKSIRKDILKVTNSRYIIVCENPQRA
                     GWGFLFTYALVVIDKEHNQQ"
     CDS             complement(5001..7163)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 286.3; E-value:
                     8.2e-87)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_7"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.2e-38, bitscore:
                     122.3, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 5.7e-185, bitscore:
                     607.0, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVNALKFIKQYDESDCGPACLTMLAIYFGKNTMISRVREWSKTDK
                     EGTSLYGLIKGGEKLGINLTGVRADKISDIKKDELPVIAHIINEKGFMHFIIVEKVTDK
                     NLSILDPAKGKEKLSFAEFEKLWTGVLMLVQNDYTYGYDNDVPSKMKLFGRIIQNNKFI
                     IINILILSIIINLLGIAGAFYFKMLVDNIIPSQILKNLHILSIAILFLYIVNAFVSLIR
                     YQASLNLSLKIDMSFMKDYYKHVLNLPIKFYETRKSGEILSRFSDISYIREALSSVTIT
                     LLVDTLMIIIGGIILFTQSSKLFYITLVLIPLYLIIGLSFRKILEKYNRLVMEQDANLS
                     AYLIESFSGYPVIKSYVAENEVFKKGLTHFQKLIKRLYKLNLFTNIQLTLNSFMKMATT
                     LLILWMGSFLIMNNELSLGELLTFNALVIYYIAPIERLINLQPQIQSALVATQRYLDIT
                     DIKTEDEQRTNNKSKELDIHFKHQLELKNVSFKYNFKENVLKNINMNIPKNKKIAIIGE
                     SGSGKSTVAKLIDNFYIDYEGDIKIDNISVKDISKNSLRNIISFVTQKSFIFGATIKEN
                     LTIGINRKVSDTEINRACEIACADDFINELPQKINTQLHNGGSNLSGGQLQRIAIARAI
                     LRDTPILILDEATSSLDATIEKNILKNIEKFTESKTIILITHKLSNVTNADKIYLLKHG
                     EIIEQGTHTELVKEKKDYYNLWLNQF"
     CDS             7298..7471
                     /locus_tag="ctg1_8"
                     /transl_table=11
                     /translation="MKKLEIDTLKKIHGGSNDNLNGVKSWLGKQHDRLWESVGAGIAQQ
                     GNAEAWKHKTLG"
     CDS             7499..7669
                     /locus_tag="ctg1_9"
                     /transl_table=11
                     /translation="MKYEKLSNDELHNLNGGFWGYVISGATTVATDAWNHSDQIVKGAN
                     KESKKIAKQNK"
     CDS             complement(7742..7912)
                     /locus_tag="ctg1_10"
                     /transl_table=11
                     /translation="MSGIAEEMKPDKANNMPILESYNIVIKIARISKNIVIDLQILTIF
                     SFFVFIFVTSL"
     CDS             8212..8598
                     /locus_tag="ctg1_11"
                     /transl_table=11
                     /translation="MSEQNTFVASDETVGRNRKPNRKAPKQISFRVSESEYLKLQQSAE
                     TLNMSVPAFVKKKAQGARLVAPKLDQATRQSVAKDLSMLGANANQIAKYCNQHQHEAPN
                     YEALERNISELRERLDEIWNMIQK"
     CDS             8577..8777
                     /locus_tag="ctg1_12"
                     /transl_table=11
                     /translation="MEHDPKIKMIVSAILFVMCLMILFYFIFFDPQFPVILCFSLLTFI
                     TGIDLYISYKKKKARDTNGNN"
     CDS             8764..9774
                     /locus_tag="ctg1_13"
                     /transl_table=11
                     /translation="MATTKLSATKSTSRAINYAEKRAVEKSGLNCDVDYAKSSFKAARE
                     LYGKTDGNQGHVIIQSFQPGEVTPEQCNQLGLALAEKLVPNHQVAVYTHADTNHVHNHI
                     VLNSIDLNTGKKFNNNKQALRDVRAFNDEVCRAQGLSVPEKDTARLRYTQTEKAIADPN
                     TTSTAQYSWKDDIREAIDQSTATNMEEFQKHLNQHGITIERVTPKSITYRHLAENKKVR
                     GRKLGEDYNKGGIQHGFERQIQRRQQQKHKSDTNFQPKRSTSNRHESTERDTGVTQSDW
                     DQFAQDTNELERRRQAAESARLVDEKARRDREKRVREKPTSRPIINIDRDHGLEL"
     CDS             11127..11984
                     /locus_tag="ctg1_14"
