LOCUS       NZ_CP047713.1          17770 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP047713.1 Escherichia coli strain Eco-15 plasmid pEco15-3,
            complete sequence.
ACCESSION   NZ_CP047713
VERSION     NZ_CP047713.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-06-07 20:39:15
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17770
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..858
                     /locus_tag="ctg1_1"
                     /transl_table=11
                     /translation="MTDLHQTYYRQVKNPNPVFTPRKGAETLKFCEKLMEKAVGFTSRF
                     DFAIHVAHARSRGLRRRMPPVLRRRAIDALLQGLCFHYDPLANRVQCSITTLAIECGLA
                     TESGAGKLSITRATRALTFLSELGLITYQTEYDPLIGCYIPTDITFTPALFAALDVSEV
                     AVASARRSRVEWENRQRKKQGLDALGMDELIAKAWRFVRERFRSYQTELKSRGIKRARA
                     RRDAGRERQDIVTLVKRQLTREISEGRFTASREAVKREVERRVKERMILSRNRNYSRLA
                     TASP"
     protocluster    1..17770
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5780:7770]"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5781..7770
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
     cand_cluster    1..17770
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /kind="single"
                     /product="LAP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17770
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="LAP"
                     /region_number="1"
                     /rules="((((goadsporin_like or PF00881 or TIGR03605) and
                     (YcaO or TIGR03604)) or TIGR03882 or TIGR03603 or
                     TIGR03602) and not cyanobactin_synth)"
                     /tool="antismash"
     CDS             1928..2191
                     /locus_tag="ctg1_2"
                     /transl_table=11
                     /translation="MNSTTHYENANFLRELAESLPRIFPEGSTDKSALLQRLANEELAR
                     AEYDEQIRAKVAAARADKRPGMSSAQLRQQLQGRYQELRNEL"
     CDS             2181..2480
                     /locus_tag="ctg1_3"
                     /transl_table=11
                     /translation="MSYEIEWRPGAIEDITALFEYLVENASLWDARNVTERLITATDRL
                     ADYPRLYETDERYGEGVRRISLLGQHVLYEVNDEASRVNILAVVGQRQNPRFIL"
     CDS             complement(2516..3181)
                     /locus_tag="ctg1_4"
                     /transl_table=11
                     /translation="MMFWNRNKKDKATIANEKKRFNHLLSVAEKLPVKALPDLIRAIVR
                     PVQSDFLLAVAEEGTDARPDMTPQEFFFKGLTQIQSYEKMKECEMNGADYPLSLASDIV
                     LPWPWSLPRYIDNVSRIGTHKGKPWKQDKNNHYVDLWLPWRIGFVHGGNHSITAGILAG
                     EGSLIPEHVYDMSWMFELVRTDGNNWFVEGQKAEAVKSGRSAAVFEIGRLLVEGAKER"
     CDS             complement(3751..4314)
                     /locus_tag="ctg1_5"
                     /transl_table=11
                     /translation="MDIIEKRITKRHLSESELSGVNYYNCIFERIQLDNFNFRDCEFEK
                     CRFVNCSIKNLKLNFFKLIDCEFKDCLLQGVNAADIMFPCTFSLVNCDLRFVDFISLRL
                     QKSIFLSCRFRDCLFEETDLRKSDFTGSEFNNTEFRHSDLSHCDFSMTEGLDINPEINR
                     ILSIKIPQEAGLKILKRMGVVVGG"
     CDS             complement(4318..5049)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 95.1; E-value:
                     9.3e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_6"
                     /transl_table=11
                     /translation="MTIPLLEINSLSFSYKVNLPPVFNNLSLKIEQGELIGLLGENGAG
                     KTTLFNLIRGGVSNYEGTLKRNFSGGELVSLPQVINLSGTLRNEEVLDLICCFNKLTKK
                     QAWTELNHKWNDNFFIRYDKIRRKRTYTVSYGEKRWLIISLMLTLCKNARLFLLDEPTV
                     GIDIQYRMMLWELINKITADGKTVFFSTHIFDELTRDKIPFYMLSKNSINRYSDMSDFI
                     QSNNETTPEKAFIKEVMGTGD"
     CDS             complement(5046..5771)
                     /locus_tag="ctg1_7"
                     /transl_table=11
                     /translation="MVTLKMAIIFLMEQIRTPFSLIWTIMSPTVLFFFLHFNEIELHYG
                     DTAWLGKQISWFVGYISFSVVLFNYCLYLVGRRESGFIATFVHNMDGRLLFIRSQLIAS
                     LIMSILYVFFFILVVLTGFQASPDYQIVMIILKSIYINAFMMVSLTFMASFRVTFQTAS
                     TIYSVLITVCMVSGIVSLKYNEGIVYWINQVNPIAIYSTILQSDQELSLMTIFFYSIML
                     IISIISALTFKTEPVWSSQ"
