LOCUS       NZ_CP064052.1           5973 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP064052.1 Enterococcus faecium strain VRE3370 plasmid unnamed3,
            complete sequence.
ACCESSION   NZ_CP064052
VERSION     NZ_CP064052.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-06-07 14:45:25
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 33706
            Orig. end    :: 39679
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..5973
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:5225]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5225
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..5973
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..5973
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             105..890
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="resistance (resist) APH3' (Score: 367.3;
                     E-value: 3.3e-112)"
                     /gene_kind="other"
                     /locus_tag="ctg1_46"
                     /sec_met_domain="APH (E-value: 9.3e-29, bitscore: 92.8,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRISPELKKLIEKYRCVKDTEGMSPAKVYKLVGENENLYLKMTDS
                     RYKGTTYDVEREKDMMLWLEGKLPVPKVLHFERHDGWSNLLMSEADGVLCSEEYEDEQS
                     PEKIIELYAECIRLFHSIDISDCPYTNSLDSRLAELDYLLNNDLADVDCENWEEDTPFK
                     DPRELYDFLKTEKPEEELVFSHGDLGDSNIFVKDGKVSGFIDLGRSGRADKWYDIAFCV
                     RSIREDIGEEQYVELFFDLLGIKPDWEKIKYYILLDELF"
     CDS             1640..2377
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="resistance (resist) ErmB (Score: 567.5;
                     E-value: 1.8e-173)"
                     /gene_kind="other"
                     /locus_tag="ctg1_47"
                     /sec_met_domain="PCMT (E-value: 8.5e-07, bitscore: 20.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKNIKYSQNFLTSEKVLNQIIKQLNLKETDTVYEIGTGKGHLTT
                     KLAKISKQVTSIELDSHLFNLSSEKLKLNTRVTLIHQDILQFQFPNKQRYKIVGNIPYH
                     LSTQIIKKVVFESRASDIYLIVEEGFYKRTLDIHRTLGLLLHTQVSIQQLLKLPAECFH
                     PKPKVNSVLIKLTRHTTDVPDKYWKLYTYFVSKWVNREYRQLFTKNQFHQAMKHAKVNN
                     LSTVTYEQVLSIFNSYLLFNGRK"
     CDS             2322..2462
                     /locus_tag="ctg1_48"
                     /transl_table=11
                     /translation="MSKYCLFLIVIYYLTGGNNSMSRFCKFGKLHVTKGNVDKLLGIGH
                     L"
     CDS             complement(2640..3503)
                     /locus_tag="ctg1_49"
                     /transl_table=11
                     /translation="MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSG
                     KTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELVKLYEKDVVKHVTPYSNRMTEAIIS
                     RLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYETMY
                     ADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISP
                     KETLEKELNRKVSGKEIQPTLERIEQKMVLNKHQETPEFKAIQQKLESLQPPTPPIPKT
                     PKLPGI"
     CDS             complement(3505..3777)
                     /locus_tag="ctg1_50"
