LOCUS       NZ_CP074527.1          15271 bp    DNA              UNK 01-JAN-1980
DEFINITION  NZ_CP074527.1 Klebsiella pneumoniae strain S12_CRE12 plasmid
            pCRE12_4, complete sequence.
ACCESSION   NZ_CP074527
VERSION     NZ_CP074527.1
KEYWORDS    .
SOURCE      .
  ORGANISM  .
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-06-07 15:07:33
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             44..463
                     /locus_tag="ctg1_1"
                     /transl_table=11
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
     CDS             769..1032
                     /locus_tag="ctg1_2"
                     /transl_table=11
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
     CDS             1022..1321
                     /locus_tag="ctg1_3"
                     /transl_table=11
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
     CDS             complement(1383..1760)
                     /locus_tag="ctg1_4"
                     /transl_table=11
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
     CDS             1829..2008
                     /locus_tag="ctg1_5"
                     /transl_table=11
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
     CDS             complement(2036..2566)
                     /locus_tag="ctg1_6"
                     /transl_table=11
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
     protocluster    2250..13935
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[7249:8935]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      7250..8935
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    2250..13935
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          2250..13935
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             complement(2573..3304)
                     /locus_tag="ctg1_7"
                     /transl_table=11
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
     CDS             complement(3304..5268)
                     /locus_tag="ctg1_8"
                     /transl_table=11
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
     CDS             complement(5980..6108)
                     /locus_tag="ctg1_9"
                     /transl_table=11
                     /translation="MEKRHLRGLAVLPHMLVPCLFTESVGNFACVRSARRSLTAGA"
     CDS             complement(6983..7240)
                     /locus_tag="ctg1_10"
                     /transl_table=11
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
     CDS             complement(7250..8935)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Cloacin"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_11"
                     /sec_met_domain="Cloacin (E-value: 2.1e-113, bitscore:
                     367.1, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
     CDS             complement(9671..10375)
                     /locus_tag="ctg1_12"
                     /transl_table=11
                     /translation="MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDHS
                     TIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDF
                     YLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHR
                     QIKYRNNVIECDHGKLKRIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPL
                     GEMRLVSRVFEM"
     CDS             complement(10387..10644)
                     /locus_tag="ctg1_13"
                     /transl_table=11
                     /translation="MIAEVSTQLSEVVGVIERHLEPTLLAVHLYGSAVDGGLKPHSDID
                     LLVTVTVRLDETTRRALINDLLETALLQIVGGDKLIIPFC"
     CDS             complement(10726..11331)
                     /gene_functions="resistance (resist) AAC6-Ib (Score: 433;
                     E-value: 5.6e-133)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1203:putative siderophore biosynthesis protein (Score:
                     62.9; E-value: 6.5e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_14"
                     /transl_table=11
                     /translation="MSIQHFQTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRS
                     HIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGW
                     WEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAI
                     RCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSVA"
     CDS             complement(11514..12071)
                     /locus_tag="ctg1_15"
                     /transl_table=11
                     /translation="MRIFGYARVSTSQQSLDIQIRALKDAGVKANRIFTDKASGSSTDR
                     EGLDLLRMKVEEGDVILVKKLDRLGRDTADMIQLIKEFDAQGVAVRFIDDGISTDGDMG
                     QMVVTILSAVAQAERRRILERTNEGRQEAKLKGIKFGRRRTVDRNVVLTLHQKGTGATE
                     IAHQLSIARSTVYKILEDERAS"
     CDS             12233..15238
                     /locus_tag="ctg1_16"
                     /transl_table=11
                     /translation="MPVDFLTTEQVESYGRFTGEPDELQLARYFHLDEADKEFIGKSRG
                     DHNRLGIALQIGCVRFLGTFLTDMNHIPSGVRHFTARQLGIRDITVLAEYGQRENTRRE
                     HAALIRQHYQYREFAWPWTFRLTRLLYTRSWISNERPGLLFDLATGWLMQHRIILPGAT
                     TLTRLISEVREKATLRLWNKLALIPSAEQRSQLEMLLGPTDCSRLSLLESLKKGPVTIS
                     GPAFNEAIERWKTLNDFGLHAENLSTLPAVRLKNLARYAGMTSVFNIARMSPQKRMAVL
                     VAFVLAWETLALDDALDVLDAMLAVIIRDARKIGQKKRLRSLKDLDKSALALASACSYL
                     LKEETPDESIRAEVFSYIPRQKLAEIITLVREIARPSDDNFHDEMVEQYGRVRRFLPHL
                     LNTVKFSSAPAGVTTLNACDYLSREFSSRRQFFDDAPTEIISQSWKRLVINKEKHITRR
                     GYTLCFLSKLQDSLRRRDVYVTGSNRWGDPRARLLQGADWQANRIKVYRSLGHPTDPQE
                     AIKSLGHQLDSRYRQVAARLGENEAVELDVSGPKPRLTISPLASLDEPDSLKRLSKMIS
                     DLLPPVDLTELLLEINAHTGFADEFFHASEASARVDDLPVSISAVLMAEACNIGLEPLI
                     RSNVPALTRHRLNWTKANYLRAETITSANARLVDFQATLPLAQIWGGGEVASADGMRFV
                     TPVRTINAGPNRKYFGNNRGITWYNFVSDQYSGFHGIVIPGTLRDSIFVLEGLLEQETG
                     LNPTEIMTDTAGASDLVFGLFWLLGYQFSPRLADAGASVFWRMDHDADYGVLNDIARGQ
                     SDPRKIVLQWDEMIRTAGSLKLGKVQASVLVRSLLKSERPSGLTQAIIEVGRINKTLYL
                     LNYIDDEDYRRRILTQLNRGESRHAVARAICHGQKGEIRKRYTDGQEDQLGALGLVTNA
                     VVLWNTIYMQAALDHLRAQGETLNDEDIARLSPLCHGHINMLGHYSFTLAELVTKGHLR
                     PLKEASEAENVA"
ORIGIN
        1 tataactcaa tgagaaaaaa gaattaaagg taaggagacg ctcatgagac gttccggcag
       61 caaactgtgt cttatcgcca tgataacagc gacagcaact ctcactgcct gtgctccaaa
