LOCUS       NZ_CP076346.1          13372 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP076346.1 Escherichia coli strain AVS0096 plasmid pAVS0096-b,
            complete sequence.
ACCESSION   NZ_CP076346
VERSION     NZ_CP076346.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-06-07 23:25:39
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13372
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..324)
                     /locus_tag="ctg1_1"
                     /transl_table=11
                     /translation="MAQKITPSKIVKHARELIIKGIESGDNSFVIFDVDGALERLEHYR
                     CQLKSFFPNSSIAYSYKSNNLAQWCQIISGKGLYAEVCSVDEMNLAKRDGFNRIVFDGP
                     LKKT"
     protocluster    1..13372
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2319:3372]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2320..3372
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13372
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13372
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(309..1112)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 60.2; E-value:
                     3.5e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2"
                     /transl_table=11
                     /translation="MTIKHAEELTEEVILNMNYPDFVALMQQDNTPPGAEYTIDYWIKH
                     GCINKKSHLLDLACSTGFSSRECFKKEGASAEGIDISESAVMVANEKAKKLKANNLLKY
                     YVADACDLPFEDNSFTHVLGGCNFAFIQNRLIALNETHRCLNHMGSMCISNFYYRRKIS
                     DKLINDVYNAINFRPNPLWTLEYWYQFFSERFTLVSEENHEMESQSEDELKADIYDYIF
                     NRNEFTKGLNGSLQNVFFERFLKIRRPLNIQRDYQGVTLQIWRKK"
     CDS             complement(1109..2323)
                     /locus_tag="ctg1_3"
                     /transl_table=11
                     /translation="MNTANILSVNYGAYNAIRMLIGVYHAAFLISTGVTISQLAVLQIV
                     FSVTVLILDFPLSVIADRFYRKQVVVSGVFFTILFYPLCIQSPDMLALVFSEIFYAIGI
                     CCISGAIEGWVLSALDGRNEKFTLCAHLCERVSSFGSVITGAVGILVVYFYDSYKSGYI
                     VSFFLMFVVFIVFLCVKTNGSGGEKEARDSIIKQAKESIGLITGSYNGTYFLSITCMFT
                     LGIQVIYHFWQPIMLSGESIGSLSKRELITLLMCHIGAFSMQYIANYLMPKIDVRCKLY
                     ILVCTLCSFLSSIACILLFMLITDNNVVLGVAIFSIIHGMISTIPVGAQNIFISRLNGN
                     YKNIISGALGLVSLSCRVASISVLGVISVLPGNMPVTTYIFISAIACVLCGCLFLMWSF
                     KKEMV"
     CDS             complement(2320..3372)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_4"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 2.1e-20,
                     bitscore: 64.5, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="ThiF (E-value: 8.8e-48, bitscore: 154.5,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYILGRYVKIARYGSGGLVGGGGKEQYVEDLALWENIIKTAYCF
                     ITPSSYTAALETVNIPEKDFSNCFRFLKENFFIIPGEYNNSTENNRYSRNFLHYQSYGA
                     NPVLVQDKLKDAKVVILGCGGIGNHVSVILATSGIGEIILIDNDQIENTNLTRQVLFSE
                     NDVGKNKTEVIKRELLKRNSEISVSEIALNINDYTDLHKVPEADIWVVSADHPFNLINW
                     VNKYCVRANQPYINAGYVNDIAVFGPLYVPGKTGCYECQKVVADLYGSEKENIDHKIKL
                     INSRFKPATFAPVNNVAAALCAADVIKFIGKYSEPLSLNKRIGIWSDEIKIHSQNMGRS
                     PVCSVCGNRM"
