LOCUS       NZ_CP121494.1          16481 bp    DNA              UNK 01-JAN-1980
DEFINITION  NZ_CP121494.1 Staphylococcus epidermidis strain 24FSE03 plasmid
            unnamed1, complete sequence.
ACCESSION   NZ_CP121494
VERSION     NZ_CP121494.1
KEYWORDS    .
SOURCE      .
  ORGANISM  .
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-06-07 19:49:35
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             104..490
                     /locus_tag="ctg1_1"
                     /transl_table=11
                     /translation="MSEQNTFVASDETVGRNRKPNRKAPKQISFRVSESEYLKLQQSAE
                     TLNMSVPAFVKKKAQGARLVAPKLDQATRQSVAKDLSMLGANANQIAKYCNQHQHEAPN
                     YEALERNISELRERLDEIWNMIQK"
     protocluster    134..16481
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5133:15536]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5134..15536
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    134..16481
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          134..16481
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             469..669
                     /locus_tag="ctg1_2"
                     /transl_table=11
                     /translation="MEHDPKIKMIVSAILFVMCLMILFYFIFFDPQFPVILCFSLLTFI
                     TGIDLYISYKKKKARDTNGNN"
     CDS             656..1666
                     /locus_tag="ctg1_3"
                     /transl_table=11
                     /translation="MATTKLSATKSTSRAINYAEKRAVEKSGLNCDVDYAKSSFKAARE
                     LYGKTDGNQGHVIIQSFQPGEVTPEQCNQLGLALAEKLVPNHQVAVYTHADTNHVHNHI
                     VLNSIDLNTGKKFNNNKQALRDVRAFNDEVCRAQGLSVPEKDTARLRYTQTEKAIADPN
                     TTSTAQYSWKDDIREAIDQSTATNMEEFQKHLNQHGITIERVTPKSITYRHLAENKKVR
                     GRKLGEDYNKGGIQHGFERQIQRRQQQKHKSDTNFQPKRSTSNRHESTERDTGVTQSDW
                     DQFAQDTNELERRRQAAESARLVDEKARRDREKRVREKPTSRPIINIDRDHGLEL"
     CDS             3019..3876
                     /locus_tag="ctg1_4"
                     /transl_table=11
                     /translation="MSGETVVYKNDMNLVPLRKFNNTEVNLFFTLCNKLKDKGNLTVNV
                     PFEELKELSNYYSHDKKLFIQDLEKFYDKVFSLTYREETENVIRKFILFTKVEIYKDKE
                     YVAIGVNPDLEHIINSLTSNFTKFELKEMTHLKSTYSKHMFRILKQYKHTGYVKIKIDD
                     FRERLDIPNSYRMTNINQKVLAPIIKELGFIFNNLNINKIKAKKGRKIEWLEFTFDAEK
                     RIHNKRQPQMANIDKSRQYISREKTPRWLEERTYEKQIKNEYDPQLEKERKAFLKQLQL
                     DWED"
     CDS             complement(3924..4535)
                     /locus_tag="ctg1_5"
                     /transl_table=11
                     /translation="MSMNKSKVAEIRKQKSLTQENLAEKAYVTVRTIQRMEAGEEVSSE
                     TLKSVSNALDVTVNELFESISSSDKEEEIMEISKEQQKQFNYRKNELFTIKLITFSFIF
                     VFLGLFGIFVGELNGLEQNIYRIIWIFALFLSLAIMYYFLNVFISKKLDKKYPMTIGMK
                     NRNRKNEPVKNGWDFMARYWWIVFPIGGFLSWLIPELTGK"
     CDS             4592..4789
                     /locus_tag="ctg1_6"
                     /transl_table=11
                     /translation="MKRQLLQNYILKRKYISNFTKSIRKDILKVTNSRYIIVCENPQRA
                     GWGFLFTYALVVIDKEHNQQ"
     CDS             complement(5134..7296)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 286.3; E-value:
                     8.2e-87)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_7"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.2e-38, bitscore:
                     122.3, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 5.7e-185, bitscore:
                     607.0, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVNALKFIKQYDESDCGPACLTMLAIYFGKNTMISRVREWSKTDK
                     EGTSLYGLIKGGEKLGINLTGVRADKISDIKKDELPVIAHIINEKGFMHFIIVEKVTDK
                     NLSILDPAKGKEKLSFAEFEKLWTGVLMLVQNDYTYGYDNDVPSKMKLFGRIIQNNKFI
                     IINILILSIIINLLGIAGAFYFKMLVDNIIPSQILKNLHILSIAILFLYIVNAFVSLIR