      121 gggcagcgtg gaacagcata cccggcatta cgtatatgct tcagatgacg gttttgatcc
      181 caatttttcc acccagaaag ctgacacaac acgaatgatg gtgccttttt tccggcagtt
      241 ctgggatatg ggcgcaaagg ataaagcgac cggaaaatca cggagtgatg tgcagcaacg
      301 cattcagcag tttcacagtc aggaattttt aaactcactc caaggcacaa cacaatttgc
      361 gggtaccgat taccgcagca aagacctcac accgaaaaaa tcaaggctac tggctgacac
      421 catttcagct gtttatctcg atggctatga aggcagacag taagtggatt taccataacg
      481 cgtcattacg cgcaccgctc agacgggctc agggcgtttc cggcggctac gggataaaac
      541 aggcaacaac ccccccggaa aactgccgga aacgcgcccg ataaatttta tcctaatgca
      601 tgcctatgca cgcaactgca tggcatatgt tttgacgtaa aatggatgcc gtaagccctt
      661 ttttaccgac tttctgcttc atcagcctga ctgacacgac catattcttt cagaccgccc
      721 cctgctaaac ttccttcata ttgccgcatt aacccgggag gctccgcaat gagcaacact
      781 acacactacg aaaacgccaa ctttcttcgg gaactggctg aaagcctgcc ccgcatactg
      841 ccggaaggtg gcccggacaa agctgcgctg ttgcagcgac tggctaacga agaactggcc
      901 caggcagagt atgaagatca ggttcgcgcc aaagtgaccg ccgcccgtgc tgacacgcgt
      961 ccgggtatga ccacggaaca actccgccag cgcctgcatg gccgttatca ggaactgcgc
     1021 gatgccgtat gacgtggaat ggaagcaggg agccatcgag gatgtaacga cgctgtttga
     1081 ctatatcgcg gaaaattcat ccctgtggga tgcgcagaac gttaccgacc gggttctcgc
     1141 tgcggcggac aaactggccg acttcccgcg actctatgaa gtggactcac gctatggcga
     1201 ggacgttcgc cggatcagtc tgatgggaca gcatgtcctc tatgatgttg atgaccagac
     1261 cagaaaagtc cgggttctgg ccgtggtcgg ccagcgccag aatccccata ttgttctcta
     1321 ataaccggtg acggggacgc aattcattgc gtggccgtcg ccggttggac aagcacagcg
     1381 cgtcagcgtt ttccccacgg ccaccaccgg cgcggtgttc cggccggggt ctctgctgtc
     1441 tccggtttgt gttccagcag tctcatggac tgcatttcct gccgtagccc ggccacctcc
     1501 tccctgagtg cttttatctc cgcgatcaac gcgtcggagg ccattttttc agtctcaccc
     1561 gacagtctca actcgtcccg ctcgtgagtc tcatcctgtc ttaactcacc gtacacccgg
     1621 ataagctcgc tggtatccac cacccggccg ccatcagctt ccgtacggta tgatacgcgg
     1681 cctttcgcca tatcccgata cagggaactt cgggctttac ccgtcagttc cgtcgcctgt
     1741 ctcaccgtca cccacgccat tgtctcaccc cgctattttt gagacagtat acctgacagg
     1801 cgcacaccat gcccggaagg aaagaatcat gacaaaacag gaaaaaacag ccctcaatat
     1861 ggctaaattt attaaggagc agtcgctgct attgctcgat aaactgaatg agctggatat
     1921 ggataccccg gccgacatgt gcgagcggct acacgaggat gcggaaacac tctggcaggt
     1981 gatgcgggat aagctcgggg aggaataaca gcaccggcat ggccggtgct ggcatttatt
     2041 ttttgccgaa cggccaccac cggcgggcag gtttgtcctc cggcagttca ggtaccggca
     2101 cgttaaaata gcggctgtta tattcccgca tcagctccgc tttcagcttc tcgttcaccg
     2161 cgctttcccc gtgccgctca ctcaccacgt caatcatcgc gttaatctgc tccggtgagc
     2221 acttcccggc atcaaccacc tgcacaccgt tctcgatggc gaaccgctcc accttgcgat
     2281 agaggtaatc acacagcttc attcctgtgg gtttgttccg ttcccattgc ggatttttac
     2341 cagtgaaaaa gtacgtggct ttttcgtcgc tgttgagccg ctcgtcatac atcccgatgg
     2401 atttcatcat cgccagatgc tgggcccggt cgacaaaaca gaaaacatac gccccggtct
     2461 gccaggcgag caccaccata tcttccagat gctcgctggt cggcatgatg cagcgctcgc
     2521 cgttccggtc ctccgcgtct tcaataaata ccatgtacag cgccataatc cctcactccg
     2581 ttgtcataaa tttaaagcac gcaaacaacc gttcacgatc cagctctgcc gttttgcggg