     CDS             complement(5781..6971)
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_8"
                     /sec_met_domain="YcaO (E-value: 5.2e-17, bitscore: 54.9,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINVYSNLMSAWPATMAMSPKLNRNMPTFSQIWDYERITPASAAG
                     ETLKSIQGAIGEYFERRHFFNEIVTGGQKTLYEMMPPSAAKAFTEAFFQISSLTRDEII
                     THKFKTVRAFNLFSLEQQEIPAVIIALDNITAADDLKFYPDRDTCGCSFHGSLNDAIEG
                     SLCEFMERQSLLLYWLQGKANTEISSEIVTGINHIDEILLALRSEGDIRIFDITLPGVP
                     GHAVLTLYGTKNKISRIKYSTGLSYANSLKKALCKSVVELWQSYICLHNFLIGGYTDDD
                     IIDSYQRHFMSCNKYESFTDLCENTVLLSDDVKLTLEENITSDTNLLNYLQQISDNIFV
                     YYARERVSNSLVWYTKIVSPDFFLHMNNSGAININNKIYHTGDGIKVRESKMVPFP"
     CDS             complement(6952..7770)
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     PF00881"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_9"
                     /sec_met_domain="PF00881 (E-value: 8.7e-10, bitscore: 31.3,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKHELSLVEVTHYTDPEVLAIVKDFHVRGNFASLPEFAERTFVS
                     AVPLAHLEKFENKEVLFRPGFSSVINISSSHNFSRERLPSGINFCDKNKLSIRTIEKLL
                     VNAFSSPDPGSVRRPYPSGGALYPIEVFLCRLSENTENWQAGTNVYHYLPLSQALEPVA
                     TCNTQSLYRSLSGGDSERLGKPHFALVYCIIFEKALFKYRYRGYRMALMETGSMYQNAV
                     LVADQIGLKNRVWAGYTDSYVAKTMNLDQRTVAPLIVQFFGDVNDDKCLQ"
     CDS             complement(7772..8626)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04424"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_10"
                     /sec_met_domain="TIGR04424 (E-value: 2.8e-88, bitscore:
                     288.5, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINILPFEIISRNTKTLLITYISSVDITHEGMKKVLESLRSKQGI
                     ISKYLLDKLLDESLIDKDKGKEFLITTGVINKTKTSPLWVNSVIISDVPHLFSNAREQW
                     KSDGVFVSHIIDIKDNNINVSDSTLIWLHLENYHSDIVKRIYSKFESNPGVAFIQSYYL
                     KESFRIDGVYSPDLGTPCHFCHIERWLSREEKSFRRNEMSWANLLQLLKKYQMTLPALA
                     LGESERGFSYHLIKRRLQELTGTSLVKSHVDNFMSSVSADLITCILCKEPVIHWQACSC
                     LER"
     CDS             complement(8686..8895)
                     /locus_tag="ctg1_11"
                     /transl_table=11
                     /translation="MELKASEFGVVLSVDALKLSRQSPLGVGIGGGGGGGGGGSCGGQG
                     GGCGGCSNGCSGGNGGSGGSGSHI"
     CDS             9425..9877
                     /locus_tag="ctg1_12"
                     /transl_table=11
                     /translation="MKFMECAVRDVIYGTNVRIVKPVNIYECELRDNVFVGPFVEIQKG
                     CVIGSGSRIQSHTFICENVTLGENCFIGHNVTFANDLFRSGAPDPSPDNWISITLGDSV
                     TVGSGAIILSPYICSGAVIGAGAVVVKPIENKGIYAGNPARLIRIL"
     CDS             complement(10280..10633)
                     /locus_tag="ctg1_13"
                     /transl_table=11
                     /translation="MMDKRRTIAFKLNPDVNQTDKIVCDTLDSIPQGERSRLNRAALTA
                     GLALYRQDPRAPFLLCELLTKETTFSDIVNILRSLFPKEMADLNSSTIIQSSSQSEQKS
                     DEETKKNAMKLIN"
     CDS             complement(10633..11595)
                     /locus_tag="ctg1_14"
                     /transl_table=11
                     /translation="MLVFIDDGSTNIKLQWQESDGTIKQHISPNSFKREWAVSFGDKKV
                     FNYTLNGEQYSFDPISPDAVVTTNIAWQYSDVNVVAVHHALLTSGLPVSEVDIVCTLPL
                     TEYYDRNNQPNTENIERKKANFRKKITLNGGDTFTIKDVKVMPESIPAGYEVLQELDEL
                     DSLLIIDLGGTTLDISQVMGKLSGISKIYGDSSLGVSLVTSAVKDALSLARTKGSSYLA
                     DDIIIHRKDNNYLKQRINDENKISIVTEAMNEALRKLEQRVLNTLNEFSGYTHVMVIGG
                     GAELICDAVKKHTQIRDERFFKTNNSQYDLVNGMYLIGN"
     CDS             12107..13033
                     /locus_tag="ctg1_15"
                     /transl_table=11
                     /translation="MPNWCSNRMYFSGEPAQIAEIKRLASGAVTPLYRRATNEGIQLFL
                     AGSAGLLQTTEDVRFEPCPGLTAAGRGVVSTENIAFTRWLTHLQNGVLLDEQNCLMLHE
                     LWLQSGTGQRRWEGLPDDVRDTITALFTAKRGDWCGFWSNEDVSVWWNRLCDNVLPEKT
                     MPFDLLTVLPTRLDVEVNGFNGGVLNGVPSAYHWYTERYGVKWPVGYEVNISSQGDNFI
                     QVDFDTPWCQPESDVVAELSRRFGCTLEHWYAEQGCNFCGWQLYERGELVDVLWGELEC