                     YQASLNLSLKIDMSFMKDYYKHVLNLPIKFYETRKSGEILSRFSDISYIREALSSVTIT
                     LLVDTLMIIIGGIILFTQSSKLFYITLVLIPLYLIIGLSFRKILEKYNRLVMEQDANLS
                     AYLIESFSGYPVIKSYVAENEVFKKGLTHFQKLIKRLYKLNLFTNIQLTLNSFMKMATT
                     LLILWMGSFLIMNNELSLGELLTFNALVIYYIAPIERLINLQPQIQSALVATQRYLDIT
                     DIKTEDEQRTNNKSKELDIHFKHQLELKNVSFKYNFKENVLKNINMNIPKNKKIAIIGE
                     SGSGKSTVAKLIDNFYIDYEGDIKIDNISVKDISKNSLRNIISFVTQKSFIFGATIKEN
                     LTIGINRKVSDTEINRACEIACADDFINELPQKINTQLHNGGSNLSGGQLQRIAIARAI
                     LRDTPILILDEATSSLDATIEKNILKNIEKFTESKTIILITHKLSNVTNADKIYLLKHG
                     EIIEQGTHTELVKEKKDYYNLWLNQF"
     CDS             7431..7604
                     /locus_tag="ctg1_8"
                     /transl_table=11
                     /translation="MKKLEIDTLKKIHGGSNDNLNGVKSWLGKQHDRLWESVGAGIAQQ
                     GNAEAWKHKTLG"
     CDS             7632..7802
                     /locus_tag="ctg1_9"
                     /transl_table=11
                     /translation="MKYEKLSNDELHNLNGGFWGYVISGATTVATDAWNHSDQIVKGAN
                     KESKKIAKQNK"
     CDS             complement(7875..8045)
                     /locus_tag="ctg1_10"
                     /transl_table=11
                     /translation="MSGIAEEMKPDKANNMPILESYNIVIKIARISKNIVIDLQILTIF
                     SFFVFIFVTSL"
     CDS             8345..8731
                     /locus_tag="ctg1_11"
                     /transl_table=11
                     /translation="MSEQNTFVASDETVGRNRKPNRKAPKQISFRVSESEYLKLQQSAE
                     TLNMSVPAFVKKKAQGARLVAPKLDQATRQSVAKDLSMLGANANQIAKYCNQHQHEAPN
                     YEALERNISELRERLDEIWNMIQK"
     CDS             8710..8910
                     /locus_tag="ctg1_12"
                     /transl_table=11
                     /translation="MEHDPKIKMIVSAILFVMCLMILFYFIFFDPQFPVILCFSLLTFI
                     TGIDLYISYKKKKARDTNGNN"
     CDS             8897..9907
                     /locus_tag="ctg1_13"
                     /transl_table=11
                     /translation="MATTKLSATKSTSRAINYAEKRAVEKSGLNCDVDYAKSSFKAARE
                     LYGKTDGNQGHVIIQSFQPGEVTPEQCNQLGLALAEKLVPNHQVAVYTHADTNHVHNHI
                     VLNSIDLNTGKKFNNNKQALRDVRAFNDEVCRAQGLSVPEKDTARLRYTQTEKAIADPN
                     TTSTAQYSWKDDIREAIDQSTATNMEEFQKHLNQHGITIERVTPKSITYRHLAENKKVR
                     GRKLGEDYNKGGIQHGFERQIQRRQQQKHKSDTNFQPKRSTSNRHESTERDTGVTQSDW
                     DQFAQDTNELERRRQAAESARLVDEKARRDREKRVREKPTSRPIINIDRDHGLEL"
     CDS             11260..12117
                     /locus_tag="ctg1_14"
                     /transl_table=11
                     /translation="MSGETVVYKNDMNLVPLRKFNNTEVNLFFTLCNKLKDKGNLTVNV
                     PFEELKELSNYYSHDKKLFIQDLEKFYDKVFSLTYREETENVIRKFILFTKVEIYKDKE
                     YVAIGVNPDLEHIINSLTSNFTKFELKEMTHLKSTYSKHMFRILKQYKHTGYVKIKIDD
                     FRERLDIPNSYRMTNINQKVLAPIIKELGFIFNNLNINKIKAKKGRKIEWLEFTFDAEK
                     RIHNKRQPQMANIDKSRQYISREKTPRWLEERTYEKQIKNEYDPQLEKERKAFLKQLQL
                     DWED"
     CDS             complement(12164..12775)
                     /locus_tag="ctg1_15"
                     /transl_table=11
                     /translation="MSMNKSKVAEIRKQKSLTQENLAEKAYVTVRTIQRMEAGEEVSSE
                     TLKSVSNALDVTVNELFESISSSDKEEEIMEISKEQQKQFNYRKNELFTIKLITFSFIF
                     VFLGLFGIFVGELNGLEQNIYRIIWIFALFLSLAIMYYFLNVFISKKLDKKYPMTIGMK
                     NRNRKNEPVKNGWDFMARYWWIVFPIGGFLSWLIPELTGK"
     CDS             12832..13029
                     /locus_tag="ctg1_16"
                     /transl_table=11
                     /translation="MKRQLLQNYILKRKYISNFTKSIRKDILKVTNSRYIIVCENPQRA
                     GWGFLFTYALVVIDKEHNQQ"
     CDS             complement(13374..15536)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 286.3; E-value:
                     8.2e-87)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_17"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.2e-38, bitscore:
                     122.3, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 5.7e-185, bitscore:
                     607.0, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVNALKFIKQYDESDCGPACLTMLAIYFGKNTMISRVREWSKTDK
                     EGTSLYGLIKGGEKLGINLTGVRADKISDIKKDELPVIAHIINEKGFMHFIIVEKVTDK
                     NLSILDPAKGKEKLSFAEFEKLWTGVLMLVQNDYTYGYDNDVPSKMKLFGRIIQNNKFI
                     IINILILSIIINLLGIAGAFYFKMLVDNIIPSQILKNLHILSIAILFLYIVNAFVSLIR
                     YQASLNLSLKIDMSFMKDYYKHVLNLPIKFYETRKSGEILSRFSDISYIREALSSVTIT
                     LLVDTLMIIIGGIILFTQSSKLFYITLVLIPLYLIIGLSFRKILEKYNRLVMEQDANLS
                     AYLIESFSGYPVIKSYVAENEVFKKGLTHFQKLIKRLYKLNLFTNIQLTLNSFMKMATT
                     LLILWMGSFLIMNNELSLGELLTFNALVIYYIAPIERLINLQPQIQSALVATQRYLDIT
                     DIKTEDEQRTNNKSKELDIHFKHQLELKNVSFKYNFKENVLKNINMNIPKNKKIAIIGE
                     SGSGKSTVAKLIDNFYIDYEGDIKIDNISVKDISKNSLRNIISFVTQKSFIFGATIKEN
                     LTIGINRKVSDTEINRACEIACADDFINELPQKINTQLHNGGSNLSGGQLQRIAIARAI
                     LRDTPILILDEATSSLDATIEKNILKNIEKFTESKTIILITHKLSNVTNADKIYLLKHG
                     EIIEQGTHTELVKEKKDYYNLWLNQF"
     CDS             15671..15844
                     /locus_tag="ctg1_18"
                     /transl_table=11
                     /translation="MKKLEIDTLKKIHGGSNDNLNGVKSWLGKQHDRLWESVGAGIAQQ
                     GNAEAWKHKTLG"
     CDS             15872..16042
                     /locus_tag="ctg1_19"
                     /transl_table=11
                     /translation="MKYEKLSNDELHNLNGGFWGYVISGATTVATDAWNHSDQIVKGAN
                     KESKKIAKQNK"
     CDS             complement(16115..16285)
                     /locus_tag="ctg1_20"
                     /transl_table=11
                     /translation="MSGIAEEMKPDKANNMPILESYNIVIKIARISKNIVIDLQILTIF
                     SFFVFIFVTSL"
ORIGIN
        1 caatgcttgc caaaccactt aacgacttga tgaatcttac tttatcatat aaagtaagat
       61 gtaagaacgg cgttatcttt cgaagaaagc gtggtgggat tgaatgagcg aacaaaacac
      121 atttgtggct agcgacgaaa ctgttgggcg aaaccgtaaa cccaaccgta aggcgccgaa
      181 acaaattagt tttcgtgtga gcgaatccga atatttaaag ttacaacaat cagctgaaac
      241 tttaaatatg agtgttcctg cgttcgttaa gaaaaaggca caaggcgccc gattggtcgc
      301 acccaaattg gatcaagcaa cgcgacaatc ggtagctaaa gatttaagta tgttgggtgc
      361 aaatgccaat cagattgcga aatattgcaa ccaacatcaa cacgaagcac cgaactacga
      421 agcattagaa cgtaacatta gtgaattacg tgaaaggtta gatgagatat ggaacatgat
      481 ccaaaaataa aaatgattgt aagtgccatt ttatttgtga tgtgtttaat gatattgttt
      541 tattttattt tctttgatcc acaatttccg gtgattttgt gtttttcact tttaactttt
      601 atcacaggta ttgatttata tatatcatat aaaaagaaaa aagcgcgtga taccaatggc
      661 aacaactaaa ttaagtgcga ctaaatcaac atcacgggcc atcaattacg ctgaaaaacg
      721 tgccgttgag aaaagtggct taaattgtga cgtggactat gccaaatcta gttttaaagc
      781 cgctcgtgaa ttgtatggca aaacagacgg taatcaaggg catgtcatta tccaatcgtt
      841 tcaacctggc gaagtgacgc ccgaacaatg taaccaatta ggattagcgc ttgctgaaaa
      901 actcgtcccc aatcatcaag tcgccgtcta tacgcatgca gatacaaacc atgtacacaa
      961 tcatattgta cttaattcaa ttgacctcaa tacaggtaag aaatttaaca ataataaaca
     1021 agccctacgc gatgtgagag cgttcaacga cgaggtttgt cgagcacagg ggttgagcgt
     1081 gcctgagaaa gacacagcac gcttacgtta cacccaaaca gaaaaagcga ttgccgaccc
     1141 taacacgacg tcgacagcac aatactcatg gaaagatgac atacgtgagg caattgacca
     1201 atcaacagcg acaaatatgg aagaatttca aaaacatctg aatcaacatg gtattacgat
     1261 tgaacgtgtt acccccaaaa gcattaccta tcggcattta gctgaaaata aaaaagtacg
     1321 cgggcgtaaa ttgggcgaag attacaataa aggaggcatc caacatggct ttgaaagaca