     2641 cctcgccggt ctgtgggttc acgatttcat ccaccgacag gattgcccgc tgcaccctga
     2701 cctgcgtcgc ccggtccggg cagatgtacc agatttcatc gatgccgtta gctttgcggt
     2761 tgaacagata cccggacacc acttcctgat accggcgacg gctcttgacg gtgcgctcca
     2821 cctcaaacgc caccgtttta ccgtccagct ccgccagggc gtccggcact ttcatgcctt
     2881 taagactcag acggtgcaga atgcgccagc cggtggcccc tctggcttcc atatcaaggc
     2941 gcagggattg cacggccagc cggtgcggca gatgtgctgc cgacaccctt gacggctgaa
     3001 acggaataac atccgccagc ggttcgtcct cgtcgaacga gaacgccacg ccatgcggcg
     3061 tcagccccca cacgctgacc tgacggccgt ccaccggata tttggtccgg accagcagcc
     3121 ctttcgccac caggctgtcg aggaagcggt agaccggctg caccgccgca atccccagcc
     3181 gccgcgcaac cagctccgcc gtggaacaca gctcttcccg caaccagcgc agggtcagcc
     3241 gggttttctc cgcgttccgc gcctgtcgtt tcgcgtggct gacgttgtac agctccagcg
     3301 ccatcagtaa atccccgcaa aatcatcatc cgctttcggc ccgccgccgt cggccggggg
     3361 ccggaactcc gccaggggat cggttttcgc cagcaccggg aaacgctgca acgggatttc
     3421 ccggcgctca acccgcagcg gactgctgaa cgccatccgg gccacaccca gcccggtcat
     3481 gaccgcgaac ccgtccggca ggtgttgcag ggtgttcacg tcaaacagcg gccgcgcctc
     3541 cttctggatg aagctgtccc cgctgatatg ctccacgttc cccgcctccc ggctggcacg
     3601 gcggcgctcc acgtccaccc tgatttcccc ggtctgcccc gccgcccact gcgcggactc
     3661 caggctggcc gcccggtaaa accagcggat cggcgtgtta tccagtaccg tggttttcac
     3721 aaattcagcg ggcagatcct gcccgcactg cccgaaatcg cccagcgact ggtgcgcgag
     3781 caacagattg cagtcccggc tgcgcagcgt ccccagtgcg ttcagtacat acttcgacag
     3841 cagatattta atttcatcga gcatcacgct gacgtgtggc cactcccgga actcgtcccg
     3901 cgcaatgatg atttgcgcgc agcgggcaaa cagcattttt tgcacacgga tcaccgcctc
     3961 gtcgtccatc gagccgataa cgtacaggca gccgccgccg ttgataatcc ccgccacatc
     4021 gatgccactg tccgtctgca ggacgctcag gtcagcgacg ttttccagcc tagtgatcaa
     4081 ccccttcacg tcctttttca gggcctccgg cagcgcgtac gccgccgcca gcacctgctg
     4141 aatgtttgcc ccctgcggaa actgctccgc aatcagcttc gccgctttct gctcgctgat
     4201 gcggtagtgg tccgccacgt cgccggtctc gcccaggtta agcccggcaa tcagcaggtt
     4261 tttcagcgcg tactggtcga gatcgcggaa cagattcagc tgcgccggtt tccccggccg
     4321 cagatccagc agggtgaagt ccggacagtg cgcccggaag acgtgcggcg cccatgcgtc
     4381 ccctttgggg tcgaagtaca ccaccgcgtc cccgaaatcg cgtacgcagc gaatgagcgc
     4441 gttggtggcc atcacgctct tgccgctccc gggcaggccg aggatctgaa tgttggtctt
     4501 gcgccaggta tcacgcggaa ccagcaccgg cttgccctgc tcatccttac ccagaaacac
     4561 cgcctgctcc tgccgggcct gctccgagga aaaatcggcc agcgcattaa ccggtaccgg
     4621 ctccccgaaa tgcaggtggc gcacgtcggt catctctcct gtccgctggc tgctgcgccg
     4681 gctctcctga ttcagtttcg cgttcaccgc ctcgtcagca gccgcaaaat gaccgtcaag
     4741 cagcaggaac gccagcagcc gcgccaacac aatcccgaca gccagcccgc ccgcgcacca
     4801 ggcaatcccg aacaggttag ccggctgcag caggtaataa tctgcgtttg cgtagaggtc
     4861 cggacgcagg acggtttctc cccagctctc gataaacacg gcgacaacca gcccccccag
     4921 aagggccaga ccggccgcgc cggtcagcca gtacgcgtag ttccagacat gtcgacgtgc
     4981 cctgaccatc cgcccgggcg aatccagcga ggccagcacc gaaaatggcg ctggccgttt
     5041 attatcgcgc ttatagcgat cggcatactc ccgtcgctcc ttatgactca gccccacaaa
     5101 acgcatccgt ccggcccaaa gttcagccag accgaaaaac aggccgataa ctaggaaagc