                     /transl_table=11
                     /translation="MSGETVVYKNDMNLVPLRKFNNTEVNLFFTLCNKLKDKGNLTVNV
                     PFEELKELSNYYSHDKKLFIQDLEKFYDKVFSLTYREETENVIRKFILFTKVEIYKDKE
                     YVAIGVNPDLEHIINSLTSNFTKFELKEMTHLKSTYSKHMFRILKQYKHTGYVKIKIDD
                     FRERLDIPNSYRMTNINQKVLAPIIKELGFIFNNLNINKIKAKKGRKIEWLEFTFDAEK
                     RIHNKRQPQMANIDKSRQYISREKTPRWLEERTYEKQIKNEYDPQLEKERKAFLKQLQL
                     DWED"
     CDS             complement(12031..12642)
                     /locus_tag="ctg1_15"
                     /transl_table=11
                     /translation="MSMNKSKVAEIRKQKSLTQENLAEKAYVTVRTIQRMEAGEEVSSE
                     TLKSVSNALDVTVNELFESISSSDKEEEIMEISKEQQKQFNYRKNELFTIKLITFSFIF
                     VFLGLFGIFVGELNGLEQNIYRIIWIFALFLSLAIMYYFLNVFISKKLDKKYPMTIGMK
                     NRNRKNEPVKNGWDFMARYWWIVFPIGGFLSWLIPELTGK"
     CDS             12699..12896
                     /locus_tag="ctg1_16"
                     /transl_table=11
                     /translation="MKRQLLQNYILKRKYISNFTKSIRKDILKVTNSRYIIVCENPQRA
                     GWGFLFTYALVVIDKEHNQQ"
     CDS             complement(13241..15403)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 286.3; E-value:
                     8.2e-87)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_17"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.2e-38, bitscore:
                     122.3, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 5.7e-185, bitscore:
                     607.0, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVNALKFIKQYDESDCGPACLTMLAIYFGKNTMISRVREWSKTDK
                     EGTSLYGLIKGGEKLGINLTGVRADKISDIKKDELPVIAHIINEKGFMHFIIVEKVTDK
                     NLSILDPAKGKEKLSFAEFEKLWTGVLMLVQNDYTYGYDNDVPSKMKLFGRIIQNNKFI
                     IINILILSIIINLLGIAGAFYFKMLVDNIIPSQILKNLHILSIAILFLYIVNAFVSLIR
                     YQASLNLSLKIDMSFMKDYYKHVLNLPIKFYETRKSGEILSRFSDISYIREALSSVTIT
                     LLVDTLMIIIGGIILFTQSSKLFYITLVLIPLYLIIGLSFRKILEKYNRLVMEQDANLS
                     AYLIESFSGYPVIKSYVAENEVFKKGLTHFQKLIKRLYKLNLFTNIQLTLNSFMKMATT
                     LLILWMGSFLIMNNELSLGELLTFNALVIYYIAPIERLINLQPQIQSALVATQRYLDIT
                     DIKTEDEQRTNNKSKELDIHFKHQLELKNVSFKYNFKENVLKNINMNIPKNKKIAIIGE
                     SGSGKSTVAKLIDNFYIDYEGDIKIDNISVKDISKNSLRNIISFVTQKSFIFGATIKEN
                     LTIGINRKVSDTEINRACEIACADDFINELPQKINTQLHNGGSNLSGGQLQRIAIARAI
                     LRDTPILILDEATSSLDATIEKNILKNIEKFTESKTIILITHKLSNVTNADKIYLLKHG
                     EIIEQGTHTELVKEKKDYYNLWLNQF"
     CDS             15538..15711
                     /locus_tag="ctg1_18"
                     /transl_table=11
                     /translation="MKKLEIDTLKKIHGGSNDNLNGVKSWLGKQHDRLWESVGAGIAQQ
                     GNAEAWKHKTLG"
     CDS             15739..15909
                     /locus_tag="ctg1_19"
                     /transl_table=11
                     /translation="MKYEKLSNDELHNLNGGFWGYVISGATTVATDAWNHSDQIVKGAN
                     KESKKIAKQNK"
     CDS             complement(15982..16152)
                     /locus_tag="ctg1_20"
                     /transl_table=11
                     /translation="MSGIAEEMKPDKANNMPILESYNIVIKIARISKNIVIDLQILTIF
                     SFFVFIFVTSL"
ORIGIN
        1 gacgaaactg ttgggcgaaa ccgtaaaccc aaccgtaagg cgccgaaaca aattagtttt
       61 cgtgtgagcg aatccgaata tttaaagtta caacaatcag ctgaaacttt aaatatgagt
