LOCUS       NZ_CP049848.1          17770 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP049848.1 Escherichia coli strain UPEC-245U/190328 plasmid
            pEcoUTI1d, complete sequence.
ACCESSION   NZ_CP049848
VERSION     NZ_CP049848.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-06-07 14:56:09
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17770
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..858
                     /locus_tag="ctg1_1"
                     /transl_table=11
                     /translation="MTDLQQTYYRQVKNPNPVFTPRKGAGTLKFCEKLMEKAVGFTSRF
                     DFAIHVAHARSRGLRRRMPPVLRRRAIDALLQGLCFHYDPLANRVQCSITTLAIECGLA
                     TESGAGKLSITRATRALTFLSELGLITYQTEYDPLIGCYIPTDITFTPALFAALDISEE
                     AVASARRSRVEWENRQRKKQGLDTLGMDELIAKAWRFVRERFRSYQTELKSRGIKRARA
                     RRDANRERQDIVTLVKRQLTREISEGRFSASREAVKREVERRVKERMILSRNRNYSRLA
                     TASP"
     protocluster    1..17770
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5780:7770]"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5781..7770
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
     cand_cluster    1..17770
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /kind="single"
                     /product="LAP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17770
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="LAP"
                     /region_number="1"
                     /rules="((((goadsporin_like or PF00881 or TIGR03605) and
                     (YcaO or TIGR03604)) or TIGR03882 or TIGR03603 or
                     TIGR03602) and not cyanobactin_synth)"
                     /tool="antismash"
     CDS             1928..2191
                     /locus_tag="ctg1_2"
                     /transl_table=11
                     /translation="MNSTTHYENANFLRELAESLPRIFPEGSTDKSALLQRLANEELAR
                     AEYDEQIRAKVAAARADKRPGMSSAQLRQQLQGRYQELRNEL"
     CDS             2181..2480
                     /locus_tag="ctg1_3"
                     /transl_table=11
                     /translation="MSYEIEWRPGAIEDITALFEYLVENASLWDARNVTERLITATDRL
                     ADYPRLYETDERYGEGVRRISLLGQHVLYEVNDEASRVNILAVVGQRQNPRFIL"
     CDS             complement(2516..3181)
                     /locus_tag="ctg1_4"
                     /transl_table=11
                     /translation="MMFWNRNKKDKATIANEKKRFNHLLSVAEKLPVKALPDLIRAIVR
                     PVQSDFLLAVAEEGTDARPDMTPQEFFFKGLTQIQSYEKMKECEMNGADYPLSLASDIV
                     LPWPWSLPRYIDNVSRIGTHKGKPWKQDKNNHYVDLWLPWRIGFVHGGNHSITAGILAG
                     EGSLIPEHVYDMSWMFELVRTDGNNWFVEGQKAEAVKSGRSAAVFEIGRLLVEGAKER"
     CDS             complement(3751..4314)
                     /locus_tag="ctg1_5"
                     /transl_table=11
                     /translation="MDIIEKRITKRHLSESELSGVNYYNCIFERIQLDNFNFRDCEFEK
                     CRFVNCSIKNLKLNFFKLIDCEFKDCLLQGVNAADIMFPCTFSLVNCDLRFVDFISLRL
                     QKSIFLSCRFRDCLFEETDLRKSDFTGSEFNNTEFRHSDLSHCDFSMTEGLDINPEINR
                     ILSIKIPQEAGLKILKRMGVVVGG"
     CDS             complement(4318..5049)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 95.1; E-value:
                     9.3e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_6"
                     /transl_table=11
                     /translation="MTIPLLEINSLSFSYKVNLPPVFNNLSLKIEQGELIGLLGENGAG
                     KTTLFNLIRGGVSNYEGTLKRNFSGGELVSLPQVINLSGTLRNEEVLDLICCFNKLTKK
                     QAWTELNHKWNDNFFIRYDKIRRKRTYTVSYGEKRWLIISLMLTLCKNARLFLLDEPTV
                     GIDIQYRMMLWELINKITADGKTVFFSTHIFDELTRDKIPFYMLSKNSINRYSDMSDFI
                     QSNNETTPEKAFIKEVMGTGD"
     CDS             complement(5046..5771)
                     /locus_tag="ctg1_7"
                     /transl_table=11
                     /translation="MVTLKMAIIFLMEQIRTPFSLIWTIMSPTVLFFFLHFNEIELHYG
                     DTAWLGKQISWFVGYISFSVVLFNYCLYLVGRRESGFIATFVHNMDGRLLFIRSQLIAS
                     LIMSILYVFFFILVVLTGFQASPDYQIVMIILKSIYINAFMMVSLTFMASFRVTFQTAS
                     TIYSVLITVCMVSGIVSLKYNEGIVYWINQVNPIAIYSTILQSDQELSLMTIFFYSIML
                     IISIISALTFKTEPVWSSQ"