     5161 cccggccaga ccgtaatact cctggtacag ccagctgacc cacggataaa tctgccgggc
     5221 cagctccgga atgtgccact tccaggcaag cgaatccgta ttaaacatgt tctctctcct
     5281 tcagacgatg gtttgccggc gtgatgtgca gcccccgctg cacaagccgc ggacatgccc
     5341 caaggcatgg cggcggcggt cacgtccgtg gtgattgcgt tcagctttca ccacggaggc
     5401 cagcctcttt ccgccccatg cggaaaaggc gcagccccgg aggaacaacg agcacgcccc
     5461 agcgtgtgag aggaaaaggc ggcaccccag tgcggtcttt tccggtgttc cggcccccgt
     5521 cagagttcgc catagcgagc ggctgaccac ccgcaaaatc aggagcagct ttgctgcttc
     5581 gccaggtgcg tccagcaccg tggatttttg tgggtggtca ggcgtgagcc tgacgggggc
     5641 cgggtgaatt tctggcgtgg ccggcgtcca gccggacgga gccagaaaga gggggagaga
     5701 ccgtgcgtcg gtggcgtcca gccagcgtaa gcaggggata tccccctgag gtcagccacg
     5761 ccctcgcggg gatgacctgt atttctccgt aaggagaaaa aagcaacaga gataggttaa
     5821 cgtaaaatgt tcagcgaaaa accgatatga ttcacctatc ctggtaattt attatcaggg
     5881 aatataaaga cttaatcagg ggacaatatg ccacatcagc gcgtccggtg tccgtcttgt
     5941 aggtgccggg gaaattgcgc ctcctcgctc actcggtcgc tacgctccgg ccgtgagact
     6001 gcggcgggcg ctgcggacac atgcaaagtt acccacagat tccgtgaata agcaggggac
     6061 taacatgtga ggcaaaacgg caaggccacg caggtggcgt ttttccatag gctccgccct
     6121 cctgactgag ttcacataaa cagacgcttt ttcggtgcat ctgtgggagc cggtggctca
     6181 accatgaatc agtcaggagt ggcgaaaccc gacaggactt aaagatcatc accgtttccg
     6241 atgaatcgct ccctcttgcg ctctcctgtt ccaaccctgc cgtttcccgg atacctgttc
     6301 cgcctttctc ccttgcggga agtgtggcgc tttctcatag ctcacactct ggtatctcgg
     6361 ctcggtgtag gtcgttcgct ccaagctggg ctgtaagcaa gaaccccccg ttcagcccga
     6421 ctgctgcgcc ttatccggta actgttcact tgagtccaac ccggaaaagc acgcaaaacg
     6481 ccactggcag cagccattgg taactgggag ttcgcagagg atttgtttag ctaaacacgc
     6541 ggttgctctt gaagtgtgcg ccaaagtccg gctacactgg aaggacagat ttggttgctg
     6601 tgctctgcga aagccagtta ccacggttaa gcagttcccc aactgactta accttcgatc
     6661 aaaccacctc cccaggtggt tttttcgttt acagggcaaa agattacgcg cagaaaaaaa
     6721 ggatctcaag aagatccttt gatcttttct actgaaccgc gatccccgtc agttcagagg
     6781 aggacgatgg tgccaccgtt ccaccctgaa catcccggat atagtttgcc tgacatgcga
     6841 ccagaagaaa gcctgaaaaa atcaatataa aaagaaaaac aacctttacc tttttcatat
     6901 accttccctg tatttaaaaa ccccggtatt catccctgaa caccggaagt ctgtatttca
     6961 aatcatcctt gataactttt gcttaccagt taccatcccg gtaaacaaag gatacaaagt
     7021 aatcaaattt actaatatcg attacatttt taaagtgtgg ctgtaatatc gaaacccatg
     7081 atttttcaac atcaaaccaa ccattattaa tattatcctt taaaggcatc cccagacttt
     7141 caatgacaga accatcatca ccgaagtctt ttgagtattc accaccttta aactcttcgg
     7201 ttttcttatc aaaccaatga atatgtaatt taagccccat atttacctct taaagatatt
     7261 ttttaatgtt tcgttttgga tccggccctt taacctgctt acccgttttt ggatcgaatg
     7321 ccccgaggtg ttcgccatca ctggcgcggt acccttcaag ctcaccgtgc tgggaatccc
     7381 attcataaat tttacgcttt ttatcaccat accatcgggc ccgcttacca ccaccacctt
     7441 gtttaggggt tttaggttta ccctctttca actctcccaa ccccttaata tcttcagtct
     7501 tgggatcagg aaaataatca tggccgtaat ctttagttcc cttacgaggt tttttctttt
     7561 cctcatttaa tttattttct gcatccttcg cttttttctc cttttgtttc cggctctcca
     7621 tcgccccgga aagcgcagcc ttatccctgg ataaggattc attcatttcg tttaaagatg