     1381 aatacaacga cgacaacaac aaaaacataa atcagacacg aacttccagc caaaacgatc
     1441 aacttcaaac cgtcatgaat caactgaacg agatacaggc gtcactcaat cagattggga
     1501 ccaattcgcc caagacacaa atgagcttga gcgtcgccga caagctgcag aatcagcaag
     1561 acttgttgat gaaaaggctc gaagagatcg agaaaagaga gtacgagaga aaccaacgtc
     1621 acgaccaatt attaacatcg atcgagacca cggcctcgaa ctttaatcaa gccacagact
     1681 tcacacaaaa gcgttttata agcgcggcaa gacattatat tgaacggatt aataacgata
     1741 atttaaaaca agattttcac acagctatac aaaaagaatt agaagatgtc aaaacagaca
     1801 cacaaaacgt agttaaggaa gttcaaaaca accaatccga acttcgacaa gccaataata
     1861 attataaaaa aatgattgat gaacgtatga agagcaacga aatagtgatt aaacaatatg
     1921 atcaagtcat acatcgttta actaaaggga ttacagccat gttttttatc gttgccttag
     1981 tgatggtcgc ctttttagtt ataagtccct taggtgactg gttaggcgtc caacattttt
     2041 acgaatggct gaaccacgtg cttaaaacgg ggcattcagc atggcgttat ttcatgcttg
     2101 ttttctatct tgtaccttat attttatttg gagtgcttat atatgccatt ttaaaagcat
     2161 atgagcgtct ttaatacaaa ataaatagaa aattaccttt tgtttaatga agaagctata
     2221 tcaagcttaa aatagcgtag aaaccaaaaa ggagtgctcg ccttgaattc tattgttcac
     2281 tttatttgtt tttttattgt attttgtctt tttggatatg tggtcaactt aatatttttt
     2341 gaaggaacaa atatttttct gattttagaa tcagcattta ttttatcatt actaatcaca
     2401 ccgatattaa aggttgtaaa agatatggaa aatgaagaat agcacatgcg cttatgccga
     2461 gaaaatttat tgagcattga gaagaaccct taattaaact gtttcgacga atgtcgggat
     2521 agtgtgagct atgaaaccga cgagtcgaca gttttagggt ttattaaggg ttcagaggct
     2581 caatgtcaat aaagcaattg gaataatgca ttaaagttat atcacttatt acttttttaa
     2641 ataataaaaa cccaccacaa atgtggtggg tttccttttt gtcttttgaa tttgtgaggg
     2701 gcaaattgcc ccgaactttt taatatcttt ttataaatct ttttaaaacc tttttaggag
     2761 tcatttgatc cttagagtga caatagattt gaaatgttaa aggcaaccaa tcattaaact
     2821 aaaggcaacc aatcattaaa ctaaaggcaa ccaatcatta aactaaaggc aaccaatcat
     2881 taaactaaag aaactttttt tatattaggt ttctttatgt tattattgtt tataacatag
     2941 tgattataag tatttacaat taaagttaat aggaatcttt attctatata ggtttctttt
     3001 agattggagt ggagttagtt gagtggagaa acagtagtat ataaaaatga tatgaattta
     3061 gttccactga gaaaatttaa taatactgaa gttaatctat tttttacttt gtgtaataaa
     3121 ttaaaagata aaggcaattt gactgttaat gtgccatttg aagaattaaa agaattaagt
     3181 aattactata gtcatgataa aaagcttttt attcaagatt tagaaaaatt ctatgacaaa
     3241 gttttctctt taacatatag agaagaaact gagaatgtta ttagaaaatt tattcttttt
     3301 actaaagtag aaatttataa agataaagag tatgtggcta ttggtgttaa tccagattta
     3361 gaacatatta ttaattcatt aactagtaac ttcactaaat ttgaacttaa agaaatgaca
     3421 caccttaaat ctacatattc taagcatatg ttcagaatac ttaagcagta taaacatact
     3481 ggctatgtaa aaattaaaat tgatgatttt agagaacggc tggatattcc taatagttac
     3541 cgtatgacaa atattaatca aaaagtatta gcccctatca ttaaagaatt aggctttatt
     3601 tttaataacc ttaatatcaa taaaataaag gcaaaaaaag gacgtaaaat tgaatggtta
     3661 gagtttactt ttgacgctga gaaacgcatt cacaataaac gacagccaca aatggcgaat
     3721 atagataagt cacgacaata tataagtcgg gaaaaaacgc cgagatggtt agaagaacgt
     3781 acttatgaaa aacaaataaa aaatgaatat gatccacaat tagaaaaaga gcgaaaagca
     3841 tttttaaaac aacttcaatt agactgggaa gattaaaaca aaagatcttt agcccccttg
     3901 ctaaagatct tttgttttgt attttatttt cctgttaatt caggaattag ccaacttaga
     3961 aaccctccaa taggaaaaac aatccaccaa tatctagcca taaaatccca gccatttttt
     4021 acaggttcat tttttctatt tctatttttc attccaatag tcataggata ttttttatct
     4081 aatttttttg aaataaaaac atttaaaaaa taatacatta ttgctaagct caaaaataaa
     4141 gcgaaaatcc aaatgatgcg gtaaatattt tgttctaaac cgtttaactc acctacaaag
     4201 attccaaata gtcctaaaaa cacaaaaata aaactaaatg ttattaattt aatagtaaaa
     4261 agttcatttt tacgataatt aaactgcttt tgttgttctt tagatatttc cattatttcc
     4321 tcctccttat cagaagacga gatagattcg aatagttcat tgactgtcac atctaatgcg