     CDS             complement(4617..5024)
                     /locus_tag="ctg1_5"
                     /transl_table=11
                     /translation="MSLTLPLMYFQTGADLSKITHHEVHYQDGFVQQAWLQPEIQLFVV
                     CIARKKGSRREIKGGMAVLTSIPASNGAELAKALDNVMRQSDELRPLAGKDENVFIPAR
                     IGISGEEPPTEQELLSVFYQQCLKHGSWGSA"
     CDS             complement(5079..5543)
                     /locus_tag="ctg1_6"
                     /transl_table=11
                     /translation="MSELTKEDEYGIISRTMMNIRSLRVFAREIDFEQLLEMQEKLNVV
                     IEERREDAEREAVERAERERKRQELLQLIAGEGFSPEELLGLSEEAPKSRKKTLPKAPP
                     KYQFEENGETKYWSGRGRAPKPIAEALAGGRSLDEFIIKKDASSSAGDEQ"
     CDS             complement(5559..5765)
                     /locus_tag="ctg1_7"
                     /transl_table=11
                     /translation="MKTKQEWLFQLRKCTSRDTLEKVIEINRYKLPLSESEAFYSAADH
                     RRAELVMNKLYDKVPSGVWKYVH"
     CDS             complement(5762..7915)
                     /locus_tag="ctg1_8"
                     /transl_table=11
                     /translation="MRLFIAEKPAVANDIVKALGGNFTRHDGWFESDNAIVTNCFGHII
                     ESQPPENYNPEYKAWKVETLPLRLYPVKYQPVESAAKQVKTILELIRRGDVTEIVHAGD
                     PDDEGQLLVDEVLEYAGNTKPVKRVLINDNTLPAVKKALANLKDNRDFKGLYLKALARS
                     VADAVYGFSMTRAYTIPAKARGYQGVLSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMT
                     GVFQRGADVLRANWKPGEFAPLTDRKLLDKAWADGTAASLAGKPATVEAAATDDKKTAA
                     PLPFNLVRLQQYMNKKFKMTAQKTLDITQQLREKYKAITYNRSDCSYLSDEQFSEAPQV
                     IDALKSVFPQSLDIDSARKSKAFNSAKVTAHTAIIPTASVPDVNALSTDERNVYLAIAQ
                     HYLVQFMPEKAYQEVSVAIQCGDESFCTRARKTTDSGFEAFLGAETTDVGESEDNDDSA
                     FELLCKIRTGETLTTKEVVVNEKKTTPPPLFTEASLLAALVRVADFVTDPTIKKLLKDK
                     DKDKKDEHGGIGTPATRAAILETLKKRNYITLEKGKLIPTDTGYAIIDALPGIAVNPDM
                     TALWSEKQAAIENGDLTVEQFINDLYGELTGMISDVDLGKMKIEPAAPAGQFQRLDSPC
                     PSCGRHIVIRPKGYFCIGCEFKIWSEFFGKKITQAQAEKLVKSGKTDLIKGFKKKSGGT
                     YDTVLVLEDKKTGKLGFPVRAKK"
     CDS             complement(8002..8304)
                     /locus_tag="ctg1_9"
                     /transl_table=11
                     /translation="MKKICKSLIVIFTVSWLTAPAYASDPCASVLCLYGKAVGQGGGSE
                     CSSAEKDFFNKIEKKKGKIRWSKTFNLRKNFLNQCSTADPAAILLIMSKFGRVRG"
     CDS             complement(8301..8714)
                     /locus_tag="ctg1_10"
                     /transl_table=11
                     /translation="MKKILMISILFLTACSSPPEPPQVEWEKRPEVMNTQIMNWKPTSG
                     VIKSDNINSSWSKVLPGFKPENRLYDDSVFYAVAHSEKIVVRTSSFDSYWSAKYWLRKN
                     GATGVIEYQPLKRWLNSDYVEIYLSRINVQRLP"
     CDS             complement(8711..10546)
                     /locus_tag="ctg1_11"
                     /transl_table=11
                     /translation="MSLKLPDKGQWFFIGLVMCLVTYYAGSVAVYFFNGKTPLYIWKNF
                     DSMLLWKIITESNIRTDIRLTAIPSLLSGMVSSLIVPVFIIWQLNKMDVALYGDAKFAS
                     DNDLKKSKLLKWETENDTDILVGAYKGKYLWYTAPDFVSLGAGTRAGKGAAIGIPNLLV