                     SSPTDDDELPEVTGPAWIVDNVTHYGG"
     CDS             13418..14101
                     /locus_tag="ctg1_16"
                     /transl_table=11
                     /translation="MSRFILGDCVRVMATFPGNAVDFILTDPPYLVGFRDRSGRTIAGD
                     KTDEWLQPACNEMYRVLKKDALMVSFYGWNRVDRFMAAWKNAGFSVVGHLVFTKTYTSK
                     AAYVGYRHECAYILAKGRPALPQKPLPDVLGWKYSGNRHHPTEKPVTSLQPLIESFTHP
                     NAIVLDPFAGSGSTCVAALQSGRRYIGVELLEQYHRAGQQRLAAVQRAMQQGAANDNWF
                     EPEAA"
     CDS             14102..14323
                     /locus_tag="ctg1_17"
                     /transl_table=11
                     /translation="MNYAGHEKLRADVAEVANTMCDLRARLNDMEHRCRFDSDVLVERL
                     TRQTLYRANRLFMEAYTEILELDSCFKD"
     CDS             14337..14771
                     /locus_tag="ctg1_18"
                     /transl_table=11
                     /translation="MYGTCETLCRELAAKYPGDTPLMLVIWSPEEIQALADGMDISLSD
                     HEIRTVLARLEDIPEDQRTESGISSGAAMEIINNVRENRQVTVPAELLASLIQTAEQAL
                     WKREWAARDHGLAVPECVTRRQAVVNQVRILLKNNTHEND"
     CDS             14816..15586
                     /locus_tag="ctg1_19"
                     /transl_table=11
                     /translation="MNETLNALIYRHASNLLLAQGWPEETDVDQRNPKYPGWISIYVRL
                     DAPRLATLLINRHGGVLPPLLASAIQKLTGTGAELVLSGSQWQSLPVLPADGTQVSFPY
                     AGEWLAEDEIRAVLGAVRDAVCSVSYQVAEDARRIRAALTTTGQTLLTRQTRRFRLVVK
                     ESDHPCWLDEDDENLPVVLDAILNRGARFSSVEMYLVSECVEHILSSGLACDMLRIPDE
                     PPRRWFDRGVLREVVREARNEIRSMADSLAKIRK"
     CDS             15997..16422
                     /locus_tag="ctg1_20"
                     /transl_table=11
                     /translation="MQYAKPVTLNVEECDRLSFLPYLFGLDFLYAEASVYALAKKMMPE
                     YEGGFWHFIRLPDGGGYMMPDGDRFHMVNGANWFDRTVSADAAGIILTSLVINRQLWLY
                     HDSGDAGLTHLYRMRDAQLWRHIEFHPECNAIYAALD"
     CDS             16469..16891
                     /locus_tag="ctg1_21"
                     /transl_table=11
                     /translation="MYCTVKEIIRDVLDTDVPDSECVFAVVLTRGDVRYIAQDWNLSDD
                     ELETVMQRLDDAFEYGADVSIVHDVVRELMEEKRASRQVTVPAVMLEKVMALAGSEMKR
                     LYAVGSENGGDGDAFVREEREAMDVVLQALDGEHMS"
     CDS             16888..17079
                     /locus_tag="ctg1_22"
                     /transl_table=11
                     /translation="MNISTETREILRNYRAVINARRREMGQKPLTTAQIVDEICDFVAN
                     QQAVFLGGHYILQGSRNR"
ORIGIN
        1 gtgactgatc ttcaccaaac gtattaccgc caggtaaaga acccgaatcc ggtgtttaca
       61 ccccgtaaag gtgccgaaac gctgaagttc tgcgaaaaac tgatggaaaa ggcggtgggc
      121 ttcacctccc gttttgactt cgccattcat gtggcgcatg cccgttcgcg tggtctgcgt
      181 cgacgcatgc caccggtgct gcgtcgacgg gcaattgatg cgctgctgca ggggctgtgt
      241 ttccactatg acccgctggc caaccgcgtc cagtgctcca tcaccacact ggccattgag
      301 tgcggactgg cgacagagtc cggtgcagga aaactctcca tcacccgtgc cacccgggcc
      361 ctgacgttcc tgtcagagct gggactgatt acctaccaga cggaatatga cccgcttatc
      421 gggtgctaca ttccgaccga catcacgttc acaccggcac tgtttgccgc tctcgatgtg
      481 tctgaggtgg cggtggcttc cgcacgccgc agtcgtgtgg aatgggaaaa cagacagcgc
      541 aagaagcagg gactggatgc actgggtatg gatgaactga tagcgaaagc ctggcgtttt
      601 gtgcgtgagc gtttccgcag ttaccagaca gagcttaagt cccggggaat aaagcgtgcc
      661 cgtgcgcgtc gtgatgcggg cagggaacgt caggatatcg tcaccctggt gaaacgacag
      721 ctgacgcgtg aaatctcgga agggcgcttt actgccagtc gtgaggcggt aaaacgcgaa
      781 gtggagcgtc gtgtgaagga gcgcatgatt ctgtcacgta accgcaatta cagccggctg
      841 gccaccgctt ccccctgaaa gtgacctcct cagaataatc cggcctgcgc cggaggaatc
      901 cgcacgtctg aagcccgcca gtacagaaaa aaacagcacc acatacaaaa aacaacctca
      961 tcatccactt tcagatgcat ccggttctct ctgtttttga tacaaaacac gcctcacaga
     1021 cggggaattt tgcttatcca cattaaactg caagggactt ccccataagg ttacaaccgt
     1081 tcatgtcata aagcgccatc cgccagcgtt acaaggtgca atgtatcttt taaacacctg
     1141 tttatatctc ctttaaacta cttaattaca ttcatttaaa aagaaaacct attcactgcc
     1201 tgtcctgtgg acagacagat atgcacctcc caccgcaagc ggcgggcccc taccggagcc
     1261 gctttagtta caacactcag acacaaccac cagaaaaacc ccggtcccgc gcagaaccga