                     /transl_table=11
                     /translation="MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVN
                     LLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYSKQVLNKEKVA"
     CDS             complement(3794..4009)
                     /locus_tag="ctg1_51"
                     /transl_table=11
                     /translation="MIVGNLGAQKAKRNDTPISAKKDIMGDKTVRVRADLHHIIKIETA
                     KNGGNVKEVMDQALEEYIRKYLPDKL"
     CDS             complement(4168..4854)
                     /locus_tag="ctg1_52"
                     /transl_table=11
                     /translation="MTMNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVS
                     HTTIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDI
                     WLRKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKY
                     LNNLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKV
                     LLGIPA"
     CDS             5001..5225
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_II"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_53"
                     /sec_met_domain="Bacteriocin_II (E-value: 8.7e-22,
                     bitscore: 68.5, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKVLKHCVILGILGTCLAGIGTGIKVDAATYYGNGLYCNKEKC
                     WVDWNQAKGEIGKIIVNGWVNHGPWAPRR"
     CDS             5185..5532
                     /locus_tag="ctg1_54"
                     /transl_table=11
                     /translation="MVGLIMVHGHLEGSGREVIIMDFTKEEKLLNAISKVYNEATIDDY
                     PDLKEKLFLYSKEISEGKSVGEVSMKLSSFLGRYILKHKFGLPKSLIELQEIVSKESQV
                     YRGWASIGIWS"
ORIGIN
        1 tagaatgcaa ggaacagtga attggagttc gtcttgttat aattagcttc ttggggtatc
       61 tttaaatact gtagaaaaga ggaaggaaat aataaatggc taaaatgaga atatcaccgg
      121 aattgaaaaa actgatcgaa aaataccgct gcgtaaaaga tacggaagga atgtctcctg
      181 ctaaggtata taagctggtg ggagaaaatg aaaacctata tttaaaaatg acggacagcc
      241 ggtataaagg gaccacctat gatgtggaac gggaaaagga catgatgcta tggctggaag
      301 gaaagctgcc tgttccaaag gtcctgcact ttgaacggca tgatggctgg agcaatctgc
      361 tcatgagtga ggccgatggc gtcctttgct cggaagagta tgaagatgaa caaagccctg
      421 aaaagattat cgagctgtat gcggagtgca tcaggctctt tcactccatc gacatatcgg
      481 attgtcccta tacgaatagc ttagacagcc gcttagccga attggattac ttactgaata
      541 acgatctggc cgatgtggat tgcgaaaact gggaagaaga cactccattt aaagatccgc
      601 gcgagctgta tgatttttta aagacggaaa agcccgaaga ggaacttgtc ttttcccacg
      661 gcgacctggg agacagcaac atctttgtga aagatggcaa agtaagtggc tttattgatc
      721 ttgggagaag cggcagggcg gacaagtggt atgacattgc cttctgcgtc cggtcgatca
      781 gggaggatat cggggaagaa cagtatgtcg agctattttt tgacttactg gggatcaagc
      841 ctgattggga gaaaataaaa tattatattt tactggatga attgttttag tacctagatt
      901 tagatgtcta aaaagcttta actacaagct ttttagacat ctaatctttt ctgaagtaca
      961 tccgcaactg tccatactct gatgttttat atcttttcta aaagttcgct agataggggt
     1021 cccgagcgcc tacgaggaat ttgtatcgat aagaaataga tttaaaaatt tcgctgttat
     1081 tttgtacatt taacttgacg gtgacatctc tctattgtga gttattagtg gtacagtttt