                     RKHSLIALDPKQELWKITSKVREILLGNKVYLLDPFNSKTHQFNPLFYIDLKAESGAKD
                     LLKLIEILFPSYGMTGAEAHFNNLAGQYWTGLAKLLHFFINYEPSWLNEFGLKPVFSIG
                     SVVDLYSNIDRELILSKREELEETNGLDENALYHLRDALTKIREYHETEDEQRSSIDGS
                     FRKKMSLFYLPTVRKCTDGNDFDLRQLRREDITVYVGVNAEDISLAYDFLNLFFNFVVE
                     VTLRENPDFDPTLKHDCLMFLDEFPSIGYMPIIKKGSGYIAGFKLKLLTIYQNISQLNE
                     IYGIEGAKTLMSAHPCRIIYAVSEEDDAAKISEKLGYITTTSKSTSKSRGRSTSQGESE
                     SEARRALVLPQELGTLDFKEEFIILKGENPVKAEKALYYLDPYFMDRLMKVSPKLASLT
                     MELNKTKKIFGVKGLKYPSKEKMLSVGELESEVLL"
     CDS             complement(10549..11580)
                     /locus_tag="ctg1_12"
                     /transl_table=11
                     /translation="MNNENRHLIYDVVNDYFYHWLNEIDGVTEIAVNRPGEIFIKVRGK
                     WQWYEQKMSYSDCLSFASTLADFHDGGSVTPEYPLRSATLPGGERVQVVIPPATEKDTV
                     SITIRKPSGIFISHDKFIKQGFYSRVSGLSGDSVMEDNISALITSGYFERVIPESLRQG
                     KTIVFCGGTGSGKTTFANACLEYIPHHLRCISIEDTDEAKFRFHKNHVKLYYPAEGESK
                     VITSASLLRSCFRMNPDRILMTEIRGAEAWDFLKASSSGHAGNITTVHESSPEYAVLGI
                     VQRCYMNPECQNLPFNVILRRVLSNIDIIMSIKYLDDEDFRFASGIYYRQLHFDDYFRK
                     LKE"
     CDS             complement(11582..12787)
                     /locus_tag="ctg1_13"
                     /transl_table=11
                     /translation="MTEQENKIPTATEIEQQLRERRQKELEQAGKTPEEEPGKPALQLG
                     IEKLKKSRKGMIILVVGFLLLAAGVSVYYIPSIIRSVSSGDEKPASQPLATGAAKRQTG
                     LSEDIDPFNTAQKKTEKPEEEKVISSEKTEPPENKQQSFSRALDVSLDGSQAGNSSSSA
                     GTSVSHTAASELESDKKDEAKATAQTTESAPLAKITKLPYDPNLFIPEGTSIPCSLDRR
                     FVSDLAGKLECTVNSDIYSASGNVKLIERGTAAKLMYKAGTLRHGQGRVFVMAYKLRTR
                     SRPFIDIPLIDSQAAGALGEAGASGWIDTHFGERFLGAMMVGMIPDLSQAASGIAQNNR
                     DSQTDYTANSRQAFSDIAREAFSNSVNIPPTLYKNQGEIITLIVGQDLDFSGIYKLKMK
                     GG"
ORIGIN
        1 cgtttttttt aaagggccat caaaaacaat ccggttaaaa ccgtctcttt tagcgaggtt
       61 catttcatca acagagcaca cctctgcata caaaccttta cctgagataa tctggcacca
      121 ttgtgccaga ttatttgact tatatgaata tgcgatactg ctgttgggga aaaaactctt
      181 aagttgacac ctgtaatgtt ccagacgctc cagagctcca tctacatcaa aaatgacaaa
      241 tgagttatca cccgattcaa tccccttaat aattaactcc cgggcatgtt taacaatttt
      301 agatggtgtt attttttgcg ccatatttgc aatgtaactc cctgataatc tctttggata
      361 tttaatggtc tgcgtatttt taaaaatctt tcaaaaaata cattctgaag tgaaccattc
      421 aaaccttttg taaactcatt tctattgaaa atgtaatcat aaatatcggc ttttaactca
      481 tcttcacttt gagattccat ctcatgattt tcttctgaaa ccagagtaaa tctttcagaa
      541 aaaaactgat accagtattc caaagtccac aaaggattgg gtctgaaatt tattgcatta
      601 tatacatcat tgataagctt atctgatatt ttacgcctgt aataaaaatt tgaaatgcac
      661 atgcttccca tgtggtttaa acatcgatga gtttcattca aagctattaa ccgattttgt
      721 ataaatgcaa aattacatcc accgagaaca tgtgtaaaag agttatcttc aaatggtaaa
      781 tcacaagcat cagctacata atatttcaat aaattattag ccttaagctt ttttgccttt
      841 tcatttgcga ccattacagc tgattcagat atatcaatac cctctgcaga tgcaccttct
      901 tttttgaagc attcacgtga actaaaaccc gtggaacatg ctaaatctaa taggtgagac