     1321 aaccacaaag cccctccctc ataactgaaa agcggccccg ccccggcccg aagggccgga
     1381 acagagtcgc ttttaattat gaatgttgta actatactcc gtcatcgctg tcagtgttct
     1441 ggctggaagt cctcagtaca cgctcgtaag cggccctgac ggcccgctaa cgcggagata
     1501 cgccccgact tcgggtaaac cctcgtcggg accactccga ccgcgcacag aagctctctc
     1561 atggctgaaa acaggtatgg tctggcaggg caagggatgg gtaaggtgaa atctatcaat
     1621 cagtaccggc tgacgccggg cttcggcggt tttactccgg tatcacatgt aaccacagcg
     1681 tgccgccttc catgccgctg gcgcggcata agcatatgtt ggtggctgtg tctgaaaggt
     1741 tatatactct gcataaaacc tgacaacacg cagattgcca ggcaaatgag cattatgcat
     1801 ccggttatcg cctgcctgtg aaacaatatc accggggcga atatcgatac tctgactcgt
     1861 tatacccatg cgtgtggcat caaaaaacct gcaattgccc tttattgaat gaaaggggga
     1921 gtcaattatg aatagcacca cacattacga aaacgccaat ttcctgcgcg agctggccga
     1981 aagcctgcct cgtatttttc cagaaggcag tacagacaag tctgcactat tgcaacgcct
     2041 cgctaatgaa gaactggcac gggcggaata cgacgaacag atccgagcga aagttgccgc
     2101 tgcccgcgcc gataagcggc cgggaatgag ttccgcgcaa ctgcgccagc aactacaggg
     2161 acgttatcag gaactgcgca atgagttatg aaatagaatg gcgaccaggt gcgattgagg
     2221 atataacggc gttgtttgaa tatctggtcg agaatgcatc tctttgggat gcaaggaacg
     2281 tgacagagcg tctgatcact gcaaccgatc gcctggctga ttaccccagg ctgtatgaaa
     2341 cggatgaacg ctatggtgaa ggggttcgcc gtattagctt acttggacag catgtacttt
     2401 atgaagtgaa tgatgaggcc agtcgtgtca atatcctggc ggttgtaggc cagcgtcaga
     2461 atccccgatt cattctttga gtgtccggct tggaactcca tcttcagaga atcgatcaac
     2521 gttctttagc tccttccact aacagccgac ctatctcaaa caccgcagct gaccgtcccg
     2581 acttcaccgc ttcggctttc tgtccctcaa caaaccagtt attaccgtcc gttcggacca
     2641 actcaaacat ccatgacata tcgtaaacgt gttccgggat cagcgaccct tctccggcca
     2701 gaatacccgc cgttatggag tggttgcccc cgtgcacaaa gccaatacgc cagggcaacc
     2761 acaggtcaac atagtggttg tttttatctt gcttccacgg cttcccctta tgggttccaa
     2821 tgcgtgaaac gttatcgata tagcgtggta ggctccaagg ccacggcagc actatgtcgc
     2881 ttgccagcga caacggataa tcagcgccgt tcatctcaca ctctttcatc ttttcgtaag
     2941 attgtatttg ggtaagtccc ttaaagaaga actcctgcgg ggtcatatcc gggcgggcat
     3001 ctgttccctc ctcagctacc gccagcaaga aatcactctg tactggccgc acgatagcgc
     3061 gaatgagatc tggtagcgcc ttaacgggta gtttctctgc cacagaaagc agatgattga
     3121 agcgtttttt ttcattggct atagttgctt tatctttctt gtttcggttc cagaacatca
     3181 ctgtctgtag ccctccttat cgtgatcagg atgatggttt tcattctaat ggtgtagtag
     3241 tttcacgtca cgcgcacgtg catattcttc gaaagcttcg gcgttagccg gtcaaccagg
     3301 ggtttgaggc ccaaccgtac gagatcgtac gctaagttca ttttttgagc agaagaggtg
     3361 agtaaagaaa acgagggttt tatttactct tcccgtcaat gccagtagcc atgcggtttc
     3421 agggactttc agtgttaata aactcggtaa tcaaatcaac gtaaacctgc ctaacaacgc
     3481 cacgacttta ttgacttaaa atcatatagt tagcttctta gcgtacgttt ccgctccatt
     3541 gggcttcaaa ccccacaccc aatgacatga gaaaagctgg atctgattct caaaatgctg
     3601 ggatacccat cgagatggag aactcagtca atgttccatt ctttctgaaa tatgtgtggg
     3661 gacactgatc tgtcgggagc cggatgcggt agttccgcag gtccggttct gaggaggggc
     3721 ccgtccgggc aaccggcggg tctactcacc tcatccccct acaaccactc ccattcgttt
     3781 aagtattttt aaacctgctt cctgtggtat ctttatagat aagatcctgt ttatctcagg
     3841 atttatatcg agaccttctg tcattgaaaa atcacagtga gacaaatcag aatgtctgaa
     3901 ctctgtatta ttaaactccg aaccagtaaa atcagattta cgaaggtctg tttcctcaaa
     3961 taaacaatca cggaagcgac aggataaaaa aatagatttc tgtaaccgta aactaataaa
     4021 atcaacaaat ctcaaatcac aatttacaag agaaaaagta cagggaaaca taatgtctgc
     4081 tgcatttact ccttgtaata aacaatcttt gaattcacag tcaataagtt taaaaaaatt
     4141 aagttttaaa ttctttattg agcagtttac gaagcgacat ttttcgaact cacaatcgcg
     4201 aaagttaaag ttgtcaagct gtattcgttc aaatatacaa ttgtaataat ttacacctga
     4261 taattcactt tcactgaggt gtcgttttgt gattcttttt tctattatat ccatgtgtca
     4321 gtctcctgtt cccataactt ctttaataaa tgccttttct ggagttgttt cattattgga
     4381 ttgaataaaa tcactcatat cagaataacg atttatacta ttttttgaaa gcatatagaa
     4441 ggggatttta tctcttgtta attcatcaaa aatatgagtt gagaaaaata ccgttttccc
     4501 gtcagcggtg atcttattta tcagttccca taacatcatt ctgtactgaa tatcaatgcc
     4561 tacagttggt tcatccagta aaaataaacg ggcatttttg caaagcgtta gcatcaaaga
