LOCUS       NZ_CP093223.1          18102 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP093223.1 Staphylococcus epidermidis strain CICARIA plasmid
            unnamed2, complete sequence.
ACCESSION   NZ_CP093223
VERSION     NZ_CP093223.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-06-07 23:11:00
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 18102
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..18102
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5543:8102]"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5544..8102
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     cand_cluster    1..18102
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..18102
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-iii"
                     /region_number="1"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     CDS             455..1396
                     /locus_tag="ctg1_1"
                     /transl_table=11
                     /translation="MSNFKRITIQEFEQERFYKLYKFLFEDDYFRKLSDSAKIAYCMFR
                     DRFELSKMNNWIDDNGNVYLIFTTKDLCELLNCGTQKVTKIKKELENFNLLEQERMGLN
                     KPNKIYILEPKKTSKTDDSKEFRKSKFQNNENQNSRVLKVKKQEFRKSKSNDTEFNNTD
                     YIETDYNDLNDLNDTNNNISTTNNHSNHSNYQKNKFNNDALKFQVLEELPNQIKDYLSN
                     FEIREIRIIKSVLLKGKKSFNNTQDTYYRLEDVEFELVNVLKRFKAMLLQKNETVEAMQ
                     GYLMQSIKAELEEIHTLNMRRQNMPKYNIFNE"
     CDS             complement(1515..1769)
                     /locus_tag="ctg1_2"
                     /transl_table=11
                     /translation="MIRKLNKKDQEILKTLGSIWLNSNIATHNFINEEYWVNNYDNVIE
                     SFKTAEIIVYEKNTEIIGFCGLIDNYIAGMFIKKSSRNQ"
     CDS             complement(1759..1989)
                     /locus_tag="ctg1_3"
                     /transl_table=11
                     /translation="MNYFRYKQFNKDVIIVAVGYYLRYAFIKRLIKQFGKPQKIITDQA
                     PSTKVAMAKVIKTRRNSFSTRFKIKVIKNDT"
     CDS             2333..2461
                     /locus_tag="ctg1_4"
                     /transl_table=11
                     /translation="MTIEFYRKELQERSKLLKNQQILTLESNKKIQKLEYKLEEEK"
     CDS             2810..3421
                     /locus_tag="ctg1_5"
                     /transl_table=11
                     /translation="MNGEEMVSNASVVFWKKKLLIITAAHSVFDWHYKKFAESISFFDY
                     EGNEVNINRIVLSNNWVSEGILDFDTAILIPDKTNDCNYNKIYPKFFYDKEQKITVLYL
                     KDKLFKKKLMCHEANTFEDYIYESSMIGVNLKAKEGYSGSPWYYKDEKGTYQITNTSLS
                     FKKYKKLTFAPYWGMHMKDMFLFSENVNNVNEKYINHILY"
     CDS             3433..3576
                     /locus_tag="ctg1_6"
                     /transl_table=11
                     /translation="MNKNSVLKLQGIRTKKSTNSQASNASVMCKKQSSVSVVFCVFPQG
                     NK"
     CDS             3860..5554
                     /locus_tag="ctg1_7"
                     /transl_table=11
                     /translation="MYKDYNMTQLTLPMETSVLIPTNDISRHVNDIVETIPETEFDEFR
                     HHRGATSYHPKMMLKVVLYAYTQSVFSGRKIEKLLNDSIRMMWLSQNQKPSYKTINRFR
                     VNPKVDALLESLFIQFHSQCLKQNLIDDQAIFIDGTKVEANANRYTFVWKKSIQNHESR
                     MNENSKALYHELVINKIIPEIKKDHDNDLTKEEIDLIGSHLDKEIEDLNQHIDNEKCTK
                     IRKQIRLKRTKIKKYKKQINDYSQRKHKYEVQKSILKDRNSYSKTDHDATFMRMKEDHM
                     KNGQLKPGYNLQIATNSQFVLFYDVYQNPTDTRTMIPFLNTIQETYGHLPEYIVADAGY
                     GSEANYMAIIDNFNRTPLITYGMFIKDKTKKYKSDIFNTQNWDYDEINDEFICPNNKRL
                     GFKRYAYRHDKYGFKRDFKLYECDDCSECPLKQQCMNFNSKTNKKIMKNYNWEYFKAQI
                     NKKLSEPKTKTIYSQRKIDVEPVFGFMKAILGFTRMSVRGIDKAKRELGFVLMALNIRK
                     VTAQRAENNQKNNKKDNFYIISIEIVFFYLSWDFMSHTQFGVVKCGL"
     CDS             5544..8102
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 69.9;
                     E-value: 4.2e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_8"
                     /sec_met_domain="micKC (E-value: 1.3e-135, bitscore: 444.6,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 2.2e-16, bitscore: 51.2,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.9e-46, bitscore:
                     149.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYRYVKYINNSRYYTKPSYENEGIINLKQVPHNFEIVQGEHWTN
                     VFNNTQHLPKQGWKIHICTQLKEARKTLDIVSNLMFKENVSFKYVKSMHELMLKDSKYG
