LOCUS       NZ_CP091660.1          12104 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP091660.1 Escherichia coli strain KFu024 plasmid pKFu024_2,
            complete sequence.
ACCESSION   NZ_CP091660
VERSION     NZ_CP091660.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-06-07 15:01:22
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 34209
            Orig. end    :: 46313
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12104
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:11053]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11053
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..12104
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12104
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             790..1188
                     /locus_tag="ctg1_42"
                     /transl_table=11
                     /translation="MISILLLTACSSPPEPPQVEWEKTPEVMNTQIMNWKPTSGVIKSD
                     NINSLWSKVLPDFKPENRLYDDSVFYAVAHSEKIVVRTSSFDNYWSAKDWLRKNGATGV
                     IEYQPLKRWLNNDYVEIYLSRINIQRLL"
     CDS             1185..1487
                     /locus_tag="ctg1_43"
                     /transl_table=11
                     /translation="MKRICKGLIVIFTVSLFTAPTYAADPCKSVFCLYGKAVGSSGGSE
                     CSSAEKDFFKNVEKKKGKIRWGKTFDLRKNFLNQCSTADPAAISLIMSKFGRVRG"
     CDS             1588..2667
                     /locus_tag="ctg1_44"
                     /transl_table=11
                     /translation="MKVTKSIIVILLGSLGLFSGSSYASCTYHLTGNSETIDLSGCVAT
                     AENTANTASSTASNALTIAQKAQTTADTANTTAQSAQTTANEASSAAQNALNAANTAQT
                     TADAANTAAQSAQTTANQAIQDAAEKAEAAEENANNYTDNKITDAKNELNTNIDSAKND
                     AINSSNSYTDSKIGDTKTELNASIDKAKNDAISSSNSYTDNKISDTKTELNTSIDNAKN
                     EAISTSNNYTDKKYQQGIQYAQNAADKAEQNANNYTDNRFSQLSNQSNQRFEQLNSKIE
                     RAEKRLNAGIAGVTAISSIPYVAENSFSYGIGVGNYQNGNAIAAGIQYKTSLNTNVRLN
                     VSWDSSHNTVLGAGFAGGW"
     CDS             2701..2928
                     /locus_tag="ctg1_45"
                     /transl_table=11
                     /translation="MKPLVYAVILSLTTFSAFAKQNSANSQKTGASNIERQSYENTDAG
                     KKQAEWMKGKLVKSDCSPAMNRIGWSEGCK"
     CDS             3008..3529
                     /locus_tag="ctg1_46"
                     /transl_table=11
                     /translation="MKIILITFIFLFTVFQSANAGGIPGVFTLNLEIQGKVIRVLDGDT
                     IEVKTLPAKIVVYEVPIRVRLINIDAPEKKQPFGRWSRNQLKALLAGQSVTVSYTQTDR
                     YGRIVGRVFTTNGTEASRFMVQSGAAWVYERYNTDKSLPALQREAQEQKRGLWADSNPV
                     PPWEWRHKQN"
     CDS             3611..4873
                     /locus_tag="ctg1_47"
                     /transl_table=11
                     /translation="MGKLTLVEQALRLHKEYYGEDNFGTVVKDCDYYPKVAEIFINRKN
                     RKIYSNLDIEPVASTVVHTGSSPVMAKAGRIKKLMFKDGSGAYRIHLGQNEVVHIIRFI