      121 gttcctgcgt tcgttaagaa aaaggcacaa ggcgcccgat tggtcgcacc caaattggat
      181 caagcaacgc gacaatcggt agctaaagat ttaagtatgt tgggtgcaaa tgccaatcag
      241 attgcgaaat attgcaacca acatcaacac gaagcaccga actacgaagc attagaacgt
      301 aacattagtg aattacgtga aaggttagat gagatatgga acatgatcca aaaataaaaa
      361 tgattgtaag tgccatttta tttgtgatgt gtttaatgat attgttttat tttattttct
      421 ttgatccaca atttccggtg attttgtgtt tttcactttt aacttttatc acaggtattg
      481 atttatatat atcatataaa aagaaaaaag cgcgtgatac caatggcaac aactaaatta
      541 agtgcgacta aatcaacatc acgggccatc aattacgctg aaaaacgtgc cgttgagaaa
      601 agtggcttaa attgtgacgt ggactatgcc aaatctagtt ttaaagccgc tcgtgaattg
      661 tatggcaaaa cagacggtaa tcaagggcat gtcattatcc aatcgtttca acctggcgaa
      721 gtgacgcccg aacaatgtaa ccaattagga ttagcgcttg ctgaaaaact cgtccccaat
      781 catcaagtcg ccgtctatac gcatgcagat acaaaccatg tacacaatca tattgtactt
      841 aattcaattg acctcaatac aggtaagaaa tttaacaata ataaacaagc cctacgcgat
      901 gtgagagcgt tcaacgacga ggtttgtcga gcacaggggt tgagcgtgcc tgagaaagac
      961 acagcacgct tacgttacac ccaaacagaa aaagcgattg ccgaccctaa cacgacgtcg
     1021 acagcacaat actcatggaa agatgacata cgtgaggcaa ttgaccaatc aacagcgaca
     1081 aatatggaag aatttcaaaa acatctgaat caacatggta ttacgattga acgtgttacc
     1141 cccaaaagca ttacctatcg gcatttagct gaaaataaaa aagtacgcgg gcgtaaattg
     1201 ggcgaagatt acaataaagg aggcatccaa catggctttg aaagacaaat acaacgacga
     1261 caacaacaaa aacataaatc agacacgaac ttccagccaa aacgatcaac ttcaaaccgt
     1321 catgaatcaa ctgaacgaga tacaggcgtc actcaatcag attgggacca attcgcccaa
     1381 gacacaaatg agcttgagcg tcgccgacaa gctgcagaat cagcaagact tgttgatgaa
     1441 aaggctcgaa gagatcgaga aaagagagta cgagagaaac caacgtcacg accaattatt
     1501 aacatcgatc gagaccacgg cctcgaactt taatcaagcc acagacttca cacaaaagcg
     1561 ttttataagc gcggcaagac attatattga acggattaat aacgataatt taaaacaaga
     1621 ttttcacaca gctatacaaa aagaattaga agatgtcaaa acagacacac aaaacgtagt
     1681 taaggaagtt caaaacaacc aatccgaact tcgacaagcc aataataatt ataaaaaaat
     1741 gattgatgaa cgtatgaaga gcaacgaaat agtgattaaa caatatgatc aagtcataca
     1801 tcgtttaact aaagggatta cagccatgtt ttttatcgtt gccttagtga tggtcgcctt
     1861 tttagttata agtcccttag gtgactggtt aggcgtccaa catttttacg aatggctgaa
     1921 ccacgtgctt aaaacggggc attcagcatg gcgttatttc atgcttgttt tctatcttgt
     1981 accttatatt ttatttggag tgcttatata tgccatttta aaagcatatg agcgtcttta
     2041 atacaaaata aatagaaaat taccttttgt ttaatgaaga agctatatca agcttaaaat
     2101 agcgtagaaa ccaaaaagga gtgctcgcct tgaattctat tgttcacttt atttgttttt
     2161 ttattgtatt ttgtcttttt ggatatgtgg tcaacttaat attttttgaa ggaacaaata
     2221 tttttctgat tttagaatca gcatttattt tatcattact aatcacaccg atattaaagg
     2281 ttgtaaaaga tatggaaaat gaagaatagc acatgcgctt atgccgagaa aatttattga
     2341 gcattgagaa gaacccttaa ttaaactgtt tcgacgaatg tcgggatagt gtgagctatg
     2401 aaaccgacga gtcgacagtt ttagggttta ttaagggttc agaggctcaa tgtcaataaa
     2461 gcaattggaa taatgcatta aagttatatc acttattact tttttaaata ataaaaaccc
     2521 accacaaatg tggtgggttt cctttttgtc ttttgaattt gtgaggggca aattgccccg
     2581 aactttttaa tatcttttta taaatctttt taaaaccttt ttaggagtca tttgatcctt
     2641 agagtgacaa tagatttgaa atgttaaagg caaccaatca ttaaactaaa ggcaaccaat
     2701 cattaaacta aaggcaacca atcattaaac taaaggcaac caatcattaa actaaagaaa
     2761 ctttttttat attaggtttc tttatgttat tattgtttat aacatagtga ttataagtat