      961 tttttgttaa tacatccatg cttaatccag tagtctatgg tgtactctgc tccaggagga
     1021 gtgttatcct gttgcatcag agcaacaaaa tcagggtaat tcatatttaa aatgacttct
     1081 tccgtcaatt cttcagcatg tttaatcgtc ataccatctc ctttttaaag gaccacatta
     1141 agaacaaaca accacacagt acacatgcaa ttgcagagat aaatatataa gtggtgacag
     1201 gcatattacc tggtaataca gatataactc ccaacacaga aatggaagca acacgacatg
     1261 aaagagaaac aagaccaaga gctcccgaaa taatattctt ataattgcca ttaagtctgc
     1321 ttatgaatat attctgtgct ccaacaggta ttgttgaaat catcccatgg attatagaga
     1381 aaatagctac accgagaaca acattattat ctgttattaa cataaatagt aaaatacagg
     1441 cgattgaact aagaaatgaa cataatgtac aaacaagtat ataaagttta caccttacat
     1501 ctatctttgg cataagatag tttgctatat attgcattga aaatgcacca atatgacaca
     1561 tcagtaaagt tataagctct ctttttgata atgagccaat actttcccca gataacataa
     1621 ttggctgcca aaaatgataa attacctgta taccaagtgt aaacatacat gttatagata
     1681 aaaaatatgt cccattataa cttcctgtta tcaatccaat actctctttt gcttgtttaa
     1741 taatactatc tcgtgcttct ttttcacccc cactgccgtt agtttttaca cataaaaaaa
     1801 cgataaagac aacaaacatc aagaagaacg atactatata gccagattta taagaatcat
     1861 agaagtagac aactaatatt ccaacagcac cagttatcac actcccaaag gaagataccc
     1921 tttcgcataa atgagcacat aaggtaaatt tttcatttct accatccaga gcacttaaca
     1981 cccatccctc tatagcccca gatatacaac aaataccaat ggcataaaat atttcagaaa
     2041 aaaccaatgc cagcatatca ggagactgaa tacaaagagg gtaaaataaa atagtaaaaa
     2101 atacgccact aactacaacc tgtttcctgt aaaatctgtc tgcaatgaca gataaaggaa
     2161 aatcaagaat cagcactgtc acagaaaaaa cgatctgtaa aacagcaagt tgagatatag
     2221 tgacacctgt agatataaga aatgctgcat ggtagacacc aattaacata cgtatagcat
     2281 tataagctcc atagttcaca gataaaatat ttgcagtatt cacattctat ttccacacac
     2341 agagcaaaca ggcgaacggc ccatattttg ggaatgtatt tttatttcat ctgaccagat
     2401 gcctattctt ttattaagtg ataatggctc ggagtatttt ccaatgaact taattacgtc
     2461 tgccgcacat aatgcagcgg caacattatt cacaggtgca aatgttgctg gtttaaatct
     2521 gctattgatt agcttaatct tatgatcaat gttttccttt tctgaaccat atagatctgc
     2581 cacgactttt tggcactcat aacatcctgt tttaccagga acatataatg gaccaaagac
     2641 tgcaatatca ttaacatacc cagcatttat atagggctga tttgctctaa cgcaatattt
     2701 attaacccag ttgatcagat taaatggatg atctgcagaa acaacccata tatcagcttc
     2761 tggtacctta tgaagatcag tgtaatcgtt tatattcaaa gcgatttcag acaccgaaat
     2821 ttcagagttt ctttttaata actcgcgttt tataacttct gttttatttt taccgacatc
     2881 attctctgaa aataaaacct gccttgtcaa atttgtattt tctatttgat cattatcaat
     2941 tagtataatt tcgccaatac cagacgttgc gagtataaca gatacatgat ttcctatacc
     3001 cccacaacca agaattacta ccttagcatc ttttagttta tcttgcacaa gaacagggtt
     3061 agcaccataa ctttgataat gtaaaaagtt acgagagtaa cgattattct cagtagagtt
     3121 attatactca ccaggtataa taaagaaatt ttccttaagg aacctaaagc aattagagaa
     3181 atctttttca ggtatattga cagtttccaa cgctgcagta taactcgatg gggttatgaa
     3241 acaatatgcg gtttttataa tattttccca aagcgctaaa tcctcaacat attgctcctt
     3301 tccgcctcca ccaactaatc caccgctccc gtatcgagca attttgacat agcgacccaa
     3361 tatataatcc ataaataaac ctcgcagata aattttgtat gccaccctgt acagggtggc