     4381 tttgagacac ttttaagtgt ttcactacta acttcttctc cagcctccat tctttgaatt
     4441 gttcttactg ttacataagc cttttctgct aaattttctt gagttaacga tttttgtttt
     4501 ctaatttctg caacttttga tttgttcata ctcataaact actcctcaac taaaaaaatg
     4561 aacacgaaaa attgccgaca gatgggcgac aatgaaacga cagttacttc aaaattatat
     4621 tcttaaaaga aagtatatat ctaattttac aaaaagcata agaaaggata tactgaaagt
     4681 aacaaatagc agatatatca ttgtatgtga aaacccccag cgtgccggct gggggtttct
     4741 ttttacttat gctcttgttg taatagataa agaacataac caacaataat tggaaaaatg
     4801 agcttatcta gtacaaatag caagattatc attgtatgtg acacctcctt tgtgcacgga
     4861 agtgcttttc cagtataaca aaaaactaca atttaaaacg gtgtgttatc acgtgaaatt
     4921 gtgaataaag atacaaaagt tcacttaatg aaaaagaatg aaaacacgtg agaacaacga
     4981 tgtataaaag atgaataaac gataatcaca agacaaaggc ttaaacgttg atttaacagc
     5041 gtttaagcct ttattgttag ttgacataat tatgtattat aggtagttga attgtatagt
     5101 ttatacaata gattaaatct aagaatataa taattaaaat tgatttagcc acaaattata
     5161 gtaatctttt ttttctttta ctaattctgt atgagttcct tgttcaatta tttcaccatg
     5221 cttaagtaaa tatattttat ctgcatttgt aacattactt aatttatgtg taattaatat
     5281 aattgtttta ctttcagtga atttctcaat attttttaaa atattttttt caattgtagc
     5341 atctaaagaa ctagttgctt cgtctaaaat aagtatagga gtatctcgaa gtatagctct
     5401 tgctattgct attctttgca attgaccacc tgataaattt gatccaccat tatgcaattg
     5461 agtatttatt ttttgtggta attcatttat aaaatcatca gcacaggcta tttcacaagc
     5521 tcgatttatt tcagtatcag aaactttcct atttatacca attgttaaat tttctttaat
     5581 tgtagctcca aaaataaaac ttttctgtgt tacaaaacta attatgtttc tcaaggagtt
     5641 ttttgatata tctttcactg aaatattatc aatttttata tctccttcat aatcaatata
     5701 aaaattatca atcaatttag ccacagttga tttaccagaa ccactttcac caataattgc
     5761 tattttttta ttttttggaa tattcatatt tatatttttc aaaacatttt ctttaaaatt
     5821 atacttaaaa cttacgtttt ttaactctaa ttggtgttta aaatgaatat ctaattcttt
     5881 agatttatta ttagttcttt gttcgtcctc tgttttaata tcagtaatat ctaaatatct
     5941 ttgcgtagct acaagagctg attgtatttg tggttgtaag ttaattaaac gctctatagg
     6001 tgcaatataa tatataacta gagcattaaa tgttaacagt tcacctaatg ataattcatt
     6061 attcatgatt aaaaaggaac ccatccacaa aattagtaaa gtagttgcca ttttcataaa
     6121 actatttaga gtaagttgaa tatttgtaaa taaatttaat ttatataatc tttttattaa
     6181 cttttgaaag tgagttaaac cctttttaaa aacttcattt tcagctacat aactttttat
     6241 tactggataa cccgaaaaac tttcaatgag ataggcactt aaattggcat cttgttccat
     6301 tacaagccta ttatactttt ctaaaatttt tctaaaagat aaaccaataa ttaaatataa
     6361 cggaataaga actaaagtaa tataaaataa tttagaactt tgtgtaaata aaataatacc
     6421 tccgattata atcatcaatg tatctacaag taatgtaata gtaactgaag aaagtgcttc
     6481 tcttatgtat gaaatgtcag aaaatcttga aagaatttca ccactttttc ttgtttcata
     6541 aaacttaatg ggtaaattta aaacatgctt ataataatct ttcataaaac tcatatcaat
     6601 tttcaaactt aaatttaaag aggcttgata tcttattaat gatacaaaag catttactat
     6661 ataaagaaat aaaatcgcta tagataaaat atgtaaattt tttaaaattt gcgaaggaat
     6721 aatattatca actagcattt taaaataaaa agctccagca attcctaata aatttataat
     6781 tatagatagt attaatatat ttatgattat aaatttatta ttttgaatta ttctaccaaa
     6841 taatttcatt ttactgggga catcattatc ataaccatat gtataatcat tttgaactag
     6901 cataagtaca ccagtccaca atttttcaaa ttcagcaaaa gaaagttttt cttttccttt
     6961 tgctggatca agaatagata aatttttatc tgtcactttt tccactatta taaaatgcat
     7021 gaagcctttt tcatttataa tatgtgctat aactggtaat tcatcttttt taatatctga
     7081 tattttatct gctcttactc cagtaaggtt aatacctaat ttttctccac cttttataag
     7141 tccatataac gatgtgcctt ctttatctgt tttagaccat tctcttaccc ttgaaatcat
     7201 tgtatttttt ccaaaatata tagctagcat agttaaacac gctggtccac aatcactttc
     7261 atcatattgt ttaataaatt tcaaagcatt caccacctac atattattaa tagaattata
     7321 tttgaaaaat gataaatcgt aaaactaagt ctttattttt aagtagcttg aaaaatcaga
     7381 aaatattgtt aaaatgaatt tgtaaacggt tttaaaggag gtttaataat atgaaaaaat