                     DRSSSGKFITIYPSSNEQFIDLLKKLEHELSNLPKGPYILNDKRWYKSNVYFRYGGFMP
                     RTFRYNGEILDAIEDPNGNLIEDQRKPYYVLPDFIEEPEEIKKMNLEVDHEYKRTPLDN
                     YNIKEALHFSNGGGVYLAEHNKWGNVVLKEGRPHTSTGFDNIDAFERVENEGKVLKKLM
                     KANYPAKIYDSFSAWEHKFIVEEYIEGDSLSIWMVNKYPFSSESNNENYVKSSINILNQ
                     LIKAIKELHNLNIGFGDLQPANIIVSKEEKIRLIDFETAGSINDSLSSVMTPGFIGSPK
                     MNKGQGDWFAVLRIAKQMFIPIGSVQDISHNLDSVHNSWIKSTFGQEALHIIKKIENIC
                     KYQNSRPMKEFITSQNKTVRNFNLLSVKEKLINCIKNDLRDEELLMHGDIRQYEMNSGK
                     WNVLTGGFGVIMAVKRSGEWDEKFDKWIKSIDYSNLGYLENGLYTGKIGIANVLIESGY
                     IKEAATIIKTINIEDSNQDISLASGLSGLGLGFLSIYYELKENIYLDESKKIGEMLENN
                     FQDNTPVYTFDYDIVDKGFLTGWSGASLFMSCLYRATNNEKWLHLSRKMLNKELEKTLF
                     DDTGLFQVDDDFRILPYLSSGGAGLAIPMIAYESIVNESIWRKELEGISKIAKSKTFFN
                     GGLFQGTTGIVAISNLLDNYLNKEDLTKSSLFTLNLHLIETENCIYLPGDSCFRVSSDL
                     MSGTAGLLTVVDDIINNSYFSWLPLLNIDKLINLDKITRR"
     CDS             8112..8237
                     /locus_tag="ctg1_9"
                     /transl_table=11
                     /translation="MKNVLDLQQMRSKAGKKKPTRKQSSTSWGCAPSSNTSWFFC"
     CDS             8276..8395
                     /locus_tag="ctg1_10"
                     /transl_table=11
                     /translation="MNKVLSLQQETVSKEVQLKAKSSKSQNCKNSSHSSWFIC"
     CDS             8453..10180
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 261.8; E-value:
                     2.2e-79)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_11"
                     /transl_table=11
                     /translation="MELFNLNVYNILKIAIDNKSKKIYLAVIIIISLIFTLASLYFPLI
                     IKNIITELEKNKVSVFIICYLILFLILRSVMESINEYLIAKLGNIVIKDLQQNIYDRIV
                     NYPISFFDEYNSGDLSSRLVNDTEVIKDLITFHIPKVINGLVMIVGAVCLIVLLDWKLT
                     VLILLISPVIFGIIFPLMKKLENTGEIQQNEISNFISKTQETFKNIRMVKASTAEQSES
                     KSISRYINNLFKVNLYESKVMSLVSPLVNLLLIFGLLIIAGYGAYRIQNDTLTLSTLIA
                     FIIYSFQLMSPISSISSFIGEYHKSNGAFKSLTVILSKDIENAKNTYKYNFKLEDKLIF
                     DNVSLEFKEKKILDNISFKLNKGESLTIIGPSGSGKTTLLNVIEKFYYINSGSITIDGI
                     DINDINTQNLRYNIGLVSQDIPIISGTIKDNLLYGLNNVSITNFEIKDILKSTMLKDLV
                     INQIDGINSYVGESGNRLSGGEKQRINIGRVLLKNPNIILLDEATSNLDNESKSEIINS
                     ISEITQDKTVLKITHNMHELKEDEQILFIENGKIIFKGKHGELLKNNERYKKFIKNEA"
     CDS             10260..10583
                     /locus_tag="ctg1_12"
                     /transl_table=11
                     /translation="MNIQFKKGALELLVLLIVKQEDQYGYSLSQIITNRIAISEGTIYP
                     LLRKLVREEYLESYYTPSKEGPSRKYYSITSKGNVRLNLLLREWNNFTEAINMFVKESG
                     LHE"
     CDS             10576..11145
                     /locus_tag="ctg1_13"
                     /transl_table=11
                     /translation="MNKEEYLRIIKKGIKKVDAKEKEDILNEYESHFISGYKDNKDDTE
                     IIKELGNPIKVAKEINAVNSIYKIEKEKSVKSIFSAAFSIMGLSIFNLFLIIISFFIFL
                     LLLPFVLAYFIAVPIMIFSPIILLVMGCINGFDTINTGDIFEVIKGVVLGIILAFIGYF
                     IAKYFLKLLVLYLNWNIDVYKKEKLK"
     CDS             11142..11753
                     /locus_tag="ctg1_14"
                     /transl_table=11
                     /translation="MKYIYIYLLLIFSIILVSCSNSIDNNNSKENSEDKIVEKPLPKKI
                     FDKNKDGQYITENEIRKSIKLYLDKNEELSEASEYYEDKIDSEESLSQNEIKKLKKLNN
                     LNQKNDENFKSYIKSNKLPKSYRKDTERISKYISHSNKYSQNLEKKIDKIIDKGINQKK
                     VSIKDIGKIENDSTIVNGREQSKIEKFLNEKNIKTKAFKK"
     CDS             complement(12317..12796)
                     /locus_tag="ctg1_15"
                     /transl_table=11
                     /translation="MIIGYARVSSIDQNLERQLENLKTFGAEKIFTEKQYGKSIENRPV
                     LQEALNFVRMGDRFIVESIDRLGRNYDEVINTVNYLKDKEVQLMITSLPMMNEVIGNPL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKEKGVYKGHLLLYSPNAKNP"
     CDS             complement(13136..13378)
                     /locus_tag="ctg1_16"
                     /transl_table=11
                     /translation="MFNNKNGDTLIKDGVPKDYKVADKSGQAITYASRNDVAFVYPKGQ
                     SEPIVLVIFTNKDNKSDKPNDKLISETAKSVMKEF"
     CDS             complement(13551..13763)