     CDS             complement(5781..6971)
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_8"
                     /sec_met_domain="YcaO (E-value: 1.1e-16, bitscore: 53.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINVYSNLMSAWPATMAMSPKLNRNMPTFSQIWDYERITPASAAG
                     ETLKSIQGAIGEYFERRHFFNEIVTGGQKTLYEMMPPSAAKAFTEAFFQISSLTRDEII
                     THKFKTVRAFNLFSLEQQEIPAVIIALDNITAADDLKFYPDRDTCGCSFHGSLNDAIEG
                     SLCEFMERQSLLLYWLQGKANTEISSEIVTGINHIDEILLALRSEGDIRIFDITLPGAP
                     GHAVLTLYGTKNKISRIKYSTGLSYANSLKKALCKSVVELWQSYICLHNFLIGGYTDDD
                     IIDSYQRHFMSCNKYESFTDLCENTVLLSDDVKLTLEENITSDTNLLNYLQQISDNIFV
                     YYARERVSNSLVWYTKIVSPDFFLHMNNSGAININNKIYHTGDGIKVRESKMVPFP"
     CDS             complement(6952..7770)
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     PF00881"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_9"
                     /sec_met_domain="PF00881 (E-value: 8.6e-10, bitscore: 31.3,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKHELSLVEVTHYTDPEVLAIVKDFHVRGNFASLPEFAERTFVS
                     AVPLAHLEKFENKEVLFRPGFSSVINISSSHNFSRERLPSGINFCDKNKLSIRTIEKLL
                     VNAFSSPDPGSVRRPYPSGGALYPIEVFLCRLSENTENWQAGTNVYHYLPLSQALEPVA
                     TCNTQSLYRSLSGGDSERLGKPHFALVYCIIFEKALFKYRYRGYRMALMETGSMYQNAV
                     LVADQIGLKNRVWAGYTDSYVAKTMNLDQRTVAPLIVQFFGDVNDDKCLQ"
     CDS             complement(7772..8626)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04424"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_10"
                     /sec_met_domain="TIGR04424 (E-value: 2.2e-88, bitscore:
                     288.9, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINILPFEIISRNTKTLLITYISSVDITHEGMKKVLESLRSKQGI
                     ISEYLLDKLLDESLIDKDKGKEFLITTGVINKTKTSPLWVNSVIISDVPHLFSNAREQW
                     KSDGVFVSHIIDIKDNNINVSDSTLIWLHLENYHSDIVKRIYSKFESNPGVAFIQSYYL
                     KESFRIDGVYSPDLGTPCHFCHIERWLSREEKSFRRNEMSWANLLQLLKKYQMTLPALA
                     LGESERGFSYHLIKRRLQELTGTSLVKSHVDNFMSSVSADLITCILCKEPVIHWQACSC
                     LER"
     CDS             complement(8686..8883)
                     /locus_tag="ctg1_11"
                     /transl_table=11
                     /translation="MELKASEFGVVLSVDALKLSRQSPLGVGIGGGGGGSCGGQGGGCG
                     GCSNGCSGGNGGSGGSGSHI"
     CDS             9413..9865
                     /locus_tag="ctg1_12"
                     /transl_table=11
                     /translation="MKFMECAVRDVIYGTNVRIVKPVNIYECELRDNVFVGPFVEIQKG
                     CVIGSGSRIQSHTFICENVTLGENCFIGHNVTFANDLFRSGAPDPSPDNWISITLGDSV
                     TVGSGAIILSPYICSGAVIGAGAVVVKPIENKGIYAGNPARLIRIL"
     CDS             complement(10268..10621)
                     /locus_tag="ctg1_13"
                     /transl_table=11
                     /translation="MMDKRRTIAFKLNPDVNQTDKIVCDTLDSIPQGERSRLNRAALTA
                     GLALYRQDPRAPFLLCELLTKETTFSDIVNILRSLFPKEMADLNSSTIIQSSSQSEQKS
                     DEETKKNAMKLIN"
     CDS             complement(10621..11583)
                     /locus_tag="ctg1_14"
                     /transl_table=11
                     /translation="MLVFIDDGSTNIKLQWQESDGTIKQHISPNSFKREWAVSFGDKKV
                     FNYTLNGEQYSFDPISPDAVVTTNIAWQYSDVNVVAVHHALLTSGLPVSEVDIVCTLPL
                     TEYYDRNNQPNTENIERKKANFRKKITLNGGDTFTIKDVKVMPESIPAGYEVLQELDEL
                     DSLLIIDLGGTTLDISQVMGKLSGISKIYGDSSLGVSLVTSAVKDALSLARTKGSSYLA
                     DDIIIHRKDNNYLKQRINDENKISIVTEAMNEALRKLEQRVLNTLNEFSGYTHVMVIGG
                     GAELICDAVKKHTQIRDERFFKTNNSQYDLVNGMYLIGN"
     CDS             12094..13020
                     /locus_tag="ctg1_15"
                     /transl_table=11
                     /translation="MPNWCSNRMYFSGEPAQIAEIKRLASGAVTPLYRRATNEGIQLFL
                     AGSAGLLQITENIRSEQCPGVTAAGRGAVSPENIAFTRWLTHLQNGVLLDEQNCLMLHE
                     LWLQSGTGQRRWEELPDDVRETITVHFTAKRGDWCDIWGNEDVSVWWNRLCDNVLPEKT
                     MPFDLLTVLPTRLDIEVNGFNGGVLNGVPSAYHWYTERYGVKWPCGYDLNISSQGENFI
                     QVDFDTPWCQPESDVVAELSRRFGCTLEHWYAEQGCNFCGWQLYERGELVDVLWGELEW
