LOCUS       NZ_CP065753.1           6940 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP065753.1 Enterococcus faecium strain 18-465 plasmid p18-465_1,
            complete sequence.
ACCESSION   NZ_CP065753
VERSION     NZ_CP065753.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-06-07 17:10:19
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 6940
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..6940
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[1565:1940]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1566..1940
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..6940
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..6940
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             complement(55..735)
                     /locus_tag="ctg1_1"
                     /transl_table=11
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASPTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
     CDS             complement(972..1433)
                     /gene_functions="other (smcogs) SMCOG1148:hypothetical
                     protein (Score: 61.9; E-value: 1.6e-18)"
                     /gene_kind="other"
                     /locus_tag="ctg1_2"
                     /transl_table=11
                     /translation="MEDLGSKLRELRVKKGYTQEYVARKFNVTRQTISKWENNKTTPDI
                     ETLKKICEFYSTNINSILNEDNSKNKKNNLLVLTAIIFNIFVTILGLFELIQMNFFSFT
                     HGIFTWFALSGLIVIDILNYFYIYYSYLKNEKFFYTMFFPLVILIILLS"
     CDS             1566..1940
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_3"
                     /sec_met_domain="Lactococcin_972 (E-value: 4.4e-09,
                     bitscore: 28.1, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKFLCLSALMGVLLTSGGIASATEALNLDVPEDHTAIYGGGMEA
                     TEEGFSSSKLRYAAGGGDFNCGVNGFKVYANYYHARAKHSATAKNGRGGQVRSVQKAGV
                     RAYATCNATLTGNTGWWNVY"
     CDS             1994..2539
                     /locus_tag="ctg1_4"
                     /transl_table=11
                     /translation="MLKKINAVLSLFVCITILFFSTNVINGIKTSEALYKNTAEIHMQY
                     KDDMDFNSYINALYEISTQENINISQYSFTAVNQLTILATNPNANKHWKFSKKNILARN
                     DSKVHYTNNKNSKYQLKLPNNFLNINIYPFSHVENIGLSEILYVQGNSNKLIPVLKKYG
                     TPTISNMVLLQSFKSTIK"
     CDS             2577..3257
                     /locus_tag="ctg1_5"
                     /transl_table=11
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASPTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
     CDS             3414..3791
                     /locus_tag="ctg1_6"
                     /transl_table=11
                     /translation="MNGATAATPHAIAAVYISVSLVFGKSMINWADDRFGYYVMKQGPK
                     PYKPVGLAYSKNYAKSWLKHLLSYIIGTGILHLIIFLINDKSRTEAMDNVIHVWTIVII
                     IDLIICISYFVWPPKNTESKL"
     CDS             3928..4185
                     /gene_functions="other (smcogs) SMCOG1164:transposase
                     IS3/IS911 family protein (Score: 58.4; E-value: 9.3e-18)"
                     /gene_kind="other"
                     /locus_tag="ctg1_7"
                     /transl_table=11
                     /translation="MTKYSESFKEMIVDLANNGTKAKDLSSEYGISEAAIYKWKKLYTK
                     DSKTGVNEKQMQTLRKEIKQLKLENEILRKAAAIFAQDPL"
     CDS             4668..4814
                     /locus_tag="ctg1_8"
                     /transl_table=11