     2821 ttacaattaa agttaatagg aatctttatt ctatataggt ttcttttaga ttggagtgga
     2881 gttagttgag tggagaaaca gtagtatata aaaatgatat gaatttagtt ccactgagaa
     2941 aatttaataa tactgaagtt aatctatttt ttactttgtg taataaatta aaagataaag
     3001 gcaatttgac tgttaatgtg ccatttgaag aattaaaaga attaagtaat tactatagtc
     3061 atgataaaaa gctttttatt caagatttag aaaaattcta tgacaaagtt ttctctttaa
     3121 catatagaga agaaactgag aatgttatta gaaaatttat tctttttact aaagtagaaa
     3181 tttataaaga taaagagtat gtggctattg gtgttaatcc agatttagaa catattatta
     3241 attcattaac tagtaacttc actaaatttg aacttaaaga aatgacacac cttaaatcta
     3301 catattctaa gcatatgttc agaatactta agcagtataa acatactggc tatgtaaaaa
     3361 ttaaaattga tgattttaga gaacggctgg atattcctaa tagttaccgt atgacaaata
     3421 ttaatcaaaa agtattagcc cctatcatta aagaattagg ctttattttt aataacctta
     3481 atatcaataa aataaaggca aaaaaaggac gtaaaattga atggttagag tttacttttg
     3541 acgctgagaa acgcattcac aataaacgac agccacaaat ggcgaatata gataagtcac
     3601 gacaatatat aagtcgggaa aaaacgccga gatggttaga agaacgtact tatgaaaaac
     3661 aaataaaaaa tgaatatgat ccacaattag aaaaagagcg aaaagcattt ttaaaacaac
     3721 ttcaattaga ctgggaagat taaaacaaaa gatctttagc ccccttgcta aagatctttt
     3781 gttttgtatt ttattttcct gttaattcag gaattagcca acttagaaac cctccaatag
     3841 gaaaaacaat ccaccaatat ctagccataa aatcccagcc attttttaca ggttcatttt
     3901 ttctatttct atttttcatt ccaatagtca taggatattt tttatctaat ttttttgaaa
     3961 taaaaacatt taaaaaataa tacattattg ctaagctcaa aaataaagcg aaaatccaaa
     4021 tgatgcggta aatattttgt tctaaaccgt ttaactcacc tacaaagatt ccaaatagtc
     4081 ctaaaaacac aaaaataaaa ctaaatgtta ttaatttaat agtaaaaagt tcatttttac
     4141 gataattaaa ctgcttttgt tgttctttag atatttccat tatttcctcc tccttatcag
     4201 aagacgagat agattcgaat agttcattga ctgtcacatc taatgcgttt gagacacttt
     4261 taagtgtttc actactaact tcttctccag cctccattct ttgaattgtt cttactgtta
     4321 cataagcctt ttctgctaaa ttttcttgag ttaacgattt ttgttttcta atttctgcaa
     4381 cttttgattt gttcatactc ataaactact cctcaactaa aaaaatgaac acgaaaaatt
     4441 gccgacagat gggcgacaat gaaacgacag ttacttcaaa attatattct taaaagaaag
     4501 tatatatcta attttacaaa aagcataaga aaggatatac tgaaagtaac aaatagcaga
     4561 tatatcattg tatgtgaaaa cccccagcgt gccggctggg ggtttctttt tacttatgct
     4621 cttgttgtaa tagataaaga acataaccaa caataattgg aaaaatgagc ttatctagta
     4681 caaatagcaa gattatcatt gtatgtgaca cctcctttgt gcacggaagt gcttttccag
     4741 tataacaaaa aactacaatt taaaacggtg tgttatcacg tgaaattgtg aataaagata
     4801 caaaagttca cttaatgaaa aagaatgaaa acacgtgaga acaacgatgt ataaaagatg
     4861 aataaacgat aatcacaaga caaaggctta aacgttgatt taacagcgtt taagccttta
     4921 ttgttagttg acataattat gtattatagg tagttgaatt gtatagttta tacaatagat
     4981 taaatctaag aatataataa ttaaaattga tttagccaca aattatagta atcttttttt
     5041 tcttttacta attctgtatg agttccttgt tcaattattt caccatgctt aagtaaatat
     5101 attttatctg catttgtaac attacttaat ttatgtgtaa ttaatataat tgttttactt
     5161 tcagtgaatt tctcaatatt ttttaaaata tttttttcaa ttgtagcatc taaagaacta
     5221 gttgcttcgt ctaaaataag tataggagta tctcgaagta tagctcttgc tattgctatt
     5281 ctttgcaatt gaccacctga taaatttgat ccaccattat gcaattgagt atttattttt
     5341 tgtggtaatt catttataaa atcatcagca caggctattt cacaagctcg atttatttca
     5401 gtatcagaaa ctttcctatt tataccaatt gttaaatttt ctttaattgt agctccaaaa
     5461 ataaaacttt tctgtgttac aaaactaatt atgtttctca aggagttttt tgatatatct