                     SSPTDDDELPEVTGPAWIVDNVTHYGG"
     CDS             13405..14088
                     /locus_tag="ctg1_16"
                     /transl_table=11
                     /translation="MSRFILGDCVRVMATFPGNAVDFILTDPPYLVGFRDRSGRTIAGD
                     KTDEWLQPACNEMYRVLKKDALMVSFYGWNRVDRFMAAWKNAGFSVVGHLVFTKTYTSK
                     AAYVGYRHECAYILAKGRPALPQKPLPDVLGWKYSGNRHHPTEKPVTSLQPLIESFTHP
                     NAIVLDPFAGSGSTCVAALQSGRRYIGVELLEQYHRAGQQRLAAVQRAMQQGAANDNWF
                     EPEAA"
     CDS             14089..14310
                     /locus_tag="ctg1_17"
                     /transl_table=11
                     /translation="MNYAGHEKLRADVAEVANTMCDLRARLNDMEHRCRFDSDVLVERL
                     TRQTLYRANRLFMEAYTEILELDSCFKD"
     CDS             14324..14758
                     /locus_tag="ctg1_18"
                     /transl_table=11
                     /translation="MYGTCETLCRALAAKYPGDTPLMLVIWSPEEIQALADGMDISLSD
                     HEIRTVLARLEDIPEDQRTESGISSGAAMEIINNVRENRQVTVPAELLASLIQTAEQAL
                     WKREWAARDHGLAVPECVTRRQAVVNQVRILLKNNTHEND"
     CDS             14803..15573
                     /locus_tag="ctg1_19"
                     /transl_table=11
                     /translation="MNETLNALIYRHASNLLLAQGWPEETDVDQRNPKYPGWISIYVRL
                     DAPRLATLLINRHGGVLPPLLASAIQKLTGTGAELVLSGSQWQSLPVLPADGTQVSFPY
                     AGEWLTEDEIRAVLDAVHDAVRSVSYQVAEDARRIRAALTTTGQTLLTRQTRRFRLVVK
                     ESDHPCWLDEDDENLPVVLDAILNRGARFSSVEMYLVSECVEHILSSGLACDMLRIPDE
                     PPRRWFDRGVLREVVREARNEIRSMADSLAKIRK"
     CDS             15989..16414
                     /locus_tag="ctg1_20"
                     /transl_table=11
                     /translation="MQYAKPVTLNVEECDRLSFLPYLFGLDFLYAEASVYALAKKMMPE
                     YEGGFWHFIRLPDGGGYMMPDGDRFHMVNGANWFDRTVSADAAGIILTSLVINRQLWLY
                     HDSGDAGLTHLYRMRDAQLWRHIEFHPECNAIYAALD"
     CDS             16461..16883
                     /locus_tag="ctg1_21"
                     /transl_table=11
                     /translation="MYCTVKEIIRDVLDTDVPDSECVFAVVLTRGDVRYIAQDWNLSDD
                     ELETVMQRLDDAFEYGADVSIVHDVVRELMEEKRASRQVTVPAVMLEKVMALAGSEMKR
                     LYAVGSENGGDGDAFVREEREAMDVVLQALDGEHMS"
     CDS             16880..17071
                     /locus_tag="ctg1_22"
                     /transl_table=11
                     /translation="MNISTETREILRNYRAVINARRREMGQKPLTTAQIVDEICDFVAN
                     QQAVFLGGHYILQGSRNR"
ORIGIN
        1 gtgactgatc ttcaacaaac gtattaccgc caggtaaaga acccgaatcc ggtgtttaca
       61 ccccgtaaag gtgccggaac gctgaagttc tgcgaaaaac tgatggaaaa ggcggtgggc
      121 ttcacctccc gttttgattt cgccattcat gtggcgcatg cccgttcgcg tggcctgcgt
      181 cggcgcatgc caccggtgct gcgtcgacgg gctattgatg cgctgctaca ggggctgtgt
      241 ttccactatg acccgctggc caaccgcgtc cagtgttcca tcaccacact ggccattgag
      301 tgcggactgg cgacagagtc cggtgcagga aaactctcca tcacccgagc cacccgggcc
      361 ctgacgttcc tgtcagagct gggactgatt acctaccaga cggaatatga cccgcttatc
      421 gggtgctaca ttccgaccga tatcacgttc acaccggcgc tgtttgccgc tctcgatatc
      481 tcagaagagg cggtggcttc cgcacgccgc agccgtgtgg aatgggaaaa cagacagcgc
      541 aaaaagcagg ggctggatac cctgggtatg gatgagctga tagcgaaagc ctggcgtttt
      601 gtgcgtgagc gtttccgcag ttaccagaca gagcttaagt cccgtggaat aaaacgtgcc
      661 cgtgcgcgtc gtgatgcgaa cagggaacgt caggatatcg tcaccctggt gaaacggcag
      721 ctgacgcgtg aaatctcgga agggcgcttc tctgccagtc gtgaggcggt aaaacgtgaa
      781 gtggagcgtc gtgtgaagga gcgcatgatt ctgtcacgta accgcaatta cagccggctg
      841 gccaccgctt ccccctgaaa gtgacctcct cagaataatc cggcctgcgc cggaggcttc
      901 cgcacgtctg aagcccgaca gcgcacaaaa aatcagcacc acatacaaaa aacaacctca
      961 tcatccagct tctggtgcat ccggcccccc ctgttttcga tacaaaacac gcctcacaga
     1021 cggggaattt tgcttattca cattaaactg caagggactt ccccataagg ttacaaccgt
     1081 tcatgtcata aagcgccatc cgccagcgtt acagggtgca atgtatcttt taaacacctg
     1141 tttatatctc ctttaaacta cttaattaca ttcatttaaa aagaaaacct attcactgcc
     1201 tgtcctgtgg acagacagat atgcacctcc caccgcaagc ggcgggcccc taccggagcc
     1261 gctttagtta caacactcag acacaaccac cagaaaaacc ccggtcccgc gcagaaccga