                     LNSKVRMEYAVGTTKSMSMLHNLCEAGRAKLNRSLPRKGIWKLGYYDGVYYHGKARKEE
                     IENAMRFSVHPKFDELENDFNQFFSDIDFYTRYGQSGMRKVLFTGPPGTGKTTIAKALG
                     AKYQDKYVFVYADDYFKDVCYAAAQKKIPVIIIAEEVDELYRADAGTLSFLDGADTPRN
                     VAGTYVIFSTNYPKRIDPRIRKRPGRIDRIISVGAFRTKAAAACAKMYLPEDVEIDLKE
                     LGAVLDRTTPAEIKEIINIAIGMIRGTKNELSVDVIKNARAFLKGTLDLSVQEADEDIE
                     EREELYKKNGAQPDYLSYLED"
     CDS             4877..5452
                     /locus_tag="ctg1_48"
                     /transl_table=11
                     /translation="MQYALFDGFERKFLLDALEFGVLKDWKENPVKELPDIDESAHPFH
                     VCYGGYLLNPGVSDSDISRKIKDQTGFWLAAIDDTRMDCHSIAYYDIHTLPLISCGHQK
                     IVPFTALIKADECIISKIASYSGFAVTAFLRIKDQDIATNILNREGIFAFNGCERRFRH
                     PVSEDNWQQVISEERAIRCAKRLIQCKG"
     CDS             5457..6398
                     /locus_tag="ctg1_49"
                     /transl_table=11
                     /translation="MRLFIAEKPAVANDIVKALGGNFTRHDGWFESDNAIVTNCFGHII
                     ESQPPENYNPEYKAWKVETLPLRLYPVKYQPVESAAKQVKTILELIRRGDVTEIVHAGD
                     PDDEGQLLVDEVLEYAGNTKPVKRVLINDNTLPAVKKALANLKDNRDFKGLYLKALARS
                     VADAVYGFSMTRAYTIPAKARGYQGVLSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMT
                     GVFQRGADVLRANWKPGEFAPLTDRKLLDKAWADGTAASLAGKPATVEAAATDDKKTAA
                     PLPFNLVRLQQYMNKKFKMTAQKNAGYYATTT"
     CDS             6559..7611
                     /locus_tag="ctg1_50"
                     /transl_table=11
                     /translation="MTAHTAIIPTSSVPDVNALSTDERNVYLAIAQHYLVQFMPEKAYQ
                     EVSVAIQCGDESFYARARKTTDSGFEAFLGAEITDEGESEDNDDSAFELLCKIRTGETL
                     TTKEVVVNEKKTTPLPLFTEASLLAALVRVADFVTDPTIKKLLKDKDKDKKDEHGGIGT
                     PATRAAILETLKKRNYITLEKGKLIPTDTGYALIDALPGIAVNPDMTALWSEKQSAIEN
                     GDLTVEQFINELYGELTGMISDVDLGKMKIEPVAPAGQFQHLDSPCPSCGKHIVIRPKG
                     YFCTGCEFKIWSEFSGKKITQAQAEKLVKSGKTDLIKGFKKKSGGTYDTVLVLEDKKTG
                     KLGFPARAKK"
     CDS             7608..7814
                     /locus_tag="ctg1_51"
                     /transl_table=11
                     /translation="MKTKQEWLFQLRKCTSRDTLEKVIEINRYKLPLSESEAFYSAADH
                     RRAELVMNKLYDKVPSGVWKYVH"
     CDS             7830..8294
                     /locus_tag="ctg1_52"
                     /transl_table=11
                     /translation="MSELTKEDEYGIISRTMMNIRSLRVFAREIDFEQLLEMQEKLNVV
                     IEERREDAEREAAERAERERKRQELLQLIAGEGFSPEELLGLSEEAPKLRKKTLPKAPP
                     KYQFEENGETKYWSGRGRAPKPIAEALAGGRSLDEFIIKKDASSSAGDEQ"
     CDS             8349..8756
                     /locus_tag="ctg1_53"
                     /transl_table=11
                     /translation="MSLTLPLMYFQTGADLSKITHHEVHYQDGFVQQAWLQPEIQLFVV