                     /translation="MISEQERNESKRRQTQGIKVAKEKGVYKGRPVLYSPNAKDSQKRL
                     VYY"
     CDS             5025..5153
                     /locus_tag="ctg1_9"
                     /transl_table=11
                     /translation="MMEMVFTLYKTIKVSDYLKVEGQVCTFLNRIPKSRLFTIILT"
     CDS             5296..6705
                     /gene_functions="resistance (resist) Chlor_Efflux_Pump
                     (Score: 253.4; E-value: 2.6e-77)"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 232.1; E-value:
                     1.5e-70)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_10"
                     /transl_table=11
                     /translation="MNHQNEKNIASNVLLISILGLSVLVGSVTADMVNPVLGVIGKELG
                     GSEAQVSWVVSGVALVLSIAIPFYGRLSDFLNIKKLFTNGFLILTIGSLICIFAPNLII
                     LVLGRMFQGAGMAAIPVLSIVIISKIYPPGQRGRILGIIAGCIGVGTAGGPIFGGVVGQ
                     LLGWQSLFWVTFVLGLIIVLGVQISMPKIESPDNNSHQNFDVLGGLLLGLTVGGFLLGI
                     TLSEMYGLISIQTTTSFSISMIALIVLIYRVINVKNPFIPPVILKNRLYVSSIFIVFLS
                     MFAYVSMLVFIPLLVVEVNGLSTGQAGLILLSGGVAVAILSPIVGRLSDKVHPKILLLV
                     GLIIMGLSSLYMSFVAGASPVLLSIGSLGIGIAFAFINSPVNNVAVLALPKEQVGVGTG
                     LFQGAMYLGAGTGASLIGALLSMRHGVKASFNPFYTLTAPHYSDIFLTITCIVLVALIV
                     TLNISSRDLKQ"
ORIGIN
        1 ggttctgttg caaagtttta aataaagaat aaaatccctt acggtatcta taatttaagc
       61 tgggattccc aataatacct tgatttcagt acagaccgaa aacccgaaga gagtgccttc
      121 ttttcgggtt ttcttatata atcctcggat ggcttccatg cctttaatcg tgggtgaggc
      181 agtgcgtaaa cttcgataga atttattgcg tctctttact ggacgatggt cttgttcaat
      241 caaattattc aggtatttaa tggtacgatg ttctgtccct tgataaaagc cgtattcttt
      301 tagtttctta aaggcacttg taatagaggg ggctttatct gtgactacaa ccttcggttc
      361 atcaaactgc ttcactaacc gcttaagaaa agcataggct gcttgtgtgt cccgtttttt
      421 acgtaaccaa atatccaagg ttaaaccatc tgcatcgatg gctcgataca aataatgcca
      481 ttttccttta attttgatgt acgtttcatc cattttccat gaataaaagg attttttatt
      541 tttctttttc caaatttgat agagtagttt gccatattct tgcacccaac gataaatcgt
      601 cgtatgagaa acgttaatgc cacgatcata taagatttct tgaacttcac gatagctaag
      661 gttataacga agatagtagc ccacggctac aataatcaca tcctgctgaa attgctttcc
      721 tttaaaatga ttcatcgtca ttcctcctgc tatctttttc tattattcta ccttatttga
      781 tagtagattt aaaactttgc aacagaaccg aattagatat agataaccgc gaaaaatcaa
      841 gctttagaaa gttgctttta gctagaccaa ttaaaaatca caaagtgagc gtctctatcc
      901 attggtagag gggctacttg gcatagtcga cattatgtca actatgcaat taaataacta
      961 actacttcat attagcttaa taaaataatc aaaataacta gggggaaaaa cattgtataa
     1021 aaaaattttt cattttttaa ataagaatag taaatataaa aataatttaa gatatctatt
     1081 actattaatc cagatagagc aaaccaagta aatattccat gtgtaaagct aaaaaaattc
     1141 atttgaatca attcaaataa acctaatata gtaacaaata tattaaaaat aatagctgtc
     1201 aataccagta aattattttt tttatttttt gaattatctt catttaaaat agaatttatg
     1261 ttagtactat aaaattcaca aatttttttt agtgtctcta tatctggtgt tgttttgtta
     1321 ttttcccact ttgaaatagt ttgacgtgta acgttaaatt ttcttgccac atattcttga
     1381 gtataccctt ttttcactct taattctctt agcttagatc ctaaatcctc cattttttct
     1441 cctatgtaaa cgattattta cataaaattt tatcataaaa atactaacgc gccaaaaaag
     1501 ttctttattt tataaaacac actaaaataa aataattcta gtaaaaaaga taggagaaat
     1561 aagttatgaa aaaattttta tgtctttctg ctttaatggg tgtcttatta actagtggag