     3421 atttaatgga catttatatt ttgccattag tttgcattac cagtacgcat tctacgcctc
     3481 ctattactgt gattaattca caagtgtttt tatcactata aaaaacaata ttcctcatga
     3541 aaatatacaa acatagattc atttcacaaa aaaagagcag cacaatcata ttatttgcgg
     3601 ttatacattt ttattctaaa atttattaat ttatatattt agacataaat aaccatacag
     3661 aatataatca tctacgttta aaccattttg taataaaaat ttgatacatc catcgttcat
     3721 tacattagaa accaataatc ctgattacca gtcacgttga gaagccactc aatgagcggt
     3781 ggtgcgctac gtgaaatctg aggtttttcg ggtcggattg gacacgagaa tttatgagaa
     3841 agaatcagga aatgccacga aaatggagat taattttcga tgaaaggcag ctcgcaatca
     3901 ccgcattcaa tattcactcc ggacttcccc cagacagcag caccacaccc cgacactgat
     3961 atttgacttt gttccttttt agcttgtcct caaaagccgc aacaaacaga tcgttatcat
     4021 tgctcccgtt ctacggtgac actgacagca ccggcttcga tatcaatccc ggttcagcat
     4081 tttgatgtgc ttgagcaagt agtttcccgc cattgatcga tgacggcggc catctctttt
     4141 tgttgttcaa cctggacagg gaagcgatca aaccagctca aagcaaattt accctgaaac
     4201 agttccagtg tgacgcgctg gaacgtaatc agacactcgg ggagttcacc gtcaaaaagg
     4261 cgctggttat agaaatcaaa cgcctattgt agctcgctgt agcgcgttct gtggctatcg
     4321 tcatcatcga caacccagca tttcgcgccg tcatattcat tgccactttc tgcaataaac
     4381 acgttctctt cagtatctac cgctatcact ctggggcgct catgctgagg ggcgcggaga
     4441 atatttttcc agcaatacac cttcccgtcc caaatcagaa tcacacccga atctgcgtgc
     4501 tccgggttgt gctgacgcca taccctggca atatcaagcc taggaagagc atcgagcgcg
     4561 taatattgct ggcaagaaag gtaagcaggg ggtatccctg ctttatgtac cagaaatcag
     4621 gcactgcccc atgagccatg tttcaggcat tgctggtaaa agacacttag aagctcttgc
     4681 tctgttggcg gttcttcgcc agaaattcca attctggctg ggataaatac gttttcgtct
     4741 ttccctgcca gtggccgcaa ctcatcagac tggcgcataa cgttatccaa cgcttttgcc
     4801 aactccgctc cattgctggc cggaatactg gtaagaacgg ccattccacc tttaatctcg
     4861 cgacgggagc cttttttcct ggcgatacac acaacaaata gctgtatttc aggttgcaac
     4921 catgcctgct gaacaaagcc gtcctgatag tgcacttcat gatgtgtgat tttgctgaga
     4981 tctgcacctg tctggaaata cattaatggt aatgtcagac tcaaaacatc ctcctgttta
     5041 tcaaaaaagt ctcctgcgta aaccagaagc ttattatatt actgttcgtc gccagcagag
     5101 ctggaagcat cttttttgat gataaactca tcaagagagc gaccgcctgc cagtgcttca
     5161 gctatcggtt ttggcgcacg tccacgacca gaccagtatt tcgtttcacc attttcttca
     5221 aattgatact tgggtggcgc ttttggtaac gtttttttac gtgattttgg tgcttcttcg
     5281 gacagaccaa gcagttcttc cggtgagaaa ccctctccgg cgattaactg aagcagttcc
     5341 tgacgtttcc gttcacgctc tgctcgttca accgcttcac gttcagcatc ttcacgacgt
     5401 tcttcaataa caacgttgag cttttcctgc atttcgagca actgctcaaa atcaatctca
     5461 cgggcaaaca cacgcaatga acgaatattc atcatagtcc ggctgataat gccgtattca
     5521 tcttctttag tcagttcgct cataattaat cctcttgttt agtggacgta cttccagacg
     5581 ccggaaggaa ccttatcata aagtttattc ataaccagtt ctgcgcggcg atggtctgcg
     5641 gcagaataaa atgcctctga ttctgataaa ggcagcttgt aacggttaat ctcaataact
     5701 ttttcaagag tatctcttga tgtacatttt cttaactgaa aaagccattc ctgctttgtt
     5761 ttcacttctt agcccttacc ggaaaaccca gcttccctgt tttcttatcc tcaaggacaa
     5821 gaactgtatc atacgttcca ccacttttct ttttaaatcc cttaatcaaa tcagttttcc
     5881 ctgatttaac cagtttttcg gcctgtgcct gggtgatttt cttaccaaaa aactcactcc