                     CIARKKGSRREIKGGMAVLTSIPASNGAELAKALDNVMRQSDELRPLAGKDENVFIPAR
                     IGISGEEPPTEQELLSVFYQQCLKHGSWGSA"
     CDS             8964..9299
                     /locus_tag="ctg1_54"
                     /transl_table=11
                     /translation="MIAVDTEENVFIAESGNEYDGAKCWVVDDDDSHRTRYSELQQAFD
                     FYNQRLFDGELPECLITFQRVTLELFQGKFALSWFDRFPVQVEQQKEMAAVIDQWRETT
                     CSSTSKC"
     CDS             10001..11053
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_55"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 1.9e-19,
                     bitscore: 61.5, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="ThiF (E-value: 9.3e-48, bitscore: 154.5,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYILGRYVKIARYGSGGLVGGGGKEQYVEDLALWENIIKTAYCF
                     ITPSSYTAALGTVNIPEKDFSNCFRFLKENFFIIPGEYNNSTENNRYSRNFLHYQSYGA
                     NPVLVQDKLKDAKVVILGCGGIGNHVSVILATSGIGEIILIDNDQIENTNLTRQVLFSE
                     NDVGKNKTEVIKRELLKRNSEISVSEIALNINDYTDLHKVPEADIWVVSADHPFNLINW
                     VNKYCVRANQPYINAGYVNDIAVFGPLYVPGKTGCYECQKVVADLYGSEKENIDHKIKL
                     INSRFKPATFAPVNNVAAALCAADVIKFIGKYSEPLSLNKRIGIWSDEIKIHSQNMGRS
                     PVCSVCGNRM"
     CDS             11050..12102
                     /locus_tag="ctg1_56"
                     /transl_table=11
                     /translation="MNTANILSVNYGAYNAIRMLIGVYHAAFLISTGVTISQLAVLQIV
                     FSVTVLILDFPLSVIADRFYRKQVVVSGVFFTILFYPLCIQSPDMLALVFSEIFYAIGI
                     CCISGAIEGWVLSALDGRNEKFTLCAHLCERVSSFGSVITGAVGILVVYFYDSYKSGYI
                     VSFFLMFVVFIVFLCVKTNGSGGEKEARDSIIKQAKESIGLITGSYNGTYFLSITCMFT
                     LGIQVIYHFWQPIMLSGESIGSLSKRELITLLMCHIGAFSMQYIANYLMPKIDVRCKLY
                     ILVCTLCSFLSSIACILLFMLITDNNVVLGVAIFSIIHGMISTIPVGAQNIFISRLNGN
                     YKNIISGALGL"
ORIGIN
        1 ttcgtaaatg tactgatggt aatgatttcg atctccgtca gttgcgacgg gaagatatca
       61 ctgtttatgt cggtgttaat gcggaagata tatctctggc ttacgatttt ctgaacctgt
      121 ttttcaactt cgttgttgaa gtgacattgc gtgaaaatcc tgattttgat cccaccctga
      181 aacatgactg cctgatgttt cttgatgagt tcccttcgat tggttatatg ccaattatta
      241 aaaaggggtc agggtatatt gcaggtttta aacttaaact gctgacgatt tatcagaata
      301 tcagtcagct aaatgaaatc tatggtattg agggagccaa aacgctgatg agtgctcatc
      361 catgccgtat tatctatgct gtcagcgaag aggatgatgc cgcgaagata tcagaaaaac
      421 ttgggtatat tacaaccaca tcaaagagca caagcaagag ccggggacga tcagcttcac
      481 agggcgaatc agaaagtgaa gcccgaagag cactggtgct tccacaggag ctgggaacgc
      541 tggactttaa agaagaattt atcatcctga agggggagaa ccctgttaaa gcagaaaagg
      601 cactttatta ccttgatccg tattttatgg acaggttaat gaaggtcagt cctaaactgg
      661 catcattgac gatggaacta aataagacga aaaaaatatt tggtgtgaaa gggcttaaat
      721 atccgtcaaa agaaaaaatg ctctccgtag gggagctgga gtctgaggtt ttgctatgaa