     1321 aactacaaag cccctccctc ataactgaaa agcggccccg ccccggcccg aagggccgga
     1381 acagagtcgc ttttaattat gaatgttgta actatactcc atcatcgctg tcagtcttct
     1441 cgctggaagt attgagtaca cgctcgtaag cggccctcac ggcccgctaa cgcggagata
     1501 cgccccgact tcgggtaaac cctcgtcggg accactccga ccgcgcacag aagctttctc
     1561 atggctgaaa acaggtatgg cttagcaggg ccggggatgg gcaaggtgaa atctatcaat
     1621 cagtaccggc tgacgccggg cttcggcggt tttactccgg tatcacatgt aaccacagcg
     1681 tgccgccttc catgccgctg gcgcggcata agcatatgtt ggtggctgtg tctgaaaggt
     1741 tatatactct gcataaaacc tgacaacacg cagattgcca ggcaaatgag cattatgcat
     1801 ccggttatcg cctgcctgtg aaacaatatc accggggcga atatcgatac tctgactcgt
     1861 tatacccatg cgtgtggcat caaaaaacct gcaattgccc tttattgaat gaaaggggga
     1921 gtcaattatg aatagcacca cacattacga aaacgccaat ttcctgcgcg agctggccga
     1981 aagcctgcct cgtatttttc cagaaggcag tacagacaag tctgcactat tgcaacgcct
     2041 cgctaatgaa gaactggcac gggcggaata cgacgaacag atccgagcga aagttgccgc
     2101 tgcccgcgcc gataagcggc cgggaatgag ttccgcgcaa ctgcgccagc aactacaggg
     2161 acgttatcag gaactgcgca atgagttatg aaatagaatg gcgaccaggt gcgattgagg
     2221 atataacggc gttgtttgaa tatctggtcg agaatgcatc tctttgggat gcaaggaacg
     2281 tgacagagcg tctgatcact gcaaccgatc gcctggctga ttaccccagg ctgtatgaaa
     2341 cggatgaacg ctatggtgaa ggggttcgcc gtattagctt acttggacag catgtacttt
     2401 atgaagtgaa tgatgaggcc agtcgtgtca atatcctggc ggttgtaggc cagcgtcaga
     2461 atccccgatt cattctttga gtgtccggct tggaactcca tcttcagaga atcgatcaac
     2521 gttctttagc tccttccact aacagccgac ctatctcaaa caccgcagct gaccgtcccg
     2581 acttcaccgc ttcggctttc tgtccctcaa caaaccagtt attaccgtcc gttcggacca
     2641 actcaaacat ccatgacata tcgtaaacgt gttccgggat cagcgaccct tctccggcca
     2701 gaatacccgc cgttatggag tggttgcccc cgtgcacaaa gccaatacgc cagggcaacc
     2761 acaggtcaac atagtggttg tttttatctt gcttccacgg cttcccctta tgggttccaa
     2821 tgcgtgaaac gttatcgata tagcgtggta ggctccaagg ccacggcagc actatgtcgc
     2881 ttgccagcga caacggataa tcagcgccgt tcatctcaca ctctttcatc ttttcgtaag
     2941 attgtatttg ggtaagtccc ttaaagaaga actcctgcgg ggtcatatcc gggcgggcat
     3001 ctgttccctc ctcagctacc gccagcaaga aatcactctg tactggccgc acgatagcgc
     3061 gaatgagatc tggtagcgcc ttaacgggta gtttctctgc cacagaaagc agatgattga
     3121 agcgtttttt ttcattggct atagttgctt tatctttctt gtttcggttc cagaacatca
     3181 ctgtctgtag ccctccttat cgtgatcagg atgatggttt tcattctaat ggtgtagtag
     3241 tttcacgtca cgcgcacgtg catattcttc gaaagcttcg gcgttagccg gtcaaccagg
     3301 ggtttgaggc ccaaccgtac gagatcgtac gctaagttca ttttttgagc agaagaggtg
     3361 agtaaagaaa acgagggttt tatttactct tcccgtcaat gccagtagcc atgcggtttc
     3421 agggactttc agtgttaata aactcggtaa tcaaatcaac gtaaacctgc ctaacaacgc
     3481 cacgacttta ttgacttaaa atcatatagt tagcttctta gcgtacgttt ccgctccatt
     3541 gggcttcaaa ccccacaccc aatgacatga gaaaagctgg atctgattct caaaatgctg
     3601 ggatacccat cgagatggag aactcagtca atgttccatt ctttctgaaa tatgtgtggg
     3661 gacactgatc tgtcgggagc cggatgcggt agttccgcag gtccggttct gaggaggggc
     3721 ccgtccgggc aaccggcggg tctactcacc tcatccccct acaaccactc ccattcgttt
     3781 aagtattttt aaacctgctt cctgtggtat ctttatagat aagatcctgt ttatctcagg
     3841 atttatatcg agaccttctg tcattgaaaa atcacagtga gacaaatcag aatgtctgaa
     3901 ctctgtatta ttaaactccg aaccagtaaa atcagattta cgaaggtctg tttcctcaaa
     3961 taaacaatca cggaagcgac aggataaaaa aatagatttc tgtaaccgta aactaataaa
     4021 atcaacaaat ctcaaatcac aatttacaag agaaaaagta cagggaaaca taatgtctgc
     4081 tgcatttact ccttgtaata aacaatcttt gaattcacag tcaataagtt taaaaaaatt
     4141 aagttttaaa ttctttattg agcagtttac gaagcgacat ttttcgaact cacaatcgcg
     4201 aaagttaaag ttgtcaagct gtattcgttc aaatatacaa ttgtaataat ttacacctga
     4261 taattcactt tcactgaggt gtcgttttgt gattcttttt tctattatat ccatgtgtca
     4321 gtctcctgtt cccataactt ctttaataaa tgccttttct ggagttgttt cattattgga
     4381 ttgaataaaa tcactcatat cagaataacg atttatacta ttttttgaaa gcatatagaa
     4441 ggggatttta tctcttgtta attcatcaaa aatatgagtt gagaaaaata ccgttttccc
     4501 gtcagcggtg atcttattta tcagttccca taacatcatt ctgtactgaa tatcaatgcc
     4561 tacagttggt tcatccagta aaaataaacg ggcatttttg caaagcgtta gcatcaaaga