     5521 ttcactgaaa tattatcaat ttttatatct ccttcataat caatataaaa attatcaatc
     5581 aatttagcca cagttgattt accagaacca ctttcaccaa taattgctat ttttttattt
     5641 tttggaatat tcatatttat atttttcaaa acattttctt taaaattata cttaaaactt
     5701 acgtttttta actctaattg gtgtttaaaa tgaatatcta attctttaga tttattatta
     5761 gttctttgtt cgtcctctgt tttaatatca gtaatatcta aatatctttg cgtagctaca
     5821 agagctgatt gtatttgtgg ttgtaagtta attaaacgct ctataggtgc aatataatat
     5881 ataactagag cattaaatgt taacagttca cctaatgata attcattatt catgattaaa
     5941 aaggaaccca tccacaaaat tagtaaagta gttgccattt tcataaaact atttagagta
     6001 agttgaatat ttgtaaataa atttaattta tataatcttt ttattaactt ttgaaagtga
     6061 gttaaaccct ttttaaaaac ttcattttca gctacataac tttttattac tggataaccc
     6121 gaaaaacttt caatgagata ggcacttaaa ttggcatctt gttccattac aagcctatta
     6181 tacttttcta aaatttttct aaaagataaa ccaataatta aatataacgg aataagaact
     6241 aaagtaatat aaaataattt agaactttgt gtaaataaaa taatacctcc gattataatc
     6301 atcaatgtat ctacaagtaa tgtaatagta actgaagaaa gtgcttctct tatgtatgaa
     6361 atgtcagaaa atcttgaaag aatttcacca ctttttcttg tttcataaaa cttaatgggt
     6421 aaatttaaaa catgcttata ataatctttc ataaaactca tatcaatttt caaacttaaa
     6481 tttaaagagg cttgatatct tattaatgat acaaaagcat ttactatata aagaaataaa
     6541 atcgctatag ataaaatatg taaatttttt aaaatttgcg aaggaataat attatcaact
     6601 agcattttaa aataaaaagc tccagcaatt cctaataaat ttataattat agatagtatt
     6661 aatatattta tgattataaa tttattattt tgaattattc taccaaataa tttcatttta
     6721 ctggggacat cattatcata accatatgta taatcatttt gaactagcat aagtacacca
     6781 gtccacaatt tttcaaattc agcaaaagaa agtttttctt ttccttttgc tggatcaaga
     6841 atagataaat ttttatctgt cactttttcc actattataa aatgcatgaa gcctttttca
     6901 tttataatat gtgctataac tggtaattca tcttttttaa tatctgatat tttatctgct
     6961 cttactccag taaggttaat acctaatttt tctccacctt ttataagtcc atataacgat
     7021 gtgccttctt tatctgtttt agaccattct cttacccttg aaatcattgt attttttcca
     7081 aaatatatag ctagcatagt taaacacgct ggtccacaat cactttcatc atattgttta
     7141 ataaatttca aagcattcac cacctacata ttattaatag aattatattt gaaaaatgat
     7201 aaatcgtaaa actaagtctt tatttttaag tagcttgaaa aatcagaaaa tattgttaaa
     7261 atgaatttgt aaacggtttt aaaggaggtt taataatatg aaaaaattag aaattgatac
     7321 tcttaaaaaa atccatggtg gttccaatga caatttaaat ggtgttaaaa gctggcttgg
     7381 taagcaacac gatagactat gggaatctgt aggagctggc attgctcaac aaggtaatgc
     7441 agaagcttgg aaacacaaga cattaggata aaaatagtta aagtaaggag ttataataat
     7501 gaaatatgaa aaattatcaa atgacgaatt acacaatcta aatggtggct tttggggata
     7561 tgtaatatca ggagcgacaa cagttgcaac agatgcatgg aaccattcag accaaattgt
     7621 aaaaggcgca aataaagaat ctaaaaaaat agcaaaacaa aataaataga taaatatatt
     7681 atcataaaac cccttacttt tcgaaaagta aggggtttta tgataatata tttataaact
     7741 tctataagct ggtgacaaaa atgaaaacaa aaaatgaaaa tattgtaagt atttgtagat
     7801 ctataacaat atttttacta attctagcaa ttttaataac tatattatac gattctaaaa
     7861 tcggcatatt atttgcttta tcaggtttca tttcttctgc aataccagac atatataaca
     7921 aaaagaaaat aggttggttc tttttaatcc tttctcttat attaataatt ctatttttta
     7981 tttaagagaa atttgaactt gagtggctag caattagcca ctattttttc atcagaaaaa
     8041 atccataagg ggcttgggga gtatccccaa caagctggcg cgtctgccac gtaagtggct
     8101 agcaaagcca atgcttgcca aaccacttaa cgacttgatg aatcttactt tatcatataa
     8161 agtaagatgt aagaacggcg ttatctttcg aagaaagcgt ggtgggattg aatgagcgaa