      781 aaaatactta tgatcagtat tcttctcctc acagcctgtt cctctccacc tgaaccgcca
      841 caggttgaat gggaaaaaac gcctgaagtt atgaatacac aaataatgaa ctggaaacca
      901 acatccggtg ttattaaatc agataatata aattccttat ggagtaaggt gttgcctgat
      961 tttaaaccag aaaaccgtct ttacgatgat tctgtttttt atgccgttgc ccattctgaa
     1021 aaaatagttg taaggacatc ttcttttgat aattactggt cagcgaaaga ctggctaaga
     1081 aaaaatggtg caacaggtgt tattgaatat cagccactaa aaagatggtt gaataatgac
     1141 tatgttgaaa tttatctgtc aagaataaat attcagaggt tactatgaaa aggatatgca
     1201 aaggtctaat cgtaattttt actgtgtcct tgtttacagc gccaacgtat gccgctgatc
     1261 cctgtaaatc cgttttttgt ctttatggta aagctgtcgg tagtagtgga gggagtgagt
     1321 gcagtagtgc agaaaaggat ttttttaaaa atgttgaaaa gaaaaagggg aaaatccgct
     1381 ggggtaaaac atttgatctc cgtaagaatt ttttaaatca gtgttcaact gcagacccgg
     1441 ctgcaatctc actgatcatg agtaagtttg gtcgcgtcag aggctgatta aaacctgata
     1501 cccgcgccaa cgggtatcag gtgactgcaa gtatcacatg ccgcgtcaac ggaatgtgat
     1561 tattagttac aatcaaaggt gtcaaaaatg aaagtaacca agtctattat agttatttta
     1621 ttgggttcac tgggactgtt ttctggtagc tcatatgcat catgcaccta tcatctgact
     1681 ggtaattctg aaaccattga cctttcagga tgtgttgcga ctgccgaaaa taccgcaaat
     1741 acagccagct caactgcatc gaacgcatta acaatcgcgc aaaaggcaca aactacagcg
     1801 gatactgcaa acaccactgc acaatccgca cagacgaccg caaatgaggc cagttcagcg
     1861 gcacagaacg ccctgaatgc agctaatacg gcacaaacta cagcggatgc tgcaaatact
     1921 gccgcacagt cagcgcagac aaccgccaac caggcaatcc aggatgcggc agaaaaagct
     1981 gaagcggcag aagagaacgc aaacaactat acagacaata aaattacgga tgctaaaaat
     2041 gaactgaata cgaatattga tagtgcgaaa aatgacgcga tcaattcatc gaacagttac
     2101 actgacagca aaataggtga cacgaagaca gaactgaacg ccagtatcga taaggcaaag
     2161 aacgacgcga tcagctcatc aaatagctac accgacaata aaatcagtga tacgaaaaca
     2221 gaactgaata ccagtatcga caatgcaaaa aatgaggcaa tcagcacatc aaacaactat
     2281 acggataaga aatatcaaca aggtatacag tatgctcaga atgcagccga taaagctgaa
     2341 caaaatgcga ataactacac agataaccgg ttcagtcagt taagcaatca atcaaatcag
     2401 cggttcgaac aattaaacag taaaattgaa cgtgcggaaa aacgtcttaa tgccggtatt
     2461 gcaggtgtaa cagcaatatc atcaatcccg tatgttgctg aaaatagttt ctcatatggt
     2521 attggtgttg gtaattatca gaatggaaat gcgattgcag caggcattca atataaaacg
     2581 tcattaaaca caaacgtgcg tcttaacgtt tcatgggatt catctcataa cactgttctt
     2641 ggcgcaggtt ttgcgggtgg ctggtaataa acatatctac atatgtgaaa ggagataaaa
     2701 atgaaaccat tagtttatgc agtaattctg tcactgacga ccttttctgc ttttgcaaaa
     2761 cagaactcgg ctaacagtca gaaaactggt gcaagtaata ttgaaagaca aagctatgag
     2821 aataccgatg cggggaaaaa acaagctgaa tggatgaaag gtaaattagt taaatctgat
     2881 tgttctccag ccatgaaccg tattggctgg tcagaaggtt gtaagtaatc atcaatgata
     2941 acctcgcaga ttccagattt taatctggat tttgcggggt tgaacaaccg aagggcgtta
     3001 gtattttatg aaaattatat taataacatt tatttttctg tttactgttt ttcagtctgc