     4621 tatgataagc caacgcttct ctccataact taccgtgtaa gtccttttac gtcttatttt
     4681 atcatagcga atgaaaaaat tatcattcca tttatgatta agctctgtcc atgcctgttt
     4741 tttagttaac ttattgaagc agcaaatcaa atcaagaacc tcctcattcc ttagtgtacc
     4801 tgaaagattt atgacttgag gtagacttac taattctcca ccagagaaat ttcgcttgag
     4861 ggtcccttca taattactga ctccgcccct gataaggtta aaaagagtgg tcttcccggc
     4921 tccattttct ccaagcagac ctatcaactc tccctgctca atcttaagcg acagattatt
     4981 gaaaacaggg ggtaaattta ctttatatga aaagctcaga gagttgattt ctaaaagagg
     5041 tatggtcatt gagaactcca gactggctca gttttgaagg ttagtgctga aataatactt
     5101 atgattaaca ttatactata gaaaaatatc gtcatcagag acaactcctg gtctgactgg
     5161 agtattgtag aatagatggc gataggatta acctgattta tccagtaaac gatcccctca
     5221 ttatatttta atgatacaat tcctgatacc atacagacag ttattaatac agaatagata
     5281 gtgctggctg tttggaatgt gactctgaac gatgccatga aagtgagtga aaccatcata
     5341 aatgcattta tgtatatcga ttttaaaata atcattacta tttgataatc tggacttgcc
     5401 tggaatcctg ttagtacgac taaaatgaaa aaaaacacat acaaaataga catgataagt
     5461 gaggctatta attgagaacg aataaataat agtcgaccat ccatattatg cacgaaggta
     5521 gcaataaaac cactttctct tcttccgacc agatacagac agtaattaaa cagaacaaca
     5581 gaaaaagaaa tgtagcctac aaaccatgat atttgttttc cgagccatgc tgtatcacca
     5641 taatgaagtt caatttcatt gaaatgaagg aaaaagaaca acactgtagg tgacataatt
     5701 gtccatatta agctgaaagg ggttctgatt tgttccatca gaaaaattat cgccattttt
     5761 aatgtaacca tttgttatcc ttatgggaat ggtaccatct ttgattctct gactttaata
     5821 ccgtccccgg tatggtaaat tttattatta atgtttattg cacctgagtt attcatatga
     5881 aggaaaaaat cagggcttac tatttttgtg taccagacaa ggctgttact tactctttcc
     5941 ctggcatagt aaacaaaaat attatcagaa atttgttgaa gatagtttaa taaatttgtg
     6001 tctgacgtaa tattttcctc aagcgttaac ttgacatcat cagacagtag taccgtattt
     6061 tcacacaaat ccgtaaacga ctcgtacttg ttgcatgaca taaagtgacg ctggtaacta
     6121 tcaataatgt catcatcagt ataaccgcca ataagaaagt tgtgcaggca tatatacgat
     6181 tgccacaatt ccactacgga tttacaaagt gcttttttca gactattagc ataggataat
     6241 ccggtactgt attttattcg actgattttg ttttttgtgc catacagggt tagtactgcg
     6301 tgtccaggag ctccgggcag ggtgatatcg aaaatcctga tatctccttc tgacctgaga
     6361 gccagtaaaa tctcatctat atgatttatg cctgttacta tttcactgga tatttcagta
     6421 ttggcttttc cctgtaacca gtaaagaagg agggactgtc tctccataaa ttcacacaag
     6481 gaaccttcta tggcatcgtt caaactacca tgaaagctac atccgcatgt atctctgtca
     6541 ggataaaatt tcagatcatc tgcagcggtt atattgtcga gtgcaattat gactgcaggt
     6601 atttcttgtt gttcaaggct aaacagatta aaggctctga ccgttttaaa tttatgggtt
     6661 atgatttcat cgcgggtcag tgatgagatc tgaaaaaatg cttcggtaaa agcctttgca
     6721 gcagatggag gcatcatctc atataatgtt ttctgaccac cggtgactat ctcattaaaa
     6781 aaatgacggc gttcaaaata ttcacctatt gccccctgaa ttgacttcag agtttcaccg
     6841 gccgcgctgg ctggtgtaat acgctcatag tcccatatct gagaaaacgt tggcatattt
     6901 ctgttcagtt ttggactcat ggccattgtg gccggccatg cggacataag gttactgtag
     6961 acatttatca tcgtttacat ctccaaaaaa ctgaacgatc agtggcgcta cagtcctctg
     7021 atccagattc attgtttttg ctacgtatga atcggtatat cccgcccata cccggttttt
     7081 cagtcctatt tgatctgcaa ccaatactgc gttctgatac atcgaacctg tttccattaa
     7141 ggccatccgg tatcctctgt agcgatattt gaacaaagct ttttcaaaaa taatgcaata
     7201 gacgagagca aaatggggtt taccaagacg ttccgaatcc ccaccggaca ggcttcggta
     7261 gagtgactga gtattacatg tagcaacagg ttccagtgcc tgacttagcg gcaggtagtg
     7321 ataaacatta gttcctgcct gccagttttc tgtattttca gataatctgc ataaaaaaac
     7381 ttcaatcggg tacaatgccc ccccagaagg ataaggtctt cttacagagc caggatcagg
     7441 tgagctgaat gcattgacta ataacttttc aatagtacga atggaaagtt tatttttgtc
     7501 gcaaaagttt attcctgatg ggagcctttc acgactaaaa ttatgtgatg aggatatgtt
     7561 tattacggag ctgaaacctg gcctgaagag aacttcttta ttttcaaatt tctccagatg
     7621 ggcaagaggt accgcggaca cgaaagttcg ttcagcaaat tcggggaggg aagcaaagtt
     7681 acctctgaca tgaaaatctt taacaatggc cagaacttca ggatctgtgt aatgcgttac
     7741 ttccactaaa gagagttcgt gttttgacat gttatctctc cagacagctg caagcctgcc
     7801 agtgaattac cggctcttta cataaaatac aggtgattaa atcagcgcta acagatgaca
     7861 taaagttatc gacatgactt ttaaccagtg aagtacctgt caactcctga agtcgccgtt