                     /locus_tag="ctg1_17"
                     /transl_table=11
                     /translation="MLEQVPYNKLNKKIHINKDDIVAYSPILEKYVGKDITLKELIEAS
                     MTYSDNTANNKIIKESVESKKLNNI"
     CDS             complement(14190..14366)
                     /locus_tag="ctg1_18"
                     /transl_table=11
                     /translation="MDICCELLNRFGGIYVMFKSCDLLSTVALIIHIIKFKKENLIGMK
                     GINPARRVRYQTL"
     CDS             14502..14702
                     /locus_tag="ctg1_19"
                     /transl_table=11
                     /translation="MKKNKIDTILFNHQYKKNIVIRKAETIQSPITFWYGKYIILIPSS
                     YFKSVIDKRLKYIILHEYAHA"
     CDS             14695..14835
                     /locus_tag="ctg1_20"
                     /transl_table=11
                     /translation="MPKNRDTLHLIIFNIFSIIMSYNPLVHIVKRKIIHDNEVEADRIC
                     P"
     CDS             14878..15054
                     /locus_tag="ctg1_21"
                     /transl_table=11
                     /translation="MDSVLNVPFFNKNILSHSFNGKESLLKRRLINIKEATSEKTVQIN
                     SNFYLYFLLFCSW"
     CDS             15321..15797
                     /locus_tag="ctg1_22"
                     /transl_table=11
                     /translation="MSWDHKHYPFDAWNKEQNLNTAMQNSVNWYFERISDQIPKNYTAT
                     QLKQLNYGNKNLGSYKSYWMEDSLKISNLEQVIVFKNMMEQNNHFSKKAKNQLSSSLLI
                     KKNEKYELYGKTGTGIVNGKYNNGWFVGYVITNHDKYYLLHIYQMESHLGKMLN"
     CDS             15834..16118
                     /locus_tag="ctg1_23"
                     /transl_table=11
                     /translation="MANKQVEISMAEWDVMNIIWGKKSVSANEIVVEIQKYKEVSDKTI
                     RTLITRLYKKEIIKRYKSENIYFYSSNIKEDDIKMKTAKTFLNKLYGGT"
     CDS             16115..16213
                     /locus_tag="ctg1_24"
                     /transl_table=11
                     /translation="MKSLVLNFAKNEELNNKEIEELRDILNDISKK"
     CDS             16477..17070
                     /locus_tag="ctg1_25"
                     /transl_table=11
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTHGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNKQDLNLLKTLYDNGTPI
                     KTIAEQWKVSRTTIYRYLNKLEDKEDEKQGEVSN"
     CDS             17042..17866
                     /locus_tag="ctg1_26"
                     /transl_table=11
                     /translation="MKNKEKYLTNFSEAKRKEATQKYNIIKPFILGNQSLSSISKNKDI
                     ALSTLYRWNKLYKEEGLTGLIHNTRVDKGDHKLEQNIIDEIKRLSLKNKRNSIATIHRK
                     IVNYCIEKNFDKPSYKQVYSIIKAMPKSVIDFSHQGEKYYQNKYDLIQIRESSRPNEIW
                     QADHTLLDIYILDQTGNINRPWLTIIMDDYSRAIAGYFISFEAPNAQNTALTLHQAIWN
                     KNNTNWPVCGIPEKFYTDHGSDFTSHHMEQVAIDLKINLMFSKVGVPRGRGK"
ORIGIN
        1 ttcactcaac atttttacac ttttcacata atcaaccctt tataaatagt ttatcaaccc
       61 tttataaaac attataaggc tataagtccc caaatataaa gttattcgcc ataaataaaa
      121 tacgtcttat caaagtttta tctagggttg atagtttcat caaaggttcg taaaaggttg
      181 ataaaccttt gataaccatg cattttctcc tttaataacc ctatttaaag tgctataata
      241 tacttaacat atcaaaagcc ccccaactac tggtaatagt cgggggggct ggtaataaaa
      301 cgttatagca cgtttgttta atatcaaatt tatacttgta ttatataatg aataacatct
      361 tagtgcaagc gcctaaatct ttaaataaat ataaagctat ataaaaacgt tttattacct
      421 cttaccaaac taaatttcgg aagaggtttt tattatgtca aattttaaaa gaattacaat
      481 acaagaattt gaacaagaaa gattttataa actatataaa tttttatttg aagatgatta
      541 ttttagaaag cttagtgact ctgcaaaaat tgcttactgt atgtttaggg atcgattcga
      601 attatctaaa atgaataatt ggattgatga caatggtaat gtatatttaa tatttactac
      661 taaagattta tgtgaacttt taaattgcgg aactcaaaaa gtaactaaaa tcaaaaaaga
      721 attagaaaat tttaatcttt tagaacaaga aagaatgggt ttaaacaaac caaataaaat
      781 atatatccta gagcctaaaa aaacttctaa aactgatgat agtaaggaat ttcgaaaatc
      841 aaaattccag aataatgaaa atcaaaattc cagagttttg aaagtcaaaa aacaagaatt
      901 tcgaaaatca aaatctaatg atactgaatt taataatact gattatatag agactgatta
      961 taatgatttg aatgatttga atgatacaaa taataatatt tctacaacta ataatcattc
     1021 gaatcattca aattatcaaa aaaataaatt taataatgat gctttaaaat ttcaagtact
     1081 tgaagaatta ccaaatcaaa tcaaagatta tttaagtaat tttgaaatca gagagattcg
     1141 tattattaag agtgttttac ttaaagggaa aaagtctttt aataatacac aagatacata