     3061 aaatgcaggt ggaatacctg gtgttttcac attaaacctg gaaattcagg ggaaagttat
     3121 tcgcgttctc gatggcgaca ccatagaagt taaaacacta cccgcaaaaa ttgttgtgta
     3181 tgaagttccg attcgggtcc gattgataaa catcgatgcc cctgaaaaga aacaaccttt
     3241 tggacgctgg tcaagaaatc aacttaaagc cttgctcgcc ggacaatccg ttactgtctc
     3301 ttatacgcaa acagatcgct acggccgcat tgtcggtcgc gtgttcacga cgaacggcac
     3361 ggaggccagc cgcttcatgg ttcagtctgg cgctgcgtgg gtatatgaac gttacaacac
     3421 agataaatca ttaccagctc tgcaacggga agcgcaggaa caaaaacgag gtttatgggc
     3481 tgacagtaat ccggttccac cgtgggaatg gcgacataaa cagaactgac gcgcgttgct
     3541 tgtccaaccc ctccactacc ttaaataaat ttcaggcagt gtcacggttt taaatataca
     3601 tggtgcgctt atgggtaaat taactctggt agagcaggct ttacggcttc acaaagaata
     3661 ttacggtgaa gataattttg gaactgtcgt aaaggattgt gattactatc ctaaagtggc
     3721 agagattttt ataaacagaa agaaccgtaa aatttattcg aatctggata tcgaacctgt
     3781 tgcttcaacc gttgttcata cgggaagtag ccctgttatg gctaaagccg ggagaattaa
     3841 aaaacttatg ttcaaagatg gttctggtgc atacaggatt catcttggtc aaaatgaagt
     3901 tgttcatatt attcgcttca ttcttaactc taaagtcagg atggagtacg ccgttgggac
     3961 tactaaaagt atgtcaatgc tccacaatct ttgcgaggca ggtcgcgcta aattaaaccg
     4021 ctcattacca cgtaaaggta tctggaaact tgggtactat gatggtgttt attatcacgg
     4081 taaggcaaga aaggaggaaa ttgaaaatgc tatgcgtttc tcagttcatc caaaatttga
     4141 cgagctggaa aacgacttta atcagttctt ttctgatatt gatttctata cccggtatgg
     4201 tcagtcaggt atgcgtaaag tgctctttac tggcccccca ggaacaggca agacaactat
     4261 cgcaaaagct ttgggggcaa agtatcagga taagtatgtt tttgtttatg ccgacgatta
     4321 ctttaaagat gtttgctacg ctgctgctca gaagaaaata cccgtcatta ttatagctga
     4381 agaggttgat gaactttatc gggctgatgc cggaacgtta agttttcttg atggagctga
     4441 tacaccgcga aatgtcgcag gaacatatgt gatcttttct acaaactatc caaaacgtat
     4501 cgacccacgt attagaaaac gtccaggtcg aattgacagg ataatctctg taggtgcttt
     4561 cagaaccaaa gccgctgccg cttgcgccaa aatgtactta ccagaagatg tagaaattga
     4621 ccttaaagag cttggcgcag tgctggacag aacgactccg gctgaaatca aggaaattat
     4681 taatatcgca atcggaatga ttcgcggaac caaaaatgaa ttatcagtgg atgtaataaa
     4741 aaatgctcgt gcctttttga aaggaaccct tgatctgagc gtgcaggaag cagatgaaga
     4801 tatagaggaa agggaagagc tttataaaaa gaacggggcg caacctgact atttaagtta
     4861 cctggaggat taacacatgc aatatgcatt gtttgatgga tttgaacgaa agtttttgct
     4921 ggatgctctt gaatttggtg ttctgaaaga ctggaaagaa aatccggtaa aagaacttcc
     4981 tgatattgat gaatctgctc accccttcca tgtctgttat ggtggatatt tattaaaccc
     5041 tggtgtgtca gattctgata ttagcagaaa aataaaagac cagacaggat tctggctggc
     5101 agctattgat gatacccgta tggattgtca ttcaatagct tattatgata ttcacaccct
     5161 ccctttaatt tcgtgtggtc atcagaagat agttcctttt acagcgttaa taaaagctga
     5221 tgaatgcatc atttcaaaaa ttgcttcgta ttctggtttt gccgtaacag cctttttgag