     5941 atattttaaa ttcacatccg atacagaaat aacctttcgg tctgataaca atatgtctac
     6001 cacaggaagg gcagggagag tccaggcgtt gaaactgccc tgctggcgca gcgggttcaa
     6061 tcttcatctt gcccaggtca acatcagaaa tcatgcctgt cagttcaccg tacagatcat
     6121 taataaactg ttcaaccgtc aggtcgccat tttcaatggc agcctgcttt tcagaccata
     6181 atgctgtcat atcaggatta accgctatac caggcagggc atcaataatc gcatatccgg
     6241 tatcagtagg aataagtttc cctttttcca gcgtgatata gtttctcttc ttcagcgttt
     6301 ccagaatggc agcgcgggta gctggcgtac caataccgcc atgttcatct tttttgtctt
     6361 tatccttatc cttcaacaat tttttaatcg ttggatcagt gacaaaatcc gcgacacgaa
     6421 caagtgcagc aagcaaggag gcttcggtga ataacggcgg cggtgttgtt ttcttctcat
     6481 taacaacaac ttcttttgtc gtcagtgttt ctcctgtgcg aattttacag agcagttcaa
     6541 aagcggaatc atcattatct tctgattcac caacgtctgt ggtttccgcg ccaagaaacg
     6601 cctcaaatcc gctgtcagtt gtttttctgg cacgggtaca gaacgactca tcaccacact
     6661 gaatggcaac cgatacttcc tggtatgctt tttcaggcat gaactgaaca agatagtgtt
     6721 gtgcgatcgc caggtaaaca ttgcgctcgt cggtgctgag tgcgttaaca tcaggcacac
     6781 tggcggtcgg gattatagca gtatgcgcag tcacctttgc actgttaaac gctttgcttt
     6841 tacgtgcaga atcaatatcc agcgactgag gaaagactga tttcagggca tcgataacct
     6901 gcggcgcttc gctgaattgt tcatcagaaa gatatgagca atcagagcgg ttataagtaa
     6961 tcgctttata tttttcacgt aattgttgcg taatatccag cgttttttgt gccgtcattt
     7021 tgaacttttt gttcatgtat tgctggagtc tgaccaggtt aaacggcaac ggcgcagccg
     7081 tttttttatc atcagttgct gctgcttcaa ctgtagccgg ttttcctgca agggatgctg
     7141 ccgttccgtc tgcccacgcc ttatcaagta atttacggtc ggtcagcgga gcaaattcac
     7201 ctggtttcca gttcgccctg agaacatcag caccacgctg aaaaactccg gtcatggtgt
     7261 agtaaaaact ggatttatgg ttctggttag cacgggtacg attcacaatc aggccaagaa
     7321 cgggtgtctg gacgcgcccg acagacagaa cgccctgata tcctctggct tttgcaggaa
     7381 tggtgtaagc acgcgtcatg gagaatccat agacggcatc ggcaactgaa cgcgccagcg
     7441 ccttaaggta aagccctttg aaatcacgat tatctttaag atttgccagt gcctttttca
     7501 ctgccggaag cgtgttgtcg tttatcagaa cgcgcttcac gggttttgtg tttcctgcat
     7561 attccaggac ttcatcaaca agtagctgtc cctcatcatc aggatcgcca gcgtgaacaa
     7621 tttcagtcac gtctccacgt ctgataagtt cgagaatcgt tttaacctgt tttgctgcac
     7681 tttcaacagg ctgatacttc acgggataaa gacgtaaagg aagcgtttca accttccagg
     7741 ctttgtattc aggattatag ttttccggcg gctgtgattc gataatatga ccaaaacagt
     7801 tagtcacaat ggcgttatca ctttcaaacc agccatcatg gcgggtaaag ttgccaccaa
     7861 gtgccttaac aatatcattt gctactgcgg gtttttcagc gataaaaagt ctcattaatt
     7921 acacctcaat tcaggttatg tactattcta ttttctctat gtgtatccct gatacccgtt
     7981 ggtgcgggta tcaggtttta actaacctct gacgcgacca aacttactca tgatcagtaa
     8041 gattgcagcc gggtctgccg ttgaacactg atttaaaaaa ttcttacgga gattaaatgt
     8101 tttactccag cgtatttttc cctttttctt ttcaattttg ttaaaaaaat ccttttcggc
     8161 actactgcac tcacttcccc caccttgccc gactgctttt ccatataagc aaagtaccga
     8221 ggcgcaaggg tcagatgcat acgcaggtgc tgtcagccag gacacagtaa aaattacgat
     8281 tagacttttg catatctttt tcatggtaac ctctgaacat ttattcttga cagataaatt
     8341 tcaacatagt cactattcaa ccatcttttt agtggctgat attcaataac acctgttgca