     4621 tatgataagc caacgcttct ctccataact taccgtgtaa gtccttttac gtcttatttt
     4681 atcatagcga atgaaaaaat tatcattcca tttatgatta agctctgtcc atgcctgttt
     4741 tttagttaac ttattgaagc agcaaatcaa atcaagaacc tcctcattcc ttagtgtacc
     4801 tgaaagattt atgacttgag gtagacttac taattctcca ccagagaaat ttcgcttgag
     4861 ggtcccttca taattactga ctccgcccct gataaggtta aaaagagtgg tcttcccggc
     4921 tccattttct ccaagcagac ctatcaactc tccctgctca atcttaagcg acagattatt
     4981 gaaaacaggg ggtaaattta ctttatatga aaagctcaga gagttgattt ctaaaagagg
     5041 tatggtcatt gagaactcca gactggctca gttttgaagg ttagtgctga aataatactt
     5101 atgattaaca ttatactata gaaaaatatc gtcatcagag acaactcctg gtctgactgg
     5161 agtattgtag aatagatggc gataggatta acctgattta tccagtaaac gatcccctca
     5221 ttatatttta atgatacaat tcctgatacc atacagacag ttattaatac agaatagata
     5281 gtgctggctg tttggaatgt gactctgaac gatgccatga aagtgagtga aaccatcata
     5341 aatgcattta tgtatatcga ttttaaaata atcattacta tttgataatc tggacttgcc
     5401 tggaatcctg ttagtacgac taaaatgaaa aaaaacacat acaaaataga catgataagt
     5461 gaggctatta attgagaacg aataaataat agtcgaccat ccatattatg cacgaaggta
     5521 gcaataaaac cactttctct tcttccgacc agatacagac agtaattaaa cagaacaaca
     5581 gaaaaagaaa tgtagcctac aaaccatgat atttgttttc cgagccatgc tgtatcacca
     5641 taatgaagtt caatttcatt gaaatgaagg aaaaagaaca acactgtagg tgacataatt
     5701 gtccatatta agctgaaagg ggttctgatt tgttccatca gaaaaattat cgccattttt
     5761 aatgtaacca tttgttatcc ttatgggaat ggtaccatct ttgattctct gactttaata
     5821 ccgtccccgg tatggtaaat tttattatta atgtttattg cacctgagtt attcatatga
     5881 aggaaaaaat cagggcttac tatttttgtg taccagacaa ggctgttact tactctttcc
     5941 ctggcatagt aaacaaaaat attatcagaa atttgttgaa gatagtttaa taaatttgtg
     6001 tctgacgtaa tattttcctc aagcgttaac ttgacatcat cagacagtag taccgtattt
     6061 tcacacaaat ccgtaaacga ctcgtacttg ttgcatgaca taaagtgacg ctggtaacta
     6121 tcaataatgt catcatcagt ataaccgcca ataagaaagt tgtgcaggca tatatacgat
     6181 tgccacaatt ccactacgga tttacaaagt gcttttttca gactattagc ataggataat
     6241 ccggtactgt attttattcg actgattttg ttttttgtgc catacagggt tagtactgcg
     6301 tgtccaggaa ctccgggcag ggtgatatcg aaaatcctga tatctccttc tgacctgaga
     6361 gccagtaaaa tctcatctat atgatttatg cctgttacta tttcactgga tatttcagta
     6421 ttggcttttc cctgtaacca gtaaagaagg agggactgtc tctccataaa ttcacacaag
     6481 gaaccttcta tggcatcgtt caaactacca tgaaagctac atccgcatgt atctctgtca
     6541 ggataaaatt tcagatcatc tgcagcggtt atattgtcga gtgcaattat gactgcaggt
     6601 atttcttgtt gttcaaggct aaacagatta aaggctctga ccgttttaaa tttatgggtt
     6661 atgatttcat cgcgggtcag tgatgagatc tgaaaaaatg cttcggtaaa agcctttgca
     6721 gcagatggag gcatcatctc atataatgtt ttctgaccac cggtgactat ctcattaaaa
     6781 aaatgacggc gttcaaaata ttcacctatt gccccctgaa ttgacttcag agtttcaccg
     6841 gccgcgctgg ctggtgtaat acgctcatag tcccatatct gagaaaacgt tggcatattt
     6901 ctgttcagtt ttggactcat ggccattgtg gccggccatg cggacataag gttactgtag
     6961 acatttatca tcgtttacat ctccaaaaaa ctgaacgatc agtggcgcta cagtcctctg
     7021 atccagattc attgtttttg ctacgtatga atcggtatat cccgcccata cccggttttt
     7081 cagtcctatt tgatctgcaa ccaatactgc gttctgatac atcgaacctg tttccattaa
     7141 ggccatccgg tatcctctgt agcgatattt gaacaaagct ttttcaaaaa taatgcaata
     7201 gacgagagca aaatggggtt taccaagacg ttccgaatcc ccaccggaca ggcttcggta
     7261 gagtgactga gtattacatg tagcaacagg ttccagtgcc tgacttagcg gcaggtagtg
     7321 ataaacatta gttcctgcct gccagttttc tgtattttca gataatctgc ataaaaaaac
     7381 ttcaatcggg tacaatgccc ccccagaagg ataaggtctt cttacagagc caggatcagg
     7441 tgagctgaat gcattgacta ataacttttc aatagtacga atggaaagtt tatttttgtc
     7501 gcaaaagttt attcctgatg ggagcctttc acgactaaaa ttatgtgatg aggatatgtt
     7561 tattacggag ctgaaacctg gcctgaagag aacttcttta ttttcaaatt tctccagatg
     7621 ggcaagaggt accgcggaca cgaaagttcg ttcagcaaat tcggggaggg aagcaaagtt
     7681 acctctgaca tgaaaatctt taacaatggc cagaacttca ggatctgtgt aatgcgttac
     7741 ttccactaaa gagagttcgt gttttgacat gttatctctc cagacagctg caagcctgcc
     7801 agtgaattac cggctcttta cataaaatac aggtgattaa atcagcgcta acagatgaca
     7861 taaagttatc gacatgactt ttaaccagtg aagtacctgt caactcctga agtcgccgtt