     5281 aattaaagac caggatatcg caacgaatat acttaaccgt gaggggattt ttgcttttaa
     5341 tggctgtgaa cgcagattca gacatccagt aagtgaagat aactggcaac aggtaatatc
     5401 agaagaacgt gctatccgtt gtgcaaaaag attaattcaa tgtaaaggat aacaaaatga
     5461 gactttttat cgcagaaaaa cccgcagtag caaatgatat tgttaaggca cttggtggca
     5521 attttacccg ccatgatggc tggtttgaaa gtgataacgc cattgtgacg aactgttttg
     5581 gtcatattat cgaatcacaa ccgccggaaa actataatcc tgaatacaaa gcctggaagg
     5641 ttgaaacgct tcctttacgt ctttatcccg tgaagtatca gcctgttgaa agtgcagcaa
     5701 aacaggttaa aacgattctc gaacttatca gacgtggaga cgtgactgaa attgttcacg
     5761 ctggcgatcc tgatgatgag ggacagctac ttgttgatga agtcctggaa tatgcaggaa
     5821 acacaaaacc cgtgaagcgc gttctgataa acgacaacac gcttccggca gtgaaaaagg
     5881 cactggcaaa tcttaaagat aatcgtgatt tcaaagggct ttaccttaag gcgctggcgc
     5941 gttcagttgc cgatgccgtc tatggattct ccatgacgcg tgcttacacc attcctgcaa
     6001 aagccagagg atatcagggc gttctgtctg tcgggcgcgt ccagacaccc gttcttggcc
     6061 tgattgtgaa tcgtacccgt gctaaccaga accataaatc cagtttttac tacaccatga
     6121 ccggagtttt tcagcgtggt gctgatgttc tcagggcgaa ctggaaacca ggtgaatttg
     6181 ctccgctgac cgaccgtaaa ttacttgata aggcgtgggc agacggaacg gcagcatccc
     6241 ttgcaggaaa accggctaca gttgaagcag cagcaactga tgataaaaaa acggctgcgc
     6301 cgttgccgtt taacctggtc agactccagc aatacatgaa caagaagttt aaaatgacgg
     6361 cacaaaaaaa cgctggatat tacgcaacaa ctacgtgaaa aatataaagc aattacttat
     6421 aaccgctcag attgctcata tctttctgat gaacaattca gtgaagcgcc gcaggttatc
     6481 gatgccctga aatcagtctt tcctcagtcg ctggatattg attcttcacg taaaagcaaa
     6541 gcgtttaaca gtgcaaaggt gactgcgcat actgcgataa tcccgacctc cagtgtgcct
     6601 gatgttaacg cactcagcac cgacgagcgc aatgtttacc tggcgatcgc acaacactat
     6661 cttgttcagt tcatgcctga aaaagcatac caggaagtat cggttgccat tcagtgtggt
     6721 gatgagtcgt tctatgcccg tgccagaaaa acaactgaca gcggatttga ggcgtttctt
     6781 ggcgcggaaa tcacagacga aggtgaatca gaagataatg atgattccgc ttttgaactg
     6841 ctctgtaaaa ttcgcacagg agaaacactg acgacaaaag aagttgttgt taatgagaag
     6901 aaaacaacac cgctgccgtt attcaccgaa gcctccttgc ttgctgcgct tgttcgtgtc
     6961 gcggattttg tcactgatcc aacgattaaa aaattactga aagataagga taaagacaaa
     7021 aaagatgaac atggcggtat tggtacgcca gctacccgtg cagccattct ggaaacgctg
     7081 aagaagagaa actatatcac gctggaaaaa gggaaactta ttccgactga taccggatat
     7141 gcgcttattg atgccctgcc aggtatagcg gttaatcctg atatgacagc attatggtct
     7201 gaaaaacagt ctgccattga aaatggcgac ctgacggttg aacagtttat taatgagctg
     7261 tacggtgaac tgacaggcat gatttctgat gttgacctgg gcaagatgaa gattgaaccc
     7321 gttgcgccag cagggcagtt tcaacacctg gactctccct gcccttcctg tggtaaacat
     7381 attgttatca ggccgaaagg ttatttctgt accggatgtg aatttaaaat ctggagtgag
     7441 ttttctggta agaaaatcac ccaggcacag gccgaaaaac tggttaaatc agggaaaacc
     7501 gatttgatta agggatttaa aaagaaaagt ggtggaacgt atgatacagt tcttgtcctt