     7921 ttattaaatg atagctgaat cctctttctg attcgcctaa agccaatgct ggtagtgtca
     7981 tttggtattt tttcagtaac tgaagtaagt ttgcccagga catttcgtta cgtctgaagc
     8041 ttttttcttc cctgctcagc catctctcta tatgacaaaa atggcaggga gtaccaagat
     8101 caggtgaata tactccatct atcctgaatg actcctttag gtagtagctt tggatgaagg
     8161 caacaccagg gttactttca aattttgaat agattctttt tacaatgtct gaatgatagt
     8221 tttcgagatg taaccagatt agtgttgaat cgctcacatt aatattatta tcttttatat
     8281 caatgatatg agaaacaaaa acaccatcag atttccattg ttcccgggca ttactgaaaa
     8341 gatgtggaac atcgcttatt atgactgagt ttacccagag aggtgatgtt ttcgttttat
     8401 ttatcacgcc tgtggtaata agaaactctt tgcccttgtc tttatcaata agcgattcgt
     8461 ccagtagttt atcaaggagg tattcagaaa taataccctg tttggatcgt aggctttcga
     8521 gtactttttt cattccctca tgtgtaatgt ctactgaaga aatgtaggta ataagcaggg
     8581 tctttgtatt tctggaaatt atctcaaacg gcagaatatt gatcatatct tttccttttt
     8641 taatatcagg gagcaccatg ctccctgaac ggttaattca acgtatcaga tatgtgaacc
     8701 acttccgccg ctgccaccgt ttccaccact acaaccgttg ctgcaaccac cacaaccgcc
     8761 accttgacca ccgcagctac cgccgccacc accaccaatg ccaacaccta atggagactg
     8821 gcgtgataat ttaagagcat caacggacaa aactacacca aattcactcg cttttaattc
     8881 cataaggact ccttttttaa gggaaattaa tgcttatgac atctgaatag tatgttggcc
     8941 aacactagtt acttgccgta attaactata ttttgcaatg ataatttgaa ctaaatttgt
     9001 acgcctgtta aatatttaat aataatatca gttggttatg tttatgctgt tattgttttt
     9061 ttacaaaaat taatattgtg tttatatttt gctttcagtt gctgtcagga tgtcacacta
     9121 cccctttaag cccccactgg tctggcaggg ccgggggtgg gtaaggtgaa acctgtcaat
     9181 cagtaccggc ttacgccggt atcatatgca acaactgagt gccgccttcc atatcatatc
     9241 atttgcccgt ttcccgccgt gcagatccgg tttccggctg aagtggatcc agacctgatt
     9301 tgttgctgag tatcggtaaa agagcggctt ataatctatt ctgaaacatg gcaagtgaat
     9361 ctgggctgta taattccggc aagtgtcatc tgtatttaaa ggtcgtgtga gtatgaaatt
     9421 tatggaatgt gctgtccggg atgtgattta tgggaccaat gtccgtattg tcaaaccggt
     9481 caacatttat gaatgtgaac tcagggacaa tgtgtttgtc ggccccttcg ttgagataca
     9541 gaaaggctgt gtcattggta gtggaagccg gatacagtcg cacacgttta tttgtgagaa
     9601 cgtaacactg ggggagaact gcttcattgg tcataacgtg acgttcgcca acgatctgtt
     9661 tcgttcagga gcaccagatc cgtcaccgga taactggatc agcattaccc tgggggattc
     9721 ggttactgtt ggcagtggag ccattattct gtctccgtat atatgcagcg gagctgttat
     9781 tggtgcgggg gcagttgtag taaaaccgat tgagaacaaa ggcatttatg caggaaaccc
     9841 ggcaagactg atcagaatat tatgaaaaag aaaagggccg ttactggccc tttttatcag
     9901 aggtaggtct gtgaatacgg caggtgtaca gaaatcgact gccggggatc gatttccagg
     9961 gccgcccggt attctgcgtc agtgatatca ccttttttca gtaaataacc gagagcatcg
    10021 tttcccagcc ctgacagtat gcgtattctg gcgatccgga ctggcaaata acccatcaaa
    10081 aacgttattg ccagacattg cgaactcacc aattttgatt attggagcca ctttttcata
    10141 agttccgtga aattatttca taataacgac cctgtttatt ttatgtaatg actggcaata
    10201 aaataacttg attaagttcc ctttatccag cctgatagtg gataaaggaa actcaatcat
    10261 aatttaatta gtttattaac ttcatcgcat tcttttttgt ctcctcatca cttttttgct
    10321 ccgattgtga agaggactga atgattgttg aagaatttaa atcggccatc tcttttggaa
    10381 atagcgatct caatatattc acgatatctg aaaatgtggt ttctttcgtc agcagttcac
    10441 ataaaaggaa aggggccctg ggatcttgtc tgtataaggc cagacctgcc gtcagtgcag
    10501 cccggttaag gcggctgcgt tccccttgcg ggatactgtc cagtgtatca caaacaattt
    10561 tatctgtttg atttacatct ggatttagct taaaggcaat ggttctgcgc ttgtccatca
    10621 ttaattacct atgagataca taccgttaac taaatcatat tgagagttat tggttttaaa
    10681 aaaacgttca tcacgaatct gtgtgtgttt ttttactgca tcgcatatta attctgcgcc
    10741 accacctata accataacat gagtataacc agaaaattca ttgagtgtat ttaatacacg
    10801 ttgctcaagt ttacgaagtg cttcattcat tgcttcggtg actattgata ttttgttctc
    10861 atcattaatt cgttgcttca gatagttatt atcttttctg tgaataatta tatcatcagc
    10921 aagatagcta cttccttttg ttctcgcaag agaaagggca tcttttactg cagatgtgac
    10981 cagagataca ccaagagatg agtctccgta tattttactg atccccgata atttccccat
    11041 tacctgagaa atatctaatg tggtgccccc gagatctata attaataaag aatctaactc
    11101 atccagttct tgtagaactt cataacctgc cggtatagat tcaggcatga cttttacatc
    11161 ttttattgtg aatgtatccc caccatttaa tgtaattttt ttccggaagt ttgctttctt