     1141 caaccgtttt aattataaaa aagtggtgca tttttaaatt ggcacaaaca ggtaacggtt
     1201 attgcaggtg tatttcttat ctatgggttt aacatggatt ttatcattaa aatcatgagt
     1261 attgtccgag agtgattggt cttgcgtatg gttaacccta aagttatgga aataagactt
     1321 agaagcaaac ttaagagtgt gttgatagtg cattatctta aaattttgta taataggaat
     1381 tgaagttaaa ttagatgcta aaaatttgta attaagaagg agggattcgt catgttggta
     1441 ttccaaatgc gttatgtaga taaaacatct actgttttga aacagactaa aaacagtgat
     1501 tacgcagata aataaatacg ttagattaat tcctaccagt gactaatctt atgacttttt
     1561 aaacagataa ctaaaattac aaacaaatcg tttaacttct gtatttgttt atagatgtaa
     1621 tcacttcagg agtgataaca tgaacaaaaa tataaaatat tctcaaaact ttttaacgag
     1681 tgaaaaagta ctcaaccaaa taataaaaca attgaattta aaagaaaccg ataccgttta
     1741 cgaaattgga acaggtaaag ggcatttaac gacgaaactg gctaaaataa gtaaacaggt
     1801 aacgtctatt gaattagaca gtcatctatt caacttatcg tcagaaaaat taaaactgaa
     1861 tactcgtgtc actttaattc accaagatat tctacagttt caattcccta acaaacagag
     1921 gtataaaatt gttgggaata ttccttacca tttaagcaca caaattatta aaaaagtggt
     1981 ttttgaaagc cgtgcgtctg acatctatct gattgttgaa gaaggattct acaagcgtac
     2041 cttggatatt caccgaacac tagggttgct cttgcacact caagtctcga ttcagcaatt
     2101 gcttaagctg ccagcggaat gctttcatcc taaaccaaaa gtaaacagtg tcttaataaa
     2161 acttacccgc cataccacag atgttccaga taaatattgg aagctatata cgtactttgt
     2221 ttcaaaatgg gtcaatcgag aatatcgtca actgtttact aaaaatcagt ttcatcaagc
     2281 aatgaaacac gccaaagtaa acaatttaag taccgttact tatgagcaag tattgtctat
     2341 ttttaatagt tatctattat ttaacgggag gaaataattc tatgagtcgc ttttgtaaat
     2401 ttggaaagtt acacgttact aaagggaatg tagataaatt attaggtata gggcacctct
     2461 aataactacc aattaattca cctcaaaatg aaattagaaa aaaacagcga aatttttaaa
     2521 tctatttctt atcgatacaa attcctcgta ggcgctcggg accccaacat gaggaaatgt
     2581 ttttataaaa aaagagtagt taccgttttt tggtaactac tcttttcctt ttttaaggtt
     2641 taaatacctg gaagtttagg tgttttgggt attggtggtg taggtggctg caagctttcc
     2701 aatttttgtt gaattgcttt aaattcaggt gtctcttggt gtttatttag aaccattttt
     2761 tgctctattc gttctaaagt cggttgaatt tctttccctg atactttacg attcaattct
     2821 ttttctaagg tttcttttgg actaatagaa ggtgtttcca aacttgaata gagttttact
     2881 ccttctctgt tatatagcct tatatcgcta aataagcccg ttttatgaag ggtttctaaa
     2941 ttggtcggta agtttttgac aacaatatca tgcgcttgtt ttggtgttgc cctggctgtc
     3001 attggatcat ctgcatacat ggtttcatat cgttcaattg ttcctaaata tgagttgatt
     3061 ttaggtactg ccatgacata catttttgtt tcataacctt tggcttgaag cattgttgcg
     3121 gtttgaatag gaacgtctgt tgttcgtcct gtaccttcga tcaccaaatt atacccttga
     3181 tcgctcaaac ggcttatgat cgcttctgtc atgcgattag aataaggggt aacgtgtttt
     3241 actacgtctt tttcataaag tttcactagt tcatcaaaat tagggtgctg ttgtttaaag
     3301 gtatcattat caatgacaat aacattccct tgtgtttctt caaaaattgc tgatcgcaaa
     3361 ctggttttcc ctgaccctgg ttgcccacca agtaaaaaag cggttggcga ttcaaccgct
     3421 ttttttcctt gaatcaattc ttctaaatta tcatttaagc gattctcaaa ttgtttgtca
     3481 gtaaaattga ctatatttgc catattaagc cactttctct ttattcaaaa cttgttttga