     7561 gaggataaga aaacagggaa gctgggtttt ccggcaaggg ctaagaagtg aaaacaaagc
     7621 aggaatggct ttttcagtta agaaaatgta catcaagaga tactcttgaa aaagttattg
     7681 agattaaccg ttacaagctg cctttatcag aatcagaggc attttattct gccgcagatc
     7741 accgccgtgc agaactggtg atgaataaac tttatgataa ggttccttcc ggcgtatgga
     7801 agtacgtcca ttaaacaaga ggattaatta tgagcgaact gactaaagaa gatgaatacg
     7861 gcattatcag ccggactatg atgaatattc gttcattgcg tgtgtttgcc cgtgagattg
     7921 attttgagca gttgctcgaa atgcaggaaa agctcaacgt tgttattgaa gaacgtcgtg
     7981 aagatgctga acgtgaagcg gctgaacgag cagagcgtga acggaaacgt caggaactgc
     8041 ttcagttaat cgccggagag ggtttctcac cggaagaact gcttggtctg tccgaagaag
     8101 caccaaaatt acgtaaaaaa acgttaccaa aagcgccacc caagtatcaa tttgaagaaa
     8161 atggtgaaac gaaatactgg tctggtcgtg gacgtgcgcc aaaaccgata gctgaagcac
     8221 tggcaggcgg tcgctctctt gatgagttta tcatcaaaaa agatgcttcc agctctgctg
     8281 gcgacgaaca gtaatataat aagcttctgg tttacgcagg agactttttt gataaacagg
     8341 aggatgtttt gagtctgaca ttaccattaa tgtatttcca gacaggtgca gatctcagca
     8401 aaatcacaca tcatgaagtg cactatcagg acggctttgt tcagcaggca tggttgcaac
     8461 ctgaaataca gctatttgtt gtgtgtatcg ccaggaaaaa aggctcccgt cgcgagatta
     8521 aaggtggaat ggccgttctt accagtattc cggccagcaa tggagcggag ttggcaaaag
     8581 cgttggataa cgttatgcgc cagtctgatg agttgcggcc actggcaggg aaagacgaaa
     8641 acgtatttat cccagccaga attggaattt ctggcgaaga accgccaaca gagcaagagc
     8701 ttctaagtgt cttttaccag caatgcctga aacatggctc atggggcagt gcctgatttc
     8761 tggtacataa agcagggata ccccctgctt acctttcttg ccagcaatat tacgcgctcg
     8821 atgctcttcc taggcttgat attgccaggg tatggcgtca gcacaacccg gagcacgcag
     8881 attcgggtgt gattctgatt tgggacggga aggtgtattg ctggaaaaat attctccgcg
     8941 cccctcagca tgagcgcccc agagtgatag cggtagatac tgaagagaac gtgtttattg
     9001 cagaaagtgg caatgaatat gacggcgcga aatgctgggt tgtcgatgat gacgatagcc
     9061 acagaacgcg ctacagcgag ctacaacagg catttgattt ctataaccag cgcctttttg
     9121 acggtgaact ccccgagtgt ctgattacgt tccagcgcgt cacactggaa ctgtttcagg
     9181 gtaaatttgc tttgagctgg tttgatcgct tccctgtcca ggttgaacaa caaaaagaga
     9241 tggccgccgt catcgatcaa tggcgggaaa ctacttgctc aagcacatca aaatgctgaa
     9301 ccgggattga tatcgaagcc ggtgctgtca gtgtcaccgt agaacgggag caatgataac
     9361 gatctgtttg ttgcggcttt tgaggacaag ctaaaaagga acaaagtcaa atatcagtgt
     9421 cggggtgtgg tgctgctgtc tgggggaagt ccggagtgaa tattgaatgc ggtgattgcg
     9481 agctgccttt catcgaaaat taatctccat tttcgtggca tttcctgatt ctttctcata
     9541 aattctcgtg tccaatccga cccgaaaaac ctcagatttc acgtagcgca ccaccgctca
     9601 ttgagtggct tctcaacgtg actggtaatc aggattattg gtttctaatg taatgaacga
     9661 tggatgtatc aaatttttat tacaaaatgg tttaaacgta gatgattata ttctgtatgg
     9721 ttatttatgt ctaaatatat aaattaataa attttagaat aaaaatgtat aaccgcaaat
     9781 aatatgattg tgctgttctt tttttgtgaa atgaatctat gtttgtatat tttcatgagg