    11221 acgctcaata ttttccgtat tgggttggtt attcctgtcg taatactctg tcagaggaag
    11281 tgtgcaaaca atatccactt cgcttaccgg cagaccactg gtcagtaagg cgtggtgcac
    11341 cgcaacgaca ttaacgtcgc tgtattgcca tgcgatattg gttgtgacta cagcatccgg
    11401 gctgattgga tcaaatgaat actgttcgcc gttcagtgtg tagttaaaga cctttttatc
    11461 accaaaagaa actgcccact cgcgtttgaa gctgttcggg ctaatgtgct gtttaattgt
    11521 tccgtcgctt tcctgccact gtagtttgat gtttgttgaa ccgtcatcaa tgaataccaa
    11581 catttataaa actccttatg gtgttttttt ggtgtttgtt tgggtgtgtt ttgggcttta
    11641 aatgggttta tttgtcaagt ttaccccatt ttaactatca atcaatgatt atttgtcttg
    11701 ttttggtgtt ttgttgggct tggtatgggt tgtttttggg ttttgtttgg cggataacaa
    11761 aagatgtcgc cgggctcctc tttttactgc gccggctgac gcggcgcggc aggaacgctg
    11821 cctgtggtca gtgtcccgcg tccggccggg cacgggacgg gcgcttttac cgctcccggc
    11881 tggcgtcggt gacagtgtac gccagcccgt cgcccttttc tgatgagcgc ccttcaagcc
    11941 gctttcgcgg catagccttg ccgtcaaaaa gacgacggct gcggtattcc acggtcggcc
    12001 tgacccgtta ccgggcgcgg tgaacagccc acaggcagcg gggaacgggc gccacagggg
    12061 cgccctcccg atgctcctgt gaggataatt cccatgccaa actggtgctc gaatcgtatg
    12121 tatttttctg gtgaaccggc acagatcgct gagattaaac gactggccag cggtgcagtc
    12181 acaccgcttt atcgccgcgc cacaaatgaa ggtattcagc tgtttctggc cggaagtgcc
    12241 ggacttctgc agatcactga aaatatccgc tctgagcagt gccccggagt gacggctgcc
    12301 ggacgtggtg ctgtatcacc ggaaaatatc gcgttcaccc gctggctgac acacctgcag
    12361 aacggtgtac tgctggatga gcaaaactgc ctgatgctgc atgaactctg gctgcagagc
    12421 ggtactggac agcgtcgctg ggaagagtta ccggatgatg tcagggaaac tatcactgtg
    12481 catttcaccg caaaaagagg tgactggtgt gacatctggg gtaacgagga tgtatcggtg
    12541 tggtggaacc gtctgtgtga caacgtactg ccggaaaaaa ccatgccgtt tgacctgctg
    12601 acggttttgc cgacccgcct ggatattgaa gtgaatggct ttaacggcgg tgttctgaac
    12661 ggtgttcctt ctgcatatca ctggtataca gaacggtatg gcgtgaagtg gccttgtggg
    12721 tatgacctga atatcagcag tcagggggaa aacttcattc aggtagattt cgacacgccg
    12781 tggtgtcagc cggaaagcga cgttgttgca gaattaagcc gccgtttcgg ctgcacgctg
    12841 gagcactggt acgccgaaca gggctgcaat ttctgtggct ggcagttgta tgagcgcgga
    12901 gagcttgttg atgtgctgtg gggggaactg gaatggtctt ccccgacaga tgacgatgag
    12961 ctgccggaag tcaccggacc tgcgtggata gtcgacaatg tgacgcatta tggcggatga
    13021 agtatgacgg agacgggcgg gcaaccgccc gtttcttttc cgacaaagga tgtcgccgtg
    13081 ctcctctttt tactgcgccg gctgacgcgg cgcggcataa acgctgcctg tggtcagtgt
    13141 cccgcgtccg gcgggcacgg ggcgggcgct tttaccgctc ccggctggcg tcggtgacag
    13201 tgtacgccag cccgtcgccc ttttctgatg aacgcccttc aagccgcttt cgcggcataa
    13261 ccttgccgtc aaaaagacga cggctgcggt attccacggt cggcctgacc cgttaccgga
    13321 cgcggtgaac agcccacagg cagcggggaa cgggcaccac aggggtgccc tcccggtgtc
    13381 ctctgtaaga gaaggagtgc tgttatgtcc cgttttatcc tgggtgactg cgtgcgtgtt
    13441 atggccacgt ttccgggcaa tgctgtcgat ttcatcctca ccgacccgcc gtatctcgtc
    13501 ggtttccgtg accgttccgg gcgcaccatc gccggcgata aaaccgatga atggctgcaa
    13561 ccggcctgta atgaaatgta ccgcgtgctg aaaaaagatg cgctgatggt cagcttctac
    13621 ggctggaacc gcgtcgatcg ctttatggcc gcctggaaaa atgcgggatt cagcgtggtt
    13681 ggccacctgg tgtttaccaa aacctacaca tcgaaggccg catatgtggg ctatcgccac
    13741 gaatgcgcct acatcctggc aaaaggacgt ccggcgctgc ctcagaagcc attgcccgac
    13801 gtgctgggct ggaaatattc aggcaatcgt catcacccga ctgaaaagcc cgttaccagc
    13861 ctgcaaccgc tcattgagag cttcacacac ccgaacgcga ttgtgctgga cccgtttgca
    13921 ggcagcggct caacctgtgt ggccgccctc cagtccggac gccggtatat cggtgtcgag
    13981 ctgcttgaac agtatcaccg tgccggacag caacgactgg ccgccgtgca acgggccatg
    14041 cagcaggggg ccgcgaatga taactggttt gaaccggagg ctgcgtaaat gaactatgcc
    14101 ggacacgaaa aacttcgcgc cgacgtggcg gaggtggcca acaccatgtg tgaccttcgg
    14161 gccaggctga acgatatgga gcatcgctgt cgctttgatt ccgatgtgct tgttgaacgc
    14221 ctgacacgcc agacgctgta tcgcgccaat cgcctgttca tggaagcgta taccgaaatt
    14281 ctggaactgg attcctgctt caaagattga gaaggagacg agaatgtacg gaacatgcga
    14341 aacgctctgc cgggcgctgg cagcaaagta tccgggagat acgccgctga tgctggttat
    14401 ctggtccccg gaagaaattc aggccctcgc tgacggaatg gatatttccc tgtccgatca