     1621 gaatagctag tgccacagaa gctttaaatc tagatgtacc cgaagaccat accgccattt
     1681 acggaggagg aatggaagct acagaagaag gattttcttc tagtaaattg agatatgctg
     1741 ctggcggcgg ggatttcaac tgtggggtta atggatttaa agtttatgca aattactacc
     1801 atgctagagc taaacatagt gcaacagcta aaaatggacg aggcggtcaa gtacgatcag
     1861 ttcagaaagc tggagtaaga gcttatgcaa catgcaatgc cacacttact ggaaatactg
     1921 gttggtggaa tgtttattaa aaaagagagt ttaaactctc ttttttattt acatttgaaa
     1981 ggaaattcaa aatatgttaa aaaaaataaa cgctgtttta tcactttttg tctgcattac
     2041 aatactattt ttttctacta atgttataaa tggtataaag acttctgaag cgctatataa
     2101 aaataccgct gaaattcata tgcaatataa agatgatatg gactttaaca gttatataaa
     2161 cgctttgtat gaaatatcta cacaagaaaa tattaatatt tctcaatata gttttactgc
     2221 tgttaaccaa ctaactattc ttgctacaaa ccctaacgct aacaaacact ggaaattttc
     2281 taaaaaaaat atattagcaa gaaacgattc taaagtccat tatactaata acaaaaattc
     2341 taagtaccaa ttaaaacttc caaataattt tttaaatata aatatttatc ctttttctca
     2401 tgtggaaaat attggattaa gtgaaatatt atatgtacaa ggaaactcaa acaaattaat
     2461 tcctgtactg aaaaaatatg gaacacctac tatttccaat atggttctgt tgcaaagttt
     2521 taaatctact atcaaataag gtagaataat agaaaaagat agcaggagga atgacgatga
     2581 atcattttaa aggaaagcaa tttcagcagg atgtgattat tgtagccgtg ggctactatc
     2641 ttcgttataa ccttagctat cgtgaagttc aagaaatctt atatgatcgt ggcattaacg
     2701 tttctcatac gacgatttat cgttgggtgc aagaatatgg caaactactc tatcaaattt
     2761 ggaaaaagaa aaataaaaaa tccttttatt catggaaaat ggatgaaacg tacatcaaaa
     2821 ttaaaggaaa atggcattat ttgtatcgag ccatcgatgc agatggttta accttggata
     2881 tttggttacg taaaaaacgg gacacacaag cagcctatgc ttttcttaag cggttagtga
     2941 agcagtttga tgaaccgaag gttgtagtca cagataaagc cccctctatt acaagtgcct
     3001 ttaagaaact aaaagaatac ggcttttatc aagggacaga acatcgtacc attaaatacc
     3061 tgaataattt gattgaacaa gaccatcgtc cagtaaagag acgcaataaa ttctatcgaa
     3121 gtttacgcac tgcctcaccc acgattaaag gcatggaagc catccgagga ttatataaga
     3181 aaacccgaaa agaaggcact ctcttcgggt tttcggtctg tactgaaatc aaggtattat
     3241 tgggaatccc agcttaaatt atagataccg taagggattt tattctttat ttaaaacttt
     3301 gcaacagaac cgtaacaaga tatatcttaa aacaaaaaac actaggtcta tttttcctag
     3361 cacttacacc agttatagat ttaatattac ttataacaac aggtatagac ctcatgaatg
     3421 gagcaacagc tgcaacccct catgctatag ctgcggtcta tatttcagta tctcttgtct
     3481 ttgggaaaag catgataaat tgggcagatg atagatttgg atattatgtg atgaaacaag
     3541 gacccaaacc ttacaaacct gtaggattag cttactctaa aaactatgct aaaagttggt
     3601 tgaaacattt actttcttac attataggaa caggtatttt gcatttgatt atttttttaa
     3661 ttaatgataa aagtcgtaca gaagctatgg ataatgttat tcatgtttgg acaattgtca
     3721 ttattattga cttaatcatt tgtatttcat attttgtgtg gccaccaaaa aatacggaaa
     3781 gtaaattatg attacaattt taaaaaaaga aaatactgac gttttgaact gacctcaatt
     3841 agtgggagtt ggtgctagta tgaaaattag gacgcctttt cgtagagtct tgaatcaaat
     3901 ataatgagac taaggaaggt gtctaaaatg acaaagtaca gtgaatcttt taaagaaatg
     3961 attgttgatt tagctaataa tgggacaaaa gcgaaggatt taagtagcga gtatggcatt
     4021 tcagaagcag ccatttataa atggaaaaaa ttatacacga aagactctaa aaccggtgtt
     4081 aatgaaaaac aaatgcaaac ccttagaaaa gaaataaaac aacttaaact cgaaaatgaa
     4141 atactaagaa aggcagccgc catattcgct caagatccac tttaactaaa gtccgttgga
     4201 ttaaacgcta ttcaaaaatc tttaatgcca gccatctatg ccgcatatta aatgttccaa