     8221 caaaacacat ttgtggctag cgacgaaact gttgggcgaa accgtaaacc caaccgtaag
     8281 gcgccgaaac aaattagttt tcgtgtgagc gaatccgaat atttaaagtt acaacaatca
     8341 gctgaaactt taaatatgag tgttcctgcg ttcgttaaga aaaaggcaca aggcgcccga
     8401 ttggtcgcac ccaaattgga tcaagcaacg cgacaatcgg tagctaaaga tttaagtatg
     8461 ttgggtgcaa atgccaatca gattgcgaaa tattgcaacc aacatcaaca cgaagcaccg
     8521 aactacgaag cattagaacg taacattagt gaattacgtg aaaggttaga tgagatatgg
     8581 aacatgatcc aaaaataaaa atgattgtaa gtgccatttt atttgtgatg tgtttaatga
     8641 tattgtttta ttttattttc tttgatccac aatttccggt gattttgtgt ttttcacttt
     8701 taacttttat cacaggtatt gatttatata tatcatataa aaagaaaaaa gcgcgtgata
     8761 ccaatggcaa caactaaatt aagtgcgact aaatcaacat cacgggccat caattacgct
     8821 gaaaaacgtg ccgttgagaa aagtggctta aattgtgacg tggactatgc caaatctagt
     8881 tttaaagccg ctcgtgaatt gtatggcaaa acagacggta atcaagggca tgtcattatc
     8941 caatcgtttc aacctggcga agtgacgccc gaacaatgta accaattagg attagcgctt
     9001 gctgaaaaac tcgtccccaa tcatcaagtc gccgtctata cgcatgcaga tacaaaccat
     9061 gtacacaatc atattgtact taattcaatt gacctcaata caggtaagaa atttaacaat
     9121 aataaacaag ccctacgcga tgtgagagcg ttcaacgacg aggtttgtcg agcacagggg
     9181 ttgagcgtgc ctgagaaaga cacagcacgc ttacgttaca cccaaacaga aaaagcgatt
     9241 gccgacccta acacgacgtc gacagcacaa tactcatgga aagatgacat acgtgaggca
     9301 attgaccaat caacagcgac aaatatggaa gaatttcaaa aacatctgaa tcaacatggt
     9361 attacgattg aacgtgttac ccccaaaagc attacctatc ggcatttagc tgaaaataaa
     9421 aaagtacgcg ggcgtaaatt gggcgaagat tacaataaag gaggcatcca acatggcttt
     9481 gaaagacaaa tacaacgacg acaacaacaa aaacataaat cagacacgaa cttccagcca
     9541 aaacgatcaa cttcaaaccg tcatgaatca actgaacgag atacaggcgt cactcaatca
     9601 gattgggacc aattcgccca agacacaaat gagcttgagc gtcgccgaca agctgcagaa
     9661 tcagcaagac ttgttgatga aaaggctcga agagatcgag aaaagagagt acgagagaaa
     9721 ccaacgtcac gaccaattat taacatcgat cgagaccacg gcctcgaact ttaatcaagc
     9781 cacagacttc acacaaaagc gttttataag cgcggcaaga cattatattg aacggattaa
     9841 taacgataat ttaaaacaag attttcacac agctatacaa aaagaattag aagatgtcaa
     9901 aacagacaca caaaacgtag ttaaggaagt tcaaaacaac caatccgaac ttcgacaagc
     9961 caataataat tataaaaaaa tgattgatga acgtatgaag agcaacgaaa tagtgattaa
    10021 acaatatgat caagtcatac atcgtttaac taaagggatt acagccatgt tttttatcgt
    10081 tgccttagtg atggtcgcct ttttagttat aagtccctta ggtgactggt taggcgtcca
    10141 acatttttac gaatggctga accacgtgct taaaacgggg cattcagcat ggcgttattt
    10201 catgcttgtt ttctatcttg taccttatat tttatttgga gtgcttatat atgccatttt
    10261 aaaagcatat gagcgtcttt aatacaaaat aaatagaaaa ttaccttttg tttaatgaag
    10321 aagctatatc aagcttaaaa tagcgtagaa accaaaaagg agtgctcgcc ttgaattcta
    10381 ttgttcactt tatttgtttt tttattgtat tttgtctttt tggatatgtg gtcaacttaa
    10441 tattttttga aggaacaaat atttttctga ttttagaatc agcatttatt ttatcattac
    10501 taatcacacc gatattaaag gttgtaaaag atatggaaaa tgaagaatag cacatgcgct
    10561 tatgccgaga aaatttattg agcattgaga agaaccctta attaaactgt ttcgacgaat
    10621 gtcgggatag tgtgagctat gaaaccgacg agtcgacagt tttagggttt attaagggtt
    10681 cagaggctca atgtcaataa agcaattgga ataatgcatt aaagttatat cacttattac
    10741 ttttttaaat aataaaaacc caccacaaat gtggtgggtt tcctttttgt cttttgaatt
    10801 tgtgaggggc aaattgcccc gaacttttta atatcttttt ataaatcttt ttaaaacctt
    10861 tttaggagtc atttgatcct tagagtgaca atagatttga aatgttaaag gcaaccaatc