    14461 tgaaatcagg actgtcctgg cgcgcctgga ggacatcccg gaagaccagc ggactgaatc
    14521 cggtatttct tccggtgcgg cgatggagat catcaataac gtgagagaaa accgccaggt
    14581 gaccgtccct gctgaactgc tggcgtccct gattcagacc gctgaacagg cattgtggaa
    14641 acgtgaatgg gccgcccggg atcatggcct cgccgtcccg gaatgcgtca cccgccgtca
    14701 ggcggtggtt aatcaggtcc gcatcctgct gaaaaacaac acacacgaaa acgactgatg
    14761 ttatcgccgc ctccgggcgg cgatacaggg agttcatgaa ttatgaatga aacgctgaat
    14821 gcactgattt atcgccacgc cagcaacctg ttgctggcgc agggctggcc ggaagagacg
    14881 gatgttgacc agcgtaaccc gaagtatccg ggctggatca gcatttacgt gcggctggat
    14941 gcgccccggc tggcgacgtt acttatcaac cgtcacggcg gcgtactgcc gccgctcctg
    15001 gcctctgcca ttcagaaact gaccggaacc ggagcggaac ttgttctgtc cggcagtcag
    15061 tggcagtcgc tgccggtact tccggcagac ggaacgcagg tgtctttccc gtatgccgga
    15121 gaatggctga ccgaagacga aatcagggca gttcttgatg cggtgcacga tgcggtacgc
    15181 agtgtcagtt accaggtggc agaagatgcg cggcgtatcc gtgcggcgct gaccaccacc
    15241 ggtcagacgt tgctgacccg ccagacgcgc cgctttcgcc tggtggtgaa ggaaagcgat
    15301 cacccctgct ggctcgatga agacgacgaa aacctgcccg tggtactcga tgccatcctg
    15361 aaccggggcg ctcgtttttc gtcggtggaa atgtatctgg tcagtgagtg tgtggagcat
    15421 atcctgtcca gtgggctggc ctgcgatatg ctgcgtatac cggatgaacc gccccgccgc
    15481 tggtttgacc gtggtgttct gcgggaggtg gtccgggaag cccggaacga aatccgcagc
    15541 atggcggatt cactggcgaa aatccggaaa tgatgacgct ggcggggaaa aatctccgcc
    15601 ttttccagcc ggtccccgga aagagcaaaa ggatgtcgcc gcaggctccg ctttacccgg
    15661 ccatgcgggg catggccttg tgggttttca gttatgtggc ctcagcgccg tgtgcgggct
    15721 gtgccgtgcc tccatcgtag ccgggcttct gcgggcgggt tgcaaggtaa ggtgaaccgc
    15781 tgcggtcacc cggtccctcc ttcccgtctg ccgtgatttt ccggtcgttc acccgctcag
    15841 atttcgcggt ctcacccttc aactcccgtc agccgtgcgc gtcaggctgc ggcttccctt
    15901 gcgcccttgc aaccctgcag gcccggcaaa gatggaggca cggcaccgcc cggtgtcgcg
    15961 gaatatgtga acaacggagg aaaacatcat gcaatatgcg aaacctgtca ctctgaacgt
    16021 tgaagagtgc gaccgtctgt cttttctgcc ttacctgttt ggcctggatt ttctgtatgc
    16081 cgaagcgtct gtatacgcgc tggcgaaaaa aatgatgccg gaatatgaag gcggattctg
    16141 gcacttcatc cgcctgccgg acggtggcgg ttacatgatg ccggatggcg accgtttcca
    16201 catggtgaac ggtgcaaact ggtttgaccg tacggtcagc gccgatgccg caggcatcat
    16261 tctgacttcc cttgtgatta accgccagtt gtggctgtac cacgacagcg gggatgcagg
    16321 actgacccat ctttaccgga tgcgcgatgc gcagttgtgg cgtcacatcg aatttcaccc
    16381 cgaatgcaac gcgatttacg cggcactgga ctgattaacg gacggggcgg caatgccgcc
    16441 cctgtaaagg agacgagaac gtgtactgta ctgttaaaga aatcatccgc gatgtactgg
    16501 atacagacgt gccggacagt gaatgcgttt ttgccgtggt gctgacccgt ggggatgtgc
    16561 gctacatagc ccaggactgg aacctgtcag acgatgagct ggaaaccgtc atgcagcggc
    16621 tggacgatgc ctttgaatat ggtgcggatg tcagcattgt tcacgacgtt gttcgtgagc
    16681 tgatggaaga aaagcgagcc agccgtcagg tgacagttcc ggcggtgatg ctggaaaaag
    16741 tgatggcgct ggcaggcagt gaaatgaagc gcctgtatgc cgtcgggagt gagaacgggg
    16801 gcgacggtga cgcattcgtc agggaagaac gcgaagcaat ggacgttgtg ttacaggcgc
    16861 tggacgggga gcacatgtca tgaatatcag cacagaaacc cgcgaaattc tgcgtaatta
    16921 cagggccgtg attaatgcgc ggcgtcgtga aatggggcag aaaccgctca ccaccgcgca
    16981 gattgttgat gaaatctgcg attttgtggc gaatcagcag gcggttttcc tgggcggtca
    17041 ctacatctta cagggcagca gaaacaggtg atacaggggc aggcggtgga ggccgcctgt
    17101 cagcccgcgc gaacccccct ggcaggctgg cgcctgccgg aagggaagcg ggccacgctg
    17161 gcgcgtcgcc cgttaccctt cccgtctgtg atgtgtctga ctcaggagtg tttctttctt
    17221 atgttatgga actgttcctg atgttgttgt tgttgttgtt gttgttcctt tatctgctgc
    17281 tctgattctg actactgcag tgttgttctg tctgccggac gcaccttcgg ctcccggctg
    17341 cctggcggca tccggtcgtc aggcccgact ccgacaggca gctgctggcg cacccgccag
    17401 tctccgccga acccgctggc gcggtttcgg gctgtcgcta cggtccgatg cgtgaaaacc
    17461 cccggcttgc agcgaccgtt ccggtcgcgc cgcctctgtc gcgccgtggc ctgcgctccc
    17521 ggcatcccgg caaaaggccg ccggaatgta aggcgcaacg ccgtttcgca aaccgcgctt
    17581 cacgtcgttg ctgcgggtcc ctgctcattg cctgccgggt gccacacacc cgtatgagtc
    17641 cctgtcgccg ggggcataga cagccacaac ctgccgcact gactgtccag ggtaaatgaa
    17701 cagcccacaa aattttttac ccaaaaaccg gtaaaaaatt ttgcgttctg cccaggacag
    17761 gtgcgtcagg
//