     7681 tctgggcagc ttttaatttc tcattctgat tctgaatatc cttatcaaga tagcgaacct
     7741 gatcctgcca cccggagcca tattcatgag gcgggttata agtcacaaaa tcatctttat
     7801 ttgcctctgc ctcttttacc tttttatcgg cttcctgaac agcagccctt gcaccgggga
     7861 tcgccttctc tgtcgatgca atgcgactgt ttaaggtcgc aatattttta tcttcagcat
     7921 ccagctcagc tttcgcttta tcatactctc ttttcagccc ctcttccggg tgagcagcgt
     7981 cccatgcctg ctggcgacgc ttttcttcct ccagacgctg ttttacctgt gccggagtaa
     8041 gaacatccgt caccgacaca tagaccggtt tctgtccgct ctctttcggg aaacgaataa
     8101 cggcttcacg ggagttacca ccggccgtaa aaccagccgg acgtgaatca cctttttcag
     8161 caataatgcc ttttggcggg gctttcgcgg ccggaacacc tttaggtacg ctcacctgca
     8221 gagacgggag acccggaatc gacacactga atacccccgg acgttttgtc ggtttcgcat
     8281 ccaccacagg aacactcatt ggccggccgg tgacaaccgc aatatgctgc cgctcgtcct
     8341 tcacaatatc cgccacacgt ttagtgacgc tgaccgtcgc ctggtccagc ggcagggagc
     8401 tgaccggcgt ctccgttacc gtgtctgccg gcaatgacgt cacgattttt gacatcattt
     8461 tcggatcatc ttttgctatc tcagaaggca gcactccgta aatcgcaatc ccccacagac
     8521 caaacttaaa cggacctttc agggcagcca gcacatcagc aacagcggcc gacaacgcat
     8581 cgccggaaac ggataaagcc agtccttcag cccccggagt ggccaaggca ggcagaccga
     8641 aggccatcgc ggtggccgaa gactgtccgc caccagagct cccgctatga ttgccgctgt
     8701 taccgccatt accaccgggt ttactcccgc cgttaccaaa ctcccccggg ttatagttat
     8761 gaatatcccc gttaggtgta tgcgtcgtac cccagcccgg cccgctgttt ggatccgtac
     8821 caccacctga tgaagggcca cctttacctg atgtaccgtt cacattccca ctggcctgac
     8881 caccattgtg tcccagacct gaattacccg gacctcgtcc gtctccgcca ctcatatact
     8941 tttcctcttt gacttttaaa acaataaact aaaataaaat actgtacata taaccactgg
     9001 ttttatatac agtataaaaa ttacgctgcc ttgtttttca tgtcaagtct gtaaatttgc
     9061 gtttttgtga aaatgatcaa aaaaacagcc actcacacca tgcgcaatcc cctccagatg
     9121 caacaaaaac cagcacaaac ggcgccgttc tccggcctca gtatgtttta ctgaaatcat
     9181 tatatgagat accagaaagc cccctccggg acaggaaaag aaacgggggt ctggttcggg
     9241 ttgttcggtc actgaacacg gtcagaaact gatgataaga tagcctgcgg atatataagg
     9301 ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg agattatcaa
     9361 aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta
     9421 tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag
     9481 cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag ataactacga
     9541 tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac ccacgctcac
     9601 cggctccaga tttatcaggg cactgttgca aagttagcga tgaggcagcc ttttgtctta
     9661 ttcaaaggcc ttacatttca aaaactctgc ttaccaggcg catttcgccc aggggatcac
     9721 cataataaaa tgctgaggcc tggcctttgc gtagtgcacg catcacctca atacctttga
     9781 tggtggcgta agccgtcttc atggatttaa atcccagcgt ggcgccgatt atccgtttca
     9841 gtttgccatg atcgcattca atcacgttgt tccggtactt aatctgtcgg tgttcaacgt
     9901 cagacgggca ccggccttcg cgtttgagca gagcaagcgc gcgaccatag gcgggcgctt
     9961 tatccgtgtt gatgaatcgc gggatctgcc acttcttcac gttgttgagg attttaccca
    10021 gaaaccggta tgcagctttg ctgttacgac gggaggagag ataaaaatcg acagtgcggc
    10081 cccggctgtc gacggcccgg tacagatacg cccagcggcc attgaccttc acgtaggttt
    10141 catccatgtg ccacgggcaa agatcggaag ggttacgcca gtaccagcgc agccgttttt