    10921 attaaactaa aggcaaccaa tcattaaact aaaggcaacc aatcattaaa ctaaaggcaa
    10981 ccaatcatta aactaaagaa acttttttta tattaggttt ctttatgtta ttattgttta
    11041 taacatagtg attataagta tttacaatta aagttaatag gaatctttat tctatatagg
    11101 tttcttttag attggagtgg agttagttga gtggagaaac agtagtatat aaaaatgata
    11161 tgaatttagt tccactgaga aaatttaata atactgaagt taatctattt tttactttgt
    11221 gtaataaatt aaaagataaa ggcaatttga ctgttaatgt gccatttgaa gaattaaaag
    11281 aattaagtaa ttactatagt catgataaaa agctttttat tcaagattta gaaaaattct
    11341 atgacaaagt tttctcttta acatatagag aagaaactga gaatgttatt agaaaattta
    11401 ttctttttac taaagtagaa atttataaag ataaagagta tgtggctatt ggtgttaatc
    11461 cagatttaga acatattatt aattcattaa ctagtaactt cactaaattt gaacttaaag
    11521 aaatgacaca ccttaaatct acatattcta agcatatgtt cagaatactt aagcagtata
    11581 aacatactgg ctatgtaaaa attaaaattg atgattttag agaacggctg gatattccta
    11641 atagttaccg tatgacaaat attaatcaaa aagtattagc ccctatcatt aaagaattag
    11701 gctttatttt taataacctt aatatcaata aaataaaggc aaaaaaagga cgtaaaattg
    11761 aatggttaga gtttactttt gacgctgaga aacgcattca caataaacga cagccacaaa
    11821 tggcgaatat agataagtca cgacaatata taagtcggga aaaaacgccg agatggttag
    11881 aagaacgtac ttatgaaaaa caaataaaaa atgaatatga tccacaatta gaaaaagagc
    11941 gaaaagcatt tttaaaacaa cttcaattag actgggaaga ttaaaacaaa agatctttag
    12001 ccccttgcta aagatctttt gttttgtatt ttattttcct gttaattcag gaattagcca
    12061 acttagaaac cctccaatag gaaaaacaat ccaccaatat ctagccataa aatcccagcc
    12121 attttttaca ggttcatttt ttctatttct atttttcatt ccaatagtca taggatattt
    12181 tttatctaat ttttttgaaa taaaaacatt taaaaaataa tacattattg ctaagctcaa
    12241 aaataaagcg aaaatccaaa tgatgcggta aatattttgt tctaaaccgt ttaactcacc
    12301 tacaaagatt ccaaatagtc ctaaaaacac aaaaataaaa ctaaatgtta ttaatttaat
    12361 agtaaaaagt tcatttttac gataattaaa ctgcttttgt tgttctttag atatttccat
    12421 tatttcctcc tccttatcag aagacgagat agattcgaat agttcattga ctgtcacatc
    12481 taatgcgttt gagacacttt taagtgtttc actactaact tcttctccag cctccattct
    12541 ttgaattgtt cttactgtta cataagcctt ttctgctaaa ttttcttgag ttaacgattt
    12601 ttgttttcta atttctgcaa cttttgattt gttcatactc ataaactact cctcaactaa
    12661 aaaaatgaac acgaaaaatt gccgacagat gggcgacaat gaaacgacag ttacttcaaa
    12721 attatattct taaaagaaag tatatatcta attttacaaa aagcataaga aaggatatac
    12781 tgaaagtaac aaatagcaga tatatcattg tatgtgaaaa cccccagcgt gccggctggg
    12841 ggtttctttt tacttatgct cttgttgtaa tagataaaga acataaccaa caataattgg
    12901 aaaaatgagc ttatctagta caaatagcaa gattatcatt gtatgtgaca cctcctttgt
    12961 gcacggaagt gcttttccag tataacaaaa aactacaatt taaaacggtg tgttatcacg
    13021 tgaaattgtg aataaagata caaaagttca cttaatgaaa aagaatgaaa acacgtgaga
    13081 acaacgatgt ataaaagatg aataaacgat aatcacaaga caaaggctta aacgttgatt
    13141 taacagcgtt taagccttta ttgttagttg acataattat gtattatagg tagttgaatt
    13201 gtatagttta tacaatagat taaatctaag aatataataa ttaaaattga tttagccaca
    13261 aattatagta atcttttttt tcttttacta attctgtatg agttccttgt tcaattattt
    13321 caccatgctt aagtaaatat attttatctg catttgtaac attacttaat ttatgtgtaa
    13381 ttaatataat tgttttactt tcagtgaatt tctcaatatt ttttaaaata tttttttcaa
    13441 ttgtagcatc taaagaacta gttgcttcgt ctaaaataag tataggagta tctcgaagta
    13501 tagctcttgc tattgctatt ctttgcaatt gaccacctga taaatttgat ccaccattat
    13561 gcaattgagt atttattttt tgtggtaatt catttataaa atcatcagca caggctattt