     1201 ttaccgttta gaagatgttg aatttgagtt agtaaatgtc ttaaaacgtt ttaaagcaat
     1261 gttgctacaa aaaaatgaaa cagttgaagc catgcaaggt tatttaatgc aatcaattaa
     1321 agctgaacta gaagaaatac atacgttgaa tatgcgccgt caaaatatgc cgaaatacaa
     1381 tatatttaat gaataattca aataatctga taacaacaaa gagaattcat cggttaaatc
     1441 atcaaaaaaa tagaagtttt gtaatatgtt aagtgtgttt atctttgggg ttttacctat
     1501 atttgttttg attgctattg gtttcttgaa ctctttttaa taaacattcc tgcgatatag
     1561 ttatcgatta aaccacaaaa tcctataatt tctgtgtttt tttcgtatac gataatttct
     1621 gccgttttga aagattctat aacattatcg taattattaa cccaatattc ttcgttaata
     1681 aaattatggg ttgctatatt agaatttagc cagatacttc ctaaagtttt taaaatttct
     1741 tggtcttttt tatttaattt acgtatcatt ttttatcacc ttgattttga aacgagttga
     1801 aaacgagttt cttcttgtct tgatgacttt agccattgcg accttcgttg aaggtgcctg
     1861 atctgtaatt atcttttgag gtttaccaaa ttgtttaatg agacgtttga taaatgcata
     1921 tcttagatag tagccaacgg ctacaatgat aacatccttg ttaaattgtt tatatctgaa
     1981 atagttcata gagaaaactc ctttttgtta aatttatact ataaattcaa ctttgtaaca
     2041 gaaccttagt aagcaaacaa tttttaataa cattaaacga ctaaatataa aaacgataaa
     2101 gcaagaaaac tcttcatata tcaaagaaga tgccgacata gaaaaagtta ttcaaagagt
     2161 aaatgcaaat aaaaagaaat atggctttga aagtacaacg agcactgaaa aaagcaatga
     2221 ttcagataat actaattcta aatttgaaaa ttatattcaa ttaatagaaa cacttaaaaa
     2281 taaaatatct attttaaata ataaaattca aaaacaggaa agttgtcaca aaatgacaat
     2341 agaattttat aggaaagaat tacaggaaag gtcgaagcta cttaaaaatc agcaaatatt
     2401 gactttagaa agtaataaaa aaattcaaaa attggagtac aaactagaag aagaaaagta
     2461 acttaactat acatctaagt ttgatactag taataaacag accaataatg tacaaaaagc
     2521 tacttttaat gaaaaagatg agaaaataaa aaaacaaata gcaaaagaaa atgaattctt
     2581 taaggatgat aataaatatg aaaaaacaag taataattct gtgaatagtt tagtaaaaga
     2641 acgtaaaaaa gtttttaaaa agtatttttc ggtcttttag tgtaattttt cattttggat
     2701 ggatattgaa aaaagcaatg tttaatgata attttaagat gttaatatat aagtaaggga
     2761 gaagtgttga ataatacata ttaaaaatat aggtattata aaagttcaaa tgaatggtga
     2821 agagatggtg tcaaacgctt ctgttgtttt ttggaaaaaa aaacttctaa ttattacagc
     2881 agctcatagt gtttttgatt ggcattataa aaaattcgca gaatctatat ctttttttga
     2941 ctatgaagga aatgaggtta atatcaacag aattgttcta agtaataatt gggttagtga
     3001 aggtattttg gattttgata ctgctatatt aattccagat aaaacaaatg actgcaatta
     3061 caataagata tatccaaaat tcttttatga taaagaacaa aaaataactg ttttatattt
     3121 gaaggacaaa ttatttaaaa aaaaattaat gtgtcatgag gctaatactt tcgaagacta
     3181 tatatacgaa tcgagtatga ttggtgtaaa tctaaaagct aaagaaggtt actctggatc
     3241 tccttggtac tataaagatg aaaaaggaac atatcaaata acaaatacaa gcctctcttt
     3301 taaaaaatat aaaaaattaa catttgctcc atactggggt atgcatatga aagatatgtt
     3361 tctattttct gaaaatgtaa acaatgttaa tgaaaaatat attaatcata tattatatta
     3421 ggaggtgaaa taatgaataa aaatagtgtc ctaaaattac aaggtatacg cacaaaaaaa
     3481 tctacaaata gccaagcatc aaatgccagt gttatgtgta aaaaacagag tagtgtaagt
     3541 gttgttttct gtgtatttcc acaaggaaat aaataacatt taattaaaag ggcctgggac
     3601 ataattccta tcaaaatagc cagtaaatga gttttcataa attcatttac tggcttcttt
     3661 atttacaata cttcgtattg ttggctcgct ttcttagggg acagcttcag cctgtagtct
     3721 tcagcttgtc ctgttccctc aagagtctcg ccaaaatact ttgtattcat atgtaatttt
     3781 acattaaaat actttaaaaa aataaggccc tttcgtataa tttaataaac atcactaaac
     3841 taaattaacg aggtgcctta tgtataaaga ttataacatg actcaactta ctctaccaat
     3901 ggaaacttca gttcttatcc ccacaaatga tatttcacga catgtaaatg atattgtaga
     3961 aacaattccc gagactgaat tcgatgaatt cagacatcat cgaggtgcaa catcatacca
     4021 tccaaaaatg atgttaaaag tagttttata tgcctacacc caatctgtgt tttcaggacg
     4081 taagatagaa aaattactca atgatagtat ccgaatgatg tggctatcac aaaatcaaaa
     4141 gccttcttat aaaacgatta atcgatttag agtaaatccc aaagtagatg ctttattaga
     4201 atcattattt attcaatttc atagtcagtg tttgaaacaa aatcttattg atgatcaggc
     4261 catttttatt gatggtacga aagttgaggc aaatgccaat cgatatacat ttgtatggaa
     4321 aaagagtatt caaaaccatg agtcaagaat gaatgaaaac tctaaagcac tctatcatga
     4381 attggtgata aataaaatca tacctgagat taaaaaagat catgataatg acttaacaaa
     4441 agaagaaata gatttgattg gtagtcattt agataaagaa atcgaagatt taaaccaaca
     4501 tatcgataat gaaaaatgta ctaaaataag aaaacaaata cggctcaaaa gaactaaaat