    10201 ccatttcagg cgcataacgc tgaacccagc ggtaaatcgt ggagtgatcg acattcactc
    10261 cgcgttcagc cagcatctcc tgcagctcac ggtaactgat gccgtatttg cagtaccagc
    10321 gtacggccca cagaatgatg tcacgctgaa aatgccggcc tttgaatggg ttcatgtgca
    10381 gctccatcag caaaagggga tgataagttt atcaccaccg actatttgca acagtgccgt
    10441 ttccaaaagg tcgttgatca aagctcgccg cgttgtttca tcaagcctta cggtcaccgt
    10501 aaccagcaaa tcaatatcac tgtgtggctt caggccgcca tccactgcgg agccgtacaa
    10561 atgtacggcc agcaacgtcg gttcgagatg gcgctcgatg acgccaacta cctctgatag
    10621 ttgagtcgat acttcggcga tcaccgcttc cctcatgatg tttaacgttt gacatgaggg
    10681 gcggccaagg gcgccagccc ttggacgtcc ccctcgatgg aagggttagg caacactgcg
    10741 tgttcgctcg aatgcctggc gtgtttgaac catgtacacg gctggaccat ctggggtggt
    10801 tacggtacct tgcctctcaa accccgcttt ctcgtagcat cggatcgctc gcaagttgct
    10861 cggcgacggg tccgtttgga tcttggtgac ctcgggatca ttgaacagca actcaaccag
    10921 agctcgaacc agcttggttc ccaagccttt gcccagttgt gatgcattcg ccagtaactg
    10981 gtctattccg cgtactcctg gatcggtttc ttcttcccac catccgtccc cgcttccaag
    11041 agcaacgtac gactgggcat acccaatcgg ctctccattc agcattgcaa tgtatggagt
    11101 gacggactct tgcgctaaaa cgcttggcaa gtactgttcc tgtacgtcag caagtgtcgg
    11161 gcgtgcttct tctccgcccc accactcgac gatatgagat cgatttagcc actcatagag
    11221 catcgcaagg tcatgctcag tcatgaggcg cagtgtgacg gaatcgttgc tgttggtcac
    11281 gatgctgtac tttgtgatgc ctaactttgt ttggaaatgt tgaatactca tactcttcct
    11341 ttttcaatat tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga
    11401 atgtatttag aaaaataaac aaataggggt tccgcgcact tttccccgaa aagtgccacc
    11461 tgacgtctaa gaaaccatta ttatcatgac attaacctat aaaaataggc gtatcacgag
    11521 gccctttcgt cttcaagaat tttataaacc gtggagcggg caatactgag ctgatgagca
    11581 atttccgttg caccagtgcc cttctgatga agcgtcagca cgacgttcct gtccacggta
    11641 cgcctgcggc caaatttgat tcctttcagc tttgcttcct gtcggccctc attcgtgcgc
    11701 tctaggatcc tccggcgttc agcctgtgcc acagccgaca ggatggtgac caccatttgc
    11761 cccatatcac cgtcggtact gatcccgtcg tcaataaacc gaaccgctac accctgagca
    11821 tcaaactctt ttatcagttg gatcatgtcg gcggtgtcgc ggccaagacg gtcgagcttc
    11881 ttcaccagaa tgacatcacc ttcctccacc ttcatcctca gcaaatccag cccttcccga
    11941 tctgttgaac tgccggatgc cttgtcggta aagatgcggt tagcttttac ccctgcatct
    12001 ttgagcgctc tgatctgaat atcgagggac tgctggctgg ttgagacccg cgcataacca
    12061 aaaattcgca taaaaatgta ccttaaatcg aatatcagac acgatgtgtc tattatgcca
    12121 aaatgacgat ttaatggaca ctcaaacgaa gccgttttac tatgtctgat aatttataat
    12181 atttcgaacg gttgcagttg tgttaaaaaa gccgtcaggc agggaggccg atatgcccgt
    12241 tgattttttg accactgagc aggttgagag ttatggcagg ttcactggcg aacccgatga
    12301 acttcagctg gcgcgttatt ttcatcttga tgaagcggat aaagaattta tcgggaaaag
    12361 ccggggtgat cacaatcgac ttggtattgc cctgcaaatc gggtgtgtgc gttttctggg
    12421 cacttttctt actgacatga atcatattcc ttccggcgtc cggcatttta ccgccagaca
    12481 gctcgggatt cgtgatatca ccgttcttgc agaatacggt cagagggaaa atacccgccg
    12541 tgagcatgca gcgctgatac gtcagcacta tcagtatcgt gaatttgcct ggccctggac
    12601 atttcgcctt acccgtcttt tatatacccg gagctggata agcaacgaac gtcctggcct
    12661 gcttttcgac ctggcgacag ggtggcttat gcaacatcgt attattctcc ccggagccac