     4261 gaagcttata ttattactgt attaaagaga aatattctgt tagaaatgag agactccttc
     4321 gttttaaagt tttaatcaaa gccttatacc atcaatataa tggcatctat ggtgcgccta
     4381 aaatccacgc ttttttgaca caaaaaggct ataatgtttc tgttaagtat gttcaaaaaa
     4441 tcatgcggtt acttggcatt acttctgtta ccattaaaaa attcaaacac tatactaatt
     4501 ccaaagttaa aggtgtcttt aaaaatatgc tgaaaagtat gatgctatct atcttaaaga
     4561 atgcaaccat cctaatgaaa tttggcaagc agatcatact atgttagata tagaggtttt
     4621 aaacgaaaaa aacaaacttg aaagaccttg gctaactgtt gtcttagatg atttcagaac
     4681 aagaaagaaa tgagagtaaa cgtcggcaaa cgcaagggat taaagtagcg aaagaaaaag
     4741 gagtatacaa aggacgacct gtactttatt caccaaatgc aaaagattct caaaaacgtt
     4801 tagtttatta ctgagttata gaaatgttag acaaatgttt ttcaattagc aatatagtta
     4861 cggaagtaga tgttactaga caaactatat agagtattaa aaataatcaa ataaactcat
     4921 aattttaaaa tttactactc tattttgctc aaaatagaga taaaactgac aaatttactc
     4981 ttttgtgtta ttttggtata gattaatata agaggaggat aaaaatgatg gaaatggtgt
     5041 ttacccttta taaaacaatt aaagtttcag actatctcaa agttgaggga caagtatgta
     5101 cttttttaaa cagaatacca aaatccagac tttttactat aatccttacg taaaaaagta
     5161 aaatattgat ttatgtaaca aaagtctgat cttaagatta ggttttttat ttggataatt
     5221 gagaggtgaa attgatggtt aaagcagtcg atttagcctt ctaaaatgag catttaaatt
     5281 ttaggaggct gtaaaatgaa tcatcaaaat gaaaaaaata tagcatcaaa tgtgttgtta
     5341 attagtatct taggcttgtc tgttttagtg ggttcagtta ctgcagatat ggttaatcct
     5401 gttctcggtg tgattggaaa agaattaggt gggtctgagg cgcaagttag ttgggtcgta
     5461 agtggtgttg ccttagttct atctatagca attccctttt atggacgttt atctgatttt
     5521 ttaaatatta aaaaactctt tactaacgga tttctaatat taactatagg aagtttaata
     5581 tgtatattcg cgcccaattt aattatttta gtattgggta gaatgtttca aggagctggc
     5641 atggcagcca tacctgtgct atctattgtt ataatatcta aaatttatcc gcctggacag
     5701 agaggaagaa ttttaggtat tattgctggt tgtattggcg ttggcactgc aggaggccca
     5761 atatttggcg gcgttgtagg acaattatta ggttggcaat cattattttg ggtcactttt
     5821 gttctgggtt taattatagt tctaggtgtt caaatatcaa tgcctaaaat agaatcacca
     5881 gataataaca gtcatcaaaa ttttgatgtt ttaggtggac tattattagg attaaccgta
     5941 ggtggttttt tacttggtat tacgctttca gaaatgtatg gtttgatttc tatacaaaca
     6001 accacaagtt tttctatatc tatgatagct ttaatagtgt taatatatcg cgtgattaat
     6061 gttaaaaatc cttttatccc tccagttata ttgaagaacc gtttatatgt aagctcaatt
     6121 ttcattgtat ttctttcaat gtttgcttat gtctctatgc ttgtttttat tccattatta
     6181 gttgttgagg ttaatgggtt aagtactgga caggcaggct taatattact ttctggtggt
     6241 gtcgctgttg caatcctttc accaatagtg ggaagattat ctgacaaagt gcatcctaaa
     6301 atactattat tagttggact aattattatg ggcttatctt ctttatatat gagcttcgta
     6361 gcaggcgcat cacctgtatt attatctatc gggagtttag ggataggtat cgcttttgca
     6421 tttattaact ctccagtgaa taatgttgca gtacttgctt tacctaaaga acaagttggt
     6481 gtaggtacgg ggttgtttca aggtgcaatg tatcttgggg caggaacagg tgcctcacta
     6541 ataggggctt tattgtcaat gagacatggg gttaaagcat cttttaatcc tttttatact
     6601 ttaactgccc cgcactattc tgatatattt ttaaccatta cgtgcatcgt gttagttgct
     6661 ttaattgtta ctttaaatat aagtagtagg gatttaaagc aataaaacct ttttattaca
     6721 cagatataca tctgttttta aatattattc agaaactaaa ttgttaatag caagaacaac
     6781 taaataattt taaaaaacag ggcttattaa caagccctgt tttgcatttt agccaagaaa
     6841 ataaccagtt tctgtacact atctaactat cacttttttc aattcataat attgtatagc
     6901 attccatacg tttcattttc tcatttatta agtaaaatca
//