     7441 tagaaattga tactcttaaa aaaatccatg gtggttccaa tgacaattta aatggtgtta
     7501 aaagctggct tggtaagcaa cacgatagac tatgggaatc tgtaggagct ggcattgctc
     7561 aacaaggtaa tgcagaagct tggaaacaca agacattagg ataaaaatag ttaaagtaag
     7621 gagttataat aatgaaatat gaaaaattat caaatgacga attacacaat ctaaatggtg
     7681 gcttttgggg atatgtaata tcaggagcga caacagttgc aacagatgca tggaaccatt
     7741 cagaccaaat tgtaaaaggc gcaaataaag aatctaaaaa aatagcaaaa caaaataaat
     7801 agataaatat attatcataa aaccccttac ttttcgaaaa gtaaggggtt ttatgataat
     7861 atatttataa acttctataa gctggtgaca aaaatgaaaa caaaaaatga aaatattgta
     7921 agtatttgta gatctataac aatattttta ctaattctag caattttaat aactatatta
     7981 tacgattcta aaatcggcat attatttgct ttatcaggtt tcatttcttc tgcaatacca
     8041 gacatatata acaaaaagaa aataggttgg ttctttttaa tcctttctct tatattaata
     8101 attctatttt ttatttaaga gaaatttgaa cttgagtggc tagcaattag ccactatttt
     8161 ttcatcagaa aaaatccata aggggcttgg ggagtatccc caacaagctg gcgcgtctgc
     8221 cacgtaagtg gctagcaaag ccaatgcttg ccaaaccact taacgacttg atgaatctta
     8281 ctttatcata taaagtaaga tgtaagaacg gcgttatctt tcgaagaaag cgtggtggga
     8341 ttgaatgagc gaacaaaaca catttgtggc tagcgacgaa actgttgggc gaaaccgtaa
     8401 acccaaccgt aaggcgccga aacaaattag ttttcgtgtg agcgaatccg aatatttaaa
     8461 gttacaacaa tcagctgaaa ctttaaatat gagtgttcct gcgttcgtta agaaaaaggc
     8521 acaaggcgcc cgattggtcg cacccaaatt ggatcaagca acgcgacaat cggtagctaa
     8581 agatttaagt atgttgggtg caaatgccaa tcagattgcg aaatattgca accaacatca
     8641 acacgaagca ccgaactacg aagcattaga acgtaacatt agtgaattac gtgaaaggtt
     8701 agatgagata tggaacatga tccaaaaata aaaatgattg taagtgccat tttatttgtg
     8761 atgtgtttaa tgatattgtt ttattttatt ttctttgatc cacaatttcc ggtgattttg
     8821 tgtttttcac ttttaacttt tatcacaggt attgatttat atatatcata taaaaagaaa
     8881 aaagcgcgtg ataccaatgg caacaactaa attaagtgcg actaaatcaa catcacgggc
     8941 catcaattac gctgaaaaac gtgccgttga gaaaagtggc ttaaattgtg acgtggacta
     9001 tgccaaatct agttttaaag ccgctcgtga attgtatggc aaaacagacg gtaatcaagg
     9061 gcatgtcatt atccaatcgt ttcaacctgg cgaagtgacg cccgaacaat gtaaccaatt
     9121 aggattagcg cttgctgaaa aactcgtccc caatcatcaa gtcgccgtct atacgcatgc
     9181 agatacaaac catgtacaca atcatattgt acttaattca attgacctca atacaggtaa
     9241 gaaatttaac aataataaac aagccctacg cgatgtgaga gcgttcaacg acgaggtttg
     9301 tcgagcacag gggttgagcg tgcctgagaa agacacagca cgcttacgtt acacccaaac
     9361 agaaaaagcg attgccgacc ctaacacgac gtcgacagca caatactcat ggaaagatga
     9421 catacgtgag gcaattgacc aatcaacagc gacaaatatg gaagaatttc aaaaacatct
     9481 gaatcaacat ggtattacga ttgaacgtgt tacccccaaa agcattacct atcggcattt
     9541 agctgaaaat aaaaaagtac gcgggcgtaa attgggcgaa gattacaata aaggaggcat
     9601 ccaacatggc tttgaaagac aaatacaacg acgacaacaa caaaaacata aatcagacac
     9661 gaacttccag ccaaaacgat caacttcaaa ccgtcatgaa tcaactgaac gagatacagg
     9721 cgtcactcaa tcagattggg accaattcgc ccaagacaca aatgagcttg agcgtcgccg
     9781 acaagctgca gaatcagcaa gacttgttga tgaaaaggct cgaagagatc gagaaaagag
     9841 agtacgagag aaaccaacgt cacgaccaat tattaacatc gatcgagacc acggcctcga
     9901 actttaatca agccacagac ttcacacaaa agcgttttat aagcgcggca agacattata
     9961 ttgaacggat taataacgat aatttaaaac aagattttca cacagctata caaaaagaat
    10021 tagaagatgt caaaacagac acacaaaacg tagttaagga agttcaaaac aaccaatccg
    10081 aacttcgaca agccaataat aattataaaa aaatgattga tgaacgtatg aagagcaacg
    10141 aaatagtgat taaacaatat gatcaagtca tacatcgttt aactaaaggg attacagcca
    10201 tgttttttat cgttgcctta gtgatggtcg cctttttagt tataagtccc ttaggtgact
    10261 ggttaggcgt ccaacatttt tacgaatggc tgaaccacgt gcttaaaacg gggcattcag
    10321 catggcgtta tttcatgctt gttttctatc ttgtacctta tattttattt ggagtgctta
    10381 tatatgccat tttaaaagca tatgagcgtc tttaatacaa aataaataga aaattacctt