    12721 cacgctgacc cggttgattt cagaggtaag ggaaaaggcg acgttgcgcc tgtggaacaa
    12781 actggcactg ataccgtcag ccgaacagcg ttcacagctg gagatgctgc tggggccaac
    12841 tgattgcagc cgcctgtctt tactggaatc actgaaaaaa ggccctgtga ccatcagtgg
    12901 tccggcgttt aatgaagcaa ttgaacgctg gaaaactctg aacgattttg gcctgcatgc
    12961 tgaaaacctg agtacactcc cggctgtgcg cctgaaaaat ctcgcacgtt atgctggtat
    13021 gacttcggtg ttcaatattg ccaggatgtc accgcagaaa aggatggcgg ttctggttgc
    13081 ctttgtcctt gcatgggaaa cgctggcgct ggatgatgca ctggacgttc tggacgccat
    13141 gctggccgtt atcatccgtg acgccagaaa gattgggcag aaaaaacggc tccgctcgct
    13201 gaaggatctg gataaatctg cattggcgct cgccagcgca tgttcgtact tgctgaaaga
    13261 agaaacaccg gacgaatcga ttcgtgctga ggtgttcagc tacatcccta ggcaaaagct
    13321 ggctgaaatc atcacgcttg tccgtgaaat tgcccggccc tcagacgata attttcatga
    13381 cgaaatggtg gagcagtacg ggcgcgttcg tcgtttcctg ccccatctgc tgaataccgt
    13441 taaattttca tccgcacctg ccggggttac cactctgaat gcctgtgact acctcagccg
    13501 ggagttcagc tcacggcggc agttttttga cgacgcacca acggaaatca tcagtcagtc
    13561 atggaaacgg ctggtgatta acaaggaaaa acatatcacc cgaaggggat acacgctctg
    13621 ctttctcagt aaactgcagg atagtctgag acggagggat gtctacgtta ccggcagtaa
    13681 ccggtgggga gatcctcgtg caagattact acagggtgct gactggcagg caaatcggat
    13741 taaggtttat cgttctttgg ggcacccgac agacccgcag gaagcaataa aatctctggg
    13801 ccatcagctt gatagtcgtt acagacaggt tgctgcacgt cttggcgaaa atgaggctgt
    13861 cgaactcgat gtttctggcc cgaagccccg gttgacaatt tctcccctcg ccagtcttga
    13921 tgagccggac agtctgaaac gactgagcaa aatgatcagt gatctgctcc ctccggtgga
    13981 tttaacggag ttgctgctcg aaattaacgc ccataccgga tttgctgatg agtttttcca
    14041 tgccagtgaa gccagtgcca gagttgatga tctgcccgtc agcatcagcg ccgtgctgat
    14101 ggctgaagcc tgcaatatcg gtctggaacc actgatcaga tcaaatgttc ctgcactgac
    14161 ccgacaccgg ctgaactgga caaaagcgaa ctatctgcgg gctgaaacta tcaccagcgc
    14221 taatgccaga ctggttgatt ttcaggcaac gctgccactg gcacagatat ggggtggagg
    14281 agaagtggca tctgcagatg gaatgcgctt tgttacgcca gtcagaacaa tcaatgccgg
    14341 accgaaccgc aaatactttg gtaataacag agggatcacc tggtacaact ttgtgtccga
    14401 tcagtattcc ggctttcatg gcatcgttat accggggacg ctgagggact ctatctttgt
    14461 gctggaaggc cttctggaac aggagaccgg gctgaatcca accgaaatta tgaccgatac
    14521 ggcaggtgcc agcgatcttg tctttggcct tttctggctg ctgggatacc agttttctcc
    14581 acgcctggct gatgccggtg cttcggtttt ctggcgaatg gaccatgatg ccgactatgg
    14641 cgtgctgaat gatattgcca gagggcaatc agatccccga aaaatagtcc ttcagtggga
    14701 cgaaatgatc cggaccgcag gctccctgaa gctgggcaaa gtacaggcct cagtgctggt
    14761 ccgttcattg ctgaaaagtg aacgtccctc cggactgact caggcaatca ttgaagtggg
    14821 gcgcatcaac aaaacgctgt atctgcttaa ttatattgat gatgaagatt accgccggcg
    14881 cattctgacc cagcttaatc ggggagaaag ccgtcatgca gttgccagag ccatctgtca
    14941 cggtcaaaaa ggtgagataa gaaaacgata taccgacggt caggaagatc agttgggagc
    15001 tctggggctg gtcactaacg ccgtcgtgtt atggaacact atttatatgc aggcagctct
    15061 ggatcatctc cgggcgcagg gtgaaacact gaatgatgaa gatatcgcac gcctctcccc
    15121 gctttgccac ggacatatca atatgctcgg ccattattcc ttcacgctgg cagaactggt
    15181 gaccaaaggt catctgagac cattaaaaga ggcgtcagag gcagaaaacg ttgcttaacg
    15241 tgagttttcg ttccactgag cgtcagaccc c
//