     8401 ccattttttc ttagccagta tttcgcagac cagtaactat caaaagaaga tgtccttaca
     8461 actatttttt cagagtgggc aacagcataa aagacagaat catcgtaaag acgattttct
     8521 ggtttaaaac caggtaacac cttactccat gaggaattta tattatctga tttaataaca
     8581 ccggatgttg gtttccagtt cattatttgt gtattcataa cttcaggccg tttttcccat
     8641 tcaacctgtg gcggttcagg tggagaggaa caggctgtga ggaaaagaat actgatcata
     8701 agtatctttt tcatagtaaa acctcagact ccagctctcc tacggagagc attttttctt
     8761 ttgacggata tttaagccct ttcacaccaa atattttttt cgtcttattt agttccatcg
     8821 tcaatgatgc cagtttagga ctgaccttca ttaacctgtc cataaaatac ggatcaaggt
     8881 aataaagtgc cttttctgct ttaacagggt tctccccctt caggatgata aactcttctt
     8941 taaagtccag cgttcccagc tcctgtggaa gcaccagtgc tcttcgggct tcactttctg
     9001 attcgccctg tgatgttgac cgtccacggc tcttgcttgt gctctttgat gtagtggtaa
     9061 tatatccaag tttttctgat attttcgcgg catcatcctc ttcactgaca gcatagataa
     9121 tacgacaggg atgagcactc atcagcgttt tggctccctc aataccatag atttcattta
     9181 gctgactgat attctgataa attgtcagca gtttaagttt aaaacctgca atataccctg
     9241 accccttttt aataattggc atataaccaa tcgaagggaa ctcatcaaga aacatcaggc
     9301 agtcatgttt cagggttgga tcaaaatcag gattttcacg caatgtcact tcaacaacga
     9361 agttaaaaaa caggttcaga aaatcgtaag ccagagatat atcttctgca ttaacaccga
     9421 cataaacagt gatatcttcc cgtcgcaact gacggagatc gaaatcatta ccatcagtac
     9481 atttacgaac ggttgggaga taaaacaggc tcattttctt acggaaagaa ccatcaatgc
     9541 ttgaacgctg ttcatcttcc gtttcgtgat attccctgat tttggtcaga gcatcgcgca
     9601 aatgatacag cgcgttttca tcaagcccgt ttgtttcctc cagttcttcc cgcttactga
     9661 gtatcagttc ccggtcaata ttgctgtaca agtcgacgac agaaccgatt gagaaaacgg
     9721 gtttaagccc gaactcatta agccaggacg gctcataatt aataaagaaa tgaagcaact
     9781 tagccagtcc cgtccagtat tgaccagcaa ggttattaaa gtgcgcttct gcccctgtca
     9841 tgccgtaaga cgggaacaga atttcaatca gtttaagcag atccttagca ccactctccg
     9901 cttttaaatc aatatagaaa agggggttaa attgatgtgt cttactgttg aatgggtcga
     9961 gaagataaac tttattcccc agcagtattt cacgcacctt actggtgatt ttccacaatt
    10021 cctgttttgg atctaacgca ataagagagt gttttctgac cagaagatta gggataccaa
    10081 tggcggctcc tttaccggcg cgggttcctg caccaagaga tacaaaatcc ggggcagtat
    10141 accacagata ttttccttta tacgcgccga ccagaatatc cgtatcattt tctgtctccc
    10201 acttaagcag ttttgatttt tttaaatcat tgtcactggc aaacttcgca tcaccataaa
    10261 gagcaacatc cattttattc agttgccaga taataaaaac aggcacaatg agagacgaaa
    10321 ccatacctga caaaagagag gggatagcgg ttaacctgat atctgtacgt atattactct
    10381 ctgttattat tttccagagc aacatggaat caaaattttt ccatatatac agtggtgttt
    10441 ttccgttaaa gaaataaaca gcaacagaac cagcataata ggtcacgaga cacataacca
    10501 gaccgataaa aaaccactgg cctttatcgg gaagttttaa agacataatc actccttcag
    10561 ttttctgaaa taatcatcaa aatgaagttg tctgtagtaa atgccggaag cgaaccgaaa
    10621 atcttcatca tcaaggtatt taatactcat gataatatca atattactca gtacacgtct
    10681 taaaataaca ttgaatggta gattctgaca ttcaggattc atataacatc gctggacaat
    10741 cccaagcacg gcatattcag gactactttc gtgaacggtg gtaatgtttc ctgcatggcc
    10801 tgaactcgat gctttcagaa aatcccatgc ctcagccccc ctgatttctg tcatcagaat
    10861 cctgtccgga ttcatacgaa aacaggaacg cagaagactc gctgaggtaa taaccttact