    10441 ttgtttaatg aagaagctat atcaagctta aaatagcgta gaaaccaaaa aggagtgctc
    10501 gccttgaatt ctattgttca ctttatttgt ttttttattg tattttgtct ttttggatat
    10561 gtggtcaact taatattttt tgaaggaaca aatatttttc tgattttaga atcagcattt
    10621 attttatcat tactaatcac accgatatta aaggttgtaa aagatatgga aaatgaagaa
    10681 tagcacatgc gcttatgccg agaaaattta ttgagcattg agaagaaccc ttaattaaac
    10741 tgtttcgacg aatgtcggga tagtgtgagc tatgaaaccg acgagtcgac agttttaggg
    10801 tttattaagg gttcagaggc tcaatgtcaa taaagcaatt ggaataatgc attaaagtta
    10861 tatcacttat tactttttta aataataaaa acccaccaca aatgtggtgg gtttcctttt
    10921 tgtcttttga atttgtgagg ggcaaattgc cccgaacttt ttaatatctt tttataaatc
    10981 tttttaaaac ctttttagga gtcatttgat ccttagagtg acaatagatt tgaaatgtta
    11041 aaggcaacca atcattaaac taaaggcaac caatcattaa actaaaggca accaatcatt
    11101 aaactaaagg caaccaatca ttaaactaaa gaaacttttt ttatattagg tttctttatg
    11161 ttattattgt ttataacata gtgattataa gtatttacaa ttaaagttaa taggaatctt
    11221 tattctatat aggtttcttt tagattggag tggagttagt tgagtggaga aacagtagta
    11281 tataaaaatg atatgaattt agttccactg agaaaattta ataatactga agttaatcta
    11341 ttttttactt tgtgtaataa attaaaagat aaaggcaatt tgactgttaa tgtgccattt
    11401 gaagaattaa aagaattaag taattactat agtcatgata aaaagctttt tattcaagat
    11461 ttagaaaaat tctatgacaa agttttctct ttaacatata gagaagaaac tgagaatgtt
    11521 attagaaaat ttattctttt tactaaagta gaaatttata aagataaaga gtatgtggct
    11581 attggtgtta atccagattt agaacatatt attaattcat taactagtaa cttcactaaa
    11641 tttgaactta aagaaatgac acaccttaaa tctacatatt ctaagcatat gttcagaata
    11701 cttaagcagt ataaacatac tggctatgta aaaattaaaa ttgatgattt tagagaacgg
    11761 ctggatattc ctaatagtta ccgtatgaca aatattaatc aaaaagtatt agcccctatc
    11821 attaaagaat taggctttat ttttaataac cttaatatca ataaaataaa ggcaaaaaaa
    11881 ggacgtaaaa ttgaatggtt agagtttact tttgacgctg agaaacgcat tcacaataaa
    11941 cgacagccac aaatggcgaa tatagataag tcacgacaat atataagtcg ggaaaaaacg
    12001 ccgagatggt tagaagaacg tacttatgaa aaacaaataa aaaatgaata tgatccacaa
    12061 ttagaaaaag agcgaaaagc atttttaaaa caacttcaat tagactggga agattaaaac
    12121 aaaagatctt tagccccttg ctaaagatct tttgttttgt attttatttt cctgttaatt
    12181 caggaattag ccaacttaga aaccctccaa taggaaaaac aatccaccaa tatctagcca
    12241 taaaatccca gccatttttt acaggttcat tttttctatt tctatttttc attccaatag
    12301 tcataggata ttttttatct aatttttttg aaataaaaac atttaaaaaa taatacatta
    12361 ttgctaagct caaaaataaa gcgaaaatcc aaatgatgcg gtaaatattt tgttctaaac
    12421 cgtttaactc acctacaaag attccaaata gtcctaaaaa cacaaaaata aaactaaatg
    12481 ttattaattt aatagtaaaa agttcatttt tacgataatt aaactgcttt tgttgttctt
    12541 tagatatttc cattatttcc tcctccttat cagaagacga gatagattcg aatagttcat
    12601 tgactgtcac atctaatgcg tttgagacac ttttaagtgt ttcactacta acttcttctc
    12661 cagcctccat tctttgaatt gttcttactg ttacataagc cttttctgct aaattttctt
    12721 gagttaacga tttttgtttt ctaatttctg caacttttga tttgttcata ctcataaact
    12781 actcctcaac taaaaaaatg aacacgaaaa attgccgaca gatgggcgac aatgaaacga
    12841 cagttacttc aaaattatat tcttaaaaga aagtatatat ctaattttac aaaaagcata
    12901 agaaaggata tactgaaagt aacaaatagc agatatatca ttgtatgtga aaacccccag
    12961 cgtgccggct gggggtttct ttttacttat gctcttgttg taatagataa agaacataac
    13021 caacaataat tggaaaaatg agcttatcta gtacaaatag caagattatc attgtatgtg
    13081 acacctcctt tgtgcacgga agtgcttttc cagtataaca aaaaactaca atttaaaacg
    13141 gtgtgttatc acgtgaaatt gtgaataaag atacaaaagt tcacttaatg aaaaagaatg
    13201 aaaacacgtg agaacaacga tgtataaaag atgaataaac gataatcaca agacaaaggc
    13261 ttaaacgttg atttaacagc gtttaagcct ttattgttag ttgacataat tatgtattat
    13321 aggtagttga attgtatagt ttatacaata gattaaatct aagaatataa taattaaaat
    13381 tgatttagcc acaaattata gtaatctttt ttttctttta ctaattctgt atgagttcct