    13621 cacaagctcg atttatttca gtatcagaaa ctttcctatt tataccaatt gttaaatttt
    13681 ctttaattgt agctccaaaa ataaaacttt tctgtgttac aaaactaatt atgtttctca
    13741 aggagttttt tgatatatct ttcactgaaa tattatcaat ttttatatct ccttcataat
    13801 caatataaaa attatcaatc aatttagcca cagttgattt accagaacca ctttcaccaa
    13861 taattgctat ttttttattt tttggaatat tcatatttat atttttcaaa acattttctt
    13921 taaaattata cttaaaactt acgtttttta actctaattg gtgtttaaaa tgaatatcta
    13981 attctttaga tttattatta gttctttgtt cgtcctctgt tttaatatca gtaatatcta
    14041 aatatctttg cgtagctaca agagctgatt gtatttgtgg ttgtaagtta attaaacgct
    14101 ctataggtgc aatataatat ataactagag cattaaatgt taacagttca cctaatgata
    14161 attcattatt catgattaaa aaggaaccca tccacaaaat tagtaaagta gttgccattt
    14221 tcataaaact atttagagta agttgaatat ttgtaaataa atttaattta tataatcttt
    14281 ttattaactt ttgaaagtga gttaaaccct ttttaaaaac ttcattttca gctacataac
    14341 tttttattac tggataaccc gaaaaacttt caatgagata ggcacttaaa ttggcatctt
    14401 gttccattac aagcctatta tacttttcta aaatttttct aaaagataaa ccaataatta
    14461 aatataacgg aataagaact aaagtaatat aaaataattt agaactttgt gtaaataaaa
    14521 taatacctcc gattataatc atcaatgtat ctacaagtaa tgtaatagta actgaagaaa
    14581 gtgcttctct tatgtatgaa atgtcagaaa atcttgaaag aatttcacca ctttttcttg
    14641 tttcataaaa cttaatgggt aaatttaaaa catgcttata ataatctttc ataaaactca
    14701 tatcaatttt caaacttaaa tttaaagagg cttgatatct tattaatgat acaaaagcat
    14761 ttactatata aagaaataaa atcgctatag ataaaatatg taaatttttt aaaatttgcg
    14821 aaggaataat attatcaact agcattttaa aataaaaagc tccagcaatt cctaataaat
    14881 ttataattat agatagtatt aatatattta tgattataaa tttattattt tgaattattc
    14941 taccaaataa tttcatttta ctggggacat cattatcata accatatgta taatcatttt
    15001 gaactagcat aagtacacca gtccacaatt tttcaaattc agcaaaagaa agtttttctt
    15061 ttccttttgc tggatcaaga atagataaat ttttatctgt cactttttcc actattataa
    15121 aatgcatgaa gcctttttca tttataatat gtgctataac tggtaattca tcttttttaa
    15181 tatctgatat tttatctgct cttactccag taaggttaat acctaatttt tctccacctt
    15241 ttataagtcc atataacgat gtgccttctt tatctgtttt agaccattct cttacccttg
    15301 aaatcattgt attttttcca aaatatatag ctagcatagt taaacacgct ggtccacaat
    15361 cactttcatc atattgttta ataaatttca aagcattcac cacctacata ttattaatag
    15421 aattatattt gaaaaatgat aaatcgtaaa actaagtctt tatttttaag tagcttgaaa
    15481 aatcagaaaa tattgttaaa atgaatttgt aaacggtttt aaaggaggtt taataatatg
    15541 aaaaaattag aaattgatac tcttaaaaaa atccatggtg gttccaatga caatttaaat
    15601 ggtgttaaaa gctggcttgg taagcaacac gatagactat gggaatctgt aggagctggc
    15661 attgctcaac aaggtaatgc agaagcttgg aaacacaaga cattaggata aaaatagtta
    15721 aagtaaggag ttataataat gaaatatgaa aaattatcaa atgacgaatt acacaatcta
    15781 aatggtggct tttggggata tgtaatatca ggagcgacaa cagttgcaac agatgcatgg
    15841 aaccattcag accaaattgt aaaaggcgca aataaagaat ctaaaaaaat agcaaaacaa
    15901 aataaataga taaatatatt atcataaaac cccttacttt tcgaaaagta aggggtttta
    15961 tgataatata tttataaact tctataagct ggtgacaaaa atgaaaacaa aaaatgaaaa
    16021 tattgtaagt atttgtagat ctataacaat atttttacta attctagcaa ttttaataac
    16081 tatattatac gattctaaaa tcggcatatt atttgcttta tcaggtttca tttcttctgc
    16141 aataccagac atatataaca aaaagaaaat aggttggttc tttttaatcc tttctcttat
    16201 attaataatt ctatttttta tttaagagaa atttgaactt gagtggctag caattagcca
    16261 ctattttttc atcagaaaaa atccataagg ggcttgggga gtatccccaa caagctggcg
    16321 cgtctgccac gtaagtggct agcaaagc
//