     4561 taaaaaatac aaaaagcaaa ttaatgatta ctctcagcga aagcataaat acgaagtcca
     4621 aaaatctatt ttaaaggata gaaatagtta ttctaaaaca gatcacgatg ccacatttat
     4681 gagaatgaaa gaagatcata tgaaaaatgg acaacttaaa ccggggtata atttacaaat
     4741 agcgacaaat tctcaatttg ttttatttta tgatgtgtat caaaatccga ctgatacaag
     4801 aacaatgata ccttttttaa atacaataca agagacctac ggtcatttac ctgaatatat
     4861 tgtagctgac gcaggttatg gtagcgaagc caattatatg gcaattatag ataattttaa
     4921 tcgaacgcca ctcataactt atggaatgtt tataaaagat aaaactaaaa aatataaaag
     4981 tgacatcttt aatactcaaa attgggatta tgacgaaatt aacgatgaat tcatttgtcc
     5041 gaataataaa agactaggat ttaaaagata tgcctatcgt catgataaat atggttttaa
     5101 acgagacttt aaattatatg aatgtgatga ttgttcagaa tgccctctga aacaacaatg
     5161 tatgaacttc aattcaaaaa caaataaaaa aataatgaaa aattataatt gggaatattt
     5221 taaagcccaa attaataaaa agctttcaga accaaaaaca aaaaccatct acagtcaaag
     5281 aaaaattgat gtggagcctg tttttggatt tatgaaggct attttgggtt tcactagaat
     5341 gtccgttcga gggatagata aagccaaaag agaattagga tttgtgctaa tggcacttaa
     5401 tataagaaaa gtaacagctc aacgagctga aaataatcaa aaaaataata aaaaagacaa
     5461 tttctatatt atttcaatag aaattgtctt tttttactta tcctgggact ttatgtccca
     5521 cactcaattt ggagttgtta agtgtggatt atagatatgt aaaatatata aataatagtc
     5581 ggtattatac aaaaccttct tatgaaaatg aaggcattat aaatttgaaa caagttcctc
     5641 ataattttga aatagtccaa ggagaacatt ggacaaatgt tttcaataat acacaacatc
     5701 tacctaaaca aggatggaaa atacatatat gtacacaact gaaagaggct agaaaaactt
     5761 tagatatagt ttctaatctt atgttcaaag aaaatgtatc ttttaaatat gtaaaaagta
     5821 tgcacgaatt gatgttaaaa gattcaaaat atggagatcg gagttcttcg gggaagttta
     5881 ttactattta tccatcttca aatgaacaat tcatagattt attaaaaaaa ttggaacatg
     5941 agctatctaa tcttcctaaa gggccgtaca ttttaaatga taaaagatgg tataaaagta
     6001 atgtctattt tagatatggt ggttttatgc ctaggacttt tagatataat ggggagatat
     6061 tagatgctat agaagatcca aatggaaatc ttatagaaga tcaaagaaag ccctattatg
     6121 tattacctga ttttattgag gaacccgaag aaataaaaaa aatgaatttg gaagttgatc
     6181 atgaatataa aagaactcct ttagataact acaacataaa agaggctctg cattttagta
     6241 atggtggtgg ggtttattta gcggaacata ataaatgggg taatgttgtg ttaaaagaag
     6301 gtcgtccaca cacatcgaca ggcttcgata atattgatgc ttttgaaaga gttgaaaacg
     6361 aagggaaagt attgaagaag cttatgaaag caaattatcc agccaaaata tatgattctt
     6421 tttcagcttg ggagcataaa tttattgtag aagaatatat cgaaggagat tctttgtcga
     6481 tttggatggt taacaaatat ccattttcat cagaatctaa taatgaaaat tatgtaaaat
     6541 cttcaattaa tatcttaaat caattaatta aagctataaa agaactccac aatttaaata
     6601 taggttttgg agatcttcaa ccagctaata ttatagtaag taaggaagaa aaaataagat
     6661 taatagattt tgaaactgca ggttctatta atgattcatt atccagtgta atgactcctg
     6721 gctttatagg tagtcccaaa atgaacaaag gccaaggaga ctggtttgct gtactaagaa
     6781 ttgctaagca aatgtttatt cctataggaa gcgtccaaga tatttctcat aatttggaca
     6841 gtgttcataa tagttggatt aaatcaactt ttggacaaga agctttacat attataaaaa
     6901 aaatagaaaa tatatgcaaa tatcaaaatt ctagaccaat gaaagaattt atcacttctc
     6961 aaaataaaac agtcagaaat tttaatttac tatctgttaa agaaaaactt ataaattgta
     7021 taaagaatga tctaagagat gaagaattgc ttatgcatgg agatataaga cagtatgaaa
     7081 tgaattctgg taagtggaat gttttgactg gtggatttgg tgtgattatg gcggttaaaa
     7141 gatctggaga atgggatgaa aaatttgata aatggattaa gagtatagat tactccaatt
     7201 tggggtattt agaaaatggg ttatatactg ggaaaatagg tatagcaaat gtactaatag
     7261 aatctggata tataaaagaa gcagcaacaa taattaaaac tattaatatt gaagatagca
     7321 accaagatat ttcattggca tcaggtttaa gcggtttagg tttaggtttt ttaagtatat
     7381 attatgagct taaagaaaat atttatttag atgaaagtaa aaaaataggt gaaatgcttg
     7441 agaataactt ccaagataat acacctgtgt atacttttga ttatgatata gttgataaag
     7501 gattcctaac tggttggtca ggtgcttctt tatttatgtc atgtttatat agagcaacta
     7561 ataacgaaaa atggttacat ctttctcgta aaatgttgaa caaagagtta gaaaagacat
     7621 tatttgatga tactggatta tttcaagtag atgacgattt tcgtatactg ccttatctat
     7681 ctagtggtgg cgctggttta gcaataccta tgattgcata tgaaagtata gtaaatgaat
     7741 cgatatggag aaaagagtta gaaggtatat caaaaatagc taaaagtaaa acatttttca
     7801 atggaggatt atttcaaggt actaccggta tagtagctat aagtaattta ttagataact
     7861 atttaaataa agaagatttg actaagtctt ctttatttac attaaattta catttaattg
     7921 aaacagaaaa ttgtatttat ttaccaggag attcatgttt tagggtttca tctgacctta