    13441 tgttcaatta tttcaccatg cttaagtaaa tatattttat ctgcatttgt aacattactt
    13501 aatttatgtg taattaatat aattgtttta ctttcagtga atttctcaat attttttaaa
    13561 atattttttt caattgtagc atctaaagaa ctagttgctt cgtctaaaat aagtatagga
    13621 gtatctcgaa gtatagctct tgctattgct attctttgca attgaccacc tgataaattt
    13681 gatccaccat tatgcaattg agtatttatt ttttgtggta attcatttat aaaatcatca
    13741 gcacaggcta tttcacaagc tcgatttatt tcagtatcag aaactttcct atttatacca
    13801 attgttaaat tttctttaat tgtagctcca aaaataaaac ttttctgtgt tacaaaacta
    13861 attatgtttc tcaaggagtt ttttgatata tctttcactg aaatattatc aatttttata
    13921 tctccttcat aatcaatata aaaattatca atcaatttag ccacagttga tttaccagaa
    13981 ccactttcac caataattgc tattttttta ttttttggaa tattcatatt tatatttttc
    14041 aaaacatttt ctttaaaatt atacttaaaa cttacgtttt ttaactctaa ttggtgttta
    14101 aaatgaatat ctaattcttt agatttatta ttagttcttt gttcgtcctc tgttttaata
    14161 tcagtaatat ctaaatatct ttgcgtagct acaagagctg attgtatttg tggttgtaag
    14221 ttaattaaac gctctatagg tgcaatataa tatataacta gagcattaaa tgttaacagt
    14281 tcacctaatg ataattcatt attcatgatt aaaaaggaac ccatccacaa aattagtaaa
    14341 gtagttgcca ttttcataaa actatttaga gtaagttgaa tatttgtaaa taaatttaat
    14401 ttatataatc tttttattaa cttttgaaag tgagttaaac cctttttaaa aacttcattt
    14461 tcagctacat aactttttat tactggataa cccgaaaaac tttcaatgag ataggcactt
    14521 aaattggcat cttgttccat tacaagccta ttatactttt ctaaaatttt tctaaaagat
    14581 aaaccaataa ttaaatataa cggaataaga actaaagtaa tataaaataa tttagaactt
    14641 tgtgtaaata aaataatacc tccgattata atcatcaatg tatctacaag taatgtaata
    14701 gtaactgaag aaagtgcttc tcttatgtat gaaatgtcag aaaatcttga aagaatttca
    14761 ccactttttc ttgtttcata aaacttaatg ggtaaattta aaacatgctt ataataatct
    14821 ttcataaaac tcatatcaat tttcaaactt aaatttaaag aggcttgata tcttattaat
    14881 gatacaaaag catttactat ataaagaaat aaaatcgcta tagataaaat atgtaaattt
    14941 tttaaaattt gcgaaggaat aatattatca actagcattt taaaataaaa agctccagca
    15001 attcctaata aatttataat tatagatagt attaatatat ttatgattat aaatttatta
    15061 ttttgaatta ttctaccaaa taatttcatt ttactgggga catcattatc ataaccatat
    15121 gtataatcat tttgaactag cataagtaca ccagtccaca atttttcaaa ttcagcaaaa
    15181 gaaagttttt cttttccttt tgctggatca agaatagata aatttttatc tgtcactttt
    15241 tccactatta taaaatgcat gaagcctttt tcatttataa tatgtgctat aactggtaat
    15301 tcatcttttt taatatctga tattttatct gctcttactc cagtaaggtt aatacctaat
    15361 ttttctccac cttttataag tccatataac gatgtgcctt ctttatctgt tttagaccat
    15421 tctcttaccc ttgaaatcat tgtatttttt ccaaaatata tagctagcat agttaaacac
    15481 gctggtccac aatcactttc atcatattgt ttaataaatt tcaaagcatt caccacctac
    15541 atattattaa tagaattata tttgaaaaat gataaatcgt aaaactaagt ctttattttt
    15601 aagtagcttg aaaaatcaga aaatattgtt aaaatgaatt tgtaaacggt tttaaaggag
    15661 gtttaataat atgaaaaaat tagaaattga tactcttaaa aaaatccatg gtggttccaa
    15721 tgacaattta aatggtgtta aaagctggct tggtaagcaa cacgatagac tatgggaatc
    15781 tgtaggagct ggcattgctc aacaaggtaa tgcagaagct tggaaacaca agacattagg
    15841 ataaaaatag ttaaagtaag gagttataat aatgaaatat gaaaaattat caaatgacga
    15901 attacacaat ctaaatggtg gcttttgggg atatgtaata tcaggagcga caacagttgc
    15961 aacagatgca tggaaccatt cagaccaaat tgtaaaaggc gcaaataaag aatctaaaaa
    16021 aatagcaaaa caaaataaat agataaatat attatcataa aaccccttac ttttcgaaaa
    16081 gtaaggggtt ttatgataat atatttataa acttctataa gctggtgaca aaaatgaaaa
    16141 caaaaaatga aaatattgta agtatttgta gatctataac aatattttta ctaattctag
    16201 caattttaat aactatatta tacgattcta aaatcggcat attatttgct ttatcaggtt
    16261 tcatttcttc tgcaatacca gacatatata acaaaaagaa aataggttgg ttctttttaa
    16321 tcctttctct tatattaata attctatttt ttatttaaga gaaatttgaa cttgagtggc
    16381 tagcaattag ccactatttt ttcatcagaa aaaatccata aggggcttgg ggagtatccc
    16441 caacaagctg gcgcgtctgc cacgtaagtg gctagcaaag c
//