    10921 ctcaccctct gccggatagt aaagttttac atggttttta tggaatctga attttgcctc
    10981 atcagtatct tcaatagaaa tacaccgcag atgatgcggt atatattcca gacaagcatt
    11041 tgcaaaggta gttttacctg aacccgtccc tccacagaaa actatcgttt tcccctgacg
    11101 cagtgattca ggtataaccc gttcaaaata tccggaagtg attaaagcag aaatattatc
    11161 ttccataacc gagtcaccac ttaaaccact gacgcgtgaa taaaatccct gttttataaa
    11221 tttgtcatga ctgataaaaa tacctgacgg cttacggatt gttatagaaa cagtatcttt
    11281 ttcagttgcc ggtgggatca caacctgaac acgttctcca cccggaagcg tggcagaacg
    11341 caggggatat tcaggagtca cagaaccgcc gtcatgaaaa tcagcaagtg tggatgcaaa
    11401 agaaagacaa tcactgtaac tcatcttttg ttcataccat tgccactttc ccctgacctt
    11461 tataaatatt tctcctggtc ggttaacagc gatttcagtg acaccatcaa tctcattcag
    11521 ccagtgataa aaatagtcgt taaccacatc ataaatcaga tgtctgtttt cgttattcac
    11581 attaaccccc tttcattttc agtttataaa tgcctgaaaa atccagatcc tgaccgacaa
    11641 tcagagtaat aatttcgccc tgatttttat aaagcgttgg cggaatattc acactattag
    11701 aaaatgcttc gcgtgctata tcagaaaaag cctggcgact gtttgccgta tagtcggtct
    11761 ggctgtccct gttgttctgt gcaataccac tggcggcctg acttaaatcc ggtatcatcc
    11821 cgaccatcat cgcccccaga aaacgctcac caaaatgcgt gtcaatccat cctgaagccc
    11881 cggcttcgcc taacgctcca gccgcctgtg agtcaatcag gggaatatca atgaacggcc
    11941 tgctgcgggt gcgtaacttg taagccataa caaacactcg tccctgacca tgccttaacg
    12001 ttcccgcctt atacatcagt tttgcggcgg ttcctctttc gataagtttt acattaccgc
    12061 tggcgctgta tatatcgctg ttaaccgtac attccagttt ccccgccagg tcagaaacaa
    12121 aacgcctgtc cagtgaacag ggaattgatg tcccttccgg gataaacaaa tttgggtcat
    12181 atggaagttt cgttattttc gccagtggcg cagattctgt agtctgtgcg gttgcttttg
    12241 cttcatcctt tttatcgctt tctagctcac tggccgcagt atgtgaaact gacgttcccg
    12301 ctgaactgct gctgtttcct gcctggctgc catcaagaga aacgtcaagt gcacggctga
    12361 agctctgctg tttattttcc ggcggttcag tcttttcaga agaaatgact ttttcttcct
    12421 ctggtttctc tgtttttttc tgtgcggtat taaaaggatc gatatcttcg ctcagtccgg
    12481 tctgacgttt agccgctccg gtcgcaagcg gctgacttgc gggtttctca tcccctgacg
    12541 acacagatcg gataatggac gggatataat aaacagaaac accggcagca agcagaagaa
    12601 aaccaacgac gagaataatc atccctttac gtgacttttt aagtttttca ataccaagct
    12661 gcaatgctgg cttgccaggc tcttcttccg gagtcttccc ggcctgttcc agttctttct
    12721 gtctgcgttc ccgtagctgc tgttcaattt cggttgcagt cgggatttta ttttcctgtt
    12781 cagtcactgg atcacctctt tcttaacatc cggggatacc gtatctccgg ctggtaaacg
    12841 tacttttccg aagccctggt tctcaatccc caccacctgc tcaccaagac gtaaaacaaa
    12901 acgcttatca accggtacgc caacagccgt aaaactcccg ctctgtttaa tcacaggatt
    12961 ggtaagagtc tcctgcatac cgttcatcac aaagacgctg ggaattttct ttaacggact
    13021 gaagccgaac caggtataac gaccatcgtc atatgcataa tcagggctga tatcctggct
    13081 gccttcagca acccgcttcc agtactgcca gttacggggc gatttcgcat tttccaggga
    13141 acggttgatt gcctgttctt ccaggcgtct ggcaagagcc tctgttcgtt tcttctctat
    13201 ttcggcctgt tccttccggc gttcctgcgg atactggtaa ttcaccacaa acgcaatttt
    13261 ctccggctgt cggaacgttc tggcgttcag ctccatgctg taattacgtt tcgtggtgcg
    13321 aacaaacaga ttcgttctcc agcgttcaag ttcattttcc gggtcaagag ca
//