     7981 tgtcaggaac tgcaggattg ttaacagttg ttgacgatat tattaataat agttattttt
     8041 catggttacc tttacttaat atagacaagc ttataaattt agataaaatt acaaggaggt
     8101 gaagttggta tatgaaaaat gtattggatt tacagcaaat gagaagcaaa gctggtaaaa
     8161 agaagccaac aagaaaacaa tctagtacta gttggggatg tgctccttct agtaacacta
     8221 gttggttttt ctgttaattt tgtgtgatat tcctgattaa ggaggtgagt taactatgaa
     8281 caaagtatta tctttgcaac aagaaacagt ttcaaaagaa gtacaattaa aagctaaatc
     8341 ttcaaaaagt caaaactgta agaatagtag tcattctagc tggtttattt gctagaaatt
     8401 aaaagaggca ataagatcgt attaaaaata ctatcttatt gtctcaattt ttatggagtt
     8461 gtttaatttg aacgtataca atattttaaa aatagctatt gataataaaa gcaagaaaat
     8521 ttatttggca gttataatta tcatttcttt aattttcaca ttagcttctt tatatttccc
     8581 tttaataata aaaaatatta taacagaact tgaaaaaaat aaagtgagtg tttttattat
     8641 ttgctattta attttgtttt taatattaag gtcagttatg gaatctataa atgagtattt
     8701 aatagctaaa cttggaaata tagttataaa agacttacaa caaaatattt atgatcgaat
     8761 agtaaactat ccaatatcat ttttcgatga atataatagt ggagacttat caagtagact
     8821 agtaaacgat acagaagtaa ttaaagattt aataacattt catattccta aagttattaa
     8881 tggattagtt atgattgttg gggctgtttg tttaatagtg ttattagact ggaaattgac
     8941 agtactaatt ttacttatat ctcctgtaat atttggaatt atatttccat taatgaaaaa
     9001 attagaaaat acaggagaga tacaacaaaa tgaaatctcc aattttatat caaaaactca
     9061 agaaacattt aaaaatatta ggatggtaaa agcttctact gcagaacaat ctgagagtaa
     9121 aagcatttct agatacataa ataatttatt taaagtaaat ttatatgaaa gtaaggttat
     9181 gtctttagta tctcctttag tgaacctttt acttattttt ggcttactaa ttatagctgg
     9241 atatggcgca tatcgaattc aaaatgatac tttaacttta agtactctta ttgcatttat
     9301 aatttactca ttccagttaa tgagtcctat aagttcaata agtagtttta taggagaata
     9361 tcataaatct aatggagctt ttaaaagctt aactgttatc cttagtaagg atattgaaaa
     9421 tgctaaaaat acatataaat ataattttaa gttagaggat aaattaatat ttgataatgt
     9481 aagtttagaa tttaaagaaa aaaaaatcct tgataatatc tcttttaaat taaataaagg
     9541 ggagtctctt acaattatag gtccttcagg atctggaaaa acaacattat taaatgtaat
     9601 agaaaaattt tattatataa acagtggaag tataactata gatggtatag acattaatga
     9661 tatcaacact caaaatttaa gatacaatat aggattagtt agccaagata tacctattat
     9721 aagtggtaca ataaaagata atttactata tggattgaat aatgtaagta ttaccaattt
     9781 tgaaattaaa gatattttaa aatctactat gctaaaggat cttgttatta atcaaattga
     9841 tggtattaat agttatgttg gagaaagtgg taatcgtctt tcaggcggcg aaaaacaaag
     9901 aattaatata gggagagtac ttttaaaaaa tcctaatatt attttattag atgaagcaac
     9961 ttcaaatcta gataatgaat ccaaatctga aattattaac tctatatctg aaataacaca
    10021 agataaaact gttttaaaaa taacacacaa tatgcatgag ttaaaagaag acgaacaaat
    10081 attatttata gaaaatggga aaattatttt taaaggaaaa catggtgagt tgctgaaaaa
    10141 caatgaaaga tataaaaaat tcattaaaaa tgaggcttag tactttacct atagtttaaa
    10201 ataaggtatt atactatata cagtagttag tataacttat atgagagggg cattatttaa
    10261 tgaatattca atttaaaaaa ggcgccttgg aattattagt tttattaatt gtaaaacagg
    10321 aagatcaata tgggtactca ttaagtcaaa ttataactaa taggatagct atatctgagg
    10381 gtactatata tcctttgcta cgtaagcttg taagagaaga atatttggaa agttactata
    10441 ccccctctaa agaggggcct tcgagaaaat attatagtat aactagtaaa ggtaatgtac
    10501 gtttaaattt actactcaga gaatggaaca actttactga agcaataaat atgtttgtga
    10561 aagagagtgg tcttcatgaa taaagaagag tatttaagaa taattaaaaa aggaattaag
    10621 aaagtagatg ctaaggaaaa agaagatatt ttaaatgaat atgaatcgca ttttattagt
    10681 ggatataaag ataataagga tgatacggaa attattaaag agttaggtaa tcctataaag
    10741 gtagctaaag agataaatgc tgtaaattca atatataaaa tagaaaagga aaaaagtgtt
    10801 aaaagcatat tttctgcagc attttctatt atgggactta gtatcttcaa cttattttta
    10861 ataataatta gtttttttat ttttttatta ctcttacctt ttgtactagc ttactttatt
    10921 gcagttccaa taatgatttt ttcaccaata atattattag taatgggttg tataaatggc
    10981 tttgacacta ttaatacagg agacattttc gaagttatta aaggggtagt tttaggaatt
    11041 atattagcct ttattggtta ttttattgct aaatatttct tgaaactttt ggttctttat
    11101 ttgaattgga atatagatgt atataaaaag gagaaattaa agtgaaatat atatatatat
    11161 atttattatt gattttttca attattttag tgagttgctc taattctata gataataata
    11221 attctaagga aaatagcgaa gataaaatag tagaaaaacc attacctaaa aaaatatttg
    11281 ataagaataa agatggacaa tatataacag aaaatgaaat tagaaaatca ataaaactgt