     7921 ttattaaatg atagctgaat cctctttctg attcgcctaa agccaatgct ggtagtgtca
     7981 tttggtattt tttcagtaac tgaagtaagt ttgcccagga catttcgtta cgtctgaagc
     8041 ttttttcttc cctgctcagc catctctcta tatgacaaaa atggcaggga gtaccaagat
     8101 caggtgaata tactccatct atcctgaatg actcctttag gtagtagctt tggatgaagg
     8161 caacaccagg gttactttca aattttgaat agattctttt tacaatgtct gaatgatagt
     8221 tttcgagatg taaccagatt agtgttgaat cgctcacatt aatattatta tcttttatat
     8281 caatgatatg agaaacaaaa acaccatcag atttccattg ttcccgggca ttactgaaaa
     8341 gatgtggaac atcgcttatt atgactgagt ttacccagag aggtgatgtt ttcgttttat
     8401 ttatcacgcc tgtggtaata agaaactctt tgcccttgtc tttatcaata agcgattcgt
     8461 ccagtagttt atcaaggagg tatttagaaa taataccctg tttggatcgt aggctttcga
     8521 gtactttttt cattccctca tgtgtaatgt ctactgaaga aatgtaggta ataagcaggg
     8581 tctttgtatt tctggaaatt atctcaaacg gcagaatatt gatcatatct tttccttttt
     8641 taatatcagg gagcaccatg ctccctgaac ggttaattca acgtatcaga tatgtgaacc
     8701 acttccgccg ctgccaccgt ttccaccact acaaccgttg ctgcaaccac cacaaccgcc
     8761 accttgacca ccgcagctac cgccgccgcc gccgccgcca ccaccaccaa tgccaacacc
     8821 taatggagac tggcgtgata atttaagagc atcaacggac aaaactacac caaattcact
     8881 cgcttttaat tccataagga ctcctttttt aagggaaatt aatgcttatg acatctgaat
     8941 agtatgttgg ccaacactag ttacttgccg taattaacta tattttgcaa tgataatttg
     9001 aactaaattt gtacgcctgt taaatattta ataataatat cagttggtta tgtttgtgct
     9061 gttattgttt ttttacaaaa attaatattg tgtttacatt ttgctttcag ttgctgtcag
     9121 gatgtcacac taccccttta agcccccact ggtctggcag ggccgggggt gggtaaggtg
     9181 aaacctgtca atcagtaccg gcttacgccg gtatcatatg caacaactga gtgccgcctt
     9241 ccatatcata tcatttgccc gtttcccgcc gtgcagatcc ggtttccggc tgaagtggat
     9301 ccagacctga tttgttgctg agtatcggta aaagagcggc ttataatcta ttctgaaaca
     9361 tggcaagtga atctgggctg tataattccg gcaagtgtca tctgtattta aaggtcgtgt
     9421 gagtatgaaa tttatggaat gtgctgtccg ggatgtgatt tatgggacca atgtccgtat
     9481 tgtcaaaccg gtcaacattt atgaatgtga actcagggac aatgtgtttg tcggcccctt
     9541 cgttgagata cagaaaggct gtgtcattgg tagtggaagc cggatacagt cgcacacgtt
     9601 tatttgtgag aacgtaacac tgggggagaa ctgcttcatt ggtcataacg tgacgttcgc
     9661 caacgatctg tttcgttcag gagcaccaga tccgtcaccg gataactgga tcagcattac
     9721 cctgggggat tcggttactg ttggcagtgg agccattatt ctgtctccgt atatatgcag
     9781 cggagctgtt attggtgcgg gggcagttgt agtaaaaccg attgagaaca aaggcattta
     9841 tgcaggaaac ccggcaagac tgatcagaat attatgaaaa agaaaagggc cgttactggc
     9901 cctttttatc agaggtaggt ctgtgaatac ggcaggtgta cagaaatcga ctgccgggga
     9961 tcgatttcca gggccgcccg gtattctgcg tcagtgatat cacctttttt cagtaaataa
    10021 ccgagagcat cgtttcccag ccctgacagt atgcgtattc tggcgatccg gactggcaaa
    10081 taacccatca aaaacgttat tgccagacat tgcgaactca ccaattttga ttattggagc
    10141 cactttttca taagttccgt gaaattattt cataataacg accctgttta ttttatgtaa
    10201 tgactggcaa taaaataact tgattaagtt ccctttatcc agcctgatag tggataaagg
    10261 aaactcaatc ataatttaat tagtttatta acttcatcgc attctttttt gtctcctcat
    10321 cacttttttg ctccgattgt gaagaggact gaatgattgt tgaagaattt aaatcggcca
    10381 tctcttttgg aaatagcgat ctcaatatat tcacgatatc tgaaaatgtg gtttctttcg
    10441 tcagcagttc acataaaagg aaaggggccc tgggatcttg tctgtataag gccagacctg
    10501 ccgtcagtgc agcccggtta aggcggctgc gttccccttg cgggatactg tccagtgtat
    10561 cacaaacaat tttatctgtt tgatttacat ctggatttag cttaaaggca atggttctgc
    10621 gcttgtccat cattaattac ctatgagata cataccgtta actaaatcat attgagagtt
    10681 attggtttta aaaaaacgtt catcacgaat ctgtgtgtgt ttttttactg catcgcatat
    10741 taattctgcg ccaccaccta taaccataac atgagtataa ccagaaaatt cattgagtgt
    10801 atttaataca cgttgctcaa gtttacgaag tgcttcattc attgcttcgg tgactattga
    10861 tattttgttc tcatcattaa ttcgttgctt cagatagtta ttatcttttc tgtgaataat
    10921 tatatcatca gcaagatagc tacttccttt tgttctcgca agagaaaggg catcttttac
    10981 tgcagatgtg accagagata caccaagaga tgagtctccg tatattttac tgatccccga
    11041 taatttcccc attacctgag aaatatctaa tgtggtgccc ccgagatcta taattaataa
    11101 agaatctaac tcatccagtt cttgtagaac ttcataacct gccggtatag attcaggcat
    11161 gacttttaca tcttttattg tgaatgtatc cccaccattt aatgtaattt ttttccggaa