     3541 gtaacgattc attgaccgcc aatactcatg aacggcttgt aattcttcta aagaataatc
     3601 aaaaagattt acacgttttg caagctttaa ttggtttaat aaattgactt ccaataattg
     3661 agagtcattt ttatttaatt catggttcaa aacatagttt aatactcgat tataaacgct
     3721 tgccgataat tcgttaatga tctctatttc aaatgttttt tcatacgtaa ctgccatttc
     3781 attttcactc cttttaaagt ttgtcaggta aatatttccg tatatattct tctaaggctt
     3841 gatccataac ttcttttacg tttccgccat tctttgctgt ttcgattttt atgatatggt
     3901 gcaagtcagc acgaacacga accgtcttat ctcccattat atcttttttt gcactgattg
     3961 gtgtatcatt tcgttttgct ttttgtgcgc ctaaatttcc cacaatcact cacttctttc
     4021 tatttcttct tactcttatt ttatcatcaa caatcacaaa tcacaagtga tttgtgatta
     4081 atcacttgtg atttgtgatt ctattctttt tcgggttctg ttgcaaagtt ttaaataaag
     4141 aataaaatcc cttacggtat ctatgattta agctgggatt cccaataata ccttgatttc
     4201 agtacagacc gaaaacccga agagagtgcc ttcttttcgg gttttcttat ataatcctcg
     4261 aatggcttcc atgcctttaa tcgtggtaga ggcagtgcgt aaacttcgat agaatttatt
     4321 gcgtctcttt actggacgat ggtcttgttc aatcaaatta ttcaggtatt taatggtacg
     4381 atgttctgtc ccttgataaa agccgtattc ttttagtttc ttaaaggcac ttgtaataga
     4441 gggggcttta tctgtgacta caaccttcgg ttcatcaaac tgcttcacta accgcttaag
     4501 aaaagcatag gctgcttgtg tgtcccgttt tttacgtaac caaatatcca aggttaaacc
     4561 atctgcatcg atggctcgat acaaataatg ccattttcct ttaattttga tgtacgtttc
     4621 atccattttc catgaataaa aggatttttt atttttcttt ttccaaattt gatagagtag
     4681 tttgccatat tcttgcaccc aacgataaat cgtcgtatga gaaacgttaa tgccacgatc
     4741 atataagatt tcttgaactt cacgatagct aaggttataa cgaagatagt agcccacggc
     4801 tacaataatc acatcctgct gaaattgctt tcctttaaaa tgattcatcg tcattcctcc
     4861 tgctatcttt ttctattatt ctaccttatt tgatagtaga tttaaaactt tgcaacagaa
     4921 cctaaaatgt tatataataa aattactaag attatttaat ataacaagca attttaaaaa
     4981 aacgaaaagg aaaaacaatc atgaaaaaga aagtattaaa acattgtgtt attctaggaa
     5041 tattaggaac ttgtctagct ggcatcggta caggaataaa agttgatgca gctacttact
     5101 atggaaatgg tctttattgt aacaaagaaa aatgttgggt agattggaat caagctaaag
     5161 gagaaattgg aaaaattatt gttaatggtt gggttaatca tggtccatgg gcacctagaa
     5221 ggtagtggta gggaggttat tataatggat tttactaaag aagaaaaact tttaaatgca
     5281 attagtaaag tatacaatga agcaactata gatgactatc ctgacttaaa agaaaagctc
     5341 tttctttatt ctaaagaaat cagtgaggga aaaagtgttg gtgaagttag tatgaaatta
     5401 agtagttttc ttggaagata tattttaaaa cataaatttg gattacctaa atctttaata
     5461 gaattacaag aaattgttag taaggaatct caagtatata gaggatgggc ttctattggt
     5521 atttggagtt aattctttgg aataaaatga aaatgggact gaagaatcaa ttctgattca
     5581 tcagtcccat aaattataga gccgaaaaat tatcatattt atagatttat taatagtaaa
     5641 tggcataaga atctttgaac aacgaaaaaa atgtagctct acctaattat tgatttgcaa
     5701 caatttcacc gaaggtgaaa caagcgaaac tttacaaaaa gtggctagca tttgctagtc
     5761 ttttttgtat tgtggagagt gggggggagg gggattcaag ggggagcttg cgcccctttg
     5821 acaagcggtt atttgcacca aatacgtagg tatttggcta gcaaatatag agcttgccaa
     5881 gccctttagt gagctttagt gagctttact tattgtacct ttttaggtac aatggtattg
     5941 cgaacgatac gtccgtagga cgtactgaaa ggg
//