    11341 atttagataa aaatgaagaa ttatctgaag ctagtgaata ctatgaagat aaaatagatt
    11401 ctgaagaatc gctgagtcaa aatgaaatta aaaaacttaa gaagttaaat aatttaaatc
    11461 aaaaaaatga tgaaaatttt aaaagctata taaaaagcaa caaattacct aaaagttaca
    11521 gaaaagacac agaaagaata agtaaataca tttctcattc taataaatat tcccaaaatt
    11581 tggaaaagaa aattgataaa ataatagaca aaggtataaa tcaaaaaaaa gtatcaatta
    11641 aagatattgg aaaaatcgaa aatgatagta caatagtgaa tggaagagag caatctaaaa
    11701 tagaaaaatt cttaaatgaa aaaaatatta aaactaaagc ctttaaaaag taattactta
    11761 ttcatcaact ttttattttt acagttagaa tcacaataat ttaaatcaca aaccacccgt
    11821 gtgaacgggt ggtttgttct acgtttataa acctctttta ttggccagcc caaaaggaca
    11881 ctgacaggtc agtcaactgc actactttcc catcacaccc cctaaaaggg tactattttt
    11941 ttcgtctttt tttaatttct tctcctgtaa atggacctat gtattcttct attgaaattt
    12001 gatctgcaac gatattctct tgtaattgat tacgaatgta attttcaatt acctttttat
    12061 tgctacctac tgtatctaca taaaatcttt tacaccaaaa ctatctattt ccatatctat
    12121 attttaaatt gacttgtcta tcaaaaatta ttaaaatact ttcacctttt aaatatccaa
    12181 caaataatga tgctcttcat ttaggtggaa tactcactaa catatgaata tgatttttac
    12241 atgcttctcc ttatattatt tctatgcctt ttccttcttc taacatttct gcaactcgat
    12301 aatagataat acgtttttat ggatttttag cgttaggaga atacaataaa aggtgccctt
    12361 tatatacacc tttttctttc gcaacttgaa taccttgtgc ttgtctacgt ttactttcat
    12421 ttcgttcttg ttctgaaacc attgctagta tttgaatgat taggtctttc ataaatttat
    12481 ctaataatgg attaccgatc acttcattca tcataggtaa gctagtaatc atcaattgaa
    12541 cttctttatc ttttaaataa ttaactgtgt taatcacctc atcataatta cgacctaaac
    12601 gatcaatgga ttctactata aatcgatccc ccattctcac aaagttaagt gcttcttgaa
    12661 gtaccggtct attttcaata gatttcccat actgtttttc tgtaaatatt ttttcagcac
    12721 caaacgtctt taaattttca agttgccttt ctaaattttg atcgattgat gacactctcg
    12781 cataaccaat aatcattgat ttcacctcat aattaatata caccctaatc atacgtttaa
    12841 gttacttgtc actttgcttg atatatgaga attatttaac cttataaatg agaaaaaagc
    12901 aacgcacttt aaataagata cgttgctttt tcgattgatg aacacctata attaaactat
    12961 tcatctatta tttatgattt tttgtatata caatatttct agtttgttaa agagaattaa
    13021 gaaaataaat ctcgaaaata atagagggaa aatcagtttt tgatataaaa attatacatg
    13081 tcaacaataa tacaaactat aagatgatat cagtatttat tatgcattta gaatattaaa
    13141 attccttcat tacactcttg gcggtttcac ttatcaactt atcatttggc ttatcacttt
    13201 tattgtcttt attcgtaaaa atgactaaaa caataggttc agattggccc ttaggataaa
    13261 caaaagcaac atcatttcta gaagcatatg ttattgcttg accactttta tcagcaacct
    13321 tatagtcttt tggaacacca tctttaatta aagtgtctcc gtttttatta ttaaacatta
    13381 aatcaagtaa gaaattttta ttttttttgc ttaattttcc atttgcgata agtttattta
    13441 aagtcttgcc gaaagcagca ggcgttgaag tatctttttt gctctttggt gaatagtaat
    13501 ttaattctat ctcatatcta actggatttg ttacttatct cctagttctt ttagatgttg
    13561 tttaactttt ttgattccac cgattctttt ataattttat tgtttgctgt attatcacta
    13621 tatgtcattg aagcctcaat aagttctttt aaagtgatat cttttcctac atatttttct
    13681 aaaataggag aataagcaac tatatcatct ttgttaatat gtattttttt atttaactta
    13741 ttataaggta cttgttctaa caaaatagca ctatttatcg cttttgaagt cgaagcatag
    13801 gcaaatctct tatctgaatt aaattttact tccttaccac ttttagtatc taaagcataa
    13861 acaccaatat gagcattata ttttttttct aaatcattta actcttgggt atgtgaactg
    13921 tttgaattac atgcaactta aaactaaagc aattacaatt aaaaatatta actttttcaa
    13981 ataaaccctc cgatattaca gttgtaattt ttataaatca ataatattac aattgtaata
    14041 tcggtgtcaa tagtttatta taaatatttg aaagaaggtg ttgaaatggc taagttatta
    14101 ataatgagca tagtaagctt ttgttttata tttctattgt tattattttt tagtacatat
    14161 taaaaacgct attttaatta tatgttaaat tataaagttt ggtatctaac tcttcttgca
    14221 ggattaattc ctttcattcc tattaaattc tcttttttaa atttaataat gtgaataatc
    14281 agcgccacag ttgaaagtaa gtcacacgac ttgaacataa cataaatacc accaaaccta
    14341 ttcaagagtt cacaacagat atccataagt ttaattggga ttcaattgat aatatctgca
    14401 cagttatttg gatagttttt agttatattt taagtttaaa tttttgaaag ccttattata
    14461 tcttaaatat ttaaagaaac agtcacttta tctaaacgaa aatgaaaaaa aataaaatag
    14521 atacgatact tttcaaccat caatataaaa aaaatattgt gattcgaaaa gcagagacta
    14581 ttcaatctcc aataactttt tggtatggga aatatattat tttgattcct agttcatatt
    14641 ttaaaagtgt aattgacaaa agactaaaat atataatatt gcatgaatat gctcatgcct