    11221 gtttgctttc ttacgctcaa tattttccgt attgggttgg ttattcctgt cgtaatactc
    11281 tgtcagagga agtgtgcaaa caatatccac ttcgcttacc ggcagaccac tggtcagtaa
    11341 ggcgtggtgc accgcaacga cattaacgtc gctgtattgc catgcgatat tggttgtgac
    11401 tacagcatcc gggctgattg gatcaaatga atactgttcg ccgttcagtg tgtagttaaa
    11461 gaccttttta tcaccaaaag aaactgccca ctcgcgtttg aagctgttcg ggctaatgtg
    11521 ctgtttaatt gttccgtcgc tttcctgcca ctgtagtttg atgtttgttg aaccgtcatc
    11581 aatgaatacc aacatttata aaactcctta tggtgttttt tttggtgttt gtttgggtgt
    11641 gttttgggct ttaaatgggt ttatttgtca agtttacccc attttaacta tcaatcaatg
    11701 attatttgtc ttgttttggt gttttgttgg gcttggtatg ggttgttttt gggttttgtt
    11761 tggcggataa caaaagatgt cgccgggctc ctctttttac tgcgccggct gacgcggcgc
    11821 ggcaggaacg ctgcctgtgg tcagtgtccc gcgtccggcc gggcacggga cgggcgcttt
    11881 taccgctccc ggctggcgtc ggtgacagtg tacgccagcc cgtcgccctt ttctgatgag
    11941 cgcccttcaa gccgctttcg cggcatagcc ttgccgtcaa aaagacgacg gctgcggtat
    12001 tccacggtcg gcctgacccg ttaccgggcg cggtgaacag cccacaggca gcggggaacg
    12061 ggcgccacag gggcgccctc ccgatgctcc tgtgaggata attcccatgc caaactggtg
    12121 ctcgaatcgt atgtattttt ctggtgaacc ggcacagatt gctgagatta aacgactggc
    12181 cagcggtgca gtcacaccgc tttatcgccg cgccacaaat gaaggtattc agctgtttct
    12241 ggccggaagt gccggacttc tgcagaccac tgaagatgtg cggtttgaac catgtcccgg
    12301 actgacggct gccggacgtg gcgttgtatc gacggaaaat atcgcgttca cccgctggct
    12361 gacacacctg cagaacggtg tactgctgga tgagcaaaac tgcctgatgc tgcatgaact
    12421 ctggctgcag agcggtactg gacagcgtcg ctgggaagga ttaccggacg atgtcaggga
    12481 taccatcacc gcacttttca ccgcaaaaag aggtgactgg tgtggcttct ggagtaacga
    12541 ggatgtatcg gtgtggtgga accgtctgtg tgacaacgta ctgccggaaa aaaccatgcc
    12601 gtttgacctg ctgacggttc tgccgacccg cctggatgtt gaagtgaatg gctttaacgg
    12661 tggtgttctg aacggtgttc cttctgcata tcactggtat acggaacggt atggcgtgaa
    12721 gtggcctgtg gggtatgagg tgaatatcag tagtcaggga gacaacttca ttcaggttga
    12781 tttcgacact ccgtggtgtc agccggaaag cgacgttgtt gcagaattaa gccgccgttt
    12841 cggctgcacg ctggagcact ggtacgccga acagggctgc aatttctgtg gctggcagtt
    12901 gtatgagcgc ggagagcttg ttgatgtgct gtggggggaa ctggaatgct cttccccgac
    12961 agatgacgat gagctgccgg aagtcaccgg acctgcgtgg atagtcgaca atgtgacgca
    13021 ttatggcgga tgaagtatga cggagacggg cgggcaaccg cccgtttctt ttccgacaaa
    13081 ggatgtcgcc gtgctcctct ttttactgcg ccggctgacg cggcgcggca taaacgctgc
    13141 ctgtggtcag tgtcccgcgt ccggcgggca cggggcgggc gcttttaccg ctcccggctg
    13201 gcgtcggtga cagtgtacgc cagcccgtcg cccttttctg atgaacgccc ttcaagccgc
    13261 tttcgcggca taaccttgcc gtcaaaaaga cgacggctgc ggtattccac ggtcggcctg
    13321 acccgttacc ggacgcggtg aacagcccac aggcagcggg gaacgggcac cacaggggtg
    13381 ccctcccggt gtcctctgta agagaaggag tgctgttatg tcccgtttta tcctgggtga
    13441 ctgcgtgcgt gttatggcca cgtttccggg caatgctgtc gatttcatcc tcaccgaccc
    13501 gccgtatctc gtcggtttcc gtgaccgttc cgggcgcacc atcgccggcg ataaaaccga
    13561 tgaatggctg caaccggcct gtaatgaaat gtaccgcgtg ctgaaaaaag atgcgctgat
    13621 ggtcagcttc tacggctgga accgcgtcga tcgctttatg gccgcctgga aaaatgcggg
    13681 attcagcgtg gttggccacc tggtgtttac caaaacctac acatcgaagg ccgcatatgt
    13741 gggctatcgc cacgaatgcg cctacatcct ggcaaaagga cgtccggcgc tgcctcagaa
    13801 gccattgccc gacgtgctgg gctggaaata ttcaggcaat cgtcatcacc cgactgaaaa
    13861 gcccgttacc agcctgcaac cgctcattga gagcttcaca cacccgaacg cgattgtgct
    13921 ggacccgttt gcaggcagcg gctcaacctg tgtggccgcc ctccagtccg gacgccggta
    13981 tatcggtgtc gagctgcttg aacagtatca ccgtgccgga cagcaacgac tggccgccgt
    14041 gcaacgggcc atgcagcagg gggccgcgaa tgataactgg tttgaaccgg aggctgcgta
    14101 aatgaactat gccggacacg aaaaacttcg cgccgacgtg gcggaggtgg ccaacaccat
    14161 gtgtgacctt cgggccaggc tgaacgatat ggagcatcgc tgtcgctttg attccgatgt
    14221 gcttgttgaa cgcctgacac gccagacgct gtatcgcgcc aatcgcctgt tcatggaggc
    14281 gtataccgaa attctggaac tggattcctg cttcaaagat tgagaaggag acgagaatgt
    14341 acggaacatg cgaaacgcta tgccgggagc tggcagcaaa gtatccggga gacacgccgc
    14401 tgatgctggt tatctggtcc ccggaagaaa ttcaggccct cgctgacgga atggatattt