     9841 aatattgttt tttatagtga taaaaacact tgtgaattaa tcacagtaat aggaggcgta
     9901 gaatgcgtac tggtaatgca aactaatggc aaaatataaa tgtccattaa atgccaccct
     9961 gtacagggtg gcatacaaaa tttatctgcg aggtttattt atggattata tattgggtcg
    10021 ctatgtcaaa attgctcgat acgggagcgg tggattagtt ggtggaggcg gaaaggagca
    10081 atatgttgag gatttagcgc tttgggaaaa tattataaaa accgcatatt gtttcataac
    10141 cccatcgagt tatactgcag cgttgggaac tgtcaatata cctgaaaaag atttctctaa
    10201 ttgctttagg ttccttaagg aaaatttctt tattatacct ggtgagtata ataactctac
    10261 tgagaataat cgttactctc gtaacttttt acattatcaa agttatggtg ctaaccctgt
    10321 tcttgtgcaa gataaactaa aagatgctaa ggtagtaatt cttggttgtg ggggtatagg
    10381 aaatcatgta tctgttatac tcgcaacgtc tggtattggc gaaattatac taattgataa
    10441 tgatcaaata gaaaatacaa atttgacaag gcaggtttta ttttcagaga atgatgtcgg
    10501 taaaaataaa acagaagtta taaaacgcga gttattaaaa agaaactctg aaatttcggt
    10561 gtctgagatc gctttgaata taaacgatta cactgatctt cataaggtac cagaagctga
    10621 tatatgggtt gtttctgcag atcatccatt taatctgatc aactgggtta ataaatattg
    10681 cgttagagca aatcagccct atataaatgc tgggtatgtt aatgatattg cagtctttgg
    10741 tccattatat gttcctggta aaacaggatg ttatgagtgc caaaaagtcg tggcagatct
    10801 atatggttca gaaaaggaaa acattgatca taagattaag ctaatcaata gcagatttaa
    10861 accagcaaca tttgcacctg tgaataatgt tgccgctgca ttatgtgcgg cagacgtaat
    10921 taagttcatt ggaaaatact ccgagccatt atcacttaat aaaagaatag gcatctggtc
    10981 agatgaaata aaaatacatt cccaaaatat gggccgttcg cctgtttgct ctgtgtgtgg
    11041 aaatagaatg tgaatactgc aaatatttta tctgtgaact atggagctta taatgctata
    11101 cgtatgttaa ttggtgtcta ccatgcagca tttcttatat ctacaggtgt cactatatct
    11161 caacttgctg ttttacagat cgttttttct gtgacagtgc tgatccttga ttttccttta
    11221 tctgtcattg cagacagatt ttacaggaaa caggttgtag ttagtggcgt attttttact
    11281 attttatttt accctctttg tattcagtct cctgatatgc tggcattggt tttttctgaa
    11341 atattttatg ccattggtat ttgttgtata tctggggcta tagagggatg ggtgttaagt
    11401 gctctggatg gtagaaatga aaaatttacc ttatgtgctc atttatgcga aagggtatct
    11461 tcctttggga gtgtgataac tggtgctgtt ggaatattag ttgtctactt ctatgattct
    11521 tataaatctg gctatatagt atcgttcttc ttgatgtttg ttgtctttat cgttttttta
    11581 tgtgtaaaaa ctaacggcag tgggggtgaa aaagaagcac gagatagtat tattaaacaa
    11641 gcaaaagaga gtattggatt gataacagga agttataatg ggacatattt tttatctata
    11701 acatgtatgt ttacacttgg tatacaggta atttatcatt tttggcagcc aattatgtta
    11761 tccggggaaa gtattggctc attatcaaaa agagagctta taactttact gatgtgtcat
    11821 attggtgcat tttcaatgca atatatagca aactatctta tgccaaagat agatgtaagg
    11881 tgtaaacttt atatacttgt ttgtacatta tgttcatttc ttagttcaat cgcctgtatt
    11941 ttactattta tgttaataac agataataat gttgttctcg gtgtagctat tttctctata
    12001 atccatggga tgatttcaac aatacctgtt ggagcacaga atatattcat aagcagactt
    12061 aatggcaatt ataagaatat tatttcggga gctcttggtc ttgt
//