    14701 aaaaatagag atactttaca tttaattatc tttaatatct tctctattat tatgagttac
    14761 aatccattag tacatattgt aaaaagaaag ataattcatg acaatgaagt agaagccgat
    14821 agaatttgtc cttaataata ttaacaaaat gaatttaaaa cttatgcgga atctattatg
    14881 gactccgtat taaatgttcc attttttaat aaaaatatat taagccattc atttaatggt
    14941 aaagagtcat tactcaaaag aagattaatt aatataaaag aagccacatc tgaaaaaaca
    15001 gtccaaatta attctaattt ttatttgtat tttttacttt tttgctcatg gtaattcaaa
    15061 gccagttttt gatggggcaa tccataactg attataatta taaaaagccc ttacacaaac
    15121 ggttaccaaa ttttagataa aagtaaaatt tttggttcaa atagtggatc tttcgtcatg
    15181 tacagcatga agaaagacaa atactatatt tataacgaaa aagaaagtag aaaaaggtat
    15241 tctcctaatt caacttataa aaatttattt agctatgttt ggacttgacc gacatattta
    15301 taaatgatga aaattcacgt atgtcatggg atcataagca ttaccctttt gatgcttgga
    15361 ataaggaaca aaatttaaat acagcaatgc aaaattcagt taattggtac ttcgaacgta
    15421 ttagcgatca aataccaaag aactatactg cgactcaact caagcaatta aattatggta
    15481 ataaaaattt gggaagttat aaaagctatt ggatggaaga tagtttgaaa atatctaatc
    15541 ttgaacaagt aatagttttt aaaaatatga tggaacaaaa taaccatttt agtaaaaaag
    15601 caaagaatca attatcttct tcattattga ttaagaaaaa tgaaaagtat gaactgtatg
    15661 ggaaaacagg tacaggtata gtaaacggga agtataataa tgggtggttt gtaggttacg
    15721 taattacaaa tcatgataag tattatttgc tacacattta tcagatggaa agccatctgg
    15781 gaaaaatgct gaattaatca gtgaaaaaat attaaaagaa atgggtgttt taaatggcca
    15841 ataagcaagt tgaaatatct atggctgaat gggatgttat gaatataata tggggtaaaa
    15901 aatcagtatc agctaatgaa attgtagttg aaattcaaaa atataaagaa gttagcgata
    15961 aaacgattag aacattaatc acaagactat ataaaaaaga gattataaaa cgatacaaat
    16021 cagagaatat ttatttttac tcatcaaata ttaaagaaga cgatattaaa atgaaaactg
    16081 ctaaaacttt tcttaataaa ctgtatgggg ggacatgaaa agtttagtgc tgaattttgc
    16141 gaaaaatgaa gaattaaata acaaagaaat tgaagaattg cgagacattt taaatgatat
    16201 tagtaaaaag taattagaga tatgtttcaa acataataca tatgtaaact atgcttgact
    16261 cttattaaat tagttttgtt aataacattt aaaatatatt attaaagatg agagtgtaca
    16321 gaaaataacc attttctgta cactcgtttt ttatgtctaa ataagtatgt attacataga
    16381 attatgtgtt caaaaaccca acaaaaaatc tatgttcaca aaagaccttg tgattaagtt
    16441 atggtacact gaaggtgtat ataggaggtt tgtattttga aaataggtta tgcaagagtt
    16501 tcaactggat tacaaaattt aaatttacag gaagatcgat taaatacaca tggttgtgaa
    16561 aagatattta atgaccatat gagtggttca aaaagtaaaa gacctggttt agataaagca
    16621 attgaatttg cgaggtcagg agataccatt gttgtttgga gactagatag actaggacgt
    16681 aacatggagg atttaatcac attagttaat gaacttaacg aacgaggcgt gagttttcat
    16741 agtttagaag aaaatataac gatggataaa tcaagttcta caggacaatt attatttcat
    16801 ttattcgcag catttgcaga atttgaacgt aatttaattt tagaacgttc ttcagctggc
    16861 cgaattgcgg cacgtgcaag aggaagatat ggagggaggc ctgaaaaatt aaataaacaa
    16921 gatttgaatt tacttaagac gctttatgat aatggcacac ccattaaaac aatagcagaa
    16981 caatggaaag tttcacgtac aactatttat cgttacctca ataaattgga ggacaaggaa
    17041 gatgaaaaac aaggagaagt atctaactaa tttttctgaa gccaaacgta aagaagctac
    17101 tcaaaagtac aatataataa aaccttttat cttgggaaat caatctttat caagtatttc
    17161 taaaaataag gacattgcat taagtacact ttataggtgg aataaattat ataaggaaga
    17221 agggcttact ggtctaattc ataatacaag agttgataaa ggtgatcata aattagaaca
    17281 aaacataatt gacgagatta aacgcctttc actcaagaat aaaagaaata gtattgctac
    17341 aattcatagg aaaatcgtta attattgtat agaaaaaaat tttgataaac caagctacaa
    17401 acaagtttat agtattatta aagcaatgcc taagtctgtt attgatttct ctcaccaagg
    17461 tgaaaaatac tatcaaaata agtacgattt aatacaaata agagaatcct caagacccaa
    17521 tgaaatatgg caagccgacc atactttgct agatatttat atattagatc aaacaggtaa
    17581 tattaataga ccctggctaa ccattattat ggatgactat agtcgcgcaa ttgcaggata
    17641 ctttataagt tttgaagctc ctaatgctca aaatacagca ttaacactac accaagcaat
    17701 atggaataag aataatacca attggccagt atgtggtata cccgaaaaat tctacacaga
    17761 tcacgggagt gactttacct cgcatcacat ggaacaagtc gctattgatt tgaaaattaa
    17821 cttgatgttt tcaaaagttg gtgtccctcg tggtcgcgga aaatagaacg tttttttcag
    17881 acagttaacc aaactttctt agagcaactt cctggatata taaacaataa tgatactcct
    17941 agcgatttaa tagattttca aaatttcgaa gaaaaattac gatactttta attgaagatt
    18001 ataatcaaaa agagcatagt gctatccaga gcactcctat caatcggtgg aacagtaatc
    18061 attttttccc taatatgcca agcagtttag aacaacttga tt
//