    14461 ccctgtccga tcatgaaatc aggactgtcc tggcgcgcct ggaggacatc ccggaagacc
    14521 agcggactga atccggtatt tcttccggtg cggcgatgga gatcatcaat aacgtgagag
    14581 aaaaccgcca ggtgaccgtc cctgctgaac tgctggcgtc cctgattcag accgctgaac
    14641 aggcattgtg gaaacgtgaa tgggccgccc gggatcatgg cctcgccgtc ccggaatgcg
    14701 tcacccgccg tcaggcggtg gttaatcagg tccgcatcct gctgaaaaac aacacacacg
    14761 aaaacgactg atgttatcgc cgcctccggg cggcgataca gggagttcat gaattatgaa
    14821 tgaaacgctg aatgcactga tttatcgcca cgccagcaac ctgttgctgg cgcagggctg
    14881 gccggaagag acggatgttg accagcgtaa cccgaagtat ccgggctgga tcagcattta
    14941 cgtgcggctg gatgcgcccc ggctggcgac gttacttatc aaccgtcacg gcggcgtact
    15001 gccgccgctc ctggcctctg ccattcagaa actgaccgga accggagcgg aacttgttct
    15061 gtccggcagt cagtggcagt cgctgccggt acttccggca gacggaacgc aggtgtcttt
    15121 cccgtatgcc ggtgagtggc tggcagagga cgaaatcagg gccgttcttg gtgcggtacg
    15181 cgatgcagta tgcagtgtca gttaccaggt ggcagaagat gcgcggcgta tccgtgcggc
    15241 gctgaccacc accggtcaga cgttgctgac ccgccagacg cgccgctttc gcctggtggt
    15301 gaaggaaagc gatcacccct gctggctcga tgaagacgac gaaaacctgc ccgtggtgct
    15361 cgatgccatc ctgaaccggg gcgctcgttt ttcgtcggtg gaaatgtatc tggtcagtga
    15421 gtgtgtggag catatcctgt ccagtgggct ggcctgcgat atgctgcgta taccggatga
    15481 accgccccgc cgctggtttg accgtggtgt tctgcgggag gtggtccggg aagcccggaa
    15541 cgaaatccgc agcatggcgg attcactggc gaaaatccgg aaatgatgac gctggcgggg
    15601 aaaaatctcc gccttttcca gccggtcccc ggaaagagca aaaggatgtc gccgcaggct
    15661 ccgctttacc cggccatgcg gggcatggcc ttgtgggttt tcagttatgt ggcctcagcg
    15721 tcgtgtgcgg gctgtgccgt gcctccatct ttgccgggcc tgcagggttg caaggtaagg
    15781 tgaaccgctg cggtcacccg gtccctcctt cccgtctgcc gtgattttcc ggtcgttcac
    15841 ccgctcagat ttcgcggtct caccctccaa ctcccgtcag ccgtgcgcgt caggctgcgg
    15901 cttcccttgc gcccttgcaa ccctgcaggc ccggcaaaga tggaggcacg gcaccgcccg
    15961 gtgtcgcgga atatgtgaac aacggaggaa aacatcatgc aatatgcgaa acctgtcact
    16021 ctgaatgttg aagagtgcga ccgtctctcc tttctgcctt acctgtttgg cctggatttt
    16081 ctgtatgccg aagcgtctgt atacgcgctg gcgaaaaaaa tgatgccgga atatgaaggc
    16141 ggattctggc acttcatccg cctgccggac ggtggcggtt acatgatgcc ggatggcgac
    16201 cgtttccaca tggtgaacgg tgcaaactgg tttgaccgta cggtcagcgc cgatgccgca
    16261 ggcatcattc tgacttccct tgtgattaac cgccagttgt ggctgtacca cgacagcggg
    16321 gatgcaggac tgacccatct ttaccggatg cgcgatgcgc agttgtggcg tcacatcgaa
    16381 tttcatcccg aatgcaacgc gatttacgcg gcactggact gattaacgga cggggcggca
    16441 atgccgcccc tgtaaaggag acgagaacgt gtactgtact gttaaagaaa tcatccgcga
    16501 tgtactggat acagacgtgc cggacagtga atgcgttttt gccgtggtgc tgacccgtgg
    16561 ggatgtgcgc tacatagccc aggactggaa cctgtcagac gatgagctgg aaaccgtcat
    16621 gcagcggctg gacgatgcct ttgaatatgg tgcggatgtc agcattgttc acgacgttgt
    16681 tcgtgagctg atggaagaaa agcgagccag ccgtcaggtg acagttccgg cggtgatgct
    16741 ggaaaaagtg atggcgctgg caggcagtga aatgaagcgc ctgtatgccg tcgggagtga
    16801 gaacgggggc gacggtgacg cattcgtcag ggaagaacgc gaagcaatgg acgttgtgtt
    16861 acaggcgctg gacggggagc acatgtcatg aatatcagca cagaaacccg cgaaattctg
    16921 cgtaattaca gggccgtgat taatgcgcgg cgtcgtgaaa tggggcagaa accgctcacc
    16981 accgcgcaga ttgttgatga aatctgcgat tttgtggcga atcagcaggc ggttttcctg
    17041 ggcggtcact acatcttaca gggcagcaga aacaggtgat acaggggcag gcggtggagg
    17101 ccgcctgtca gcccgcgcga acccccctgg caggctggcg cctgccggaa gggaagcggg
    17161 ccacgctggc gcgtcgcccg ttacccttcc cgtctgtgat gtgtctgact caggagtgtt
    17221 tctttcttat gttatggaac tgttcctgat gttgttgttg ttgttgttgt tgttccttta
    17281 tctgctgctc tgattctgac tactgcagtg ttgttctgtc tgccggacgc accttcggct
    17341 cccggctgcc tggcggcatc cggtcgtcag gcccgactcc gacaggcagc tgctggcgca
    17401 cccgccagtc tccgccgaac ccgctggcgc ggtttcgggc tgtcgctacg gtccgatgcg
    17461 tgaaaacccc cggcttgcag cgaccgttcc ggtcgcgccg cctctgtcgc gccgtggcct
    17521 gcgctcccgg catcccggca aaaggccgcc ggaatgtaag gcgcaacgcc gtttcgcaaa
    17581 ccgcgcttca cgtcgttgct gcgggtccct gctcattgcc tgccgggtgc cacacacccg
    17641 tatgagtccc tgtcgccggg ggcatagaca gccacaacct gccgcactga ctgtccaggg
    17701 taaatgaaca gcccacaaaa ttttttaccc aaaaaccggt aaaaaatttt gcgttctgcc
    17761 caggacaggt
//
